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AR226-3186 TRADE SECRET Study Title H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Volume 3 of 5 Laboratory Project ID: DuPont-4739 DuPont-4739 TEST GUIDELINES: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (1998) AUTHOR: Don A. Delker, Ph.D. STUDY COMPLETED ON: October 23, 2001 PERFORMING LABORATORY: E.I. du Pont de Nemours and Company Haskell Laboratory for Health and Environmental Sciences Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 jHf^ WORK REQUEST NUMBER:! y ^ ij^B SERVICE CODE NUMBER: i SPONSOR STUDY NUMBER: )fl----B i H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX F INDIVIDUAL FORELIMB AND fflNDLIMB GRIP STRENGTH ASSESSMENTS 608 Company Sanitized. Does s H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL PORELIMB AND fflNDLIMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS BASELINE FORELIMBGR[PSTRENiGTHCke) HINDIJMBGRD'STREW3TH (kg) ANIMAL MEAN OF NUMBER 'TRIAL 1 TRIAL2 TRIAL 3 TRIALS MEAN OF TRIAL 1 TRIAL2 TRIAL 3 TRIALS GROUP 1:0 mg/kg/daiy 641083 641084 641085 641101 641105 641123 641154 641159 641165 641215 0.71 0.55 0.86 0.94 0.62 0.86 0.46 0.70 0.46 0.66 0.75 0.68 0.93 0.75 0.84 0.84 0.68 0.85 0.54 0.63 GROUP ffl: 50 mg/kg/day 0.75 0.74 0.77 1.01 0.61 0.86 0.74 0.86 0.40 0.37 0.73667 0.65667 0.85333 0.90000 0.69000 0.85333 0.62667 0.80333 0.46667 0.55333 0.20 0.22 0.52 0.44 0.29 0.31 0.30 0.20 0.24 0.37 0.23 0.27 0.22 0.45 0.30 0.28 0.31 0.19 0.25 0.41 0.41 0.44 0.45 0.44 0.32 0.34 0.37 0.17 0.34 0.33 0.28000 0.31000 0.39667 0.44333 0.30333 0.31000 0.32667 0.18667 0.27667 0.37000 641055 641056 641073 641081 641144 641146 641178 641198 641218 641224 0.45 0.51 0.66 0.82 0.56 0.52 0.64 0.63 0.61 0.61 0.89 0.72 0.79 0.84 0.57 0.91 0.71 0.77 0.76 0.57 GROUP V: 250 mg/kg/dav 641061 641089 641102 641134 641137 641162 641190 641197 641200 641202 0.76 0.59 0.93 0.66 0.61 0.56 0.50 0.39 0.66 0.81 0.95 0.63 0.88 0.53 0.75 0.80 0.65 0.87 0.80 0.80 0.55 0.47 0.62 0.60 0.67 0.58 0.40 0.56 0.78 0.79 0.94 0.70 0.85 0.69 0.56 0.93 0.63 0.85 0.73 0.74 0.63000 0.56667 0.69000 0.75333 0.60000 0.67000 0.58333 0.65333 0.71667 0.65667 0.88333 0.64000 0.88667 0.62667 0.64000 0.76333 0.59333 0.70333 0.73000 0.78333 0.30 0.29 0.34 0.22 0.19 0.41 0.27 0.28 0.26 0.33 0.35 0.24 0.24 0.20 0.13 0.27 0.20 0.25 0.24 0.41 0.46 0.30 0.26 0.36 0.17 0.17 0.27 0.37 0.36 0.31 0.37000 0.27667 0.28000 0.26000 0.16333 0.28333 0.24667 0.30000 0.28667 0.35000 0.33 0.42 0.31 0.24 0.34 0.36 0.31 0.45 0.31 0.52 0.40 0.27 0.31 0.26 0.27 0.45 0.34 0.25 0.44 0.40 0.37 0.29 0.30 0.48 0.22 0.43 0.30 0.38 0.53 0.37 0.36667 0.32667 0.30667 0.32667 0.27667 0.41333 0.31667 0.36000 0.42667 0.43000 609 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL FORELIMB AND HINDUMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS BASELINE FORELIMB GRIP STRENGTH (kg) fflNDLIMB GRIP STRENGTH (kg) ANIMAL MEAN OF NUMBER TRIAL 1 TRIAL 2 TRIAL 3 TRIALS MEAN OF TRIAL 1 TRIAL 2 TRIAL 3 TRIALS GROUP Vn: 1000 me/kg/day 641064 641092 641143 641153 641167 641185 641189 641203 641213 641216 0.78 0.89 0.71 0.37 0.71 0.92 0.59 0.36 0.89 0.52 0.63 0.53 0.74 0.55 0.79 0.87 0.32 0.76 0.79 0.74 0.59 0.77 0.61 0.58 0.75 0.80 0.65 0.51 0.58 0.66 0.66667 0.73000 0.68667 0.50000 0.75000 0.86333 0.52000 0.54333 0.75333 0.64000 0.22 0.39 0.27 0.16 0.33 0.27 0.30 0.31 0.35 0.36 0.22 0.25 0.17 0.32 0.33 0.45 0.31 0.35 0.38 0.35 0.20 0.38 0.19 0.32 0.42 0.37 0.33 0.40 0.43 0.46 0.21333 0.34000 0.21000 0.26667 0.36000 0.36333 0.31333 0.35333 0.38667 0.39000 610 Company SanStized. Does not eonSain TSCA CB1 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL PORELIMB AND HENDLIMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS WEEK 12 FORELIMB GRIP STRENGTH (kg) HINDLIMB GRIP STRENGTH (kg) ANIMAL MEAN OF NUMBER TRIAL 1 TRIAL2 TRIALS TRIALS MEAN OF TRIAL 1 TRIAL2 TRIAL3 TRIALS GROUP I: C1mg/kg/daiy 641083 641084 641085 641101 641105 641123 641154 641159 641165 641215 1.28 1.02 1.29 1.66 1.54 1.66 2.01 1.27 1.29 1.19 1.09 1.57 1.06 2.07 1.22 1.87 1.53 1.10 1.22 1.00 GROUP III 50 mg/kg/day 1.11 0.96 1.20 2.37 1.49 1.71 1.95 1.24 1.53 1.08 1.16000 1.18333 1.18333 2.03333 1.41667 1.74667 1.83000 1.20333 1.34667 1.09000 0.29 0.50 0.85 0.66 0.76 0.56 0.57 0.55 0.27 0.69 0.37 0.47 0.69 0.40 0.77 0.62 0.80 0.44 0.37 0.62 0.56 0.66 0.75 0.36 0.77 0.67 0.64 0.30 0.57 0.70 0.40667 0.54333 0.76333 0.47333 0.76667 0.61667 0.67000 0.43000 0.40333 0.67000 641055 641056 641073 641081 641144 641146 641178 641198 641218 641224 1.30 1.56 0.76 2.16 1.69 1.40 1.49 1.05 1.78 0.70 0.98 1.44 1.07 1.98 1.18 1.02 1.35 1.71 1.95 1.01 GROUP V: 250 mg/kg/day 0.84 1.34 0.86 1.48 2.06 0.67 1.37 1.18 1.47 0.82 1.04000 1.44667 0.89667 .87333 .64333 .03000 .40333 .31333 1.73333 0.84333 0.86 0.48 0.73 0.25 0.58 0.51 0.42 0.52 0.83 0.66 0.47 0.48 0.42 0.27 0.66 0.59 0.43 0.45 0.80 0.45 0.38 0.56 0.54 0.47 0.53 0.64 0.42 0.39 0.82 0.51 0.57000 0.50667 0.56333 0.33000 0.59000 0.58000 0.42333 0.45333 0.81667 0.54000 641061 641089 641102 641134 641137 641162 641190 641197 641200 641202 1.30 1.22 1.41 1.51 0.98 2.12 1.45 0.94 1.82 1.83 0.63 0.77 1.28 1.03 0.89 1.82 1.32 0.76 1.47 1.41 0.66 0.67 1.10 0.56 1.02 2.23 1.41 0.70 1.05 1.23 0.86333 0.88667 1.26333 1.03333 0.96333 2.05667 1.39333 0.80000 1.44667 1.49000 0.65 0.82 0.75 0.46 0.83 0.64 0.94 0.64 0.58 0.59 1.00 0.75 0.52 0.60 0.59 0.79 0.76 0.50 0.38 0.90 0.87 0.90 0.41 0.70 0.66 0.44 1.13 0.61 0.40 0.95 0.84000 0.82333 0.56000 0.58667 0.69333 0.62333 0.94333 0.58333 0.45333 0.81333 611 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL FORELIMB AND fflNDUMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS WEEK 12 FORELIMB GRIP STRENGTH (kg) ANIMAL MEAN OF NUMBER TRIAL 1 TRIAL 2 TRIALS TRIALS fflNDLIMB GRIP STRENGTH te) MEAN OF TRIAL 1 TRIAL2 TRIALS TRIALS GROUP VII: 1000 mg/kg/day 641064 641092 641143 641153 641167 641185 641189 641203 641213 641216 1.28 0.82 1.56 0.87 1.47 1.54 0.80 1.52 1.14 1.62 1.00 0.92 1.17 0.47 1.54 1.75 1.05 1.17 1.26 1.45 1.64 0.84 0.81 0.26 1.86 0.90 1.72 1.03 1.98 1.78 1.30667 0.86000 1.18000 0.53333 1.62333 1.39667 1.19000 1.24000 1.46000 1.61667 0.46 0.68 0.31 0.41 0.54 0.53 0.75 0.52 0.59 0.76 0.51 0.64 0.41 0.61 0.64 0.88 0.61 0.57 0.79 0.95 0.41 0.78 0.60 0.40 0.70 0.81 0.41 0.64 0.50 0.72 0.46000 0.70000 0.44000 0.47333 0.62667 0.74000 0.59000 0.57667 0.62667 0.81000 612 Company Sanitized. Does noS contain TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL FORELIMB AND fflNDLIMB GRIP STRENGTH ASSESSMENTS FOR MALE RATS RECOVERY FORELIMB GRIP STRENGTH (kg) fflNDLIMB GRIP STRENGTH (kg) ANIMAL MEAN OP NUMBER TRIAL 1 TRIAL2 TRIALS TRIALS MEAN OP TRIAL 1 TRIAL2 TRIALS TRIALS GROUP 1:01ng/kg/day 641083 641084 641085 641101 641105 641123 641154 641159 641165 641215 2.42 1.37 1.00 2.12 1.88 1.57 1.19 1.58 1.40 1.26 2.40 1.45 1.16 1.53 1.17 1.38 0.95 0:91 1.83 0.66 GROUP VII: 1000 mg/kg/day 2.19 1.17 1.24 2.37 1.60 1.30 1.05 1.55 1.85 1.05 2.33667 1.33000 1.13333 2.00667 1.55000 1.41667 1.06333 1.34667 1.69333 0.99000 0.99 1.00 0.94 1.05 0.96 0.65 1.06 0.75 0.70 0.61 0.72 0.74 0.81 0.77 0.99 0.77 0.94 0.69 0.47 0.70 0.73 0.61 0.97 0.70 0.99 0.51 0.86 0.73 0.38 0.60 0.81333 0.78333 0.90667 0.84000 0.98000 0.64333 0.95333 0.72333 0.51667 0.63667 641064 641092 641143 641153 641167 641185 641189 641203 641213 641216 1.56 1.72 1.45 1.76 1.12 0.99 0.71 1.48 1.82 1.54 1.76 1.60 1.19 1.29 1.10 1.67 1.62 1.14 2.08 1.71 0.91 1.36 1.77 0.70 0.97 1.53 1.22 1.54 2.18 1.11 1.41000 1.56000 1.47000 1.25000 1.06333 1.39667 1.18333 1.38667 2.02667 1.45333 0.64 0.84 0.38 0.63 0.55 0.77 0.72 0.86 0.66 0.56 0.59 0.82 0.70 0.51 0.77 0.45 0.90 0.51 0.75 0.55 0.48 0.64 0.84 0.67 0.69 0.61 0.69 0.62 0.69 0.64 0.57000 0.76667 0.64000 0.60333 0.67000 0.61000 0.77000 0.66333 0.70000 0.58333 613 Company Sanitized. Does not contain T8CA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL FORELIMB AND fflNDLIMB GRIP STRENGTH ASSESSMENTS FOR FEMALE RATS BASELINE FORE3LIMBGR]PSTRENCmince) ANIMAL MEAN OF NUMBER 1FRIAL1 TRIAL2 TRIAL 3 TRIALS HINDIJMBGRII'STRENGrTHfke) MEAN OF rRIALl TRIAL2 TRIAL 3 TRIALS GROUPn: ()mg/kg/d ay 641253 641281 641266 641294 641325 641331 641359 641364 641383 641400 0.75 0.78 0.87 0.54 0.76 0.45 0.67 0.72 0.44 0.60 0.83 0.53 0.52 0.69 0.73 0.44 0.93 0.50 0.71 0.47 GROUP IV: 50 mg/kg/day 0.54 0.88 0.85 0.56 0.61 0.79 0.76 0.61 0.76 0.58 0.70667 0.73000 0.74667 0.59667 0.70000 0.56000 0.78667 0.61000 0.63667 0.55000 0.38 0.40 0.31 0.23 0.30 0.28 0.27 0.29 0.21 0.36 0.50 0.31 0.40 0.31 0.30 0.26 0.33 0.21 0.22 0.27 0.37 0.29 0.33 0.41 0.25 0.19 0.40 0.27 0.15 0.37 0.41667 0.33333 0.34667 0.31667 0.28333 0.24333 0.33333 0.25667 0.19333 0.33333 641260 641298 641311 641312 641313 641336 641355 641361 641369 641396 0.30 0.89 0.99 0.60 0.73 0.47 0.87 0.53 0.47 0.49 0.57 0.47 0.76 0.39 0.69 0.77 0.75 0.85 0.54 0.36 GROUP VI: 250 mg/kg/day 0.80 0.69 0.50 0.51 0.52 0.78 0.62 0.78 0.74 0.48 0.55667 0.68333 0.75000 0.50000 0.64667 0.67333 0.74667 0.72000 0.58333 0.44333 0.29 0.26 0.20 0.28 0.31 0.32 0.31 0.29 0.28 0.21 0.34 0.27 0.26 0.21 0.35 0.45 0.33 0.26 0.32 0.34 0.21 0.35 0.23 0.33 0.29 0.43 0.23 0.40 0.22 0.48 0.28000 0.29333 0.23000 0.27333 0.31667 0.40000 0.29000 0.31667 0.27333 0.34333 641244 641251 641269 641292 641302 641362 641363 641375 641379 641398 0.59 0.88 0.57 0.81 0.66 0.53 0.44 0.58 1.02 0.36 0.47 0.80 0.80 0.84 0.58 0.67 0.81 0.68 1.19 0.47 0.48 0.65 0.65 0.73 0.75 0.70 0.67 0.85 1.04 0.80 0.51333 0.77667 0.67333 0.79333 0.66333 0.63333 0.64000 0.70333 . 1.08333 0.54333 0.24 0.33 0.35 0.31 0.63 0.39 0.27 0.25 0.39 0.51 0.31 0.54 0.36 0.52 0.25 0.43 0.20 0.24 0.37 0.38 0.25 0.37 0.33 0.46 0.26 0.27 0.35 0.30 0.27 0.42 0.26667 0.41333 0.34667 0.43000 0.38000 0.36333 0.27333 0.26333 0.34333 0.43667 614 Company Sanitized. not eonstaEn TSCA CB1 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL FORELIMB AND HINDLIMB GRIP STRENGTH ASSESSMENTS FOR FEMALE RATS BASELINE FORELIMB GRIP STRENGTH (kg) HINDLIMB GRIP STRENGTH (kg) ANIMAL MEAN OF NUMBER TRIAL 1 TRIAL 2 TRIALS TRIALS MEAN OF TRIAL 1 TRIAL2 TRIALS TRIALS GROUP Vin: 1000 mg/kg/day 641234 641256 641282 641352 641356 641366 641377 641385 641387 641399 0.45 0.85 0.63 0.58 0.95 0.71 0.45 0.44 0.46 0.51 0.64 1.05 0.84 0.56 0.83 0.67 0.58 0.43 0.80 0.67 0.61 1.01 0.65 0.76 0.77 0.73 0.71 0.83 0.61 0.65 0.56667 0.97000 0.70667 0.63333 0.85000 0.70333 0.58000 0.56667 0.62333 0.61000 0.36 0.32 0.47 0.21 0.30 0.21 0.29 0.49 0.39 0.31 0.21 0.39 0.37 0.20 0.27 0.32 0.48 0.32 0.25 0.33 0.21 0.50 0.37 0.24 0.44 0.30 0.32 0.24 0.30 0.40 0.26000 0.40333 0.40333 0.21667 0.33667 0.27667 0.36333 0.35000 0.31333 0.34667 615 Company Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL FORELIMB AND fflNDLIMB GRIP STRENGTH ASSESSMENTS FOR FEMALE RATS WEEK 12 ANIMAL NUMBER FOREELIMBGR]OPSTRENCmnks) MEAN OP 1FRIAL1 TRIAL 2 TRIAL 3 TRIALS HINDIJMBGRII'STRENG.THfke) MEAN OF TRIAL 1 TRIAL2 TRIAL3 TRIALS GROUP n: <)mg/kg/d ay 641253 641266 641281 641294 641325 641331 641359 641364 641383 641400 1.24 1.00 1.59 1.17 0.89 0.53 1.66 1.15 0.58 1.22 1.36 1.33 1.29 1.42 1.20 0.73 1.14 0.85 0.88 1.49 GROUP IV: 50 mg/kg/day 0.81 0.64 1.17 1.72 1.19 0.54 0.81 0.94 0.87 1.16 1.13667 0.99000 1.35000 1.43667 1.09333 0.60000 1.20333 0.98000 0.77667 1.29000 0.59 0.59 0.53 0.35 0.56 0.58 0.38 0.50 0.33 0.73 0.51 0.53 0.51 0.54 0.62 0.38 0.47 0.51 0.46 0.49 0.59 0.58 0.57 0.61 0.53 0.47 0.38 0.67 0.33 0.42 0.56333 0.56667 0.53667 0.50000 0.57000 0.47667 0.41000 0.56000 0.37333 0.54667 641260 0.91 0.56 0.86 0.77667 0.63 0.30 0.56 0.49667 641298 0.70 0.66 0.56 0.64000 0.66 0.71 0.42 0.59667 641311 0.95 1.42 1.59 1.32000 "0.49 0.29 0.26 0.34667 ^11 641312 0.60 0.71 0.74 0.68333 0.51 0.51 0.51 0.51000 641313 1.34 0.65 0.86 0.95000 0.60 0.51 0.50 0.53667 641336 0.86 1.02 0.83 0.90333 0.23 0.70 0.50 0.47667 641355 1.27 0.69 0.35 0.77000 0.32 0.41 0.48 0.40333 641361 1.43 0.89 1.18 1.16667 0.37 0.46 0.57 0.46667 641369 0.60 1.14 0.96 0.90000 0.34 0.31 0.28 0.31000 641396 1.35 1.11 1.26 1.24000 0.42 0.26 0.70 0.46000 GROUP VI: 250 mg/kg/day 641244 641251 641269 641292 641302 641362 641363 641375 641379 641398 0.99 0.35 0.56 0.97 1.23 1.08 0.99 1.64 1.52 1.03 1.14 0.40 0.32 0.95 0.66 1.56 0.85 1.52 0.76 1.73 1.32 0.35 0.62 0.85 0.66 1.59 0.71 1.60 0.52 1.82 1.15000 0.36667 0.50000 0.92333 0.85000 1.41000 0.85000 1.58667 , 0.93333 1.52667 0.45 0.56 0.39 0.53. 0.43 0.58 0.33 0.66 0.34 0.20 0.84 0.48 0.43 0.61 0.52 0.54 0.64 0.73 0.56 0.35 0.74 0.63 0.51 0.41 0.68 0.45 0.58 0.58 0.36 0.41 0.67667 0.55667 0.44333 0.51667 0.54333 0.52333 0.51667 0.65667 0.42000 0.32000 616 Company Sanitized. Does not contain TSCA C^ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL FORELIMB AND fflNDLIMB GRIP STRENGTH ASSESSMENTS FOR FEMALE RATS WEEK 12 FORELIMB GRIP STRENGTH (kg) fflNDLIMB GRIP STRENGTH (kg) ANIMAL MEAN OF NUMBER TRIAL 1 TRIAL 2 TRIALS TRIALS MEAN OF TRIAL 1 TRIAL2 TRIALS TRIALS GROUP Vni: 1000 nig/kg/day 641234 641256 641282 641352 641356 641366 641377 641385 641387 641399 0.74 1.10 0.76 1.21 0.96 1.32 0.95 0.75 1.30 1.24 0.46 1.32 1.83 1.29 0.54 1.60 1.56 0.90 1.46 0.86 0.32 0.40 1.29 1.42 0.75 1.43 0.48 0.79 1.51 1.40 0.50667 0.94000 1.29333 1.30667 0.75000 1.45000 0.99667 0.81333 1.42333 1.16667 0.43 0.50 0.65 0.57 0.56 0.35 0.45 0.36 0.27 0.61 0.51 0.54 0.62 0.40 0.49 0.36 0.53 0.56 0.26 0.58 0.34 0.40 0.51 0.40 0.61 0.32 0.47 0.65 0.38 0.50 0.42667 0.48000 0.59333 0.45667 0.55333 0.34333 0.48333 0.52333 0.30333 0.56333 617 Company Sanitized. Does not congaim TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INTWIDVAiLFORE:LIMB AN1OfflNDLD*ffi GRIPS'TRENGTH ASSES SMENTS F ORFEMA]LERATS RECO'VERY FORIiLIMBGR][P STRENGirH(kp) HIND]-JMBGRD' STRENGI"H(kR) ANIMAL MEAN OF NUMBER TRIAL1 TRIAL2 TRIAL3 TRIALS MEAN OF TRIAL1 TRIAL2 TRIAL3 TRIALS GROUP II: 0 nig/kg/day 641253 641266 641281 641294 641325 641331 641359 641364 641383 641400 1.44 0.97 0.84 1.12 1.64 0.46 1.48 0.87 0.91 1.10 1.33 1.00 0.69 1.43 1.62 0.49 1.18 0.71 0.83 0.93 1.41 0.85 0.63 1.04 1.35 0.44 1.25 0.88 0.8 0.46 1.39333 0.94000 0.72000 1.19667 1.53667 0.46333 1.30333 0.82000 0.84667 0.83000 0.58 0.48 0.80 0.65 0.66 0.52 0.43 0.68 0.44 0.46 0.44 0.37 0.53 0.80 0.86 0.52 0.48 0.52 0.63 0.49 0.54 0.43 0.51 1.07 0.58 0.65 0.42 0.56 0.66 0.59 0.52000 0.42667 0.61333 0.84000 0.70000 0.56333 0.44333 0.58667 0.57667 0.51333 GROUP VIII: lOOOmg/kg/day 641234 641256 641282 641352 641356 641366 641377 641385 641387 641399 0.62 1.42 1.39 1.19 a 1.04 0.82 0.97 0.91 1.34 0.47 0.72 1.11 a - 1.17 0.68 0.61 0.50 1.08 0.4 0.89 1.22 0.60 - 0.61 0.90 0.64 1.49 1.42 0.49667 1.01000 1.24000 0.89500 - 0.94000 0.80000 0.74000 0.96667 1.28000 0.55 0.75 0.45 0.46 - 0.95 0.45 0.56 0.47 0.58 0.41 0.61 0.77 0.61 - 0.95 0.39 0.67 0.34 0.81 0.47 0.68 0.68 0.56 - 0.76 0.51 0.60 0.53 0.72 0.47667 0.68000 0.63333 0.54333 - 0.88667 0.45000 0.61000 0.44667 0.70333 618 .Company Sanitized. Does not contain TSCA CBB H-24616: Subchromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX G INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR MALE RATS Group I: 0 mg/kg/day Animal Number Time Point I Iaiupulatioi1 Approach and Touch Auditory Stimulus Tail Pinch Ini Motor Activity Pupillary Response Defecation Urination 641083 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1 Recovery 0 0 0 0 1 1 641084 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1 Recovery 0 0 0 0 1 1 641085 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1 Recovery 0 0 0 0 1 1 641101 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1 Recovery 0 0 0 0 1 1 641105 Baseline 0 0 0 0 0 1 Week 12 0 0 -1 0 0 0 Recovery 0 0 0 0 0 1 641123 Baseline 0 0 0 0 1 1 Week 12 0 0 -1 0 1 1 Recovery 0 0 0 0 1 1 641154 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 1 1 Recovery 0 0 1 0 1 1 641159 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1 Recovery 0 0 0 0 1 1 641165 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 0 1 Recovery 0 0 0 0 1 1 641215 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 1 1 Recovery 0 0 0 0 0 1 620 CompMSf Sanitized. Does not co"Wn TSCA CSl! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUA.LFUNCTK)NALOB SERVATKONALBATTERY A55SESSMENTS FO]RMALERATS Group ffl : 50mg/kg/day i Aanipulatioli In[ Motor Activity Animal Number Time Point Approach and Touch Auditory Stimulus Tail Pinch Pupillary Response Defecation Urination 641055 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1 641056 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1 641073 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 1 1 641081 Baseline 0 0 0 0 1 1 Week 12 0 -1 0 0 0 1 641144 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1 641146 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 0 0 641178 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1 641198 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1 641218 Baseline 0 0 0 0 0 1 Week 12 0 -1 -1 0 0 1 641224 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1 621 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAJLFUNCTK)NALOB SERVATK3NALBA.TTERY AS1SESSMENTS FO]RMALERATS Group V: 250 mg/kg/d;iy i tianipulatfoii In. Motor Activi ty Animal Number Time Point Approach and Touch Auditory Stimulus Tail Pinch Pupillary Response Defecation Urination 641061 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1 641089 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1 641102 Baseline 0 0 0 0 1 1 Week 12 0 -1 -1 0 1 1 641134 Baseline 1 0 0 0 0 1 Week 12 0 0 0 0 0 1 641137 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1 641162 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 1 1 641190 Baseline 0 0 0 0 1 1 Week 12 0 0 -1 0 1 1 641197 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 1 1 641200 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1 641202 Baseline 0 0 0 0 1 0 Week 12 0 0 0 0 0 1 622 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR MALE RATS Group Vn: 1000 mg/kg/day___1^_la_ni_pu_la_ti_or_1 _____________In_M_<_at_or_A_c_tiv_ii_ty______ Animal Number Time Point Approach and Touch Auditory Stimulus Tail Pinch Pupillary Response D efecation Urination 641064 Baseline 0 0 0 0 1 1 Week 12 0 0 -1 0 1 1 Recovery 0 0 0 0 1 1 641092 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1 Recovery 0 0 0 0 1 1 641143 Baseline 1 1 1 0 1 1 Week 12 0 0 0 0 1 1 Recovery 0 0 0 0 1 1 641153 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1 Recovery 0 0 0 0 0 1 641167 Baseline 0 0 0 0 1 1 Week 12 0 0 -1 0 1 1 Recovery 0 0 0 0s 0 1 641185 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1 Recovery 0 0 0 0 1 1 641189 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 0 Recovery 0 0 0 0 1 1 641203 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1 Recovery 0 0 0 0 1 1 641213 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1 Recovery 0 0 0 0 1 1 641216 Baseline 0 0 0 0 Week 12 0 0 0 0 Recovery 0 0 0 0 0 1 1 1 1 0 623 f*V>f H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR FEMALE RATS Group II: Omg/kg/day Animal Number Time Point I ^[anipuladol1 Approach and Touch Auditory Stimulus Tail Pinch In1Motor Activity Pupillary Response Defecation Urination 641253 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1 Recovery 0 0 0 0 0 1 641266 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 1 1 Recovery 0 0 0 0 0 1 641281 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1 Recovery 0 0 0 0 0 1 641294 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 1 1 Recovery 0 0 0 0 1 1 641325 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 1 1 Recovery 0 0 0 0 1 1 641331 Baseline 0 0 -1 0 0 1 Week 12 0 0 0 0 1 1 Recovery 0 0 0 0 0 1 641359 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 1 1 Recovery 0 0 0 0 0 1 641364 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 1 1 Recovery 0 0 0 0 0 1 641383 Baseline 0 Week 12 0 Recovery 0 0 0 0 0 -1 0 0 0 0 1 1 1 1 1 1 641400 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 1 1 Recovery 0 0 0 0 1 1 624 Company Santfeed. Does not contain TSCA CB^ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAI.FUNCTK3NALOBSSERVATHONALBATTERY ASSSESSMENTS FOR FEMALE RATS Group IVr: 50mg/kg/day i klanipulatfoi1 Animal Number Time Point Approach and Touch Auditory Stimulus Tail Pinch Ini Motor Activity Pupillary Response Defecation Urination 641260 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1 641298 Baseline 1 1 1 0 0 1 Week 12 0 0 0 0 0 1 641311 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 0 1 641312 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 0 1 641313 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 0 1 641336 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 0 1 641355 Baseline 0 0 0 0 0 1 Week 12 1 1 0 0 0 1 641361 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 0 641369 Baseline 0 0 0 0 0 1 Week 12 0 0 -1 0 0 I 641396 Baseline 0 1 0 0 1 1 Week 12 0 0 0 0 0 1 625 G0mpalv santetl ^ not contain TSCA CK H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAI.FUNCTK3NALOB.SERVATKONALBATTERYASSSESSMENTS FOR FEMALE RATS Group VIE: 250mg/kg/d[ay I ^lanipulatiol1 Ini Motor Activity Animal Number Time Point Approach and Touch Auditory Stimulus Tail Pinch Pupillary Response Defecation Urination 641244 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1 641251 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 0 1 641269 Baseline 0 0 0 0 0 1 Week 12 0 0 -1 0 1 1 641292 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 0 0 641302 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1 641362 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1 641363 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 1 1 641375 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1 641379 Baseline 0 0 -1 0 0 1 Week 12 0 0 0 0 0 1 641398 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1 626 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENTS FOR FEMALE RATS Group VIOH: 1000 mg/k'day I klanipulatfoi1 In1Motor Activity Animal Number Time Point Approach and Touch Auditory Stimulus Tail Pinch Pupillary Response Defecation Urination 641234 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1 Recovery 0 0 0 0 0 1 641256 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1 Recovery 0 0 0 0 1 1 641282 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 1 Recovery 0 0 0 0 1 1 641352 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1 Recovery 0 0 0 0 0 1 641356 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 0 0 Recovery a - - - - 641366 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 0 1 Recovery 0 0 0 0 0 1 641377 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 0 1 Recovery 0 0 0 0 0 1 641385 Baseline 0 1 0 0 Week 12 0 0 0 0 Recovery 0 0 0 0 1 0 1 1 1 1 641387 Baseline 0 0 0 0 1 1 Week 12 0 0 0 0 1 1 Recovery 0 0 0 0 0 1 641399 Baseline 0 0 0 0 0 1 Week 12 0 0 0 0 0 1 Recovery 0 0 0 0 1 1 627 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX H -'III INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT 628 Sotted. Doe. not contain TSCACBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS ANIMAL NUMBER BASELINE SUCCESSIVE 10-MINUTE INTERVALS TOTAL GROUP I: Omg/kg/day 641083 332 274 264 76 6 641084 497 494 426 387 296 641085 395 304 241 127 0 641101 354 353 254 64 8 641105 458 456 303 162 4 641123 362 233 104 245 1 641154 372 277 196 195 95 641159 413 318 370 317 158 641165 345 340 165 31 0 641215 441 444 293 121 6 2 954 90 2190 0 1067 14 1047 13 1396 2 947 96 1231 12 1588 0 881 0 1305 GROUP III: 50mg/kg/day 641055 477 433 150 0 0 641056 381 348 83 2 0 641073 401 375 255 202 57 641081 388 330 267 76 5 641144 380 362 148 7 12 641146 404 350 303 182 0 641178 433 272 140 2 2 641198 419 276 44 27 249 641218 368 328 281 271 74 641224 430 245 27 2 33 2 1062 38 852 8 1298 0 1066 0 909 0 1239 0 849 24 1039 0 1322 0 737 GROUP V: 250mg/kg/day 641061 429 337 300 158 125 9 1358 641089 361 215 0 18 2 0 596 641102 403 310 292 85 94 0 1184 641134 359 246 129 257 188 19 1198 641137 410 336 409 336 287 306 2084 641162 388 337 20 5 3 54 807 641190 349 343 166 4Q 6 5 909 641197 335 236 214 92 22 2 901 641200 360 256 34 21 2 0 673 641202 335 251 93 1 11 9 700 629 Dae nnf e'-wfafn TSCA CBt H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OP MOVEMENT (sec) FOR MALE RATS BASELINE ANIMAL NUMBER SUCCESSIVE 10-MINUTE INTERVALS TOTAL GROUP VII: 1000 mg/kg/day 641064 452 258 240 8 2 4 964 641092 392 289 269 29 7 7 993 641143 445 383 339 312 300 147 1926 641153 394 281 213 5 13 3 909 641167 387 365 199 6 I 2 960 641185 348 138 306 111 0 0 903 641189 368 271 121 40 16 0 816 641203 344 341 285 17 II 641213 399 273 126 54 0 0 998 0 852 641216 250 329 173 66 0 0 818 630 ^PySrtteADoes.otco^TOCACB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS ANIMAL NUMBER 1 WEEK 12 SIJCCESSIVE 10-MINUTE;INTERVA1^S 2 3 4 5 6 TOTAL GROUP I: 0 mg/kg/day 641083 364 312 194 47 0 25 942 641084 455 337 347 111 1 139 1390 641085 428 192 187 179 199 150 1335 641101 369 311 264 254 18 142 1358 641105 473 438 402 288 282 200 2083 641123 331 384 251 258 224 130 1578 641154 368 320 294 228 193 168 1571 641159 442 383 315 290 213 2 1645 641165 407 339 214 184 44 4 1192 641215 514 424 409 357 350 242 2296 GROUP III: 50mg/kg/day 641055 367 256 150 176 128 197 1274 641056 477 402 301 185 . 223 194 1782 641073 394 418 314 220 7 163 1516 641081 402 424 369 406 236 11 1848 641144 417 329 312 74 21 87 1240 641146 405 247 209 111 11 14 997 641178 397 295 334 260 224 131 1641 641198 414 314 23 23 5 43 822 641218 353 334 348 300 325 46 1706 641224 460 409 290 329 151 5 1644 GROUP V: 250 mg/kg/day 641061 404 343 287 203 75 42 1354 641089 353 207 183 22 2 5 772 641102 465 384 273 6 3 5 1136 641134 341 166 250 255 39 10 1061 641137 443 363 318 159 225 183 1691 641162 305 190 206 4 19 160 884 641190 400 356 256 265, 255 241 1773 641197 404 289 92 6 10 114 915 641200 447 329 409 185 126 0 1496 641202 341 300 151 153 50 83 1078 631 fssi. D@e "*!* *;--,>,;.-> y>^*8 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS ANIMAL NUMBER WEEK 12 SUCCESSIVE 10-MINUTE INTERVALS TOTAL GROUP VII: 1000 mg/kg/day 641064 491 309 89 220 4 10 1123 641092 488 329 44 9 14 4 888 641143 452 405 389 330 289 245 2110 641153 449 354 257 71 10 15 1156 641167 337 117 32 15 112 46 659 641185 349 291 152 363 370 264 1789 641189 386 179 I 12 0 3 581 641203 411 154 II 11 40 641213 455 311 328 131 2 14 641 2 1229 641216 353 264 212 186 219 21 1255 632 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR MALE RATS ANIMAL NUMBER RECOVERY SUCCESSIVE 10-MINUTE INTERVALS TOTAL GROUP I: Omg/kg/day 641083 346 186 64 239 11 41 887 641084 360 258 223 121 41 0 1003 641085 407 219 229 125 20 118 1118 641101 297 263 152 99 146 74 1031 641105 332 289 182 196 60 8 1067 641123 383 304 213 89 51 7 1047 641154 492 323 307 105 413 359 1999 641159 489 389 378 312 283 151 2002 641165 493 386 243 148 252 76 1598 641215 328 216 162 74 9 142 931 ROUP VII: 1000 n 641064 401 222 123 139 31 144 1060 641092 .- 403 319 211 143 246 56 1378 641143 373 297 248 205 188 120 1431 641153 360 244 166 68 168 50 1056 641167 362 304 99 110 76 14 965 641185 236 104 123 113 50 63 689 641189 349 256 146 147 179 196 1273 641203 371 232 125 129 114 75 1046 641213 324 85 260 147 18 52 886 641216 329 262 105 106 72 116 990 633 Company ganISfeed. Dees not ewtafn JSCA cm H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS ANIMAL NUMBER BASELINE SUCCESSIVE 10-MINUTE INTERVALS TOTAL GROUP II: Omg/kg/day 641253 438 271 237 122 2 197 1267 641266 385 355 199 144 166 81 1330 641281 369 292 310 132 135 0 1238 641294 344 294 40 3 109 3 793 641325 395 289 65 164 137 0 1050 641331 494 346 78 35 24 2 979 641359 310 239 137 255 174 167 1282 641364 282 192 128 4 12 2 620 641383 423 327 106 2 I 6 865 641400 350 235 158 45 II 5 804 ROUPIV: ;iOmg/1 641260 395 308 236 263 81 21 1304 641298 431 361 281 33 225 209 1540 641311 411 379 150 1 32 0 973 641312 561 519 499 485 471 403 2938 641313 306 300 219 198 208 97 1328 641336 353 262 282 229 225 40 1391 641355 353 280 260 240 215 131 1479 641361 437 375 387 137 0 0 1336 641369 255 162 145 81 0 2 645 641396 333 283 284 266 244 291 1701 ROUPVI: 2ISO ~Jv/ mlil^e 641244 343 22 74 0 3 0 442 641251 401 313 294 187 219 104 1518 641269 343 377 267 211 384 365 1947 641292 361 237 256 292 43 11 1200 641302 482 376 331 300 275 130 1894 641362 353 271 82 4 84 4 798 641363 341 71 2 0 6 , 0 420 641375 439 336 90 251 160 109 1385 641379 414 323 229 344 149 15 1474 641398 436 250 46 326 90 7 1155 634 Company Santfad. Does not eonteM TSCA CB^ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS BASELINE ANIMAL NUMBER GROUP Vin: 641234 641256 641282 641352 641356 641366 641377 641385 641387 641399 SUCCESSIVE 10-MINUTE INTERVALS 1 2 3 4 5 6 1000 mg/kg/day 372 244 258 203 371 204 341 217 185 120 192 169 308 202 163 79 0 0 308 208 137 15 2 1 357 197 6 90 132 104 393 326 210 46 17 2 468 259 2 3 9 10 383 272 230 255 201 34 408 353 365 185 19 0 396 289 284 53 2 1 TOTAL 1652 1224 752 671 886 994 751 1375 1330 1025 635 Company SaiiStfced. Does not contain TSCA CBt H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OP MOVEMENT (sec) FOR FEMALE RATS ANIMAL NUMBER WEEK 12 SUCCESSIVE 10-MINUTE INTERVALS TOTAL GROUP II: Omg/kg/day 641253 362 299 143 41 2 25 872 641266 467 414 207 8 1 145 1242 641281 414 304 153 168 179 25 1243 641294 352 370 326 223 136 7 1414 641325 391 271 132 212 235 213 1454 641331 414 353 230 82 124 93 1296 641359 358 183 183 132 154 164 1174 641364 343 276 205 29 16 136 1005 641383 449 374 327 280 144 8 1582 641400 367 280 164 207 327 169 1514 ROUPIV: 50 mg/1 641260 410 317 203 220 128 16 1294 641298 426 363 393 333 171 0 1686 641311 384 307 252 154 2 3 1102 641312 425 362 123 303 173 4 1390 641313 366 303 205 79 7 208 1168 641336 368 284 244 149 233 179 1457 641355 373 333 289 242 210 67 1514 641361 486 455 272 13 17 0 1243 641369 349 211 36 153 54 0 803 641396 326 289 238 195 53 152 1253 "KDU/~\UTT.Dr \Vf I: 250 mg 641244 308 199 79 1 13 0 600 641251 298 174 118 187 78 86 941 641269 381 334 246 253 263 147 1624 641292 321 317 217 51 5 13 924 641302 523 401 277 352 96 60 1709 641362 328 225 158 120 40 11 882 641363 369 238 72 55 242 34 1010 641375 423 304 234 227 144 17 1349 641379 473 237 53 360 207 25 1355 641398 373 315 126 150 55 40 1059 636 A Does not eonW.R TSCA CBJ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENT (sec) FOR FEMALE RATS ANIMAL NUMBER WEEK 12 SUCCESSIVE 10-MINUTE INTERVALS TOTAL GROUP VDI: 1000 mg/kg/day 641234 422 275 267 129 237 85 1415 641256 346 84 80 289 86 57 942 641282 279 201 119 37 60 2 698 641352 376 317 311 267 187 227 1685 641356 357 162 25 17 204 25 790 641366 405 383 174 15 5 197 1179 641377 400 264 107 20 11 2 804 641385 404 314 65 113 9 14 919 641387 415 304 8 177 172 18 1094 641399 374 352 173 55 174 228 1356 637 , Does not cortaSn TSCA CB8 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL Mm'OR ACTTVUY A5SSESSME1STT: DURymoN o:F MOVEMENT (sec) FOR FEMALE RATS ANIMAL NUMBER 1 RECO VERY SlICCESSIVE 10-MINUTIiINTERVAlLS 2 3 4 5 6 TOTAL GROUP n: 0 mg/kg/day 641253 328 141 182 86 27 144 908 641266 390 308 202 217 283 99 1499 641281 363 193 114 114 112 87 983 641294 389 194 129 269 98 229 1308 641325 387 177 145 249 83 77 1118 641331 373 294 129 87 50 122 1055 641359 359 218 107 202 113 118 1117 641364 271 164 49 138 48 22 692 641383 378 167 182 120 100 85 1032 641400 270 172 117 238 130 91 1018 GROUP VIII: 1000 mg/kg/day 641234 327 233 88 118 92 103 961 641256 . 