Document JvyK8X77X4EpJErO35L54142r

HEALTH EFFECTS, HANDLING, AND FIRST AID Health and Environmental Sciences T.I.M.E. SYSTEM DR-0002-5310 C uVTEST REVISIONS: HEXACHLOROBENZENE 05/17/92 This info rma t .1 on ap p 1 i es to th e s ta ted ma te r :i. a I an d ma y n ot apply to dilutions or formulations of the material* CAS NUMBER: 000118-74-1 OTHER IDENTIFIERS: K-002688 synonyms: benzene, hexachloro- PERCHLOROBENZENE HCB PAGE 12/11/9 REPT Z CHEMICAL AND PHYSICAL PROPERTIES These data compiled from various sources and not verified* Additional Information is available through your site's Reactive Chemical Program. appearance: white needles MOLECULAR WEIGHT4, 284,80 BOILING POINT: 322 C MELTING POINT: 229 C (SUBLIMES) VAPOR PRESSURE: <1 mm Hg 6 25C 1 mm Hq r? 114.4C LASH POINT: 242 C STAB ILITY/REACTIVIT Y: VERY STABLE -- UNREACTIVE ODOR DESCRIPTION.4 musty, oily, solvent-like POTENTIAL HEALTH EFFECTS (Rev i. sed : 05/17/92: This section include? possible adverse effects which could occur If this iti a t e r i a 1 x s n o t h a n d 1 e d i n t he r e c o m iti e n d e d m a n n e r * C. ' c. v - Essentially nonirritatinq to eyes* SKIN: - Essentia 11y nonirritating to sKin* - A single prolonged exposure is not likely to result in the material being absorbed through skin in harmful amounts. The LD50 for skin absorption in rabbits is >2000 mg/kg* Repeated skin contact presents a hazard due to accumulation of HCB in the body, INORSTIon: C j. n g 3. e d o s e a r a 3. t o x c x t y i s low. The or : I LD50 for rats js 3500 mg/kg* - Although single-dose oral toxicity i.s veseril: hazard due to accumulation low, ingestion of small of HCB in the body* amounts TRADEMARK COMPANY RESTRICTED r<,J r1>1 iw tJierL" D0 A 060954 CONFIDENTIAL r) tj HEALTH EFFECTS, HANDLING, AND FIRST AID Health and Environmental Sciences T.I.M.E. SYSTEM DR-0002-5310 HEX A CHLOROBENZENE PAGE 12/11/9 REFT Z ACUTE INHALATION EFFECTS: - Vapors are unlikely due to physical properties. - Exposure to dusts may contribute to the accumulation of MCB in the body. SUBCHRONIC effects: - Excessive exposure may cause neurologic signs and symptoms. - Observations in animals include ovarian effects. - Repeated excessive exposures may cause altered blood/bile pigment metabolism (porphyria) and liver, kidney, skin, nervous, skeletal, muscular and immune system effects. CHRONIC EFFECTS / CARCINOGENICITY: - Has been shown to cause cancer in laboratory animals. - For hazard communication purposes under OSHA Standard 29 CFR Part 1910.1200, this chemical is listed as a potential carcinogen by NTP and I ARC. TERATOGEN!C EFFECTS: - Has caused birth defects in laboratory animals only at doses toxic to the mothe r. - Has been toxic to the fetus in laboratory animals at doses nontoxic to the mother. - Toxicity to the neonate but not birth defects have occurred in offspring of humans known to have ingested toxic amounts of hexachlorobenzene. REPR0DUCTIVC EFFECTS: ~ In animal studies, has been shown to interfere with reproduction . - HCB .is bioconcentrated in body fat and is transferred to the Fei us placen ta and t o t h e n eona t e via 1a c t a tio n. via the mutagenicity: - Results of in vitro ('test tube") mutagenicity tests have been negative. -- Results of mutagen ic i ty tests in animals have been negative. EXPOSURE GUIDELINES Hexachlorobenzene: Dow Biological Limit Guide is 150 ppb in the blood. There is no guideline for airborne concentrations. * TRAD EM API" OF THE DOW CHE MI. CAL COMPANY RESTRICTED DOW u: ONLY DO A 060955 CONFIDENTIAL HEALTH EFFECTS, HANDLING, AND FIRST AID Health and Environmental Sciences T.I.M.E. SYSTEM PAGE 3 12/11/92 DR-0002-5310 / HEXACHLOROBENZENE REFT Z C:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: HANDLING PRECAUTIONS AND PROTECTIVE EQUIPMENT (REVISED:05/06/37) These recommended precautions are intended for use during normal operating conditions! emergency conditions could require additional precautions. (For an explanation of the low, moderate and high potential exposure categories or specific recommendations for your specific operation contact your industrial hygienst.) EYE LOW - Use safety glasses. -MODERATE - Use safety glasses. HIGH - Use safety glasses. SKIN LOW - No precautions other than clean body-covering clothing should be needed. MODERATE - Use protective clothing impervious to this material. Selection of specific items such as gloves, boots, apron, or full-body suit will depend on operation. HIGH - Use protective clothing impervious to this material-. Selection of specific items such as gloves, boots, apron, or full-body suit will depend on operation. INHALATION LOU - No respiratory protection should be needed. MODERATE - Use an approved air-purifying respirator. HIGH - Use an approved respirator. Selection of air-purifying or positive-pressure supplied-air will depend on the specific operation and the potential airborne concentration of the i material. INGESTION - Avoid ingestion of even very small amounts! do not consume or store food or tobacco in the work area? wash hands and face before smoking or eating. WARNING PROPERTIES! - Odor is inadequate warning of excessive exposure. VENTILATION - Good general ventilation should be sufficient for most conditions. PROTECTIVE EQUIPMENT INFORMATION - The following should be effective protective clothing materials! neoprene, nitrile butadiene rubber. - There are no respirator test data available for this chemical or mixture. Data for related chemicals indicate that the following should be effective types of air-purifying respirators! organic vapor with dust prefilter. ( * TRADEMARK OF THE DOW CHEMICAL COMPANY IGTRICTED - DOW USE ONLY Do A 06095/; confideNtia* HEALTH EFFECTS, HANDLING, AND FIRST AID Health and Environmental Sciences T.I.M.E. SYSTEM c DR-0002-5310 HEXACHLOROBENZENE PAGE 4 12/11/92 REPT Z EMERGENCY TREATMENT AND MEDICAL NOTES Revised .*05/06/92) EYE - Flash eyes with plenty of water. SKIN - Wash off in flowing water or shower. INGESTION - Induce vomiting if large amounts are ingested. Consult medical personnel. INHALATION - Remove to fresh air if effects occur. Consult a physician. NOTES TO PHYSICIAN: - Individuals with chronic or long time exposure to hexachlorobenzene should receive biological monitoring of blood levels. - No specific antidote. - Supportive care. Treatment based on judgment of the physician in response to reactions of the patient. END OF REPORT J FOR ADDITIONAL INFORMATION CONTACT.* Chemical Hazard Evaluation and Communication Health and Environmental Sciences 1803 Building, Midland, MI 48674 Phone (517) 636-9097 * TRADEMARK OF THE DOW CHEMICAL COMPANY RESTRICTED - DOW USE ONLY DO A 060957 CONFIDENTIAL