Document JvNGgQXKeMkJG5b3LXMa7RMZ6

4 ** * ft#*####*##*-*#****##*#*## P0092717 * ft * THIS IS AN OFF-LINE BIBLIOGRAPHIC CITATION LIST GENERATED BY ft * ft * MEDLARS II ft * ft * N.L.M.'S NATIONAL INTERACTIVE RETRIEVAL SERVICE ft * ft * ft ftttftftftftftftftftftffftftftftftftftftftftffftftftftftftftftftftftftftffftftftftftftftftftftftftftftftftftftffftftftffffftttftftftftftftftftft .J # I>1,1-TRICHLOROETHANE NUMBER OF CITATIONS PRINTED = 209 this Search was performed on the toxune MAY 20, 1986 file. SORT = (ELEMENTS/DIRECTIONS GIVEN BY USER) WAS SPECIFIED US PLEASE SEND THIS LISTING TO PLfcASE KW 'fff,tS tit * V 0 4t ' 0 DIANA DANKO / PPG INDUSTRIES,INC. P.O. BOX II BARBERTON* OHIO 4429? . ^; : ' 'v, ,-LlN - "!" <v.'; .) .. - -i? . SL B30145 OOO1 8 9 TITLE AUTHOR AUTHOR AUTHOR SOURCE 10 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 11 TITLE AUTHOR SOURCE 12 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 13 TITLE AUTHOR AUTHOR AUTHOR SOURCE # 19 TITLE AUTHOR # AUTHOR SOURCE II 1,1, 1 -TRICH LOROETHANE PAG^ 2 Method for detection of volatile organic halogenated compounds in human and animal tissues Alles G Bauer U Selenka F Zentralbl. Bakteriol., Mikrobiol. Hyg.> Abt. It Orig. B VOL 179, ISS 3, 1981,238-98 Chemical quantification of unscheduled DNA synthesis in cultured hepatocytes as an assay for the rapid screening of potential chemical carcinogens Althaus FR Lawrence SD Sattler GL Longfellow DG Pi tot HC Cancer Res.i VOL 92, ISS 8, 1982,3010-15 The central plant of the St. Louis County Water Company Anon Aqua t London); ISS 9, 1981,20-9 Chlorinolysis conversion of chloroorganie byproducts to carbon tetrachloride under pressure Antonov VN Zalikin AA Toropov MS Sorokotyaga IS Zimin VM Il'ln BA Khim. Prom-st. (Moscow), ISS 5, 1981,287-9 Hollow cellulose fibers for dialysis Aoyagi J Takahara K Seita Y Fr. Demande PATENT NO. 2506792 12/03/82 (Teeumo Corp.) Summary report on the performance of bacterial repair, phage induction, degranulation, and nuclear enlargement Ashby J Kilbey B Prog. Mutat. Res. i VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Collab. Program, 1981,33-98 assays SL 030147 00013929 15 TITLE AUTHOR AUTHOR SOURCE 16 TITLE AUTHOR AUTHOR SOURCE 17 TITLE AUTHOR AUTHOR AUTHOR SOURCE IS TITLE AUTHOR SOURCE 19 TITLE AUTHOR AUTHOR SOURCE 20 TITLE AUTHOR SOURCE 1,1,1-TRICH L0R0ETHANE PAGE 3 Health hazard evaluation Report No. HHE-80-240-855, New York Uhiversityt New York> New York Baker 0 Fannick N Report; ISS HHE-80-240-855; Order No. PB82-215294, , 1981,21 pp. Study of 42 coded compounds with the Sa 1mone11a/mamraa1 ian microsome assay Baker RS U Bonin AM Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Collab. Program, 1981,249-60 Concurrent measurement of solvent vapor concentrations and effects on operant behavior using a dynamic exposure system Balster RL Moser VC Woolverton WL J. Pharmacol. Methods; VOL 8, ISS 4, 1982,299-309 Human exposure to environmental chemicals studies on volatile organic halogenated compounds in water, air, food, and human tissues. III. Results of studies Bauer U Zentralbl. Bakteriol., Mtkrobfol. Hyg., Abt. 1, Orig. Bf VOL 174, ISS 3, 1981,200-37 TOXICITY OF VOLATILE ORGANIC COMPOUNDS PRESENT INDOORS BEALL JR ULSAMER AG COMMITTEE ON PUBLIC HEALTH OF THE NEW YORK ACADEMY OF MEDICINE SYMPOSIUM ON HEALTH ASPECTS OF INDOOR AIR POLLUTION, NEW YORK, N.Y., USA, MAY 28-29, 1981. BULL N Y ACAD MED; 57 (10). 1981 (RECD. 1982). 978-996. Major toxicological features of chlorinated solvents Beutel KK Safe Use Solvents, Proc. Int. Symp.; 1982,105-16 SL 030148 00013930 1,1,1-TRICHLOROETHANE PAGE 9 21 TITLE AUTHOR AUTHOR SOURCE 2 TITLE AUTHOR AUTHOR AUTHOR SOURCE 23 TITLE AUTHOR AUTHOR SOURCE 29 TITLE AUTHOR AUTHOR SOURCE 25 TITLE AUTHOR AUTHOR SOURCE 26 TITLE AUTHOR AUTHOR SOURCE 27 TITLE AUTHOR AUTHOR SOURCE Effects of selected organic drinking water contaminants on male reproduction Borzelleca JF Ca^chman RA Report! ISS EPA-600/1-82-009! Order No. PB82-259897,, 1982,199 pp. Trace organic behavior In loll eoluwm during rapid infiltration of secondary wastewater. BOUWER EJ MCCARTY PL LAMCE JC MATER RES; 15 C1J. 1981. 151-160. The toxicity of twelve fumigants to three species of mites infesting grain Bowley CR Bell CH J. Stored Prod. Res.; VOL 17, ISS 2, 1981,83-7 A study of some aromatic and halocarbon vapors in the ambient atmosphere of New Jersey Bozzelli JH Kebbekus BB J. Environ. Sci. Health, Part A! VOL A17, ISS 5, 1982,693-11 Results of toxic action of water pollutants on Daphnia magna Straus tested by an improved standardized procedure Bringraann G Kuehn R 2. Masser Abwasser Forseh.; VOL 15, ISS 1, 1982,1-6 Summary report on the performance of in vitro mammalian assays Brookes P Preston RJ J Prog. Hutat. Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog. ' Rep. Int. Collab. Program, 1981,77-85 Mutagenic activity of 92 coded compounds the Salmonella/microsome assay with preincubation Brooks TM Dean BJ Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int, Collab. Program, 1981,261-70 in SL 030149 000^^1 28 TITLE AUTHOR SOURCE 29 TITLE AUTHOR AUTHOR SOURCE 30 TITLE AUTHOR SOURCE 31 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 32 TITLE AUTHOR AUTHOR AUTHOR AUTHOR rt AUTHOR AUTHOR AUTHOR SOURCE o 33 TITLE AUTHOR SOURCE TITLE AUTHOR AUTHOR AUTHOR SOURCE I 1,1,1-TRICHLOROETHANE o Effect of alterations In drug metabolism on epinephrine-induced cardiac arrhythmias in rabbits exposed to methylchloroform Carlson SP Toxicol. Lett.; VOL 9, ISS 4, 1981,307-13 Acute inhalation toxicity of some halogenated and halogenated hydrocarbons Clark'DS Tins ton OJ Hum. Toxicol.; VOL 1, ISS 3, 1982,239-97 Organic solvent chromatography of radioactive sodium pertechnetate Cloutet W J. Nucl. Med. Technol.; VOL 10, ISS 1, 1982,20-2 Priority pollutants in industrial effluents Colby BN Beimer RG Rushneck DR Telliard WA Int. Environ. Saf.! ISS Feb., 1982,8-13 Determination of organic contaminants by the Grob closed-loop-stripping technique. COLEMAN WE MELTON RG SLATER RW KOPFLER FC V0T0 SJ ALLEN WK AURAND TA AM WATER WORKS ASSOC J; 73 (2J. 1981. 119-125. Laboratory evaluation of commercially available passive organic personal monitors Coutant RW Report; ISS EPA-600/9-82-031; Order No. PB82-239261,, 1982,39 pp. Zorotest Dambly C Toman Z Radman M Prog. Mutat, Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Collab. Program, 1981,219-23 O o SL 030150 0001^2 35 TITLE AUTHOR AUTHOR SOURCE 36 TITLE AUTHOR AUTHOR SOURCE 37 TITLE AUTHOR SOURCE 30 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 39 TITLE AUTHOR AUTHOR SOURCE' 40 TITLE AUTHOR AUTHOR SOURCE 11111-TRICH LOROETHANE PAG! 6 Cell trans-formation test with baby hamster kidney cells Daniel HR Dehnel JM Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Collab. Program) 1901,626-37 Health hazard evaluation report HETA 81-040-969, Gyro-Tech Incorporated, Greendale, Wisconsin Daniel WJ Orris P Report; ISS HETA-61-048-969; Order Ho. PS83-161265,> 1981,12 pp. Emissions from open top vapor degreasing systems Darvin CH U. S. Environ. Prot. Agency, Off. Res. Dev., tRep.l EPA; ISS EPA-600/2-81-020, Conf. Adv. Pollut. Control Met. Finish. Ind., 3rd, PB81-191900,, 1981,98-101 Chemicals as central nervous system depressants. Benefits of an animal model De Ceaurriz J Bonnet P Cert in C Muller J Guenier JP Cah. Notes Doc.; VOL 104,, 1981,351-5 Summary report on the performance of yeast assays De Serres FJ Hoffmann GR Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Careinog.: Rep. Int. Collab. Program, 1981,68-76 Two-dimensional model studies of methyl chloroform in the troposphere Derwent RG Eggleton AE J Q. J. R. Meteorol. Soc.[ VOL 107, ISS 451, 1981,231-42 030151 St 00013933 41 TITLE AUTHOR AUTHOR AUTHOR SOURCE 42 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR f''i SOURCE TITLE AUTHOR SOURCE TITLE o AUTHOR AUTHOR AUTHOR o AUTHOR SOURCE TITLE o AUTHOR AUTHOR SOURCE <3 TITLE AUTHOR AUTHOR # AUTHOR AUTHOR SOURCE m a 1,1,1-TRICHLOROETHANE PAGE 7 j o Volatile halo hydrocarbons in wastewaters and sludges Dietz F Traud J Koppe P Vom Wasser; VOL 58,, 1982,187-205 GC-HS analysis of volatile organics from atmospheres impacted by the AMOCO CADIZ oil spill Dowty BJ Brown JW Stone FN Lake J Laseter JL Amoco Cadiz! Consequences Pollut. Accid. Hydrocarbures, Actes Colloq. Int.J 1981,13-22 Corrosion-free plastic solvent-recovery plants Ouerst J Oberflaeche-Surf., VOL 23, ISS 5, 1982,179-80 Case history and use of a mobile GC/MS laboratory Dymerski P Palmer A Oahlgran J Insalaco S Hazard. Mater. Spills Conf. Proc.; 1982,15-21 Headspace gas chromatographic analysis of foods for volatile halocarbons Entz RC Hollifield HC J. Agric. Food Chem.; VOL 30, ISS 1, 1982,84-8 Selective electron-capture sensitization Fehsenfeld FC Go1dan PO Phillips MP Sievers RE J. Chromatogr. Libr.; VOL 20, ISS Electron Capture: Theory Pract. Chromatogr., 1981,69-90 m m m SL 030152 00^^34 47 TITLE AUTHOR AUTHOR AUTHOR SOURCE 48 TITLE AUTHOR AUTHOR AUTHOR SOURCE 49 TITLE AUTHOR SOURCE 50 TITLE AUTHOR AUTHOR AUTHOR SOURCE 51 TITLE AUTHOR AUTHOR AUTHOR SOURCE 52 TITLE AUTHOR SOURCE 1,1,1-TRICHLOROETHANE PAGE 8 Development of the degranulation test system Fey EG White HA Rabin BR Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Card nog.: Rep. Int. Collab. Program, 1931*236-44 Increased acetone exhalation induced by metabolites of halogenated Cl and C2 compounds Filser JG Jung P Bolt HM Arch. Toxicol.; VOL 49, ISS 2, 1982,107-16 Groundwater pollution by manufacturing and use of chlorinated solvents from the industrial viewpoint Fricke H DVGW-Schriftenr., Wasser! VOL 29, ISS Halogenkohlenwasserst. Grundwaessern, 1981,119-32 Parameters of the fire hazard of some chemical substances Frolov YE Evlanov SF Vorozhtsova ES Khim. Prom-st., Sen.: Khlornaya Prom-st.J ISS 3, 1981,14-16 Determination of organic solvent vapor tn air. Experimental study on recovery efficiencies of charcoal tube method Fukabori S Tada 0 Sugai T Rodo Kagaku; VOL 57, ISS 1, 1981,11-23 Mutagenic activity of 42 coded compounds the "microtiter" fluctuation test Gatehouse Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Collab. Program, 1981,376-86 in SL 030153 00013935 53 TITLE AUTHOR SOURCE 54 TITLE AUTHOR SOURCE 55 TITLE AUTHOR AUTHOR SOURCE 56 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 57 TITLE AUTHOR SOURCE 58 TITLE AUTHOR AUTHOR SOURCE 59 TITLE AUTHOR AUTHOR SOURCE 1.1,1-TRICH LOROETHANE PAGE 9 EFFECT OF POLY CHLORO PINENE ON THE ERYTHROCYTES IN THE ROACH RUTILUS-RUTILUS GDOVSKII PA J EVOL BIOCHEM PHYSIOL (ENGL TRANSL ZH EVOL BIOKHIM FIZIOL); 17 (1). 1981. 56-57. The effect of polychloropinene on the erythrocytes (n the roach Rutilus rutilus. GDOVSKII PA ZH EVOL BIOKHIM FIZIOL; 17 (1). 1981. 70-71. Removal of chlorinated solvents from water Gehring R Hess M Swiss PATENT NO. 626594 11/30/81 tSchweizerische Sodafabrik) Mutagenicity of cosmetics ingredients licensed by the European Communities Gocke E King MT Eckhardt K Wild 0 Mutat. Res.; VOL 90, ISS 2, 1981,91-109 A differential killing test using an Improved repair-deficient strain of Escherichia coli Green MH L Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Careinog.: Rep. Int. Collab. Program, 1981,183-94 Calculation of adsorption breakthrough curves In air cleaning and sampling devices Srubner O Burgess MA Environ. Sci. Technol.J VOL 15, ISS 11, 1981,1346-51 Frequency of fugitive emissions in synthetic organic chemical plants Harris GE Tichenor BA Proc. Annu. Meet. - Air Pollut. Control Assoc.! VOL 74th, ISS Vol. 3, 1981,Paper 81-41.5, 8 pp. SL 030154 00013936 60 TITLE AUTHOR AUTHOR SOURCE 61 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 62 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR Source 63 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 64 TITLE AUTHOR AUTHOR AUTHOR SOURCE 1,1.1-TRICHLOROETHANE PAGE 10 Response -factors for VOC analyzers used in fugitive emission monitoring Harris GE Tichenor BA Energy Environ. Chem.; VOL 1,, 1962,293-319 Groundwater pollution from industrial waste disposal. A case study Harris GR Garlock C LeSeur L Mesinger S Waxier R J. Environ. Health; VOL 44, ISS 6, 1982,287-95 Methods for detecting gaseous and volatile carcinogens using cell transformation assays Hatch GG Mamay PD Ayer ML Casto BC Nesnow S Environ. Sci. Res.; VOL 25, ISS Genotoxic Eff. Airborne Agents, 1982,75-90 IN-VITRO TRANSFORMATION OF HAMSTER EMBRYO CELLS EXPOSED TO GASEOUS OR VOLATILE CHLORINATED HYDRO CARBONS HATCH GG MAHAY PD CHRISTENSON CC CASTO BC LANGENBACH R NESNOW S 72ND ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, INC., WASHINGTON, D.C., USA, APRIL 27-30, 1981. PROC AM ASSOC CANCER RES AM SOC CLIN ONCOL; 22 (0). 1981. 119. ACUTE TOXICITY OF 54 INDUSTRIAL CHEMICALS TO SHEEPSHEAD MINNOWS CYPRINODON-VARIEGATUS HEITMULLER PT HOLLISTER TA PARRISH PR BULL ENVIRON CONTAM TOXICOL; 27 (5). 1981. 596-604. SL 030155 f' 00013937 1 >It1-TRICHLOROETHANE PAGE 11 i 65 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 66 TITLE c AUTHOR SOURCE Passive dosimeter air monitoring - field validations Hemingway RE Dixon SW Louie CA Wiernicki C Ber. Int. Kolloq. Verhuetung Arbeitsunfaellen Berufskr. Chem. Ind.} VOL 6th,, 1932,373-88 ANALYSIS OF FISH AND SEDIMENT FOR VOLATILE PRIORITY POLLUTANTS HIATT MH ANAL CHEM! 53 (9). 1981. 1541-1543. a Pi o o 67 TITLE Q AUTHOR SOURCE O 68 TITLE o AUTHOR AUTHOR SOURCE o 69 TITLE o AUTHOR AUTHOR AUTHOR AUTHOR o AUTHOR SOURCE Survey of chemical substances in the atmosphere Hi mi Y Kanagawa-ken Taiki Osen Chosa Kenkyu Hokoku; VOL 23,, 1981,163-6 Caudal nerve conduction velocity determination in the rat and the effects of 1,1,1-trichlorethane Hi rata M Ando K Osaka-furitsu Koshu Eisei Kenkyusho Kenkyu Hokoku, Rodo Eisei Hen; VOL 20,, 1982,39-44 Organic solvent levels following intravenous administration, in the bile, blood and liver of dogs Hobara T Kobayashi H Higashihara E Iwaraoto S Ssksi T Nippon Eiseigaku Zasshi ; VOL 37, ISS 3, 1982,601-7 0 0 0 70 TITLE AUTHOR 0 AUTHOR AUTHOR AUTHOR AUTHOR 0 AUTHOR AUTHOR AUTHOR SOURCE Effects of organic solvents on superoxide dismutase activities in erythrocytes and organs of dog Hobara T Kobayashi H Iwamoto S Higashihara E Hirota S Kawamoto T Shimaau H Sakai T Yamaguchi Igaku; VOL 30, ISS 4, 1981,439-43 0 SL 030156 0 00013935 71 TITLE AUTHOR AUTHOR AUTHOR SOURCE 72 TITLE AUTHOR AUTHOR SOURCE 73 TITLE AUTHOR AUTHOR SOURCE 74 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 75 TITLE AUTHOR SOURCE 76 TITLE AUTHOR SOURCE 1,1,1-TRICHLOROETHANE PAGE 12 Continuous monitoring of water using process chromatography - determination of halogenated hydrocarbons Hoerner G Kuehn W Leonhardt D Vom Wasser; VOL 59,, 1982,115-28 SOURCES AMD CONCEH1RATIONS OF ORGANIC COMPOUNDS IN INDOOR ENVIRONMENTS HOLLOWELL CD MIKSCH RR COMMITTEE ON PUBLIC HEALTH OF THE NEW YORK ACADEMY OF MEDICINE SYMPOSIUM ON HEALTH ASPECTS OF INDOOR AIR POLLUTION, NEW YORK, N.Y., USA, MAY 28-29, 1981. BULL N Y ACAD MED; 57 (10). 1981 (RECO. 1982). 962-977. Sources and concentrations of organic compounds in indoor environments Hollouell CD Miksch RR Bull. N. Y. Acad. Med.; VOL 57, ISS 10, 1981,962-77 Fluctuation test with S9 and hepatocyte activat ion Hubbard SA Green KH L Bridges BA Wain AJ Bridges JW Prog. Mutat. Res. i VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Collab. Program, 1981,361-70 Removal of priority pollutants with a combined powdered activated carbon-activated sludge process Hutton DG Chem. Water Reuse", VOL 2,, 1981,403-26 Treatability of toxic wastewater pollutants by solvent extraction Hwang ST AIChE Symp. Ser. ; VOL 77, ISS 209, 1981,304-15 SL 030157 m 00013939 77 TITLE AUTHOR AUTHOR AUTHOR SOURCE 76 TITLE AUTHOR O AUTHOR AUTHOR SOURCE o 79 TITLE o AUTHOR AUTHOR SOURCE o 60 TITLE o AUTHOR AUTHOR AUTHOR SOURCE Q 81 TITLE & AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 1,1.1-TRICHLOROETHANE PAGE 13 v_' o Mutagen testing of a series of paired compounds with the Ames Salmonella testing system Ichinotsubo 0 Mower H Mandel M Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Collab. Program, 1981,98-301 Testing of a series of paired compounds (carcinogen and noncarcinogenic structural analog) by DNA repaii--deficient E. coli strains Ichinotsubo 0 Mower H Mandel M Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Collab. Program, 1981,195-8 Chloroethaness their metabolism by hepatic cytochrome P-950 in vitro Ivanetich KM Van den Honert LH Carcinogenesis (London); VOL , ISS 8, 1981,697-702 Genetic activity of 92 coded compounds In the mitotic gene conversion assay using Saccharomyces cerevisiae strain 09 Jagannath DR Vultaggio DM Brusick DJ Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog.! Rep. Int. Collab. Program, 1981,956-67 Uptake via the blood and elimination of 10 organic solvents following epicutaneous exposure of anesthetized guinea pigs Jakobson I Wahlberg JE Holmberg B Johansson G Toxicol. Appl. Pharmacol.! VOL 63, ISS 2, 1982,181-7 o o I i i $ 030^8 si* 00013940 82 TITLE AUTHOR AUTHOR AUTHOR SOURCE 83 TITLE AUTHOR SOURCE 84 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 85 TITLE AUTHOR AUTHOR AUTHOR SOURCE 86 TITLE AUTHOR AUTHOR SOURCE 87 TITLE AUTHOR AUTHOR SOURCE 1 ,1,1-TRICHLOROETHANE PAGE 14 Organic contaminants in indoor air and their relation to outdoor contaminants Jarke FH Drawl eks A Gordon SM ASHRAE Trans.; VOL 87, ISS 1, 1981,153-66 The -damaging activity of 42 coded compounds in the rec-assay Kada T Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Collab. Program, 1981,175-82 Activity of 40 coded compounds in differential inhibition and mitotic crossing-over assays in yeast Kassinova GV Koval'tsova SV Marfin SV Zakharov IA Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Collab. Program, 1981,434-55 Mutagenic activity of polycyclic aromatic hydrocarbons and other environmental pollutants Katz M Heddle JA Salamone MF Chem. Anal, and Biol. Fate! Polynucl. Aromat. Hydrocarbons, Int. Symp., 5th; 1981,519-28 DECLINE IN THE ATMOSPHERIC ACCUMULATION RATES OF TRI CHL0R0FLU0R0 METHANE FLUORO CARBON 11 DI CHLORODIFLUORO METHANE FLUORO CARBON 12 AND METHYL CHLOROFORM KHALIL M AK RASMUSSEN RA J AIR P0LLUT CONTROL ASSOC; 31 <12.1. 1981. 1274-1275. Methylchloroform. Cycles of global emissions Khalil MA K Rasmussen RA Environ. Sci. Technol.; VOL 15, ISS 12, 1981,1506-8 SL 030159  ,, (x 0I 00013991 1,1>1-TRICHLOROETHANE PAGE 15 . il 1 l 'Kjr o o o o o ; /' u u o & Q :O rj> 88 TITLE AUTHOR AUTHOR SOURCE 89 TITLE AUTHOR SOURCE 90 TITLE AUTHOR SOURCE 91 TITLE AUTHOR SOURCE 92 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 93 TITLE AUTHOR SOURCE Omnipresent concentration of C1-C6 chlorocarbons in the unpolluted atmosphere Kirschmer P Ballschmiter K BPT-Ber.i ISS BPT-Ber. 2/81, Einfluesse Umweltchem. KlimaBiol. Folgeuirkungen,> 1981,85-92 Structural-chemical parameter as a criterion for classification of environmental contaminants Koch R Chemosphere! VOL 11, ISS 5, 1962,511-20 Health hazard evaluation report no. HETA-81-167-953, Allegheny Ludlum Steel Corporation, West Leechburg, Pennsylvanla Kominsky JR Report; ISS HETA-81-167-953; Order No. PB83-129056,, 1981,9 pp. Quantitative structure-activity relationships in fish (Poecilia reticulata) toxicity studies: 1. Relationship for 50 industrial pollutants. KONEMANN H toxicology; 19 m. 1981. 209-222. Fiftieth anniversary of Lake Baldeney - some special topics in water resources management Koppe P Kornatzki KH Nusch EA Dietz F Reinnarth G GWF, Gas- Hasserfach: Masser/Abwasser; VOL 123, ISS 1, 1982,17-29 Study on the precision of the activated charcoal solvent desorption procedure correlation of desorption efficiencies Koval M Collect. Czech. Chem. Commun.; VOL 96, ISS 6, 1981,1332-97 O; i l Q 0 O a 0 Q 0 0 m i 0 i1 1 m m su 0^0 # # 00013942 94 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 95 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 96 TITLE AUTHOR AUTHOR AUTHOR SOURCE 97 TITLE AUTHOR AUTHOR AUTHOR SOURCE 98 TITLE AUTHOR AUTHOR AUTHOR SOURCE 99 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 1,1,1-TRICH LOROETHANE PAGE 16 Development of a volatile organic analysis technique for the Orange-Los Angeles County reuse study Krasner SW Hwang CJ Cohen RS McGuire MJ Chem. Hater Reuse! VOL 2,, 1981,17-31 Notes and comments! leaching of organics from a PVC-polyethylene-plexiglass pilot plant Kreft P Trussell A Lang J Kavanaugh M Trussell R J. - Am. Water Works Assoc.! VOL 73, ISS 10, 1981,558-60 Skin pathology following epicutaneous exposure to seven organic solvents Kronevi T Wahlberg JE Holmberg B Int. J. Tissue React.! VOL 3, ISS 1, 1981,21-30 Accumulation and migration of polychloropinene in chernozems. KULIKOVA A KH NUGMANOV N KH SADREEVA LG POCHVOVEDENIE! 0 (12). 1981 tRECO. 126-128. 1982). Controlled environment portable gas chromatograph for in situ aircraft or balloon-borne applications. KUSTER WC GOLOAN PD FEHSENFELD FC J CHROMATOGRi 205 (2). 1981. 271-280. Analysis of organic priority and nonpriority pollutants in environmental samples by GC/MS/computer systems Lao RC Thomas RS Bastien P Halman RA Lockwood JA Pergaraon Ser, Environ. Sci .! VOL 7, ISS Anal. SL 030161 00013943 (w 100 TITLE c AUTHOR SOURCE Q 101 TITLE Q AUTHOR AUTHOR SOURCE 102 TITLE & AUTHOR AUTHOR SOURCE O 103 TITLE AUTHOR AUTHOR AUTHOR w SOURCE 0 104 TITLE AUTHOR AUTHOR AUTHOR # AUTHOR SOURCE 105 TITLE AUTHOR SOURCE 1,1,1-TRICHLOROETHANE a PAGE 17 Tech. Environ. Chem. 2, 1982,107-18 Technical assistance report no. 80-108-762 at Hubert Humphrey Building, Washington, DC Lee SA Report; ISS TA-60-108-762J Order No. PB82-162512,, 1981,7 pp. Health hazard evaluation report No. TA-80-111-826, Department of Commerce, Washington, DC Lee SA Mullan QS Report; ISS TA-80-111-826; OrderNo. PB82-188178,, 1981,15 pp. Distribution coefficients of chlorinated hydrocarbons in dilute air-water systems for groundwater contamination applications Leighton DT Jr Calo JM J. Chem. Eng. Data; VOL 26, ISS 4, 1981,382-5 Removal of refractory organics from water by aeration! 1. Methyl chloroform. LIONEL T WILSON DJ PEARSON DE SEP SCI TECHNOL! 16 (8). 1981 (RECD. 1982). 907-936. Tropospheric chemistry: a global perspective Logan JA Prather MJ Wofsy SC MeElroy MB JGR, J. Geophys. Res., [Sect.] C*, VOL 86, ISS C8, 1981,7210-54 Screening of coded carcinogenic/noncarcinogenic chemicals by a forward-mutation system with the yeast Schizosaccharomyces pombe Loprieno N Prog. Mutat. Res.f VOL 1, ISS Eval. Short-Term Tests Careinog.: Rep. Int. Collab. Program, 1981,424-33 a & u # a m % 030162 # 00013944 o 106 TITLE o AUTHOR SOURCE Q 107 TITLE AUTHOR AUTHOR AUTHOR SOURCE 108 TITLE AUTHOR SOURCE 109 TITLE AUTHOR AUTHOR AUTHOR SOURCE 110 TITLE AUTHOR AUTHOR SOURCE 0 111 TITLE O AUTHOR AUTHOR SOURCE J 112 TITLE 0 AUTHOR AUTHOR SOURCE 0 0 lil.1-TRICHLOROETHANE * PAGE Id Health hazard evaluation report no. TA-80-51-603, United States International Communication Agency. Washington. D.C Love JR Report; ISS TA-80-51-803; Order No. PB82-1S4599,. 