236 129 98 65 101 66 695 641282 346 127 56 115 2 14 660 641352 364 641356 a 237 - 126 - 200 - 210 - 122 - 1259 - 641366 429 164 167 105 134 177 1176 641377 414 126 74 37 48 244 943 641385 328 178 192 144 38 1 881 641387 411 144 169 40 94 228 1086 641399 398 210 185 127 118 71 1109 638 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 APPENDIX I INDIVIDUAL MOTOR ACTIVITY ASSESSMENT; NUMBER OF MOVEMENTS 639 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS ANIMAL NUMBER 1 BASELINE SIICCESSIVE 10-MINm'E INTERVA]^ 2 3 4 5 6 TOTAL GROUP I: 0 mg/kg/day 641083 133 125 155 36 6 641084 76 67 66 73 65 641085 122 116 125 95 0 641101 123 128 145 47 8 641105 114 126 129 92 4 641123 128 122 82 111 3 641154 118 123 127 129 76 641159 133 136 124 138 98 641165 147 125 116 38 4 641215 100 102 122 87 6 5 460 33 380 1 459 12 463 11 476 6 452 81 654 14 643 3 433 2 419 GROUP III: 50mg/kg/day 641055 80 87 75 0 0 1 243 641056 143 140 71 7 - 3 25 389 641073 125 116 132 96 36 8 513 641081 111 137 109 55 8 3 423 641144 130 131 100 10 25 1 397 641146 138 131 164 117 2 0 552 641178 109 142 90 5 2 3 351 641198 123 129 55 14 126 33 480 641218 144 148 136 165 86 2 681 641224 112 91 21 5 12 2 243 GROUP V: 250 mg/kg/day 641061 122 140 117 117 77 9 582 641089 141 127 0 12 3 1 284 641102 137 139 127 81 82 3 569 641134 125 138 97 135 94 26 615 641137 103 128 158 162 160 155 866 641162 127 132 15 3 7 34 318 641190 118 125 100 28, 5 13 389 641197 133 137 156 108 30 6 570 641200 135 129 31 17 2 2 316 641202 136 160 90 8 10 15 419 640 j^OIBponjBf aRlffisad. Does ''""9 c'''"?^ TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS ANIMAL NUMBER BASELINE SUCCESSIVE 10-MINUTE INTERVALS TOTAL GROUP VII: 1000 mg/kg/day 641064 114 107 81 17 5 6 330 641092 126 123 128 43 6 10 436 641143 119 142 136 132 173 132 834 641153 121 137 130 8 18 8 422 641167 144 139 125 11 3 2 424 641185 143 95 138 57 0 3 436 641189 155 136 93 27 20 0 431 641203 146 134 125 20 21 2 448 641213 137 160 117 52 0 0 466 641216 128 148 130 50 0 0 456 641 SSoispemsgaatod. Doss noS contain JSOA CB8 H-24616; Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS ANIMAL NUMBER 1 WEEK 12 SIICCESSIVE 10-MINimi INTERVALS 2 3 4 5 6 TOTAL GROUP I: 0 nig/kg/day 641083 162 145 122 40 3 28 500 641084 121 135 138 62 4 90 550 641085 125 88 91 120 89 97 610 641101 139 150 136 148 17 59 649 641105 111 115 125 129 131 100 711 641123 121 123 118 113 128 95 698 641154 140 130 117 129 114 104 734 641159 143 151 140 126 115 2 677 641165 138 133 149 112 26 7 565 641215 96 109 110 121 154 97 687 GROUP III: 50mg/kg/day 641055 132 129 80 99 73 106 619 641056 113 134 134 120 99 114 714 641073 128 103 144 98 8 88 569 641081 120 105 113 122 109 8 577 641144 118 139 162 34 15 66 534 641146 122 139 100 94 10 20 485 641178 137 129 152 126 116 94 754 641198 130 140 13 17 7 31 338 641218 135 138 153 130 161 53 770 641224 109 138 136 99 58 5 545 GROUP V: 250 mg/kg/day 641061 139 147 149 142 81 54 712 641089 151 139 82 18 4 7 401 641102 121 152 144 6 7 13 443 641134 147 87 121 119 35 9 518 641137 129 148 144 87 116 108 732 641162 133 101 100 8 26 85 453 641190 106 130 111 124 161 90 722 641197 152 167 62 6 17 110 514 641200 108 134 150 118 97 0 607 641202 140 150 114 111 48 71 634 642 QissusisssySanitized. Da not eontain TSCA W H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR MALE RATS ANIMAL NUMBER WEEK 12 SUCCESSIVE 10-MINUTE INTERVALS TOTAL GROUP Vn: lOOOmg/kg/day 641064 96 106 50 82 8 13 355 641092 117 116 12 12 14 10 281 641143 115 116 137 150 138 122 778 641153 122 127 136 44 9 12 450 641167 160 97 31 16 98 43 445 641185 125 132 61 144 142 125 729 641189 162 141 8 23 2 8 344 641203 151 65 15 10 33 17 291 641213 118 141 160 76 2 6 503 641216 136 138 98 114 136 20 642 643 Company SanRked. B@ not eantafn TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 iNDnmXJALI^[OTOR ftiCTIVITY ASSESS^IENT: N1JMBERO:F MOVEMENTS FO]RMALEDIATS ANIMAL NUMBER 1 RECO VERY SlrccEssrvE 10-MINUTEEINTERVAI^5 2 3 4 5 6 TOTAL GROUP I: 0]mg/kg/day 641083 141 122 39 114 16 39 471 641084 130 142 147 57 33 2 511 641085 120 121 120 76 25 55 517 641101 111 132 89 75 78 65 550 641105 148 150 86 125 36 12 557 641123 144 138 121 59 28 9 499 641154 62 62 44 16 53 57 294 641159 119 135 130 155 145 90 774 641165 113 115 96 61 115 45 545 641215 129 147 121 59 12 119 587 GROUP VII: 1000 mg/kg/day 641064 133 86 47 78 24 79 447 641092 117 115 122 80 96 30 560 641143 125 124 113 116 114 94 686 641153 157 167 125 70 125 58 702 641167 127 149 52 80 49 20 477 641185 129 87 110 40 50 74 490 641189 144 149 132 89 89 148 751 641203 158 134 93 84 97 86 652 641213 127 67 126 94 16 49 479 641216 141 141 79 75 62 71 569 644 SanBked. Does noS ecmfain TSCA CB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OP MOVEMENTS FOR FEMALE RATS ANIMAL NUMBER 1 BASELINE SIrCCESSIVE 10-MINUTE INTERVAI 2 3 4 5 6 TOTAL GROUP n: 0 mg/kg/day 641253 117 147 135 98 5 135 637 641266 153 148 138 100 99 75 713 641281 119 151 78 73 99 0 520 641294 141 154 30 4 89 4 422 641325 132 127 72 110 79 5 525 641331 99 132 75 28 25 5 364 641359 142 125 111 137 122 110 747 641364 141 127 105 13 18 4 408 641383 109 113 47 2 4 11 286 641400 144 137 121 56 21 6 485 GROUP IV: 50 mg/kg/day 641260 119 130 144 120 66 23 602 641298 115 134 124 37 114 117 641 641311 134 133 95 2 16 1 381 641312 56 65 61 56 51 64 353 641313 135 131 132 116 129 90 733 641336 115 131 126 108 123 38 641 641355 138 151 140 155 156 123 863 641361 117 111 109 83 0 3 423 641369 139 137 114 94 3 5 492 641396 130 116 138 148 137 148 817 GROUP VI: 250 mg/kg/day 641244 133 22 46 0 5 0 206 641251 130 132 123 140 124 102 751 641269 104 108 107 99 133 125 676 641292 148 137 126 140 44 12 607 641302 119 112 137 144 154 93 759 641362 163 178 89 9 74 11 524 641363 157 72 3 6 12 0 250 , 641375 120 119 60 101 125 82 607 641379 101 110 127 131 52 13 534 641398 113 99 31 120 53 10 426 645 mpanySanitized, Does no! eonfa?n TSCA CB( H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIV IDUAL3MOTOR ALCTIVITY ASSESS^IENT: N1JMBERC)F MOVEMENTS FOR FEMALE RATS ANIMAL NUMBER 1 BASELINE SlICCESSIVE 10-MINUTEEINTERVAl^s 2 3 4 5 6 . TOTAL GROUP vm: 1000 ing/kg/day 641234 115 135 144 136 138 162 830 641256 134 128 120 95 156 141 774 641282 166 138 94 73 2 4 477 641352 141 126 103 24 5 3 402 641356 148 105 5 49 75 91 473 641366 137 144 113 38 19 5 456 641377 117 122 5 2 10 7 263 641385 129 115 132 139 159 59 733 641387 126 135 142 147 20 3 573 641399 105 144 146 54 6 2 457 646 , not eontain TSCA CB) H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS ANIMAL NUMBER 1 WEEK 12 sue;CESSIVE 10-MINUTE; INTERVALSi 2 3 4 5 6 TOTAL GROUP n: 0 mg/kg/day 641253 144 113 125 46 6 24 458 641266 107 137 115 15 9 75 458 641281 150 142 83 106 105 35 621 641294 134 154 141 184 129 9 751 641325 152 129 88 139 128 146 782 641331 131 139 120 82 97 79 648 641359 142 147 164 129 122 118 822 641364 127 166 133 38 23 95 582 641383 120 132 128 120 114 5 619 641400 135 139 92 98 161 127 752 GROUP IV: 50 mg/kg/day 641260 111 133 136 130 109 12 631 641298 140 138 124 128 75 1 606 641311 158 140 135 121 6 3 563 641312 114 153 93 139 103 9 611 641313 127 157 142 57 12 146 641 641336 133 112 116 99 159 118 737 641355 144 127 145 154 130 56 756 641361 115 115 133 14 13 2 392 641369 151 159 35 123 70 4 542 641396 138 136 131 112 49 131 697 GROUP VI: 250 mg/kg/day 641244 130 102 53 4 17 0 306 641251 133 127 84 114 94 83 635 641269 129 120 110 93 107 81 640 641292 147 138 145 62 8 10 510 641302 104 128 122 149 64 43 610 641362 167 154 167 129 42 13 672 641363 157 124 70 52 155 39 597 , 641375 126 136 123 135 108 23 651 641379 116 118 41 133 123 32 563 641398 131 144 90 132 68 40 605 647 Sompasy Sanitfced. Does no! contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS FOR FEMALE RATS ANIMAL NUMBER WEEK 12 SUCCESSIVE 10-MINUTE INTERVALS TOTAL GROUP Vm: 1000 mg/kg/day 641234 127 132 128 102 154 74 717 641256 152 81 63 135 66 45 542 641282 152 145 88 27 54 3 469 641352 131 163 148 151 137 122 852 641356 152 136 29 28 132 31 508 641366 147 152 123 15 7 95 539 641377 142 111 86 18 21 6 384 641385 149 131 70 104 19 25 498 641387 130 107 12 85 86 27 447 641399 123 159 135 62 112 143 734 648 ^eeapaeySsaVSxsSB. o noSsontaIn VSW cw H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 IND rvrouALMOTOR AiCTTvTTY ASSESS]^IENT: N1JMBERC)F MOVEMENTS FOR FEMALE RATS ANIMAL NUMBER 1 RECO VERY SlrCCESSIVE 10-MINUTEiINTERVAl.S 2 3 4 5 6 TOTAL GROUP II: 0 mg/kg/day 641253 166 126 97 61 28 121 599 641266 137 126 134 134 133 77 741 641281 158 116 95 97 120 102 688 641294 131 131 106 141 92 130 731 641325 138 148 96 158 63 84 687 641331 136 122 90 78 62 82 570 641359 130 129 83 132 113 67 654 641364 141 124 51 100 62 24 502 641383 128 104 95 94 77 63 561 641400 168 132 86 121 92 88 687 GROUP VIII: 1000 mg/kg/day 641234 146 137 63 91 85 78 600 641256 154 106 80 75 83 85 583 641282 134 108 44 69 2 18 375 641352 165 147 99 123 147 94 775 641356 a - - - - - - 641366 126 105 89 67 90 101 578 641377 127 96 68 44 43 156 534 641385 161 116 120 124 53 3 577 641387 140 118 119 37 81 124 619 641399 144 153 133 106 107 78 721 649 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX J INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA 650 'Gasspany Sanitjzed, Boas not contain TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES ABBREVIATIONS: General: ADEQ CLOT DECK NSR NT NT-HEMOL OK QNS RNV > < adequate sample clotted decreased no sample received for testing not taken or not performed not taken due to hemolysis greater than or equal to moderate sample condition OK for testing quantity not sufficient result not valid greater than less than Individual COMD RBC HGB HCT MCV MCH MCHC RDW ARET WBC AMEU ANPR ALYM AMON AEOS ABAS ALUC ABLT AMSC PLT SPEC Hematology Values: - sample condition - red blood cell count - hemoglobin - hematocrit - mean corpuscular volume - mean corpuscular hemoglobin - mean corpuscular hemoglobin concentration - red cell distribution width - absolute reticulocyte count - white blood cell count - absolute neutrophil (all forms) - absolute neutrophil precursor - absolute lymphocyte - absolute monocyte - absolute eosinophil - absolute basophil - absolute large unstained cell - absolute blast leukocyte - absolute miscellaneous leukocyte - platelet count - special observations Individual Red Blood Cell Morphology Values: NORM - normal AHIS - anisocytosis MIC - microcytes MAC - macrocytes POLY - polychromasia HYPO - hypochromasia ECHI - echinocytes ACAN - acanfchocyfces TARG RX - HJB SPEC - - target cells rouleaux Howell-Jolly body special observations not observed or not examined; see whole blood sample condition 651 ^n^ ewfain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES ABBREVIATIONS: Individual NORM SM DB PC GP BP TOX VC SPEC -- White Blood Cell / Platelet Morphology Values: - normal - smudge white blood cells - Dohle bodies - platelet clumps (graded as 1 if present at any level) - giant platelets - bizarre platelets - toxic neutrophils - vacuolated cytoplasm - special observations - not observed or not examined; see whole blood sample condition Individual PHEM FLIP PICT PT APTT Coagulation Values: - plasma hemolysis - plasma lipemia - plasma icterus - prothrombin time - activated partial thromboplastin time Individual SHEM SLIP SICT AST ALT SDH ALKP BILI BUN CREA CHOL TRIG GLUC TP ALB GLOB CALC IPHS NA K CL PHEM FLIP PICT PFLU Serum and Plasma Chemistry Values: - serum hemolysis - serum lipemia - serum icterus - aspartate aminotransferase - alanine aminotransferase - sorbitol dehydrogenase - alkaline phosphatase - total bilirubin - urea nitrogen - creatinine - cholesterol - triglycerides - glucose - total protein - albumin - globulin - calcium - inorganic phosphorous - sodium - potassium - chloride - plasma hemolysis from blood sample for fluoride determination - plasma lipemia from blood sample for fluoride determination - plasma icterus from blood sample for fluoride determination - plasma fluoride 652 , Doe not eonfa'n TSCA Crt H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES ABBREVIATIONS: Individual Urinalysis Values: QUAL COL - quality (modifies color) color CLAR VOL - clarity volume XTOSM - urine osmolalifcy SG - pH - specific gravity the logarithm of the reciprocal of the hydrogen ion concentration UGLU - urine glucose KET - ketone UBIL - BLD - urine bilirubin blood URO - urobilinogen UFLU - urine fluoride UMTP - urine protein SPEC - special observations Individual EPIT UWBC URBC NCRY MICR SPER SPEC Urine Microscopic Examination - epithelial cells - urine white blood cells - urine red blood cells - normal crystals - microorganisms - sperm - special observations Values: KEY: Red Blood Cell Morphology Values, White Blood Cell / Platelet Morphology Values the exception of Platelet Clumps), and Special Observations: 1 - trace 2 few 3 - moderate 4 - many (with Urine Microscopic Values: EPIT/CASTS HCRY/MICR few moderate many I-10 II-50 >50 few moderate many l-25%/field 26-50%/field >50%/field SPERM/MPCUS 1 - 2 - .3 - 1-5 6-20 >20 653 S. De """<8fl,s^ ww ^R8? H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES NOTES: When individual animal data are not reported, it may be due to one of the following reasons or other reasons, all of which are explained in the study records: the sample was clotted (for hematology or coagulation data) (CLOT) there was insufficient sample for analysis (QNS) a valid result could not be obtained (RNV) the sample was not suitable for evaluation the animal died prior to sample collection no sample was available for analysis (NSR) When an individual observation was recorded as being less than a certain value, calculations were performed on half the recorded value. For example, if bilirubin was reported as <0.1, 0.05 was used for any calculations performed with that bilirubin data. 654 9. Ol9P< minf gy(^,, TOpwjn <wA H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL HEMATOLOGY VALUES FOR MALE RATS Animal Number COND RBC xl0''6/HL HGB g/dL Male, Group: 641069 641070 641094 641147 641149 641155 641172 641206 641214 641222 1-0 rog/kg - CLOT OK OK OK OK OK OK OK OK OK Day 44 NT 8.39 8.43 8.09 7.69 7.86 8.16 8.50 8.28 8.21 Male, Group: III - 50 mg/kg - Day 44 641055 641056 641073 641081 641144 641146 641178 641198 641218 641224 OK 8.07 OK 7.71 OK 8.00 OK 8.21 OK 7.79 OK 8.43 OK 8.10 OK 8.58 OK 7.55 OK 8.28 NT 15.6 14.7 15.3 14.8 14.5 14.9 15.9 14.5 15.1 15.6 14.6 14.9 14.9 15.5 15.1 14.5 14.6 14.6 14.6 HCT % NT 50.8 48.9 48.4 47.6 47.3 48.3 51.9 48.2 48.9 49.9 46.5 47.5 48.7 47.3 50.3 47.6 48.8 45.1 48.7 MCV fL NT 60.5 58.0 59.8 61.8 60.2 59.2 61.0 58.2 59.5 61.8 60.3 59.4 59.3 60.8 59.6 58,7 56.9 59.8 58.9 MCH PS NT 18.6 17.4 18.9 19.3 18.4 18.3 18.7 17.5 18.4 19.4 18.9 18.7 18.1 19.9 18.0 18.0 17.0 19.3 17.6 MCHC g/dL NT. 30.7 30.0 31.5 31.2 30.6 30.9 30.6 30.1 30.9 31.3 31.4 31.4 30.6 32.8 30.1 30.6 29.9 32.4 30.0 RDW ARET % x!0"3/AlL xl MT 11.2 11.9 11.2 11.3 11.5 10.6 11.4 11.9 12.5 11.2 12.1 11.3 11.6 10.8 11.6 10.9 11.9 12.4 11.1 NT 216. 261. 202. 182. 192. 199. 278. 241. 237. 198. 244. 195. 231. 203. 209. 176. 212. 268. 225. 655 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL HEMATOLOGY VALUES FOR MALE RATS Animal Number COND RBC xlO^/^L HGB g/dL Male, Group: V - 250 mg/kg - Day 44 641061 641089 641102 641134 641137 641162 641190 641197 641200 641202 OK 7.93 15.1 OK 7.46 14.1 OK 7.64 14.5 OK 7.75 14.1 OK 7.89 14.1 OK 7.32 14.0 OK 8.37 14.8 OK 8.28 15.3 OK 7.94 14.9 OK 7.75 15.6 Male, Group: VII - 1000 mg/kg - Day 44 641067 641077 641086 641095 641097 641132 641157 641166 641201 641223 OK 7.87 14.4 OK 7.71 14.3 OK 8.05 15.0 OK 8.17 14.5 OK 7.28 14.2 OK 7.52 13.5 OK 7.91 14.7 OK 8.27 14.9 OK 8.10 14.3 . OK 7.71 13.9 HCT % 49.9 45.1 45.6 45.8 45.4 44.2 48.9 51.4 47.5 50.0 46.5 45.5 47.4 47.7 45.8 45.5 47.3 47.5 47.3 44.5 MCV fL 62.9 60.4 59.7 59.1 57.5 60.4 58.4 62.1 59.9 64.4 59.1 59.0 58.9 58.4 62.8 60.6 59.8 57.4 58.4 57.7 MCH pg 19.0 18.9 19.0 18.2 17.8 19.2 17.7 18.5 18.7 20.1 18.3 18.6 18.6 17.8 19.5 17.9 18.6 18.0 17.6 18.0 MCHC g/dL 30.2 31.3 31.8 30.8 31.0 31.8 30.3 29.8 31.3 31.2 30.9 31.5 31.6 30.5 31.0 29.6 31.2 31.3 30.2 31.2 RDW ARET % xl0^3/(iL xl 11.6 11.1 11.3 11.3 11.6 12.3 11.1 12.1 11.2 10.9 11.8 12.2 10.9 13.0 11.6 13.5 11.2 11.7 12.5 12.5 254. 180. 214. 176. 189. 250. 163. 201. 205. 250. 267. 228. 180. 237. 179. 333. 187. 191. 196. 187. 656 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL HEMATOLOGY VALUES FOR MALE RATS Animal Number ANPR ; <10"3/^L A LYM xlO^S /^L K.MON xl0 "3 /ML A EOS 3tlO^ /111. A BAS >cl0"3 /HL ALUC > :10"3/HL ABLT x:LO~3/HL AMSC x]-0^3/ML PLT > slO^/AlL Male, Group: 1-0 mg/'kg - D ay 44 641069 NT NT NT NT NT NT NT NT NT 641070 NT 14 .59 0 .29 0 .12 0 .13 0.23 NT NT 1133 641094 NT 10.42 0.21 0 .08 0 .14 0.25 NT NT RNV 641147 NT 8 .97 0 .21 0 .04 0 .05 0.15 NT NT RNV 641149 NT 14 .25 0 .25 0 .16 0 .14 0.16 NT NT 1177 641155 NT 10 .97 0.25 0 .09 0 .09 0.12 NT NT 1063 641172 NT 10 .43 0 .14 0 .33 . 0 .08 0.23 NT NT KNV 641206 NT 8 .59 0 .25 0 .18 0 .13 0.49 NT NT 1271 641214 NT 8.72 0 .44 0 .53 0 .09 0.09 NT NT KNV 641222 NT 16 .97 0 .34 0 .12 0 .20 0.45 NT NT 1147 Male, Group: III - 50 ing/kg - Day 44 641055 NT- 13 .62 0 .30 0 .11 0 .14 0.11 NT NT 1080 641056 NT 14 .91 0 .45 0 .17 0 .09 0.16 NT NT RNV 641073 NT 17 .19 0 .29 0 .11 0 .11 0.26 NT NT RNV 641081 NT 14 .76 0 .31 0 .12 0 .12 0.21 NT NT 1331 641144 NT 16 .33 0 .52 0 .17 0 .21 0.33 NT NT RNV 641146 NT 18 .20 0 .35 0 .21 0 .14 0.30 NT NT 1244 641178 NT 9 .81 0 .34 0 .15 0 .06 0.20 NT NT 1133 641198 NT 12 .05 0 .42 0 .15 0 .06 0.20 NT NT 1095 641218 NT 10 .59 0 .25 0 .07 0 .07 0.30 NT NT 1232 641224 NT 12 .01 0 .57 0 .22 0 .04 0.30 NT NT RNV 657 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL HEMATOLOGY VALUES FOR MALE RATS Animal Number ANPR 3<10"3/^L AL YM atl0"3/ IlL A MOM xl0/3 /IlL A EOS ; cl0"3 /III. A BAS >clO'3 /HL AL UC ; cl0^3/ AlL ABLT x:LO^/fiL AMSC x3.0"3/iUL PLT > :10"3/(xL Male, Group: V - 250 mg/'kg - Da}/ 44 641061 641089 641102 641134 641137 641162 641190 641197 641200 641202 NT 15. 67 NT 13. 19 NT 14. 27 NT 12. 89 NT 8. 91 NT 13. 81 NT 15. 59 MT 14. 57 NT 12. 23 MT 17. 24 0 .35 0 .31 0 .34 0 .23 0.26 0 .37 0 .50 0 .35 0 .28 0 .25 0 .12 0 .09 0 .10 0 .08 0 .08 0 .05 0 .16 0 .07 0 .08 0 .16 0 .15 0 .13 0 .09 0 .14 0 .08 0 .11 0 .11 0 .18 0 .07 0 .15 0. 33 0. 22 0. 11 0. 15 0. 14 0. 21 0. 23 0. 22 0. 19 0. 18 NT NT 1173 NT- NT RMV NT MT RMV MT NT 1082 MT NT 1214 NT MT 1025 MT NT 900 NT NT 894 NT MT 822 MT NT 904 Male, Group: VII - 1000 ing/kg - Day 44 641067 NT. 19. 85 0 .53 0 .12 0 .29 0. 35 MT NT 1051 641077 NT 19. 17 0 .33 0 .12 0 .16 0. 95 NT MT 1150 641086 MT 20. 18 0 .76 0 .15 0 .23 0. 60 NT NT 898 641095 NT 16. 97 0 .25 0 .10 0 .14 0. 23 NT MT 1220 641097 MT 12. 57 0 .33 0 .08 0 .10 0. 14 MT NT 1094 641132 NT 14. 75 0 .26 0 .09 0 .16 0. 22 NT MT 1234 641157 NT 4. 79 0 .16 0 .50 0 .04 0. 05 MT NT RNV 641166 NT 12. 19 0 .37 0.07 0 .08 0. 19 NT NT 980 641201 NT 17. 79 0 .27 0 .13 0 .15 0. 16 NT NT 995 641223 NT 18. 52 0 .29 0 .09 0 .12 0. 20 MT NT 987 658 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL HEMATOLOGY VALUES FOR MALE RATS Animal Number COND RBC X10"6/^L HGB g/dL Male, Group: 641069 641070 641094 641147 641149 641155 641172 641206 641214 641222 1-0 nig/kg - OK OK OK OK OK OK OK OK OK OK Day 91 8.56 8.75 8.99 8.60 8.63 8.36 8.79 9.02 9.05 8.63 Male, Group: III - 50 nig/kg - Day 91 641055 641056 641073 641081 641144 641146 641178 641198 641218 641224 OK- 8.96 OK 8.25 OK 8.93 OK 10.05 OK 8.67 OK 8.82 OK 9.33 OK 8.76 OK 7.96 OK 8.66 15.1 16.1 15.7 16.4 16.2 15.2 15.7 16.5 15.4 15.4 16.8 14.8 16.0 17.5 15.9 15.7 16.3 14.7 15.2 15.2 HCT % 48.0 50.0 49.6 49.8 50.4 47.5 49.7 52.1 49.3 48.9 52.1 47.1 49.9 55.5 50.1 48.3 51.9 47.3 45.0 47.8 MCV fL 56.1 57.1 55.1 57.9 58.4 56.8 56.6 57.8 54.5 56.7 58.2 57.1 55.9 55.2 57.8 54.7 55.6 54.0 56.5 55.3 MCH pg 17.7 18.4 17.5 19.1 18.7 18.2 17.8 18.3 17.0 17.9 18.7 17.9 18.0 17.4 18.3 17.7 17.4 16.7 19.1 17.6 MCHC g/dL 31.5 32.2' 31.7 32.9 32.0 32.0 31.5 31.7 31.2 31.5 32.1 31.4 32.1 31.6 31.7 32.4 31.3 31.0 33.7 31.8 RDW ARET % xlO^/fiL xl 12.6 12.0 13.1 11.7 12.3 12.3 11.1 11.9 13.2 12.9 12.1 12.5 12.2 12.3 11.9 12.3 11.9 13.9 12.2 11.9 204. 147. 235. 153. 148. 178. 185. 233. 235. 205. 177. 223. 211. 215. 182. 163. 180. 243. 216. 237. 659 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL HEMATOLOGY VALUES FOR MALE RATS Animal Number COND RBC x.l0"6/p.li HGB g/dL Malei Group: V - 250 nig/kg - Day 91 641061 641089 641102 641134 641137 641162 641190 641197 641200 641202 OK 9.12 16.7 OK 8.16 14.8 OK 8.21 15.2 OK 8.73 15.9 OK 9.08 15.8 OK 8.36 15.2 OK 8.92 15.6 OK 9.01 16.1 OK 9.05 15.9 OK 8.66 16.7 Male, Group: VII - 1000 mg/kg - Day 91 641067 641077 641086 641095 641097 641132 641157 641166 641201 641223 OK 8.46 15.2 OK 8.05 14.1 OK 9.06 15.8 OK 8.28 14.6 OK 7.80 15.0 OK 8.30 14.8 OK 8.66 16.2 OK 9.14 15.7 OK 8.91 15.4 OK 8.33 15.0 HCT % 54.4 46.0 46.8 49.4 49.9 48.2 48.8 50.1 50.6 52.4 47.0 44.8 50.2 45.6 45.6 47.4 50.8 50.0 49.0 47.2 MCV L 59.7 56.4 57.1 56.6 55.0 57.7 54.7 55.6 55.9 60.5 55.6 55.7 55.5 55.1 58.5 57.1 58.6 54.7 54.9 56.6 MCH P3 18.3 18.2 18.6 18.2 17.5 18.2 17.4 17.9 17.6 19.3 18.0 17.6 17.4 17.7 19.2 17.8 18.7 17.1 17.3 18.0 MCHC g/dL 30.7. 32.2 32.5 32.2 31.8 31.6 31.9 32.1 31.4 31.9 32.4 31.5 31.4 32.1 32.8 31.2 31.9 31.3 31.5 31.7 RDW ARET % X.10"3 / IJ.L xl 12.7 12.3 12.0 11.3 12.2 12.3 12.5 12.3 12.1 11.3 11.7 13.9 11.6 13.0 13.2 12.7 11.5 12.6 12.3 13.5 228. 151. 125. 143. 152. 160. 110. 149. 179. 189. 76. 197. 113. 158. 168. 196. 132. 150. 102. 176. 660 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL HEMATOLOGY VALUES FOR MALE RATS Animal Number ANPR xlO^/fA ALYM xlO^a/AtL AMON xl0''3/UiL AEOS xlO"3/^L ABAS xlO"3/^L ALUC xlO^/jltL ABLT xlO"3/^L AMSC xlO"3/tL PLT xlO"3/tlL Male, Group: 1-0 ing/kg - Day 91 641069 NT " - 11.54 0.43 0.27 0.07 0.10 NT. NT 1259 641070 NT 9.05 0.29 0.10 0.05 0.09 NT NT 1133 641094 NT 7.00 0.29 0.14 0.11 0.11 NT NT 1110 641147 NT 8.04 0.25 0.06 0.05 0.09 NT NT 1083 641149 NT 9.57 0.35 0.09 0.04 0.05 NT NT 1177 641155 NT . 7.36 0.25 0.17 0.03 0.06 NT NT RNV 641172 NT 11.39 0.25 0.15 0.13 0.22 NT NT RNV 641206 NT 7.25 0.19 0.17 0.08 0.08 NT NT 1188 641214 NT 8.08 0.42 0.11 0.10 0.13 NT NT 879 641222 NT 12.53 0.36 0.14 0.10 0.14 NT NT 1221 Male, Group: III - 50 nig/kg - Day 91 641055 NT 8.96 0.21 0.17 0.13 0.15 NT NT 1018 641056 NT 10.67 0.41 0.21 0.06 0.08 NT NT 1022 641073 NT 12.18 0.29 0.17 0.13 0.17 NT NT 1063 641081 NT 8.17 0.43 0.08 0.06 0.12 NT NT RNV 641144 NT 8.80 0.51 0.23 0.07 0.15 NT NT RNV 641146 NT 12.79 0.22 0.17 0.10 0.10 NT NT 1032 641178 NT 11.05 0.41 0.13 0.11 0.14 NT NT 1162 641198 NT 10.18 0.34 0.19 0.06 0.08 NT NT 1006 641218 NT 9.83 0.40 0.15 0.05 0.14 NT NT RMV 641224 . NT 10.96 0.52 0.23 0.15 0.09 NT NT 1087 661 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL HEMATOLOGY VALUES FOR MALE RATS Animal Number 1IMPR xlO":1/1L AL YM 3i:10"3/ HL AMON xl0"3/ liL AEOS xl.0"3/ML AB AS 5clO^/ 111, ALUC ?cl0"3/ P.L ABLT x:1.0^3/^tL AMSC X]10^3/ftL PLT > !:10"3/^L Male, Group: V - 250 mg/'kg - Das,' 91 641061 641089 641102 641134 641137 641162 641190 641197 641200 641202 NT 9. 85 NT 11. 78 NT 7. 84 MT 9. 43 NT 8. 87 NT 12. 43 NT 15. 38 NT 7. 57 NT 10. 67 NT 12. 51 0. 21 0. 30 0. 30 0. 37 0. 28 0. 27 0. 39 0. 22 0. 37 0. 29 Male, Group: VII - 1000 ing/kg - Day 91 641067 641077 641086 641095 641097 641132 641157 641166 641201 641223 NT- 14. 44 NT 12. 86 NT 14. 35 NT 11. 17 NT 7. 44 NT 11. 58 NT 6. 69 NT 7. 53 NT 12. 14 NT 14. 10 0. 41 0. 26 0. 29 0. 45 0. 23 0. 31 0. 21 0.26 0. 31 0. 42 0.38 0.13 0.16 0.10 0.12 0.07 0.15 0.12 0.08 0.20 0.15 0.16 0.16 0.10 0.10 0.09 0.06 0.06 0.16 0.14 0. 03 0. 10 0. 03 0. 04 0. 11 0. 08 0. 09 0. 04 0. 13 0. 14 0. 16 0. 09 0. 16 0. 03 0. 11 0. 17 0. 05 0. 12 0. 15 0. 07 0. 08 0. 13 0. 09 0. 04 0. 10 0. 11 0. 14 0. 04 0. 15 0. 11 0. 23 0. 10 0. 18 0. 11 0. 11 0. 19 0. 05 0. 15 0. 12 0. 26 NT NT RNV NT- NT 1290 NT NT 845 NT NT 1052 NT NT 1217 NT NT 990 NT NT 850 NT NT 946 MT NT 717 NT NT 840 NT NT 830 NT NT 1137 NT NT 815 NT NT RMV NT NT RMV NT NT 1048 NT MT 909 NT NT 902 NT NT 792 NT NT 997 662 H-24616; Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL HEMATOLOGY VALUES FOR MALE RATS Animal Number COND RBC xl0''6/p.L HGB g/dL Male, Group: 641083 641084 641085 641101 641105 641123 641154 641159 641165 641215 1-0 nig/kg - OK OK OK OK OK OK OK OK OK OK Day 123 8.67 8.96 8.24 8.67 8.47 8.80 8.93 9.07 8.42 8.29 15.5 15.4 14.9 14.5 14.7 14.6 14.6 16.2 14.7 14.7 Male, Group: VII - 1000 mg/kg - Day 123 641064 641092 641143 641153 641167 641185 641189 641203 641213 641216 OK- 8.83 OK 8.10 OK 8.72 OK 8.83 OK 8.69 OK 8.57 OK 7.92 OK 7.97 OK 8.44 OK 8.67 15.9 14.1 14.8 14.4 15.2 15.4 13.3 14.2 14.4 14.5 HCT % 48.3 47.4 45.4 45.5 45.2 45.4 45.8 48.8 46.3 45.2 50.2 44.0 46.4 43.9 46.5 47.6 41.7 44.8 44.7 45.0 MCV fL 55.7 52.9 55.1 52.5 53.4 51.5 51.3 53.8 55.0 54.5 56.9 54.4 53.1 49.7 53.5 55.5 52.6 56.1 53.0 51.9 MCH pg 17.8 17.2 18.1 16.7 17.3 16.6 16.4 17.8 17.5 17.7 18.1 17.4 17.0 16.4 17.4 17.9 16.8 17.8 17.1 16.8 MCHC g/dL 32.0 32.532.8 31.8 32.5 32.3 31.9 33.2 31.8 32.5 31.7 32.0 32.0 32.9 32.6 32.3 31.9 31.7 32.3 32.3 RDW ARET % xl0^3/f2L xlO 12.9 13.5 12.7 13.6 13.6 14.1 13.6 13.4 13.1 13.8 13.1 14.7 14.7 14.1 13.4 13.1 13.5 13.2 12.5 14.8 228. 179. 154. 194. 175. 182. 171. 201. 166. 184. 186. 196. 158. 158. 176. 203. 154. 151. 170. 222. 663 H-24616: Subchronic Toxicity 90-Day Qavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL HEMATOLOGY VALUES FOR MALE RATS Animal Number ANPR xlO''3/nL ALYM xlO"3/tiL AMON xlO"3/p.L AEOS x!0"3/^L ABAS xlO"3/A(L ALUC xlO^/^L ABLT xlO"3/ftL AMSC xlO^/^L PLT xl0^3/^L Male, Group: 0 nig/kg - Day 123 641083 NT 7 .23 0 .32 0. 17 0.07 0. 17 NT NT 851 641084 NT 12 .99 0 .08 0. 39 0.10 0. 57 NT NT 1158 Sam SIG DIF SPE 641085 NT 11 .97 0 .38 0. 19 0.06 0. 37 MT NT 933 641101 NT 8 .96 0 .29 0. 10 0.14 0. 15 NT NT 1031 641105 NT 10 .76 0 .38 0.12 0.06 0. 21 NT NT 1206 641123 NT 10 .38 0 .22 0. 13 0.21 0. 18 NT NT 1115 641154 NT 9 .79 0 .35 0. 07 0.17 0. 18 NT NT RNV 641159 NT 14 .98 0 .47 0. 09 0.17 0. 11 NT NT RNV 641165 NT 13 .56 0 .29 0. 17 0.22 0. 31 NT NT RNV 641215 NT 10 .99 0 .39 0. 11 0.21 0. 09 NT NT 1123 Male, Group: VII 1000 mg/kg - Day 123 641064 NT 9 .43 0 .27 0.24 0.11 0. 15 NT NT RNV 641092 NT 11 .59 0 .36 0. 11 0.17 0. 12 NT NT 1083 641143 NT 10 .25 0. .33 0. 12 0.42 0. 15 NT NT 989 641153 NT 9 .81 0 .34 0. 08 0.31 0. 16 NT NT 837 641167 NT 12 .21 0 .37 0. 12 0.29 0. 17 NT NT 1027 641185 NT 13 .28 0 .30 0. 33 0.09 0. 11 NT NT 1062 641189 NT 11 .67 0 .31 0. 13 0.17 0. 23 NT NT 905 641203 NT 7 .43 0 .40 0. 07 0.26 0. 11 NT NT 911 641213 NT 10 .31 0 .28 0. 11 0.06 0. 12 NT NT 664 641216 NT 7 .45 0 .34 0. 14 0.12 0. 36 NT NT 860 664 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL HEMATOLOGY VALUES FOR FEMALE RATS Animal Muniber COMD RBC xlO^/dL HGB g/dL Female, Group: 641240 641245 641249 641257 641283 641290 641293 641335 641344 641384 11-0 OK OK OK OK OK OK OK OK OK OK nig/kg - Day 44 7.92 8.48 7.86 7.97 8.46 7.91 8.29 8.52 7.49 8.25 15.3 15.9 14.9 15.2 15.6 14.9 15.3 15.6 15.1 15.6 Female, Group: IV - 50 nig/kg - Day 44 641260 641298 641311 641312 641313 641336 641355 641361 641369 641396 OK. 7.97 OK 7.62 OK 7.66 OK 7.61 OK 7.69 OK 7.85. OK 7.63 OK 8.45 OK 8.07 OK 7.74 15.1 14.5 15.2 14.3 13.7 15.0 14.1 16.2 14.5 14.8 HCT % 47.9 50.4 47.1 51.0 51.3 48.5 49.1 50.5 48.5 49.5 47.0 46.9 48.1 45.0 44.6 47.8 45.6 51.6 47.9 47.9 MCV fL 60.5 59.5 59.9 64.0 60.6 61.3 59.2 59.2 64.8 60.0 58.9 61.6 62.8 59.1 58.1 60.9 59.7 61.1 59.4 61.9 MCH pg 19.3 18.7 19.0 19.0 18.4 18.8 18.4 18.3 20.1 18.9 19.0 19.0 19.9 18.7 17.9 19.1 18.5 19.2 18.0 19.1 MCHC g/dL 32.0 31.5. 31.7 29.7 30.4 30.7 31.1 30.9 31.1 31.4 32.2 30.8 31.6 31.7 30.8 31.3 30.9 31.3 30.2 30.8 RDW ARET % xlO"3/v.L xlO 11.2 10.7 11.0 11.1 10.6 11.5 10.9 11.5 10.8 10.6 11.2 12.2 10.9 11.6 10.7 11.1 10.8 12.4 11.1 11.6 251. 179. 175. 299. 