Document K69ZLe8LO5vwRyRmBdwaj5re6

BACK TO MAIN SOLUBILITY IN OCTANOL- SHAKE FLASK METHOD TEST SUBSTANCE______________________ Identity: Perfluorooctanesulfonate; may also be referred to as PFOS or FC-95. (1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8heptadecafluoro-, potassium salt, CAS # 2795-39-3) Remarks: The test substance is a white powder. Sample was recrystalized from a production lot of FC-95, and assigned a test, control, and reference number TCR 00017-046. Purity determined to be 97.9% by LC/MS, 1H-HMR, 19F-NMR and elemental analyses techniques. METHOD___________________________________________________ Method: Based on OECD 105, OPPTS 830.7840. GLP (Y/N): Yes Year completed: 2001 Octanol Source: Aldrich Screen Test: Lot JU0873804, 99+% Definitive Test: Lot 06238CI, 99.9+% HPLC Grade Remarks: The definitive test consisted of placing ~0.010 g test substance with ~10 mL octanol in centrifuge tubes. The tubes were shaken at ~150 rpm at ~30C for 24, 48 or 72-hours followed by 24-hours of equilibration at 22 - 23C. Following equilibration, samples were centrifuged and the supernatant was analyzed by high performance liquid chromatography with mass spectrometric detection (LCMS). RESULTS 24-hours: 56.9 mg/L 48-hours: 55.7 mg/L 72-hours: 55.4 mg/L Mean solubility of PFOS in octanol = 56.0 mg/L The 24, 48, and 72-hour solubility concentrations were averaged to obtain the overall mean solubility concentration CONCLUSIONS______________________________________________ The overall mean solubility concentration of the test substance in pure octanol was 56.0 mg/L. BACK TO MAIN Typically, the Column Elution Method is recommended for use with substances with solubility screening results of < 10 mg/L. However, the shake flask method was utilized in this study because of the difficulty in obtaining tubing compatible with octanol and the possible explosion hazard posed by possible leaks of a flammable solvent in an incubator. Submitter: 3M Company, Environmental Laboratory, P.O. Box 33331, St. Paul, Minnesota, 55133 DATA QUALITY____________________________________________ Reliability: Klimisch ranking 1. REFERENCES_____________ Studies conducted at the 3M Company, St Paul, MN, 2001, Environmental Laboratory Project Number EOO-1716. OTHER Last changed: 6/22/01