1981,6 pp. Fate of priority pollutants in large municipal treatment plants Lue-Hing C Lordi DT Kelada NP AIChE Symp. Ser.i VOL 77, ISS 209, 1981,144-50 Salmonella/microsome tests on 42 coded chemicals MacDonald DJ Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Careinog.5 Rep. Int. Collab. Program, 1981,285-97 Ultratrace analysts of atmospheric halocarbons Mata de Y Kanai Y Tominaga T Nippon Kagaku Kaishi; ISS 1, 1981,133-44 Tropospheric concentrations of methylchloroform, CH3CC13, in January 1978 and estimates of the atmospheric residence times for hydrohalocarbons Makide Y Rowland FS Proc. Natl. Acad. Sci. U. S. A.J VOL 78, ISS 10, 1981,5933-7 Health hazard evaluation report no. HHE-79-158-819, Morrilton Plastics Corporation, Morrilton, Arkansas Markel HL Jr Slovin 0 Report; ISS HHE-79-158-819; Order No. PB82-189766,, 1981,18 pp. Testing of 42 coded compounds for their ability to induce unscheduled DNA repair synthesis in HeLa cells Martin CN McDerraid AC Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Collab. Program, 1981,533-7 m 030l63 00013945 Q Q 113 TITLE AUTHOR V AUTHOR AUTHOR AUTHOR AUTHOR V SOURCE 114 TITLE <9 AUTHOR AUTHOR & AUTHOR AUTHOR SOURCE <9 115 TITLE AUTHOR AUTHOR SOURCE 116 TITLE AUTHOR AUTHOR SOURCE m 117 TITLE AUTHOR AUTHOR SOURCE 1,1,1-TRICHLOROETHANE PAGE 19 u l Reverse mutation test on 42 coded compounds with the E. coli WP2 system Matsushima T Takamoto Y Shirai A Sautamura M Sugimura T Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Collab. Program, 1981,367-95 Evaluation of passive monitors for assessing vapor degreaser emissions Mazur JF Rinehart DS Esposito GG Podolak GE Am. Ind. Hyg. Assoc. J., VOL 42, ISS 10, 1981,752-6 Health hazard evaluation report no. HETA-81-207-945, Metropolitan Sewer District, Cincinnati> Ohio McGlothlin JD Cone JE Report; ISS HETA-81-207-945; Order No. PB83-127399,, 1981,39 pp. Mutagenic activity of 42 encoded compounds the haploid yeast reversion assay, strain XV185-14C Mehta RD Von Borstel RC Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Collab. Program, 1981,414-23 In IMPACT OF MUNICIPAL TREATMENT PLANTS ON TOXIC POLLUTANTS IN WASTE WATER MILLER GR BURCH N8 THE 1981 NATIONAL ASSOCIATION OF ENVIRONMENTAL PROFESSIONALS CONFERENCE ON TOXIC AND HAZARDOUS SUBSTANCES: A UNIFYING CONCEPT FOR THE ENVIRONMENTAL PROFESSION IN THE 1980'S. ENVIRON PROF; 3 (1-2). 1981 (RECD. 1962). 79-84. & m y qjt IT * # m m SL 030164 m m ' 00013996 1,1,1-TRICHLOROETHANE PAGE 20 Q 118 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR 0 SOURCE 119 TITLE Q AUTHOR a AUTHOR AUTHOR AUTHOR SOURCE a 120 TITLE Q AUTHOR AUTHOR $ AUTHOR AUTHOR SOURCE 9 121 TITLE AUTHOR SOURCE a 122 TITLE AUTHOR Si*%'' AUTHOR AUTHOR AUTHOR SOURCE 0 j a Evaluation of methodology for the survey analysis of solid wastes Miller HC James RH Dickson HR Neptune MD Carter MH ASTM Spec. Tech. Publ.i VOL 760, ISS Hazard. Solid Haste Test., 1981,290-66 Metabolic activation of p-nitrotoluene and ' trichloroethylene by rat-liver S9 or mouse-liver S9 fractions in Salmonella typhimurium strains. MIYATA R NQHMI T YOSHIKAWA K ISHIDATE M JR BULL NATL INST HYG SCI (TOKYO); 0 (99). 1981 (RECO. 1982). 60-65. Metabolic activation of p-nitrotoluene and trichloroethylene by rat liver S9 or mouse liver S9 fractions in Salmonella typhimurium strains Miyata R Nohmi T Yoshikawa K Ishidate MJ Eisei Shikensho Hokoku; ISS 99, 1981,60-5 Some aspects of the comparative toxicology of chlorinated solvents Moses AM Safe Use Solvents, Proc. Int. Symp.j 1982,117-28 Analysis of halocarbons in air Murayama H Maruyama T Mukai H Ocaki K Niigata-ken Kogai Kenkyusho Kenkyu Hokoku; VOL 6,, 1982,96-100 m ! i SL 030165 m L -i i Jf ** i Q 00013947 O' i 123 TITLE AUTHOR AUTHOR SOURCE & e & # 0 124 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 125 TITLE AUTHOR SOURCE 126 TITLE 0 AUTHOR SOURCE 0 127 TITLE AUTHOR m AUTHOR AUTHOR AUTHOR SOURCE m -- ; .128 TITLE & AUTHOR AUTHOR AUTHOR AUTHOR m SOURCE m m 1,1,1-TRICHL0R0ETHANE PAGE El U Mutagenic activity of 42 coded compounds the salmonella/microsome assay Nagao M Takahashi Y Prog. Mutat. Res.! VOL 1, ISS Eval. Short-Term Tests Careinog.: Rep. Int. Collab. Program> 1981,302-13 In Glove permeation by organic solvents. NELSON GO LUM BY CARLSON GJ WONG CM JOHNSON JS AM IND HYG ASSOC JI 42 (3). 1981. 217-225. Cleaning of metals with chlorinated hydrocarbons - an environmentally friendly alternative Nemynar H Oberflaechentech., Vortr. SURTEC-Kongr.} 1981,167-73 Contribution to the development of systematic cleanup procedures for soil- and groundwater contaminations. Use of soil-air analysis for location of contaminants. Avoidance of secondary pollution during soil exchange Neumayr V Bewertung Chem. Stoffe Wasserkreislauf; 1981,37-52 Tropospheric degradation mechanisms for halogenated hydrocarbons Nielsen OJ Bjernov E Pagsberg P Sillesen A Risoe Natl. Lab., [Rep.] Rtsoe-M (Den.); ISS Risoe-M-2337,, 1982,17 pp. . Tropospheric degradation mechanisms of chlorofluorocarbons Nielsen 0J Bj arnov E Pagsberg P Sillesen A Report; ISS RISO-M-2337,, 1982,17 pp. m 0 0 m 0 /V. # m m m SL 030166 m m 00013950 o o 141 TITLE AUTHOR AUTHOR SOURCE 142 TITLE AUTHOR AUTHOR SOURCE 143 TITLE AUTHOR AUTHOR AUTHOR SOURCE O 144 TITLE o AUTHOR AUTHOR SOURCE 145 TITLE AUTHOR AUTHOR SOURCE 146 TITLE ' AUTHOR AUTHOR SOURCE 147 TITLE AUTHOR AUTHOR SOURCE O J 1,1,1-TRICH LOROETHANE PAGE 24 Inhibition of microsomal drug oxidations by aliphatic ha1ohydrocarbons! correlation with vapor pressure Poplawski-Tabarelll S Uehleke H Xenobiotica; VOL 12, ISS 1, 1962,55-61 Summary report on the performance of in vivo assays Purchase IF H Ray V Prog. Mutat. Res.i VOL 1, ISS Eval. Short-Term Tests Carcinog.i Rep. Int. Collab. Program, 1981,66-95 Performance of the Porton Down charcoal cloth diffusive sampler Purnell CJ Wright HD Brown RH Analyst (London); VOL 106, ISS 1262, 1981,590-8 Detection and identification of volatile organic compounds in blood by headspace gas chromatography as an aid to the diagnosis of solvent abuse Ramsey JD Flanagan RJ J. Chromatogr.; VOL 240, ISS 2, 1982,423-44 INCREASE IN THE CONCENTRATION OF ATMOSPHERIC METHANE RASMUSSEN RA KHALIL (1 AK ATMOS ENVIRON! 15 (5). 1961. 883-686. Interlaboratory comparison of fluorocarbon-11,12-methylchloroform and nitrous oxide measurements. RASMUSSEN RA KHALIL M AK ATMOS ENVIRON! ATENBP 15 (9). 1981. 1559-1568. Global atmospheric distribution and trend of methylchloroform (CH3CC13) Rasmussen RA Khalil MA K Geophys. Res. Lett.; VOL 8, ISS 9, 1981,1005-7 m o 0301&7 m 00013951 m it 14B TITLE AUTHOR AUTHOR m AUTHOR SOURCE 149 TITLE AUTHOR m AUTHOR SOURCE m 150 TITLE AUTHOR SOURCE m 151 TITLE AUTHOR m AUTHOR SOURCE 152 TITLE m AUTHOR AUTHOR SOURCE m 153 TITLE m AUTHOR AUTHOR AUTHOR SOURCE m -- m 154 TITLE AUTHOR AUTHOR SOURCE m 1.1,1-TRICH LOR0ETHANE PAGE 25 n m Atmospheric trace gases in Antarctica Rasmussen RA Khalil MA K Dalluge RW Science (Washington, D. C., 1883-3, VOL 211, ISS 4479, 1981,285-7 Differences in the concentrations of atmospheric trace gases in and above the tropical boundary layer Rasmussen RA Khalil MA K Pure Appl. Geophys.J VOL 119, ISS 5, 1981,990-7 Effects of chlorinated solvents metal-working plant Ravazzolo F AESi VOL 3, ISS 2, 1981,84-9 in a Characterization of organic materials at Water Factory 21 Reinhard M McCarty PL Chem. Water Reuse! VOL 2,, 1981,33-53 Mutagenic activity of 42 coded compounds the Salmonella/microsome assay Richold M Jonas E Prog. Mutat. Res.! VOL 1, ISS Eval. Short-Term Tests Careinog. ' Rep. Int. Collab. Program, 1981,314-22 in DNA polymerase deficient assay Rosenkranz HS Hyman J Leifer Z Prog. Mutat. Res.! VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Collab. Program, 1981,210-18 Mutagenicity of carcinogens and noncarcinogens in the Salmonella/microsome test Rowland I Severn B Prog. Mutat. Res.*, VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Collab. Program, 1981,323-32 m m m 0 * m m m m m . o^6 00013952 0 155 TITLE AUTHOR AUTHOR SOURCE 156 TITLE AUTHOR SOURCE 157 TITLE AUTHOR AUTHOR SOURCE 158 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 159 TITLE AUTHOR SOURCE 160 TITLE AUTHOR AUTHOR AUTHOR SOURCE o . 1,1,1-TRICHL0R0ETHANE PAGE 26 Electrostatic potential around halogenated anesthetics. Acidic hydrogen; chlorine vs. fluorine Ruelle P Sandorfy C Int. J. Quantum Chem.; VOL 22, ISS 9, 1982,691-707 Health hazard evaluation report no. HETA-61-021-850, Pacific Power and Light Company, Rawlins, Wyoming Ruhe RL Report; ISS HETA-81-021-850I Order No. PB83-103838,, 1981,9pp. Fully automated analysis of volatile organic compounds in water with headspace capillary gas chromatography Sadowski C Purcell J Chromatogr. Newsl., VOL 9, ISS 2, 1981,52-5 Organic solvent levels in expiratory air of exposed workers. Sagawa M Uehimura N Koyama S Hatano H Ito K Kasiwamura S Tetsudo Yakugaku Kenkyu Nempo; VOL 29,, 1981,99-103 Toxicity of 91 carcinogens and noncarcinogenic analogs Salamone ttF Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog.i Rep. Int. Collab. Program, 1981,682-5 Mutagenic activity of 91 compounds in the In vivo micronucleus assay Salamone MF Heddle JA Katz M Prog. Mutat. Res.! VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Coll&b. Program, 1981,686-97 ^ si. 0301^9 30169 & 00013953 161 TITLE AUTHOR AUTHOR AUTHOR SOURCE 162 TITLE AUTHOR SOURCE 163 TITLE AUTHOR SOURCE 16A TITLE AUTHOR SOURCE 165 TITLE AUTHOR SOURCE 166 TITLE AUTHOR SOURCE 167 TITLE AUTHOR AUTHOR SOURCE 1,1,1-TRICHLOROETHANE PAGE 27 Microsomal dechlorination of chloroethanes' structure-reactivity relationships Salmon AG Jones RB Mackrodt WC Xenobiotica; VOL 11, ISS 11, 1981,723-39 Hashing fluid for recovery of organic materials, specifically solvents from wastewater Samhaber F Ger. Offen. PATENT NO. 3213520 12/16/62 (Andritz-Ruthner Industrieanlagen A.-G.) Chromosomal aberrations In the lymphocytes of workers during the use of polychloropinene in agriculture Samosh LV Tsitol. Genet.; VOL 15, ISS 1, 1961,62-7 CHROMOSOME ABERRATIONS IN LYMPHOCYTES OF PERSONS HORKING HITH POLY CHLORO PINENE UNDER AGRICULTURAL CONDITIONS SAMOSH LV CYTOL GENET CENGL TRANSL TSITOL GENET); 15 (1). 1961. 55-60. Pharmacokinetics, pharmacodynamics and aspects of neurotoxic effects of A inhaled aliphatic chlorohydrocarbon solvents as relevant in man. SAVOLAINEN H EUR J DRUG METAB PHARMACOKINET; 6 (2). 1981. 85-90. Volatile halogenated hydrocarbons in drinking water Schoessner H Forum Staedte-Hyg.! VOL 33, ISS 5, 1982,281-5 Bench scale assessment of concentration technologies for hazardous aqueous waste treatment Schuekrow AJ Pajak AP U. S. Environ. Prot. Agency, Off. Res. Dev., tRep.l EPA; ISS EPA-600/9-81-0026, Land Disposal! Hazardous Haste, Proc. Annu. Res., 7th, PB81-173882,, 1981,391-51 SL 030170 00013959 r"\ 16S TITLE AUTHOR AUTHOR SOURCE 169 TITLE AUTHOR AUTHOR SOURCE 170 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 171 TITLE AUTHOR SOURCE 172 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 173 TITLE AUTHOR SOURCE 1,1,1-TRICH LOROETHANE PAGE 26 Induction of mitotic gene conversion by 91 coded compounds using the yeast culture JD1 Sharp DC Parry JM Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Collab. Program, 1981,991-501 Use of repair-deficient strains of yeast to assay the activity of 90 coded compounds Sharp DC Parry JM Prog. Mutat. Res.! VOL 1, ISS Eval. Short-Tervn Tests Carcinog.: Rep. Int. Collab. Program, 1981,502-16 Measurements of some potentially hazardous organic chemicals in urban environments. SINGH HB SALAS LJ SMITH AJ SHIGEISHI H ATMOS ENVIRON; 15 t9). 1981. 601-612. Fabrics for surgical splints or casts end methods for stiffening such fabrics Sirisena SO A1 Eur. Pat. Appl. PATENT NO. 29727 06/03/81 (Byford, D., and Co. Ltd.) Summary determination of organic halogen compounds from water samples. Mineralization of thermally stable compounds in an oxygen stream Stache1 B Lahl U Kozicki R Podbielski A Schroeer W Thiemann W Chemosphere; VOL 11, ISS 8, 1982,803-9 Activity of 92 coded compounds in the BHK-21 cell transformation test Styles JA Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Collab. Program, 1981,638-96 $ *|. A 3 Q SL 030171 O -J 00013955 174 TITLE AUTHOR AUTHOR SOURCE 175 TITLE AUTHOR SOURCE 176 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 177 TITLE AUTHOR AUTHOR SOURCE 178 TITLE AUTHOR AUTHOR SOURCE 179 TITLE AUTHOR SOURCE m 180 TITLE AUTHOR AUTHOR AUTHOR SOURCE 1,1,1-TRICH LOROETHANE PAGE 29 Alt' monitoring of a hazardous waste site Sul1ivan DA Strauss JB Manage. Uncontrolled Hazard. Haste Sites, Natl. Conf.; 1981,136-42 The reductive treatment of industrial wastewaters. II. Process applications Sweeny KH AIChE Symp. Ser.i VOL 77, ISS 209, 1981,72-8 Biodegradability studies with organic priority pollutant compounds Tabak HH Guave SA Mashni Cl Barth EF J. - Hater Pollut. Control Fed., VOL 53, 10, 1981,1503-18 ISS Effect of chlorinated ethanes and ethylenes on electron transport in rat liver mitochondria Takano T Miyazaki Y J. Toxicol. Sci.; VOL 7, ISS 2, 1982,143-9 Health hazard evaluation report no. HETA-81-015-898, Bradford Hestern Corporation, Arvada, Colorado Thoburn TH Gunter BJ Report! ISS HETA-81-015-898; Order No. PB82-258112,, 1981,12 pp. Mutagenic activity of 42 coded compounds the lambda induction assay Thomson JA Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Careinog.! Rep. Int. Collab. Program, 1981,224-35 in Changes in rat liver microsomal cytochrome P-450 and enzymatic activities after the inhalation of n-hexane, xylene, methyl ethyl ketone and methylchloroform for four weeks Toftgaard R Nilsen OG Gustafsson JA Scand. J. Work, Environ. Health; VOL 7, ISS 1, 1981,31-7 e,V # # 0 * m m 00013956 181 TITLE AUTHOR AUTHOR AUTHOR SOURCE 182 TITLE AUTHOR SOURCE 183 TITLE AUTHOR SOURCE 184 TITLE AUTHOR AUTHOR SOURCE 185 TITLE AUTHOR SOURCE 186 TITLE AUTHOR SOURCE 1,1,1-TRICHLOROETHANE PAGE 30 Changes in rat liver microsomal cytochrome P-450 and enzymatic activities after the inhalation of n-hexane, xylenei wethylethyl ketone and methylchloroform for 4 weeks. TOFTGARO R GUSTAFSSON J-A NILSEN OG SCAND J WORK ENVIRON HEALTH, 7 tl). 1981. 31-37. Evaluation of some chemicals by the sperm morphology assay Topham JC Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Collab. Program, 1981,718-20 Activity of 42 coded compounds in the Salmonella reverse mutation test Trueman RW Prog. Hutat. Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog.! Rep. Int. Collab. Program, 1981,343-50 Activity of coded compounds in the micronucleus test Tsuchimoto T Matter BE Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Collab. Program, 1981,705-11 Activity of 42 coded compounds in a differential killing test using Escherichia coli Strains WP2, WP67 luvrA polA), and CM871 (uvrA lexA recA) Tweats DJ Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Collab. Program, 1981,199-209 . Organohalogen compounds in the air of some Berlin public swimming pools Ullrich D WaBoLu-Ber.! ISS 1, 1982,50-2 Q SL 030173 3 00013957 * 187 TITLE AUTHOR AUTHOR SOURCE m 188 TITLE m AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 189 TITLE AUTHOR .SOURCE 190 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 191 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 1,1,1-TRICHLOROETHANE PAGE 31 Mutagenicity of 42 coded compounds in a bacterial assay using Escherichia coll and Salmonella typhimurium 11 S Crofton-Sleigh C Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Card nog.: Rep. Int. Collab. Program, 1981>351-60 Quantitative analysis of chlorofluorocarbons. Absolute calibration of the electron-capture detector Vidal-Madjar C Parey F Excoffler JL Bekassy S J. Chromatogr.; VOL 203,, 1981,247-61 Pi lot-scale Investigations with granular activated carbon Vincent RJ Effluent Hater Treat. J.; VOL 21, ISS 8, 1981,351-4, 356-7 Serum en2yme activities and histological changes after percutaneous application of methylchloroform Viola A Sigon M Pittoni G Sarto F Pennelli M Med. Lav.! VOL 72, ISS 5, 1981,410-15 Mutagenic activity of 17 coded compounds the sex-linked recessive lethal test in Drosophila melanogaster Vogel E Blijleven HG H Kortselius MJ H Zi jlstra JA Prog. Mutat. Res.; VOL 1, ISS Eval. Short-Term Tests Carcinog.: Rep. Int. Collab. Program, 1981,660-5 in 00013956 192 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 193 TITLE AUTHOR AUTHUR AUTHOR AUTHOR SOURCE 199 TITLE AUTHOR AUTHOR SOURCE 195 TITLE AUTHOR AUTHOR SOURCE 196 TITLE AUTHOR AUTHOR AUTHOR AUTHOR 1,1,1-TRICHLOROETHANE PAGE 32 Volatile halogenated hydrocarbons in air, water, and foods in the Federal Republic of Germany. Analysis and evaluation of human ingestion Von Duesseln J Lahl U Baetjer K Cetir.'. aya M Stachel B Thiemann U Gabel B Kosicki R Podbielski A Dtsch. Lebensm.-Rundsch.! VOL 76, ISS 10, 1982,352-6 Volatile chlorocarbons in municipal wastewater and their distribution in surface waters Von Duesseln J Lahl U Stachel B Thiemann W Z. Wasser Abuasser forsch.; VOL 15, ISS 6, 1982,272-7 Organic micropollutants in water. Preliminary results on the haloforms and polycyclic aromatic hydrocarbons Vu Due T Huynh CK Soe.- Praeventivmed.J VOL 26, ISS 5, 1981,315-16 EFFECTS OF WORK EXPOSURES ON ORGAN SYSTEMS 2. BLOOD LUNGS ANO NERVOUS SYSTEM WALDRON HA HARRINGTON JM SCHILLING, R. S. F. (ED.). OCCUPATIONAL HEALTH PRACTICE, 2ND EDITION. XVIII+630P. BUTTERWORTHS: WOBURN, MASS., USA; LONDON, ENGLAND. ILLUS. MAPS. ISBN 0-907-33701-6.; O (0). 1981. P115-199. Monitoring individual exposure. Measurements of volatile organic compounds in breathing-sone air, drinking water, and exhaled breath Wallace L Zweidinger R Erickson M Cooper S SL 030175 00013959 AUTHOR AUTHOR SOURCE 197 TITLE AUTHOR AUTHOR SOURCE 198 TITLE AUTHOR AUTHOR SOURCE 199 TITLE AUTHOR AUTHOR AUTHOR SOURCE 200 TITLE AUTHOR AUTHOR SOURCE 201 TITLE AUTHOR SOURCE 202 TITLE AUTHOR AUTHOR AUTHOR SOURCE 1,1,1-TRICHLOROETHANE PAGE 33 m m Whitaker D Pellisrari E Environ. Int.; VOL 8, ISS 1-6, 1982,269-82 Permeation of protective garment material by liquid halogenated ethanes and a polychlorinated biphenyl Weeks RW Jr McLeod MJ DHHS (NIDSH) Publ. (U. S. U ISS 81-110,, 1981,91 pp. Permeation of protective garment materials by liquid halogenated ethanes and a polychlorinated biphenyl Weeks RW Jr McLeod MJ ACS Symp. Ser.; VOL 199, ISS Chem. Hazards Workplace: Meas. Control, 1981,235-67 Environmental pollution by a chemical waste dump Wegraan RC C Bank CA Greve PA Stud. Environ. Sci.; VOL 17, ISS Oual. Groundwater, 1981,399-57 The use of a transportable mass spectrometer for the direct measurement of industrial solvents in breath Wilson HK Ottley TW Biomed. Mass Spectrom.i VOL 8, ISS 12, 1981,606-10 Determination of volatile organics in industrial and municipal wastewaters WiIson JL Report! ISS EPA-960/3-61-07; Order No. PB82-119090,, 1981,81 pp. Upper limit for the rate of reaction of chlorinei2PJ) with methyl chloroform Wine PH Semmes DH Ravishankara AR Chem. Phys. Lett.! VOL 90, ISS 2, 1982,128-32 # m m\ } # i SL 030176 00013961 1.1,1-TRICKLOROETKANE PAGE 35 # 209 TITLE AUTHOR AUTHOR SOURCE Induction of mitotic gene conversion In strain D7 of Saccharomyces cerevisiae by 42 coded chemicals Zimmermann FK Scheel I Prog. Mutat. Res.. VOL 1, ISS Eval. Short-Term Tests Careinog.: Rep. Int. Collab. Program. 1981.461-90 END OF OFFLINE PRINT # # m m m m m ! P0093829 XXXXK*ttXXXX*K*Ktt*XXKttKtt*K*K*tt*KXXXK*XttKX*XXtt****ftXXKWKXKttXX ** * THIS IS AN OFF-LINE BIBLIOGRAPHIC CITATION LIST GENERATED BY * ** * MEDLARS II * * * N.L.M.'S NATIONAL INTERACTIVE RETRIEVAL SERVICE * ** * j 1,1,1-7RICHLOROETHANE NUMBER OF CITATIONS PRINTED = 77 THIS SEARCH WAS PERFORMED ON THE T0XBACK65 MAY 20, 1988 FILE. SORT = (ELEMENTS/DIRECTIONS GIVEN BY USER) WAS SPECIFIED O PLEASE SEND THIS LISTING TO o o o Q DIANA DANKO / PPG INDUSTRIES,INC. P.0. BOX 31 'A? BARBERTON, OHIO 44203 SL 030179 00014049 1 TITLE AUTHOR SOURCE 2 TITLE AUTHOR AUTHOR SOURCE 3 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 4 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 5 TITLE AUTHOR AUTHOR AUTHOR' AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 1,1,1-TR1CH LOROETHANE PAGE 1 Uptake of solvents in the blood and tissues of man: A review. ASTRAND I SCANO J WORK ENVIRON HEALTH; 1 (4). 1975 (RECD 1976) 199-218 Highly viscous pesticidal dispersions for spraying Battani N Geiger M Ger. Offen. PATENT NO. 2109410 10/07/71 (Schloesing S. A) Models used for the evaluation of antiarrhythmic drugs Baum T Eckfeld DK Shropshire AT Rowles G Varner LL Arch. Int. Pharmacodyn. Ther.J VOL 193i 1, 1971,149-70 ISS Integration of infrared spectrography and gas chromatography in a case of intoxication by halogenated hydrocarbon derivatives. Binaschi S Gazzaniga G Rizzo S Riva M Boll. Sco. Ital. Biol. Sper.; 45(1): 94-6, 1969 Sanitary and hygienic characteristfcs of the working conditions during use of methyl chloroform for cleaning electrical equipment. BURKATSKAYA EN TSAPK0 VG KHOKHOL'KOVA GA PLISETSKII IL KRASNYUK EP BOIKO VG PARLYUK AF GIG TR PROF ZABOL, 17 (8). 1973 41-42 030180 00014050 0 \ 6 TITLE AUTHOR AUTHOR SOURCE 7 TITLE AUTHOR AUTHOR AUTHOR SOURCE 8 TITLE AUTHOR SOURCE f 9 TITLE AUTHOR AUTHOR AUTHOR q SOURCE 10 TITLE AUTHOR AUTHOR SOURCE 11 TITLE AUTHOR AUTHOR SOURCE 12 TITLE AUTHOR Q AUTHOR SOURCE 1,1,1-TRICHLOROETHANE PAGE 2 Correlation of the cardiac sensitizing potential of halogenated hydrocarbons with their physicochemical properties Clark DG Tinston DJ Brit. J. Pharmacol.; VOL 49, ISS 2, 1973,355-7 Phenobarbital and organic solvent toxicity Cornish HH Ling BP Barth ML Amer. Ind. Hyg. Ass., J.J VOL 34, ISS 11, 1973,487-92 Solvent inhalation. CROOKE ST TEX MED! 68 (7). 1972 67-69 On the formation of phosgene by photooxidation of methy chloroform in welding. OAHLBERG JA CHRISTIANSEN VO ERIKSSON EA ANN OCCUP HYG; 16 (1). 1973 41-46 Complete analysis of Naval hyperbaric diving gases Deuel CL Roberts RM Proc. - Divers' Gas Purity Symp.J ISS AD-769 118, 1973,XII, 16 pp. DETERMINING LOW MOLECULAR WEIGHT CHLORINATED HYDROCARBONS IN WATER AND SLUDGE BY MEANS OF GAS CHROMATOGRAPHY. DIETZ F TRAUD J HUSMANN, U. (ED.). VOM WASSER, BAND 41. (ON WATER, VOL. 41). (INGER.). VIII+487P. ILLUS. VERLAG CHEMIE: WEINHEIM, WEST GERMANY. ISBN 3-527-25546-X.; 1973 (1974) (RECD 1975) 137-155 Serum ornithine carbamyl transferase os a liver response test for exposure to organic solvents. DIVINCENZO GD KRASAVAGE WJ AM IND HYG ASSOC J; 35 (1). 1974 21-29 SL 030181 000X4051 '.3 TITLE AUTHOR AUTHOR SOURCE 14 TITLE AUTHOR AUTHOR SOURCE 15 TITLE AUTHOR AUTHOR SOURCE 16 TITLE AUTHOR SOURCE 17 TITLE AUTHOR SOURCE 18 TITLE AUTHOR AUTHOR SOURCE 19 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 1,1,1-TRICH LOROETHANE PAGE 3 U Insecticide preparations based on carbarnic acid esters` Dulat ML Hennart C Ger. Offen. PATENT NO. 2250604 04/26/73 {Ciba-Geigy A.--G. ) SELECTIVE BLOCKADE OF ADRENOCEPTIVE BETA RECEPTORS IN THE HEART DUNLOP D SHANKS RG BR. J. PHARMACOL. CHEMOTHER.; VOL 32, ISS 1, 1968,201-18 Solvents in sewage and industrial waste waters. Identification and determination Ellison WK Wallbank TE Water Pollut. Control; VOL 73, ISS 6, 1974,656-72 HEPATOTOXIC POTENCY OF VARIOUS CHLORINATED HYDROCARBON VAPORS RELATIVE TO THEIR NARCOTIC AND LETHAL POTENCIES IN MICE GEHRING PJ TOXICOL. APPL. PHARMACOL.; VOL 13, ISS 3, 1968,287-98 Hepatotoxic potency of various chlorinated hydrocarbon vapours relative to their narcotic and lethal potencies in mice. Gehring PJ Toxicol. Appl. Pharmacol.', 13(31, 287-98, 1968; (REF:71 Health hazard evaluation/toxicity determination report H.H.E. 75-26-245, Babcock and Wilcox Company, Canton, Ohio Gilies D Rostand RA U. S. NTIS, PB Rep.; ISS PB-249425,, 1975,13 pp. Comparative toxicity of the principle chlorinated aliphatic solvents Gradiski D Magadur JL Baillot M Daniere MC Schuh MB J. Eur. Toxicol.! VOL 7, ISS 4, 1974,247-54 SL 030182 "J O O OI o o; oi o! oj o o o1 o 1 0| i i Oi 00014052 J^, \ 20 TITLE - AUTHOR AUTHOR SOURCE 21 TITLE AUTHOR ' '> AUTHOR AUTHOR SOURCE 22 TITLE rv 1 vy AUTHOR AUTHOR AUTHOR SOURCE O 23 TITLE AUTHOR o AUTHOR AUTHOR SOURCE o 24 TITLE AUTHOR AUTHOR , V, AUTHOR w SOURCE 25 TITLE AUTHOR AUTHOR *hy SOURCE o 1,1,1-TRICHLOROETHANE PAGE 4 vj 3 Health ha2ard evaluation/toxicity determination report 73-180/183-159, Docutel Corporation, Irving, Texas Gunter BJ Bodner A U. S. NTIS, PB Rep.; ISS PB-246470,, 1974,10 pp. Potentiation of the hepatotoxic responses to chemicals in alloxan-diabetic rats. HANASONO GK WITSCHI H PLAA GL PROC SOC EXP BIOL MED*, 149 (4). 1975 903-907 Potentiation of the hepatotoxic responses to chemicals in alloxan-diabetic rats Hanasono GK Mitschi H Plaa GL Proc. Soc. Exp. Biol. Med.; VOL 149, ISS 4, 1975,903-7 ALTERATIONS IN MITOCHONDRIAL RESPIRATORY CONTROL CHARACTERISTICS INDUCED BY 1 1 1 TRI CHLORO ETHANE HERD PA MARTIN HF FAUSTO N FED PROC! 33 C3 PART 1). 1974 608 The effect of organic solvents on erythrocytes during hypotonic hemolysis. HOLHBERG B JAKOBSON I MALMFORS T ENVIRON RES; 7 (2). 