244. 202. 171. 195. 250. 150. 263. 204. 174. 319. 192. 205. 194. 245. 202. 221. 665 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL HEMATOLOGY VALUES FOR FEMALE RATS Animal Number COND RBC xlO^-6/flL HGB g/dL Female, Group; VI - 250 ing/kg - Day 44 641244 641251 641269 641292 641302 641362 641363 641375 641379 641398 OK 7.52 14.6 OK 7.27 14.0 OK 8.34 14.8 OK 7.75 15.0 OK 7.63 14.7 OK 7.28 14.1 OK 7.54 13.7 OK 8.14 15.3 OK 7.31 14.2 OK 8.30 15.2 Female, Group: 641237 641275 641279 641299 641300 641314 641326 641327 641380 641390 VIII - OKOK OK OK OK OK OK OK OK OK 1000 mg/kg - 7.75 8.00 7.61 7.74 7.49 7.89 7.78 7.77 7.47 7.50 Day 44 14.7 15.2 14.9 15.5 1.4.2 14.8 15.0 14.8 14.3 15.1 HCT % 44.7 44.2 48.1 45.1 45.5 44.1 43.7 47.3 45.4 49.2 47.1 48.8 47.7 48.0 43.4 47.1 47.7 47.1 45.9 47.4 MCV L 59.4 60.8 57.7 58.2 59.6 60.5 58.0 58.2 62.2 59.3 60.9 60.9 62.7 62.0 57.9 59.6 61.3 60.6 61.4 63.3 MCH P? 19.4 19.2 17.8 19.4 19.3 19.3 18.1 18.8 19.4 18.3 19.0 19.0 19.6 20.1 18.9 18.7 19.2 19.1 19.2 20.1 MCHC g/dL RDW ARET % xlO"3/nL xlO 32.6 31.730.8 33.3 32.4 31.9 31.3 32.3 31.1 30.9 31.1 31.1 31.2 32.4 32.7 31.4 31.4 31.5 31.3 31.8 10.1 12.1 11.9 10.8 11.0 12.1 11.3 10.2 11.9 10.9 11.0 11.1 10.9 11.1 11.2 11.1 11.5 11.5 12.0 11.2 184. 225. 238. 235. 232. 238. 251. 189. 274. 194. 187. 242. 242. 284. 230. 238. 223. 197. 312. 255. 666 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL HEMATOLOGY VALUES FOR FEMALE RATS Animal Number ANPR xl ()"3/(iL A LYM xlO^-3 /IJ.L AM:ON xl0''3/ 111, A EOS xl.0"3 /^L A BAS ?tl0'-3 /ML A LUC >cl0"3 /P.L ABLT x:l.O"3/nL AMSC X]-0^3/^L PLT ? tlO'-3/nL Female, Group: II - 0 rng/kg - Day 44 641240 MT 15 .04 0. 30 0 .12 0 .13 0 .33 NT NT 1028 641245 NT 8 .65 0. 22 0.10 0 .08 0 .15 NT NT KNV 641249 NT 7 .66 0. 28 0 .14 0 .06 0 .10 NT NT 875 641257 NT 13 .19 0. 36 0.23 0 .10 0 .28 NT NT RNV 641283 NT 8 .15 0. 24 0 .13 0 .16 0 .16 MT NT 1419 641290 NT 12 .19 0. 32 0 .15 0 .12 0 .31 NT NT RNV 641293 NT 12 .04 0. 22 0 .24 0 .08 0 .59 NT NT 1190 641335 NT 12 .84 0. 34 0 .20 0 .15 0 .15 NT NT RNV 641344 NT 15 .26 0. 23 0 .13 0 .09 0 .16 NT NT 765 641384 NT 11 .76 0. 29 0 .26 0 .09 0 .24 NT NT RNV Female, Group; IV - 50 nig/kg - Day 44 641260 NT- 9 .70 0. 44 0 .22 0 .00 0 .00 NT NT RMV 641298 NT 15 .03 0. 17 0 .10 0 .06 0 .12 NT NT 1266 641311 NT 10 .17 0. 17 0 .06 0 .13 0 .17 NT NT RNV 641312 NT 8 .39 0. 09 0 .16 0 .04 0 .08 NT NT 1169 641313 NT 14 .92 0. 21 0 .09 0 .11 0 .24 NT NT 888 641336 NT 10 .73 0. 29 0 .05 0 .14 0 .20 NT NT 917 641355 NT 10 .67 0. 24 0 .06 0 .15 0 .19 NT NT 1208 641361 NT 12 .15 0. 40 0 .19 0 .14 0 .29 NT NT 977 641369 NT 14 .12 0. 43 0 .12 0 .09 0 .31 NT NT 1242 641396 . NT 8 .20 0. 28 0 .12 0 .05 0 .20 NT NT 1007 667 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL HEMATOLOGY VALUES FOR FEMALE RATS Animal Number ANPR xl()"3/(iL A:LYM xl0"3 /lL AMOM 3riO"3/fiL AEOS ? clO"3/AlL AB A3 ?ElO^/ ftL A:LUC >cl0"3 /II.-L, ABLT X:LO"3/^L AMSC x3.0"3/AlL PLT > ;10"3/(;L Female, Group: VI - 2 50 nig/tog - Da;/ 44 641244 NT 13 .86 0.34 0.12 0. 10 0 .15 MT MT 850 641251 MT 7 .33 0.20 0.39 0. 00 0 .00 NT MT 1110 641269 MT 13 .42 0.44 0.14 0. 18 0 .45 MT MT 1017 641292 NT 9 .72 0.20 0.20 0. 04 0 .15 MT NT RMV 641302 MT 10 .19 0.18 0.16 0. 12 0 .23 NT NT 994 641362 MT 7 .22 0.20 0.08 0. 07 0 .15 MT MT RMV 641363 MT 9 .07 0.17 0.13 0. 05 0 .13 NT NT RNV 641375 NT 15 .57 0.19 0.27 0. 12 0 .28 MT NT RMV 641379 MT 8 .01 0.21 0.15 0. 10 0 .11 NT MT 1128 641398 MT 16 .72 0.39 0.16 0. 12 0 .25 MT MT 1223 Female, Group: VIII - 1000 nig/kg - Day 44 641237 MT- 7 .90 0.15 0.16 0. 08 0 .12 NT NT 1324 641275 MT 8 .85 0.15 0.10 0. 06 0 .08 MT MT 1363 641279 MT 12 .46 0.15 0.13 0. 06 0 .23 MT NT 922 641299 NT 14 .15 0.29 0.13 0. 12 0 .18 NT MT 1211 641300 MT 11 .98 0.09 0.83 0. 04 0 .19 MT NT RNV 641314 MT 18 .62 0.37 0.16 0. 18 0 .35 NT NT 1217 641326 NT 9 .78 0.31 0.18 0. 11 0 .26 NT NT RNV 641327 NT 11 .69 0.27 0.07 0. 08 0 .24 MT MT RMV 641380 NT 9 .29 0.17 0.04 0. 06 0 .13 MT NT 1297 641390 MT 9 .57 0.22 0.10 0. 16 0 .21 MT NT 791 668 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL HEMATOLOGY VALUES FOR FEMALE RATS Animal Number COMD RBC xlO"6/^L HGB g/dL Female, Group: 641240 641245 641249 641257 641283 641290 641293 641335 641344 641384 11-0 mg/kg - Day 92 OK 8.45 OK 8.87 OK 8.52 OK 8.35 OK 8.56 OK 8.09 OK 8.76 OK 8.56 OK 8.37 OK 8.58 16.0 16.3 15.5 15.9 15.9 15.2 16.2 15.8 16.5 15.9 Female, Group: IV - 50 ing/kg - Day 92 641260 641298 641311 641312 641313 641336 641355 641361 641369 641396 OK' 8" .48" 15.9 OK 8.09 15.4 OK 8.16 16.0 OK 8.01 15.1 OK 8.14 14.3 OK 8.22 15.3 OK 8.24 15.4 OK 8.50 16.3 OK 8.28 14.8 OK 8.16 15.8 HCT % 49.3 51.6 49.5 49.7 50.5 47.6 50.8 49.0 52.5 49.8 49.4 47.9 49.4 46.3 45.3 49.4 47.5 50.1 47.1 48.8 MCV L 58.3 58.1 58.1 59.5 59.0 58.8 58.1 57.2 62.7 58.1 58.3 59.1 60.5 57.8 55.6 60.1 57.6 59.0 56.9 59.8 MCH pg 19.0 18.4 18.1 19.1 18.5 18.7 18.4 18.5 19.7 18.6 18.7 19.1 19.6 18.8 17.6 18.6 18.7 19.2 17.9 19.4 MCHC g/dL 32.5 31.6 31.2 32.0 31.4 31.9 31.8 32.3 31.4 31.9 32.1 32.2 32.4 32.6 31.6 30.9 32.5 32.5 31.5 32.4 RDW ARET % xlO"3/nL xl 10.7 10.8 11.3 10.6 10.6 11.6 10.8 10.8 10.6 10.0 10.6 11.0 10.2 10.3 10.4 10.7 10.6 11.5 10.4 10.2 155. 117. 179. 200. 215. 142. 138. 103. 187. 98. 144. 145. 117. 210129. 152. 138. 178. 127. 118. 669 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL HEMATOLOGY VALUES FOR FEMALE RATS Animal Number COND RBC xlO^/f^L HGB g/dL Female, Group: VI - 250 nig/kg - Day 92 641244 641251 641269 641292 641302 641362 641363 641375 641379 641398 OK 8.40 15.5 OK 7.96 14.8 OK 9.16 16.2 OK 8.25 15.7 OK 8.41 15.7 OK 7.72 14.8 OK 7.92 14.5 OK 8.34 15.5 OK 7.89 15.2 OK 8.81 15.9 Female, Group: VIII - 641237 OK- 641275 OK 641279 OK 641299 OK 641300 OK 641314 OK 641326 OK 641327 OK 641380 OK 641390 OK 1000 ing/kg - 8.01 8.32 8.24 8.05 7.92 8.25 8.17 8.36 8.02 8.15 Day 92 1--5 . - 2 15.9 15.8 16.2 14.4 15.5 15.8 15.8 15.7 16.2 HCT % 49.0 46.7 53.1 48.6 49.5 46.0 45.2 49.2 47.6 50.3 47.1 49.8 49.9 48.3 45.6 47.5 48.4 49.2 48.2 49.5 MCV fL 58.4 58.7 57.9 58.8 58.9 59.6 57.0 59.0 60.3 57.1 58.7 59.8 60.5 60.0 57.6 57.6 59.3 58.9 60.1 60.7 MCH pg 18.4 18.6 17.7 19.0 18.6 19.2 18.3 18.6 19.2 18.1 19.0 19.1 19.2 20.1 18.3 18.8 19.3 18.9 19.5 19.9 MCHC g/dL 31.6 31.6' 30.6 32.2 31.7 32.3 32.2 31.6 31.8 31.7 32.3 31.9 31.6 33.6 31.7 32.5 32.6 32.1 32.5 32.7 RDW ARET % xlO"3/(A xlO 9.8 10.6 11.0 10.4 10.4 10.7 10.7 10.8 11.1 10.6 10.8 10.5 10.7 10.4 10.6 10.5 10.9 11.2 10.4 11.0 170. 160. 176. 192. 162. 179. 151. 178. 188. 170. 208. 163. 152. 246. 153. 151. 170. 158. 136. 196. 670 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL HEMATOLOGY VALUES FOR FEMALE RATS Animal Number ANPR xl(1^3/UlL AL iYM xl0"3/ P.L A]MON xl0'"3 /ftL AEOS ?clO"3/(iL AB AS xl0"3/ H.L A:LUC ?clO^ /P.L ABLT ; clO"3/ML AMSC a :10"3/llL PLT ? clO^/nL Female, Group: II - 0 I ng/kg - Day 92 641240 641245 641249 641257 641283 641290 641293 641335 641344 641384 NT 6. 76 NT 5. 90 NT 5. 24 NT 8. 98 MT 6. 86 NT 9. 08 NT 8. 18 NT 6. 45 NT 7. 40 NT 7. 16 0 .19 0 .26 0 .21 0 .20 0 .31 0 .39 0 .17 0 .20 0 .16 0 .20 Female, Group: IV - 50 ing/kg - Day 92 641260 641298 641311 641312 641313 641336 641355 641361 641369 641396 NTNT NT NT NT 0.00 NT NT NT NT 9. 33 8. 34 6. 27 5. 44 9. 66 7. 82 6. 31 6. 04 8. 51 7. 35 0 .20 0 .16 0 .13 0 .15 0 .18 0 .26 0 .21 0 .19 0 .19 0.20 0.09 0.13 0.19 0.21 0.11 0.14 0.14 0.19 0.14 0.26 0.13 0.08 0.07 0.10 0.11 0.00 0.07 0.10 0.11 0.14 0. 07 0. 05 0. 05 0. 08 0. 14 0. 11 0. 09 0. 08 0. 05 0. 04 0. 09 0. 08 0. 05 0. 07 0. 04 0. 00 0. 03 0. .07 0. 05 0. 06 0 .09 0 .07 0 .05 0 .06 0 .13 0 .11 0 .10 0 .09 0 .06 0 .12 0 .16 0 .12 0 .03 0 .04 0 .08 0 .00 0 .05 0 .11 0 .07 0 .10 NT NT NT MT NT NT MT NT NT NT NT NT NT NT NT 0.00 MT NT NT NT NT NT MT MT NT NT NT NT MT NT NT NT NT NT NT 0.00 NT NT NT NT 1075 923 RNV KMV 1278 1238 989 1350 RNV 1010 1097 1024 1073 RNV RNV 993 RMV 963 1149 RNV 671 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL HEMATOLOGY VALUES FOR FEMALE RATS Animal Number AMPR xl(^"3/p.L ALYM xlO^/fiL AMON XlO^/fiL A EOS 3cl0"3 /AlL A BAS xl0"3 /HL A LUC 3cl0"3 /P.L ABLT sC10"3/HL AMSC T ElO^/nL PLT 5clO"3/^L Female, Group: VI - 2'50 mg/kg - I )ay 92 641244 641251 641269 641292 641302 641362 641363 641375 641379 641398 NT NT 0.00 NT NT NT NT NT NT NT 10.21 6.82 6.98 7.11 8.65 6.46 9.07 11.53 5.79 10.83 0.39 0.21 0.37 0.15 0.12 0.25 0.30 0.23 0.13 0.32 Female, Group: VIII - 641237 641275 641279 641299 641300 641314 641326 641327 641380 641390 0.00" NT NT NT NT NT NT NT NT . NT 1000 ing/kg - 5.24 6.30 8.42 8.61 14.50 9.55 9.93 7.79 5.65 8.38 Day 92 0.25 0.12 0.21 0.17 0..19 0.31 0.35 0.22 0.08 0.24 0 .14 0 .10 0 .12 0 .18 0 .10 0 .13 0 .17 0 .12 0 .08 0 .20 0 .12 0 .15 0 .19 0 .12 0 .11 0 .17 0 .13 0 .07 0 .06 0 .16 0 .06 0 .25 0 .00 0 .08 0 .14 0 .05 0 .08 0 .19 0 .09 0 .06 0 .00 0 .09 0 .06 0 .14 ' 0 .18 0 .09 0 .09 0 .06 0 .06 0 .07 0 .11 0 .23 0 .00 0 .07 0 .17 0 .10 0 .11 0 .31 0 .07 0 .12 0 .00 0 .09 0 .06 0 .39 0 .28 0 .10 0 .12 0 .05 0.11 0 .08 NT NT 0.00 NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT 850 1118 RNV 1071 1005 1058 999 1177 937 1168 RNV 1194 866 1017 927 1054 1132 1286 1136 837 672 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL HEMATOLOGY VALUES FOR FEMALE RATS Animal Number COND RBC xlO"6/^iL HGB g/dL Female, Group: 11-0 mg/kg - Day 124 641253 641266 641281 641294 641325 641331 641359 641364 641383 641400 OK 8.43 15.1 OK 8.16 14.8 OK 8.07 14.8 OK 7.93 15.0 OK 8.11 14.9 OK 8.50 15.5 OK 7.77 15.3 OK 8.79 15.4 OK 7.59 14.3 OK 7.85 15.2 Female, Group: VIII - 1000 nig/kg - Day 124 641234 641256 641282 641352 641356 641366 641377 641385 641387 641399 OK" OK OK OK NSR OK OK OK OK OK 7.83 7.67 7.96 8.66 MT 8.79- 8.54 7.50 8.18 7.86 14.4 14.8 15.8 16.0 NT 15.8 15.4 14.1 15.0 14.3 HCT % 46.5 45.6 44.2 46.8 45.1 46.9. 46.1 47.1 43.3 46.6 43.8 44.5 49.1 49.0 NT 48.3 47.4 42.7 45.5 44.1 MCV L 55.2 55.9 54.8 59.0 55.7 55.2 59.3 53.6 57.1 59.3 56.0 58.0 61.6 56.7 NT 55.0 55.5 57.0 55.6 56.1 MCH pg 17.9 18.2 18.4 18.9 18.3 18.2 19.7 17.5 18.9 19.4 18.4 19.2 19.8 18.5 NT 18.0 18.0 18.8 18.4 18.2 MCHC g/dL RDW ARET % xlO"3/(lL xlO 32.5 32.5' 33.5 32.0 32.9 33.0 33.2 32.7 33.1 32.7 32.8 33.2 32.1 32.7 NT 32.7 32.4 32.9 33.0 32.4 12.2 12.6 11.5 11.5 12.2 12.6 11.9 11.4 12.2 11.4 11.8 11.4 12.2 11.7 NT 12.4 11.9 12.0 11.7 11.6 195. 202. 157. 185. 166. 157. 157. 180. 155. 202. 123. 156. 229. 164. NT 186. 186. 151. 170. 140. 673 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL HEMATOLOGY VALUES FOR FEMALE RATS Animal Number ANPR xlO "3/nL ALYM xlO"3/(lL AMON xl0^3/(L AEOS xl0^3/iL ABAS xl0^3/^L ALUC x!0"3/iuL ABLT xl0^3/(iL AMSC X.10"3/HL PLT xl0"3/(ri-. Female, Group: 641253 641266 641281 641294 641325 641331 641359 641364 641383 641400 11-0 NT NT NT NT MT 0.00 NT NT NT NT ing/kg - Day 124 13.25 8.08 8.33 8.24 5.27 13.66 9.66 9.40 9.32 8.28 0.40 0.23 0.27 0.41 0.32 0.32 0.20 0.40 0.31 0.21 Pemale, Group: VIII - 641234 641256 641282 641352 641356 641366 641377 641385 641387 641399 NTNT 0.00 NT NT NT NT NT NT . NT 1000 ing/kg - 6.61 6.98 11.48 9.13 NT 8.86 7.86 11.68 12.17 6.61 Day 124 0.20 0.24 0.52 0.22 NT 0.51 0.17 0.33 0.33 0.29 0.18 0.11 0.19 0.09 0.15 0.48 0.07 0.21 0.08 0.08 0.13 0.06 0.13 0.12 NT 0.13 0.14 0.09 0.13 0.16 0.17 0.05 0.12 0.15 0.09 0.00 0.05 0.06 0.07 0.15 0.21 0.12 0.00 0.10 NT 0.16 0.06 0.04 0.05 0.06 0.20 0.25 0.10 0.36 0.27 0.00 0.11 0.18 0.17 0.22 0.14 0.14 0.00 0.09 NT 0.18 0.12 0.19 0.38 0.19 NT NT NT NT NT 0.00 NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT 787 RNV RNV 947 1007 757 1096 RNV 1112 971 957 1168 1089 1033 NT 1041 794 934 898 948 674 -'ttd Wi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR MALE RATS Animal MORM ANIS MIC Number Male, Group: I - 0 ing/kg - Day 44 641069 641070 641094 641147 641149 641155 641172 641206 641214 641222 Male, Group: III - 641055 641056 641073 641081 641144 641146 641178 641198 641218 641224 50 ing/kg - Day 44 MAC POLY HYPO ECHI ACAM TARG 3. l 443423132112121-------3324211221-------4322---- 675 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR MALE RATS Animal NORM ANIS MIC Number Male, Group: V - 250 ing/kg - Day 44 641061 641089 641102 641134 641137 641162 641190 641197 641200 641202 Male, Group: VII - 641067 641077 641086 641095 641097 641132 641157 641166 641201 641223 1000 ing/kg - Day 44 MAC POLY HYPO ECHI ACAN TARG 2 2 22243321231------ 21-- 2331 311323------ 24 123---- 676 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR MALE RATS Animal Number SPEC Male, Group: I - 0 ing/kg - Day 44 641069 641070 641094 641147 641149 641155 641172 641206 641214 641222 4-HEMOGLOBIN CRYSTAL 4-HEMOGLOBIN CRYSTAL 4-HEMOGLOBIN CRYSTAL 4-HEMOGLOBIN CRYSTAL; 1-SPHEROCYTE Male, Group: 641055 641056 641073 641081 641144 641146 641178 641198 641218 641224 III - 50 mg/kg - Day 44 4-HEMOGLOBIN CRYSTAL 4-HEMOGLOBIN CRYSTAL 677 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR MALE RATS Animal Number SPEC Male, Group; V - 250 ing/kg - Day 44 641061 641089 641102 641134 641137 641162 641190 641197 641200 641202 4-HEMOGLOBIN CRYSTAL 2-HEMOGLOBIN CRYSTAL 4-HEMOGLOBIN CRYSTAL Male, Group: VII - 1000 ing/kg - Day 44 641067 641077 641086 641095 641097 641132 641157 641166 641201 641223 1-SPHEROCYTE 4-HEMOGLOBIN CRYSTAL 1-SPHEROCYTE 4-HEMOGLOBIN CRYSTAL 1-SPHEROCYTE 678 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR MALE RATS Animal NORM AMIS MIC Number Male, Group: I - 0 ing/kg - Day 91 641069 641070 641094 641147 641149 641155 641172 641206 641214 641222 Male, Group: 641055 641056 641073 641081 641144 641146 641178 641198 641218 641224 III - 50 mg/kg - Day 91 --- -11 MAC POLY HYPO ECHI ACAN TARG 2 1 " 1 21 1211 1 1111 -- -- -- 11-- 1 1 2111 111 -- -- -- 1 2121-- 679 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR MALE RATS Animal NORM AMIS MIC Number Male, Group: V - 250 ing/kg - Day 91 641061 641089 641102 641134 641137 641162 641190 641197 641200 641202 Male, Group: VII - 641067 641077 641086 641095 641097 641132 641157 641166 641201 641223 1000 mg/kg - Day 91 MAC POLY HYPO ECHI ACAN 1- 2 2 2 1 1 1 1 1 2 2 1 1 1 1 1 2 1 1 2 1 1 1 1 TARG 680 ''yy H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR MALE RATS Animal Number SPEC Male, Group: I - 0 nig/kg - Day 91 641069 641070 641034 641147 641149 641155 641172 641206 641214 641222 1-SPHEROCYTE 1-SPHEROCYTE Male, Group: 641055 641056 641073 641081 641144 641146 641178 641198 641218 641224 III - 50 nig/kg - 1-SPHEROCYTE 1-SPHEROCYTE 2-SPHEROCYTE 1-SPHEROCYTE 1-SPHEROCYTE Day 91 681 IIH H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR MALE RATS Animal Number SPEC Male, Group: V - 250 mg/kg - Day 91 641061 641089 641102 641134 641137 641162 641190 641197 641200 641202 1-SPHEROCYTE 1-SPHEROCYTE Male, Group: VII - 1000 ing/kg - 641067 641077 641086 641095 641097 641132 641157 641166 641201 641223 2-SPHEROCYTE 2-SPHEROCYTE 1-SPHEROCYTE 1-SPHEROCYTE 1-SPHEROCYTE 1-SPHEROCYTE Day 91 682 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR MALE RATS Animal NORM AMIS MIC Number Male, Group: I - 0 nig/kg - Day 123 641083 641084 641085 641101 641105 641123 641154 641159 641165 641215 Male, Group: VII - 641064 641092 641143 641153 641167 641185 641189 641203 641213 641216 1000 nig/kg - Day 123 MAC POLY HYPO ECHI ACAN 1 1 1 1 2 1 .1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 TARG 683 v"^vMs^y^ V''''y'v^,f H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR MALE RATS Animal Number SPEC Male, Group: I - 0 nig/kg - Day 123 641083 641084 641085 641101 641105 641123 641154 641159 641165 641215 Male, Group: VII - 641064 641092 641143 641153 641167 641185 641189 641203 641213 641216 1000 ing/kg - Day 123 684 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR FEMALE RATS Animal MORM ANIS MIC Number Female, Group: II - 641240 641245 641249 641257 641283 641290 641293 641335 641344 641384 0 mg/kg - Day 44 Female, Group: IV - 50 mg/kg - Day 44 664411226908 --- 641311 641312 641313 641336 641355 641361 641369 641396 MAC POLY HYPO ECHI ACAM TARG 685 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR FEMALE RATS Animal NORM ANIS MIC Number Female, Group: VI - 641244 641251 641269 641292 641302 641362 641363 641375 641379 641398 250 ing/kg - Day 44 Female, Group: VIII - 641237 641275 641279 641299 641300 641314 641326 641327 641380 641390 . -- 1000 mg/kg - Day 44 MAC POLY HYPO ECHI ACAN TARG 686 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR FEMALE RATS Animal Number SPEC Female, Group: II - 0 mg/kg - Day 44 641240 641245 641249 641257 641283 641290 641293 641335 641344 641384 Female, Group: IV - 50 mg/kg - Day 44 SB 641260 4-HEMOGLOBIN CRYSTAL 641298 0 641311 Q 641312 4-HEMOGLOBIN CRYSTAL S3, 641313 3" 641336 -4 641355 641361 0 641369 > 641396 G3 687 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR FEMALE RATS Animal Number SPEC Female, Group: VI - 250 ing/kg - Day 44 641244 641251 641269 641292 641302 641362 641363 641375 641379 641398 4-HEMOGLOBIM CRYSTAL Female, Group: VIII - 1000 mg/kg - Day 44 641237 641275 641279 641299 641300 641314 641326 641327 641380 641390 4-HEMOGLOBIM CRYSTAL 4-HEMOGLOBIN CRYSTAL 4-HEMOGLOBIN CRYSTAL 4-HEMOGLOBIN CRYSTAL 688 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR FEMALE RATS Animal NORM ANIS MIC Number Female, Group: II - 641240 641245 641249 641257 641283 641290 641293 641335 641344 641384 0 ing/kg - Day 92 Female, Group: IV - 50 mg/kg - Day 92 641260 641298 641311 641312 641313 641336 641355 641361 641369 641396 MAC POLY HYPO ECHI ACAN TARG 121-- 31 2 1 1 2111---- 1 1 1 -- 1 1 -- --- '1 11 11 1 21 1-- 689 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR FEMALE RATS Animal NORM ANIS MIC Number Female, Group: VI - 250 mg/kg - Day 92 641244 641251 641269 641292 641302 641362 641363 641375 641373 641398 Female, Group: VIII - 641237 641275 641279 641299 641300 641314 641326 641327 641380 641390 1000 mg/kg - Day 92 MAC POLY HYPO ECHI ACAN 3 1 2 1 2 1 1 1 1 2 1 2 1 1 2 1 2 1 2 1 2 1 1 TARG 690 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR FEMALE RATS Animal Number SPEC Female, Group: II - 641240 641245 641249 641257 641283 641290 641293 641335 641344 641384 0 mg/kg - Day 92 Female, Group: IV - 50 mg/kg - Day 92 641260 641298 641311 641312 641313 641336 641355 641361 641369 641396 1-SPHEROCYTE 691 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR FEMALE RATS Animal Number SPEC Female, Group: VI - 250 mg/kg - Day 92 641244 641251 641269 641292 641302 641362 641363 641375 641379 641398 1-SPHEROCYTE Female, Group: VIII - 1000 mg/kg - 641237 641275 641279 641299 641300 641314 641326 641327 641380 641390 1-SPHEROCYTE Day 92 692 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR FEMALE RATS Animal NORM AMIS MIC Number Female, Group: II - 641253 641266 641281 641294 641325 641331 641359 641364 641383 641400 0 nig/kg - Day 124 Female, Group: VIII - 641234 641256 641282 641352 641356 641366 -- 641377 641385 641387 641399 1000 ing/kg - -- Day 124 MAC POLY HYPO ECHI ACAN 2 2 1 1 1 1 1 1 2 1 2 1 1 3 1 1 1 3 1 1 1 3 1 2 1 3 2 1 TARG 693 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL RED BLOOD CELL MORPHOLOGY VALUES FOR FEMALE RATS Animal Number SPEC Female, Group: II - 641253 641266 641281 641294 641325 641331 641359 641364 641383 641400 0 mg/kg - Day 124 Female, Group: VIII - 641234 641256 641282 641352 641256 641366 641377 641385 641387 641399 1000 mg/kg - Day 124 694 @ P s 1 5 0 0 8 3 ? S S o> 8 ? j H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVII3UAL WHITE BLOOD CELL / PLATELET MORPHOLOGY{ VALUES FOR MALE RATS Animal NORM SM DB PC GP BP TOX VC SPEC Number Male, Group: 1-0 nig/kg - Day 44 664411006790 NORMAL -- ------ -- -- -- -- -- -- 641094 - 641147 - -.- 1 ' 1 ADEQ PLATEL ADEQ PLATEL 641149 NORMAL - ,, 641155 NORMAL -- ,, -- -- 641172 -- - 1 --- -- -- DECR PLATEL 641206 NORMA--L -- -*-. .... -- -- 641214 -~ 1 DECR PLATEL 641222 NORMAL Male, Group: III - 50 mg/hg - Day 44 641055 641056 641073 641081 641144 641146 641178 641198 641218 641224 -- NORMAL NORMAL NORMAL NORMAL NORMAL - -- -- . -- -.- -- -- :: 1 1 1 1 ADEQ PLATEL DECR PLATEL ADEQ PLATEL - -- -- -- -- 1 ADEQ PLATEL 695 0 $ n s *s s51 s & |H 3 0 3 S 3" S~i 2 9> 0 s. H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDXH\L WHITE BLOOD CELL / PLATELET MORPHOLOGYf VALUES FOR MALE RAT S Animal NORM SM DB PC GP BP TOX VC SPEC Number Male, Group: V - 250 ing/kg - Day 44 641061 NORMAL ,,. 641089 -- -- -- 1 -- -- -- -- ADEQ PLATEL 1 DECR PLATEL 641102 641134 NORMA--L -- -- 641137 NORMAL -- - -- -- -- -- -- 641162 NORMAL -- -- -- -- -- -- -- 641190 NORMAL -- -- -- -- -- -- -- 641197 NORMAL -- - ,, -- -- -- - 641200 -- -- -- ,, 1 -- -- -- 641202 NORMA--L -- -,, -- -- -- -- -- -- -- -- -- -- Male, Group: VIX - 1000 mg/kg - Day 44 641067 NORMAL ,, 641077 641086 NORMA--L -- - 1 -- -- -- 641095 NORMAL ..,, - -- -- 641097 NORMAL -- -- ,, -- -- -- 641132 NORMAL -- -- -- -- -- -- -- 641157 641166 -- NORMAL -- -- 1 DECR PLATEL 641201 NORMAL -- -- -- -- -- -- -- 641223 NORMAL -- -- -- -- -- -- -- ,, ,, ^ 696 '^S^^fS x ' 'w H-24616: Subchironic Toxicity 90-Day Gavage S tudy in Rats with One-Generation Reproductive Evalinations INDIVIDI.JAL WHITE BLOOD CELL / PLATELET VTORPHOLOG'1i VALUES FOR MALE RAT s Animal NORM SM DB PC GP BP TOX VC SPEC Number Male, Group: I - 0 ing/kg - Day 91 III 8Q 641069 NORMAL 641070 NORMAL - - -- -- -- ii 641094 NORMAL --- --- --- --- --- -- -- --- 3 8 641147 NORMAL -- -- -- -- -- -- -- 641149 NORMAL -- -- -- -- -- -- -- 641155 641172 -- -- -- 1 1 ADEQ PLATEL ADEQ PLATEL 641206 NORMA--L -- - -- - -- -- -- -- --- p, 641214 641222 -- -- -- -- 1 -- -- -- 1 -- -- -- -- -- -- -- ^ (6 Male, Group: - 50 nig/kg - Day 91 a 3 641055 NORMAL- a 641056 NORMAL - --. - 641073 NORMAL -^ -~ ,,- ,, - -- 3 a 641081 641144 -- -- -- 1 1 -- -- -- AADDEEQQ PPLLAATTEELL --' 3 641146 NORM-A-L -- -- 641178 -- ,, -- --. 1 a 0 > 641198 641218 NORMAL -- 1 -- -- ADEQ PLATEL 0 641224 NORMA--L -- - sa - -- ,,,,. - -- 697 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL WHITE BLOOD CELL / PLATELET MORPHOLOGY VALUES FOR MALE RATS Animal NORM SM DB PC GP BP TOX VC SPEC Number Male, Group: V - 250 ing/kg - Day 91 641061 641089 641102 641134 641137 641162 641190 641197 641200 641202 ,, NORMAL NORMAL NORM-A-L NORMA- -L NORMAL NORMAL NORMAL Male, Group: VII - 1(000 ing/kg - 641067 641077 641086 641095 641097 641132 641157 641166 641201 641223 NORMALNORMAL NORMAL - NORMA--L NORMAL NORMAL NORMAL NORMAL Day 91 DECR PLATEL DECR PLATEL ADEQ PLATEL 698 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ;5BK ' s 3 S S (9 1p, 0 Q SB w I 0 SSOt 5, ^ Q v a INDIV:IDUAL WHITE BLOOD CELL / PLATELET MORPHOLOG1C VALUES FOR MALE RATS Animal NORM SM DB PC GP BP TOX VC SPEC Number Male, Group: 1-0 ing/kg - Day 123 641083 NORMAL ,, -,, - -- - 641084 NORMAL -- -- -- -- -- -- -- 641085 NORMAL -- -- -- -- -- -- -- 641101 NORMAL -- -- -- -- -- -- -- 641105 NORMAL -- -- -- -- -- -- -- 664411112534 NORMAL -- -- - 1 -- -- -- -- ADEQ PLATEL -- -- -- 641159 -- -- -- 1 DECR PLATEL 641165 -- -- -- 1 ADEQ PLATEL 641215 NORMAL -- -- -- -- -- ,-.- -- Male, Group: VII - 1000 mg/kg - Day 123 641064 - 1 DECR PLATEL 641092 NORMAL -- -- -- -- -- -- -- 641143 641153 NORMAL NORMAL -- -- -- -- -- -- -- 641167 -- -- -- -- . -- --- --1 --- --- --- 641185 NORMAL -- -- -- -- -- -- -- 641189 NORMAL ,,,, - - - -- -- -- 641203 -- -- -- -- 1 -- -- -- 641213 NORMAL -- -- -- -- -- -- -- 641216 NORMAL -- -- -- -- -- -- -- 699 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL WHITE BLOOD CELL / PLATELET MORPHOLOGY VALUES FOR FEMALE RATS Animal NORM SM DB PC GP BP TOX VC SPEC Number Female, Group: 11-0 nig/kg - Day 44 jle 641240 NORMAL . -- - S 641245 -- -- -- 1 641249 NORMAL DECR PLATEL 99 641257 - - 1 -- -- - -- ADEQ PLATEL sii 641283 -- NORMAL --- --- -- -- -- -- -- sss 641290 -- -- -- 1 ADEQ PLATEL 3; 641293 NORMAL -- -- -- -- -- -- -- 641335 1 ADEQ PLATEL 641344 NORMA--L --- --- -- -- -- -- -- 641384 -- -- -- 1 DECR PLATEL 0 Female, Group: IV - 50 mg/kg - Day 44 1 3 641260 --' -- -- 1 ADEQ PLATEL s. 641298 NORMAL -- -- -- -- -- -- -- S 0 641311 -- -- -- 1 ADEQ PLATEL 641312 NORMAL -- -- -- -- -- -- -- 641313 NORMAL -- . -- -- -- -- -- -- 5" 641336 NORMAL -- -- -- -- -- -- -- -j 641355 NORMAL -- -- -- -- -- -- -- 641361 NORMAL 9 641369 NORMAL ~ .- -- ~-~ > 0 641396 NORMAL --- --- --- --- --- --- --- IS 700 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUA:L WHITE BLOOD CELL / PLATELET MORPHOLOGY VALUES FOR FEMALE RATS Animal NORM SM DB PC GP BP TOX VC SPEC Number Female, Group: VI - 250 mg/kg - Day 44 641244 NORMAL 1 641251 641269 NORMAL NORMAL -- -- ,, -- -- -- s? 641292 -- AL - -- 1 ,,,, ,,.- -- -- DECK PLATEL a o 641302 641362 NORM -- -- --1 -- -- -- -- DECR PLATEL 641363 -- -- 1 DECR PLATEL 641375 -- -- -- 1 ADEQ PLATEL o 641379 NORMA--L -- -- 641398 -- --- -- 1 -': " -- Female, Group: VIII - 1000 mg/kg - Day 44 a. 0 641237 NORMAL- -- -- -- -- -- -- -- 641275 NORMAL .-- -- -- -- -- -- -- ! 641279 NORMAL - 641299 NORMAL -- -- -- -- -- -- 664411331040 NORMAL -- 1 DECR PLATEL 641326 8 641327 -- 11 DECR PLATEL DECR PLATEL a ^ 641380 NORMAL -- -- -- -- -- - -- 641390 NORMAL " " " $ 0 ra 701 [-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDXVIDUA.L WHITE BLOOD CELL / PLATELET MORPHOLOGY VALUES FOR FEMALE RATS Animal NORM SM DB PC GP BP TOX VC SPEC Number Female, Group; II-O mg/kg - Day 92 641240 641245 NORMAL -- 1 . 0 641249 -- - - ,,- 1 - 1 -- -- ADEQ PLATEL S 641257 -- -- -- 1 ADEQ PLATEL S 641283 NORM-A-L -- -- S 5 641290 NORMAL --- -- -- - -- -- -- -- - -- 641293 NORMAL ,, w 641335 NORMAL -- - - 5 641344 -- -- --1 -- ,, -- -- -- -- -- ADEQ PLATEL sM 6413S4 NORMAL -- -- -- -- -- -- -- <s a. Female, Group: IV - 50 ing/kg - Day 92 1 0 641260 NORMAL" . ,,,, ,,,,. . ffi 641298 NORMAL -- -- -- -- -- -- -- 3 a 641311 NORMAL - 641312 -- --1 -- -- -- -- DECR PLATEL a 641313 --- --- --- 1 DECR PLATEL 0 641336 NORMAL -- -- -- -- -- -- -- 641355 -- -- -- 1 ADEQ PLATEL 3" 641361 NORMAL -- -- -- -- -- -- -- 3 641369 641396 NORMAL -- -- --1 -- -- -- -- ADEQ PLATEL 8 - -~ > 0 GO 702 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations i'''S? s & 3 to EB I" a 0 0 0 (0 3 <2,? 0 3 . 5' -1 t 0 > 0 (S INDIVIDUAL WHITE BLOOD CELL / PLATELET M(3RPHOLOBY VALUES FOR FEMALE RATS Animal NORM SM DB PC GP BP TOX VC SPEC Number Female/ Group! VI - 250 ing/kg - Day 92 641244 NORMAL ,,,, -- ,, -- 641251 NORMAL -- -- - - -- --, -- 641269 641292 -- -- -- 1 1 DECR PLATEL 641302 NORMA--L -- -. -- -- -,- 641362 NORMAL -- -- - - - -- -- - ~ 641363 641375 NORMAL -- -- -- ,, 1 -- -- 641379 -- NORMAL -- -- ,, -- ,, 641398 NORMAL -- -- -- - ,,-. - -- -- -- -- -- ,,- -- Female/ Group: VIII - 1000 mg/kg - Day 92 641237 --. -- -- 1 DECR PLATEL 641275 641279 NORMAL -- -- -- --1 -- -- -- 641299 NORMA--L -- -- -- -- -- -- 641300 NORMAL -- -- -- ,,,, - - ,,- 641314 NORMAL -- -- -- .... - ,, 641326 NORMAL --- --- --- --- --- --- --- 641327 NORMAL -- -- -- -- -- -- -- 641380 641390 NORMAL NORMAL -- -- -- -- -- -- -- -- -- -- -- -- -- -- 703 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUA:L WHITE BLOOD CELL / PLATELET :MORPHOLOGY VALUES FOR FEMALE RATS Animal MORM SM DB PC GP BP TOX VC SPEC Number Female, Group: XI - 0 mg/kg - Oay 124 641253 NORMAL - -.. ,, ,, - J' 641266 -- -- -- 1 1 ADEQ PLATEL 641281 641294 -- -- -- 1 1 ADEQ PLATEL 641325 NORMA- -L -- -- -- -- -- -- 641331 NORMAL -- -- -- -- -- -- 641359 NORMAL -- -- -- ,- -- -- -- 641364 -- ' -- -- --1 .1- -- -- - ADEQ PLATEL 1 S3? 641383 641400 NORMA--L -- -- -- -- -- -- IS" ^ ,,. ,, ,, --. VIII a P- Female, Group: - 1000 mg/kg - Day 124 .. 641234 a 0 - ,, ,, ,, 1 ,, . (9 (B 641256 641282 -- -- -- -- 1 -- -- -- 3 0 641352 NORMA--L -- - 1 -- ,- tBSa 0 641356 -- -- - ,, 641366 NORMAL -- -- -- -- -- -- -- 5' 3" 641377 641385 NORMAL NORMAL -- -- -- -- -- -- -- 3 641387 NORMAL -- -- -- -- -- -- -- -- - -- -- ,, -- ,, 8 641399 -- -- -- -- 1 -- -- -- > 0 ra 704 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL COAGULATION VALUES FOR MALE RATS Animal Number PHEM FLIP PICT Male, Group: I - 0 mg,/kg - Day 91 641069 641070 641094 641147 641149 641155 641172 641206 641214 641222 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NOME NONE NONE NONE NONE NONE NONE NONE NONE NOME NOME Male, Group: 641055 641056 641073 641081 641144 641146 641178 641198 641218 641224 III - 50 ing/kg - Day 91 NOMENONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NOME NOME NONE NOME NOME NOME MOME NONE NOME NONE NONE NOME NOME NOME NOME NONE NOME NOME NONE P T se c 15. 1 15. 2 14. 5 15. 3 16. 0 15. 4 14. 9 15. 3 14. 6 15. 0 15. 1 14. 8 14.4 15. 6 15. 6 15. 0 15. 3 15. 7 14. 8 14. 