1974 193-205 Relative sensitivity of nervous functions and behavior to nonspecific effects of foreign substances Horvath M Frantik E Activ. Narv. Super.; VOL 15, ISS 1, 1973,25-7 u m 0 a & a o o o o SL 030183 o m u 00014053 26 TITLE AUTHOR SOURCE 27 TITLE AUTHOR AUTHOR SOURCE 28 TITLE AUTHOR AUTHOR SOURCE 29 TITLE -- AUTHOR AUTHOR SOURCE 30 TITLE --' AUTHOR SOURCE 31 TITLE ,\ AUTHOR AUTHOR AUTHOR AUTHOR SOURCE G - 1,1.1-TRICHLOROETHANE PAGE 5 J, ^ J'l Analysis and significance of urinary Metabolites of organic solvent Ikeda M Rinsho Kagaku; VOL 3, ISS 2, 1974,183-98 Comparative study of the excretion of Fujiuiara reaction-positive substances in urine of humans and rodents given trichloroor tetrachloro-derivatives of ethane and ethylene Ikeda M Ohtsuji H Brit. J. Ind. Med.! VOL 29, ISS 1, 1972,99-104 RELATIVE EFFECTS OF VARIOUS CHLORINATED HYDROCARBONS ON LIVER AND KIDNEY FUNCTION IN DOGS KLAASSEN CD PLAA GL TOXICOL. APPL. PHARMACOL.! VOL 10, 1967,119-31 RELATIVE EFFECTS OF VARIOUS CHLORINATED HYDROCARBONS ON LIVER AND KIDNEY FUNCTION IN MICE KLAASSEN CD PLAA GL TOXICOL. APPL. PHARMACOL.*, VOL 9, ISS 1, 1966,139-51 Preliminary study of selected potential environmental contaminants. Optical brighteners, methyl chloroform, trichloroethylene, tetrachloroethylene, and ion exchange resins Kover FD U. S. NTIS, PB Rep.J ISS PB-243910,, 1975,295 pp. HALOGENATED HYDRO CARBON SOLVENTS LONG-TERM EFFECTS AND BIOLOGICAL SAMPLING IN HUMAN BEINGS LEHNERT G MORGAN A SZA0K0WSKI D ZIELHUIS RL INT ARCH ARBEITSMED; 33 (3). 1974 251-255 O 1 ! Q G o O 1 Ol O1 ! G 1 o 1 1 o G O o su o3014 a1 i i c> : *! -^ 00014054 ~>i 1.1.1-TRICH LOROETHANE PAGE 6 o ' 32 TITLE AUTHOR \ SOURCE 33 TITLE AUTHOR '\ AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE -K 34 TITLE w' AUTHOR AUTHOR AUTHOR * AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR -*> AUTHOR AUTHOR SOURCE 35 TITLE AUTHOR AUTHOR SOURCE - 36 TITLE AUTHOR AUTHOR AUTHOR SOURCE o Dangerous chemicals reactions. 25. Liquid and gaseous oxygen Leleu J Cah. Notes Doc.! VOL 78,, 1975,119-22 Atmospheric -Fates o-f halogenated compounds Li Ilian D Singh HB Appleby A Lobban L Arnts R Gumpert R Hague R Toomey J Kazazis J et al Environ. Sci. Technol.i VOL 9, ISS 12, 1975,1042-8 Fates and levels of ambient halocarbons Lillian D Singh HB Appleby A Lobban L Arnts R Gumpert R Hague R Toomey J Kazazis J et al ACS Symp. Ser.; VOL 17, ISS Removal Trace Contain. Air, Symp., 1974, 1975,152-8 =Danger....vapor harmful2! spot-remover sniffing. Litt IF Cohen HI New England J. Med.i 281(10): 534-4, 1969! (REF:8) Quantum chemical studies of the metabolism of a series of chlorinated ethane anesthetics Loeu G Trudell J Hotulsky H Mol. Pharmacol.i VOL 9, ISS 2, 1973,152-62 SL 030185 o o o o o o o o o o o o 1 u I| ka -J . 00014055 PAGE 7 j 1,1,1-TRICHLOROETHANE Cj J 1 37 TITLE AUTHOR SOURCE 38 TITLE AUTHOR AUTHOR AUTHOR SOURCE ' 39 TITLE - AUTHOR AUTHOR SOURCE 40 TITLE AUTHOR AUTHOR * AUTHOR __ SOURCE 41 TITLE AUTHOR \ AUTHOR --1 AUTHOR SOURCE rj\ 42 TITLE w -- .. AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 43 TITLE AUTHOR AUTHOR SOURCE -- * THE EFFECTS OF PRONETHALOL AND ITS DEXTRO ISOMER UPON EXPERIMENTAL CARDIAC ARRHYTHMIAS LUCCHESI BR J. PHARMACOL. EXP. THER.; VOL 148, ISS 1, 1965,94-9 PROPRANOLOL INDERAL IN EXPERIMENTALLY-INDUCED CARDIAC ARRHYTHMIAS LUCCHESI BR WHITSITT LS BROWN NL CAN. J. PHYSIOL. PHARMACOL.; VOL 44, ISS 4, 1966,543-7 Rabbit eye irritation test: collaborative study Mareulli FN Ruggles DI J. Ass. Off. Anal. Chew.; VOL 56, ISS 4, 1973,905-14 Biodegradable analogs of DDT Metcalf RL Kapoor IP Hi rule AS Bull, who; VOL 44, ISS 1-2-3, 1971,363-74 Absorption of halogenated hydrocarbons and their excretion in breath using chlorine-38 tracer techniques Morgan A Black A Belcher DR Ann. Occup. Hyg.[ VOL 15, ISS 2-4, 1972,273-83 The absorption and retention of inhaled fluorinated hydrocarbon vapours. MORGAN A BLACK A WALSH M BELCHER DR INT J APPL RADIAT ISOT, 23 (6). 1972 285-291 Catalytic decomposition of halogenated hydrocarbons with hopcalite catalyst Musick JK Williams FW Am. Soc. Mech. Eng., [Pap.]; ISS 75-ENAs-17,, 1975,8 pp. o Oi i[ o 1 Q O i o [ o 11 o < e j o1 i i o ot i o t SL 030186 o n '*\/ *' 00014056 ' "l 44 TITLE AUTHOR AUTHOR ' AUTHOR SOURCE - 45 TITLE AUTHOR SOURCE 46 TITLE AUTHOR AUTHOR AUTHOR ' > AUTHOR SOURCE \ 47 TITLE AUTHOR AUTHOR r\ SOURCE 48 TITLE , w' AUTHOR AUTHOR SOURCE 49 TITLE AUTHOR AUTHOR SOURCE o m 1,1,1-TRICHLOROETHANE CJ PAGE S o Analysis of organic compounds In air, I, Analysis of chlorinated hydrocarbons Ohta T Makino K Mirr^uchi I Tokyo Toritsu Etsei Ktnkyusho Kenkyu Nempoi VOL 25,, 1974,347-54 Health hazards by exposure to organic solvents in domestic stain removal Okukubo A Sen*l Seihin Shohi Kagaku; VOL 16, ISS 1, 1975,5-10 Gas chromatography of chlorinated hydrocarbon in urban air Okuno T Tsuj i M Shintani Y Natanabe H Hyogo-ken Kogai Kenkyusho Kenkyu Hokoku, VOL 6,, 1974,1-6 Foraminous composition for removal of oleophilic material from the surface of water Orban J Case CE U.S. PATENT NO. 3917528 11/04/75 (Sorbent Sciences Corp.) Chlorinated Cl and C2 hydrocarbons in the marine environment Pearson CR McConnell G Proc. R. Soc. London, Ser. B! VOL 189, ISS 1096, 1975,305-32 SPECTRAL INTERACTIONS OF A SERIES OF CHLORINATED HYDROCARBONS WITH CYTOCHROME P-450 OF LIVER MICROSOMES FROM VARIOUSLY TREATED RATS. PELKONEN O VAINIO H FEBS (FED EUR BIOCHEM SOC) LETT; 51 (1). 1975 11-14 o o o o o o o o o o o o o SL 030187 o a J * 00014057 PAGE 9 1,1,1-TRICHLOROETHANE f' 1 - 50 TITLE AUTHOR AUTHOR SOURCE 51 TITLE AUTHOR AUTHOR SOURCE 52 TITLE AUTHOR AUTHOR SOURCE -- 53 TITLE AUTHOR AUTHOR AUTHOR SOURCE 54 TITLE ' _ -- AUTHOR AUTHOR SOURCE 55 TITLE AUTHOR AUTHOR AUTHOR SOURCE RELATIVE NEPHROTOXIC PROPERTIES OF CHLORINATED METHANE, ETHANE, AND ETHYLENE DERIVATIVES IN MICE PLAA GL LARSON RE TOXICOL. APPL. PHARMACOL.; VOL 7, ISS 1, 1965,37-44 Bloch.-, deal changes in rat liver in response to treatment with drugs and other agents. II. Effects of halothane, DDT, other chlorinated hydrocarbons, dimethylnitrosamine and ethionine Platt DS Cockri11 BL Biochem. Pharmacol; 18(2), 445-57, 1969! (REF!36) O o o o o BIOCHEMICAL CHANGES IN RAT LIVER IN RESPONSE TO TREATMENT WITH DRUGS AND OTHER AGENTS. II. EFFECTS OF HALOTHANE, DDT, OTHER CHLORINATED HYDROCARBONS, THIOACETAMIDE, DIMETHYLNITROSAMINE, AND ETHIONINE PLATT DS COCKRILL BL BIOCHEM. PHARMACOL.; VOL 18, ISS 2, 1969,445-57 o 0 Toxicologic analysis of expired air fn 0 , subjects employing 1-1-1 trichlorethane. PROST GH MANILLIER D GIRARD R O ARCH MAL PROF MED TRAV SECUR SOC*, 33 (4-5). 1972 197-198 PROPRANOLOL, MJ 1999, AND CIBA 39089 BA IN OUABAIN AND ADRENALINE INDUCED CARDIAC ARRHYTHMIAS RAPER C WALLE J EUR. J. PHARMACOL.; VOL 4, ISS 1, 1968,1-12 0 0 Epinephrine-induced cardiac arrhythmia potential of some common industrial solvents Reinhardt CF Mullin LS Maxfield ME J. Occup. Med.; VOL 15, ISS 12, 1973,953-5 o a | i or 'I 00014058 56 TITLE AUTHOR AUTHOR AUTHOR SOURCE 57 TITLE AUTHOR AUTHOR AUTHOR SOURCE 58 TITLE AUTHOR AUTHOR SOURCE 59 TITLE AUTHOR SOURCE 60 TITLE AUTHOR AUTHOR SOURCE 61 TITLE AUTHOR AUTHOR AUTHOR SOURCE o 1,1,1-TRICH LOROETHANE PAGE 10 HALOCARBON EPINEPHRINE INDUCED CARDIAC ARRHYTHMIA POTENTIAL OF SOME COMMON INDUSTRIAL SOLVENTS. REINHARDT CF MULLIN LS MAXFIELD ME TOXICOL APPL PHARMACOL; 22 (2). 1972 305 THE EFFECT OF CARBON TETRACHLORIDE, ADMINISTERED IN VIVO, ON THE HEMODYNAMICS OF THE ISOLATED PERFUSED RAT LIVER RICE AJ ROBERTS RJ PLAA GL TOXICOL. APPL. PHARMACOL.; VOL 11, ISS 3, 1967,422-31 Hazards from chlorinated hydrocarbon decomposition during welding. RINZEMA LC SILVERSTEIN LG AM IND HYG ASSOC J; 33 t1>. 1972 35-40 Health hazard evaluation/toxicity determination report 73-83-144, General Motors Corporation, Vandalia, Ohio Ruhe RL U. S. NTIS, PB Rep.! ISS PB-246451,, 1974,9 pp. Diagnosis of unclear poisoning through respiratory air analysis. SCHMIDT K ZORN H DTSCH MED WOCHENSCHRI 97 (40). 1972 1507-1509 The effect of maternally Inhaled trichloroethylene, perchloroethylene, methyl chloroform, and methylene chloride on embryonal and fetal development in mice end rats. SCHWETZ BA LEONG B KJ GEHRING PJ TOXICOL APPL PHARMACOL', 32 tl). 1975 84-96 030189 SL 00014059 62 TITLE AUTHOR AUTHOR AUTHOR SOURCE 63 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 64 TITLE AUTHOR AUTHOR AUTHOR SOURCE 65 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 66 TITLE AUTHOR SOURCE 1,1.1-TRICH LOR0ETHANE PAGE 11 o * 'I EFFECT OF MATERNALLY INHALED TRICHLOROETHYLENE,PERCHLOROETHYLENE,METHYL CHLOROFORM,AND METHYLENE CHLORIDE ON EMBRYONAL AND FETAL DEVELOPMENT IN MICE AND RATS SCHWETZ BA LEONG BKJ GEHRING PJ TOXICOL APPL PHARMACOL! 32:84-96,1975 Trichloro-compounds in the urine of humans exposed to methyl chloroform at sub-threshold levels. SEKI Y URASHIMA Y AIKAHA H MATSUMURA H ICHIKAWA Y HIRATSUKA F YOSHIOKA Y SHIMBO S IKEDA M INT ARCH ARBEITSMED! 34 (1). 1975 39-50 Preliminary economic impact assessment of possible regulatory action to control atmospheric emissions of selected halocarbons Shame1 RE O'Neill UK Williams R U. S. NTIS, PB Rep.; ISS PB-247115,, 1975,330 pp. Distribution of atmospheric halocarbons the air over the Los Angeles Basin. SIMMONDS PG KERRIN SL LOVELOCK JE SHAIR FH ATMOS ENVIRON; 8 t3). 1974 209-216 in Factors affecting the analysis of illicit lysergic acid diethylamide (LSD1 preparations Smit h RN J., Forensic Sci . Soc.*, VOL 14, ISS 1, 1974,33-9 o '' j4t o o 0 o o o o o o Q o SL 030190 o 00014060 '_7 TITLE AUTHOR SOURCE 68 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 69 TITLE AUTHOR AUTHOR SOURCE 70 TITLE AUTHOR AUTHOR SOURCE 71 TITLE AUTHOR SOURCE 72 TITLE AUTHOR SOURCE 1,11-TRICH LOROETHANE PAGE 12 o o ANTIARRHYTHMIC ACTIVITY OF THE BETA-ADRENERGIC BLOCKING AGENT, 1-ISOPROPY LAMINO-3- 3-TOLYLOXY-2-PROPANOL ICI 45763 SOMANI P AM. HEART J.; VOL 77, ISS 1, 1969,63-71 ANTAGONISM OF EPINEPHRINE -INDUCED CARDIAC ARRHYTHMIAS BY 42-ISOPROPYLAMINO-1-HYDROXYETHYL METHANESULFONANILIDE MJ 1999 SOMANI P FLEMING JG CHAN GK LUM BK B J. PHARMACOL. EXP. THER.i VOL 151, ISS 1, 1966,32-7 THE ANTIARRHYTHMIC ACTIONS OF BETA-ADRENERGIC BLOCKING AGENTS SOMANI P LUM BK B J. PHARMACOL. EXP. THER.; VOL 147, ISS 1, 1965,194-204 ANTIARRHYTHMIC ACTIVITY OF THE DEXTRO- AND LEVOROTATORY ISOMERS OF 42-IS0PR0PYLAMIN0-1-HY0R0XYETHYL METHANESULFONANILIDE MJ 1999 SOMANI P WATSON DL J. PHARMACOL. EXP. THER.i VOL 164, ISS 2, 1968,317-25 Experimental human exposure to methyl chloroform vapor. Stewart GayHHSchafferAWErleyDSRoweVK RD Arch. Environ. Health; 19(4)! 467-72, 1969; CREF:18) Methyl chloroform Intoxication! Diagnosis treatment. STEWART RD J AMER MED ASS! 215 (11). 1971 1789-1792 and O o o o o o 0 o SL 030191 J : * 00014061 o 1,1,1-TRICHLOROETHANE a PAGE 13 o Q 73 TITLE O AUTHOR AUTHOR AUTHOR SOURCE O 74 TITLE AUTHOR o AUTHOR AUTHOR AUTHOR AUTHOR t - SOURCE 75 TITLE AUTHOR SOURCE -- 76 TITLE AUTHOR SOURCE 77 TITLE AUTHOR AUTHOR SOURCE Toxicological hazards and properties of commonly used space structural and certain other fumigants Torkelson TR Hoyle HR Rowe VK Pest Control; 34(7): 13-18, 42-50, 1966 Cardiac sensitisation studies in dogs with myocardial infarctions Trochimowics HJ Reinhardt CF Mull in LS Asar A Karrh BW Proc. Annu. Conf. Environ. Toxicol., 5th; ISS AMRL-TR-74-125, 1974,135-44 Percutaneous absorption of organic solvents. 1). Comparative study of the in vivo percutaneous absorption of chlorinated solvents in mice Tsuruta H Ind. Health; VOL 13, ISS 4, 1975,227-36 Chlorinated hydrocarbons in the atmosphere. Analysis at the parts-pei--trillion level by GC-MS [gas chromatography-mass spectrometry] Tyson BJ Anal. Lett.; VOL 8, ISS 11, 1975,807-13 EFFECT OF VOLATILE ANESTHETICS ON ANILINE HYDROXYLASE AND AMINOPYRINE DEMETHYLASE VAN-DYKE RA RIKANS LE BI0CHEM. PHARMACOL.; VOL 19, ISS 4, 1970,1501-2 0 o c* o 0 0 0 0 0 * * * * END OF OFFLINE PRINT *#### 0 K ****** K K K K ****** K* **** K * Ktt K * K ***** K ********* K* ************ K *KP*0K0K93*4*0K0K *' * * THIS IS AN OFF-LINE BIBLIOGRAPHIC CITATION LIST GENERATED BY * ** * MEDLARS II * * N.L.M.'S NATIONAL INTERACTIVE RETRIEVAL SERVICE * * * * * ** 1,1,1-TRICHLOROETHANE NUMBER OF CITATIONS PRINTED = 26 THIS SEARCH NAS PERFORMED ON THE TOXBACK76 MAY 20, 19B6 FILE. SORT = (ELEMENTS/DIRECTIONS GIVEN BY USER) WAS SPECIFIED PLEASE SEND THIS LISTING TO DIANA DANKO / PPG INDUSTRIES,INC. P.O. BOX 31 BARBERTON, OHIO 44203 m SL 030193 00TJT3991 1,1,1-TRICHLOROETHANE PAGE 1 1 TITLE SOURCE TITLE SOURCE TITLE SOURCE TITLE SOURCE TITLE SOURCE TITLE SOURCE TITLE SOURCE TITLE AUTHOR SOURCE TITLE AUTHOR AUTHOR AUTHOR SOURCE Aerosol bomb and composition containing dimethyl ether for filling it Belg. PATENT NO. 880036 03/03/80 (Schwarzkopf Hans, G.m.b.H.) Health hazard evaluation determination report HE-78-77-659, R. L. Polk Company* Cincinnati* Ohio [USA] Report*, ISS NIOSH-TR-HHE-78-77-659; Order No. PB80-163165,, 1980,15 pp. Health hazard evaluation determination report HE 79-51-664, Gates Energy Products, Inc., Denver, Colorado Report; ISS NI0SH-HE-79-51-664; Order No. PB80-169097,, 1980,12 pp. Health hazard evaluation determination report HE 80-7-661, Jan Clopton Composition* Atlanta, Georgia Report; ISS NIOSH-HE-80-7-661; Order No. PB80169063,, 1980,8 pp. Identification and listing of hazardous wastes Fed. Regist.; VOL 45, ISS 98, 1980,33136-7 Second report of the TSCA interagency testing committee to the administrator, Environmental Protection Agency and information Dossiers on substances designated Report! ISS EPA/560/10-78/002; Order No. PB-285439,, 1978,268 pp. Standards of performance for new stationary sources; organic solvent cleaners Fed. Regist.; VOL 45, ISS 114, 1980,39766-84 Technical assistance report no. TA 80-48, Chemical Recovery Systems, Inc., Elyria, Ohio Albrecht WN Report; ISS NIOSH-HE/TA-80-48; Order No. PB81-167926,, 1980,9 pp. TOXICITY OF PER CHLORO ETHYLENE TRI CHLORO ETHYLENE 1 1 1 TRI CHLORO ETHANE AND METHYLENE CHLORIDE TO FATHEAD MINNOWS ALEXANDER HC MCCARTY Wtl BARTLETT EA BULL ENVIRON CONTAM TOXICOL,' 20 (3). 1978 344-352 SL 030194 II 10 TITLE AUTHOR SOURCE 11 TITLE AUTHOR SOURCE 12 TITLE AUTHOR SOURCE 13 TITLE AUTHOR SOURCE 14 TITLE AUTHOR SOURCE 15 TITLE AUTHOR AUTHOR SOURCE 16 TITLE AUTHOR SOURCE 1? TITLE AUTHOR AUTHOR SOURCE 1,1.1-TRICH LOROETHANE PAGE 2 Comments on the lifetimes of organic molecules in air Altshuller AP U. S. Environ. Prot. Agency, Off. Res. Dev., ERep.] EPA; ISS EPA-600/9-80-003, Proc. Conf. Methyl Chloroform Other Halocarbon Pollut.,, 1980,1/1-1/10 Characteristics of new exposure system for organic solvent Ando K Osaka-furitsu Koshu Eisei Kenkyusho Kenkyu Hokoku, Rodo Eisei Hen; VOL 18,, 1980,55-9 Reagent hazards Anon A&R; VOL 16, ISS 10, 1978,458-63 Toxic substances control. Second report of the interagency testing committee Anon Fed. Regist.t VOL 43, ISS 76, 1978,16684-8 TOXIC SUBSTAHCES CONTROL.2ND REPORT OF THE INTERAGENCY TESTING COMMITTEE ANONYMOUS FED REGIST; 43:16684-16688,1978 Health hazard evaluation determination report No. 78-96-595, Samsonite, Inc., Denver, Colorado Apol A Singal M Report; ISS NIOSH-TR-HHE-78-96-595; Order No. PB60-148141,, 1979,34 pp. Atmospheric freons and halogenated compounds Appleby A U. S. NTIS, PB Rep.; ISS PB-262432, 1976,357 pp. Comparison of chlorinated, aliphatic, aromatic, and oxygenated hydrocarbons as solvents Archer WL Stevens VL Ind. Eng. Chem. Prod. Res. Dev.; VOL 16, 4, 1977,319-25 ISS SL 030195 r' O O 0 Q a m ii 00013993 TITLE AUTHOR SOURCE TITLE AUTHOR SOURCE TITLE AUTHOR AUTHOR SOURCE TITLE AUTHOR AUTHOR AUTHOR AUTHOR ,AUTHOR SOURCE TITLE AUTHOR AUTHOR AUTHOR SOURCE TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 1,1.1-TRICHLOROETHANE PAGE 3 o Methyl Chloroform and Trichloroelhylene in the Environment Aviado DM 1976,160 pp. PRECLINICAL PHARMACOLOGY AND TOXICOLOGY OF HALOGENATED SOLVENTS AND PROPELLANTS AVIADO DM NATL INST DRUG ABUSE RES MONOGR SER; 15. 1977 CRECD 1978> 154-164 CUTANEOUS HYPER SENSITIVITY IN CASE OF OCCUPATIONAL PESTICIDE CONTACT BAJNOVA A TOMOVA L KHIG ZDRAVEOPAZ! 3 (4). 1980. 361-368. A new personal sampler for organic vapors. BAMBERGER RL ESPOSITO GG JACOBS BN POOOLAK GE MAZUR JF AM IND HYG ASSOC JJ 39 (9). 1978 701-708 SCHIZOSACCHAROMYCES POMBE: FORHARD MUTATION BARALE R PRESCIUTTINI S ROSSI AM ENVIRON MUTAGEN METHOD ANALYSIS,VOL.1.IN VITRO TESTtMUTAGENESI AMBIENTALE:METODICHE DI ANALISI,VOL.li 1:105-121,1979 Gas chromatography mass spectrometry computer analysis of volatile halogenated hydrocarbons in man and his environment. A multimedia environmental study Barkley J Bunch J Bursey JT Castillo N Cooper SD Davis JM Erickson MD Harris BS Ha Kirkpatrick M et al Biomed. Mass Spectrom,; VOL 7, ISS 4, 1980,139-47 a o o a a m m m 030196 Sb 00013994 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE TITLE AUTHOR AUTHOR AUTHOR SOURCE TITLE AUTHOR AUTHOR SOURCE TITLE AUTHOR AUTHOR AUTHOR SOURCE TITLE AUTHOR AUTHOR SOURCE 1,1,1-TRICHLOROETHANE PAGE 4 Bioconcentration ant) elimination of selected water pollutants by bluegill sunfish (Lepomis macroehirus) Barrows ME Petroeelli SR Macek KJ Carroll JJ Dyn.c Exposure Hazard Assess. Toxic Chem., tPap. Symp.]; 1930,379-92 THE IDENTIFICATION AND MEASUREMENT OF VOLATILE ORGANIC COMPOUNDS IN AQUEOUS ENVIRONMENTAL SAMPLES BELLAR TA BUDDE WL EICHELBERGER JW SCHUETZLE, DENNIS (ED.). ACS (AMERICAN CHEMICAL SOCIETY) SYMPOSIUM SERIES, NO. 94. MONITORING TOXIC SUBSTANCES. A SYMPOSIUM AT THE 174TH MEETING OF THE AMERICAN CHEMICAL SOCIETY. CHICAGO, ILL., USA, AUG. 31, 1977. XI+289P. ILLUS. AMERICAN CHEMICAL SOCIETY: WASHINGTON, D.C., USA. ISBN 0-B412-0480-2. i 1979 49-62 Comparative effects of halogenated hydrocarbon solvents on waste disposal processes Benson EN Hunter JV Proc. Ind. Waste Conf.; VOL 31,, 1977,614-27 Evaluation of an evacuated glass sampler for the analysis of volatile organic compounds in ambien t air Berg S Jacobsson S Nilsson B J. Chromatogr. Scl.i VOL 18, ISS 4, 1980,171-9 Health hazard evaluation determination report HE 80-45-688, U.S. Precision Lens,'Inc., Cincinnati, Ohio (USA) Boiano JM Burroughs GE Report; ISS NIOSH-HE-80-45-688; Order No. PB80-211543,, 1980,12 pp. SL 030197 00DW995 29 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 30 TITLE G AUTHOR SOURCE 31 TITLE o AUTHOR AUTHOR o author AUTHOR AUTHOR SOURCE o 32 TITLE G AUTHOR SOURCE 33 TITLE AUTHOR AUTHOR SOURCE 39 TITLE AUTHOR SOURCE 1,1,1-TRICHLOROETHANE PAGE 5 Q Studies on liver microsomal metabolism and interaction of vinyl chloride and related compounds in relation to possible careinogenicity Bolt HM Filser JG Hiegand M Buchter A Bolt U Proc. Int. Congr. Occup. Health, 19th! VOL 1> ISS Chem. Hazards, 1980,369-77 Prevention of soil and reservoir pollution from very dangerous technological impurities of the insecticide polychloropinene Bondarenko IB Probi. Okhr. Vod! VOL 7,, 1976,17-21 Determination of the median lethal concentration of principle chlorinated aliphatic hydrocarbons in the rat Bonnet P Franc in JM Gradiski D Raoult G Zissu D Arch. Mai. Prof. Med. Trav. Secur. Soc.! VOL 91, ISS 6-7, 1980,317-21 Determination of the biological toxicity of water-bound substances towards protozoa. I. Bacteriovorous flagellates (model organism! Entosiphon sulcatum Stein) Bringmann G Z. Wasser Abwasser Forsch.! VOL 11, ISS 6, 1978,210-15 Results of the damaging effect of water pollutants on Daphnia magna Bringmann G Kuehn R Z. Wasser Abwasser Forsch.! VOL 10, ISS 5, 1977,161-6 Chlorinated solvents in sewage works Brown D Effluent Water Treat. J.! VOL 18, ISS 3, 1978,110, 112-13, 115-17 O O ^ W o ** SL 030198 !I 000TW96 35 TITLE AUTHOR AUTHOR AUTHOR SOURCE 36 TITLE AUTHOR AUTHOR SOURCE 37 TITLE AUTHOR AUTHOR AUTHOR SOURCE 38 TITLE AUTHOR SOURCE 39 TITLE AUTHOR AUTHOR SOURCE 40 TITLE AUTHOR AUTHOR SOURCE 41 TITLE AUTHOR AUTHOR AUTHOR SOURCE 1,1,1-TRICHLOROETHANE PAGE 6 CRITICAL EVALUATION OF SAMPLING AND GAS CHROMATOGRAPHIC ANALYSIS OF HALO CARBONS AND OTHER ORGANIC AIR POLLUTANTS BRUNER F BERTONI G CRESCENTINI G J CHROMATOGR; 167. 1978 (RECD 1979) 399-407 Proceedings of the Conference on Methyl Chloroform and Other Halocarbon Pollutants, Washington, 0. C., February 27-28, 1979 IE PA-600/9-80-003] Bufalini JJ Editor 1980,209 pp. Sources of toxic pollutants found in influent to sewage treatment plants Callahan MA Ehreth DJ Levins PL Proc. Natl. Conf. Kunic. Sludge Manage., 8thI 1979,55-61 Tropospheric hydroxyl radical concentrations and methyl chloroform removal Campbell MJ U. S. Environ. Prot. Agency, Off. Res. Dev., tRep.l EPA5 ISS EPA-600/9-60-003, Proc. Conf. Methyl Chloroform Other Halocarbon Pollut.,, 1980,9/1-9/10 Crawling insect killer aerosols: A method of testing knockdown and some effects of formulation Chadwick PR Dixon K Aerosol Rep.; VOL 15, ISS 12, 1976,368-75 Analysis of global budgets of halocarbons. CHANG J5 PENNER JE ATMOS ENVIRON; 12 (9). 1978 1867-1874 Wet scrubbing of halogenated hydrocarbons Cheremisinoff PN Trattner RB Bodnarik A Spec. Conf.: Control Specific (Toxic) Pollut., [Proc.]; 1979,246-54 SL 030199 00013997 1.1,1-TRICHLOROETHANE ) PAGE 7 o 42 TITLE AUTHOR SOURCE 43 TITLE AUTHOR AUTHOR SOURCE '\ 44 TITLE AUTHOR c SOURCE 45 TITLE rh AUTHOR AUTHOR o AUTHOR AUTHOR SOURCE o 46 TITLE AUTHOR AUTHOR o AUTHOR SOURCE 47 TITLE AUTHOR AUTHOR AUTHOR SOURCE 48 TITLE # - AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE RI Solidification of leaked oils and oil leaking prevention Chikami K Japan. Kokai PATENT NO. 76 87349 07/30/76 Removal of contaminant gases from an electrolytic urine pretreatment process Colombo GV Putnam DF Am. Soc. Mech. Eng., tPap.J J ISS 77-ENAS-61,, 1977,7 pp. A LOW TOXICITY SOLVENT IN THE DETERMINATION OF URINARY ESTROGEN COOKE PR MED LAB SCI! 37 (4). 1980 (RECD. 1981). 351-354. Halogenated compound identification and Measurement in the troposphere and lower stratosphere Cronn DR Rasmussen RA Robinson E Harsch DE J. Geophys. Res.; VOL 82, ISS 37, 1977,5935-44 The impact of the chlorocarbon industry on the ozone layer Crutzen PJ Isaksen IS A McAfee JR JGR, J. Geophys. Res.; VOL 83, ISS Cl, 1978,345-63 Aerosols for cooling Daimon S Deguchi T Okamura K Jpn. Kokai Tokkyo Koho 07/10/79 (Daikin Kogyo PATENT NO. Co., Ltd.) 79 86606 Tropospheric residence times for several halocarbons based on chemical degradation via hydroxyl radicals Davis DD Matson R McGee T Heaps M Chang J Wuebbles D Prepr. Pap. Natl. Meet., Div. Environ. Chem. o o o o o & Aw m m SL 030200 ooir^^s 49 TITLE m AUTHOR AUTHOR AUTHOR SOURCE 50 TITLE AUTHOR AUTHOR SOURCE m \ 51 TITLE AUTHOR AUTHOR SOURCE 52 TITLE AUTHOR AUTHOR AUTHOR SOURCE 53 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 54 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE SL 3020l *I 1,11-TRICH LOROETHANE PAGE 8 Am. Chem. Soc.; VOL 16, ISS 1, 1976,189-91 Analysis and calibration techniques for measuring airborne particulates and gaseous pollutants Delespaul I Peperstraete H Rymen T UBS Spec. Publ. (U. S.M VOL 464,, 1977,617-23 Ozone depletion estimates for global halocarbon and fertilizer usage employing one-dimensional modelling techniques Derwent RG Eggleton AE J U. K. At. Energy Res. Establ., Rep.i 15S AERE-R 9112,, 1978,81 pp. The distribution of short-chain halogenated aliphatic hydrocarbons in some marine organisms Dickson AG Riley JP Mar. Pollut. Bull.; VOL 7, ISS 9, 1976,167-9 Animal experiments on the detection of an exposure to chemical mace. DOERING G ZOR EC-KAR LOVSEK M BERG S Z RECHTSMED; 83 (2). 1979. 105-114. Mutagenic activity in pulp mill effluents Douglas GR Nestmann ER Betts JL Mueller JC Lee EG H Stieh HF San RH C Brouses RJ P Chmelauskas AL Water Chlorination: Environ. Impact Health Eff.; VOL 3,, 1980,865-60 Tritiated thymidine uptake by the lung under low concentrations of chlorinated solvents Duprat P Bonnet P Zissu D Fabry JP Gradiski D IRCS Med. Sci.: Libr, Compend.i VOL 7, ISS 00017999 55 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 56 TITLE AUTHOR AUTHOR AUTHOR SOURCE 57 TITLE AUTHOR SOURCE 58 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE lilt1-TRICHLOROETHANE PAGE 9 5, 1979,292 A statistical study of atmospheric sampling for an enclosed inhabited environment Eaton HG Williams FW Wyatt JR OeCorpo JJ Saalfeld FE Smith DE King TL NBS Spec. Publ. (U. S.)5 VOL 519, ISS Trace Org. Anal.! Hew Front. Anal. Chem. , 1979,213-18 Determination of volatile halogenated hydrocarbons in tap water, sea water and industrial effluents by glass capillary gas chromatography and electron capture detection Eklund G Josefsson B Roos C HRC CC, J. High Resolut. Chromatogr. Chromatogr. Comraun.[ VOL 1, ISS 1, 1978,39-90 Health hazard evaluation determination report HE 77-122-695, Gould's Pumps, Inc., Seneca Falls, HY [USA] Fannick N Report; ISS NI0SH-HE-77-122-695; Order No. PB81-111239,, 1980,9 pp. POTENTIAL CONTAMINANTS INTRODUCED INTO MATER SUPPLIES BY THE USE OF COAGULANT AIDS FEIGE MA GLICK EM MUNCH JM MUNCH DJ NOSCHANG RL BRASS HJ JOLLEY, R. L., W. A. BRUNGS AND R. B. CUMMING (ED. ). HATER CHLORINATION: ENVIRONMENTAL IMPACT AND HEALTH EFFECTS, VOL. 3.! 3RD CONFERENCE, COLORADO SPRINGS, COLO., USA, OCT. 28-NOV. 2, 1979. XXVIII+1171P. ANN ARBOR SCIENCE PUBLISHERS, INC.: ANN ARBOR, MICH., USA. ILLUS. ISBN 0-250-90392-0.5 0 (0). 1980. P789-800. 030202 000^^0 59 TITLE AUTHOR AUTHOR AUTHOR SOURCE 60 TITLE AUTHOR AUTHOR AUTHOR SOURCE 61 TITLE AUTHOR SOURCE 62 TITLE AUTHOR SOURCE 63 TITLE AUTHOR SOURCE 69 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 65 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 1,1, 1-TRICH LOROETHANE PAGE 10 Organics in municipal sludges survey of forty cities Feiler HO Storch PJ Southworth R Natl. Conf. Munic. Ind. Sludge Util. Disposal. tPap.3. 1980,53-7 Fate of priority pollutants in POTW's Feiler HD Vernick AS Storch PJ Proc. Natl. Conf. Munic. Sludge Manage., 8th > 1979,72-81 Potential halogenated industrial carcinogenic and mutagenic chemicals! II. Halogenated saturated hydrocarbons. FISHBEIN L SCI TOTAL ENVIRON; 11 (2). 1979. 163-196. POTENTIAL HALOGENATED INDUSTRIAL CARCINOGENIC AND MUTAGENIC CHEMICALS. 2.HALOGENATED SATURATED HYDROCARBONS FISHBEIN L SCI TOTAL ENVIRON; 11:163-195,1979 Wasp and hornet spray composition Flanner LT U.S. PATENT NO. 9239567 11/18/80 Interactions of atmospheric pollutants, chlorine and ethylene, propene, acrolein, etc Foster P Cornu A Laffond M Massot R Roy D Comm. Eur. Communities, tRep.l EUR; ISS EUR 6621, Proc. Eur. Symp. Phys.-them. Behav. Atmos. Pollut., 1st, 1979,, 1980,226-96 Cutaneous absorption of methyl chloroform Fukabori S Nakaaki K Yonemoto J Tada 0 Rodo Kagaku; VOL 52, ISS 2, 1976,67-80 m m 030203 SL 0001400.1 O o o o 66 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 67 TITLE AUTHOR AUTHOR SOURCE 68 TITLE AUTHOR SOURCE 69 TITLE AUTHOR SOURCE 70 TITLE AUTHOR AUTHOR SOURCE 71 TITLE AUTHOR SOURCE 1,1,1-TRICH LOROETHANE PAGE 11 Air pollution by halogenated hydrocarbons. II. Chlorinated hydrocarbons. 2 Furutani C Sadayoshi K Tanabe H Hayata K Sueda A Kitakawa Y Yamaguchi-ken Kogai Senta Nenpo! VOL 5n 1979,13-17 The low-moleculai--weight fraction of PVC - a potential source for migration Gilbert J Shepherd MJ Lect. - Int.Symp. Migr., 3rd[ 1900,170-97 Health hazardevaluation/toxicity determination report number 75-147-318, Westinghouse Electric Corporation, East Pittsburgh, Pennsylvania Gilies D U. S. NTIS, PB Rep.; ISS PB-264802,, 1976,18 pp. Health hazard evaluation/toxicity determination report 77-5-362, tlatryx Company, a division of Xomox Corporation, Cincinnati, Ohio Gilies D U. S. NTIS, PB Rep.; ISS PB-273912,, 1977,10 pp. Health hazard evaluation determination report number 76-61-337, TRW Incorporated, Philadelphia, Pennsylvania Gilies D Philbin E U. S. NTIS, PB Rep.J ISS PB-273739,, 1976,16 pp. ' Exposure to solvent vapors when working with glues for upholstered furniture Gjoerloff K Inst. Vatten- Luftvardsforsk., tPubl.] B; ISS B 511,, 1979,15 pp. 030204 SL 00014002 m 72 TITLE AUTHOR m AUTHOR AUTHOR AUTHOR AUTHOR # SOURCE 73 TITLE # AUTHOR AUTHOR SOURCE # 74 TITLE m AUTHOR SOURCE 75 TITLE # AUTHOR SOURCE 76 TITLE # AUTHOR AUTHOR AUTHOR AUTHOR # SOURCE 77 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 1,1,1-TRICHLOROETHANE , PAGE 12 Comparative acute inhalation toxicity of the principal chlorinated aliphatic solvents Gradiski D fit." Wi t P Raoult 6 Magadur JL Prunein JM Arch. Hal. Prof. Med. Trav. Seeur. Soe.t VOL 39i ISS 4-5, 1978,249-57 Monitoring complex trace-gas mixtures by long-path laser absorption spectrometry Green BD Steinfeld JI Proc. Soc. Photo-Opt. Instrum. Eng., VOL 99, ISS Proc. Eur. Electro-Opt. Conf. Exhib., 3rd, 1977,32-8 Health hazard evaluation determination report No. 79-23-603, A.M.F. Head Division, Boulder, Colorado Gunter B Report; ISS NIOSH-TR-HHE-79-23-603; Order No. PB60-147135,, 1979,17 pp. Health hazard evaluation determination report HE-80-71-703, Bear Creek Uranium Company, Douglas, Hyoming tUSA] Gunter BJ Report; ISS NIOSH-HE-80-71-703; Order No. PBS1-111221,, 1980,6 pp. Health hazard evaluation determination report number 76-99-397, Redfield Company, Denver, Colorado Gunter BJ Philbin EH Lowry LK Tolos HP U. S. NTIS, PB Rep.*, ISS PB-273746,, 1977,28 pp. Ill TRI CHLORO ETHANE INTOXICATION A CASE REPORT WITH TRANSIENT LIVER AND RENAL DAMAGE REVIEW HALEVY J PITLIK S R0SENFELD J EITAN B-D CLIN TOXICOL; 16 (4). 1960. 467-472. SL 030205 00014003 o o o Q O o o o o I :^ m 70 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 79 TITLE AUTHOR SOURCE 60 TITLE AUTHOR AUTHOR AUTHOR SOURCE 01 TITLE AUTHOR AUTHOR SOURCE 02 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 83 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 1,1,1-TRICHLOROETHANE PAGE 13 Gas chromatogrephic/mass spectrometric demonstration of chlorinated aliphatic hydrocarbons in biological materials Hara K Nagata T Kishimoto E Koj ima T Nippon Hoigaku Zasshi; VOL 34, ISS 5, 1980,507-13 Evaluation of a versatile gas sampling container design Harsch DE Atmos. Environ.! VOL 14, ISS 9, 1980,1105-7 Expanded list of halogenated hydrocarbons measurable in ambient air Harsch DE Cronn DR Slater WR J. Air Pollut. Control Assoc.! VOL 29, ISS 9, 1979,975-6 Construction and testing of bulk filters with coupled gas chromatographs for determining halogen compounds in the air Hartkarap H Ionescu A Staub - Reinhalt. Luft! VOL 40, ISS 4, 1980,151-6 The occurrence of aliphatic chlorine and bromine compounds in automobile exhaust. HASANEN E SOININEN V PYYSALO H LEPPAMAKI E ATMOS ENVIRON! 13 (8). 1979. 1217-1220. Air pollution by halogenated hydrocarbons. I. Chlorinated hydrocarbons Hayata Y Furutani C Sadayoshi K Tanabe H Sueda A Ki takawa Y Yamaguchl-ken Kogal Senta Nenpo! 1978,22-31 SL 030206 # 00014004 84 TITLE AUTHOR AUTHOR AUTHOR <9 SOURCE $ 85 TITLE AUTHOR # AUTHOR AUTHOR AUTHOR SOURCE m86 TITLE m AUTHOR AUTHOR AUTHOR m AUTHOR SOURCE 87 TITLE m AUTHOR AUTHOR # AUTHOR AUTHOR SOURCE # 88 TITLE AUTHOR AUTHOR SOURCE 89 TITLE AUTHOR AUTHOR AUTHOR # AUTHOR SOURCE # 1I 1,1,1-TRICH LOROETHANE PAGE 14 Pressurized aerosol compositions Heeb 0 8ergeraarm U Frenzel CO Ger. OfFen. PATENT NO. 2849592 05/31/79 (Schwarzkopf, Hans) Gas chromatographic determination of traces of Cl- and C2-fluoro- and chlorohydrocarbons in air Hei 1 E Oeser H Hatz R Kelker H Fresenius1 Z. Anal. Chem.i VOL 297, ISS 5. 1979,357-64 ACUTE TOXICITY OF SEVERAL OIL DISPERSANTS TOWARDS THE GREEN ALGAE CHLAMYOOMONAS-REINHARDTI AND DUNALIELLA-MARINA HELDAL M NORLAND S LIEN T KNUTSEN G chemosphere; 7 (3). 1978 247-255 Acute toxicity of several oil dispersants towards the green algae Chlamydomonas and Dimal i ella Heldal M Norland S Li en T Knutsen G Chemosphere! VOL 7, ISS 3, 1978,247-55 Potentiation of insecticidal phosphoric acid esters Hennart C Blanc R Ger. Offen. PATENT NO. 2707154 09/01/77 fAirwick A.-G.) CARCINOGENICITY OF TRICHLOROETHYLENE! ARTIFACT HENSCHLER D EDER E NEUDECKER T METZLER M ARCH TOXICOL! 37:233-236,1977 FACT OR SL 030207 o . 00014005 o 1,1,1-TRICHLOROETHANE PAGE 15 o c 90 TITLE c l**l/ o Q o o o o Q -- AUTHOR AUTHOR SOURCE 91 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 92 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 93 TITLE AUTHOR SOURCE 94 TITLE AUTHOR SOURCE Hazard Evaluation and technical assistance report No. TA 76-90. Newport Industrial Products. Firestone Tire and Rubber Co.. Newport. Tennessee Hollett BA Schloemer J Report; ISS NIOSH/TA-76/90; Order No. PB-291656,> 1978,53 pp. Relationship of hydrocarbon solubility to toxicity in algae and cellular membrane effects Hutchinson TC Hellebust JA Hackav D Tam D Kauss P Am. Pet. Inst. Publ.; VOL 4308, ISS Proc. Oil Spill Conf., (Prev., Behav., Control, Cleanup), 1979,541-7 The correlation of the toxicity to algae of hydrocarbons and halogenated hydrocarbons with their physical-chemical properties Hutchinson TC Hellebust JA Tam D Mackay D Mascarenhas RA Shiu WY Environ. Sci. Res.; VOL 16, ISS Hydrocarbons Halogenated Hydrocarbons Aquat. Environ., 1980,577-86 Removal of priority pollutants by the Ou Pont PACT process Hutton DG Proc. Annu. WWEMA Ind. Pollut. Conf.! VOL 7th,, 1979,369-77 The real status of air pollution. 2. Atmospheric organic compounds in Kawasaki Ichibashi H Kanagawa-ken Taiki Osen Chosa Kenkyu Hokoku; VOL 21,, 1979,131-43 a o 0 0 0 m SL 030208 00014006 # 95 TITLE AUTHOR SOURCE 96 TITLE AUTHOR AUTHOR SOURCE 97 TITLE 0 AUTHOR AUTHOR # AUTHOR SOURCE 98 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 99 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE V? 100 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE a SL 030209 1,11-TRICHLOROETHANE PAGE 16 Mutual suppression of oxidation involved in the metabolism of thinner constituents Ikeda M DHEW Pufel. (ADM) (U. S.V, ISS ADM-79-779, Voluntary Inhalation Ind. Solvents,, 1978,322-32 Possible metabolic interaction of styrene with organic solvents Ikeda M Hirayanna T Scand. J. Work, Environ. Health; VOL 4, ISS Suppl. 2, 1978,41-6 Evaluation of GC-MS analysis for the indentification of chemical substances In fish. 4 Ito K Nakayama S Ishiguro T Nippon Kankyo Eisei Senta Shohoi VOL 7,, 1980,91-8 Organic compounds. Their interaction with and degradation of hepatic microsomal drug-metaboli2ing ensymes in vitro Ivanetich KM Lucas S Marsh JA Ziman MR Kata ID Bradshaw JJ Drug Metab. Dispos.! VOL 6, ISS 3, 1978,218-25 TERATOLOGY STUDIES IN MICE EXPOSED TO MUNICIPAL DRINKING-WATER CONCENTRATES DURING ORGANOGENESIS KAVLOCK R CHERNOFF N CARVER B KOPFLER F FOOD COSMET TOXICOL; 17:343-347,1979 Organic chemical manufacturing. Volume 8. Selected processes Key JA Stuewe CW Standifer RL Hobbs FD Pitts DM U. S. Environ. Prot. Agency, Off. Air Qual. Plann. Stand., [Tech. Rep.] EPAi ISS J^007 c O 101 TITLE (' AUTHOR AUTHOR SOURCE fi IDE TITLE AUTHOR G AUTHOR AUTHOR AUTHOR AUTHOR O SOURCE 103 TITLE C' O AUTHOR o AUTHOR AUTHOR SOURCE o 104 TITLE o AUTHOR SOURCE a 105 TITLE o -- AUTHOR AUTHOR AUTHOR SOURCE Vr ,i G 99 1,1,1-TRICH LOROETHANE PAGE 17 V e* EPA-450/3-80-028C,, 1980,363 pp. Improved aerosol propellant system Kiffel WG Grosse D Ger. Offen. PATENT NO. 2741882 03/16/78 (Johnson, S. C., and Son, Inc.) Irreversible effects of trichloroethylene exposure on the central nervous system. KJELLSTRAND P LANKE J BJERKEMO M ZETTERQVIST L MANSSON L SCAND J WORK ENVIRON HEALTH; 6 (1). 1980. 40-47. Effects of dietary polychlorinated biphenyls and polybrominated biphenyls on the renal and hepatic toxicities of several chlorinated hydrocarbon solvehts in mice. KLUWE MM HERRMANN CL HOOK JB J TOXICOL ENVIRON HEALTH; 5 (4). 1979. 605-616. Health haaard evaluation determination report number 76-24-350, Dana Corporation, Tipton, Indiana KominsKy JR U. S. NTIS, PB Rep.; ISS PB-273716,, 1976,26 pp. CHLORINATED COMPOUNDS FOUND IN HASTE TREATMENT EFFLUENTS AND THEIR CAPACITY TO BIO ACCUMULATE KOPPERMAN HL KUEHL DM GLASS GE JOLLEY, ROBERT L. (ED.). WATER CHLORINATION. ENVIRONMENTAL IMPACT AND HEALTH EFFECTS, VOL. 1. PROCEEDINGS OF THE CONFERENCE ON THE ENVIRONMENTAL IMPACT OF WATER CHLORINATION. OAK RIDGE, TENN. USA, OCT. 22-24, 1975. XVI+439P. ILLUS. ANN ARBOR SCIENCE PUBLISHERS, INC. ANN ARBOR, MICH., USA. ISBN 0-250-40201-7.; 1978 311-327 o a a a CJ ij m # SL OSORIO oooPToos o 106 TITLE o AUTHOR SOURCE a 107 TITLE AUTHOR AUTHOR SOURCE 108 TITLE a AUTHOR AUTHOR 0 SOURCE 109 TITLE AUTHOR AUTHOR SOURCE no TITLE AUTHOR AUTHOR AUTHOR 0 AUTHOR AUTHOR AUTHOR AUTHOR a SOURCE 0 0 *i 1,1, 1-TRICH LOROETHANE PAGE 18 0 EVALUATION OF PUBLIC HEALTH ASPECTS OF CARCINOGENIC MUTAGENIC BIO REFRACTORIES IN DRINKING WATER KRAYBILL HF CONFERENCE ON THE PRIMARY PREVENTION OF CANCERi ASSESSMENT OF RISK FACTORS AND FUTURE DIRECTIONS, NEW YORK, N.Y., USA, JUNE 7-8, 1979. PREV MED! 9 (2). 1980. 212-218. COMPARISON OF CONDITIONED AVOIDANCE AND UNCONDITIONED REFLEX TESTS IN RATS EXPOSED BY INHALATION TO CARBON MON OXIDE 1 1 1 TRI CHLOSO ETHANE TOLUENE OR ETHANOL KRIVANEK N MULLIN LS TOXICOL APPL PHARMACOL; 45 (1). 1978 357-358 Gas-chromatographic study on the determination of halogenated hydrocarbons in the air with special regard to modern sampling techniques Lahmann E Herzel F Spez. Ber. Kernforschungsanlage Juelich; ISS Juel-Spez-45, Organohalogenverbindungen Umwelt,, 1979,66-79 Utilization of leeches for identification of pesticides in water. LAPKINA LN FLEROV BA GIDROBIOL ZH; 16 (3). 1980 (RECD. 1981). 113-119. Structure-activity correlations of the insecticide Prolan and its.analogs Lee A Metcalf RL Williams JW Hirwe AS Sanborn JR Coats JR Fukuto TR Pestic. Biochem. Physiol.; VOL 7, ISS 5, 1977,426-36 & W W W ^j| ^ ^ W m SL 030211 o 00014009 c? 111 TITLE AUTHOR o SOURCE 112 TITLE o AUTHOR AUTHOR SOURCE 0 113 TITLE AUTHOR Q SOURCE 114 TITLE Q AUTHOR AUTHOR AUTHOR 0 SOURCE 115 TITLE 0 AUTHOR AUTHOR AUTHOR # . AUTHOR SOURCE m 116 TITLE AUTHOR SOURCE -- # 117 TITLE AUTHOR AUTHOR SOURCE 1,1,1-TRICHLOROETHANE PAGE 19 a a Dangerous chemical reactions. 64. Halogenated hydrocarbons. Part 2 Leleu MJ Cah. Notes Doc.; VOL 97,, 1979,603-34 Health hazard evaluation determination report number 76-1-388, Bohn Aluminum and Brass Corporation, Danville, Illinois Levy BS B Meyer CR U. S. NTIS, PB Rep.; ISS PB-273733,, 1977,41 pp. Molecular theory of anesthesia Lienert E Dtsch. Tieraerzt1. Wochenschr.; VOL 83, 5, 1976,198-203 ISS Gas chromatographic analysis of ambient halogenated compounds Lillian D Singh HB Appleby A J. Air Pollut. Control Assoc.; VOL 26, ISS 2, 1976,141-3 GAS CHROMATOGRAPHIC METHODS FOR AMBIENT HALO CARBON MEASUREMENTS LILLIAN D SINGH HB APPLEBY A LOBBAN LA J ENVIRON SCI HEALTH PART A ENVIRON SCI ENG; 11 (123. 1976 (RECD 1977) 687-710 Partition coefficients of blood/air and water/air for some commonly used solvents Lindquist T Int. Congr. Ser. - Excerpta Med.; VOL 440, ISS Ind. Environ. Xenobiotics, 1978,165-7 Sampling and analysis of low concentrations of organic compounds in air Lindskog A Ferm M Int. Symp. Control Air Pollut. Work. Environ., tProc.l ; VOL Part 1,, 1978,334-44 m m 0 m # 0 \ st 030212 # Q' 000140i.fi o' U O Q a Q O Q a 118 TITLE AUTHOR SOURCE 119 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 120 TITLE AUTHOR AUTHOR AUTHOR SOURCE 121 TITLE AUTHOR AUTHOR AUTHOR SOURCE 122 TITLE AUTHOR SOURCE 123 TITLE AUTHOR SOURCE 124 TITLE AUTHOR SOURCE Q 1.1,1-TRICH LOROETHANE PAGE 20 Halogenated hydrocarbons in the atmosphere Lovelock JE Ecotoxicol. Environ. Saf. ; VOL 1. ISS 3, 1977,399-406 Gases released from tissue and analysed by infrared and gas chromatography/mass spectroscopy techniques Luskus LJ Kilian HJ Lackey WW Biqgs JD J."Forensic Sci . S VOL 22, ISS 3, 1977,500-7 Background atmospheric concentrations of halogenated hydrocarbons in Japan Hakide Y Kanai Y Tominaga T Bull. Chem. Soc. Jpn.; VOL 53, ISS 9, 1980,2681-2 Gas chromatographic analysis of halogenated hydrocarbons in air over Japan Hakide Y Tominaga T Rowland FS Chem. Lett.; ISS 4, 1979,355-8 Health hazard evaluation/toxicity determination report 76-42-407, Sibley Engineering and Manufacturing Company, Sulphur Springs, Arkansas Markel HL Jr U. S. NTIS, PB Rep.; ISS PB-274227,, 1977,17 pp. SAFER SUBSTITUTES FOR XYLENE AND PROPYLENE OXIDE IN HISTOLOGY HEMATOLOGY AND ELECTRON MICROSCOPY MAXWELL MH MED LAB SCI! 35 (4). 1978 401-403 Methyl chloroform and its stabilizers Mazaleski SC U. S. Environ. Prot. Agency, Off. Res. Dev., [Rep.] EPA; ISS EPA-600/9-80-003, Proc. Conf Methyl Chloroform Other Halocarbon Pollut.,, 1980,13/1-13/11 sv 30213 l* 00014011 Q 125 TITLE AUTHOR O AUTHOR AUTHOR AUTHOR SOURCE Q 126 TITLE AUTHOR AUTHOR SOURCE 127 TITLE AUTHOR AUTHOR AUTHOR SOURCE 128 TITLE AUTHOR AUTHOR SOURCE 129 TITLE AUTHOR AUTHOR AUTHOR SOURCE 130 TITLE AUTHOR : AUTHOR SOURCE 1,1,1-TRICHLOROETHANE PAGE El & Materials balance for methyl chloroform. Level II McCartin T Phuoc L Shannon T Nagher K Report; ISS EPA-560/13-80-003; Order No. P980-175730>, 1980,300 pp. Trace organics removal by advanced wastewater treatment. MCCARTY PL REINHARO M J NATER POLLUT CONTROL FEDS 52 (7). 1980. 1907-1922. Organics removal by advanced wastewater treatment McCarty PL Reinhard M Argo DG Proc. - AWWA Annu. Conf., 97thS VOL 1,, 1977,5-3, 26 pp. Methyl chloroform! impact on stratospheric ozone McConnell JC Schiff HI Science; VOL 199, ISS 4325, 1978,174-7 Health hazard evaluation project No. HE-79-49-631, Dana Corporation-Spicer Universal Joint Division, 400 South Miller Avenue, Marion, Indiana 46952, [USA] McOuilkin SD Singal M Shea L Report; ISS NIOSH-HE-79-49-631; Order No. PB80-195290,, 1979,25 pp. Pollution components in the air in printing workshops Moelhave L Baelum J Ugeskr. Laeg.S VOL 141, ISS 46, 1979,3187-92 u # m 0 SL 03021* 00014012 o o r> U O O' O o o o o o * J 131 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 132 TITLE AUTHOR AUTHOR SOURCE 133 TITLE AUTHOR AUTHOR SOURCE 134 TITLE AUTHOR AUTHOR SOURCE 135 TITLE AUTHOR AUTHOR SOURCE 136 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE o o 1,1,1-TRICHLOROETHANE PAGE 22 Smog forming hydrocarbons in urban air Mulcahy MF R Nelson PF Smith NY Hurray KE Whitfield FB Occurrence Control Photochem. Pollute Proc. Symp. Workshop Sess.i 1976>Paper No. IV, 17 pp. Enhanced activity of liver drug-metabolizing enzymes for aromatic hydrocarbons and chlorinated hydrocarbons following food deprivation. NAKAJIHA T SATO A TOXICOL APPL PHARMACOL! 50 (3). 1979. 549-556. Environmental fate of methyl chloroform Neely HB Agin G U. S. Environ. Prot. Agency, Off. Re3. Dev.> CRep.l EPA; ISS EPA-600/9-80-003, Proc. Conf. Methyl Chloroform Other Halocarbon Pollut.,, 1980,3/1-3/21 Respirator cartridge efficiency studies! VI. Effect of concentration. NELSON GO HARDER CA AM IND HYG ASSOC J; 37 (4). 1976 205-216 Glove permeation by organic solvents Nelson GO Wong CM Report! ISS UCID-17758,, 1978,13 pp. MUTAGENICITY OF CONSTITUENTS IDENTIFIED IN PULP AND PAPER MILL EFFLUENTS USING THE SALMONE LLA/MAMMALIAN-MICROSOME ASSAY NESTMANN ER LEE EG-H MATULA TI DOUGLAS GR MUELLER JC MUTAT RES; 79:203-212,1980 m m m m m SL 030215 S3 a 00014013 137 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 138 TITLE AUTHOR AUTHOR SOURCE 139 TITLE AUTHOR AUTHOR AUTHOR SOURCE 140 TITLE AUTHOR AUTHOR AUTHOR SOURCE 141 TITLE AUTHOR AUTHOR AUTHOR SOURCE- 142 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 1,1,1-TRICH LOROETHANE PAGE S3 Mutagenicity of constituents identified in pulp and paper mill effluents using the Salmonelia/mammalian-microsome assay Hestmann ER Lee EG H Matula TI Douglas GR Mueller JC Mutat. Res.! VOL 79, ISS 3, 1980,203-12 The Influence of organic solvents on cytochrome P-450-mediated metabolism of biphenyl and benzol a)pyrene Hilsen OG Toftgaard R Microsomes, Drug Oxid., Chem. Card*nog., tint. Symp. Microsomes Drug Oxid.l, 4th! VOL 2,, 1980,1235-8 BIOSTATISTICS OF AMES-TEST DATA NORPOTH K REISCH A HEINECKE A SHORT-TERM TEST SYST DETECT CARCIN06 PROC SYMPi1978)i 312-322,1980 The determination of organic species In the telephone central office ambient Oblas 0 Dugger 0 Lieberman S Electr. Contacts: VOL 25th,, 1979,35-9 The determination of organic species in the telephone central office ambient Oblas 0W Dugger DL Lieberman SI IEEE Trans. Components, Hybrids, Manuf. Technol.> VOL CHMT-3, ISS 1, 1980,17-20 Influence of industrial solvents on the balance system - an experimental animal model Odkvist LM Larsby B Hyden D As chan G Tham R Int. Symp. Control Air Pollut. Work. Environ., CProe.3> VOL Part 2>> 1978,76-87 030216 SL II o 00014014 143 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 144 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 145 TITLE AUTHOR o AUTHOR AUTHOR SOURCE o 146 TITLE AUTHOR AUTHOR AUTHOR SOURCE 147 TITLE AUTHOR AUTHOR SOURCE Q 1,1,1-TRICHLOROETHANE PAGE 24 ON THE MECHANISM OF VESTIBULAR DISTURBANCES CAUSED BY INDUSTRIAL SOLVENTS ODKVIST LM LARSBY B THAM R ASCHAN G STAHLE, J. (ED.). ADVANCES IN OTO-RHINO-LARYNGOLOGY, VOL. 25. FRONTIERS IN VESTIBULAR AND OCULO-MOTOR RESEARCH; BARANY SOCIETY ORDINARY MEETING, UPPSALA, SWEDEN, JUNE 1-3, 1978. X+226P. S. KARGER: BASEL, SWITZERLAND; NEW YORK, N.Y., USA. ILLUS. ISBN 3-8055-2988-0.', 0 (0). 1979. P167-172. On the mechanism of vestibular disturbances caused by industrial solvents Oedkvist LM Larsby B Thatn R Aschan G Adv. Oto-Rhino-Laryngoi.> VOL 25, ISS Front. Vestibular Oculo-Mot. Res. , 1979,167-72 Aliphatic chlorinated hydrocarbons transferred from contaminated water Into fishes Ogino Y Ishida T Ogata M Okayama-ken Kankyo Hoken Senta Nempoi VOL 1>> 1977,133-5 Local distribution of chlorinated hydrocarbons in the ambient air in Tokyo. OHTA T MORITA M MIZOGUCHI I ATMOS ENVIRON; 10 (7). 1976 557-560 Analysis by Roach's theory on accumulation of organic chloride solvents in fish Osaki H Ogata H Igaku To Seibutsugaku! VOL 94, ISS 6, 1977,537-41 i , *1 SL 030217 00014015 r-8 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 149 TITLE AUTHOR SOURCE 150 TITLE AUTHOR AUTHOR SOURCE 151 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 152 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 1,1,1-TRICH LOROETHANE PAGE 25 Chloroethanes: review of toxicity Parker JC Casey GE Bahlman LJ Lei del NA Rose D Stein HP Thomas AW Lane JM Am. Ind. Hyg. Assoc. J., VOL 40, ISS 5, 1979,A-46, A-48, A-50, A-52-A-6Q Quantification of chlorinated hydrocarbons previously collected air samples Pellizsari ED Report} ISS EPA/450/3-78/112; Order No. PB-289804,, 1978,151 pp. in Health hazard evaluation determination report HE 79-42-685, Motion Picture Screen Cartoonists Local 841, 25 West 43rd Street, New York, New York 10036, CUSA1 Peter 0 Edelbrock D Report; ISS NIOSH-HE-79-42-685*, Order No. PB80-211534,, 1980,13 pp. Hydrocarbon reactivity and the role of hydrocarbons, oxides of nitrogen, and aged smog in the production of photochemical oxidants Pitts JN Jr Winer AM Carnal1 KR Lloyd AC Ooyle GJ U. S. Environ. Prot. Agency, Off. Res. Dev., CRep.3 EPAS ISS EPA-600/3-77-001b, Int. Conf. Photochem. Oxid. Pollut. Control Proc.t Vol. 2; PB-264 233,, 1977,687-704 Study of leucine ami nopeptidase (LAP) and alkaline phosphatase in workers in the production of monochloroacetic acid Popovski P Orusev T Bauer S Gruev T Bogdanova M Hrisoho R God. Zb. Med. Fak. Skopje; VOL 25,, 1979,163-7 SL 030218 00014016 153 TITLE AUTHOR AUTHOR SOURCE 154 TITLE AUTHOR AUTHOR SOURCE 155 TITLE AUTHOR SOURCE 156 TITLE AUTHOR AUTHOR AUTHOR SOURCE 15^ TITLE AUTHOR AUTHOR SOURCE 158 TITLE AUTHOR AUTHOR SOURCE 1,1,1-TRICHL0R0ETHANE PAGE 26 HALO ETHYLENE RELATED COMPOUNDS OF INDUSTRIAL ENVIRONMENTAL AND MEDICAL SIGNIFICANCE POSNER HS FALK HL ENVIRON HEALTH PERSPECT; (21). 1477 (RECD 1978) 293-326 Hepatic function after acute or subchronic nicotine administration in untreated mice and mice treated with hepatotoxic chemicals. PRIESTLY BG PLAA GL ARCH INT PHARMACOOYN THER! 223 (1). 