5 AP'TT S-ec 19 .7 20 .6 20 .0 16 .7 30 .1 20 .1 16 .7 18 .8 18 .5 19 .4 22 .0 21 .2 18 .2 17 .1 20 .0 27 .2 19 .3 18 .1 17 .2 18 .3 705 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL COAGULATION VALUES FOR MALE RATS Animal Number PHEM FLIP PICT Male, Group: V - 250 mg/'kg - Day 91 641061 641089 641102 641134 641137 641162 641190 641197 641200 641202 NOME NONE NONE NONE NONE NONE CLOT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NOME NONE NONE NONE NONE NONE NONE NONE NONE NT NOME NONE NONE Male, Group: VII - 1000 nig/kg - Day 91 641067 641077 641086 641095 641097 641132 641157 641166 641201 641223 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NOME NONE NONE NONE NONE NONE NONE NONE NONE NONE PT s ec 16 .2 15 .9 15 .3 14 .9 16 .9 15 .5 NT 16 .6 15 .4 15 .0 15 .7 15 .5 16 .0 14 .8 15 .0 15.7 15 .9 16 .9 16 .1 15 .2 APTT s ec 21 .0 17.4 19 .5 20 .5 17 .9 19 .3 NT 22 .9 21 .0 19 .1 15 .3 18 .2 20 .7 22 .6 16 .8 16 .5 20 .4 20 .2 21 .7 22 .3 706 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL COAGULATION VALUES FOR FEMALE RATS Animal Number PHEM FLIP PICT Female, Group: 641240 641245 641249 641257 641283 641290 641293 641335 641344 641384 II - 0 NONE NONE NSR NONE NONE NONE NONE NOME NONE NONE I ng/kg - Day S)2 NOME MOME MT NONE MOME MOME NONE MOME MOME NONE MOME NONE NT NOME MOME NONE NONE NOME MOME NONE Female, Group: IV - 50 mg/kg - Day 92 641260 641298 641311 641312 641313 641336 641355 641361 641369 641396 NONE NONE NOME NOME NONE NONE MOME MOME NONE MOME NONE NONE NONE NONE NONE MOME MOME NONE MOME MOME MONE NONE MONE MONE NONE NONE MONE NONE NONE MOME PT s ec 15 .1 15 .2 NT 15 ,5 15 .2 14 .9 15 .8 15 .1 15 .9 15 .2 14 .8 15 .3 14 .7 15 .6 16 .3 15 .6 14 .9 13 .9 15 .9 15 .0 AFTT s ec 18 .6 19 .2 MT 18 .4 19 .0 19 .6 20 .7 22 .0 20 .3 20 .7 17.4 18 .2 23 .1 21 .8 19 .2 17 .7 20 .7 18 .9 20 .4 18 .2 707 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL COAGULATION VALUES FOR FEMALE RATS Animal Number PHEM FLIP PICT Female, Group: VI - 250 nig/kg - Day 92 641244 641251 641269 641292 641302 641362 641363 641375 641379 641398 NOME NONE NONE NONE NONE NOME NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Female, Group: VIII - 641237 641275 641279 641299 641300 641314 641326 641327 641380 641390 NONE NONE NONE NONE NONE NONE NOME NONE NONE NONE 1000 ing/kg - NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Day 92 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE PT sec 15 .4 16 .0 15 .3 15 .3 16 .3 15 .2 13 .9 14 .5 14 .3 15 .6 15.4 15 .3 14 .8 15 .8 15 .6 15 .1 15.1 14 .3 15 .9 14 .6 APTT sec 17.3 16.9 18.2 19.5 17.4 19.5 20.3 17.4 17.9 18.4 20.2 16.4 16.7 19.2 17.8 16.8 20.2 17.6 18.3 20.0 708 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS Animal Number SHEM SLIP SICT Male, Group: 641069 641070 641094 641147 641149 641155 641172 641206 641214 641222 1-0 ing/kg - TRACE TRACE SMALL NONE NONE TRACE TRACE SMALL SMALL NONE Day 44 NONE NONE NOME NOME NOME NOME NOME NOME NONE NOME NONE NONE NOME NONE NONE NOME MOME MONE NONE MOME Male, Group: 641055 641056 641073 641081 641144 641146 641178 641198 641218 641224 III - 50 nig/kg - Day 44 NONESMALL SMALL NONE SMALL SMALL NONE NONE SMALL NONE NOME NOME MOME NOME NOME NONE MOME MOME MOME NONE MONE NOME MONE MOME MONE NONE MOME MOME MONE MOME AST IU/L 105 81 91 67 87 114 85 75 119 81 72 88 88 65 86 71 79 99 132 83 ALT IU/L 33 48 40 24 37 39 39 35 43 39 36 51 34 30 41 29 37 .44 47 36 SDH IU/L 18.6 19.9 16.2 17.8 20.0 23.3 19.4 20.2 19.9 29.0 23.6 26.5 21.3 16.9 25.7 22.0 20.1 28.1 18.5 39.4 ALKP IU/L BILI mg/dL BUM mg/dL 112 0.16 17 103 <0.10 14 152 <0.10 15 122 <0.10 12 125 0.11 15 138 <0.10 17 156 0.11 15 127 0.11 18 115 <0.10 14 121 0.14 14 99 0.11 12 121 <0.10 15 168 <0.10 19 111 <0.10 15 141 <0.10 16 143 <0.10 13 116 0.11 14 159 <0.10 14 102 0.12 15 136 <0.10 14 709 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AMD PLASMA CHEMISTRY VALUES FOR MALE RATS Animal Number SHEM SLIP SICT Male, Group: V - 250 ing/kg - Day 44 641061 641089 641102 641134 641137 641162 641190 641197 641200 641202 NONE SMALL TRACE TRACE NONE TRACE SMALL TRACE MODE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: VII - 1000 nig/kg - Day 44 641067 641077 641086 641095 641097 641132 641157 641166 641201 641223 SMALL. TRACE SMALL SMALL TRACE SMALL SMALL NOME SMALL NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE . NONE NONE NONE NONE NONE NONE NONE NONE AST IU/L 72 77 65 81 87 81 89 108 106 84 104 91 88 78 77 80 84 110 90 81 ALT IU/L 32 33 35 39 55 34 33 36 38 30 53 42 42 41 35 35 37 68 37 45 SDH IU/L 24.6 23.4 14.1 24.8 25.2 24.0 26.4 29.4 29.3 16.1 19.8 19.1 20.4 22.3 21.0 23.1 13.6 28.0 18.6 19.4 ALKP IU/L BILI mg/dL BUN mg/dL 94 <0.10 19 119 <0.10 15 119 <0.10 11 142 0.10 17 106 <0.10 19 92 <0.10 17 153 <0.10 14 112 <0.10 14 102 0.11 13 110 <0.10 15 156 0.10 19 115 0.11 14 146 <0.10 14 138 <0.10 16 131 <0.10 15 206 <0.10 17 142 <0.10 18 209 <0.10 15 160 <0.10 18 180 <0.10 14 710 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS Animal Number TRIG ing/dL GLUC mg/dL TP g/dL Male, Group: 1-0 ing/kg - Day 44 641069 105 105 6.8 641070 116 105 7.0 641094 67 113 6.5 641147 38 97 6.5 641149 72 101 6.4 641155 51 101 6.7 641172 94 114 7.0 641206 41 108 6.8 641214 59 93 6.5 641222 105 101 7.1 Male, Group: III - 50 ing/kg - Day 44 641055 85" 107 6.8 641056 81 109 6.7 641073 101 99 6.6 641081 34 103 6.6 641144 140 114 6.9 641146 36 ioi 6.8 641178 84 94 6.7 641198 99 102 7.1 641218 42 101 6.8 641224 184 106 6.6 ALB g/dL 4.3 4.3 4.4 4.1 4.1 4.1 4.2 4.2 4.2 4.4 4.2 4.1 4.4 4.1 4.4 4.2 4.1 4.4 4.4 4.3 GLOB g/dL CALC mg/dL IPHS mg/dL NA mnol/L K mrnol/L 2.5 10.6 2.7 11.2 2.1 10.3 2.4 10.3 2.3 10.8 2.6 10.8 2.8 10.9 2.6 10.4 2.3 10.7 2.7 11.1 2.6 10.7 2.6 10.3 2.2 11.0 2.5 11.0 2.5 10.7 2.6 10.8 2.6 10.8 2.7 11.3 2.4 10.4 2.3 11.1 8.7 144.3 8.8 149.1 8.1 147.9 8.1 147.7 9.1 149.9 8.6 147.7 7.9 147.1 7.9 149.8 9.2 148.4 9.6 147.9 9.3 147.6 9.0 148.1 9.1 148.8 7.8 148.1 8.4 148.0 8.7 149.0 8.7 147.8 9.5 149.6 8.6 146.4 8.1 147.2 6.71 7.10 6.31 6.14 6.14 6.21 6.01 6.55 6.86 6.50 6.39 6.13 6.57 6.29 6.41 6.06 6.16 6.48 6.08 6.31 711 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AMD PLASMA CHEMISTRY VALUES FOR MALE RATS Animal Number TRIG mg/dL GLUC mg/dL TP g/dL Male, Group; V - 250 nig/kg - Day 44 641061 72 98 6.9 641089 38 103 5.8 641102 40 109 6.7 641134 29 99 6.3 641137 61 104 6.3 641162 46 97 6.3 641190 43 94 6.3 641197 27 88 6.1 641200 168 107 6.8 641202 49 96 6.3 Male, Group: VII - 1000 mg/kg - Day 44 641067 641077 641086 641095 641097 641132 641157 641166 641201 641223 29- 104 6.6 14 101 7.1 40 106 6.7 55 103 7.1 96 127 6.6 43 122 7.1 25 107 6.3 39 96 7.0 30 105 6.4 44 116 6.6 ALB g/dL 4.3 3.8 4.4 4.4 4.2 4.4 3.9 4.2 4.4 4.3 4.4 4.7 4.5 4.9 4.5 4.8 4.3 4.8 4.2 4.6 GLOB g/dL CALC mg/dL IPHS mg/dL NA inmol/L K inmol/L 2.6 11.4 9.1 148.9 6.63 2.0 10.4 9.3 147.8 6.48 2.3 10.5 7.9 148.2 6.14 1.9 10.8 9.0 148.4 6.44 2.1 10.4 7.8 147.3 5.86 1.9 11.1 10.0 149.6 6.37 2.4 10.9 9.3 148.7 6.16 1.9 10.2 9.0 149.3 6.35 2.4 11.1 8.7 148.3 6.55 2.0 10.5 9.0 148.6 6.16 2.2 10.6 2.4 10.8 2.2 10.5 9.7 147.6 8.6 147.3 9.1 148.1 6.91 6.10 6.42 2.2 10.7 8.9 146.8 6.17 2.1 10.8 9.8 148.9 7.24 2.3 11.2 10.0 147.8 6.86 2.0 10.6 9.0 147.2 5.99 2.2 11.0 8.6 148.6 6.63 2.2 10.5 8.9 147.2 6.14 2.0 10.6 8.7 148.2 6.93 712 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS Animal Number PLIP PICT PFLU Male, Group: 1-0 mg/kg - - Day 44 641069 NT NT MT 641070 NT NT NT 641094 NT NT NT 641147 NT NT NT 641149 NT NT NT 641155 NT NT NT 641172 NT NT NT 641206 NT NT NT 641214 NT NT NT 641222 NT NT NT Male, Group: III - 50 g/kg - Day 44 641055 NT- NT NT 641056 NT NT NT 641073 NT NT NT 641081 NT NT NT 641144 NT NT NT 641146 NT NT NT 641178 NT NT NT 641198 NT NT NT 641218 NT NT NT 641224 NT NT NT 713 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS Animal Number PLIP PICT PFLU Male, Group: V - 250 ing/kg - Day 44 641061 NT NT NT 641089 NT NT NT 641102 NT NT NT 641134 NT NT NT 641137 NT NT NT 641162 NT NT NT 641190 NT NT NT 641197 NT NT NT 641200 NT NT NT 641202 NT NT NT Male, Group: VII - 1000 ing/kg - Day 44 641067 NT NT NT 641077 MT NT NT 641086 NT NT NT 641095 NT NT NT 641097 NT NT NT 641132 NT NT NT 641157 NT NT NT 641166 NT NT NT 641201 NT NT NT 641223 NT NT NT 714 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS Animal Number SHEM SLIP SICT Male, Group: 641069 641070 641094 641147 641149 641155 641172 641206 641214 641222 1-0 ing/kg - NONE TRACE NONE NONE NONE NONE TRACE TRACE NONE NONE Day 91 NONE NONE NONE NONE NONE NONE NONE NONE NOME NONE NONE NONE NONE NONE NONE NONE NONE NONE NOME NONE Male, Group: 641055 641056 641073 641081 641144 641146 641178 641198 641218 641224 III - 50 ing/kg - Day 91 NONE TRACE TRACE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE . NONE NONE NONE NONE NONE NONE NONE NONE AST IU/L 94 74 81 66 96 96 83 84 86 84 78 129 84 83 72 78 79 134 93 90 ALT IU/L 37 36 44 23 36 37 37 33 31 38 34 63 30 40 47 30 35 83 52 42 SDH IU/L 31.2 20.0 20.8 20.1 21.8 21.9 22.7 17.6 22.0 35.8 21.6 27.2 26.9 22.2 26.0 20.3 20.7 44.6 21.9 39.9 ALKP IU/L BILI mg/dL BUN mg/dL 70 0.14 15 60 0.12 16 109 0.15 14 73 0.14 16 79 0.16 13 87 0.15 17 83 0.12 16 89 0.15 15 72 0.14 13 78 0.15 16 77 <0.10 14 82 0.15 17 123 0.11 16 149 0.14 18 90 0.12 17 109 0.12 14 101 0.15 19 106 0.20 14 69 0.20 16 94 0.13 15 715 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS Animal Number SHEM SLIP SICT Male, Group: V - 250 ing/kg - Day 91 641061 641089 641102 641134 641137 641162 641190 641197 641200 641202 NONE NONE NOME NONE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NOME NONE NONE NONE NONE NONE NONE NONE NOME NOME MONE NONE NOME NOME Male, Group: VII - 1000 mg/kg - Day 91 641067 641077 641086 641095 641097 641132 641157 641166 641201 641223 NONE NONE TRACE TRACE TRACE TRACE TRACE TRACE TRACE NONE NOME NONE NONE NOME NOME NONE NONE NONE NOME NOME NOME MONE NONE NOME MONE MONE NOME NOME NOME MONE AST IU/L 91 77 66 150 74 65 112 108 98 73 113 92 88 100 82 84 90 128 91 67 ALT IU/L 32 35 39 115 37 36 73 54 47 35 51 40 55 58 39 47 55 56 37 37 SDH IU/L 23.5 18.0 15.7 41.8 21.3 20.2 24.7 25.1 27.3 22.8 18.6 19.0 20.9 31.8 18.5 24.8 22.1 27.1 21.4 19.3 ALKP IU/L BILI mg/dL BUM mg/dL 93 <0.10 20 98 <0.10 19 108 0.13 15 146 0.17 20 100 0.14 22 77 0.16 18 162 0.12 20 114 0.14 16 115 0.10 18 91 0.13 17 177 0.11 22 130 0.14 14 180 0.10 18 202 0.11 21 157 0.12 19 223 0.14 17 192 0.15 22 179 0.10 18 168 0.10 19 217 0.13 19 716 w H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS Animal Number TRIG mg/dL GLUC mg/dL TP g/dL Male, Group: 1-0 mg/kg - Day 91 641069 109 117 7.0 641070 93 109 7.0 641094 139 120 7.3 641147 53 105 7.1 641149 52 105 7.0 641155 53 109 7.2 641172 85 117 7.4 641206 95 118 7.2 641214 54 118 7.3 641222 80 110 7.7 Male, Group; III - 50 ing/kg - Day 91 641055 77. 109 7.3 641056 92 110 6.8 641073 84 111 7.2 641081 164 153 7.2 641144 174 119 7.3 641146 82 113 6.9 641178 67 122 7.5 641198 71 119 7.4 641218 64 108 7.0 641224 150 115 7.2 ALB g/dL 4.2 4.0 4.7 4.2 4.2 4.1 4.1 4.2 4.4 4.6 4.2 4.1 4.6 4.0 4.2 4.1 4.4 4.3 4.3 4.6 GLOB g/dL CALC mg/dL IPHS NA K mg/dL mmol/L inmol/L m 2.8 10.5 3.0 10.6 2.6 10.9 2.9 10.8 2.8 10.5 3.1 10.8 3.3 10.9 3.0 10.4 2.9 11.0 3.1 10.9 3.1 10.4 2.7 10.4 2.6 10.7 3.2 11.2 3.1 10.4 2.8 10.3 3.1 10.9 3.1 10.9 2.7 10.4 2.6 10.9 7.4 145.4 7.3 147.2 7.4 146.1 7.2 146.9 7.6 145.9 7.3 145.9 7.1 146.6 7.3 148.3 7.7 147.5 7.8 145.6 7.8 148.7 7.7 145.7 6.8 146.9 6.6 146.1 6.7 145.9 7.1 146.1 7.7 146.0 7.8 146.9 7.2 146.1 6.8 147.3 6.19 6.50 6.66 5.99 6.23 5.96 5.90 5.90 6.24 6.90 6.28 5.76 5.96 6.36 5.72 5.46 6.24 5.91 5.72 6.32 717 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AMD PLASMA CHEMISTRY VALUES FOR MALE RATS Animal Number TRIG ing/dL GLUC mg/dL TP g/dL Male, Group: V - 250 nig/kg - Day 91 641061 98 121 7.8 641089 82 127 6.8 641102 87 116 7.5 641134 36 104 7.0 641137 63 113 7.5 641162 79 123 7.3 641190 44 114 7.1 641197 47 113 6.5 641200 110 117 7.6 641202 59 120 7.0 Male, Group: VII - 1000 mg/kg - Day 91 641067 641077 641086 641095 641097 641132 641157 641166 641201 641223 37" 126 6.8 37 114 7.4 35 115 7.0 36 130 6.8 61 117 7.1 61 137 7.4 32 122 6.6 41 114 7.6 45 115 6.8 57 122 7.2 ALB g/dL 4.6 4.3 4.7 4.6 4.5 4.7 4.4 4.3 4.8 4.6 4.4 4.7 4.6 4.7 5.0 4.9 4.4 5.1 4.5 4.9 GLOB g/dL CALC mg/dL IPHS mg/dL NA nrool/L K mmol/L 3.2 11.4 2.5 10.6 2.8 10.8 2.4 10.7 3.0 11.0 2.6 11.1 2.7 11.0 2.2 10.2 2.8 10.9 2.4 10.5 8.9 148.9 7.2 146.3 7.3 146.9 7.8 147.8 7.3 146.7 7.4 147.6 8.2 145.7 7.8 147.0 7.2 148.7 7.7 147.3 6.39 5.63 6.21 6.02 6.27 6.15 6.23 6.39 5.85 5.54 2.4 10.1 7.5 145.2 5.64 2.7 10.5 7.2 144.9 5.78 2.4 10.0 7.7 147.7 5.88 2.1 10.5 10.1 142.4 7.26 2.1 10.4 7.2 145.3 6.20 2.5 10.5 2.2 10.1 7.8 145.8 7.6 145.5 6.16 5.95 2.5 10.6 7.0 146.7 6.27 2.3 10.1 2.3 10.5 6.9 146.8 7.5 144.0 6.00 6'. 3 6 718 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SEROM AND PLASMA CHEMISTRY VALUES FOR MALE RATS Animal Number FLIP PICT PF:LU (ig/inL Male, Group: I - 0 ing/kg - - Day 91 641069 NONE NONE 0 .1 641070 NONE NONE 0 .1 641094 NONE NONE 0 .1 641147 NONE NONE 0 .1 641149 NONE NONE 0 .1 641155 NONE NONE 0 .1 641172 NONE NONE 0 .1 641206 NONE NONE 0 .1 641214 NOME NONE 0 .1 641222 NONE NONE 0 .1 Male, Group: III - 50 ing/kg - Day 91 641055 NONE- NONE 0 .1 641056 NONE NONE 0 .1 641073 NONE NONE 0 .1 641081 NONE NONE 0 .1 641144 NONE NONE 0 .1 641146 NONE NONE 0 .1 641178 NONE NONE QNS 641198 NONE NONE 0 .1 641218 NONE NONE 0 .1 641224 NONE NOME 0 .1 719 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AMD PLASMA CHEMISTRY VALUES FOR MALE RATS Animal Number PLIP PICT PPLU lig/vS-i Male, Group: V - 250 ing/kg - Day 91 641061 NOME NONE 0.1 641089 NONE NOME 0.1 641102 NONE NONE 0.1 641134 NONE NONE QNS 641137 NONE NONE 0.1 641162 NONE NONE 0.1 641190 NONE NONE 0.1 641197 NONE NONE 0.1 641200 NONE NONE QNS 641202 NOME NONE 0.1 Male, Group: VII - 1000 ing/kg - Day 91 641067 NONE" NONE 0.1 641077 NONE NONE 0.1 641086 NONE NOME 0.1 641095 NONE NOME 0.1 641097 NONE NONE 0.1 641132 NONE NOME 0.1 641157 NONE NONE 0.1 641166 NONE NONE 0.1 641201 NONE NONE 0.1 641223 NONE NONE 0.1 720 A A ^::^:: ::<s$3 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS Animal Number SHEM SLIP SICT Male/ Group: 641083 641084 641085 641101 641105 641123 641154 641159 641165 641215 1-0 nig/kg -- NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Day 123 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NOME NONE NONE NONE NONE Male, Group: VII - 1000 ing/kg - Day 123 641064 641092 641143 641153 641167 641185 641189 641203 641213 641216 NONENOME NONE TRACE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NOME NONE NOME NONE NONE NONE NONE NONE AST IU/L 82 69 84 80 75 74 106 73 75 74 117 67 71 90 155 85 95 453 93 79 ALT IU/L SDH IU/L 34 20.6 27 15.2 32 18.8 34 21.8 33 18.7 32 14.7 40 23.1 30 22.6 29 14.0 53 24.9 48 18.6 36 15.5 40 18.9 54 19.7 RNV 45.0 45 21.5 65 18.1 520 133.0 41 20.4 37 16.4 ALKP IU/L BILI mg/dL BUN mg/dL 66 0.12 16 66. <0.10 16 84 0.10 15 73 0.12 12 83 <0.10 14 85 <0.10 13 61 0.10 14 78 <0.10 14 103 <0.10 12 103 0.12 13 114 <0.10 18 115 <0.10 15 83 <0.10 16 160 <0.10 18 161 <0.10 13 144 <0.10 17 136 <0.10 14 215 0.11 12 105 <0.10 12 116 <0.10 15 721 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations TNDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS Animal Number TRIG mg/dL GLUC mg/dL TP g/dL Male, Group: 1-0 ing/kg - Day 123 641083 180 118 7.2 641084 245 126 7.0 641085 120 112 7.1 641101 283 137 7.0 641105 157 110 7.0 641123 213 131 6.7 641154 169 112 6.4 641159 269 131 6.9 641165 157 111 6.8 641215 302 133 7.2 Male, Group: VII - 1000 ing/kg - Day 123 641064 110 113 7.0 641092 180 122 7.0 641143 92 114 7.0 641153 42 130 6.3 641167 153 135 7.3 641185 78 111 7.1 641189 71 124 6.9 641203 79 123 7.3 641213 209 131 7.4 641216 .137 116 6.8 ALB g/dL 4.3 4.3 4.2 4.3 4.1 4.0 4.2 4.2 4.0 4.4 4.6 4.5 4.5 4.2 4.6 4.7 4.4 4.6 4.9 4.3 GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L K mmol/L 2.9 11.3 2.7 10.7 2.9 11.3 2.7 11.3 2.9 10.8 2.7 11.1 2.2 10.8 2.7 11.0 2.8 10.8 2.8 11.5 2.4 10.8 2.5 11.3 2.5 10.8 2.1 10.4 2.7 11.1 2.4 10.9 2.5 10.6 2.7 11.1 2.5 11.3 2.5 11.3 7.3 145.6 6.8 145.0 7.0 146.7 7.2 147.2 7.3 146.1 7.0 147.3 6.5 145.4 7.4 146.1 6.6 147.6 6.9 147.7 8.2 146.2 7.3 146.9 7.0 148.9 7.8 147.5 7.2 146.6 7.9 146.7 7.2 146.7 7.6 146.3 7.2 146.1 8.0 147.9 5.93 5.83 5.85 6.54 6.23 6.17 5.92 6.29 5.81 5.96 6.47 6.64 5.93 6.31 6.07 6.51 5.91 6.12 6.10 5.79 722 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR MALE RATS Animal Number PLIP PICT PFLU Male, Group: 1-0 mg/kg - Day 123 641083 MT NT MT 641084 MT NT NT 641085 NT NT NT 641101 NT NT NT 641105 NT NT NT 641123 MT NT MT 641154 NT NT NT 641159 NT NT NT 641165 NT MT MT 641215 NT NT NT Male, Group: VII - 1000 mg/kg - Day 123 641064 NT NT NT 641092 NT NT MT 641143 NT NT NT 641153 NT NT MT 641167 NT NT MT 641185 NT NT NT 641189 NT MT MT 641203 NT NT NT 641213 NT NT NT 641216 NT NT NT 723 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AMD PLASMA CHEMISTRY VALUES FOR FEMALE RATS Animal Number SHEM SLIP SICT AST IU/L ALT IU/L Female, Group: 641240 641245 641249 641257 641283 641290 641293 641335 641344 641384 II - 0 SMALL SMALL TRACE NONE SMALL TRACE NONE NONE SMALL SMALL ing/kg - Day 44 NONE NONE NONE NONE NONE NONE NONE NOME NONE NONE NONE NONE NONE NONE NONE NONE NONE NOME NONE NONE Female, Group: IV - 50 mg/kg - Day 44 641260 641298 641311 641312 641313 641336 641355 641361 641369 641396 SMALL SMALL NONE MODERATE NONE SMALL NOME TRACE TRACE SMALL NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 83 95 74 90 79 89 79 80 78 73 106 79 82 MT-HEMOL 77 214 94 80 152 82 38 37 33 35 33 36 40 35 36 30 35 30 35 NT-HEMOL 28 104 44 36 95 35 SDH IU/L ALKP IU/L BILI mg/dL BUN ing/dL 20.5 60 0.13 13 15.1 125 0.14 13 23.2 82 <0.10 14 37.1 118 0.15 17 21.0 66 0.11 15 17.9 58 0.12 15 25.8 93 0.12 17 20.8 92 0.10 17 19.8 56 0.15 21 23.1 64 0.10 14 12.7 90 0.11 13 22.2 91 0.10 16 21.1 112 0.11 16 14.6 NT-HEMOL NT-HEMOL 15 18.8 71 0.12 14 57.4 105 0.10 15 17.3 81 0.15 16 21.2 107 <0.10 15 32.4 77 <0.10 18 23.6 85 <0.10 17 724 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR FEMALE RATS Animal Number SHEM SLIP SICT Female, Group: VI - 250 mg/kg - Day 44 641244 641251 641269 641292 641302 641362 641363 641375 641379 641398 NONE TRACE NONE SMALL NOME SMALL NONE SMALL SMALL SMALL NONE NONE NONE NONE NONE NONE NONE NONE NOME NONE MONE NONE NONE NONE NONE NOME NOME MOME MONE NONE Female, Group: VIII - 641237 641275 641279 641299 641300 641314 641326 641327 641380 641390 MONETRACE SMALL SMALL TRACE TRACE TRACE SMALL SMALL SMALL 1000 mg/kg - NONE NOME NONE NONE NONE NOME NOME MOME NOME NOME Day 44 NONE NOME MOME MONE NONE NOME NOME NOME NOME MOME AST IU/L 68 76 85 82 86 80 87 83 87 83 100 92 75 94 135 82 74 62 100 99 ALT IU/L 27 39 38 32 34 32 34 35 43 41 40 36 24 40 41 40 35 31 47 59 SDH IU/L 19.1 20.2 23.1 9.7 24.7 19.2 14.0 12.2 21.5 22.5 22.8 25.3 20.5 20.4 12.4 16.8 18.3 15.2 17.4 34.2 ALKP IU/L BILI mg/dL BUM mg/dL 72 <0.10 15 113' <0.10 14 95 0.11 18 70 <0.10 16 98 0.13 17 81 0.15 17 68 <0.10 12 56 0.10 13 90 <0.10 20 68 0.10 16 66 <0.10 18 82 0.12 18 58 0.11 15 81 <0.10 15 103 <0.10 13 112 <0.10 16 78 <0.10 18 80 <0.10 19 104 <0.10 21 54 <0.10 16 725 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AMD PLASMA CHEMISTRY VALUES FOR FEMALE RATS Animal Number TRIG mg/dL GLUC mg/dL TP g/dL ALB g/dL GLOB g/dL Female, Group: II - 0 mg/kg - Day 44 641240 641245 641249 641257 641283 641290 641293 641335 641344 641384 53 104 7.6 61 79 7.3 25 113 7.2 52 89 7.5 50 102 7.0 54 111 7.9 55 98 7.5 39 83 7.5 33 104 7.3 39 88 7.2 Female, Group: IV - 50 nig/kg - Day 44 641260 641298 641311 641312 641313 641336 641355 641361 641369 641396 31. 30 27 NT-HEMOL 18 58 69 31 43 40 96 6.8 95 7.4 95 7.9 113 NT-HEMOL 95 6.3 103 7.7 87 7.4 101 7.1 85 7.2 115 7.2 5.0 4.8 4.9 5.0 4.7 5.4 4.9 5.0 4.9 5.0 4.8 4.9 5.1 NT-HEMOL 4.3 5.4 5.1 4.8 5.1 4.9 2.6 2.5 2.3 2.5 2.3 2.5 2.6 2.5 2.4 2.2 2.0 2.5 2.8 NT-HEMOL 2.0 2.3 2.3 2.3 2.1 2.3 CALC mg/dL IPHS mg/dL NA mmol/L K nrool/L 11.1 10.5 11.2 11.4 10.6 11.2 11.2 11.0 10.9 10.9 7.9 144.9 7.2 144.7 8.4 145.9 9.3 149.0 7.6 147.3 7.8 144.3 8.4 147.9 8.0 147.1 7.3 144.8 8.1 145.6 6.64 5.64 5.97 6.75 5.97 6.03 6.77 6.30 6.10 6.37 10.5 7.2 146.7 5.69 10.9 8.6 146.5 6.46 11.2 8.9 144.6 5.90 10.5 MT-HEMOL NT-HEMOL MT-HEMOL MT 10.2 8.1 146.9 5.51 10.8 6.5 144.0 6.01 10.9 7.8 145.4 5.81 10.6 7.8 147.9 6.23 11.2 8.1 146.2 6.51 10.6 7.0 147.9 5.93 726 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR FEMALE RATS Animal Number TRIG mg/dL GLUC mg/dL TP g/dL Female, Group: VI - 250 ing/kg - Day 44 641244 641251 641269 641292 641302 641362 641363 641375 641379 641398 16 98 6.8 26 109 7.0 43 84 7.1 56 103 6.7 28 105 6.8 29 102 6.5 46 117 7.7 41 101 6.8 31 116 7.0 24 101 7.2 Female, Group: VIII - 641237 17 641275 39 641279 34 641299 33 641300 35 641314 21 641326 16 641327 40 641380 26 641390 31 1000 mg/kg - 110 96 120 95 99 98 85 103 100 124 Day 44 7.5 7.4 7.9 7.5 7.0 7.0 7.2 7.7 7.5 8.3 ALB g/dL 4.4 4.9 5.0 4.7 4.8 4.7 5.5 4.8 4.5 5.0 5.5 5.4 5.7 5.4 4.9 4.7 5.1 5.3 4.9 5.8 GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L K mmol/L 2.4 10.5 2.1 10.6 2.1 11.2 2.0 10.6 2.0 10.2 1.8 10.0 2.2 10.8 2.0 10.1 2.5 10.5 2.2 10.9 2.0 10.3 2.0 10.9 2.2 11.1 2.1 11.0 2.1 10.3 2.3 10.5 2.1 11.0 2.4 11.0 2.6 10.3 2.5 RNV 8.0 145.8 6.8 145.5 8.4 146.6 9.7 143.1 6.2 146.9 6.5 147.7 6.6 146.1 7.3 144.5 7.6 147.2 8.3 145.9 7.1 147.5 6.9 147.2 7.9 147.9 8.3 146.1 7.7 144.6 8.5 144.4 8.2 147.4 7.8 146.2 8.4 144.2 8.2 146.1 5.88 6.02 6.20 6.05 5.54 6.11 5.46 6.27 6.11 6.44 5.89 5.70 6.46 6.04 6.08 6.36 6.05 6.39 5.69 6.68 727 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AMD PLASMA CHEMISTRY VALUES FOR FEMALE RATS Animal Number PLIP PICT PFLU Female/ Group: 11-0 mg/kg - Day 44 641240 NT NT NT 641245 NT NT NT 641249 NT NT NT 641257 NT NT NT 641283 NT NT NT 641290 NT NT NT 641293 NT NT NT 641335 NT NT NT 641344 NT NT NT 641384 NT NT MT Female, Group: IV - 50 mg/kg - Day 44 641260 NT" NT NT 641298 NT NT MT 641311 NT NT NT 641312 NT NT NT 641313 NT NT NT 641336 NT NT NT 641355 NT NT NT 641361 NT MT MT 641369 NT NT NT 641396 MT NT NT 728 'v^W' H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AMD PLASMA CHEMISTRY VALUES FOR FEMALE RATS Animal Number PLIP PICT PFLU Female, Group: VI - 250 ing/kg - Day 44 641244 NT NT NT 641251 NT NT NT 641263 NT NT NT 641292 NT NT NT 641302 NT NT NT 641362 NT NT NT 641363 NT NT NT 641375 NT NT NT 641379 NT NT NT 641398 NT NT NT Female, Group: 641237 641275 641279 641299 641300 641314 641326 641327 641380 641390 VIII - MTNT NT MT NT NT NT NT NT NT 1000 ing/kg - NT NT NT NT NT NT NT NT NT NT Day 44 NT NT NT NT NT NT NT NT NT NT 729 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR FEMALE RATS Animal Number SHEM SLIP SICT Female, Group: 641240 641245 641249 641257 641283 641290 641293 641335 641344 641384 11-0 NONE TRACE NSR NONE TRACE NONE NONE NONE TRACE NONE mg/kg - Day 92 NONE NOME NT NONE NONE NONE NONE NONE NONE NONE NONE NONE MT NONE NONE NONE NONE NONE NONE NONE Female, Group: IV - 50 mg/kg - Day 92 641260 641298 641311 641312 641313 641336 641355 641361 641369 641396 TRACENONE NONE TRACE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NOME NOME NONE AST IU/L 87 109 NT 93 82 66 103 115 70 63 114 77 84 101 82 85 151 106 126 207 ALT IU/L 28 58 NT 38 32 26 43 58 20 23 67 31 35 35 31 31 79 80 84 150 SDH IU/L 16.2 23.5 NT 20.1 20.6 22.0 20.8 33.0 17.8 22.1 27.8 20.4 19.6 18.1 17.1 27.5 26.2 26.1 25.5 55.8 ALKP IU/L BILI ing/dL BUN mg/dL 39 0.18 13 81 0.17 15 NT NT NT 47 0.18 15 48 0.18 16 31 0.24 14 88 0.12 15 53 0.19 17 27 0.21 16 41 0.18 11 54 0.17 17 46 0.17 16 66 0.16 16 54 0.21 15 50 0.20 18 114 0.11 16 66 0.10 23 55 0.14 12 37 0.15 19 36 0.19 15 730 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR FEMALE RATS Animal Number SHEM SLIP SICT Female, Group: VI - 250 mg/kg - Day 92 641244 641251 641269 641292 641302 641362 641363 641375 641379 641398 TRACE NOME NONE TRACE TRACE TRACE NONE TRACE NONE TRACE NONE NONE NONE NONE NONE NOME NONE NONE NOME NONE MOME NOME NOME NONE NONE NONE NOME MOME NOME MOME Female, Group: 641237 641275 641273 641299 641300 641314 641326 641327 641380 641390 VIII - NONE TRACE TRACE NONE NOME NONE NONE NONE HONE NONE 1000 mg/kg - NONE NONE NOME NOME NONE MOME NONE NOME NONE NONE Day 92 NONE MOME NONE NOME NONE NONE NONE NOME MOME MOME AST IU/L 89 66 117 91 77 82 68 72 137 70 160 87 80 99 71 83 77 68 120 61 ALT IU/L 35 37 41 58 30 37 34 38 106 34 66 35 27 41 35 40 36 28 55 31 SDH IU/L 19.4 19.6 28.7 25.5 19.0 19.9 17.8 20.1 30.6 19.7 15.2 21.0 20.6 20.0 16.3 19.1 21.2 20.6 27.7 19.1 ALKP IU/L BILI mg/dL BUM mg/dL 44 0.14 17 59. 0.17 19 70 0.15 15 50 0.17 18 66 0.18 16 56 0.16 15 35 0.19 14 35 0.16 14 42 0.12 16 45 0.11 16 40 0.13 20 62 0.11 17 48 <0.10 13 71 0.14 18 61 0.11 15 90 0.13 19 61 0.10 21 56 <0.10 18 61 0.11 20 28 0.11 17 731 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR FEMALE RATS Animal Number TRIG mg/dL GLUC mg/dL TP g/dL Female, Group: II - 0 nig/kg - Day 92 641240 39 113 7.9 641245 641249 48 101 7.5 NT NT NT 641257 57 102 8.0 641283 51 125 8.0 641290 127 129 8.5 641293 59 107 8.0 641335 41 157 7.9 641344 40 107 8.0 641384 52 115 7.9 Female, Group: IV - 50 mg/kg - Day 92 641260 641298 641311 641312 641313 641336 641355 641361 641369 641396 3L 107 7.4 60 114 7.9 38 106 8.3 40 108 8.3 26 95 7.0 75 142 8.1 72 114 8.1 35 109 8.0 78 101 7.6 72 118 9.0 ALB g/dL 5.2 4.7 NT 5.3 5.3 5.7 5.0 5.1 5.1 5.4 5.1 5.2 5.3 5.5 4.6 5.5 5.5 5.3 5.2 6.2 GLOB g/dL CALC mg/dL IPHS ing/dL NA mrnol/L K mmol/L 2.7 10.8 2.8 10.7 NT NT 2.7 11.1 2.7 11.1 2.8 12.0 3.0 11.1 2.8 10.9 2.9 11.2 2.5 11.2 2.3 2.7 3.0 2.8 2.4 2.6 2.6 2.7 2.4 2.8 11.1 11.1 11.3 11.0 10.6 11.2 11.4 11.0 11.3 11.8 RNV 146.7 5.5 148.3 NT NT 5.8 146.7 5.2 148.6 6.0 147.2 5.7 150.3 3.1 147.2 5.1 147.3 4.5 147.3 5.5 148.5 6.0 148.1 6.1 145.8 4.4 146.6 6.1 147.3 5.0 147.9 5.0 148.5 6.0 149.1 5.3 146.9 4.9 147.2 5.75 5.77 NT 5.29 5.30 5.80 5.84 5.44 6.01 5.86 5.58 6.12 5.58 5.57 5.22 5.72 5.97 5.76 5.81 5.32 732 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR FEMALE RATS Animal Number TRIG mg/dL GLUC mg/dL TP g/dL Female, Group; VI - 250 ing/kg - Day 92 641244 641251 27 96 7.6 55 106 7.9 641269 641292 54 102 7.9 77 122 7.9 641302 29 100 7.2 641362 26 105 6.9 641363 185 121 9.0 641375 50 112 7.4 641379 641398 36 120 8.1 44 105 7.5 Female, Group: VIII - 641237 41 641275 32 641279 44 641299 48 641300 55 641314 26 641326 41 641327 80 641380 47 641390 52 1000 ing/kg - 168 107 122 143 100 118 159 112 171 125 Day 92 8.0 8.0 8.4 8.1 6.8 7.8 8.0 8.8 7.9 8.9 ALB g/dL 4.9 5.4 5.2 5.3 4.8 4.9 6.0 5.1 5.3 5.1 5.5 5.5 5.8 5.6 4.7 5.0 5.4 5.7 5.3 6.0 GLOB g/dL CALC mg/dL IPHS NA K mg/dL inmol/L mmol/L m 2.7 10.8 2.5 11.5 2.7 12.0 2.6 11.1 2.4 10.7 2.0 11.0 3.0 12.1 2.3 10.5 2.8 11.2 2.4 11.3 2.5 10.6 2.5 11.2 2.6 11.3 2.5 11.0 2.1 10.9 2.8 10.9 2.6 11.4 3.1 11.5 2.6 11.0 2.9 11.9 5.4 147.7 5.1. 147.1 7.1 151.6 6.0 148.2 5.6 148.5 5.9 147.2 5.2 145.6 5.8 148.2 4.7 149.8 5.9 146.8 6.1 147.4 4.9 148.9 5.2 148.6 4.9 147.3 6.2 145.1 6.4 147.2 5.4 147.4 5.9 147.5 5.2 148.5 5.6 148.5 5.22 5.82 6.71 5.28 5.69 5.90 5.13 5.93 5.50 5.56 6.75 5.35 6.12 5.75 5.99 5.88 5.69 5.53 5.70 5.41 733 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AMD PLASMA CHEMISTRY VALUES FOR FEMALE RATS Animal Number PLIP PICT PFLU ^g/mL Female, Group: 11-0 mg/kg - Day 92 641240 NOME NOME 0.2 641245 NONE NONE 0.2 641249 NT NT MSR 641257 NONE MOME 0.2 641283 NONE NONE 0.3 641290 NONE NONE 0.2 641293 NONE NONE QNS 641335 NONE NONE 0.1 641344 NONE NONE 0.2 641384 NONE NONE 0.2 Female, Group: IV - 50 ing/kg - Day 92 641260 NONE- NONE 0.3 641298 NONE NONE 0.2 641311 NOME NOME 0.2 641312 NOME NONE 0.2 641313 NOME NONE 0.2 641336 NONE NONE 0.2 641355 NONE NOME 0.2 641361 NONE MOME 0.2 641369 NONE MOME 0.2 641396 NONE MOME 0.2 734 H-24616; Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AMD PLASMA CHEMISTRY VALUES FOR FEMALE RATS Animal Number PLIP PICT PFLU Aig/mL Female, Group: VI - 250 ing/kg - Day 92 641244 NONE NOME 0.2 641251 NONE NOME 0.2 641269 NONE HOME 0.1 641292 NONE NOME 0.2 641302 NONE NOME 0.2 641362 NONE NONE 0.1 641363 NONE NONE 0.2 641375 NONE HONE 0.2 641379 NONE NONE 0.3 641398 NONE NONE 0.2 Female, Group: VIII - 641237 641275 641279 641299 641300 641314 641326 641327 641380 641390 NONE NOME NONE NONE NONE NONE NONE MONE NOME NONE 1000 ing/kg - NONE NOME NOME NONE NOME NONE NONE NONE NONE NONE Day 92 0.2 0.3 0.2 0.2 0.2 0.2 0.3 0.2 0.3 0.2 735 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AMD PLASMA CHEMISTRY VALUES FOR FEMALE RATS Animal Number SHEM SLIP SICT Female, Group: 641253 641266 641281 641294 641325 641331 641359 641364 641383 641400 11-0 TRACE NONE NONE NONE NONE NOME TRACE NOME NOME NONE ing/kg - Day 124 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NOME NOME NONE NONE NONE Female, Group: VIII - 641234 641256 641282 641352 641356 641366 641377 641385 641387 641399 NONENONE NOME NONE NSR NONE NONE NONE NONE NONE 1000 mg/kg - NONE NONE NONE NONE NT NOME NONE NONE NONE NONE Day 124 NONE NONE NONE NONE NT NONE NOME NONE NONE NONE AST IU/L 69 107 120 90 98 102 99 88 142 99 76 69 74 65 NT 598 76 89 81 243 ALT IU/L SDH IU/L 26 20.6 48 26.1 89 28.9 96 24.9 93 28.4 58 18.9 37 23.6 40 24.8 108 38.8 44 26.0 39 15.1 36 16.7 31 19.0 32 13.1 NT NT 590 226.0 35 22.7 50 23.4 27 20.0 277 52.9 ALKP IU/L BILI mg/dL BUN mg/dL 40 0.12 15 37 0.18 15 38 0.16 16 41 0.18 14 33 0.21 14 72 0.17 10 51 0.12 13 32 0.10 16 27 0.15 15 32 0.10 17 60 0.11 14 29 <0.10 17 41 <0.10 15 36 0.13 14 NT NT NT 45 0.14 14 33 0.12 14 37 <0.10 17 76 0.12 14 35 <0.10 20 736 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AMD PLASMA CHEMISTRY VALUES FOR FEMALE RATS Animal Number TRIG mg/dL GLUC mg/dL TP g/dL Female/ Group; II - 0 mg/kg - Day 124 641253 83 90 7.3 641266 64 106 8.4 641281 62 123 9.0 641294 108 118 8.6 641325 52 112 9.3 641331 35 109 7.9 641359 53 96 7.7 641364 60 103 8.1 641383 54 110 8.7 641400 47 99 8.1 Female, Group: VIII - 1000 mg/kg - Day 124 641234 50- 115 7.7 641256 57 116 8.4 641282 105 100 8.1 641352 62 109 8.5 641356 NT NT NT 641366 54 102 8.5 641377 20 96 7.6 641385 58 85 8.5 641387 41 99 8.1 641399 . 