1976 (RECD 1977) 132-141 Health hazard evaluation determination report no. HE 78-79-736, Cissell Manufacturing Company, Louisville, Kentucky Pryor P Report! ISS NI0SH-HE-78-79-736! Order No. PB81-170870,, 1980,21 pp. Characterization of preparation plant wastewaters Randolph KB Kay LB Smith RC Jr U. S. Environ. Prot. Agency, Off. Res. Dev., CRep.) EPA; ISS EPA-600/7-79-098b Proc. : Symp. Coal Clean. Achieve Energy Environ. Goals, Vol. 2, 1978S PB 299384,, 1979,824-55 Toxicity removal in textile plant waste waters Rawlings GO DeAngelis OG J. Am. Leather Chem. Assoc.; VOL 74, ISS 11, 1979,404-17 Toxicity of secondary effluents from textile plants Rawlings GO Samfield M U. S. Environ. Prot. Agency, Off. Res. Dev., tRep.l EPA," ISS EPA-600/7-78-168, Syntp. Proc. Process Meas. Environ. Assess., 1978; PB-290 331,, 1979,153-69 SL 030219 m 00014017 m m 159 TITLE AUTHOR m AUTHOR SOURCE m 160 TITLE AUTHOR AUTHOR SOURCE m 161 TITLE AUTHOR m AUTHOR SOURCE 162 TITLE m AUTHOR SOURCE 163 TITLE m AUTHOR AUTHOR SOURCE m 164 TITLE AUTHOR SOURCE 165 TITLE AUTHOR AUTHOR m AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR 1,1,1-TRICH LOROETHANE PAGE 27 BIO ACCUMULATION OF ANTHROPOGENIC TOXINS IN THE ECOSYSTEM RAY SM TRIEFF NM TRIEFF, N. M. CEO.). ENVIRONMENT AND HEALTH. X+652P. ANN ARBOR SCIENCE PUBLISHERS, INC.: ANN ARBOR, MICH., USA. ILLUS. ISBN 0-250-40275-0.! 0 EO). I960. P93-120. Odor detection and respirator cartridge replacement Reist PC Rex F J., Am. Ind. Hyg. Assoc.i VOL 38, ISS 10, 1977,563-6 Percutaneous absorption of solvent vapors in man. RIIHIMAKI V PFAFFLI P SCAND J WORK ENVIRON HEALTH; 4 (1). 1978 73-85 Health hazard evaluation determination report number 74-129-268, General Electric Company, Waynesboro, Virginia Roper P U. S. NTIS, PB Rep.; ISS PB-273712,, 1976,34 pp. DETERMINING THE ONA-MODIFYING ACTIVITY OF CHEMICALS USING DNA POLYMERASE-DEFICIENT ESCHERICHIA COLI ROSENKRANZ HS LEIFER Z CHEM MUTAGENS:PRIN METHODS THEIR DETECTION; 6:109-147,1980 CARDIO VASCULAR DISEASE AND ENVIRONMENTAL EXPOSURE ROSENMAN K0 BR J IND MED; 36 (2). 1979. 85-97. Environmental and health aspects of selected organohalide compounds: an information overview Ross RH Yeatts LB Jr Lewis EB Dailey GA Harnden OS Michelson DC Frogge LM SL 030220 00014018 SOURCE 166 TITLE AUTHOR AUTHOR SOURCE 167 TITLE AUTHOR AUTHOR AUTHOR SOURCE 168 TITLE AUTHOR AUTHOR AUTHOR SOURCE 169 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 170 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 171 TITLE AUTHOR AUTHOR SOURCE 1,1,1-TRICHLOROETHANE PAGE 28 Report! ISS 0RNL/EIS-1Q5,, 1978,512 pp. Investigation of organic contamination of ground water in South Brunswick Township, New Jersey, USA. ROUX PH ALTHOFF HF GROUND MATER*, 18 (5). 1980. 464-471. The trace composition of the atmosphere and the global atmospheric ozone content Roy CR Galbally IE Fraser PJ Biogeochem. Ancient Nod. Environ., Proc. Int. Symp., 4th; 1980,395-403 Synthesis and fungicidal activity of diaryl 1,1-dichloroethylphosphonates Roy NK Lalljee B Bedi S Agric. Biol. Chem.J VOL 44, ISS 12, 1980,2995-7 Performance testing of the NIOSH charcoal tube technique for the determination of air conditions of organic vapors. SAALWAECHTER AT MCCAMMON C S JR ROPER CP CARLBERG KS AM INO HYG ASSOC J; 38 (9). 1977 476-486 AN INVESTIGATION OF THE DECHLORINATION OF A SERIES OF HALO ALKANES BY RAT LIVER MICROSOMES AND ITS POSSIBLE ROLE IN THE EXPRESSION OF TOXIC PHENOMENON SALMON AG MACKRODT WC JONES RB BASU SK ASHBY J TOXICOL APPL PHARMACOL; 45 (1). 1978 327-328 A structure-activity relationship of some chlorinated hydrocarbons Sato A Nakajima T Arch. Environ. Health; VOL 34, ISS 2, 1979,69-75 SL 030221 00014019 m m\ m 172 TITLE AUTHOR AUTHOR SOURCE 173 TITLE AUTHOR AUTHOR AUTHOR SOURCE 174 TITLE AUTHOR AUTHOR SOURCE 175 TITLE AUTHOR AUTHOR SOURCE 176 TITLE AUTHOR SOURCE 177 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 1,1,1-TRICHLOROETHANE PAGE 29 Enhanced activity of liver drug-metabolizing enzymes following chronic ethanol consumption and starvation Sato A Nakajima T Proc. Int. Congr. Occup. Healthi 19th; VOL 1* ISS Chem. Hazards* 1980*645-51 Results of the tests of a chemical-physical process combination for wastewater experiments on a large scale Scherb K Klingl H Mayer E Muench. Beltr. Abwasser-* Fisch.- Flussbiol.* VOL 29* ISS Mod. Abwasserreinigungsverfahren* 1978,135-48 Determination of organic pollutants by gas chromatography after cryogenic sampling Seifert B Ullrich 0 Stud. Environ. Scl . * VOL 1* ISS Atmos. Pollut., 1978,69-72 Elevated ozone concentrations measured downwind of the Chicago-Gary urban complex Sexton K Westberg H J. Air Pollut. Control Assoc.* VOL 30* ISS 8, 1980,911-14 Effect of chronic exposure to low concentrations of chlorinated ethane series hydrocarbons on the specific and nonspecific immunological response in animal experiments Shmuter LM Gig. Tr. Prof. Zabol.5 ISS 8, 1977,38-43 Smog chamber studies of the reactivity of volatile organic compounds Sickles JE II Wright RS Sutcliffe CR Blackard AL Dayton DP Proc.* Annu. Meet. - Air Pollut. Control Assoc.*, VOL 73rd, ISS 4, 1980,Paper 80-50.1, 16 pp. 030222 SL 00019020 o ' `i 178 TITLE ) AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 179 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 180 TITLE AUTHOR AUTHOR SOURCE 181 TITLE AUTHOR AUTHOR AUTHOR SOURCE 182 TITLE AUTHOR AUTHOR AUTHOR SOURCE j A 1,1,1-TRICH UOROETHANH PAGE 30 Generation of volatile organic compounds from nonvolatile precursors in water by treatment with chlorine or ozone Sievers RE Barit.ley rm Eiceman GA Haaek LP Shapiro RH Walton HF Hater Chlorination! Environ. Impact Health Eff., Proc, Conf.i VOL 2,, 1978,615-29 Gas chromatographic and mass spectrometric analysis of volatile organics in the atmosphere Sievers RE Barkley Rtl Jr Denney DW Harvey SO Roberts JM Bollinger MJ Delany AC ASTM Spec. Tech. Publ.; VOL 721, ISS Sampling Anal. Toxic Org. Atmos., 1980,3-21 Hemodynamic effects of aerosol propellants! III. Vascular resistance in the canine hind limb. SIMAAN JA AVIAOO DM TOXICOLOGY; 5 (3). 1976 287-295 MUTAGENIC ACTIVITY OF CHEMICALS IDENTIFIED IN DRINKING WATER SIMMON VF KAUHANEN K TARDIFF RG DEV TOXICOL ENVIRON SCI; 2:299-258,1977 Mutagenic activity of chemicals identified in drinking water Simmon VF Kauhanen K Tardiff RG Dev. Toxicol. Environ. Sci.; VOL 2, ISS Prog. Genet. Toxicol., 1977,299-58 W ^ A o SL 030223 0 00014021 183 TITLE AUTHOR AUTHOR AUTHOR SOURCE 184 TITLE AUTHOR SOURCE 165 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 166 TITLE AUTHOR AUTHOR AUTHOR SOURCE 187 TITLE AUTHOR AUTHOR AUTHOR SOURCE 188 TITLE AUTHOR AUTHOR SOURCE 1,1,1-TRICHLOROETHANE PAGE 31 Continuous end ultrasensitive apparatus for the measurement of air-borne tracer substances Si wmtonds PG Lovelock AJ Lovelock JE J. Chromatogr.*, VOL 126,, 1976,3-9 Atmospheric halocarbons evidence in favor of reduced average hydroxyl radical concentration in the troposphere Singh HB Geophys. Res. Lett.I VOL 4, ISS 3, 1977,101-4 Fate of halogenated compounds in the atmosphere - interim report 1977 Singh HB Salas LJ Shiegeishi H Smith AH U. S. NTIS, PB Rep.! ISS PB-278198,, 1978,65 pp. Halogenated trace constituents in the global atmosphere Singh HB Salas LJ Shigeishi H U. S. Environ. Prot. Agency, Off. Res. Dev. [Rep.] EPA; ISS EPA-600/9-80-003, Proc. Conf. Methyl Chloroform Other Halocarbon Pollut.,, 1980,4/1-4/15 Aeration (plus resins) doing job removing TOC Singley JE Ervin AL Mi Hi amson DF Water Sewage Works; VOL 126, ISS 9, 1979,100-2 IN-VITRO COMPARATIVE BIO ACTIVATION OF ALIPHATIC HALOGENATED HYDRO CARBONS SIPES IG GANBOLFI AJ 2ND INTERNATIONAL CONGRESS ON TOXICOLOGY, BRUSSELS, BELGIUM, JULY 6-11, 1980. TOXICOL LETTERS (AMSTU 0 (SPEC. ISSUE 1). 1980. 33. 03022*  T* aa # o 00014022 -/ 189 TITLE AUTHOR ' `\ AUTHOR -.y' SOURCE 190 TITLE AUTHOR AUTHOR AUTHOR SOURCE 191 TITLE AUTHOR AUTHOR ,SOURCE 192 TITLE AUTHOR SOURCE 193 TITLE AUTHOR SOURCE 194 TITLE AUTHOR AUTHOR SOURCE 195 TITLE .y 'y AUTHOR AUTHOR AUTHOR SOURCE 1,1)1-TRICHLOROETHANE PAGE 32 In vitro comparative bioactivation of aliphatic halogenated hydrocarbons Sipes IG Gandolfi AJ Dev. Toxicol. Environ. Sci.i VOL 8> ISS Mech. Toxic. Hazard Eval. 1980,501-6 Study of removal processes for halogenated air pollutants Snelson A Butler R Jarke F Report! ISS EPA/600/3-78/058! Order No. PB-284056,, 1978,118 pp. Use of high performance liquid chromatography and thin layer chromatography in the rapid detection of human cellular toxicity of environmental substances Solomons CC McDermott N Trace Subst. Environ. Health; VOL 12,, 1978,447-54 Houston aerosol characterization - GC/MS study. I Sparacino CM Spec. Conf. Ozone/Oxid.: Interact. Total Environ., CProc.l, 2nd; 1979,234-46 Determination of purgeable organics In sediment Speis ON Environ. Sci. Res.; VOL 16, ISS Hydrocarbons Haloqenated Hydrocarbons Aquat. Environ., 1980,201-6 Oxidation of chlorinated ethanes Spence JW Hanst PL J. Air Pollut. Control Assoc.! VOL 28, ISS 3, 1978,250-3 Gas chromatography-mass spectrometry identification of trace organics in Philadelphia, Pennsylvania, USA, drinking waters during a 2-year period. SUFFET IH BRENNER L CAIRO PR WATER RES! 14 (7). 1980. 853-867. 1i m \; i 91 t Li aa 00014023 196 TITLE AUTHOR AUTHOR SOURCE 197 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 198 TITLE .AUTHOR AUTHOR SOURCE 199 TITLE AUTHOR SOURCE 200 TITLE AUTHOR SOURCE 201 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 1,1,1-TRICHLOROETHANE PAGE 33 Health hazard evaluation determination Report No. HE 78-35-568, American Broadcasting Companies, Inc., New York, New York Taft RM Haring MK Reports ISS NI0SH-HE-78-35-568S Order No. PB81-150450,, 1979,18 pp. Differential reinforcement of low rate. 2. Effects of methyl chloroform Tainaka H Kitagawa M Kosaka H Tabuchi T Ando K Ishibashi T Osaka-furitsu Koshu Eisei Kenkyusho Kenkyu Hokoku, Rodo Eisei HenS VOL 14,, 1976,1-5 An analysis of halocarbons in the air of several working and living environments Taketomo AP Grimsrud E Proc. Mont. Acad. Sci.i VOL 37,, 1978,128-34 Adsorption capacity of trapping column packed with porous polymer beads Tanaka T KogaiS VOL 13, ISS 3, 1978,142-6 Chromatographic characterization of porous polymer adsorbents in a trapping column for trace organic vapor pollutants in air. TANAKA T J CHROMATOGR S 153 (1). 1978 7-14 Cardiac depression by haloalkane propellants, solvents, and inhalation anesthetic in rabbits. TAYLOR GJ DREW RT LORES E H JR CLEMMER TA TOXICOL APPL PHARMACOL! 38 (2). 1976 379-387 SL 030226 i * ! 00014024 1,1,1-TRICHLOROETHANE PAGE 34 V'Z TITLE AUTHOR AUTHOR -- AUTHOR AUTHOR SOURCE 203 TITLE AUTHOR AUTHOR AUTHOR SOURCE 204 TITLE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 205 TITLE --' AUTHOR AUTHOR SOURCE 206 TITLE AUTHOR AUTHOR SOURCE The sampling of organic vapors using activated charcoal Teass AW MeCommon CS Roper CP Saalwaechter AT Hew Publ. (NIOSH) (U. S.)! VOL 76-193, ISS NIOSH Solid Sorbents Roundtable, 2nd, 1973, 1976,55-73 CENTRIZONAL NECROSIS OF THE LIVER FROM ALPHA TRI CHLORO ETHANE FOLLOWED BY CHRONIC ACTIVE LIVER DISEASE WITH RECOVERY AND BUDD CHIARI SYNDROME TEXTER EC GRUNOW WA ZIMMERMAN HJ 52NO ANNUAL MEETING OF THE CENTRAL SOCIETY FOR CLINICAL RESEARCH, CHICAGO, ILL., USA, NOV. 1-3, 1979. CLIN RES! 27 (4). 1979. 684A. Pharmacokinetics of solvents in the experimental animal model Than, R Larsby B Hyden D Aschan G Odkvist LM Int. Symp. Control Air Pollut. Work. Environ., EProc.I! VOL Part 2,, 1978,88-9B Interest in the study of gas chromatography in certain criminal investigations Thoset H David JJ Bull. Med. Leg., Urgence Med., Cent. Anti-Poisons! VOL 20, ISS 3, 1977,201-4 BIO TRANSFORMATION OF ORGANIC SOLVENTS A REVIEW TOFTGARD R GUSTAFSSON J-A SCAND J WORK ENVIRON HEALTH! 6 (1). 1980. 1-18. 9 9 9 S SL 030227 o 1 o j r 11 00019025 0 0 07 TITLE AUTHOR SOURCE 0 08 TITLE m AUTHOR SOURCE 209 TITLE 0 0 L) AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 210 , TITLE 0 AUTHOR AUTHOR AUTHOR SOURCE 211 TITLE ' AUTHOR AUTHOR AUTHOR SOURCE -- 12 TITLE AUTHOR SOURCE 1,1,1-TRICHLOROETHANE PACE 35 Damage of stratospheric ozone by halocarbons Tominaga T Sendai Kagaku! VOL 85,, 1978,36-7 DO INDUCED SPERM-HEAD ABNORMALITIES IN MICE SPECIFICALLY IDENTIFY MAMMALIAN MUTAGENS RATHER THAN CARCINOGENS TOFHAM JC MUTAT RES; 79:379-387,1980 Early experimental demonstration of the hepatoxicity of some chlorinated solvents by the study of the synthesis of hepatic DNA Truffert L Girard-Nallon C Emmerich E Neauport C Ripault J Arch. Mai. Prof. Med. Trav. Secur. Soc.; VOL 38, ISS 1-2, 1977,261-3 Evaluation of hepatocytes isolated by a nonperfusion technique in a prescreen for cytotoxicity. TYSON CA MITOMA C KALIVODA J J TOXICOL ENVIRON HEALTH! 6 (1). 1980. 197-205. COMPARISON BETWEEN THE ACUTE TOXICITY OF 1 1 1 TRI CHLORO ETHANE AND 112 TRI CHLORO ETHYLENE VAINIO H PFAFFLI P SAVOLAINEN H BURFORD, R. G. INTERNATIONAL CONGRESS ON TOXICOLOGY. ABSTRACTS. TORONTO, ONTARIO, CANADA. 52P. INTERNATIONAL CONGRESS ON TOXICOLOGY: TORONTO, ONTARIO, CANADA.! 1977 26 Waste gas in the enameling plant concentration of dust and gas-form emissions. maximum occupational-exposure values and their control Van der Rhee A Mitt. Ver. Dtsch. EmaiIfachleute! VOL 26, ISS 11, 1978,199-55 0 m 0 0 0 0 0 0 0 030228 SL 00014026 213 TITLE AUTHOR SOURCE 214 TITLE AUTHOR SOURCE 215 TITLE AUTHOR AUTHOR SOURCE 216 TITLE AUTHOR SOURCE 217 TITLE AUTHOR SOURCE 218 TITLE AUTHOR SOURCE 219 TITLE AUTHOR AUTHOR SOURCE 1.1. 1-TRICHLOROETHANE PAGE 36 Dechlorination mechanisms of chlorinated olefins. VanDyke RA Environ, Health Perspect. 21! 121-124 1977 (22 References) Mining health hazard evaluation HHE 79-101-105 weld shop Vegella T Report! ISS NIOSH-TR-HHE-79-101-105, OrderHo. PBBO-149628,. 1979,13pp. Comparative percutaneous toxicity of ten industrial solvents in the guinea pig. Wahlberg JE Boman A Scand. J. Work Environ. Health 5(4): 345-351 1979 (18 References) A critical review of (chlorine oxide )x and (bromine oxide)x rate constant data of atmospheric importance Watson RT NASA (Contract. Rep.) CR! ISS NASA-CR-154106, Int. Conf. Probl. Relat. Stratos., 1976.. 1977,20-9 Insecticidal compositions Williams DE Brit. PATENT NO. 1438941 06/09/76 (Thompson and Capper Ltd.) Low-combustibility propellant for aerosols Wittenhorst AJ M Belg. PATENT NO. 869336 11/16/78 (Von Treu A.-G. ) Gas filter testing. Theoretical considerations on the separating capacity of adsorbents Wolf 0 Fahrbach J Staub - Reinhalt. Luft i VOL 36, ISS 1, 1976,39-43 030229 SL *t 00014027 lilt1-TRICHLOROETHANE PA6E 37 m 220 TITLE AUTHOR AUTHOR AUTHOR SOURCE 221 TITLE AUTHOR AUTHOR AUTHOR AUTHOR SOURCE 222 TITLE AUTHOR SOURCE 223 TITLE AUTHOR SOURCE 224 TITLE AUTHOR SOURCE 225 TITLE AUTHOR AUTHOR SOURCE 226 TITLE AUTHOR AUTHOR SOURCE INTERACTIONS BETWEEN ETHANOL AND INHALED 1 1 1 TRI CHLORO ETHANE IN MICE WOOLVERTON WL PROSS RS BALSTER RL 64TH ANNUAL MEETING OF THE FED. AM. SOC. EXP BIOL.i ANAHEIM, CALIF., USA, APR. 13-18, 1980. FED PROC; 39 (3). 1980. ABSTRACT 1333. Energy and solvent efficiencies of dual-bed carbon adsorption facilities Wynne RG Spencer LP Hughes DE Stanley KL Proc., Annu. Meet. - Air Pollut. Control Assoc.i VOL 73rd, ISS 3, 1980,Paper 80-34.3, 15 pp. Removal of organic solvent from waste gas Yamauchi F Jpn. Kokai Tokkyo Koho PATENT NO. 78147693 12/22/78 (Nippon Electric Co., Ltd.) Chlorinated ethanes and ethylenes in insecticide formulations Yonezawa T Japan. Kokai PATENT NO. 76 48436 04/26/76 (Yonezawa Chemical Industry Co., Ltd.) Priority pollutants in municipal wastewaters Young OR Annu. Rep. - South. Calif. Coastal Water Res Pro).; 1978,103-12 MYO CARDIAL AND HEMODYNAMIC EFFECTS OF N0NFLU0RINATED HYDRO CARBONS ZAKHARI S AVIADO DM PHARMACOLOGIST; IS (2). 1976 247 Recovery of solvents from waste gases Zucker J Rechnitz G Swiss PATENT NO. 588884 06/15/77 (Technochemie A.-G. Maschinenfabrik ) * * * * END OF OFFLINE PRINT ***** m # P0090231 ttttKKK*K**KKK*KK****K**K*K*****K**tt*Ktt*tt****K***********ttKK*K******K*** ** * THIS IS AN OFF-LINE BIBLIOGRAPHIC CITATION LIST GENERATED BY * #* * MEDLARS II * ** # N.L.M.'S NATIONAL INTERACTIVE RETRIEVAL SERVICE * # * *# O o 1,1,1-TRICHLOROETHANE NUMBER OF CITATIONS PRINTED = 2 THIS SEARCH WAS PERFORMED ON THE SOILINE SORT WAS NOT REQUESTED ^ Milliner MAY 20, 1986 FILE. o o PLEASE SEND THIS LISTING TO o o o o DIANA DANKO / PPG INDUSTRIES,INC. P.O. BOX 31 BARBERTON, OHIO 49203 o SL 030231 O o o ') H ft 00013746 1,1,1-TRICHLOROETHANE PAGE 1 1 UNIQUE IDENTIFIER AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION COUNTRY INTL STAND SER NO TITLE ABBREVIATION :"o RECORD ORIGINATOR RECORD ORIGINATOR RECORD ORIGINATOR , PAGINATION JOURNAL SUBSET MESH 2 TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH SOURCE 2 UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING 86151554 Gads A Jensen HH State-dependent learning during chronic trichloroethylene exposure IletterJ Eng Animal Gerbillinae Hydrocarbons, Chlorinated/poisoning Learning/#drug effects Solvents/#poisoning Trichloroethanes/#poisoning Trichloroethylene/#poisoning 860328 1985 Dec FINLAND 0355-3140 Scand J Work Environ Health 00037 10007 R0OOO 495-7 M 21.542.808.380 6 11 UEB 71-55-6 (1,1,1-trichloroethane) 79-01-6 (Trichloroethylene) 8606 Scand J Hork Environ Health 1985 Dec>ll(6)!495-7 86135605 Blohin M Braun H Kaschny P Schill W Jastorff B Diehl K Subacute toxicity of 1,1,1-trichloroethane, noise, and their combination in rats. Eng Animal Catecholamines/metabolism Hydrocarbons, Chlorinated/*toxiclty Male Microsomes, Liver/enzymology Noise/*adverse effects Rats Rats, Inbred Strains Trichloroethanes/toxicity SL 030232 00013747 1,1,1-TRICHLOROETHANE PAGE 2 3 DATE OF ENTRY DATE OF PUBLICATION COUNTRY INTL STAND SER NO TITLE ABBREVIATION RECORD ORIGINATOR RECORD ORIGINATOR RECORD ORIGINATOR PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP ADDRESS VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT SOURCE 860409 1985 Dec UNITED STATES 0147-6513 Ecotoxicol Environ Safety 00099 10086 R0O29 295-301 M Zl.107.567.875 3 Fachbereich 1 (Physik/Elektrotechntk ) > University of Bremen> Federal Republic of Germany. 10 EDK Author 71-55-6 (1,1>l-trichloroethane) 8606 The metabolism of the xenobiotics 1p1>l-trichloroethane (TCE) or li1>2-trichloro-l>2*2-trifluoroethane and endogeneous substrates may be changed under physiological stress situations. We studied long-term effects on rats exposed to TCEp noise pollution* and their combination. The experiments were performed in a special set-up where four parallel groups of rats were simultaneously exposed to defined conditions the chemical vapor; the noise pollution of 90 dBi their combination! and a control group without any exposure. The vapor of TCE was applied at a concentration of 200 ppm/8 hr or of 2000 ppm/12 hr for 84 days each. The experiments were performed with TCE from two different commercial sources. One of those TCE preparations caused effects at the high dosage level in terms of enhanced levels of the relation of liver to body weight! liver microsomal protein content; liver microsomal monooxygenase activity! and 3(4-dihydroxyphenylglycol excretion in urine. Eight other physiological and biochemical parameters were not changed. Ecotoxicol Environ Safety 1985 'Dec!lot 31 295-301 # * * # END OF OFFLINE PRINT ***# SL 030233 o o o o o' 3 o 3 3 3 O 3 O O C* PO085545 THIS IS AN OFF-LINE BIBLIOGRAPHIC CITATION LIST GENERATED BY NEDLARS II N.L.M.'S NATIONAL INTERACTIVE RETRIEVAL SERVICE #**********##**if ###**####*#** X X*X X *#**### **X# # X #*#*# *##**#####*# * 1,1,1-TRICHLOROETHANE NUMBER OF CITATIONS PRINTED = 30 THIS SEARCH WAS PERFORMED ON THE MEDLINE SORT WAS NOT REQUESTED MAY 20, 1906 FILE. PLEASE SEND THIS LISTING TO ! DIANA DANKO / PPG INDUSTRIES,INC. P.O. BOX 31 BARBERTON, OHIO 44203 si* 03023* 4, s 00013672 /t < < i <, o o i c c o o o u 1 UNIQUE IDENTIFIER AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH SOURCE 2 UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION a` l* 11>1-TRICH LOROETHANE PAGE 1 ) 1j \s "~i ' 1 66151554 Gade A Jensen HH St ate-dependent learning during chronic trichlorcethylene exposure [letter] Eng Animal Gerbilltnae Hydrocarbons Chlorinated/#poisoning Learning/*drug effects Solvents/*poisoning Trichloroethanes/*poisoning Trichloroethylene/*poisoning 860328 1985 Dec 0355-3140 Scand J Work Environ Health 495-7 M Zl.542.808.380 6 11 UEB 71-55-6 (l>l(l-tr1chloroethane) 79-01-6 (Trichloroethylene) 8606 Scand J Work Environ Health 1985 Decillt6)J495-7 86135605 Blohm M Braun H Kaschny P Schill W Jastorff B Diehl H Subacute toxicity of ll>l-trichloroethane> noise> and their combination in rats. Eng Animal Catecholamines/metabolism Hydrocarbons > Chlorinated/*toxict ty Male Microsomes t Liver/enzymology Noise/*adverse effects Rats Rats> Inbred Strains Trichloroethanes/*toxie1ty 860409 1985 Dec 0147-6513 Ecotoxicol Environ Safety SL 030235 . 'I i J 1 1 1I 1 1 i i i J| | 1 \ j i j n i o o o 00013673 1)1,1-TRICHL0R0ETHANE PAGE 2 PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT SOURCE 3 UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING 295-301 M Zl.107.567.875 3 10 EOK Author 71-55-6 (l>ll-trichloroethane ) 8606 The metabolism of the xenobiottcs liltl-trichloroethane ITCE) or l>l2-trichloro-l >2 2-tri fluoroethane and endogeneous substrates may be changed under physiological stress situations. We studied long-term effects on rats exposed to TCE noise pollution) and their combination. The experiments were performed in a special set-up where four parallel groups of rats were simultaneously exposed to defined conditions the chemical vapor; the noise pollution of 90 dB! their combination; and a control group without any exposure. The vapor of TCE was applied at a concentration of 200 ppm/8 hr or of 2000 ppm/12 hr for 84 days each. The experiments were performed with TCE from two different commercial sources. One of those TCE preparations caused effects at the high dosage level in terms of enhanced levels of the relation of liver to body weight! liver microsomal protein content; liver microsomal monooxygenase activity! and 3>4-dihydroxyphenylglycol excretion in urine. Eight other physiological and biochemical parameters were not changed. Ecotoxicol Environ Safety 1985 Dec!10(3):295-301 86116000 Kobayashi H Hobara T Kawamoto T Sato T Sakai T CThe mechanism of respiratory arrest following 1>1>I-trichloroethane inhalation! Jpn Animal Apnea/#chemically induced/etiology Dogs Hydrocarbons> Chlorinated/*adverse effects Reflex Respiratory System/physiology Trichioroethanes/*adverse effects SL 030236 00' 74 1,1,1-TRICH LOROETHANE PAGE 3 DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE CAS REGISTRY NUMBER ENTRY MONTH SOURCE UNIQUE IDENTIFIER AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH SOURCE 860314 1985 May 0047-1879 Sangyo Igaku 170-1 M Zl.252.474.463 3 27 KK9 71-55-6 (1,1,1-trlchloroethane) 8605 Sangyo Igaku 1985 Mayi27(31:170-1 86078140 Mochida K Saito K Toxicity assessment of tetrachloroethylene, trichloroethylene and 1,1,1-trichloroethane using human and monkey cells. Eng Animal Cell Line Cercopithecus aethiops Dose-Response Relationship, Drug Human Hydrocarbons , Chlorlnated/#toxicity Lethal Dose 50 Tetrachloroethylene/#toxicity Trichloroethanes/#toxicity Trichloroethylene/*toxicity 860217 1985 Nov 0007-4861 Bull Environ Centam Toxicol 593-5 M Zl.107.567.875 5 35 BFN 127-18-4 (Tetrachloroethylene) 71-55-6 (1,1,1-trichloroethane 1 79-01-6 (Trichloroethylene1 8604 Bull Environ Contam Toxicol 1985 Novi 35(51:593-5 SL 030237 I ooo: '5 1.1.1-TRICHLOROETHANE PAGE 4 I m m n UNIQUE IDENTIFIER AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP JOURNAL TITLE CODE CAS REGISTRY NUMBER ENTRY MONTH SOURCE UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET 66057925 Pekari K Ai tio A Determination of I.1>l-trichloroethane in blood. Eng Chromatography. Gas/methods Human Hydrocarbons, Chlorinated/^blood Indicators and Reagents Trlchloroethanes/blood 860122 1985 0300-5038 IARC Sci Pubi 445-50 M 21.542.286 68 GKU 71-55-6 (1.1,1-trichloroethane) 8603 IARC Scl Publ 1985.(68)!445-50 86055254 Jarkman S Skoog KO Nilsson SE The c-wave of the electroretinogram and the standing potential of the eye as highly sensitive measures of effects of low doses of trichloroethylene. methylchloroform. and halothane. Eng Animal Dose-Response Relationship. Drug Electroretinography Eye/#drug effects Female Halothane/blood/#pharmaeodynamics Hydrocarbons. Chlorinated/*pharmacodynamics Macaca fascicularis Male Support. Non-U.S. Gov't Trichloroethanes/blood/#pharmacodynami cs Tr tchloroethylene/blood/#pharmaeodynamics 851226 1985 Oct 15 0012-4486 Doc Ophthalmol 375-82 SL 030238 M m m f 000XT13676 1.1,I-TRICHLOROETHANE PAGE S 0; 0) MESH Z TREE HUMBER Zl.542.651 ISSUE/PART/SUPP 4 VOLUME ISSUE 60 JOURNAL TITLE CODE ABSTRACT AUTHOR EBF Author 0) CAS REGISTRY NUMBER 151-67-7 (Halothane) CAS REGISTRY NUMBER 71-55-6 (1,1,1-trichloroethane) e CAS REGISTRY NUMBER ENTRY MONTH 79-01-6 (Trichloroethylene) 8603 0) ABSTRACT Lou and moderate intravenous doses of trichloroethylene niethylchloroform> and 0O' halothane dissolved in a lipid emulsion (Intralipid) were given to cynomolgus ) monkeys. The DC electroretinogram (ERG) and the standing potential of the eye (SP) were c recorded directly with corneal contact lenses> very stable calomel electrodes, and > under very constant general anesthesia. Even low doses of the substances (close to the c? hygienic threshold limit values in Sweden) clearly provoked slow variations with time In the amplitude of the c-wave of the ERG and in the SP level. Both potentials are generated mainly in the pigment epithelium. It is suggested that the effects reflect a direct influence of the chemicals upon the metabolism of the pigment epithelium or on a the cell membrane. Thus the method used is a highly sensitive measure of effects of ) certain halogenated hydrocarbons on structures belonging to the central nervous SOURCE system. Doc Ophthalmol 1985 Oct 15)60(4):375-82 $) UNiqUE IDENTIFIER 85273505 $ AUTHOR AUTHOR TITLE Ikeda M Ohtsukl T Exposure concentration versus environmental J concentration! a field survey in organic % LANGUAGE solvent workplaces. Eng J MESH HEADING Acetic Acid Esters/adverse effects MESH HEADING Air Pollutants, Occupational/#adverse effects analysis MESH HEADING Butanones/adverse effects MESH HEADING Human MESH HEADING Maximum Permissible Exposure Level MESH HEADING MESH HEADING Solvents/#adverse effects/analysis Styrenes/adverse effects ; MESH HEADING Tetrachloroethylene/adverse effects MESH HEADING Toluene/adverse effects MESH HEADING MESH HEADING Trichloroethanes/adverse effects Trichloroethylene/adverse effects 0 SL 030239 lilil-TRICHLOROETHANE PAGE 6 DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT SOURCE 8 UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR AUTHOR TITLE 650920 1965 Jun 0040-8727 Tohoku J Exp Med 225-35 M ZI.252.474.463 2 146 VTF Author 106-68-3 (Toluene) 127-18-4 (Tetrachloroethylene) 141-78-6 (ethyl acetate) 71-55-6 (Itll-trichloroethane) 76-93-3 (methylethyl ketone) 79-01-6 (Trichloroethylene) 8511 The relationship was investigated between the environmental concentrations in workplaces and the concentrations in the breath zones of the workers therein. The former was measured in 47 organic solvent workplaces of various types taking both the grid-sampling strategy (Measurement A) and a spot-air sampling to detect possible maximum exposure (Measurement B)f while the latter was determined by the application of personal samplers to 328 workers. Although a low yet significant correlation was observed between the results of Measurement A (i.e.j the combination of the geometric mean and the geometric standard deviation of the environmental concentration) and the exposure concentration! excess exposure ti.e.> over occupational exposure limit exposure) would occur in some workplaces when the occupational exposure limit itself be used as the limit value for the setting of criterion for environmental concentration. The analyses of the experiences suggest no excess exposure would be expected if half the occupational exposure limit be employed as the limit value. Tohoku J Exp Med 1985 JunU46(2>:225-35 85268724 Folbergrov'a J Hougaard K S!j 0302^0 Wssterberg E Sies) "o BK Cerebral metabolic and circulatory effects of lilil-trichloroethane* a neurotoxic industrial solvent. 2. Tissue concentrations # ( (' \ o o o o o ?! 1,1,I-TRICHLOROETHANE PAGE 7 ) o LANGUAGE MESH HEADING MESH HEADING HESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING HESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT st 30241 of labile phosphates, glycolytic metabolites, citric acid cycle intermediates, amino acids, and cyclic nucleotides, Eng Ar;;i-al Bra l n/#me t abo 1 i >m Ctrobpovmeulw' Clreulutlori/'Kdrug iffteti Citrates/metabollsm Glueose/metabolism Glycolysis Hydrocarbons , Chlor1neted/Kpharmacodynami os Lactates/metaboli sm Male Neurotox i ns/pharmacodynam i cs Nucleosides/metabolism Osmolar Concentration Phosphates/metabolism Purine Nucleotides/metabolism Pyruvates/metabolism Rats Rats, Inbred Strains Solvents/pharmacodynamics Support, Non-U.S. Gov't Trichloroet hane s/#pharmacodynamf c s 650906 1984 Spring 0734-600X Neurochem Pathol 55-68 M Zl.107.567.875 1 2 OAD Author 127-17-3 (pyruvic acid) 50-21-5 (lactic acid) 50-99-7 (Glucose) 71-55-6 (1,1,1-trichloreethane ) 77-92-9 (citric acid) 8511 In order to obtain information on the mechanisms of neurotoxicity of 1.1.1-trichioroethane, rats maintained artificially ventilated on N20:02 (70:30) were exposed to a concentration of 1.1.1-trichloroethane of 8000 ppm, 43.7 mg L-l, that induces moderate ataxia in awake, spontaneously breathing animals. After 5 and 60 min of exposure, as well as after a 60-min recovery period following 60 min of exposure, the brain was frozen in situ and cortical tissue was assayed for phosphocreatine IPCr), ') :> o j o J o '} o Z) o o '.j 000 0679 m 1,1.1-TRICHLOROETHANE PAGE 6 m m # SOURCE * ATP, ADP, AMP, glycogen, glucose, pyruvate, lactate, citric acid cycle intermediates, associated amino acids, and cyclic nucleotides? in addition, purine nucleotides, nucleosides, and bases were assayed by HPLC techniques. Exposure of animals to 1.1.1-trichloroethane failed to alter blood glucose, lactate, and pyruvate concentrations. However, the solvent induced highly significant increases in tissue lactate and pyruvate concentrations that were also reflected in cisternal CSF. Associated with these changes were increases in all citric acid cycle intermediates except succinate, an increase in alanine concentration, and a rise in the glutamate/aspartate ratio. After 5 min, a small decrease in glycogen concentration also occurred. All these changes were reversed when the exposure was terminated. No changes were observed in tissue concentrations of purine nucleotides, nucleosides, and bases except for a small reduction of ATP concentration after 60 min of exposure, still noticeable after 60 min of recovery. Apart from a small reduction in cAMP concentration after 5 min of exposure, cyclic nucleotide concentrations did not change. Neurochem Pathol 198** Spring;2ll):55-68 UNIQUE IDENTIFIER 85268723 AUTHOR Hougaard K AUTHOR Ingvar M AUTHOR Wieloch T AUTHOR Siesj "o BK TITLE Cerebral metabolic and circulatory effects of 1.1.1-trichloroethane, a neurotoxic industrial solvent. 1. Effects on local cerebral glucose consumption and blood flow during acute exposure. LANGUAGE Eng MESH HEADING Anesthes i a MESH HEADING Animal m MESH HEADING MESH HEADING Behavior, Animal/drug effects Brain/#met abolism m MESH HEADING Cerebrovascular Circulation/#drug effects MESH HEADING Electroencephalography m MESH HEADING MESH HEADING Glucose/#metabolism Hydrocarbons, Chiorinated/*pharmacodynamics MESH HEADING Male MESH HEADING Neurotoxins/pharmacodynamics MESH HEADING MESH HEADING Rats Rats, Inbred Strains <m \ i SL 030242 i i mi V OO0T36SO lilt1-TRICHLOROETHANE PAGE 9 C c r M MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT SOURCE Solvents/pharmacodynamicb Supporti Non-U.S. Gov't Time Factors Tri chi oroe thanes /#pharmacodynami cs 850906 1984 Spring 0734-600X Neurochem Pathol 39-53 M Zl.107.567.875 1 2 OAD Author 50-99-7 (Glucosel 71-55-6 (1>l>l-trichloroethaneJ 6511 The effects of inhaled 1>1>l-trichloroethane (3500. 6000. and 7800 ppm) on behavior, local cerebral blood flow, and local cerebral glucose consumption were studied in awake rats. The effect of the solvent inhalation on the EEG pattern and local cerebral blood flow was also studied in paralysed animals under N20 analgesia. Exposure of awake animals to 6000 ppm 1.1.1-trichloroethane induced a decrease in motility and exploratory behavior. At 7800 ppm the rats were clearly ataxic. The local cerebral glucose consumption in 23 brain regions was studied by the E14C]deoxyglucose technique. A decrease was observed ranging from 14 to 55Z of control values. The inferior colliculus and substantia nigra displayed the largest reductions. In exposed animals the local cerebral blood flow increased in 11 brain structures by 28-45X. In animals under N20 analgesia. 7400 ppm 1.1.1-trichloroethane induced a depression of the EEG activity. In these animals the local cerebral blood flow increased by 12-99Z, with a large variability in blood flow between the different structures. It is concluded that exposure of rats to subanesthetic doses of 1.1.1-trichloroethane induces an increase in cerebral blood flow in spite of a concomitant decrease in glucose consumption and depression of cerebral function. Neurochera Pathol 1984 Spring;2(1):39-53 SL 030243 # m # m i : i : m m M 00013581 1,1,1-TRICHLORIDE THANE PAGE 10 UNIQUE IDENTIFIER AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY OATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ENG ABSTR IND IS5UE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT 85265913 Abe T Wakui C [Necessity for total trichloride compound measurement in screening tests for workers exposed to trichloroethylene or 1>1il,-trichloroethanel Jpn Acetone/urine Air Pollutants> Occupational/#adverse effects Bu t anones/urine English Abstract Female Human Hydrocarbonsi Chlorinated/*adverse effects Male Occupational Dermatitis/diagnosis Occupational Diseases/diagnosis/#urine Solvents/*adverse effects Tetrachloroethylene/urine Toluene/urine Trichloroethanes/*adverse effects/urine Trichloroethylene/*adverse effects/urine 850906 1989 Nov 0097-1879 Sangyo Igaku 992-9 M Zl.252.979.963 A 6 26 KK9 Author 108-88-3 (Toluene) 127-18-9 (Tetrachloroethylene) 67-69-1 (Acetone) 71-55-6 (ljl!l-trichloroethane) 78- 93-3 (methylethyl ketone) 79- 01-6 (Trichloroethylene) 8511 In 9 series of physical examinations legally required for trichloroethylene (TCE) workersi levels of urinary total trichloride compounds (TTC) were revealed to be generally high in 323 specimens! including 250 male ones i collected from a medium sized company. Sixty four specimens (19.8/i)i including 56 male ones (22.9exceeded 300 mg/1 which are regarded to correspond to the threshold limit for TCE in the air of the work site. Four SL 030244 * * ts * 3 * J o o J 3 % % o o I o 00013682 SOURCE UNIRUE IDENTIFIER AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING lilil-TRICHLOROETHANE PAGE 11 J specimens had over 900 mg/1. In all 323 specimensi however, no abnormalities were found with respect to specific gravity of bloodi hemoglobin concentration and urinary tests. TTC concentration values increased in specimens in the lost 9 physical checkupsi compared with the values measured in the first 5. The cause of this increase seemed to be related to increases in the number of products and the hours of overtime work. Symptoms felt by these workers gradually subsided as they were continuously exposed to TCE for more than 2 or 3 years. Some workers of long service had a tendency toward addiction to TCE. In the legally required environmental monitoring of TCEi and other harmful organic solvents! the 8 workplaces fell into either classification 1 or 2i indicating that the environmental conditions are not harmful. More importantly! the above evaluations did not take into account long hours of overtime put In by those workers. Turning to the checkups of lilil-trichloroethane workers! the results of legally required physical checkups and environmental monitoring were almost the same as those for TCE.(ABSTRACT TRUNCATED AT 250 WORDS) Sangyo Igaku 1989 Nov!26(6):992-9 85298900 Isacson P Bean JA Splinter R Olson DB Kohler J Drinking water and cancer incidence in Iowa. III. Association of cancer with indices of contamination. Eng Adolescence Adult Aged Bladder Neoplasms/occurrence Carcinogens, Environmental/*analysis Child Child Preschool Chlorine Colonic Neoplasms/occurrence Ethylene Dichlorides/analys i s Female Human Infant SL 030245 CJ 3 3 3 3 3 3 01 | <3 \ O! o; vi m: i* I I# I i # & * 00013683 1,1,1-TRICHLOROETHANE PAGE 12 MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING ID NUMBER DATE OF ENTRY DATE OF PUBLICATION INTL STAND SFR NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET JOURNAL SUBSET MESH Z THEE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT Iowa Lung Neoplasms/occurrence Male Middle Age Neoplasms/chemically induced/*occurrence Nickel/analysis Rectal Neoplasms/occurrence Risk Socioeconomic Factors Support, U.S. Gov't( Non-P.H.S. Support, U.S. Gov'tf P.H.S. Tetrachloroethylene/analysis Trichloroethanes/analysis Trichloroethylene/analysis Water Pollutants/*adverse effects Water Pollutants> Chemical/#adverse effects N01CP43200 650816 1985 Jun 0002-9262 Am J Epidemiol 856-69 M X Zl.107.567.875 6 121 3H3 Author 107-06-2 (ethylene dichloride) 127-18-A (Tetrachloroethylene) 71-55-6 (1,1,1-trichioroethane) 79AO-02-0 (Nickel) 7782-50-5 (Chlorine) 79-01-6 (Trichloroethylene) 8510 With data from the Iowa Cancer Registry, age-adjusted sex-specific cancer incidence rates for the years 1969-1981 were determined for towns with a population of 1,000-10,000 and a public water supply from a single stable ground source. These rates were related to levels of volatile organic compounds and metals found in the finished drinking water of these towns in the spring of 1979. Results showed association between 1,2 dichloroethane and cancers of the colon and rectum and between nickel and cancers of the bladder and lung. The effects were most clearly seen in males. These associations were independent of other water quality and treatment variables and were not explained by occupational or other sociodemographic SL 030246 00^^84 1,1,1-TRICH LOROETHANE PAGE 13 C# ,_3 o <3 (3 (3 e w -- SOURCE 12 UNiqUE IDENTIFIER AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH \I features including smoking. Because of the low levels of the metals and organics* the authors suggest that they are not causal factors* but rather indicators of possible anthropogenic contamination of other types. The data suggest that water quality variables other than chlorination and trihalomethanes deserve further consideration as to their role in the development of human cancer. Am J Epidemiol 1985 Jun*121(6)5856-69 65219671 Kjellstrand P Holmquist B Jonsson I Romare S M'ansson L Effects of organic solvents on motor activity in mice. Eng Administration* Intranasal Animal Behavior* Animal/drug effects Binding Sites Biotransformat ion Dose-Response Relationship* Drug Male Methylene Chloride/pharmacodynaraics Mi ce Motor Activity/drug effects Solvents/pharmacodynamics Support* Non-U.S. Gov't Tetrachloroethylene/pharmacodynamics Time Factors Toluene/pharmacodynamics Trichloroethanes/pharmacodynamics 650627 1965 Apr 0300-483X Toxicology 35-46 M X Zl. 542.651 1 35 VWR Author 106-88-3 (Toluene) 127-18-4 (Tetrachloroethylene) 71-55-6 (l*l,l-trichloroethane) 75-09-2 (Methylene Chloride) 6509 SL 30247 c$ (i < m o* a# 000X3685 1,1,1-TRICHLOROETHANE PAGE & ABSTRACT a # SOURCE 13 UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING m MESH HEADING MESH HEADING Groups of male mice were exposed via Inhalation to methylene chloride> perchloroethylene, toluene, triehioroethylene or 1>1.1-trichloroethane. The exposures were started at 300 h. Generation of vapor was stopped after 1 h. Motor activity of the animals during the exposures was measured with a Doppler radar. Several concentrations of each solvent were tested. Concentrations could be found for all solvents at which they initially increased the motor activity. When the generation of vapor was terminated and the concentration started to decline, a new phase of changes in motor activity was induced. At this phase, motor activity was in most cases influence in the opposite direction to that at the beginning of the exposure. Trichloroethylene concentrations could be found which gave no increase in activity at the start of exposure but a prominent decrease at termination. The lowest concentration at which effects could be seen was different for the different solvents. Perchloroethylene was more and 1.1tl-trichloroethane less potent than the other solvents in inducing motor activity. The time pattern of the motor activity alterations was specific for each solvent. Both the concentration and the rate of the concentration increase were responsible for the effects on motor activity. The differences between the solvents probably reflect differences in their site of action, their distribution and their biotransformation. Toxicology 19B5 AprS35(1):35-46 85188951 Moser VC Scimeca JA Balster RL Minimal tolerance to the effects of 1.1.1-trichloroethane on fixed-ratio responding in mice. Eng Air Pollutants/toxicity Animal Conditioning. Operant/*drug effects Drug Tolerance Hydrocarbons > Chlorinated/#toxicity Male Mi ce Support, U.S. Gov't, P.H.S. SL 030248 '3 3 &. o o a & o o 0 o 0 V 000X3686 1,1,1-TRICHLOROETHANE PAGE 15 MESH HEADING MESH HEADING ID NUMBER ID NUMBER DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT SOURCE Time Factors Trichloroethanes/#toxicity DA-00490 ES-07087 850618 1985 Spring 0161-613X Neurotoxicology (Little Rock Ar) 35-42 M Zl.107.567.875 1 6 OAP Author 71-55-6 (1,1,1-trichloroethane) 8508 Most laboratory animal studies of the behavioral or neurophysiological effects of repeated exposures to volatile organic solvents find little evidence for substantial tolerance. This study examined the development of tolerance to the effects of 1,1,1-trichloroethane (1 jl >1-TCE ) on fixed-ratio responding in four mice. The subjects were exposed to 6000 ppm solvent vapor for 20 min of the daily 45-min operant sessions. Once a week, a series of four concentrations (1000-8000 ppm) were substituted for the daily exposure in order to obtain a cumulative concentration-effect curve. This proved to be a rapid and reliable method with which to ascertain the effects of lill-TCE over a range of concentrations. During the 15 days of 20-min exposure, the subjects showed a slight but significant increase in both response rates during exposure and in the rate of recovery following exposure. Maximal changes in these measures were evident in the first 7 days with no further decreased sensitivity over the final 8 days of exposure. The concentration-effect curves determined during and after the daily exposures showed no significant shifts in either direction from the initial curve. Thus, while some alteration in the daily acute effects was noted, this tolerance was not of large magnitude and could not be detected as a change in the concentration-effect curve. Neurotoxicology (Little Rock Ar) 1985 Spring,6(1)t35-42 SL 030249 00013667 1.1.1-TRICHLOROETHANE PAGE 16 & UNIQUE IDENTIFIER 85183837 AUTHOR Mitchell D AUTHOR Ibrahim S u AUTHOR TITLE Gusterson BA I- rt oved immunohlstochemical localization of tissue antigens using modified ntethacarn fixation. a LANGUAGE MESH HEADING Eng Acetic Acids/diagnostic use MESH HEADING Act ins/immunology MESH HEADING a MESH HEADING MESH HEADING Alcohol. Ethyl/diagnostic use Alcohol. Methyl/diagnostic use Breast/#immunology MESH HEADING Breast Neoplasms/*immunology MESH HEADING Chloroform/diagnostic use a MESH HEADING MESH HEADING Col1agen/immuno1ogy Comparative Study MESH HEADING Epithelium/immunology MESH HEADING Factor VUI/immunology a MESH HEADING MESH HEADING Female Fixatives MESH HEADING Fluorescent Antibody Technic MESH HEADING Histocytochemistry/methods MESH HEADING Human MESH HEADING Isoantigens/*analysIs MESH HEADING Trichloroethanes/diagnostic use DATE OF ENTRY 850528 DATE OF PUBLICATION 1935 May INTL STAND SER NO 0022-1554 TITLE ABBREVIATION J Histochem Cytochem PAGINATION 491-5 JOURNAL SUBSET M JOURNAL SUBSET X MESH Z TREE NUMBER Zl.107.567.875 ISSUE/PART/SUPP 5 a VOLUME ISSUE JOURNAL TITLE CODE 33 IDZ ABSTRACT AUTHOR Author CAS REGISTRY NUMBER 0 (Carnoy's solution) Q CAS REGISTRY NUMBER CAS REGISTRY NUMBER 64-17-5 (Alcohol. Ethyl) 67-56-1 (Alcohol, Methyl) CAS REGISTRY NUMBER 67-66-3 (Chloroform) CAS REGISTRY NUMBER 71-55-6 (1,1,1-trichloroethane) CAS REGISTRY NUMBER 9007-34-5 (Collagen) ENTRY MONTH 8508 ABSTRACT Detailed comparative studies have been carried out using a wide range of aqueous and nonaqueous based fixatives in order to select the optimal fixation schedule for the m immunohistochemical localization of four antigens: type IV collagen, actin, Factor VIII, and epithelial membrane antigen (EMA). SL 030250 wm OoH?688 i> 1,1,1-TRICHLOROETHANE PAGE 17 U U o o u o SOURCE Modified methacarn fixation provides an ideal combination of maximum staining and morphological preservation for these antigens. Enhanced immunoreaetlvity with this fixative was also noted for a broad spectrum of antigens, including myoglobin* glial fiber acidic protein* keratin, myosin, laminin, prostatic acid phosphatase, alpha-fetoprotein, and earcinoembryonic antigen. Although it is not recommended for most cell surface antigens, this fixative may have a definite place in diagnostic surgical pathology. J Histochem Cytochem 1985 May!33<5):491-5 (J o o o o 15 UNIQUE IDENTIFIER AUTHOR 65180305 Takano T c* AUTHOR Miyazaki Y AUTHOR Motohashi Y o TITLE Interaction of trichloroethane isomers with cytochrome P-450 in the perfused rat liver. c* LANGUAGE Eng MESH HEADING Animal o MESH HEADING MESH HEADING Cytochrome P-450/*metabolism Hemoglobins/metabolism % MESH HEADING Hexobarbital/metabol i sm MESH HEADING Hydrocarbons > Chlorinated/#toxidty o MESH HEADING MESH HEADING In Vitro Is outer i sm MESH HEADING Li ver/*enzymology MESH HEADING Male o MESH HEADING MESH HEADING NAD/metabolism NADP/metaboli sm MESH HEADING Oxygen Consumption/drug effects MESH HEADING Rats MESH HEADING u MESH HEADING Rats, Inbred Strains Spectrometry, Fluorescence MESH HEADING Spectrophotometry MESH HEADING Trichloroethanes/metabolism/#toxicity o DATE OF ENTRY DATE OF PUBLICATION 850606 1985 Apr <* INTL STAND SER NO 0272-0590 TITLE ABBREVIATION Fundam AppI Toxicol a PAGINATION JOURNAL SUBSET 353-60 M MESH Z TREE NUMBER 21.107.567.875 ISSUE/PART/SUPP 2 # VOLUME ISSUE JOURNAL TITLE CODE 5 FAB a ABSTRACT AUTHOR Author CAS REGISTRY NUMBER 53-59-8 CNADP) CAS REGISTRY NUMBER CAS REGISTRY NUMBER 53-84-9 (NAD) 56-29-1 (Hexobarbital) SL 030251 a a ooorSrao 1,1,1-TRICHLOROETHANE PAGE IS CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT W O Q V Q O SOURCE 16 UNIQUE IDENTIFIER AUTHOR AUTHOR TITLE <J Q J! LANGUAGE MESH HEADING MESH HEADING 71-55-6 11>1,1-trichloroethane) 79-00-5 (1,1>2-trichloroethane) 9035-51-2 {Cytochrome P-950 ) 8508 The real-time interactions of 1.1.1-trichloroethane (TCE) and 1,1,2-TCE with cytochrome P-950 were observed using in vivo optical methods to measure the spectral changes of cytochrome P-950 and the reduction-oxidation transition of pyridine nucleotides in the perfused liver of rats treated with phenobarbital. Changes in oxygen consumption and TCE uptake were also measured. The spectral changes of cytochrome P-950 indicated that both TCE isomers bound to low spin (substrate free) ferric cytochrome P-950 and formed a high spin (substrate complexed) form. `However, 1.1.1-TCE bound more tightly to cytochrome P-950 and seemed to be only slowly metabolised compared to 1,1,2-TCE. The stoichiometry of the change in oxygen consumption rate to the change in 1,1,1-TCE uptake rate ranged