53 118 8.3 ALB g/dL 4.7 5.5 6.2 5.7 6.5 5.6 5.2 5.3 6.0 5.5 5.4 6.1 5.0 5.8 NT 5.5 5.4 5.8 5.3 5.6 GLOB g/dL CALC mg/dL IPHS mg/dL NA inmol/L K inmol/L 2.6 11.1 2.9 11.8 2.8 12.3 2.9 12.0 2.8 12.4 2.3 11.2 2.5 11.0 2.8 11.5 2.7 11.9 2.6 11.4 2.3 11.1 2.3 11.8 3.1 11.8 2.7 11.9 NT NT 3.0 12.0 2.2 11.2 2.7 11.8 2.8 11.5 2.7 11.6 6.7 145.1 6.8' 146.2 7.5 145.5 6.3 144.9 5.6 146.1 5.7 146.8 6.5 146.8 6.0 145.1 6.1 145.2 5.8 145.3 6.6 145.9 6.4 147.1 7.4 149.2 6.1 145.9 NT NT 6.0 146.1 6.3 147.9 6.8 146.5 6.9 147.0 6.2 146.7 6.10 6.41 6.47 5.28 4.89 5.08 5.94 5.44 5.27 5.79 5.47 5.22 5.36 5.52 NT 5.18 5.95 5.30 5.43 5.22 737 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL SERUM AND PLASMA CHEMISTRY VALUES FOR FEMALE RATS Animal Number PLIP PICT PFLU Female, Group: 11-0 mg/kg - Day 124 641253 NT NT NT 641266 NT NT NT 641281 NT NT NT 641294 NT NT NT 641325 NT NT NT 641331 NT NT NT 641359 NT NT NT 641364 NT NT NT 641383 NT NT NT 641400 NT NT NT Female, Group: VIII - 641234 NT- 641256 NT 641282 NT 641352 NT 641356 NT 641366 NT 641377 NT 641385 NT 641387 NT 641399 NT 1000 ing/kg - NT NT NT NT MT MT NT NT NT NT Day 124 NT NT NT MT . NT NT NT NT NT NT 738 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URINALYSIS VALUES FOR MALE RATS Animal Number QUAL COL CLAR Male, Group: 641069 641070 641094 641147 641149 641155 641172 641206 641214 641222 1-0 nig/kg MEDIUM LIGHT LIGHT MEDIUM MEDIUM DARK MEDIUM LIGHT MEDIUM LIGHT - Day 44 YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR CLEAR CLEAR CLEAR CLOUDY CLEAR CLEAR HAZY CLEAR Male, Group: 641055 641056 641073 641081 641144 641146 641178 641198 641218 641224 III - 50 ing/kg - Day 44 MEDIUM LIGHT MEDIUM LIGHT MEDIUM MEDIUM MEDIUM LIGHT MEDIUM MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR CLOUDY CLEAR HAZY CLEAR HAZY HAZY CLEAR CLOUDY VOL UOSM SG mL mOsm/kg 9.4 11.0 16.0 7.0 4.8 8.4 13.4 1.0 4.8 18.0 13.4 12.8 7.0 12.0 12.0 10.2 11.0 22.0 4.6 14.0 1111 967 862 1017 1796 1200 1002 QNS 1705 628 779 627 1300 753 771 813 1121 .677 1692 921 1.037 1.029 1.026 1.033 1.055 1.038 1.030 1.025 1.055 1.021 1.024 1.020 1.041 1.024 1.024 1.025 1.036 1.022 1.053 1.029 PH UGLU KET ing/dL mg/dL 6.5 NEGATIVE 5 N 6.5 NEGATIVE 5 N 7.0 NEGATIVE 5 N 7.0 NEGATIVE 5 N 6.0 NEGATIVE 5 N 7.0 NEGATIVE 15 7.0 NEGATIVE NEGATIVE N 5.0 NEGATIVE 5 N 6.5 NEGATIVE 15 N 7.0 NEGATIVE 15 N 7.0 NEGATIVE NEGATIVE N 7.0 NEGATIVE 5 N 6.5 NEGATIVE 5 N 7.0 NEGATIVE 15 N 6.5 NEGATIVE 5 N 7.0 NEGATIVE 15 N 7.0 NEGATIVE 5 N 7.0 NEGATIVE 5 N 6.5 NEGATIVE 15 N 7.0 NEGATIVE 5 N 739 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URINALYSIS VALUES FOR MALE RATS Animal number QUAL COL CLAR Male, Group: V - 250 ing/kg - Day 44 641061 641089 641102 641134 641137 641162 641190 641197 641200 641202 MEDIUM MEDIUM MEDIUM MEDIUM NT MEDIUM LIGHT MEDIUM MEDIUM MEDIUM YELLOW YELLOW YELLOW YELLOW NT YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR CLEAR CLOUDY NT CLOUDY CLEAR CLEAR CLEAR CLEAR Male, Group: VII - 1000 nig/kg - Day 44 641067 641077 641086 641095 641097 641132 641157 641166 641201 641223 LIGHT LIGHT MEDIUM MEDIUM LIGHT DARK MEDIUM MEDIUM LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR CLEAR CLEAR CLEAR CLOUDY HAZY CLEAR CLEAR CLEAR VOL UOSM SG mL mOsm/kg 3.4 13.0 11.8 8.8 QNS 2.3 18.6 10.0 4.2 4.8 28.0 22.0 7.4 3.6 24.2 2.0 3.4 9.8 10.6 10.0 2771 629 924 959 QNS 2662 539 719 1854 1855 447 486 1347 2363 491 2306 2776 874 695 989 1.077 1.020 1.028 1.029 NT 1.076 1.018 1.024 1.056 1.058 1.014 1.016 1.044 1.069 1.016 1.070 1.076 1.027 1.023 1.030 pH UGLU KET mg/dL mg/dL 6.0 NEGATIVE 7.0 NEGATIVE 7.0 NEGATIVE 7.0 NEGATIVE NT NT 6.5 NEGATIVE 7.0 NEGATIVE 7.0 NEGATIVE 6.5 NEGATIVE 6.0 NEGATIVE 5 5 N 5 N 5 N NT 15 5 N 5 N 5 N 15 N 7.0 NEGATIVE 5 N 7.0 NEGATIVE NEGATIVE N 6.5 NEGATIVE 5 N 6.5 NEGATIVE 5 N 7.0 NEGATIVE NEGATIVE N 7.5 NEGATIVE 15 6.5 NEGATIVE 15 N 7.0 NEGATIVE 15 N 7.0 NEGATIVE 15 N 7.0 NEGATIVE 5 N 740 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URINALYSIS VALUES FOR MALE RATS Animal Number URO EU/dL UPLU UMTP ing/dL Male, Group: 1-0 nig/kg - Day 44 641069 0.2 641070 0.2 641094 0.2 641147 0.2 641149 0.2 641155 0.2 641172 0.2 641206 0.2 641214 0.2 641222 0.2 MT 111 NT 66 NT 53 NT 89 NT 151 NT 82 NT 60 NT 49 NT 186 NT 41 Male, Group: III - 50 ing/kg - Day 44 641055 0.2- 641056 0.2 641073 0.2 641081 0.2 641144 0.2 641146 0.2 641178 0.2 641198 0.2 641218 0.2 641224 0.2 NT 47 MT 23 NT 89 NT 42 NT . 46 NT 40 NT 62 NT 38 NT 157 NT 56 SPEC FEECCJAL CONTAMINATION OBSERVED SSaammi ple status: URINALYSIS TO BE RUN MANUALLY - FECiAL CONTAMINATION OBSERVED LOW VOLUME PFECGAL CONTAMINATION OBSERVED PFEECC;AL CONTAMINATION OBSERVED FEECQAL CONTAMINATION OBSERVED 741 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URINALYSIS VALUES FOR MALE RATS Animal Number UR 0 EU/d L UFLU TJMTP meT/dL Male, Group: V - 25 0 mg/'kg - Day 44 641061 1. 0 MT 220 641089 0. 2 NT 27 641102 0. 2 NT 51 641134 0. 2 NT 55 641137 MT QNS QMS 641162 1. 0 641190 0. 2 641197 0. 2 641200 0. 2 641202 0. 2 MT 85 MT 18 NT 32 MT 164 MT 94 Male, Group: VII - 1000 mg/kg - Day 44 641067 641077 641086 641095 641097 641132 641157 641166 641201 641223 0. 22". 0. 0. 2 0. 2 0. 2 1. 0 1. 0 0. 2 0. 2 0. 2 NT 18 MT 16 MT 96 NT 174 NT 14 NT 190 NT 160 NT 49 NT 27 NT 44 SPEC PFEECC.AL CONTAMINATION OBSERVED FEECC.AL CONTAMINATION OBSERVED FECC.AL COMTAMINATIOM OBSERVED 742 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URIMALYSIS VALUES FOR MALE RATS Animal Number QUAL COL CLAR Male, Group: 641069 641070 641094 641147 641149 641155 641172 641206 641214 641222 1-0 ing/kg MEDIUM MEDIUM LIGHT MEDIUM MEDIUM MEDIUM MEDIUM LIGHT MEDIUM MEDIUM - Day 91 YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR HAZY CLEAR CLOUDY HAZY HAZY CLEAR HAZY HAZY HAZY Male, Group: 641055 641056 641073 641081 641144 641146 641178 641198 641218 641224 III - 50 mg/kg - Day 91 LIGHTLIGHT MEDIUM LIGHT LIGHT MEDIUM MEDIUM LIGHT LIGHT MEPIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY HAZY CLEAR CLEAR CLEAR HAZY CLEAR CLEAR CLEAR HAZY VOL UOSM SG ItiL mOsm/kg 6.4 4.4 7.4 2.4 5.5 5.4 6.8 30.0 10.0 7.1 17.4 4.0 5.4 9.7 14.0 4.3 11.6 17.6 18.8 11.0 1279 1540 1344 1818 1252 1585 1376 465 837 1256 493 1192 1530 1016 746 1861 817 543 482 1220 1.042 1.049 1.041 1.056 1.040 1.049 1.044 1.017 1.027 1.039 1.016 1.038 1.047 1.030 1.025 1.055 1.027 1.018 1.017 1.039 PH UGLU KET mg/dL mg/dL 6.5 NEGATIVE 6.5 NEGATIVE 7.0 NEGATIVE 6.5 NEGATIVE 6.5 NEGATIVE 6.5 NEGATIVE 7.0 NEGATIVE 6.0 NEGATIVE 7.0 NEGATIVE 7.0 NEGATIVE 5 NE 5 NE 5 NE 5 NE 5 NE 5 5 NE 5 NE 5 NE 5 NE 6.5 NEGATIVE NEGATIVE NE 6.5 NEGATIVE 15 NE 7.0 NEGATIVE 5 NE 6.0 NEGATIVE 5 NE 6.0 NEGATIVE 7.0 NEGATIVE 6.0 NEGATIVE 7.0 NEGATIVE 5.5 NEGATIVE 6.5 NEGATIVE 5 NE 15 5 NE 5 NE 5 NE 5 NE 743 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URINALYSIS VALUES FOR MALE RATS Animal Number QUAL COL CLAR Male, Group: V - 250 mg/kg - Day 91 641061 641089 641102 641134 641137 641162 641190 641197 641200 641202 LIGHT MEDIUM MEDIUM LIGHT MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR HAZY HAZY HAZY HAZY HAZY HAZY HAZY HAZY CLEAR Male, Group: VII - 1000 mg/kg - Day 91 641067 641077 641086 641095 641097 641132 641157 641166 641201 641223 LIGHTLIGHT LIGHT MEDIUM LIGHT MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY CLEAR CLEAR CLEAR CLEAR CLOUDY CLEAR HAZY CLOUDY CLEAR VOL UOSM SG mL BiOsm/kg 9.8 6.8 4.3 5.7 6.4 3.3 11.0 3.6 1.7 4.4 17.2 20.2 7.8 7.8 12.0 8.5 4.0 7.4 3.4 5.8 852 1175 1541 1507 1599 2855 1680 2066 3308 1897 509 587 1031 1046 715 1257 2145 1151 910 1401 1.027 1.037 1.048 1.045 1.049 1.077 1.028 1.061 1.083 1.058 1.017 1.019 1.033 1.034 1.023 1.040 1.063 1.035 1.053 1.044 PH UGLU KET mg/dL mg/dL 6.0 NEGATIVE 6.5' NEGATIVE 7.5 NEGATIVE 7.0 NEGATIVE 6.5 NEGATIVE 6.5 NEGATIVE 6.0 NEGATIVE 7.0 NEGATIVE 6.5 NEGATIVE 6.0 NEGATIVE 5 NE 5 NE 5 NE 5 NE 5 15 NE 5 NE 5 NE 5 NE 15 NE 6.0 NEGATIVE 6.0 NEGATIVE 7.0 NEGATIVE 6.5 NEGATIVE 5 NE 5 NE 5 NE 5 NE 6.5 NEGATIVE NEGATIVE NE 7.5 NEGATIVE 6.0 NEGATIVE 7.5 NEGATIVE 6.5 NEGATIVE 6.5 NEGATIVE 15 5 NE 15 NE 15 5 NE 744 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL UKINALYSIS VALUES FOR MALE RATS Animal Number URO EIJ/dL UF:LU 'v-g UMTP i ng/dL Male, Group: I - 0 ing/kg - Day 91 641069 0.2 8 .9 147 641070 0.2 9 .9 142 641094 0.2 10 .5 99 641147 1.0 QNS 40 641149 0.2 8 .9 108 641155 1.0 12 .3 92 641172 0.2 10 .4 77 641206 0.2 19 .4 40 641214 0.2 13 .6 79 641222 0.2 15 .6 101 Male, Group: III - 50 ing/kg - Day 91 641055 0.2- 18 .4 22 641056 0.2 8 .7 82 641073 0.2 11 .2 98 641081 0.2 11 .7 35 641144 0.2 12 .6 54 641146 1.0 12 .0 128 641178 0.2 19 .2 29 641198 0.2 16 .5 22 641218 0.2 15 .3 22 641224 0.2 15 .4 77 SPEC 745 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URIMALYSIS VALUES FOR MALE RATS Animal Number U RO EU/.3L UFLU 4g 1IMTP m<?/dL Male, Group: V - 2 50 mg/'kg - Day 91 641061 0 .2 27.6 38 641089 0 .2 21.8 60 641102 0 .2 21.1 119 641134 0 .2 21.8 78 641137 0 .2 30.5 83 641162 1 .0 32.5 MV 641190 0 .2 22.4 101 641197 1 .0 21.9 148 641200 1 .0 QNS 55 641202 0 .2 24.7 92 Male, Group: VII - 1000 mg/kg - Day 91 641067 0 .2" 45.2 41 641077 0.2 42.2 18 641086 0 .2 40.7 50 641095 0 .2 50.3 30 641097 0 .2 43.6 21 641132 0 .2 63.1 77 641157 1 .0 42.0 75 641166 0 .2 37.9 42 641201 1 .0 8.7 29 641223 0 .2 53.3 65 SPEC 746 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URINALYSIS VALUES FOR MALE RATS Animal Number QUAL COL CLAR Male, Group: 641083 641084 641085 641101 64110S 641123 641154 641159 641165 641215 1-0 ing/kg MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM LIGHT LIGHT MEDIUM - Day 123 YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY HAZY CLEAR CLEAR CLEAR HAZY CLEAR CLEAR CLEAR CLEAR Male, Group: VII - 1000 nig/kg - Day 123 641064 641092 641143 641153 641167 641185 641189 641203 641213 641216 MEDIUM. MEDIUM MEDIUM DARK LIGHT MEDIUM LIGHT LIGHT MEDIUM MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY HAZY HAZY CLOUDY HAZY CLEAR HAZY HAZY HAZY CLEAR VOL UOSM SG mL mOsm/kg 3.4 3095 1.083 4.1 1630 1.051 2.3 1757 1.055 4.5 2628 1.071 4.5 1390 1.046 3.6 1982 1.059 4.2 1766 1.055 9.8 539 1.017 3.2 1214 1.037 4.3 2225 1.066 3.0 3215 1.083 4.1 2464 1.069 3.1 2380 1.071 3.2 2545 ' 1.069 8.2 1199 1.037 3.3 2155 1.065 9.0 900 1.027 9.8 928 1.028 7.9 1200 1.040 2.8 1924 1.061 PH UGLU KET mg/dL mg/dL 6.0 NEGATIVE 6.5 NEGATIVE 6.0 NEGATIVE 6.5 NEGATIVE 6.0 NEGATIVE 7.5 NEGATIVE 6.0 NEGATIVE 8.5 NEGATIVE 5.5 NEGATIVE 6.5 NEGATIVE 15 5 NE 15 NE 15 NE 15 NE 15 NE 15 NE 5 NE 15 NE 5 NE 6.5 NEGATIVE 7.0 NEGATIVE 6.0 NEGATIVE 8.5 NEGATIVE 7.5 NEGATIVE 15 NE 15 NE 15 NE 15 5 NE 6.5 NEGATIVE 5 NE 8.0 NEGATIVE NEGATIVE NE 7.5 NEGATIVE 5 NE 7.5 NEGATIVE 6.0 NEGATIVE 5 NE 15 NE 747 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URINALYSIS VALUES FOR MALE RATS Animal Number U RO ETJ/ dL UP L U ^g UMTP mg/dL Male, Group: T -- 0 ing/kg - Day 123 641083 1 .0 16 .5 185 641084 0 .2 6 .0 174 641085 0 .2 6 .6 140 641101 0 .2 19 .7 186 641105 0 .2 8 .0 109 641123 0 .2 11 .4 168 641154 0 .2 7 .2 123 641159 0 .2 8 .8 26 641165 0 .2 5 .0 61 641215 0 .2 13 .5 240 Male, Group: VII - 1000 ing/kg - Day 123 641064 641092 641143 641153 641167 641185 641189 641203 641213 641216 1 .0" 0 .2 0 .2 1 .0 0 .2 0 .2 0 .2 0 .2 0 .2 0 .2 15.7 19 .3 5 .2 12 .3 17 .1 12 .9 16 .5 18 .7 18 .8 11 .6 192 175 159 197 .55 162 34 39 97 184 SPEC PFEECGAL CONTAMINATION OBSERVED FFEECCJAL CONTAMINATION OBSERVED 748 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URINALYSIS VALUES FOR FEMALE RATS Animal Number QUAL COL CLAR Female, Group: 11-0 mg/kg - Day 44 641240 641245 641249 641257 641283 641290 641293 641335 641344 641384 MEDIUM LIGHT MEDIUM MEDIUM LIGHT MEDIUM LIGHT MEDIUM MEDIUM MT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW NT CLEAR CLEAR HAZY CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR NT Female, Group: IV - 50 Big/kg - Day 44 641260 641298 641311 641312 641313 641336 641355 641361 641369 641396 LIGHTLIGHT MEDIUM NT MEDIUM MEDIUM LIGHT MEDIUM MEDIUM LIGHT YELLOW YELLOW YELLOW NT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR CLEAR NT CLEAR HAZY CLEAR CLEAR CLEAR CLEAR VOL UOSM SG mL mOsm/kg 10.8 21.6 13.2 4.0 22.0 9.0 17.0 9.0 7.2 QNS 13.4 12.6 7.6 QNS 5.0 5.2 17.8 11.0 1.5 13.2 959 348 591 970 413 803 464 810 1057 QKS 1.028 1.011 1.019 1.030 1.013 1.025 1.014 1.024 1.030 NT 456 578 987 QNS 1300 1124 342 716 QNS 604 1.014 1.018 1.029 NT 1.041 1.036 1.011 1.022 1.056 1.019 pH UGLU KET mg/dL mg/dL 6.5 NEGATIVE NEGATIVE NE 6.0' NEGATIVE NEGATIVE NE 7.0 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 6.5 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 7.0 NEGATIVE NEGATIVE NE 6.5 NEGATIVE NEGATIVE NE 6.5 NEGATIVE NEGATIVE NE MT NT NT 6.5 NEGATIVE NEGATIVE NE 6.5 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE NT NT NT 6.5 NEGATIVE NEGATIVE NE 6.5 NEGATIVE NEGATIVE NE 6.5 NEGATIVE NEGATIVE NE 6.5 NEGATIVE NEGATIVE NE 6.0 NEGATIVE 5 6.5 NEGATIVE NEGATIVE NE 749 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URINALYSIS VALUES FOR FEMALE RATS Animal Number QUAL COL CLAR Female, Group: VI - 250 ing/kg - Day 44 641244 641251 641269 641292 641302 641362 641363 641375 641379 641398 MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM NT LIGHT MEDIUM MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW NT YELLOW YELLOW YELLOW CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR NT CLEAR CLEAR CLEAR Female, Group: VIII - 641237 641275 641279 641299 641300 641314 641326 641327 641380 641390 MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM LIGHT MEDIUM MEDIUM LIGHT 1000 ing/kg - YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW Day 44 CLEAR HAZY CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR CLOUDY CLEAR VOL UOSM SG BiL mOsm/kg 4.3 5.2 3.4 11.6 1.0 2.0 QNS 15.0 8.0 11.4 5.2 7.4 5.0 5.0 8.8 3.4 7.8 6.0 4.4 15.0 1178 907 1659 669 QNS 1937 QNS 526 803 623 984 807 1158 956 684 2003 689 1282 1576 525 1.036 1.027 1.050 1.021 1.064 1.057 NT 1.016 1.024 1.019 1.028 1.024 1.036 1.029 1.022 1.059 1.021 1.039 1.048 1.017 pH UBLU KET mg/dL mg/dL 6.0 NEGATIVE NEGATIVE NE 6.5 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NE 7.0 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE NT NT NT 6.5 NEGATIVE NEGATIVE NE 6.5 NEGATIVE NEGATIVE NE 6.5 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 6.5 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NE 6.5 NEGATIVE NEGATIVE NE 6.5 NEGATIVE NEGATIVE NE 7.0 NEGATIVE NEGATIVE NE 750 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URINALYSIS VALUES FOR FEMALE RATS Animal Number URO EU/dL UPLU UMTP rtig/dL Female, Group; II - 0 nig/kg - Day 44 641240 0.2 641245 0.2 641249 0.2 641257 0.2 641283 0.2 641290 0.2 641293 0.2 641335 0.2 641344 0.2 641384 NT 16 NT <6 NT 14 NT 25 MT 8 NT 15 NT <6 NT 15 NT 9 NT QNS ale. Group: IV - 50 g/kg - Day 44 641260 641298 641311 641312 641313 641336 641355 641361 641369 641396 0.20.2 0.2 NT 0.2 0.2 0.2 0.2 0.2 .0.2 NT 6 NT 8 NT 19 NT QNS NT 16 NT 28 NT 7 NT 11 MT 56 NT 8 SPEC FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED Sample status: URINALYSIS TO BE RUN MANUALLY - LOW VOLUME 751 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URIMALYSIS VALUES FOR FEMALE RATS Animal Number URO EU/dL UPLU UMTP ing/dL Female, Group: VI - 250 ing/kg - Day 44 641244 0.2 641251 0.2 641269 0.2 641292 0.2 641302 0.2 641362 0.2 641363 NT 641375 0.2 641379 0.2 641398 0.2 NT 17 NT 19 MT 23 NT 12 NT 54 MT 33 NT QMS NT 9 MT 18 MT 9 Female, Group: VIII - 641237 0.2 641275 0.2 641279 0.2 641299 0.2 641300 0.2 641314 0.2 641326 0.2 641327 0.2 641380 0.2 641390 .0.2 1000 rng/kg - NT NT MT MT NT NT NT NT MT MT Day 44 16 15 18 21 . 15 41 8 21 45 9 SPEC SSaammi ple ststus: URIMALYSIS TO BE RUN MAMUALLY - LOW VOLUME FECiAL CONTAMINATION OBSERVED 752 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URIMALYSIS VALUES FOR FEMALE RATS Animal Number QUAL COL CLAR Female, Group: 11-0 ing/kg - Day 92 641240 641245 641249 641257 641283 641290 641293 641335 641344 641384 LIGHT LIGHT MEDIUM LIGHT MEDIUM MEDIUM LIGHT MEDIUM LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR HAZY CLEAR CLEAR Feinal e, Group; IV - 50 mg/kg - Day 92 641260 641298 641311 641312 641313 641336 641355 641361 641369 641396 MEDIUM. MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM LIGHT MEDIUM MEDIUM MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR HAZY HAZY CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR VOL UOSM SG inL mOsin/kg 13.0 8.7 8.0 16.2 4.4 8.1 9.4 6.1 5.9 6.4 3.8 7.1 4.9 2.7 3.2 4.5 4.4 4.0 3.0 5.2 544 646 1170 447 1401 1098 692 1018 829 754 1215 933 1057 1987 1893 1262 608 1278 1322 992 1.018 1.020 1.034 1.015 1.043 1.034 1.020 1.030 1.025 1.024 1.038 1.028 1.031 1.058 1.054 1.040 1.020 1.038 1.041 1.030 PH UGLU KET mg/dL mg/dL 6.0 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 7.5 NEGATIVE NEGATIVE NE 5.5 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 6.5 NEGATIVE NEGATIVE NE 5.5 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 5.5 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 5.5 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 5.5 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 753 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URINALYSIS VALUES FOR FEMALE RATS Animal Number QUAL COL CLAR Female, Group: VI - 250 mg/kg - Day 92 641244 641251 641269 641292 641302 641362 641363 641375 641379 641398 MEDIUM MEDIUM MEDIUM LIGHT LIGHT MEDIUM MEDIUM LIGHT MEDIUM LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY CLEAR HAZY CLEAR HAZY HAZY CLEAR HAZY CLEAR HAZY Female, Group: VIII - 641237 641275 641279 641299 641300 641314 641326 641327 641380 641390 MEDIUMMEDIUM NT MEDIUM LIGHT MEDIUM MEDIUM LIGHT MEDIUM LIGHT 1000 mg/kg - YELLOW YELLOW NT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW Day 92 CLEAR HAZY NT CLOUDY CLEAR CLEAR CLOUDY CLEAR CLEAR HAZY VOL UOSM SG mL mOsm/kg 4.4 5.1 3.7 5.6 11.6 6.2 1.5 10.0 6.5 3.0 2.1 2.7 NSR 1.8 15.6 2.7 2.5 8.6 3.0 13.6 1598 1016 1320 1188 447 1070 2508 785 1053 695 1810 1686 NT 2036 438 2280 1163 705 1461 606 1.047 1.030 1.041 1.037 1.015 1.031 1.073 1.024 1.031 1.022 1.053 1.051 MT 1.061 1.015 1.065 1.036 1.022 1.046 1.020 pH UGLU KET mg/dL mg/dL 6.5 NEGATIVE NEGATIVE NE 5.5' NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 5.S NEGATIVE NEGATIVE NE 6.5 NEGATIVE NEGATIVE NE 5.5 NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE NT NT NT 6.0 NEGATIVE 5 6.0 NEGATIVE NEGATIVE NE 5.5 NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 6.5 NEGATIVE NEGATIVE NE 5.5 NEGATIVE NEGATIVE NE 754 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URINALYSIS VALUES FOR FEMALE RATS Animal Mmnber URO EU/dL UPLU US UMTP mg/dL Female, Group: II - 0 mg/kg - Day 92 641240 0.2 11 .1 12 641245 0.2 9 .1 17 641249 0.2 13 .4 21 641257 0.2 9 .0 9 641283 0.2 6 .8 30 641290 0.2 10 .7 39 641293 0.2 7 .8 7 641335 0.2 10 .8 18 641344 0.2 6 .3 14 641384 0.2 10 .0 22 lale. Group: IV - 50 mg/kg - 1Day 92 641260 0.2- 7 .7 27 641298 0.2 12 .9 15 641311 0.2 6 .5 25 641312 1.0 10 .0 42 641313 0.2 9 .0 25 641336 0.2 10 .5 33 641355 0.2 5 .2 16 641361 0.2 7 .7 25 641369 0.2 6 .2 21 641396 .0.2 6 .5 23 SPEC 755 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URINALYSIS VALUES FOR FEMALE RATS Animal Number URO EU/dL UFLU fig UMTP mg/dL Female, Group: VI - 250 ing/kg - Day 92 641244 0.2 14.6 26 641251 0.2 12.9 17 641269 0.2 12.6 25 641292 0.2 10.7 21 641302 0.2 15.2 7 641362 0.2 16.1 15 641363 1.0 QNS 408 641375 0.2 21.7 12 641379 0.2 16.2 24 641398 0.2 5.7 10 Female, Group: VIII - 641237 0.2- 641275 0.2 641279 NT 641299 1.0 641300 0.2 641314 1.0 641326 0.2 641327 0.2 641380 0.2 641390 0.2 1000 mg/kg - QNS 18.0 NSR QNS 33.6 26.5 10.1 27.7 20.1 30.1 Day 92 37 35 NSR 92 6 . 53 11 15 37 10 SPEC 756 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URINALYSIS VALUES FOR FEMALE RATS Animal Number QUAL COL CLAR Female, Group: 11-0 641253 641266 641281 641294 641325 641331 641359 641364 641383 641400 MEDIUM LIGHT MEDIUM MEDIUM MEDIUM LIGHT MEDIUM MEDIUM LIGHT LIGHT ing/kg - Day YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW 124 CLOUDY CLEAR CLEAR HAZY CLEAR CLEAR CLEAR HAZY HAZY CLEAR Female, Group: VIII - 641234 641256 641282 641352 641356 641366 641377 641385 641387 641399 LIGHT MEDIUM MEDIUM MEDIUM NT MEDIUM MEDIUM LIGHT MEDIUM LIGHT 1000 ing/kg - YELLOW YELLOW YELLOW YELLOW NT YELLOW YELLOW YELLOW YELLOW YELLOW Day 124 CLEAR CLEAR HAZY CLEAR NT HAZY CLEAR CLEAR HAZY HAZY VOL UOSM SG mL mOsm/kg 8.6 6.8 1.9 4.0 2.7 10.4 3.0 4.5 13.4 10.0 7.7 5.8 4.1 4.6 MSR 3.8 3.0 7.8 4.2 5.7 1116 1253 2781 1555 1592 471 1639 1446 538 515 1.035 1.039 1.078 1.050 1.048 1.018 1.051 1.046 1.018 1.017 705 1122 1883 1150 . NT 1122 1579 840 1550 1088 1.023 1.036 1.056 1.037 NT 1.037 1.048 1.026 1.049 1.036 PH UGLU KET TOg/dL mg/dL 7.5 NEGATIVE NEGATIVE NE 6.0 NEGATIVE NEGATIVE NE 5.0 NEGATIVE NEGATIVE NE 5.5 NEGATIVE NEGATIVE N 5.5 NEGATIVE NEGATIVE N 5.0 NEGATIVE NEGATIVE NE 5.5 NEGATIVE NEGATIVE N 6.0 NEGATIVE 5 N 5.5 NEGATIVE NEGATIVE N 5.5 NEGATIVE NEGATIVE N 6.0 NEGATIVE NEGATIVE N 5.5 NEGATIVE NEGATIVE N 6.0 NEGATIVE NEGATIVE N 5.5 NEGATIVE NEGATIVE N NT NT NT 5.5 NEGATIVE NEGATIVE NE 6.0 NEGATIVE 5 N 5.5 NEGATIVE NEGATIVE N 6.0 NEGATIVE NEGATIVE N 6.0 NEGATIVE NEGATIVE N 757 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ORINALYSIS VALUES FOR FEMALE RATS Animal Number URO EU/dL UFLU M UMTP mg/dL Female, Group: 11-0 mg/kg - Day 124 641253 0.2 5.7 43 641266 0.2 11.4 24 641281 0.2 NT 73 641294 0.2 9.9 42 641325 0.2 5.8 58 641331 0.2 16.3 9 641359 0.2 4.5 46 641364 0.2 9.2 36 641383 0.2 9.8 15 641400 0.2 10.1 8 Female, Group: 641234 641256 641282 641352 641356 641366 641377 641385 641387 641399 VIII - 0.20.2 0.2 0.2 MT 0.2 0.2 0.2 0.2 0.2 1000 mg/kg - 12.0 11.1 14.3 11.0 NSR 6.9 7.5 11.1 10.0 12.0 Day 124 18 15 47 24 NSR 48 24 18 38 39 SPEC FECGAL CONTAMINATION OBSERVED PFEECC.AL CONTAMINATION OBSERVED 758 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URINE MICROSCOPIC VALUES FOR MALE RATS Animal Number EPIT UWBC URBC Male, Group: 1-0 ing/kg - Day 44 641069 MOME 1-10 0 641070 FEW 1-10 0 641094 FEW 0 0 641147 FEW 0 0 641149 PEW 1-10 0 641155 FEW 1-10 0 641172 NONE 0 0 641206 FEW 1-10 0 641214 FEW 1-10 0 641222 FEW 1-10 0 Male, Group; III - 50 mg/kg - Day 44 641055 FEW 0 0 641056 FEW 1-10 0 641073 FEW 1-10 0 641081 NONE 0 0 641144 PEW 0 0 641146 PEW 1-10 0 641178 FEW 1-10 0 641198 NONE 0 0 641218 MOME 1-10 0 641224 FEW 0 0 MCRY MICR NOME FEW FEW NONE NOME PEW NONE FEW FEW FEW FEW MODERATE MODERATE MODERATE FEW MODERATE FEW FEW FEW PEW FEW NONE FEW FEW NONE PEW FEW FEW NONE FEW PEW FEW PEW FEW MODERATE FEW FEW FEW PEW MODERATE SPER SPEC 0 1 2 2 2 3 FEW GGRRJANULAR CASTS 0 3 Ssample status: BELOW RECOMMENDED 2 1 1 1 2 1 2 0 3 1 2 1 759 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URINE MICROSCOPIC VALUES FOR MALE RATS Animal Number EPIT UWBC ORBC NCRY MICR Male, Group: V - 250 ing/kg - Day 44 641061 NOME 0 0 641089 FEW 0 0 641102 NONE 0 0 641134 FEW 1-10 0 641137 NT NT NT 641162 FEW 0 0 641190 FEW 0 0 641197 FEW 1-10 0 641200 FEW 1-10 0 641202 FEW 1-10 0 Male, Group: VII - 1000 ing/kg - Day 44 641067 NONE 0 0 641077 NONE 0 0 641086 FEW 1-10 0 641095 FEW 1-10 0 641097 FEW 0 0 641132 PEW 0 0 641157 PEW 1-10 0 641166 FEW 0 0 641201 FEW 1-10 0 641223 NONE 0 0 NONE NONE FEW PEW NT FEW NONE NONE NONE NONE NONE NONE NONE NONE NONE MODERATE FEW NONE NONE NONE MODERATE FEW PEW PEW NT MODERATE FEW FEW FEW FEW MODERATE FEW FEW FEW MODERATE MANY PEW FEW PEW FEW SPER 2 1 1 3 NT 1 0 0 2 2 2 2 0 1 0 0 3 1 0 0 SPEC 760 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URINE MICROSCOPIC VALUES FOR MALE RATS Animal Number EPIT UWBC URBC Male/ Group: 1-0 ing/kg - 641069 641070 641094 641147 641149 641155 641172 641206 641214 641222 FEW FEW FEW MODERATE FEW NOME FEW NONE FEW FEW Day 91 0 0 0 1-10 0 0 0 0 0 0 Male, Group: 641055 641056 641073 641081 641144 641146 641178 641198 641218 641224 III - 50 nig/kg - NOMEFEW FEW FEW MONE NOME FEW FEW NOME FEW Day 91 0 0 0 0 0 0 0 0 0 0 0 0 0 1-10 1-10 0 0 0 0 0 0 0 0 1-10 0 0 0 1-10 0 0 NCRY MICR NOME PEW FEW NONE NONE FEW NOME NONE FEW PEW MODERATE MODERATE MANY MANY MODERATE MODERATE MODERATE MODERATE FEW MODERATE NONE NONE FEW NONE NOME FEW NONE NONE NONE NOME MODERATE MODERATE MODERATE FEW MANY MODERATE MODERATE FEW FEW MAMY SPER SPEC 3 3 1-MUCUS 3 3 3 3 1 3 3 3 1-MUCUS 2 3 1-MUCUS 1 1-MUCUS 1 1-MUCUS 2 1-MUCUS 2 1-MUCUS 3 0 2 1 1-MUCUS 761 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URIME MICROSCOPIC VALUES FOR MALE RATS Animal Mumber EPIT UWBC URBC MCRY MICR Male, Group: V - 250 ing/kg - Day 91 641061 641089 641102 641134 641137 641162 641190 641197 641200 641202 NOME NOME FEW NONE NOME FEW NONE FEW FEW FEW 0 0 0 0 1-10 0 0 0 0 0 0 0 0 0 1-10 1-10 0 0 0 0 Male, Group: VII - 1000 ing/kg - Day 91 641067 641077 641086 641095 641097 641132 641157 641166 641201 641223 FEW PEW PEW NONE FEW FEW NONE FEW FEW MOME 0 0 0 0 0 1-10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 MONE MONE FEW PEW NONE FEW NOME FEW MODERATE NONE NONE NONE NOME NOME NOME FEW MONE MODERATE FEW FEW FEW MODERATE FEW MODERATE MODERATE MANY FEW FEW MANY MODERATE FEW FEW MODERATE MANY . FEW MANY FEW FEW MANY FEW SPER 2 3 2 3 3 1 3 2 2 1 3 3 1 2 3 2 3 3 3 1 SPEC 2-MUCUS 2-MUCUS Sample status: 1-MUCUS BELOW RECOMMEMDED 1-MUCUS 1-MUCUS 1-MUCUS 762 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URIME MICROSCOPIC VALUES FOR MALE RATS Animal Number EPIT UWBC URBC NCRY MICR Male, Group: 1-0 ing/kg - Day 123 641083 FEW 0 0 641084 FEW 1-10 0 641085 FEW 1-10 0 641101 NONE 0 0 641105 FEW 0 0 641123 NONE 0 0 641154 NOME 1-10 0 641159 NOME 0 0 641165 NONE 0 0 641215 FEW 0 0 Male, Group: VII - 1000 mg/kg - Day 123 641064 FEW 1-10 0 641092 NOME 0 0 641143 NONE 0 0 641153 NONE 0 0 641167 NOME 0 0 641185 PEW 1-10 0 641189 MONE 0 0 641203 NONE 0 0 641213 NOME 0 0 641216 FEW 1-10 0 FEW FEW NOME FEW NONE MODERATE NONE FEW FEW FEW FEW MODERATE FEW PEW MODERATE NONE PEW FEW PEW MODERATE FEW FEW FEW PEW FEW FEW PEW MODERATE FEW FEW PEW PEW FEW FEW MODERATE FEW FEW FEW FEW FEW SPER SPEC 3 3 3 2 3 3 1-MUCUS 1 1-MUCUS 2 1 1 1-MUCUS 2 1-MUCUS 1 1-MUCUS 3 3 2 3 2 1 1 1-MUCUS 3 763 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URINE MICROSCOPIC VALUES FOR FEMALE RATS Animal Number EPIT UWBC URBC Female, Group: 11-0 nig/kg - Day 44 641240 FEW 0 0 641245 NONE 1-10 0 641249 FEW 1-10 0 641257 FEW 0 0 641283 NONE 0 0 641290 NONE 0 0 641293 NONE 0 0 641335 NONE 0 0 641344 NONE 0 0 641384 NT NT NT Female, Group: IV - 50 ing/kg - Day 44 641260 641298 641311 641312 641313 641336 641355 641361 641369 641396 PEW NOME PEW NT FEW NONE PEW NONE FEW NONE 0 0 1-10 NT 1-10 0 0 0 1-10 0 0 0 0 NT 0 . 