between 5/1 and 9/1, whereas that of 1,1,2-TCE was 1.9 to 2.0. Decreases in reduced pyridine nucleotides associated with TCE administration were significantly larger with 1,1,1-TCE than with 1.1.2-TCE. The inhibitory effect of 1,1,1-TCE on hexobarbital metabolism in the perfused liver was greater than that of 1,1,2-TCE. Considering our previous data indicating that TCE did not stimulate mitochondrial respiration, it is postulated that the far higher amount of oxygen consumption associated with the binding of 1,1,1-TCE to cytochrome P-950 than the amount which wa3 necessary to mixed-function oxidation of this compound was due to an uncoupling effect of 1,1,1-TCE on the mixed-function oxidase system. Fundam Appl Toxicol 1985 Apr;5i2):353-60 65193057 Moser VC Bolster RL Acute motor and lethal effects of inhaled toluene, 1,1,1-trichloroethane, haiothane, and ethanol in mice: effects of exposure duration. Eng Alcohol, Ethyl/toxicity Animal SL 030252 m m m m % m < in mi m % o o u o io u !O | :a i M 00^^90 1,1,1-TRICHLOROETHANE PAGE 19 MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING ID NUMBER ID NUMBER DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP Volume issue JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT Atmosphere Exposure Chambers Dose-Resporse Relationship, Drug Halothane/fctoxicity Lethal Dose 50 Male Mi ce Motor Activity/*drug effects Solvents/#toxicity Support, U.S. Gov'ti P.H.S. Time Factors Toluene/toxici ty Trichloroethanes/toxicity DA00490 ES-07087 8503E5 1985 Feb 0091-006X Toxicol Appl Pharmacol 285-91 M X Zl.107.567.875 77 vuo Author 108-88-3 (Toluene) 151-67-7 (Halothane) 69-17-5 (Alcohol, Ethyl) 71-55-6 (1,1,1-trichloroethane) 6506 Some acute effects of inhalation exposure to toluene, 1,1,1-trichloroethane (1>1>1-TCE ), halothane, and ethanol were examined in mice. Lethality and performance on an inverted screen test of motor performance were measured following 10-> 30-> and 60-min exposures. Concentration-dependent effects were obtained on both measures for all solvents except that lethal concentrations of ethanol could not be produced under these exposure conditions. Lethality increased with longer exposures for toluene> 1,1,1-TCE, and halothane. Sensitivity to the motor effects of 1,1,1-TCE, halothane* and ethanol increased when exposure duration was increased from 10 to 30 mint with no further change with 60-min exposures. In contrastt behavioral sensitivity to toluene increased over the entire range of exposure durations. The relative lipid solubilities of the solvents correlate with potency for behavioral activity but not as well with 030253 SL 000X3691 1,1,1-TRICH L0R0ETHANE PAGE 20 SOURCE 17 UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET JOURNAL SUBSET JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT potency for lethality. The ratio of potency for motor and lethal effects depended on the chemical studied and in some cases exposure duration. These results demonstrate that both concentration and exposure duration determine the effects of inhaled compounds! but a simple linear relationship does not exist and it depends upon the effect measured, Toxicol Appl Pharmacol 1985 FebJ77(2)!285-91 85135189 King GS Smialek JE Troutman HG Sudden death in adolescents resulting from the inhalation of typewriter correction fluid. Eng Adolescence Arrhythmia/chemically induced Case Report Death> Sudden/#etiology Female Human Male Solvents/*poisoning Substance Abuse/*coraplications Trichloroethanes/poisoning Trichloroethylene/poisoning 650329 1965 Mar 15 0093-7989 JAMA 1609-6 A M X Zl.107.567.875 11 253 KFR Author 71-55-6 (1,1,1-trichloroethanel 79-01-6 (Trichloroethylene) 8506 Inhalation abuse of various toxic agents continues to be a significant health problem among the younger segment of our society. We describe four cases of sudden death in adolescents associated with recreational sniffing of typewriter correction fluid occurring during the period 1979 through mid-1989. The solvents used in most of these fluidsi 1 ili1-trichloroethane and SL 030254 ! vJ i | 1a | <{ Cl o a i, a a a a 00013692 1,1,1-TRICHLOROETHANE PAGE 21 SOURCE 8 UNIQUE IDENTIFIER AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION MESH Z TREE NUMBER ' ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE CAS REGISTRY NUMBER ENTRY MONTH SOURCE 9 UNIQUE IDENTIFIER AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION trichloroethylene, are known to induce potentially fatal arrhythmias. Sniffing typewriter correction fluid poses a significant and underappreciated danger to the lives of these abusers. School health officials, public health departments, and law enforcement personnel should be alerted to the need for surveillance of this type of activity. JAMA 1985 Mar 15iZ53(11):1604-6 85079429 Wright MF Strobl DJ 1.1.1- Trichloroethane cardiac toxicity: report of a case. Eng Arrhythmia/#chemically induced Case Report Chemistry Human Hydrocarbons, Chlorinated/*adverse effects Male Middle Age Occupational Diseases/#chemically induced Trichloroethanes/*adverse effects 850205 1984 Nov 0003-0287 J Am Osteopath Assoc 285-8 Zl.107.567.875 3 84 G90 71-55-6 (1,1,1-trichloroethane) 8504 J Am Osteopath Assoc 1984 NovJ84(3)=285-8 65061648 Mack RB Cyrano De Bergerac would have loved 1.1.1- trichloroethane. Eng Euphoria/drug effects Human ^Hydrocarbons, Chlorinated Substance Use Disorders/etiology #Trichloroethanes 841226 1984 Oct 0029-2559 SL 030255 NC Med J 00013693 1,1f1-TRICH LOROHTHANE PAGE 22 PAGINATION MESH 2 TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE CAS REGISTRY NUMBER ENTRY MONTH SOURCE 0 UNIQUE IDENTIFIER AUTHOR o AUTHOR AUTHOR AUTHOR TITLE o LANGUAGE MESH HEADING MESH HEADING o MESH HEADING MESH HEADING MESH HEADING MESH HEADING o MESH HEADING MESH HEADING MESH HEADING o DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION o PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ENG ABSTR IND o ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT (\ I IT 661-2 Zl.107.567.875 10 45 NTX 71-55-6 (lilfl-trichloroethane) 8503 NC Med J 1984 Oct;45<10):661-2 85058812 Kobayashi H Hobara T Kawamoto T Sakai T [Peripheral vasodilator effect of 1tl>l-trichloroethane inhalation! Jpn Administration, Intranasal Animal Blood Pressure/drug effects Dogs English Abstract Hindiimb/blood supply Hydrocarbons , Chiorinated/xpharmacodynemics Trichloroethanes/administration A dosage ^pharmacodynamics Vasodilation/*drug effects 650122 1984 Mar 0047-1879 Sangyo Igaku 112-5 M Zl.252.474.463 A 2 26 KK9 Author 71-55-6 (1(1,1-trichloroethane) 8503 It is presumed that systemic hypotension resulting from high concentration of lil.1-trichloroethane 11(1>1-TCE) inhalation may be induced by functional depression of the central nervous system. However> it is still uncertain the possibilities that one of the site of action where 1,1,1-TCE acts in systemic hypotension existed in the portion without the central nervous system. The present experiment was performed to investigate the role of the peripheral vessels as a site of action in the systemic SL 030256 * & m $ & a o o -j 1* I :a o # a # m # * 4# ill 00013694 1>1il-TRICHLOROETHANE PAGE 23 SOURCE UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO hypotension following 1(11-TCE inhalation. The right hindlimb of a dog anesthetized with sodium pentobarbital (25-30 mg/kg( intravenously) was amputated at the central level of the thigh bone leaving muscles and nerves. The isolated hindlimb was perfused with blood at a constant flow rate using a pump. Venous blood circulated in the isolated hindlimb was returned to the femoral vein. To measure the perfusion pressure of the isolated hindlimb> a small catheter wa3 inserted into the artery and was connected to a pressure transducer (Nihon Kohdeni MPU-0.5). In this perfusion experiment! the changes in perfusion pressure following lilil-TCE inhalation are shown to be the reaction of peripheral vessels only as the site of action of lilil-TCE. In other wordsi the effects of ltlfl-TCE on central nervous system could be completely removed. Various concentrations of lill-TCE vapor> made by an inside circuit vaporizeri were inhaled during a period of approximately 2 min. Perfusion pressure was continuously recorded beforei during and after the termination of inhalation.(ABSTRACT TRUNCATED AT 250 WORDS) Sangyo Igaku 1984 Mar!26(2)J112-5 85045628 Kobayashi H Hobara T Kawamoto T Sakai T Peripheral vasodilatation following lilil-trichloroethane inhalation! peripheral vessels as a site of action. Eng Animal Blood Pressure/drug effects Dogs Hindlimb/*blood supply Human Hydrocarbonsi Chlorinated/*pharmacodynamic3 Hypotension/chemically induced Male Perfusion Trichloroethanes/pharmacodynamics Vascular Resistance/drug effects Vasodilation/drug effects Vasodilator Agents/#pharmacodynamics 841126 1984 Jul-Aug 0003-9896 SL 030257 m m * m m m & m m m m m m o J ' t o- o. o o i\ \ 00013695 1,1,1-TRICHLOROETHANE PAGE 24 TITLE ABBREVIATION PAGINATION JOURNAL SUBSET JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT SOURCE 22 UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING Arch Environ Health 294-8 A M Zl.107.567.875 4 39 6YO Author 71-55-6 11,1,1-trichloroethane) 8502 The effects of 1>1il-trichloroethane (lilil-TCE) inhalation on total peripheral vascular resistance and the possibility of the peripheral vessels being a site of action for lilil-TCE were investigated in anesthetized dogs. In acute inhalation experimentst a decrease in total peripheral vascular resistance was observed following inhalation of 1(1,1-TCE concentrations sufficient to induce systemic hypotension. The threshold concentration of 1>1>1-TCE required to produce a decrease in perfusion pressure of the isolated hindlimb was approximately 0.4-0.5Z In inspired air. A dose-response relationship between the decrease in perfusion pressure and lilil-TCE concentration! which exceeded the threshold leveli was observed. It is suggested that the decrease in total peripheral vascular resistance is related to systemic hypotension following ltlil-TCE inhalation} further this vasodilator effect may be induced in the peripheral vessels i which is one of the sites where lilil-TCE acts. Arch Environ Health 1984 Jul-Aug>39(4)5294-8 85021576 Hobara T Kobayashi H Higashihara E Kawamoto T Sakai T Acute effects of lil>l-trichloroethanet trichloroethylene! and toluene on the hematologic parameters in dogs. Eng Animal Blood Cell Count Blood Cells/#drug effects Dogs Female Hydrocarbons t Chlorinated/toxi ci ty S 30?,,, lv ' 0- 00013696 1,I,1-TRICHLOROETHANE m PAGE 25 0 m # mim m w 4k w w 4wk 4k w w aW M MESH heading MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH SOURCE 23 UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER ENTRY MONTH Male Toluene/*toxici ty Trichloroethanas/toxi eity Trichloroethylena/*toxici ty 84T-.U9 198A Sap 0090-4341 Arch Environ Contam Toxicol 589-93 Zl.107.567.875 5 13 6YO 108-88-3 tToluene) 71-55-6 tldd-trichloroethane) 79-01-6 (Trichloroethylene) 8501 Arch Environ Contam Toxicol 1984 Sep >13(5)i569-93 65004524 Nolan RJ Freehour NL Rick DL McCarty LP Saunders JH Kinetics and metabolism of Inhaled methyl chloroform (llil-trichloroethane) in male volunteers. Eng Adult Bi o trans format i on Exertion Human Hydrocarbons > Chlor inated/*inetaboli sm Kinetics Male Middle Age Time Factors Tri chloroethanes/*metabol ism 841105 1984 Aug 0272-0590 Fundam Appl Toxicol 654-62 M Zl.107.567.875 4 4 FAB Author 71-55-6 (1(1 d-trichloroethane) 8501 SL 030259 |j| V ^ w ^jj| ini' M * 00013697 Q 1,1*1-TRICHLOROETHANE PAGE 6 ABSTRACT O o o o \ SOURCE 4 UNIQUE IDENTIFIER r 'i AUTHOR AUTHOR TITLE r'"' LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY The kinetics of inhaled! methyl chloroform (MC) and its principal metabolites* trichloroethanol (TCE> and trichloroacet1c acid (TCA), were defined in six healthy male volunteers following single 6-hr exposures of 350 and 35 ppm. Blood and expired air MC concentrations were proportional to the exposure concentration and indicated that about25X of the MC inhaled during the 6-hr exposure was absorbed. Elimination of MC was triexponential with half-lives estimated as 44 min* 5.7 hr, and 53 hr for the initial, intermediate, and terminal phases. Over 91X of the absorbed MC was excreted unchanged via the lungs, 5-6X was metabolised and excreted as TCE and TCA, and less than IX remained in the body after 9 day3. Urinary TCE and TCA excretion was extremely variable and indicated that urinary TCE and TCA measurements provide at best only a rough estimate of the exposure. These data suggest that the kinetics of MC in man are essentially first order at or below the current TLV of 350 ppm. Based on a comparison of the blood MC levels and amounts of MC metabolized, the rat is a better model than the mouse to predict the toxicity of MC in man. Fundam Appl Toxicol 19B4 Aug!4t4)1654-62 84E05943 Casciola LA Ivanetich KM Metabolism of chioroethanes by rat liver nuclear cytochrome P-450.' Eng Animal Bio transformation Cell Fractionation Cell Nueleus/*metabolIsm Cytochrome P-450/#metabolism thane/#analogs t derivatives/metabolfsm Ethylene Dichlorides/#metabolism Hydrocarbons, Chlorinated/#metabolism Kinetics Liver/drug effects/*metabolism Male Microsomes, Liver/metabolism Phenobarbital/pharmacodynamics Rats Support, Non-U.S. Gov't Trichloroethanes/#metabolism 840625 SL 030260 I 00013698 1,1,1-TRICH LOROETHANE PAGE 27 DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/5UPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT 1984 May 0143-3334 Carcinogenesis 543-8 M X Zl.107.567.875 5 5 C9T Author 107-06-2 (ethylene dtchloride) 50-06-6 (Phenobarbital) 71-55-6 (1,1,1-triehloroethane) 74-84-0 (Ethane) 79-34-5 li1>2,2-tetrachloroethane) 9035-51-2 (Cytochrome P-450) 8409 li2-Dichloroethane, 1,1,1-trichloroethane and 1>1>2,2-tetrachloroethane appear to be metabolised by hepatic nuclear cytochrome P-450. All of these compounds are converted to chlorinated metabolites after incubation with hepatic nuclei and an NADPH-generating system plus EDTA, with the omission of any component eliminating metabolite production. In addition, CO, an inhibitor of cytochrome P-450, diminished the production of the chlorinated metabolites by hepatic nuclear preparations. The major metabolites of the chlorinated ethanes from hepatic microsomal cytochrome P-450, vis. chloroacetaldehyde from 1,2-dichloroethane, 2,2,2-trichloroethanol from 1.1.1- trichloroethane, and dichloroacet1c acid from 1,1,2,2-tetrachloroethane, were also produced from the three chloroalkanes by hepatic nuclear cytochrome P-450. The levels of the metabolites produced were 65, 0.09 and 4.4 nmol/nmol cytochrome P-450/60 min. It is proposed that the pathways for the formation of these metabolites by hepatic nuclear cytochrome P-450 are as for their production by hepatic microsomal cytochrome P-450. Chloral hydrate was produced from 1.1.1- trichloroethane by hepatic nuclei plus NADPH, but not by hepatic microsomes. The presence of reactive species or transient ensyrae bound intermediates in the pathways for the cytochrome P-450 dependent metabolism of the chloroethanes in hepatic nuclei is suggested by the observation that nuclear cytochrome P-450 is degraded in the presence SL 030?fil 00013699 0 1,1,1-TRICHLOROETHANE PAGE 28 o o o SOURCE of the chloroethanes In a NADPH dependent process which is inhibited by CO. It is proposed that* although the cytochrome P-450 dependent metabolism of the chloroethanes in microsomes can greatly exceed that in nuclei* the metabolism of 1*2-dichloroethane and 1,1*2>2-tetrachloroethane by nuclear cytochrome P-450 may in part mediate the mutagenicity and carcinogenicity of parent compounds. Carcinogenesis 1984 May!5(5):543-8 o UNIQUE IDENTIFIER 84173151 AUTHOR Koizumi A AUTHOR Fujita H AUTHOR Sadamoto T AUTHOR Yamamoto M AUTHOR Kumai M AUTHOR Ikeda M TITLE Inhibition of delta-aminolevulinic acid dehydratase by trichloroethylene. LANGUAGE Eng MESH HEADING Aminolevulinic Acid Dehydratase/*antagonists t inhibitors MESH HEADING Aminolevulinic Acid Synthetase/metabolism MESH HEADING Animal MESH HEADING Bone Harrow/enzymology MESH HEADING Erythrocytes/ensymology 'Vt# MESH HEADING Ethylene Chiorohydr in/analogs A derivatives pharmacodynamics MESH HEADING In Vitro MESH HEADING Liver/ensymology MESH HEADING Male MESH HEADING Phenobarbital/pharmacodynamics MESH HEADING Rats MESH HEADING Rats, Inbred Strains MESH HEADING Trichloroacetic Acid/pharmacodynamics MESH HEADING Trichloroethanes/pharmacodynamics MESH HEADING Trichloroe thy1ene/*pharmacodynamics DATE OF ENTRY 840511 DATE OF PUBLICATION 1984 Mar INTL STAND SER NO 0300-483X TITLE ABBREVIATION Toxicology PAGINATION 93-102 JOURNAL SUBSET M JOURNAL SUBSET X MESH 2 TREE NUMBER 21.542.651 ISSUE/PART/SUPP 2 VOLUME ISSUE 30 JOURNAL TITLE CODE VWR ABSTRACT AUTHOR Author CAS REGISTRY NUMBER EC 2.3.1.37 (Aminolevulinic Acid Synthetase) CAS REGISTRY NUMBER EC 4.2.1.24 (Aminolevulinic Acid Dehydratase) SL 030262 00013700 1,1,1-TRICHLOROETHANE PAGE 29 CAS REGISTRY NUMBER 107-07-3 (Et*-'dene Chlorohydrin) CAS REGISTRY NUMBER 115-20-8 t 2,2,2-trichloroethanol) CAS REGISTRY NUMBER 50-06-6 (Phenobarbetal) CAS REGISTRY NUMBER 71-55-6 11,1,1-trichloroethane) CAS REGISTRY NUMBER 76-03-9 (Trichloroacetic Acid) CAS REGISTRY NUMBER 79-01-6 (Trichloroethylene> ENTRY MONTH 8407 ABSTRACT Male Mi star rats (8 antroals/group; 180-200 g) were exposed continuously to trichloroethylene (TRI) for 48 or 240 h or methylehloroform (1,1, 1-trichloroethane: MC for 48 h at 50, 400 and 800 ppm. The inhibition of delta-aminolevulinic acid dehydratase (AlA-D) was examined in liver, blood and bone marrow of naive and phenobarbital pretreated animals exposed to TRI. A clear cut dose-effect relationship between the exposure concentration or duration of exposure and the inhibition of 1 ALA-D activity was seen for rats exposed to TRI. In addition to this finding, significant interaction between TRI exposure and phenobarbital treatment was observed In the inhibition of ALA-D in liver and blood. MC did not produce inhibition. Trichloroacetic acid and trichloroethanol failed to inhibit the ALA-D activity in vitro. It seems that a metabolite(s) of TRI other than the above 2 substances may play a role in the inhibition of ALA-D. The inhibition of ALA-D (38/! or 48/! i of the control in liver or in blood, respectively) observed after the 240 h exposure at 400 ppm to TRI was accompanied by the significant elevation of delta-aminolevulinic acid synthase (186X of the control) in liver and the increase in excretion of delta-aminolevulinic acid fn urine (142/! of the control). This occurred without an apparent weight loss, liver injury or hematological changes. SOURCE Toxicology 1984 Mar,30(2):93-102 26 UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING si 030263 84150493 Otson R Ui 11iams DT Bothwell PD Fabric protectors. Part II - Propane, 1,1,1-triehloroethane, and petroleum distillates levels in air after application of fabric protectors. Eng Air Pollutants, Environmental/#analysis Environmental Exposure 00013701 o 1,1,1-TRICHLOROETHANE PAGE 30 o o o o MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/5UPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT SOURCE 27 UNIQUE IDENTIFIER AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADIMG MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO ^Household Products Human Hydrocarbons, Chlorinated/*analysi3 Petroleum/*analysis Propane/#analys 1 s Time Factors Trichloroethanes/*analys1s 840425 1984 Jan 0002-8894 Am Ind Hyg Assoc J 28-33 M Zl.107.567.875 1 45 3CI Author 71-55-6 (1,1,1-trichloroethane) 74-98-6 (Propane) 8406 Propane, 1,1,1-trichloroethane, and petroleum distillates levels in air which were generated during the use of aerosol type fabric protectors were monitored by means of the NIOSH charcoal tube, a glass bulb grab sampling, and the GASBADGE passive device techniques. Although 1982 ACGIH TLV-STEL were readily exceeded in an unventilated test room, when fabric was sprayed with 450 g of fabric protector in an unconfined area within a home the generated vapors quickly dispersed and STEL and 8-hour TWA-TLV were not exceeded Am Ind Hyg Assoc J 1984 Jan;45(l)=28-33 84150492 Otson R Hi 11iams DT Fabric protectors. Part I - Evaluation of a grab sampling technique for determination of organic vapors. Eng Air Pollutants, Environmental/#analysis ^Household Products Hydrocarbons, Chiorina ted/#analysis Methods Petroleum/#analys i s Propane/*analysi s Trichloroethanes/#analysi s Volatilizat i on 840425 1984 Jan . 