0 0 0 0 0 MCRY NONE FEW NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NOME MT NOME NOME MOME NOME FEW NOME MICR FEW FEW PEW FEW FEW PEW PEW FEW FEW NT NOME FEW FEW NT FEW FEW FEW FEW FEW FEW SPER SPEC 0 0 0 0 0 0 0 0 0 NT 0 0 0 NT 0 0 0 0 0 Sample 0 BELOW RECOMMENDED 764 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URINE MICROSCOPIC VALUES FOR FEMALE RATS Animal Number EPIT UWBC URBC NCRY MICR Female, Group: VI - 250 nig/kg - Day 44 641244 FEW 1-10 0 641251 NONE 0 0 641269 NONE 0 0 641292 NONE 0 0 641302 FEW 1-10 0 641362 NONE 0 0 641375 FEW 1-10 0 641379 NONE 0 0 641398 NONE 0 0 Female, Group: VIII - 641237 641275 641279 641299 641300 641314 641326 641327 641380 641390 FEW NONE FEW NONE NONE NONE NONE NOME NONE NONE 1000 ing/kg - 0 0 0 1-10 1-10 0 0 1-10 0 1-10 Day 44 0 0 0 0 0 0 0 0 0 0 NONE NONE NONE NONE NONE FEW NONE NONE NONE NONE NONE FEW NONE NONE NONE NONE NONE MODERATE NONE FEW FEW MODERATE FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW MODERATE MODERATE FEW MANY FEW SPER SPEC 0 0 0 0 0 Sample status: BELOW RECOMMENDED FEW GRUANULAR CASTS 0 0 0 0 0 0 0 0 0 0 0 0 0 0 765 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URINE MICROSCOPIC VALUES FOR FEMALE RATS Animal Number EPIT UWBC URBC MCRY MICR Female, Group: 641240 641245 641249 641257 641283 641290 641293 641335 641344 641384 11-0 nig/kg - Day 92 FEW NONE FEW FEW FEW FEW FEW PEW FEW FEW 0 0 0 0 0 0 0 1-10 0 0 Female, Group: IV - 50 mg/kg - Day 92 641260 641298 641311 641312 641313 641336 641355 641361 641369 641396 FEWFEW PEW FEW FEW FEW PEW NOME FEW FEW 0 1-10 1-10 1-10 1-10 0 0 0 1-10 0 0 FEW FEW 0 FEW FEW 0 PEW PEW 0 FEW FEW 0 FEW PEW 0 FEW FEW 0 MODERATE MODERATE 0 MODERATE MODERATE 0 MODERATE FEW 0 MODERATE MODERATE 0 MODERATE FEW 0 MODERATE MODERATE 0 MODERATE MODERATE 0 MODERATE MODERATE 0 FEW MODERATE 0 MODERATE FEW 0 FEW PEW 0 FEW FEW 0 MODERATE MODERATE 0 FEW FEW SPER SPEC 0 0 0 0 0 0 0 0 0 0 0 0 0 1-MUCU!S 0 Sample status: BELOW RECOMMENDED 0 0 0 1-MUCUI 0 1-MUCUI 0 Sample 0 766 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URINE MICROSCOPIC VALUES FOR FEMALE RATS Animal Number EPIT UWBC URBC NCRY MICR Female, Grcsup: VI - 2E?0 mg/kg - E3ay 92 641244 FEW 1-10 0 641251 NOME 0 0 641269 FEW 0 0 641292 FEW 1-10 0 641302 FEW 0 0 641362 MODERATE 1-10 0 641363 FEW 0 0 641375 NOME 0 0 641379 NONE 0 0 641398 PEW 0 0 Female, Group: VIII - 641237 641275 641279 641299 641300 641314 641326 641327 641380 641390 FEWFEW NT MODERATE FEW FEW MODERATE FEW FEW NONE 1000 mg/kg - 1-10 0 NT 1-10 0 1-10 1-10 0 1-10 1-10 Day 92 0 0 NT 0 0 0 0 0 0 0 FEW MODERATE MODERATE FEW MODERATE MODERATE MODERATE FEW FEW MANY MODERATE MODERATE NT MANY FEW MODERATE MANY PEW MODERATE FEW FEW MODERATE FEW FEW MODERATE FEW FEW FEW FEW MANY MODERATE MANY NT MANY FEW MODERATE MODERATE FEW MODERATE FEW SPER SPEC 0 0 0 0 1-MUCUS3 0 0 1-MUCUS 0 Sample status: BELOW RECOMMENDED 0 0 0 Sample status: BELOW RECOMMENDED 0 Sample status BELOW RECOMMENDED 0 Sample status BELOW RECOMMENDED NT 0 Sample status BELOW RECOMMENDED 0 0 Sample status BELOW RECOMMENDED 0 Sample status BELOW RECOMMENDED 0 0 Sample status BELOW RECOMMENDED 0 767 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL URIME MICROSCOPIC VALUES FOR FEMALE RATS Animal Number EPIT UWBC URBC Female, Group: 11-0 mg/kg - Day 124 641253 MOME 0 0 641266 FEW 1-10 0 641281 NOME 0 0 641294 FEW 0 0 641325 FEW 0 0 641331 NOME 1-10 0 641359 NONE 0 0 641364 FEW 1-10 0 641383 FEW 0 0 641400 FEW 0 0 Female, Group: VIII - 641234 641256 641282 641352 641356 641366 641377 641385 641387 641399 NONE. FEW NONE PEW MT FEW FEW NONE NONE PEW 1000 mg/kg - 0 0 1-10 1-10 NT 11-50 0 0 0 1-10 Day 124 0 0 0 0 MT 0 0 0 0 0 NCRY MICR FEW NONE NOME PEW FEW NONE FEW FEW FEW NONE MODERATE FEW FEW MODERATE FEW PEW FEW FEW PEW FEW NONE FEW FEW NONE NT NOME NONE FEW FEW NOME FEW FEW MODERATE PEW NT FEW PEW FEW MODERATE MODERATE SPER SPEC 0 0 0 Sample i 0 0 0 0 0 0 0 0 0 0 0 MT 0 1-MUCUS 0 1-MUCUS 0 0 0 BELOW RECOMMENDED 768 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX K INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS 769 ?Cft'"--"~ ---n ,,;qf H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL AMIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Group 0 mg/kg/day Sex :MALES ANIMAL FBW (Gms) BRAIN (Gms) %FBW ADRENAL GLANDS (Gms) %FBW %BRAIN EPIDIDYMIDES (Gms) %PBW %BRAIN (Gms) HEART %FBW %BRAIN 641069 641070 641094 641147 641149 641155 641172 641206 641214 641222 629.0 587.7 608.4 491.3 509.1 500.4 580.9 636.8 612.4 556.0 2.016 2.040 2.051 2.001 2.059 2.187 2.085 2.365 2.109 2.250 0.3205 0.3471 0.3371 0.4073 0.4044 0.4371 0.3589 0.3714 0.3444 0.4047 0.054 0.058 0.064 0.055 0.057 0.035 0.048 0.051 0.060 0.060 0.0086 0.0099 0.0105 0.0112 0.0112 0.0070 0.0083 0.0080 0.0098 0.0108 2.6786 2.8431 3.1204 2.7486 2.7683 1.6004 2.3022 2.1564 2.8450 2.6667 1.551 1.512 1.623 1.301 1.440 1.359 1.551 1.671 1.724 1.497 0.2466 0.2573 0.2668 0.2648 0.2829 0.2716 0.2670 0.2624 0.2815 0.2692 76.935 74.118 79.132 65.017 69.937 62.140 74.388 70.655 81.745 66.533 1.944 1.588 1.710 1.556 1.527 1.512 1.921 1.901 1.914 1.642 0.3091 0.2702 0.2811 0.3167 0.2999 0.3022 0-.3307 0.2985 0.3125 0.2953 96.429 77.843 83.374 77.761 74.162 69.136 92.134 80.381 90.754 72.978 Mean S.D. 571.2 54.3 2.116 0.3733 0.117 0.0380 0.054 0.0095 2.5730 0.008 0.0015 0.4382 1.523 0.2670 72.060 0.132 0.0107 6.3444 1.722 0.3016 81.495 0.180 0.0174 9.0249 (Gms) KIDNE %FBW 4.325 4.003 4.102 3.755 3.893 3.558 3.969 4.951 4.856 3.767 0.687 0.681 0.674 0.764 0.764 0.711 0.683 0.777 0.792 0.677 4.118 0.721 0.464 0.047 Group : III - 50 mg/kg/day Sex ANIMAL PBW (Gms) BRAIN (Gms-) %FBW :MALES ADRENAL GLANDS (Gms) %FBW %BRAIN 641055 641056 641073 641081 641144 641146 641178 641198 641218 641224 507.3 560.0 580.9 498.9 582.2 482.4 540.6 653.4 481.0 652.1 2.121 2.095 2.053 1.976 2.124 2.102 2.052 2.164 2.090 2.165 0.4181 0.3741 0.3534 0.3961 0.3648 0.4357 0.3796 0.3312 0.4345 0.3320 0.047 0.046 0.058 0.046 0.065 0.051 0.043 0.060 0.043 0.048 0.0093 0.0082 0.0100 0.0092 0.0112 0.0106 0.0080 0.0092 0.0089 0.0074 2.2159 2.1957 2.8251 2.3279 3.0603 2.4263 2.0955 2.7726 2.0574 2.2171 Mean S.D. 553.9 64.0 2.094 0.3820 0.057 0.0386 0.051 0.0092 2.4194 0.008 0.0012 0.3459 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.575 1.551 1.408 1.612 1.538 1.361 1.481 1.440 1.370 1.323 0.3105 0.2770 0.2424 0.3231 0.2642 0.2821 0.2740 0.2204 0.2848 0.2029 74.257 74.033 68.583 81.579 72.411 64.748 72.173 66.543 65.550 61.109 1.466 0.2681 70.099 0.1.00 0.0374 5.9564 (Gms) HEART %FBW %BRAIN 1.649 1.519 1.648 1.585 1.727 1.681 1.602 1.704 1.475 1.803 0.3251 0.2713 0.2837 0.3177 0.2966 0.3485 0.2963 0.2608 0.3067 0.2765 77.746 72.506 80.273 80.213 81.309 79.971 78.070 78.743 70.574 83.279 1.639 0.2983 78.268 0.098 0.0269 3.9157 (Gms) KIDNE %FBW 4.089 3.977 4.267 3.339 4.041 3.755 4.120 5.068 3.824 4.234 0.806 0.710 0.734 0.669 0.694 0.778 0.762 0.775 0.795 0.649 4.071 0.737 0.443 0.054 FBW - Final Body Weight 770 I l l'"'sty H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Group : V - 250 nig/kg/day INDIVIDUAL ANIMAL FINAL BODY AMD ORGAN WEIGHTS FOK MALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Sex :MALES ANIMAL FBW (Gins) BRAIN (Gms) %FBW ADRENAL GLANDS (Gms) %PBW %BRAIN EPIDIDYMIDES (Gms) %FBW %BRAIN (Gins) HEART %FBW %BRAIN 641061 641089 641102 641134 641137 641162 641190 641197 641200 641202 557.6 500.7 524.6 463.7 547.7 507.3 532.7 511.0 526.8 580.3 2.205 2.071 2.255 2.109 2.099 2.077 2.102 1.997 2.119 2.037 0.3954 0.4136 0.4299 0.4548 0.3832 0.4094 0.3946 0.3908 0.4022 0.3510 0.053 0.058 0.057 0.053 0.055 0.049 0.053 0.062 0.051 0.068 0.0095 0.0116 0.0109 0.0114 0.0100 0.0097 0.0099 0.0121 0.0097 0.0117 2.4036 2.8006 2.5277 2.5130 2.6203 2.3592 2.5214 3.1047 2.4068 3.3382 1.546 1.334 1.468 1.371 1.520 1.538 1.473 1.342 1.416 1.453 0.2773 0.2664 0.2798 0.2957 0.2775 0.3032 0.2765 0.2626 0.2688 0.2504 70.113 64.413 65.100 65.007 72.415 74.049 70.076 67.201 66.824 71.330 1.668 1.507 1.807 1.338 1.789 1.583 1.444 1.558 1.566 1.756 0.2991 0.3010 0.3445 0.2885 0.3266 0.3120 0.2711 0'.3049 0.2973 0.3026 75.646 72.767 80.133 63.442 85.231 76.216 68.696 78.017 73.903 86.205 Mean S.D. 525.2 32.6 2.107 0.4025 0.075 0.0277 0.056 0.0107 2.6596 0.006 0.0010 0.3262 1.446 0.2758 68.653 0.078 0.0154 3.3985 1.602 0.3048 76.026 0.154 0.0200 6.9647 (Gins) KIDNEY %PBW 4.594 3.803 4.608 3.829 4.549 4.370 4.488 4.020 4.274 4.432 0.8239 0.7595 0.8784 0.8257 0.8306 0.8614 0.8425 0.7867 0.8113 0.7637 4.297 0.8184 0.307 0.0391 Group : VII - 1000 mg/kg/day Sex :MALES ANIMAL FBW (Gms) [ BRAIN | (Gms") %FBW ADRENAL GLANDS (Gms) %PBW %BRAIN 641067 641077 641086 641095 641097 641132 641157 641166 641201 641223 426.5 499.5 464.6 422.6 462.1 490.9 420.2 456.2 446.9 445.9 1.882 2.110 2.093 2.070 2.010 2.161 2.055 2.290 2.062 2.144 0.4413 0.4224 0.4505 0.4898 0.4350 0.4402 0.4891 0.5020 0.4614 0.4808 0.037 0.053 0.046 0.045 0.034 0.057 0.048 0.053 0.038 0.043 0.0087 0.0106 0.0099 0.0106 0.0074 0.0116 0.0114 0.0116 0.0085 0.0096 1.9660 2.5118 2.1978 2.1739 1.6915 2.6377 2.3358 2.3144 1.8429 2.0056 Mean S.D. 453.5 27.1 2.088 0.4612 0.106 0.0275 0.045 0.0100 2.1677 0.008 0.0015 0.2961 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.287 1.529 1.450 1.344 1.336 1.479 1.427 1.612 1.656 1.310 0.3018 0.3061 0.3121 0.3180 0.2891 0.3013 0.3396 0.3534 0.3706 0.2938 68.385 72.464 69.279 64.928 66.468 68.441 69.440 70.393 80.310 61.101 1.443 0.3186 69.121 0.127 0.0271 5.0341 (Gms) HEART %FSW %BRAIN 1.272 1.531 1.430 1.330 1.375 1.652 1.281 1.427 1.765 1.456 0.2982 0.3065 0.3078 0.3147 0.2976 0.3365 0.3049 0.3128 0.3949 0.3265 67.588 72.559 68.323 64.251 68.408 76.446 62.336 62.314 85.597 67.910 1.452 0.3200 69.573 0.159 0.0290 7.1174 (Gms) KIDNEY %FBW 4.462 4.484 4.061 4.034 3.474 5.198 3.829 4.277 3.559 4.082 1.0462 0.8977 0.8741 0.9546 0.7518 1.0589 0.9112 0.9375 0.7964 0.9155 4.146 0.9144 0.501 0.0958 FBW - Final Body Weight 771 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Group ; I - 0 mg/kg/day Sex :MALES ANIMAL (Gms) LIVER %FBW %BRAIN (Gms) SPLEEN %FBW %BRAIN (Grns) TESTES %FBW %BRAIN (Gms) THYMUS %FBW %BRAIN 641069 641070 641094 641147 641149 641155 641172 641206 641214 641222 19.077 15.934 16.957 12.243 14.739 13.483 16.341 19.998 17.749 16.478 3.0329 2.7112 2.7871 2.4920 2.8951 2.6944 2.8130 3.1404 2.8983 2.9637 946.28 781.08 826.77 611.84 715.83 616.51 783.74 845.58 841.58 732.36 0.869 0.927 0.771 0.603 0.641 0.672 0.916 0.834 0.992 0.881 0.1382 0.1577 0.1267 0.1227 0.1259 0.1343 0.1577 0.1310 0.1620 0.1585 43.105 45.441 37.591 30.135 31.132 30.727 43.933 35.264 47.037 39.156 4.047 3.502 3.441 3.243 3.603 3.116 3.491 3.828 3.629 3.624 0.6434 0.5959 0.5656 0.6601 0.7077 0.6227 0.6010 0.6011 0.5926 0.6518 200.74 171.67 167.77 162.07 174.99 142.48 167.43 161.86 172.07 161.07 0.506 0.240 0.473 0.328 0.379 0.256 0.405 0.366 0.570 0.432 0.0804 0.0408 0.0777 0.0668 0.0744 0.0512 0.0697 0'.0575 0.0931 0.0777 25.099 11.765 23.062 16.392 18.407 11.706 19.424 15.476 27.027 19.200 Mean S.D. 16.300 2.8428 770.16 2.379 0.1860 104.55 0.811 0.1415 38.352 0.133 0.0157 6.3942 3.552 0.6242 168.22 0.266 0.0418 14.618 0.396 0.0689 18.756 0.105 0.0154 5.1950 Group : III - 50 mg/kg/day Sex :MALES ANIMAL (Gins) LIVER %FBW %BRAIN (Gins) SPLEEN %FBW %BRAIN 641055 641056 641073 641081 641144 641146 641178 641198 641218 641224 13.800 16.068 17.354 16.514 19.408 14.842 16.575 20.381 13.152 20.628 2.7203 2.8693 2.9874 3.3101 3.3336 3.0767 3.0660 3.1192 2.7343 3.1633 650.64 766.97 845.30 835.73 913.75 706.09 807.75 941.82 629.28 952.79 0.735 0.801 0.872 0.640 0.860 0.793 0.691 1.059 0.733 1.012 0.1449 0.1430 0.1501 0.1283 0.1477 0.1644 0.1278 0.1621 0.1524 0.1552 34.653 38.234 42.474 32.389 40.490 37.726 33.674 48.937 35.072 46.744 Mean S.D. 16.872 3.0380 805.01 2.611 0.2135 115.90 0.820 0.1476 39.039 0.135 0.0123 5.5936 (Gms) TESTES %FBW %BRAIN 3.708 3.430 3.595 3.153 3.667 3.327 3.383 3.914 3.291 2.957 0.7309 0.6125 0.6189 0.6320 0.6299 0.6897 0.6258 0.5990 0.6842 0.4535 174.82 163.72 175.11 159.56 172.65 158.28 164.86 180.87 157.46 136.58 3.443 0.6276 164.39 0.284 0.0739 12.676 (Gms) THYMUS %FBW %BRAIN 0.350 0.250 0.486 0.449 0.281 0.409 0.347 0.469 0.147 0.334 0.0690 0.0446 0.0837 0.0900 0.0483 0.0848 0.0642 0.0718 0.0306 0.0512 16.502 11.933 23.673 22.723 13.230 19.458 16.910 21.673 7.0335 15.427 0.352 0.0638 16.856 0.107 0.0197 5.2376 FBW - Final Body Weight 772 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AMD ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Group : V - 250 mg/kg/day Sex :MALES ANIMAL (Gas) LIVER %FBW %BRAIN (Gms) SPLEEN %FBW %BRAIN 641061 641089 641102 641134 641137 641162 641190 641197 641200 641202 18.631 16.441 17.634 14.968 19.214 16.548 16.051 16.081 17.127 19.062 3.3413 3.2836 3.3614 3.2279 3.5081 3.2620 3.0131 3.1470 3.2511 3.2849 844.94 793.87 782.00 709.72 915.39 796.73 763.61 805.26 808.26 935.79 0.741 0.723 0.803 0.790 0.712 0.708 0.778 0.752 0.701 0.806 0.1329 0.1444 0.1531 0.1704 0.1300 0.1396 0.1460 0.1472 0.1331 0.1389 33.605 34.911 35.610 37.459 33.921 34.088 37.012 37.656 33.082 39.568 Mean S.D. 17.176 3.2680 815.56 1.427 0.1307 67.738 0.751 0.1435 35.691 0.040 0.0119 2.1407 (Gms) TESTES %FBW %BRAIN 3.171 3.490 3.749 3.118 3.766 3.490 3.465 3.405 3.625 3.463 0.5687 0.6970 0.7146 0.6724 0.6876 0.6880 0.6505 0.6663 0.6881 0.5968 143.81 168.52 166.25 147.84 179.42 168.03 164.84 170.51 171.07 170.00 3.474 0.6630 165.03 0.213 0.0462 10.887 (Gms) THYMUS %FBW %BRAIN 0.409 0.282 0.418 0.399 0.238 0.264 0.324 0.381 0.452 0.423 0.0734 0.0563 0.0797 0.0860 0.0435 0.0520 0.0608 0.0746 0.0858 0.0729 18.549 13.617 18.537 18.919 11.339 12.711 15.414 19.079 21.331 20.766 0.359 0.0685 17.026 0.076 0.0146 3.4977 Group : VII - 1000 mg/kg/day Sex :MALES ANIMAL (Gms) LIVER %FBW %BRAIN (Gms) SPLEEN %FBW %BRAIN 641067 641077 641086 641095 641097 641132 641157 641166 641201 641223 14.947 3.5046 794.21 0.548 0.1285 29.118 19.083 3.8204 904.41 0.636 0.1273 30.142 17.103 3.6812 817.15 0.786 0.1692 37.554 17.741 4.1981 857.05 0.632 0.1496 30.531 17.631 3.8154 877.16 0.589 0.1275 29.303 21.326 4.3443 986.86 0.640 0.1304 29.616 16.209 3..8574 788.76 0.564 0.1342 27.445 18.115 3.9708 791.05 0.639 0.1401 27.904 17.184 3.8452 833.37 0.600 0.1343 29.098 18.047 4.0473 841.74 0.596 0.1337 27.799 Mean S.D. 17.739 3.9085 849.18 1.692 0.2438 61.674 0.623 0.1375 29.851 0.066 0.0130 2.8893 (Gms) TESTES %FBW %BRAIN 3.089 3.981 3.236 3.448 3.366 3.808 3.609 3.801 3.351 4.686 0.7243 0.7970 0.6965 0.8159 0.7284 0.7757 0.8589 0.8332 0.7498 1.0509 164.13 188.67 154.61 166.57 167.46 176.21 175.62 165.98 162.51 218.56 3.638 0.8031 174.03 0.463 0.1013 18.185 (Gms) THYMUS %FBW %BRAIN 0.265 0.420 0.330 0.355 0.188 0.386 0.185 0.263 0.320 0.195 0.0621 0.0841 0.0710 0.0840 0.0407 0.0786 0.0440 0.0577 0.0716 0.0437 14.081 19.905 15.767 17.150 9.3532 17.862 9.0024 11.485 15.519 9.0951 0.291 0.0638 13.922 0.085 0.0167 3.9726 FBW - Final Body Weight 773 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AMD ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR ONE-MONTH RECOVERY EVALUATION Group ANIMAL 0 mg/kg/day Sex :MALES PBW (Gms) BRAIN (Gms) %PBW ADRENAL GLANDS (Gms) %PBW %BRAIN EPIDIDYMIDES (Gms) %FBW %BRAIN (Gms) HEART %PBW %BRAIN 641083 641084 641085 641101 641105 641123 641154 641159 641165 641215 Mean S.D. 644.7 558.2 603.3 623.2 653.2 593.8 660.0 618.6 590.9 596.4 614.2 31.9 2.088 2.131 2.233 2.273 2.195 2.298 2.157 2.360 2.256 2.178 0.3239 0.3818 0.3701 0.3647 0.3360 0.3870 0.3268 0.3815 0.3818 0.3652 2.217 0.3619 0.083 0.0241 0.052 0.041 0.060 0.053 0.059 0.065 0.054 0.058 0.064 0.044 0.0081 0.0073 0.0099 0.0085 0.0090 0.0109 0.0082 0.0094 0.0108 0.0074 2.4904 1.9240 2.6870 2.3317 2.6879 2.8285 2.5035 2.4576 2.8369 2.0202 0.055 0.0090 2.4768 0.008 0.0013 0.3124 1.631 1.514 1.424 1.429 1.681 1.433 1.737 1.669 1.563 1.531 0.2530 0.2712 0.2360 0.2293 0.2573 0.2413 0.2632 0.2698 0.2645 0.2567 78.113 71.046 63.771 62.868 76.583 62.359 80.529 70.720 69.282 70.294 1.561 0.2542 70.557 0.114 0.0144 6.3873 2.018 1.506 1.585 1.721 1.879 1.903 1.983 1.871 1.777 1.743 0.3130 0.2698 0.2627 0.2762 0.2877 0.3205 0.3005 0'.3025 0.3007 0.2923 96.647 70.671 70.981 75.715 85.604 82.811 91.933 79.280 78.768 80.028 1.799 0.2926 81.244 0.165 0.0186 8.3809 (Gms) KIDMEY %FBW 4.533 3.453 4.097 4.394 5.067 4.400 4.823 4.748 4.918 4.112 0.7031 0.6186 0.6791 0.7051 0.7757 0.7410 0.7308 0.7675 0.8323 0.6895 4.455 0.7243 0.480 0.0594 Sroup : VI[I - 100C3 ing/kg/day Sext ; MALES ANIMAL FBW (Gins) BRAIN (Gms) %PBW ADRENAL GLANDS (Gms) %FBW %BRAIN 641064 641092 641143 641153 641167 641185 641189 641203 641213 641216 550.0 686.9 614.1 459.1 591.5 564.2 509.5 518.5 699.0 567.1 2.333 2.195 2.235 1.875 1.979 2.215 2.088 2.123 2.214 1.994 0.4242 0.3196 0.3639 0.4084 0.3346 0.3926 0.4098 0.4095 0.3167 0.3516 0.051 0.066 0.063 0.049 0.069 0.037 0.058 0.049 0.052 0.063 0.0093 0.0096 0.0103 0.0107 0.0117 0.0066 0.0114 0.0095 0.0074 0.0111 2.1860 3.0068 2.8188 2.6133 3.4866 1.6704 2.7778 2.3081 2.3487 3.1595 Mean S.D. 576.0 75.6 2.125 0.3731 0.141 0.0408 0.056 0.0097 2.6376 0.010 0.0017 0.5285 EPIDIDYMIDES (Gms) %PBW %BRAIN 1.578 1.573 1.662 1.263 1.559 1.601 1.447 1.355 1.624 1.690 0.2869 0.2290 0.2706 0.2751 0.2636 0.2838 0.2840 0.2613 0.2323 0.2980 67.638 71.663 74.362 67.360 78.777 72.280 69.301 63.825 73.351 84.754 1.535 0.2685 72.331 0.138 0.0228 6.0533 (Gms) HEART %FBW %BRAIN 1.930 1.844 1.911 1.354 1.756 1.720 1.522 1.661 1.770 1.703 0.3509 0.2685 0.3112 0.2949 0.2969 0.3049 0.2987 0.3203 0.2532 0.3003 82.726 84.009 85.503 72.213 88.732 77.652 72.893 78.238 79.946 85.406 1.717 0.3000 80.732 0.175 0.0266 5.5143 (Gms) KIDNEY %FBW 4.607 4.821 4.630 3.257 4.731 4.320 3.548 4.538 5.027 4.203 0.8376 0.7018 0.7539 0.7094 0.7998 0.7657 0.6964 0.8752 0.7192 0.7411 4.368 0.7600 0.564 0.0605 FBW - Final Body Weight 774 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR ONE-MONTH RECOVERY EVALUATION Group ANIMAL 0 ing/kg/day Sex :MALES (Gins) LIVER %FBW %BRAIN (Gms) SPLEEN %FBW %BRAIN (Gms) TESTES %PBW %BRAIN (Gins) THYMUS %FBW %BRAIN 641083 641084 641085 641101 641105 641123 641154 641159 641165 641215 Mean S.D. 19.948 15.928 16.759 20.194 17.134 18.244 19.196 18.122 16.473 18.829 3.0942 2.8535 2.7779 3.2404 2.6231 3.0724 2.9085 2.9295 2.7878 3.1571 955.36 747.44 750.52 888.43 780.59 793.91 889.94 767.88 730.19 864.51 18.083 2.9444 816.88 1.477 0.1935 76.660 0.828 0.804 0.926 0.762 0.836 0.838 0.922 1.066 0.750 0.785 0.1284 0.1440 0.1535 0.1223 0.1280 0.1411 0.1397 0.1723 0.1269 0.1316 39.655 37.729 41.469 33.524 38.087 36.466 42.745 45.169 33.245 36.042 0.852 0.1388 38.413 0.096 0.0151 3.8858 3.351 3.560 3.430 3.269 3.659 3.315 3.670 3.646 3.659 3.472 0.5198 0.6378 0.5685 0.5246 0.5602 0.5583 0.5561 0.5894 0.6192 0.5822 160.49 167.06 153.61 143.82 166.70 144.26 170.14 154.49 162.19 159.41 3.503 0.5716 158.22 0.156 0.0373 9.1412 0.331 0.313 0.483 0.318 0.533 0.327 0.494 0.407 0.483 0.385 0.0513 0.0561 0.0801 0.0510 0.0816 0.0551 0..0748 0.0658 0.0817 0.0646 15.852 14.688 21.630 13.990 24.282 14.230 22.902 17.246 21.410 17.677 0.407 0.0662 18.391 0.085 0.0126 3.8489 Group : VII - 1000 mg/kg/day Sex :MALES ANIMAL (GTOS) LIVER %FBW. %BRAIN (Gas) SPLEEN %FBW %BRAIN 641064 641092 641143 641153 641167 641185 641189 641203 641213 641216 20.890 25.042 22.698 16.643 21.267 21.082 18.525 18.644 29.117 22.186 3.7982 3.6457 3.6961 3.6251 3.5954 3.7366 3.6359 3.5958 4.1655 3.9122 895.41 1140.9 1015.6 887.63 1074.6 951.78 887.21 878.19 1315.1 1112.6 0.684 0.880 0.754 0.714 0.905 0.716 0.824 0.724 0.730 0.785 0.1244 0.1281 0.1228 0.1555 0.1530 0.1269 0.1617 0.1396 0.1044 0.1384 29.318 40.091 33.736 38.080 45.730 32.325 39.464 34.103 32.972 39.368 Mean S.D. 21.609 3.7407 1015.9 3.552 0.1797 144.75 0.772 0.1355 36.519 0.075 0.0176 4.8583 (Gms) TESTES %FBW %BRAIN 3.799 3.725 4.179 3.085 3.809 3.953 3.294 3.424 3.255 3.718 0.6907 0.5423 0.6805 0.6720 0.6440 0.7006 0.6465 0.6604 0.4657 0.6556 162.84 169.70 186.98 164.53 192.47 178.47 157.76 161.28 147.02 186.46 3.624 0.6358 170.75 0.346 0.0741 14.778 (Gms) THYMUS %PBW %BRAIN 0.298 0.440 0.407 0.248 0.352 0.379 0.262 0.330 0.323 0.327 0.0542 0.0641 0.0663 0.0540 0.0595 0.0672 0.0514 0.0636 0.0462 0.0577 12.773 20.046 18.210 13.227 17.787 17.111 12.548 15.544 14.589 16.399 0.337 0.0584 15.823 0.060 0.0069 2.5330 FBW - Final Body Weight 775 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AMD ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 3-MONTH RECOVERY EVALUATION Group : I - 0 ing/kg/day Sex :MALES | ANIMAL FBW LIVER | (Gms) (Gms) %PBW | 641066 641098 641104 641115 641220 470.9 517.0 586.9 764.5 515.4 13.329 15.218 15.426 22.263 13.908 2.8305 2.9435 2.6284 2.9121 2.6985 Mean S.D. 570.9 115.9 16.029 2.8026 3.594 0.1358 Group : III - 50 | ANIMAL FBW (Gins) ing/kg/day Sex (Gms) LIVER %FBW :MALES 641059 641113 641160 641194 641225 521.8 747.9 565.5 571.6 660.5 13.529 27.573 14.528 15.399 18.422 2.5928 3.6867 2.5691 2.6940 2.7891 Mean S.D. 613.5 90.5 17.890 2.8663 5.713 0.4669 FBW - Final Body Weight 776 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL AMIMAL FINAL BODY AMD ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 3-MONTH RECOVERY EVALUATION Group : V - 250 nig/kg/day Sex :MALES ANIMAL FBW (Gins) (Gms) LIVER %FBW 641076 641141 641148 641187 517.5 643.2 633.3 665.2 14.117 19.383 17.474 20.263 2.7279 3.0135 2.7592 3.0462 Mean S.D. 614.8 66.2 17.809 2.8867 2.723 0.1663 3roup : VII - 1000 mg/kg /day Sex :MALES AMIMAL FBW | LIVER 1 (Gms) |(Gms) %FBW 641057 641130 641169 641196 641205 524.7 514.4 640.5 645.3 816.8 14.650 17.965 21.224 17.996 27.635 2.7921 3.4924 3.3137 2.7888 3.3833 Mean S.D. 628.3 122.1 19.894 3.1541 4.912 0.3380 FBW - Final Body Weight 777 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Group : II ANIMAL 0 nig/kg/day Sex : FEMALES FBW (Gms) BRAIN (Gins) %PBW ADRENAL GLANDS (Gms) %PBW %BRAIN (Gins) HEART %FBW' %BRAIN (Gins) KIDNEYS %FBW %BRAIN 641240 641245 641257 641283 641290 641293 641335 641344 641384 349.9 290.4 289.2 318.6 367.6 303.7 290.7 280.8 286.9 1.986 1.981 1.944 1.958 1.893 2.027 1.902 1.940 1.967 0.5676 0.6822 0.6722 0.6146 0.5150 0.6674 0.6543 0.6909 0.6856 0.090 0.084 0.073 0.076 0.059 0.044 0.057 0.066 0.059 0.0257 0.0289 0.0252 0.0239 0.0161 0.0145 0.0196 0.0235 0.0206 4.5317 4.2403 3.7551 3.8815 3.1167 2.1707 2.9968 3.4021 2.9995 1.279 1.043 0.985 1.255 1.285 1.178 1.060 1.071 1.056 0.3655 0.3592 0.3406 0.3939 0.3496 0.3879 0.3646 0.3814 0.3681 64.401 52.650 50.669 64.096 67.882 58.115 55.731 55.206 53.686 2.382 2.446 2.303 2.461 2.504 2.104 2.211 2.276 2.207 0.6808 0.8423 0.7963 0.7724 0.6812 0.6928 0.7606 0'.8105 0.7693 119.94 123.47 118.47 125.69 132.28 103.80 116.25 117.32 112.20 Mean S.D. 308.6 30.8 1.955 0.6389 0.042 0.0612 0.068 0.0220 3.4549 0.015 0.0047 0.7273 1.135 0.3679 58.048 0.115 0.0174 6.0177 2.322 0.7562 118.82 0.136 0.0589 8.1365 (Gms) LIVER %FBW 8.865 8.603 8.166 9.501 10.766 8.493 8.708 8.890 7.647 2.533 2.9625 2.8237 2.9821 2.928 2.7965 2.9955 3.1660 2.6654 8.849 2.8727 0.882 0.190 Group IV 50 mg/kg/day Sex :FEMALES ANIMAL FBW (Gms) BRAIN (Gms) %PBW ADRENAL GLANDS (Gms) %PBW %BRAIN 641260 641298 641311 641312 641313 641336 641355 641361 641369 641396 Mean S.D. 306.0 320.3 311.6 281.1 300.5 289.8 276.0 309.7 266.8 283.3 294.5 17.6 1.952 0.6379 1.964 0.6132 1.813 0.5818 2.022 0.7193 1.922 0.6396 ' 1.949 0.6725 1.921 0.6960 1.899 0.6132 1.924 0.7211 2.006 0.7081 1.937 0.6603 0.058 0.0499 0.087 0.066 0.066 0.082 0.061 0.063 0.055 0.080 0.066 0.077 0.0284 0.0206 0.0212 0.0292 0.0203 0.0217 0.0199 0.0258 0.0247 0.0272 4.4570 3.3605 3.6404 4.0554 3.1738 3.2324 2.8631 4.2127 3.4304 3.8385 0.070 0.0239 3.6264 0.010 0.0036 0.5071 (Gms) HEART %FBW %BRAIN 0.958 1.151 1.015 1.223 1.073 0.975 0.962 1.022 0.934 1.028 0.3131 0.3594 0.3257 0.4372 0.3571 0.3364 0.3486 0.3300 0.3501 0.3629 49.078 58.605 55.985 60.781 55.827 50.026 50.078 53.818 48.545 51.246 1.035 0.3520 53.399 0.093 0.0340 4.2640 (Gins) KIDNEYS %FBW %BRAIN 2.207 2.579 2.349 2.512 2.226 2.503 2.376 2.498 2.218 2.321 0.7212 0.8052 0.7539 0.8936 0.7408 0.8637 0.8609 0.8066 0.8313 0.8193 113.06 131.31 129.56 124.23 115.82 128.42 123.69 131.54 115.28 115.70 2.379 0.8096 122.86 0.138 0.0566 7.2998 (Gms) LIVER %FBW 9.175 9.045 8.361 8.851 8.033 8.723 9.188 8.732 8.429 8.482 2.998 2.823 2.683 3.148 2.6732 3.010 3.329 2.819 3.1593 2.994 8.702 2.963 0.378 0.214 FBW - Final Body Weight 778 SBr H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AMD ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Group : VI - 250 mg/kg/day Sex :FEMALES ANIMAL FBW (Gms) BRAIN (Gins) %FBW ADRENAL GLANDS (GffiS) %FBW %BRAIN 641244 641251 641269 641292 641302 641362 641363 641375 641379 641398 295.5 265.9 265.9 331.1 300.4 284.6 387.9 355.6 320.1 306.3 1.945 1.875 1.923 1.977 1.991 1.974 2.042 1.951 1.895 1.915 0.6582 0.7052 0.7232 0.5971 0.6628 0.6936 0.5264 0.5487 0.5920 0.6252 0.059 0.063 0.084 0.059 0.099 0.082 0.121 0.069 0.086 0.057 0.0200 0.0237 0.0316 0.0178 0.0330 0.0288 0.0312 0.0194 0.0269 0.0186 3.0334 3.3600 4.3682 2.9843 4.9724 4.1540 5.9256 3.5366 4.5383 2.9765 Mean S.D. 311.3 38.8 1.949 0.6332 0.050 0.0667 0.078 0.0251 3.9849 0.021 0.0059 0.9853 (Gms) HEART %FBW %BRAIN 1.117 0.938 0.912 1.137 1.035 0.957 1.272 1.222 1.098 1.147 0.3780 0.3528 0.3430 0.3434 0.3445 0.3363 0.3279 0.3436 0.3430 0.3745 57.429 50.027 47.426 57.511 51.984 48.480 62.292 62.635 57.942 59.896 1.084 0.3487 55.562 0.121 0.0159 5.6454 (Gms) KIDNEYS %FBW %BRAIM 2.170 2.337 2.239 2.275 2.473 2.237 3.092 2.818 2.614 2.072 0.7343 0.8789 0.8420 0.6871 0.8232 0.7860 0.7971 0.7925 0-8166 0.6765 111.57 124.64 116.43 115.07 124.21 113.32 151.42 144.44 137.94 108.20 2.433 0.7834 124.72 0.321 0.0655 14.961 (Gms) LIVER %FBW 7.867 8.086 7.990 9.682 8.530 8.401 12.955 9.852 9.797 8.161 2.6623 3.0410 3.0049 2.9242 2.8395 2.9519 3.3398 2.7705 3.0606 2.6644 9.132 2.9259 1.553 0.2052 Sroup : VIII - 1000 mg/kg/day ANIMAL | FBW (Gms) " BRAIN (Gms) %FBW 641237 641275 641279 641299 641300 641314 641326 641327 641380 641390 235.7 253.3 348.5 244.2 297.9 313.7 253.0 371.2 300.7 318.0 1.802 1.949 1.870 1.853 2.222 1.945 1.928 1.919 1.974 1.949 0.7645 0.7694 0.5366 0.7588 0.7459 0.6200 0.7621 0.5170 0.6565 0.6129 Mean S.D. 293.6 46.2 1.941 0.6744 0.112 0.0988 Sex :FEMALES ADRENAL GLANDS (Gms) %FBW %BRAIN 0.066 0.076 0.055 0.079 0.069 0.080 0.079 0.083 0.080 0.071 0.0280 0.0300 0.0158 0.0324 0.0232 0.0255 0.0312 0.0224 0.0266 0.0223 3.6626 3.8994 2.9412 4.2634 3.1053 4.1131 4.0975 4.3252 4.0527 3.6429 0.074 0.0257 3.8103 0.009 0.0050 0.4730 (Gms) HEART %FBW %BRAIN | (Gms) KIDNEYS %FBW %BRAIN | (Gms) LIVER %FBW 1.024 0.979 1.143 0.843 1.058 1.093 0.880 1.393 1.101 1.047 0.4345 0.3865 0.3280 0.3452 0.3552 0.3484 0.3478 0.3753 0.3661 0.3292 56.826 50.231 61.123 45.494 47.615 56.195 45.643 72.590 55.775 53.720 2.516 2.075 2.573 2.201 2.472 2.528 2.164 2.721 2.498 2.383 1.0675 0.8192 0.7383 0.9013 0.8298 0.8059 0.8553 0.7330 0.8307 0.7494 139.62 106.46 137.59 118.78 111.25 129.97 112.24 141.79 126.55 122.27 8.288 8.063 10.645 8.620 9.026 9.742 8.273 12.673 10.323 10.461 3.5163 3.1832 3.0545 3.5299 3.0299 3.1055 3.2700 3.4141 3.4330 3.2896 1.056 0.3616 54.521 0.152 0.0316 8.2112 2.413 0.8330 124.65 0.205 0.0983 12.569 9.611 3.2826 1.451 0.1865 FBW Final Body Weight 779 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AMD ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Group : II - 0 nig/kg/day Sex ANIMAL (Gins) OVARIES %FBW %BRAIN : FEMALES (Gms) SPLEEN %FBW %BRAIN (Gms) THYMUS %FBW %BRAIN (Gms) UTERUS %FBW %BRAIN 641240 641245 641257 641283 641290 641293 641335 641344 641384 Mean S.D. 0.123 0.136 0.135 0.197 0.158 0.105 0.107 0.147 0.102 0.0352 0.0468 0.0467 0.0618 0.0430 0.0346 0.0368 0.0524 0.0356 6.1934 6.8652 6.9444 10.061 8.3465 5.1801 5.6257 7.5773 5.1856 0.134 0.0436 6.8866 0.030 0.0093 1.6034 0.564 0.493 0.428 0.503 0.515 0.423 0.408 0.560 0.420 0.1612 0.1698 0.1480 0.1579 0.1401 0.1393 0.1404 0.1994 0.1464 28.399 24.886 22.016 25.689 27.205 20.868 21.451 28.866 21.352 0.479 0.1558 24.526 0.061 0.0195 3.1957 0.353 0.289 0.287 0.179 0.379 0.327 0.349 0.339 0.271 0.1009 0.0995 0.0992 0.0562 0.1031 0.1077 0.1201 0.1207 0.0945 17.774 14.589 14.763 9.1420 20.021 16.132 18.349 17.474 13.777 0.308 0.1002 15.780 0.060 0.0189 3.2033 0.622 0.435 0.502 0.622 0.479 0.397 0.463 0.416 0.461 0.1778 0.1498 0.1736 0.1952 0.1303 0.1307 0.1593 0.1481 0.1607 31.319 21.959 25.823 31.767 25.304 19.586 24.343 21.443 23.437 0.489 0.1584 24.998 0.082 0.0215 4.1921 Group : IV - 50 ing/kg/day Sex : FEMALES ANIMAL (Gms) OVARIES %FBW %BRAIN (Gms) SPLEEN %FBW %BRAIN | (Gms) THYMUS %FBW %BRAIN 641260 641298 641311 641312 641313 641336 641355 641361 641369 641396 0.127 0.096 0.132 0.158 0.141 0.114 0.120 0.129 0.147 0.074 0.0415 0.0300 0.0424 0.0562 0.0469 0.0393 0.0435 0.0417 0.0551 0.0261 6.5061 4.8880 7.2808 7.8140 7.3361 5.8492 6.2467 6.7930 7.6403 3.6889 0.612 0.575 0.498 0.553 0.526 0.453 0.476 0.375 0.620 0.432 0.2000 0.1795 0.1598 0.1967 0.1750 0.1563 0.1725 0.1211 0.2324 0.1525 31.352 29.277 27.468 27.349 27.367 23.243 24.779 19.747 32.225 21.535 0.290 0.303 0.226 0.307 0.288 0.309 0.206 0.382 0.292 0.179 0.0948 0.0946 0.0725 0.1092 0.0958 0.1066 0.0746 0.1233 0.1094 0.0632 14.857 15.428 12.466 15.183 14.984 15.854 10.724 20.116 15.177 8.9232 Mean S.D. 0.124 0.0423 6.4043 0.025 0.0094 1.3046 0.512 0.1746 26.434 0.080 0.0306 4.0854 0.278 0.0944 14.371 0.059 0.0191 3.0705 (Gms) UTERUS %FBW %BRAIN 0.660 0.817 0.571 0.672 0.818 0.445 0.406 0.487 0.617 0.732 0.2157 0.2551 0.1832 0.2391 0.2722 0.1536 0.1471 0.1572 0.2313 0.2584 33.811 41.599 31.495 33.234 42.560 22.832 21.135 25.645 32.069 36.491 0.623 0.2113 32.087 0.146 0.0474 7.2364 FBW - Final Body Weight 780 ^vsy H-24616: Subchronic Toxicity 90-Day Gavage Study in Ratswith One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Group : VI - 250 ing/kg/day Sex :FEMALES ANIMAL (Gms) OVARIES %FBW %BRAIN (Gms) SPLEEN %FBW %BRAIN 641244 641251 641269 641292 641302 641362 641363 641375 641379 641398 0.099 0.097 0.090 0.133 0.147 0.130 0.101 0.114 0.123 0.121 0.0335 0.0365 0.0338 0.0402 0.0489 0.0457 0.0260 0.0321 0.0384 0.0395 5.0900 5.1733 4.6802 6.7274 7.3832 6.5856 4.9461 5.8432 6.4908 6.3185 0.529 0.445 0.529 0.581 0.548 0.506 0.651 0.682 0.428 0.580 0.1790 0.1674 0.1989 0.1755 0.1824 0.1778 0.1678 0.1918 0.1337 0.1894 27.198 23.733 27.509 29.388 27.524 25.633 31.881 34.956 22.586 30.287 Mean S.D. 0.116 0.0375 5.9238 0.018 0.0067 0.9103 0.548 0.1764 28.070 0.080 0.0181 3.7237 (Gms) THYMUS %FBW %BRAIN 0.258 0.238 0.274 0.306 0.357 0.255 0.444 0.472 0.339 0.267 0.0873 0.0895 0.1030 0.0924 0.1188 0.0896 0.1145 0.1327 0.1059 0.0872 13.265 12.693 14.249 15.478 17.931 12.918 21.743 24.193 17.889 13.943 0.321 0.1021 16.430 0.082 0.0158 3.9587 (Gins) UTERUS %PBW %BRAIN 0.583 0.816 0.604 0.462 0.754 0.597 0.727 0.641 0.706 0.602 0.1973 0.3069 0.2272 0.1395 0.2510 0..2098 0.1874 0.1803 0.2206 0.1965 29.974 43.520 31.409 23.369 37.870 30.243 35.602 32.855 37.256 31.436 0.649 0.2116 33.354 0.103 0.0449 5.5029 Group : VIII - 1000 nig/kg/day ANIMAL (Gms) OVARIES %FBW %BRAIN 641237 641275 641279 641299 641300 641314 641326 641327 641380 641390 0.069 0.128 0.121 0.130 0.141 0.113 0.105 0.149 0.146 0.147 0.0293 0.0505 0.0347 0.0532 0.0473 0.0360 0..0415 0.0401 0.0486 0.0462 3.8291 6.5675 6.4706 7.0156 6.3456 5.8098 5.4461 7.7645 7.3961 7.5423 Mean S.D. 0.125 0.0428 6.4187 0.025 0.0077 1.1756 Sex : FEMALES (Gms) SPLEEN %FBW %BRAIN | (Gms) THYMUS %FBW %BRAIN 0.494 0.379 0.569 0.450 0.761 0.651 0.465 0.615 0.470 0.581 0.2096 0.1496 0.1633 0.1843 0.2555 0.2075 0.1838 0.1657 0.1563 0.1827 27.414 19.446 30.428 24.285 34.248 33.470 24.118 32.048 23.810 29.810 0.264 0.286 0.477 0.334 0.396 0.305 0.233 0.395 0.260 0.250. 0.1120 0.1129 0.1369 0.1368 0.1329 0.0972 0.0921 0.1064 0.0865 0.0786 14.650 14.674 25.508 18.025 17.822 15.681 12.085 20.584 13.171 12.827 0.544 0.1858 27.908 0.113 0.0316 4.8806 0.320 0.1092 16.503 0.079 0.0211 4.1282 (Gins) UTERUS %FBW %BRAIN 0.670 0.992 0.419 0.738 0.510 0.521 0.473 0.697 0.618 0.550 0.2843 0.3916 0.1202 0.3022 0.1712 0.1661 0.1870 0.1878 0.2055 0.1730 37.181 50.898 22.406 39.827 22.952 26.787 24.533 36.321 31.307 28.220 0.619 0.2189 32.043 0.167 0.0817 9.0400 FBW - Final Body Weight 781 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AMD ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR ONE-MONTH RECOVERY EVALUATION Group : II ANIMAL 0 nig/kg/day Sex FBW (Gms) BRAIN (Gms) %PBW : FEMALES ADRENAL GLANDS (Gms) %FBW %BRAIN (Gms) HEART %FBW %BRAIN (Gms) KIDNEYS %FBW %BRAIN 641253 641266 641281 641294 641325 641331 641359 641364 641383 641400 Mean S.D. 389.7 336.6 293.3 336.0 314.2 311.1 309.5 322.6 295.5 290.4 319.9 29.5 1.977 1.842 1.906 2.037 1.918 1.850 1.864 1.942 2.019 1.915 0.5073 0.5472 0.6498 0.6062 0.6104 0.5947 0.6023 0.6020 0.6832 0.6594 1.927 0.6063 0.068 0.0518 0.065 0.058 0.077 0.086 0.067 0.058 0.058 0.072 0.070 0.061 0.0167 0.0172 0.0263 0.0256 0.0213 0.0186 0.0187 0.0223 0.0237 0.0210 3.2878 3.1488 4.0399 4.2219 3.4932 3.1351 3.1116 3.7075 3.4671 3.1854 0.067 0.0211 3.4798 0.009 0.0034 0.3950 1.251 1.169 1.096 1.277 1.309 1.329 0.987 1.123 1.260 1.012 0.3210 0.3473 0.3737 0.3801 0.4166 0.4272 0.3189 0.3481 0.4264 0.3485 63.278 63.464 57.503 62.690 68.248 71.838 52.951 57.827 62.407 52.846 1.181 0.3708 61.305 0.123 0.0411 6.1350 2.730 2.419 2.515 2.541 2.488 2.486 2.463 2.337 2.692 2.295 0.7005 0.7187 0.8575 0.7562 0.7919 0.7991 0.7958 0.7244 0.9110 0.7903 138.09 131.32 131.95 124.74 129.72 134.38 132.14 120.34 133.33 119.84 2.497 0.7845 129.59 0.137 0.0646 6.0397 (Gms) LIVER %FBW 9.714 10.148 9.356 10.798 9.967 7.274 8.587 9.869 9.307 7.817 2.4927 3.0149 3.1899 3.2137 3.1722 2.3382 2.7745 3.0592 3.1496 2.6918 9.284 2.9097 1.091 0.3157 3roup : VIII - 1000 ing/kg/day ANIMAL | FBW | (Gms) BRAIN (Gms) %PBW 641234 641256 641282 641352 641366 641377 641385 641387 641399 301.3 288.1 414.9 303.5 310.1 293.4 320.5 301.2 342.2 1.792 1.873 1.968 2.028 1.987 1.890 1.819 1.904 1.902 0.5948 0.6501 0.4743 0.6682 0.6408 0.6442 0.5676 0.6321 0.5558 Mean S.D. 319.5 39.2 1.907 0.6031 0.077 0.0618 Sex :FEMALES ADRENAL GLANDS | (Gms) %FBW %BRAIN | (Gms) HEART %FBW %BRAIN 0.088 0.062 0.092 0.068 0.076 0.077 0.064 0.060 0.082 0.0292 0.0215 0.0222 0.0224 0.0245 0.0262 0.0200 0.0199 0.0240 4.9107 3.3102 4.6748 3.3531 3.8249 4.0741 3.5184 3.1513 4.3113 0.074 0.0233 3.9032 0.012 0.0030 0.6305 1.110 1.101 1.317 1.151 1.205 1.109 1.142 1.148 1.212 0.3684 0.3822 0.3174 0.3792 0.3886 0.3780 0.3563 0.3811 0.3542 61.942 58.783 66.921 56.755 60.644 58.677 62.782 60.294 63.722 1.166 0.3673 61.169 0.069 0.0221 3.0664 (Gms) KIDNEYS %FBW %BRAIM 2.375 2.369 2.863 2.194 2.885 2.447 2.387 2.227 2.702 0.7883 0.8223 0.6900 0.7229 0.9303 0.8340 0.7448 0.7394 0.7896 132.53 126.48 145.48 108.19 145.19 129.47 131.23 116.96 142.06 2.494 0.7846 130.84 0.259 0.0720 12.629 (Gms) LIVER %FBW 9.403 9.379 12.117 9.306 10.726 8.708 9.682 9.137 9.895 3.1208 3.2555 2.9205 3.0662 3.4589 2.9680 3.0209 3.0335 2.8916 9.817 3.0818 1.028 0.1786 FBW - Final Body Weight 782 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AMD ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR ONE-MONTH RECOVERY EVALUATION Group : II - 0 mg/kg/day Sex ANIMAL (Gins) OVARIES %FBW %BRAIN :FEMALES (Gms) SPLEEN %FBW %BRAIN (Gins) THYMUS %FBW %BRAIN (Gms) UTERUS %FBW %BRAIN 641253 641266 641281 641294 641325 641331 641359 641364 641383 641400 Mean S.D. 0.141 0.133 0.110 0.127 0.100 0.085 0.097 0.126 0.093 0.126 0.0362 0.0395 0.0375 0.0378 0.0318 0.0273 0.0313 0.0391 0.0315 0.0434 7.1320 7.2204 5.7712 6.2347 5.2138 4.5946 5.2039 6.4882 4.6062 6.5796 0.114 0.0355 5.9045 0.019 0.0049 0.9736 0.570 0.540 0.503 0.555 0.557 0.489 0.404 0.613 0.602 0.516 0.1463 0.1604 0.1715 0.1652 0.1773 0.1572 0.1305 0.1900 0.2037 0.1777 28.832 29.316 26.390 27.246 29.041 26.432 21.674 31.565 29.817 26.945 0.535 0.1680 27.726 0.061 0.0211 2.6981 0.280 0.292 0.219 0.382 0.330 0.211 0.273 0.306 0.162 0.249 0.0719 0.0867 0.0747 0.1137 0.1050 0.0678 0.0882 0.0949 0.0548 0.0857 14.163 15.852 11.490 18.753 17.205 11.405 14.646 15.757 8.0238 13.003 0.270 0.0843 14.030 0.063 0.0177 3.1546 0.460 0.697 0.634 0.818 0.813 0.620 0.494 0.658 0.758 0.972 0.1180 0.2071 0.2162 0.2435 0.2588 0.1993 0.1596 0.2040 0.2565 0.3347 23.268 37.839 33.263 40.157 42.388 33.514 26.502 33.883 37.543 50.757 0.692 0.2198 35.911 0.155 0.0591 7.8317 Group : VIII - 1000 mg/kg/day ANIMAL (Gms) OVARIES %FBW %BRAIN Sex :FEMALES (Gms) SPLEEN %FBW %BRAIN 641234 641256 641282 641352 641366 641377 641385 641387 641399 0.142 0.0471 7.9241 0.497 0.1650 27.734 0.085 0.0295 4.5382 0.521 0.1808 27.816 0.177 0.0427 8.9939 0.641 0.1545 32.571 0.130 0.0428 6.4103 0.489 0.1611 24.112 0.113 0.0364 5.6870 0.530 0.1709 26.673 0.136 0.0464 7.1958 0.516 0.1759 27.302 0.087 0.0271 4.7828 0.427 0.1332 23.474 0.158 0.0525 8.2983 0.525 0.1743 27.574 0.146 0.0427 7.6761 0.636 0.1859 33.438 Mean S.D. 0.130 0.0408 6.8341 0.031 0.0083 1.5737 0.531 0.1668 27.855 0.068 0.0159 3.3244 (Gms) THYMUS %FBW %BRAIN 0.234 0.229 0.481 0.233 0.242 0.223 0.283 0.222 0.245 0.0777 0.0795 0.1159 0.0768 0.0780 0.0760 0.0883 0.0737 0.0716 13.058 12.226 24.441 11.489 12.179 11.799 15.558 11.660 12.881 0.266 0.0819 13.921 0.083 0.0136 4.1324 (Gms) UTERUS %FBW %BRAIN 0.473 0.938 0.640 0.491 0.533 0.592 0.738 0.675 0.680 0.1570 0.3256 0.1543 0.1618 0.1719 0.2018 0.2303 0.2241 0.1987 26.395 50.080 32.520 24.211 26.824 31.323 40.572 35.452 35.752 0.640 0.2028 33.681 0.144 0.0541 8.0663 FBW - Final Body Weight 783 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 3-MONTH RECOVERY EVALUATION Group : II ANIMAL - 0 ing/kg/day PBW (Gms) (Gms) Sex : FEMALES LIVER %FBW 641241 641285 641288 641309 641394 300.8 326.9 317.5 318.5 342.3 10.718 8.303 10.830 9.555 9.523 3.5632 2.5399 3.4110 3.0000 2.7821 Mean S.D. 321.2 15.1 9.786 3.0592 1.034 0.4265 Group : IV - 50 nig/kg/day Sex : FEMALES ANIMAL FBW (Gms) (Gms) LIVER %FBW 641247 641319 641321 641340 641391 334.9 314.9 350.6 318.4 326.9 9.668 7.923 10.479 8.266 9.135 2.8868 2.5160 2.9889 2.5961 2.7944 Mean S.D. 329.1 14.3 9.094 2.7565 1.038 0.1975 FBW - Final Body Weight 784 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 3-MONTH RECOVERY EVALUATION Group : VI - 250 nig/kg/day Sex : FEMALES ANIMAL PBW LIVER | (Gms) (Gms) %FBW 641232 641262 641305 641372 641382 410.8 374.5 320.4 317.3 305.5 12.055 9.519 10.094 10.064 9.058 2.9345 2.5418 3.1504 3.1718 2.9650 Mean S.D. 345.7 45.1 10.158 2.9527 1.143 0.2532 Group : VIII - 1000 ing/kg/day Sex :FEMALES ANIMAL FBW (Gins) (Gais) LIVER %FBW 641259 641264 641278 641301 641395 409.8 381.3 325.9 392.3 349.6 11.057 11.335 9.404 10.618 12.302 2.6981 2.9727 2.8855 2.7066 3.5189 Mean S.D. 371.8 33.7 10.943 2.9564 1.059 0.3357 FBW Final Body Weight 785 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 APPENDIX L INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS 786 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS KEY TO APPENDIX LESION GRADING: Histopathological changes are described according to their morphologic character, distribution and severity. The distribution (extent of tissue involvement) is indicated, where appropriate, by modifiers such as focal, multifocal, diffuse, unilateral, bilateral, etc. A severity score, if appropriate, is also assigned as follows: MINIMAL: MILD: MODERATE: SEVERE: The amount of change present barely exceeds that which is considered to be within normal limits. In general, the lesion is easily identified but of limited severity. The lesion probably does not produce any functional impairment. The lesion is prominent but there is significant potential for increased severity. Limited tissue or organ dysfunction is possible. The degree of change is either as complete as considered possible or great enough in intensity or extent to expect significant tissue or organ dysfunction. COMMENT: Grades minimal through severe represent progressive involvement/severity along a continuum with minimal lesions being the least severe and severe lesions being the most severe. While the grades refer to the morphological characteristics of lesions, they also indicate their relative biological significance. Gross observations listing multiple masses for a tissue are distinguished with letters (i.e., a, b, c, d, etc.). 787 SamBSaiA Does not cwta'n TSSA '"-f H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641066 Terminal Sacrifice Killed on Day : 182 Exposure Group - FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, mild. minimal. No Microscopic Abnormality Observed : NOSE 788 . Does not confab "e^. -? H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______ DuPont-4739 INDIVIDUAL AWIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641069 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MAMDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES. URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, HEART : CARDIOMYOPATHY, minimal. PARATHYROID GLANDS : NOT PRESENT. EYE(S) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. minimal. minimal. 641069 Continued on the next page .... 789 Simpeuy SanlfeeA 0@es no8 errtain TSCA < H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641069 Continued from previous page Histopathology No Microscopic Abnormality Observed : KIDNEYS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS. MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 641070 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 641070 Continued on the next page 790 SanHbeA Does not contain T8CA CB? H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 nig/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641070 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. PANCREAS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. PROSTATE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 791 'Qmpwy Sanitized, not eontain TSCA CB! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641083 Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES. URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : No Microscopic Abnormality Observed : LIVER. THYROID GLAND, NOSE 641084 Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : 641084 Wo Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, Continued on the next page .... 792 WBpany Santeed. not ontain TSCA < H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641084 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 641085 Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 641085 Continued on the next page .... 793 Company Sanitized. Does not contain TSCA CB8 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641085 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHROWIC, THYROID GLAND : ALTERATION, COLLOID, mild. minimal. No Microscopic Abnormality Observed : NOSE 641094 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : 641094 No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, Continued on the next page .... 794 , not eonSafs TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641094 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAMD, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE. SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYS : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. PARATHYROID GLANDS : NOT PRESENT. minimal. BRAIN, No Microscopic Abnormality Observed : LIVER, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 795 iTSCACBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641098 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM. COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, FATTY CHANGE, THYROID GLAND : SUBACUTE/CHRONIC, minimal. MEDIAN CLEFT, mild. ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 796 Smted. Does mi contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_______ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641101 Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE 797 OH8pany Does not eonfq'n I-S^A CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 __ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641104 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE ^^^^.o------*^08' 798 3@e nrt? g--s<s~ .*< a f^QJ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations _ _ _DuPont-4739 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641105 Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIM, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopafchology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE 799 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____ ___ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref 641115 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVER : INFLAMMATION, FATTY CHANGE, THYROID GLAND : SUBACUTE/CHRONIC, minimal. PERIPORTAL, minimal. ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 800 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref 641123 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE 801 Company Sanitized, Does not eontain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641147 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 641147 Continued on the next page .... 802 Company Sanitized. Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : I - 0 ing/kg/day Sex: Males Animal Ref 641147 Microscopic & Macroscopic Findings Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS. MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 641149 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS. TRACHEA, ESOPHAGUS, PHARYNX/LARYNX. EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 641149 Continued on the next page .... 803 Does not eortain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : I - 0 ing/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641149 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HEART : CARDIOMYOPATHY, minimal. PANCREAS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. PARATHYROID GLANDS : NOT PRESENT. No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 804 Company Sanffized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641154 Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON. RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE 805 Company Sanitized. Does not eontai'R TSCA CBJ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641155 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. PARATHYROID GLANDS : NOT PRESENT. minimal. minimal. 641155 Continued on the next page 806 Company Sanitized Does not contain TSCA CBg H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641155 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, MOSE 641159 Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN. AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 641159 Continued on the next page .... 807 1 Does not esinlam TSCA ' H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______ _ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641159 Continued from previous page Histopathology : LIVER : INFLAMMATION, FATTY CHANGE, THYROID GLAND : SUBACUTE/CHRONIC, minimal. MEDIAN CLEFT, minimal. ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 641165 Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MAMDIBULAR LYMPH NODE. THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 641165 Continued on the next page .... 808 Company Sanitized. Does not c^fafn TSCA COI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref 641165 Microscopic & Macroscopic Findings Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 641172 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON. RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : 641172 LIVER : INFLAMMATION, SUBACUTE/CHRONIC, NECROSIS, FOCAL, minimal. Continued on the next page .... minimal. 809 Company Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641172 Continued from previous page Histopathology : LIVER : HYPERPLASIA, LUNGS : BILE DUCT, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. ESOPHAGUS : FIBROSIS, minimal. EYE(S) WITH OPTIC NERVE : FOLD/ROSETTE, RETINAL, minimal. No Microscopic Abnormality Observed : KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, PHARYNX/LARYNX, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 810 -CesBpanySanitized. Does not <^..r>t-!)8 if?<"^ f^y H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641206 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN. AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS. TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : 641206 LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART : CARDIOMYOPATHY, minimal. PANCREAS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. Continued on the next page .... 811 Sasipesy SanKteed, Doe not cmWn CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641206 Continued from previous page Histopathology No Microscopic Abnormality Observed : SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 641214 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 641214 Continued on the next page 812 not eontain TSCA CSJ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641214 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, HEART : CARDIOMYOPATHY, minimal. PANCREAS : ATROPHY, minimal. INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 813 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641215 Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 814 Ooffi^aaySaniteed. H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641220 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : MOSE 815 Company Sanitized. Does not contain TSCA CB( H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641222 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. GLANDS, No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID 641222 Continued on the next page 816 i Does not contain' H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641222 Continued from previous page Histopathology : No Microscopic Abnormality Observed : TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIM, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES. FEMUR/KMEE JOINT, STERNUM, BONE MARROW, NOSE 817 Company Sanitized. Does not contain H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III Animal Ref 50 mg/kg/day Sex: Males Microscopic & Macroscopic Findings 641055 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN. PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. 818 Company SanKizeA Does not contain TSCA CB! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : Animal Ref III - 50 mg/kg/day Sex: Males Microscopic & Macroscopic Findings 641056 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS. TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. 819 Company SanESEzed. Doss not eontam TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - Animal Ref 50 mg/kg/day Sex: Males Microscopic & Macroscopic Findings 641059 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, PATTY CHANGE, THYROID GLAND : SUBACUTE/CHRONIC, minimal. MEDIAN CLEFT, minimal. ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : NOSE 820 Company SaniSfeed. Does not contain TSCA CB8 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations__________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - Animal Ref 50 mg/kg/day Sex: Males Microscopic & Macroscopic Findings 641073 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. 821 Company SanESIzed. Does wt en^aw f^CA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III Animal Ref 641081 50 mg/kg/day Sex: Males Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Hisfcopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. HYPERPLASIA, BILE DUCT, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. 822 ompan]f Sanitized. Does not cw?a'"n TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : Animal Ref III - 50 mg/kg/day Sex: Males Microscopic & Macroscopic Findings 641113 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : LIVER : DISCOLORATION, TAN, MANY, < 2MM DIA. No Macroscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, moderate. HYPERPLASIA, BILE DUCT, minimal. PATTY CHANGE, PERIPORTAL, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. 641113 Continued on the next page .... 823 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - Animal Ref 50 nig/kg/day Sex: Males Microscopic & Macroscopic Findings 641113 Continued from previous page Histopathology : No Microscopic Abnormality Observed : NOSE 641144 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM. COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS. MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Hisfcopathology : 641144 LIVER : INFLAMMATION, FATTY CHANGE, THYROID GLAND : SUBACUTE/CHRONIC, minimal. PERIPORTAL, minimal. ALTERATION, COLLOID, minimal. Continued on the next page .... 824 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : Animal Ref III - 50 mg/kg/day Sex: Males Microscopic & Macroscopic Findings 641144 Continued from previous page Histopathology : NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. 641146 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, THYROID GLAND : SUBACUTE/CHRONIC, minimal. ALTERATION, COLLOID, minimal. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild. 825 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : Animal Ref III - 50 mg/kg/day Sex: Males Microscopic & Macroscopic Findings 641160 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS. CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Hisfcopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE CSSSeue^yanKbecl 826 not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : Animal Ref III - 50 mg/kg/day Sex: Males Microscopic & Macroscopic Findings 641178 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN. PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT. STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE 827 SanBtecfc Does not contain TSCA CB! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : HI - Animal Ref 50 mg/kg/day Sex: Males Microscopic & Macroscopic Findings 641194 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE. SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Hisfcopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 828 SwapanySanSlted. Does not contain TSCA CBJ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : Animal Ref III - 50 mg/kg/day Sex: Males Microscopic & Macroscopic Findings 641198 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAMD, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, PERIPORTAL, minimal. NECROSIS, FOCAL, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : NOSE 829 Does not contain T8CA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations __ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : Animal Ref III - 50 mg/kg/day Sex: Males Microscopic & Macroscopic Findings 641218 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : NOSE INFLAMMATION, FATTY CHANGE, : SUBACUTE/CHRONIC, minimal. MEDIAN CLEFT, minimal. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. No Microscopic Abnormality Observed : THYROID GLAND Company 830 rot contain TSCA CB8 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III Animal Ref 641224 50 mg/kg/day Sex: Males Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology Mo Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND. PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, MOSE Histopathology : LIVER : INFLAMMATION, FATTY CHANGE, NOSE : SUBACUTE/CHRONIC, minimal. PERIPORTAL, minimal. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. No Microscopic Abnormality Observed : THYROID GLAND Company 831 Does not contain TSCA CB( H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 50 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641225 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER. TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE 832 Company Sanftlzed. Does not contain TSCA CB"? H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations__________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641061 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology ; No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. 833 CompanySanitized. Does not contain TSCA C3( H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641076 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS. MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES. EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 834 Company Sanitized. Does not contain Tcsra CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 250 nig/kg/day Sex: Males Animal Ref 641089 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild. 835 OffipanySanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 250 mg/kg/day Sex: Males Animal Ref 641102 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, HEPATOCELLULAR, mild. INFLAMMATION. SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild. 836 ^QWpanySanBbed. Does not confab f<ffi ^ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 250 mg/kg/day Sex: Males Animal Ref 641134 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM. JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. 837 Svauwiy SanMzed. Does not contain TSCA cgt H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641137 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS. HEART, SKELETAL MUSCLE. SPLEEN. AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, HEPATOCELLULAR, mild. INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. 838 oinpuiiy Sanitized. Does not e*ww.i T-ecA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641141 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : NOSE 839 OonnpanySanHIzed. Does not contain TSCA CB( H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 250 nig/kg/day Sex: Males Animal Ref 641148 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. No Microscopic Abnormality Observed : NOSE 840 CompanySanitoed. Does not conta?n TSCA CS( H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641162 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON. RECTUM. MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. THYROID GLAND : HYPERTROPHY, FOLLICULAR, minimal. ALTERATION, COLLOID, mild. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION/NECROSIS. OLFACTORY, EPITHELIUM, mild. 841 Company Sanitized. Does not contain TSCA CB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641187 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS. SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, moderate. minimal. No Microscopic Abnormality Observed : NOSE 842 Company Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 250 ing/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641190 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES. URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION/NECROSIS, OLFACTORY. EPITHELIUM, mild. 843 Company SanBlzed. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ____ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641197 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY. HEPATOCELLULAR, mild- THTK6TD_GLAMD ALTERATlSH. 58iWlB, minimal, HYPERTROPHY, FOLLICUIAR, m-lnimal. NQ3E - DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild. 844 Company Sanitized. Does not conla?n TSCA CBft H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641200 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. FATTY CHANGE, MEDIAN CLEFT, mild. FATTY CHANGE, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild. 845 Company Sanltfcc&d. Does not contain T5CA OBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 250 mg/kg/day Sex: Males Animal Ref 641202 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild. 846 Company Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641057 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON. RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE 847 Company Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ret Microscopic & Macroscopic Findings 641064 Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM. MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS. TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY. HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, mild. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. 848 Company Sanitized. Does not confs'n ^SCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641067 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : 641067 LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, mild. Continued on the next page .... 849 Company Sanftlzed. Does nnt ^^ T<s^ ^g, H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641067 Continued from previous page Histopathology : NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild. No Microscopic Abnormality Observed : SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS. MANDIBULAR LYMPH NODE, THYMUS. ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 641077 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 641077 Continued on the next page .... 850 CompanySanitized. Does not contain TSCA CBl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641077 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR, mild. ALTERATION, COLLOID, mild. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN. SPINAL CORD, STOMACH. DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, 641077 Continued on the next page .... 851 Company Sanitized. Does not contain TSCA C8( H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641077 Continued from previous page Histopathology : No Microscopic Abnormality Observed : PHARYNX/LARYNX. EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 641086 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER. KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : 641086 LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. Continued on the next page .... 852 Company Sanitized. Does not contain TSCA CB( H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641086 Continued from previous page Histopathology : PANCREAS : ATROPHY, minimal. PITUITARY GLAND : CYST, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, mild. PARATHYROID GLANDS : NOT PRESENT. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 853 Company Sanitized. Does not contain TSCA CBt H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641092 Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. No Microscopic Abnormality Observed : NOSE 854 oompanysaniteed- D^ ot con^n TSCA cm H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 ing/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641095 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE. SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : 641095 LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR. mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR, mild. ALTERATION, COLLOID, moderate. Continued on the next page .... 855 col*'PWySanitized. Does not contain TSCA CBf H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641095 Continued from previous page Histopathology : NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, moderate. No Microscopic Abnormality Observed : SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 641097 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER. KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 641097 Continued on the next page .... 856 ^Pany Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641097 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. PANCREAS : ATROPHY, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, mild. PARATHYROID GLANDS : NOT PRESENT. NOSE : DEGENERATION/NECROSIS. OLFACTORY, EPITHELIUM, mild. 641097 Continued on the next page .... 857 CompanySanitized. Does not contain . SCA cdl H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 nig/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641097 Continued from previous page Histopathology : No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 641130 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN. PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 641130 Continued on the next page .... 858 Company Sanitized. Does not contain TSCA CBt H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641130 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : NOSE 641132 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LONGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM. PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE 641132 Continued on the next page .... 859 CompanySanSteed. Does not eontain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ___ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641143 Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopafchology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. 861 Does not eontain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : VII Animal Ref 1000 ing/kg/day Sex: Males Microscopic & Macroscopic Findings 641153 Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR, minimal. ALTERATION, COLLOID, moderate. No Microscopic Abnormality Observed : NOSE 862 Company Sanitized. Does not confam TSCA CB8 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641157 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS. LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, . ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAMD, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : 641157 LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. KIDNEYS : MEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR, minimal. ALTERATION, COLLOID, moderate. PROSTATE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. Continued on the next page .... 863 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ref 641157 Microscopic & Macroscopic Findings Continued from previous page Histopathology : SPINAL NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, mild. BRAIN, CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH MODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 641166 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 641166 Continued on the next page 864 ta?" 'y^1'" " -ifrt H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 ^s^ 'i"?'511?!! INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641166 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, mild. ESOPHAGUS : FIBROSIS, minimal. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild. GLANDS, No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID TRACHEA, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 865 SosStoA Does f@8etmgss's "yA ^af H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ____ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 ing/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641167 Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. NOSE : DEGENERATION/NECROSIS, OLFACTORY. EPITHELIUM, minimal. 866 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641169 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH MODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS. SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, mild. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. No Microscopic Abnormality Observed : NOSE 867 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641185 Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE. SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : HYPERTROPHY, POLLICULAR, minimal. ALTERATION, COLLOID, moderate. No Microscopic Abnormality Observed : NOSE 868 D@ noS contain TSCA r-iqi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII Animal Ref 1000 mg/kg/day Sex: Males Microscopic & Macroscopic Findings 641189 Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIM, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE. PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, mild. No Microscopic Abnormality Observed : NOSE 869 Does not contain TCCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 ing/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641196 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS. LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, mild. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. No Microscopic Abnormality Observed : NOSE 870 'in TSCA CBr H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641201 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM. PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS. PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : 641201 LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. FATTY CHANGE, MEDIAN CLEFT, minimal. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : HYPERTROPHY, FOLLICULAR, mild. ALTERATION, COLLOID, severe. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, Continued on the next page .... moderate. 871 & Does rot eontatn T@e^ ^q, H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641201 Continued from previous page Histopathology : NOSE : HYPERPLASIA/HYPERTROPHY, minimal. TRANSITIONAL CELL, EPITHELIUM, No Microscopic Abnormality Observed : KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES. URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 641203 Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : 641203 No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, Continued on the next page .... Swsapsas 872 Does noi eontate TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - Animal Ref 1000 mg/kg/day Sex: Males Microscopic & Macroscopic Findings 641203 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal. No Microscopic Abnormality Observed : NOSE 641205 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : 641205 No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, Continued on the next page .... 873 Does not soMatn TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - Animal Ref 1000 mg/kg/day Sex: Males Microscopic & Macroscopic Findings 641205 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopafchology : LIVER : HYPERTROPHY, HEPATOCELLULAR, minimal. FATTY CHANGE, CENTRILOBULAR, mild. FATTY CHANGE, PERIPORTAL, mild. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. 641213 Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : 641213 No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, Continued on the next page .... 874 Does ro8 certain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations__________ __DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641213 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal - THYROID GLAND : ALTERATION, COLLOID, severe. No Microscopic Abnormality Observed : NOSE 641216 Terminal Sacrifice Killed on Day : 122 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : 641216 No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS. ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, Continued on the next page .... 875 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : VII - Animal Ref 1000 mg/kg/day Sex: Males Microscopic & Macroscopic Findings 641216 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE. SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Hisfcopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, mild. No Microscopic Abnormality Observed : NOSE 641223 Terminal Sacrifice Killed on Day : 91 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : TESTES : LARGE, RIGHT. 641223 Continued on the next page .... 876 Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641223 Continued from previous page Gross Pathology : FEMUR/KNEE No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, EPIDIDYMIDES, JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCELLULAR, mild. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, mild. PARATHYROID GLANDS : NOT PRESENT. TESTES : DILATATION, SEMINIFEROUS TUBULES, UNILATERAL, NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild. mild. 641223 Continued on the next page .... 877 i?n T8CA ^q| H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : VII - 1000 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 641223 Continued from previous page Histopathology : ESOPHAGUS, FEMUR/KNEE No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, EPIDIDYMIDES, JOINT, STERNUM, BONE MARROW 878 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 641240 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA. BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA. ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, HEART : CARDIOMYOPATHY, minimal. minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, 641240 Continued on the next page .... 879 Does not contetn TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 641240 Continued from previous page Histopathology : No Microscopic Abnormality Observed : PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN. MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, MOSE 641241 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLAMDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : 641241 THYROID GLAND : ALTERATION, COLLOID, Continued on the next page .... minimal. SaMpaay 880 Doe not contain TSCA f H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 ing/kg/day Sex: Females Microscopic & Macroscopic Findings 641241 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LIVER, NOSE 641245 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : 641245 LIVER : INFLAMMATION, SUBACUTE/CHRONIC, HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. Continued on the next page .... minimal. 881 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 641245 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings Continued from previous page Histopafchology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH MODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 641249 Accidentally Killed Duration of dosing-days: 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : LUNGS : DISCOLORATION, DARK, DIFFUSE. No Macroscopic Abnormality Observed : LIVER. KIDNEYS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, 641249 Continued on the next page .... ^OBBpasy 882 Does nog contain 7SGA ^ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 _____ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 641249 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SPLEEN : SUBACUTE/CHRONIC, PIGMENT INCREASED, mild. STOMACH : CYST, KERATIN, minimal. PARATHYROID GLANDS : NOT PRESENT. minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIM, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 883 i?nT8CA CBi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations___________ DuPont-4739 IMDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 641253 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, . THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Hisfcopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 884 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 nig/kg/day Sex: Females Microscopic & Macroscopic Findings 641257 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA. BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, . THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYMX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, PANCREAS : ATROPHY, minimal. PITUITARY GLAND : MOT PRESENT. PARATHYROID GLANDS : NOT PRESENT. minimal. 641257 Continued on the next page 885 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 641257 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, THYROID GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 641266 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM. PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 641266 Continued on the next page .... 886 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 641266 Continued from previous page Histopathology : LIVER : INFLAMMATION, FATTY CHANGE, THYROID GLAND : SUBACUTE/CHRONIC, minimal. MEDIAN CLEFT, mild. ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 641281 . Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER. KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAMD, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 641281 Continued on the next page .... 887 , Boes no? contafrn rsca rw H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 641281 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 641283 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS. CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : 641283 LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. Continued on the next page .... 888 s'RTgCACat H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : II Animal Ref 0 ing/kg/day Sex: Females Microscopic & Macroscopic Findings 641283 Continued from previous page Hi s topathology Wo Microscopic Abnormality Observed : KIDNEYS, LUNGS. HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM. BONE MARROW, NOSE 641285 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : 641285 No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Continued on the next page .... 889 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 641285 Continued from previous page Histopathology : LIVER : INFLAMMATION, NOSE : INFLAMMATION, SUBACUTE/CHROMIC, SUBACUTE/CHRONIC, minimal. minimal. No Microscopic Abnormality Observed : THYROID GLAND 641288 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYMX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 641288 Continued on the next page .... 890 Does not eontaft, TSCACB? H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 641288 Continued from previous page Histopathology : LIVER : INFLAMMATION, NOSE : INFLAMMATION, SUBACUTE/CHRONIC, SUBACUTE/CHRONIC, minimal. minimal. No Microscopic Abnormality Observed : THYROID GLAND 641290 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE 641290 Continued on the next page .... 891 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 641290 Continued from previous page Histopathology : LIVER : INFLAMMATION, KIDNEYS : SUBACUTE/CHRONIC, minimal. NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. PANCREAS : ATROPHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. EYE(S) WITH OPTIC NERVE : FOLD/ROSETTE, RETINAL, minimal. SPINAL No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, CORD, STOMACH, DUODENUM. JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE. THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 892 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 641293 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS. SCIATIC NERVE, PITUITARY GLAND, . THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX. EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 893 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 641294 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, . THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopafchology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 894 Company Sanitized, Does not eontain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 ing/kg/day Sex: Females Microscopic & Macroscopic Findings 641309 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, PAT Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : LIVER, NOSE 895 Sanitized, not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 641325 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLAMDS, MAMDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN. MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopafchology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. .minimal. No Microscopic Abnormality Observed : NOSE 896 Company Sanitized. Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 641331 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, . THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Hiptopafchology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 897 Company Sanitized. Does not eonSam TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 641335 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA. BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, KIDNEYS : SUBACUTE/CHRONIC, minimal. HYDRONEPHROSIS, UNILATERAL, minimal. PANCREAS : ATROPHY, minima1. EYE(S) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. 641335 Continued on the next page 898 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641335 Continued from previous page Histopathology SPINAL No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), . OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 641344 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : 641344 No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD. STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYMX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Continued on the next page .... 899 Company SanKIzed. Does not contain TSCA CB! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 641344 Continued from previous page Histopathology : PANCREAS : ATROPHY, minimal. THYROID GLAND : ALTERATION, COLLOID, ESOPHAGUS : PIBROSIS, minimal. minimal. GLANDS, No Microscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS. HEART, SKELETAL MUSCLE, SPLEEN, . AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID TRACHEA, PHARYNX/LARYNX. EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 641359 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : LIVER : HERNIA. 641359 Continued on the next page .... 900 CQMpany SanStbed. Does no! ronfain T8CA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 641359 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE 901 SanHteed. Does not contain H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ____ ___ DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 641364 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD. STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM. NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE 902 oot eortew T: !, H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 641383 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, FATTY CHANGE, THYROID GLAND : SUBACUTE/CHRONIC, minimal. MEDIAN CLEFT, minimal. ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 903 i TSCA ^-f. H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 641384 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM. PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON. RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE 904 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 641394 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM. PANCREAS, CECUM, COLON, RECTUM, MESEMTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAMD : ALTERATION, COLLOID, minimal. NOSE : ATROPHY, UNILATERAL, NASAL GLANDS, severe. 905 .Company Sanitized. Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - Animal Ref 0 mg/kg/day Sex: Females Microscopic & Macroscopic Findings 641400 Terminal Sacrifice Killed on Day : 123 Exposure Group : RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, FATTY CHANGE, THYROID GLAND : SUBACUTE/CHRONIC, minimal. MEDIAN CLEFT, minimal. ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 906 Company Sanitized. Does not contain TSCA CB1 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 50 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641247 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN. MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, FATTY CHANGE, THYROID GLAND : SUBACUTE/CHRONIC, minimal. MEDIAN CLEFT, minimal. ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE 907 Company Sanitized. Does not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 50 ing/kg/day Sex: Females Animal Ref 641260 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH. DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 908 Company SanIISzed. not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : IV - 50 mg/kg/day Sex: Females Animal Ref 641298 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIM, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KMEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE 909 .Company SanEIEzed. not contain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________ ____DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 50 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641311 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : Wo Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART. SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Hisfcopathology : LIVER : INFLAMMATION, FATTY CHANGE, SUBACUTE/CHRONIC, minimal. MEDIAN CLEFT, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 910 .Company Sanitized. Does not contain TSCA CB! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 50 nig/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641312 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHROMIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAMD (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHROMIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE Company 911 Does not eontain TSCA CBI H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 50 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641313 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS. MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION/NECROSIS. OLFACTORY, EPITHELIUM, minimal. 912 i Does no? eonta'n TS^A H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 50 mg/kg/day Sex: Females Animal Ref 641319 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Hisfcopafchology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. minimal. 913 Company SanKfead. Does not contain' H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 50 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641321 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : LIVER, NOSE 914 Company Sanitized. Does not contain TSCA cri H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 50 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641336 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH. DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Hisfcopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 915 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations __ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 50 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641340 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM. MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE 916 tin TSCA ^^t H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____ DuPont-4739 __ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 50 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641355 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MAMDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS. SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE 917 Company SanSSteed. Does not contain TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 50 mg/kg/day Sex: Females Animal Ref 641361 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE. SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESEMTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 918 Conipan^ SanISIzed. Does not congaEn TSCA CBS H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : IV - 50 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641369 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS. ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, THYROID GLAND : SUBACUTE/CHRONIC, minimal. ALTERATION, COLLOID, minimal. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. Gempmy 919 Does not contain TSCA CB? H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations _________ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 50 ing/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641391 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM. ILEUM. PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE 920 Company SaniSizsd. Does not contain TSCA CBi H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 50 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641396 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 921 Company Sanitized. Doss not ewta'n TSCA fflt H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : VI - 250 mg/kg/day Sex: Females Animal Ref 641232 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER. FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE 922 Company Sanitized. De not contain TSCA CBB H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 250 mg/kg/day Sex: Females Animal Ref 641244 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN. SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE Company 923 D@s not contain! H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641251 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH MODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. 924 Cempwy Santeecj. Does not contain TSCA CT? H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : VI - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641262 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH MODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : LIVER, NOSE 925 Company SanRfced. Does not contain T8CA CB8 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : VI - 250 mg/kg/day Sex: Females Animal Ref 641269 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, NOSE : SUBACUTE/CHRONIC, minimal. INFLAMMATION, SUBACUTE/CHRONIC, mild. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, mild. HYPERPLASIA/HYPERTROPHY, TRANSITIONAL CELL, EPITHELIUM, minimal. No Microscopic Abnormality Observed : THYROID GLAND 926 Santeed. Does rot contain TSCA ^ H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations ___ _______DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641292 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH MODE, SALIVARY GLANDS, MAMDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM. NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE 927 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 250 ing/kg/day Sex: Females Animal Ref 641302 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MAMDIBULAR LYMPH MODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, FATTY CHANGE, THYROID GLAND : SUBACUTE/CHRONIC, minimal. MEDIAN CLEFT, minimal. ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. No Microscopic Abnormality Observed : NOSE 928 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641305 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES. UTERUS, URINARY BLADDER, PEMUR/KMEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 929 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641362 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART. SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE). OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. 930 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________ DuPont-4739 ___ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641363 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 931 H-24616: Subchronic Toxicity ___ 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____ DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 250 mg/kg/day Sex: Females Animal Ref 641372 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM. MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE). OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROID GLAND : ALTERATION. COLLOID, minimal. No Microscopic Abnormality Observed : LIVER, NOSE 932 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641375 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MAMDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. No Microscopic Abnormality Observed : NOSE 933 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641379 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : THYROID GLAND, NOSE 934 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : VI - 250 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641382 Terminal Sacrifice Killed on Day : 182 Exposure Group : FLUORINE ANALYSIS Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUMUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Higstopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, FATTY CHANGE, FOCAL, mild. THYROID GLAND : ALTERATION, COLLOID, minimal. minimal. No Microscopic Abnormality Observed : NOSE 935 H-24616: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-4739 INDIVIDUAL ANIMAL GROSS AMD MICROSCOPIC OBSERVATIONS Dose Group : VI - 250 ing/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 641398 Terminal Sacrifice Killed on Day : 92 Exposure Group : SUBCHRONIC Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, MAMMARY GLAND (FEMALE), OVARIES, UTERUS, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, NECROSIS, FOCAL, minimal. NOSE : minimal. DEGENERATION/NECROSIS, OLFACTORY, EPITHELIUM, minimal. No Microscopic Abnormality Observed : THYROID GLAND 936