0002-8894 g-L 030264 00013702 1f1,1-TRICHLOROETHANE PAGE 31 TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH 2 TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT SOURCE 28 UNIQUE IDENTIFIER AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET JOURNAL SUBSET MESH 2 TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER Am Ind Hyg Assoc J 24-7 M 21.107.567.875 1 45 3CI Author 71-55-6 (1,1,1-trlchloroethane) 74-98-6 (Propane) 8486 A grab sampling technique utilizing evacuated glass sampling bulbs uias evaluated and was found suitable for the simultaneous determination of propane> 1i1i1-trichloroethanei and petroleum distillates which would be generated Into air during the use of fabric protectors. Am Ind Hyg Assoc J 1984 Jan)45(1):24-7 84121320 Maugh TH 2d What is the risk from chlorofluorocarbons? Eng #Air Pollutants> Environmental ^Atmosphere Carbon Tetrachloride Chemistry Free Radicals #Freons Nitrogen Dioxide Nitrous Oxide Oxygen #Ozone Photochemistry Risk Tr ichloroethanes Ultraviolet Rays 840321 1984 Mar 9 0036-8075 Science 1051-2 M X 21.107.567.875 4640 223 UJ7 10024-97-2 (Nitrous Oxide) 10028-15-6 (Ozone) 10102-44-0 (Nitrogen Dioxide) 17778-80-2 (singlet oxygen) SL 030265 00013703 9 ldd-TRICHLOROETHANE PAGE 32 CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH SOURCE UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT 56-23-5 [Carbon Tetrachloride) 71-55-6 (1>1>1-trichloroethane > 7782-44-7 (Oxygen) 8405 Science 1984 Mar 9J223(4640)U051-2 84108270 Nestmann ER Otson R Koubel DJ Bofhue11 PD Harrington TR Mutagenicity in a modified Salmonella assay of fabric-protecting products containing 1 dd-trichloroethane. Eng Aerosols Household Products Hydrocarbons > Chlorinated/*toxicity Mutagenicity Tests *Mutagens Salmonella/drug effects Trichloroethanes/fctoxicity 840319 1984 0192-2521 Environ Mutagen 71-80 M X Zl.107.567.875 1 6 EIY Author 71-55-6 (ltid-tri chloroethane ) 8405 Methyl chloroform (1d d-trichloroethane) Mas identified as a major component in two fabric-protector spray products, tkjtagenic effects were determined at several dosage levels for the two products and some of the identified components. Levels of organics in the air of sealed desiccatorS( used as exposure chambers in modified Salmonella reversion assays, were measured by a gas chromatographic technique. Both fabric protectors and two samples of trichloroethane were mutagenic in strain TA 1535 and one of each was mutagenic in strain TA 100. Other constituentsf such as petroleum distillate and p-dioxane t were nonmutagenic at the tested exposure levels. SL 030266 0 9 m o o o 4 # * "7)0013704 1,1.1-TRICHL0R0ETHANE PAGE 33 SOURCE UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET JOURNAL SUBSET JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH SOURCE Environ Mutagen 1984;6(lK71-80 84105552 Keogh AM Ibels LS Allen DH Isbister JP Kennedy MC Exacerbation of Goodpasture's syndrome after inadvertent exposure to hydrocarbon fumes. Eng Adolescence Aerosols Case Report Environmental Exposure Female Goodpasture's Syndrome/#chemically induced Human Hydrocarbons, Chlorinated/#adverse effects Methylene Chloride/*adverse effects Trichloroethanes/#adverse effects 840312 1984 Jan 21 0007-1447 Br Med J [Clin Res] 188 A M X Zl.542.363.300 6412 288 B4X 71-55-6 (1,1,1-trichloroethane) 75-09-2 (Methylene Chloride) 8405 Br Med J (Clin Res] 1984 Jan 21!288(6412):188 * * # END OF OFFLINE PRINT #**# SL 3026? ft085909 ft ****************tftt**tf***********)Ht#***K*KK*fc*tt*K*KK#*tf******* * #*###*# ft THIS IS AN OFF-LINE BIBLIOGRAPHIC CITATION LIST GENERATED BY * ** MEDLARS II * *# * N.L.M.'S NATIONAL INTERACTIVE RETRIEVAL SERVICE * ** KK 1,1, 1-TRICHLOROETHANE NUMBER OF CITATIONS PRINTED = 33 THIS SEARCH MAS PERFORMED ON THE BACKS0 SORT WAS NOT REQUESTED MAY 20, 1986 FILE. PLEASE SEND THIS LISTING TO ft 1 * k % \ I DIANA DANKO / PPG INDUSTRIES,INC. P.O. BOX 31 BARBERTON, OHIO 49203 SL 030268 II ft ft 0002 Io i# < 1 UNIQUE IDENTIFIER AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH 2 TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT #' 11 SL 030269 1,1,1-TRICHLOROETHANE PAGI 83037715 Mull in LS Krivanek ND Comparison of unconditioned reflex and conditioned avoidance tests in rats exposed by inhalation to carbon monoxide, l>ld-trichloroethane> toluene or ethanol. Eng Alcohol> Ethyl/#adverse effects Anima1 Avoidance Learning/drug effects Behaviori Animal/drug effects Body Teraperature/drug effects Carbon Monoxide/*adverse effects Comparative Study Conditioning (Psychology)/#drug effects Dose-Response Relationshipi Drug Hydrocarbons! Ch1orinated/*adverse effects Male Rats Ratsi Inbred Strains Reflex/*drug effects Toluene/#adverse effects Trichloroethanes/#adverse effects 821216 1982 Jul 0161-813X Neurotoxicology 126-37 M 21.107.567.875 1 3 0AP Author 108-88-3 (Toluene) 630-08-0 (Carbon Monoxide) 66-17-5 (Alcohol, Ethyl) 71-55-6 (1,1,1-trichloroethane) 8302 The sensitivity of unconditioned reflex and conditioned avoidance tests in evaluating behavioral toxicity was compared. Male rats were exposed by inhalation up to four hours to 0, 200, 600, 800 or 1600 ppm carbon monoxide (CO)( 0, 1500, 3000, 6000 or 12,000 ppm 1,1,1-trichloroethane; 0, 800, 1600, 3200, or 6600 ppm toluene! or 0, 6000, 8000, 16,000 or 32,000 ppm ethanol. Animals were tested for behavioral changes at one-half, one, two and four hours during exposure and eighteen hours after exposure ended. In o o o o o o o a a a a a 0001 1,1.1-TRICH LOROETHANE PAGE t^ SOURCE 2 UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING ID NUMBER DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION uneondi tioned reflex testing the presence or absence of specific unconditioned reflexes {such as corneal( placingt grasping and righting reflexes) and simple behaviorpatterns including locomotor activity and coordination were observed. The conditioned reflex task consisted of shock avoidance by lever press following simultaneous light and sound stimuli. Rats began to fail unconditioned reflex tests at 800 ppm COt 3000 ppm trichloroethane> 800 ppm toluene and 8000 ppm ethanol. Decrements in conditioned avoidance were observed at 800 ppm CO> 6000 ppm trichloroethane> 3200 ppm toluene and 8000 ppm ethanol. Neither test was consistently more sensitive than the other in detecting behavioral changes. For both methods> the concentrations at which changes were detected in rats were two to tenfold higher than those reported for human effects. Neurotoxicology 1982 Julj3(1)f126-37 82250989 Lane RW Riddle BL Borrelleca JF Effects of lt2-dichloroethane and 1t1l-thichloroethane in drinking water on reproduction and development in mice. Eng Abnormalities > Drug-Induced/etiology Animal Body Weight/drug effects Drinking Ethylene Dichlorides/*toxicity Female Fetus/#drug effects Hydrocarbons > Chlorinated/#toxicity Litter Size/drug effects Male Mice Mice* Inbred ICR Pregnancy Reproduction/*drug effects Support, U.S. Gov't> P.H.S. Trichloroethanes/*toxicity Water/analysis IT32E507087 820910 1982 May 0091-G08X Toxicol Appl Pharmacol 909-21 03027 si* 000; 1.1,1-TRICH LOROETHANE PAE^H3 ' O' o o m m JOURNAL SUBSET MESH 2 TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH SOURCE 3 UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH 2 TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE CAS REGISTRY NUMBER ENTRY MONTH SOURCE M 21.107.567.875 3 63 vwo 107-06-2 (ethylene dichloride) 71-55-6 (1>1.1-trichloroethane) 7732-18-5 (Water) 8211 Toxicol Appl Pharmacol 1982 May;63t3):A09-21 83288180 Schumann AM Fox TR Watanabe PG A comparison of the fate of inhaled methyl chloroform (1>ll-trichloroethane) following single or repeated exposure in rats and mice Eng Aerosols Animal Bi otransformation Carbon Radioisotopes Comparative Study Hydrocarbons Chlorinated/*metabolism Kinetics Male Mi ce Mice> Inbred Strains Rats Ratst Inbred F344 #Solvents Tissue Distribution Trichloroethanes/administration A dosage #metabolism 831028 1982 Jan-Feb 0272-0590 Fundam Appl Toxicol 27-32 M 21.107.567.875 1 2 FAB 71-55-6 (1>1,1-trichloroethane) 8312 Fundam Appl Toxicol 1982 Jan-Feb;2(1)s27-32 SL 030271 0001 1111-TRICH L0R0ETHANE PAG1 4 UNIQUE IDENTIFIER AUTHOR TITLE m LANGUAGE MESH HEADING MESH HEADING m MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING m DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION m PAGINATION JOURNAL SUBSET JOURNAL SUBSET MESH 2 TREE NUMBER m ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR m CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT m -- # # SOURCE 5 UNIQUE IDENTIFIER AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING 63085905 Pointer J Typewriter correction fluid inhalation! a new substance of abuse. Eng Adolescence Drug Combinations Female Gastrointestinal System/drug effects Human ^Hydrocarbons, Chlorinated Respiratory System/drug effects ^Substance Abuse #Trichioroethanes ^Trichloroethylene 830225 1982 Jul 0731-3810 J Toxicol Clin Toxicol 493-9 A M 21.107.567.875 5 19 KAN Author 71-55-6 (1,1,1-trichloroethane) 79-01-6 (Trichloroethylene) 8304 The first known case of inhalation of liquid typewriter correction fluid (TCF) is reported. Respiratory exposure to TCF can produce coma and death. Treatment is mainly supportive. Clinicians should be alerted to this new form of substance abuse. J Toxicol Clin Toxicol 1982 Jul!19(5):493-9 83081727 Wes terberg E Larsson L The use of automated headspace gas chromatography for determination of 1,1,1-trichloroethane in rat blood and brain tissue. Eng Animal Autoanalys i s *Brain Chemistry Chromatography, Gas/methods Hydrocarbons > Chlorinated/#analysis Male SL 030272 m .m o 000 PAGl 1,1,1-TRICHLOROETHANE o MESH HEADING Rats o MESH HEADING Rats Inbred Strains MESH HEADING Support> Non-U.S. Gov't MESH HEADING MESH HEADING Time Factors Trichloroethanes/#analysis/blood o DATE OF ENTRY 630225 DATE OF PUBLICATION 1982 Nov TITLE ABBREVIATION PAGINATION Int J Environ Anal Chem 233-9 o JOURNAL SUBSET M MESH 2 TREE NUMBER 21.592.363.300 ISSUE/PART/SUPP VOLUME ISSUE 3-9 12 JOURNAL TITLE CODE GR9 ABSTRACT AUTHOR Author CAS REGISTRY NUMBER 71-55-6 (1,1,1-trichloroethane) ENTRY MONTH 8309 ABSTRACT 1,1,1-trichloroethane in blood and brain tissue from rats which had been artificially o ventilated with solvent (8000 ppm) was analysed by automated headspace gas chromatography using a fused silica capillary column. A given concentration of o 1,1,1-trichloroethane in the brain could be correlated with a corresponding concentration in the blood; both the uptake and release of the solvent were quicker in blood than in o brain. No volatile metabolites of the solvent were found. Automated headspace gas chromatographic analysis is a rapid and sensitive technique for the quantitative mQ registration of volatile organic solvents, e.g. of industrial importance, in body fluids and tissues. SOURCE Int J Environ Anal Chem 1982 Nov!12(3-9):233-9 6 UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING m MESH HEADING MESH HEADING 83113587 Balster RL Moser VC Woolverton HL Concurrent measurement of solvent vapor concentrations and effects on operant behavior using a dynamic exposure system. Eng Animal Atmosphere Exposure Chambers Conditioning. Operant/*drug effects Male Mi ce Solvents/analysis/#pharmacodynamics Support> U.S. Gov't, P.H.S. Time Factors Trich1oroe t hanes/pharmacodynamics SL 030273 si i # j m' # # # 10 1I i^ * 0001 1,1,1-TRICH LOROETHANE PAGE ID NUMBER ID NUMBER ID NUMBER DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT SOURCE 7 UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DA-00490 ES-070B7 DA-05164 830324 1982 Dec 0160-5402 J Pharmacol Methods 299-309 M Zl.107.567.875 4 8 K8H Author 71-55-6 (l,l,l-trichloroethane> 8305 A method is described for exposing mice, level--pressing on an operant schedule for water reinforcement. to continuously-generated solvent vapors. Concurrent monitoring of chamber concentration and schedule-controlled behavior allows a correlation of the magnitude and time course for behavioral effects with changes in the levels of solvent exposure. Data are presented showing the acute effects of 1.1.1-trichloroethane over the range of 1000-8000 ppm on behavior maintained by a fixed-ratio 100 schedule of water presentation. Concentratfon-dependent decreases in response rates with a rapid onset and recovery were obtained. J Pharmacol Methodsl982 Dec;8(4):299-309 83112737 Kobayashi H Hobara T Hi rota H Higashihara E Iwamoto S Sakai T [Sensitisation of dog myocardium to epinephrine by 1. 1, 1-trichloroethane] Jpn Animal Arrhythmia/#chemically induced Dogs Dose-Response Relationship, Drug Epinephrine/metabolism/#pharmacodynamics Heart/#drug effects Hydrocarbons> Chlorinated/*adverse effects Myocardium/metabolism Trichloroethanes/adverse effects SL 030274 %w m m m m 00 4 1,1,1-TRICHLOROETHANE o oPA 7 DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH 2 TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH SOURCE 830317 1982 Sep 0047-1879 Scinoyo Igaku 450--4 M 21,252.474.463 5 24 KK9 51-43-4 (Epinephrine) 71-55-6 (1,1,1-trlchloroethane l 8305 Sangyo Igaku 1982 Sep;24(5):450r4 o o oi [ i 8 UNIQUE IDENTIFIER 83044662 AUTHOR Savolainen K AUTHOR Riihim'aki V AUTHOR Laine A o TITLE Biphasic effects of inhaled solvents on human equilibrium. LANGUAGE Eng MESH HEADING Adult o MESH HEADING MESH HEADING Equi1ibrium/#drug effects Human MESH HEADING Male MESH HEADING o MESH HEADING MESH HEADING Solvent s /*pharvnacodynam i cs Time Factors Trichloroethanes/pharmacodynamics MESH HEADING Xylenes/pharmacodynamics DATE OF ENTRY 621218 o DATE OF PUBLICATION INTL STAND SER NO 1982 Sep 0001-6683 TITLE ABBREVIATION Acta Pharmacol Toxicol (Copenh) PAGINATION 237-42 0 JOURNAL SUBSET M MESH 2 TREE NUMBER 21.542.808.224 ISSUE/PART/SUPP 3 VOLUME ISSUE 51 0 JOURNAL TITLE CODE ABSTRACT AUTHOR 1QG Author CAS REGISTRY NUMBER 108-38-3 (3-xylene) CAS REGISTRY NUMBER 71-55-6 (1,1,1-trichloroethane) ENTRY MONTH 8302 ABSTRACT Nine healthy male students were exposed for 4 hours at 6-day intervals to atmospheric concentrations of m-xylene (8.2 mumol/1; 200 p.m.) and 1,1.1-trichloroethane ITCE) (8.2 and 16.4 mumol/1; 200 and 400 p.m.) and also to a combination of 8.2 mumol/1 of xylene and SL 030275 of 16.4 muraol/1 of TCE. The exposures took place during 6 consecutive weeks. Body sway was recorded with the subjects' eyes closed oo .5 1,1.1-TRICH LOROETHANE P, 8 # # # # # SOURCE and open on each day with a strain gauge transducer platform prior to and during the exposures. For the average and for the maximal body sway, the ratio of the sway with the eyes closed to the sway with the eyes open was calculated for each recording. Xylene and TCE at 8.2 mumol/1 in air tended to decrease the ratio, whereas the higher TCE cone-jiitration alone or in combination with xylene Tended to have an opposite effect of the same magnitude. The results support the idea that TCE might exhibit a biphasic pattern of acute effects on the central vestibular system. Pharmacokinetic interactions between xylene and TCE were not observed. Acta Pharmacol Toxicol (Copenh) 1982 Sep;51(3 J237-92 # UNIQUE IDENTIFIER AUTHUP 83092919 Dickerson CL AUTHOR Biesemeier JA TITLE Aspiration of methyl chloroform. LANGUAGE Eng MESH HEADING Animal MESH HEADING Aspiration MESH HEADING Hydrocarbons, Chlorinated/*toxicity # MESH HEADING MESH HEADING Lung/drug effects Male MESH HEADING Organ Weight/drug effects MESH HEADING Rats # MESH HEADING DATE OF ENTRY Trichloroethanes/#toxfcity 821221 DATE OF PUBLICATION 1982 Jun INTL STAND SER NO 0195-6296 # TITLE ABBREVIATION PAGINATION Vet Hum Toxicol 167-8 JOURNAL SUBSET M MESH Z TREE NUMBER Zl.107.567.875 ISSUE/PART/SUPP 3 VOLUME ISSUE 29 JOURNAL TITLE CODE XBV CAS REGISTRY NUMBER 71-55-6 (1,1,1-trichloroethane ) ENTRY MONTH 8302 SOURCE Vet Hum Toxicol 1982 Jun!29(3):l67-8 # SL 030276 oo^mib 1,1,1-TRICHLOROETHANE P9 o w c o Q m m u 10 UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH SOURCE UNIQUE IDENTIFIER AUTHOR AUTHORAUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING 83023741 Koi2Urni A Kuma i (1 Ikeda M In vivo suppression of lilfl-trichloroethane metabolism by co-administered tetrachloroethylene: an inhalation study. Eng Air Pollutants/#toxicity Air Pollutants> Occupational/*toxicity Animal Atmosphere Exposure Chambers Drug Interactions Hydrocarbons > Chlorinated/#metebolism Male Rats Ratsi Inbred Strains Tetrachloroethylene/*pharmacodynamics/urine Trichloroethanes/Kmetabolism/urine 821216 1982 Aug 0007-4861 Bull Environ Contain Toxicol 196-9 M Zl.107.567.875 2 29 BFN 127-18-4 (Tetrachloroethylene) 71-55-6 fIdtl-trichloroethane) 8302 Bull Environ Contain Toxicol 1982 Aug;29(2):196-9 83010432 Geller I Mendez V Hartmann RJ Gause E Rippstein WJ Jr Effects of ljl>l-trichloroethane on a match-to-sample discrimination task in the baboon, Eng Animal Atmosphere Exposure Chambers Dose-Response Relationship Drug Hydrocarbons > Chiorinated/*pharmacodynamf cs Male Pap to Perception/#drug effects SL 030277 00 7 # 1,1,1-TRICHLOROETHANE PAl 10 # MESH HEADING Reaction Time/#drug effects MESH HEADING Support, U.S. Gov't, Non-P.H.S. MESH HEADING Tr i chloroe thanes/*pharmacodynam i cs 0 DATE OF ENTRY DATE OF PUBLICATION 821202 1982 May-Jun INTL STAND SER NO 0098-9108 TITLE ABBREVIATION J Toxicol Environ Health PAGINATION 783-95 JOURNAL SUBSET M MESH Z TREE NUMBER Zl.107.567.875 ISSUE/PART/SUPP 5-6 m VOLUME ISSUE JOURNAL TITLE CODE 9 KAA ABSTRACT AUTHOR Author CAS REGISTRY NUMBER 71-55-6 (1,1,1-trichloroethane) m ENTRY MONTH ABSTRACT 8301 1,1,1-trtchloroethane was evaluated for its effects on the delayed match-to-sample discrimination task in juvenile baboons. m Acute 9-h exposures to 700, 1900, 1800, and 2100 ppm were conducted no more frequently than once a week. Three months later a subchronic exposure to 1200 ppm was conducted over a 7-d period in the same animals. The effects on accuracy of responding were minimal; however, 1,1,1-trichloroethane reduced the number of trials attempted by the animals, reduced the number of extra inconsequential responses during the delay intervals, and increased reaction times. The findings of these experiments illustrate the m usefulness of the young baboon as a primate human surrogate model for testing this type of central nervous system depressant. SOURCE J Toxicol Environ Health 1982 # May-Jun;9< 5-6 :763-95 UNIQUE IDENTIFIER 82262671 AUTHOR Thiele DL 0 AUTHOR AUTHOR Eigenbrodt EH Mare AJ TITLE Cirrhosis after repeated trichloroethylene and 1,1,1-trichloroethane exposure. LANGUAGE 0 MESH HEADING Eng Adult MESH HEADING Case Report MESH HEADING Human MESH HEADING W MESH HEADING Hydrocarbons, Chlorinated/#adverse effects Liver/pathology MESH HEADING Liver Cirrhosis/*chemically induced/diagnosis pathology # MESH HEADING MESH HEADING Male Occupational Diseases/chemically induced 030278 SL 0001 1.1>1-TRICH L0R0ETHANE PAGE i rs O O O a o i !9 i i i# r> MESH HEADING MESH HEADING MESH HEADING MESH HEADING ID NUMBER DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH SOURCE diagnosis/pj*hology Support > Non-U.S. Gov't Supporti U.S. Gov'ti P.H.S. Trichloroethanes/#adverse effects Trichloroethylene/*adverse effects 5 T32 AMO7100 821021 1982 Oct 0016-5085 Gastroenterology 926-9 A M Zl.107.567.875 9 83 FH3 71-55-6 (1i1>1-trichloroethane) 79-01-6 CTrichloroethylene) 8212 Gastroenterology 1982 Oct J83( 9) 1926 13 UNIQUE IDENTIFIER 82255967 AUTHOR Savolainen K AUTHOR Ri ihim"aki V AUTHOR AUTHOR Laine A Kekoni J TITLE Short-term exposure of human subjects to m-xylene and 1.1.1-trichloroethane, LANGUAGE MESH HEADING MESH HEADING Eng Adult Equilibrium/drug effects MESH HEADING Human MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING Hydrocarbonsi Chiorinated/#toxici ty Male Reaction Time/drug effects Time Factors Trichloroethanes/#toxicity Xylenes/blood/#toxicity DATE OF ENTRY 820917 DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION 1982 0171-9750 Arch Toxicol tSupplJ PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER VOLUME ISSUE 96-9 M Zl.542.315.570 5 JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER 8J8 Author 108-38-3 t3-xylene) CAS REGISTRY NUMBER 71-55-6 (l>ll-trichloroethane) ENTRY MONTH 8211 ABSTRACT inhalation exposure of male volunteers to SL 030279 hi o O o a a a & m m i 0001 1,1,1-TRICHLOROETHANE PAG I a # 9 l,\ m #' a o u _ ,, # SOURCE UNIQUE IDEN1IFIER AUTHOR AUTHOR TITLE LANGUAGE, MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH 2 TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE BI m-xylene 18.2 mumol/1 , 200 ppm) and 1,1,1-trichloroethane (TCE) (8.2 and 16.A mumol/1, 200 and 400 ppm), as well as to a combination of TCE (16.4 raumol/1) and xylene (8.2 mumol/1), induced only slight changes in psychophysiological functions such as body sway and reaction time. Exposure to the 8.2 mumol/1 concentration of xylene or TCE tended to improve the performances, whereas TCE exposure at 16.4 mumol/1 alone or in combination with xylene tended to have an opposite effect. The results thus suggest a biphasic acute effect of TCE on the central nervous system (CNS) and reveal that xylene and TCE together exhibit neither kinetic interaction nor synergistic nor antagonistic acute effects on the CNS functions studied. Arch Toxicol tSuppl] 198255:96-9 82207171 Poliak JK Harsas W Effects of organochlorine compounds on lipid catabolism of foetal rat liver mitochondria and microsomes. Eng Animal Chlorphenamidine/toxicity Female Hydrocarbons > Chlorinated/*pharmacodynamics In Vitro Lipids/*metabolism Liver/embryology Microsomes, Liver/#raetabolism Mitochondria, Liver/*metabolism Phospholipids/me t abolism Pregnancy Proteins/metabolism Rats Rats, Inbred Strains Support, Non-U.S. Gov't Trichloroethanes/pharmacodynamics 2,4,5-Trichlorophenoxyacetic Acid pharmacodynamics 820826 1982 Mar 0007-4861 Bull Environ Contain Toxicol 313-8 M Zl.107.567.875 3 28 SL 030280 m mW * w % <4 u 0001 1,1,1-TRICH LOROETHANE PAGI JOURNAL TITLE CODE CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH SOURCE BFN 6169-98-3 (Chlorphenamidine) 71-55-6 (1,1,1-trichloroethane) 93-76-5 <2,9,5-Trichlorophenoxyacetic Acid) 8210 Bull Environ Contain Toxicol 1982 Mar ;28( 3):313-8 UNIQUE IDENTIFIER 82192962 AUTHOR York RG AUTHOR Sowry BM AUTHOR Hastings L AUTHOR Manson JM TITLE Evaluation of teratogenicity and neurotoxicity with maternal inhalation o LANGUAGE exposure to methyl chloroform. Eng MESH HEADING Analysis of Variance MESH HEADING Animal MESH HEADING o MESH HEADING Behavior, Animal/#drug effects Body Weight/drug effects MESH HEADING Female MESH HEADING Fetal Death/chemically induced o MESH HEADING MESH HEADING Hydrocarbons, Chlorinated/#toxicity Male MESH HEADING Motor Activity/drug effects MESH HEADING Pregnancy Q MESH HEADING HESH HEADING ^Prenatal Exposure Delayed Effects Rats MESH HEADING Support, U.S. Gov't, P.H.S. MESH HEADING ^Teratogens O MESH HEADING MESH HEADING Time Factors Trichloroethanes/administration dosage #toxicity ID NUMBER ES01601 Q ID NUMBER DATE OF ENTRY ESG0159 820708 DATE OF PUBLICATION 1982 Feb INTL STAND SER NO 0098-9108 TITLE ABBREVIATION PAGINATION J Toxicol Environ Health 251-66 JOURNAL SUBSET M MESH 2 TREE NUMBER 21.107.567.875 ISSUE/PART/SUPP 2 VOLUME ISSUE 9 JOURNAL TITLE CODE KAA CAS REGISTRY NUMBER 71-55-6 C1,1,1-trichloroethane) m ENTRY MONTH SOURCE 8209 J Toxicol Environ Health 1982 Febi9(2)J251-66 SL 030281 0001 0 1,111-TRICH LOROETHANE PAGSPI4 m Q 16 UNIQUE IDENTIFIER 82177008 AUTHOR Schumann AM AUTHOR Fox TR AUTHOR 0 TITLE Watanabe PG tlAC] Methyl chloroform (111fl-trichloroethane 1: pharmacokinetics in rats and mice following inhalation exposure. 0 LANGUAGE MESH HEADING Eng Animal * MESH HEADING Gases MESH HEADING Hydrocarbons. Chlorinated/*metabolism 0 MESH HEADING MESH HEADING Kidney/drug effects Kinetics MESH HEADING Male MESH HEADING Metabolic Clearance Rate 0 MESH HEADING MESH HEADING Mi ce Rats MESH HEADING Rats* Inbred F399 MESH HEADING Species Specificity 0 MESH HEADING MESH HEADING Tissue Distribution Tr ichloroethanes/#metabolism DATE OF ENTRY 820621 DATE OF PUBLICATION 1982 Mar 15 0 INTL STAND SER NO TITLE ABBREVIATION 0091-008X Toxicol Appl Pharmacol PAGINATION 390-901 JOURNAL SUBSET M 0 MESH 2 TREE NUMBER ISSUE/PART/SUPP 21.107.567.875 3 VOLUME ISSUE 62 JOURNAL TITLE CODE VWO Q CAS REGISTRY NUMBER ENTRY MONTH 71-55-6 f1,1,1-trichloroethane) 8208 SOURCE Toxicol Appl Pharmacol 1982 Mar 15i62(3)!390-401 17 UNIQUE IDENTIFIER AUTHOR AUTHOR 0 AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING 0 MESH HEADING MESH HEADING MESH HEADING MESH HEADING a MESH HEADING 82166916 Caperos JR Dros PO Hake CL Humbert BE Jacot-Guillarmod A 1flfl-Trichloroethane exposuref biologic monitoring by breath and urine analyses. Eng Breath Tests Environmental Exposure Hydrocarbons > Chlorinated/*metabolism Kinetics Modelst Biological Support. Non-U.S. Gov't Trichloroacetic Acid/metabolism m m % 030282 0 0 000 PAGI 1.1,1-TRICH LOROETHANE u ] 1 1w? ' O' LJ rV-*s o MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT o r. o 0 0 0 SOURCE TM' IS UNIQUE IDENTIFIER AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING 0 ' * Tri chloroe thanes /#metabol ism/urine 620614 1932 Feb 0340-0130 Int Arch Occup Environ Health 293-303 M 21.542.315.570 3-4 49 GPN Author 71-55-6 (lilil-trichloroethane) 76-03-9 (Trichloroacetic Acid) 8208 Absorption and excretion of 1>1>1-trichloroethane, as well as the kinetics of formation and elimination of trichloroethanol. (TCE) and trichloroacetic acid (TCA) were simulated by a mathematical model. The results of this model were compared with experimental one on pulmonary elimination of the solvent and urinary excretion of the metabolites. The influences of duration and repetition of exposure on the pulmonary and urinary eliminations were studied. A tentative method of biologic monitoring is proposed. Theoretically> the most suitable method of biologic monitoring is proposed. Theoretically> the most suitable method to estimate the exposure is by two determinations! before and after a work shift. Following this procedure! analysis of TCE in the urine is more sensitive than determination of 1,1>1-trichloroethane in the breath. As an indicator of exposure riski TCA is not considered sensitive enough if variations in the inspired concentration occur. Int Arch Occup Environ Health 1982 Febi49( 3-41:293-303 ' 82160756 Guillemin M Gub'eran E Value of the simultaneous determination of PC02 in monitoring exposure to 1ilil-trichloroethane by breath analysis. Eng Adult Analysis of Variance Breath Tests/instruraentation/*methods Carbon Dioxide/*analysis SL 030283 0 0 0 0 m m m VP 000 PAG 6 1,1,1-TRICHLOROETHANE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT SL 030284 SOURCE Comparative Study Environmental Exposure Human Hydrocarbons, Chlorinated/*analysis Male Middle Age Partial Pressure Solvents/#analysis Trichloroethones/analys1s 620624 1962 May 0007-1072 Br J Ind Med 161-8 M Z1.542.363.300 2 39 AXS Author 71-55-6 (1,1,1-trichloroethane) 8206 Eight volunteers were exposed -for eight hours to about 200 ppm of 1,1,1-trichloroethane. On the next morning five series of five alveolar samples were collected for the simultaneous determination of PC02 and 1.1.1- trichloroethane concentration. Three different methods of sampling were used: voluntary hyperventilation, 10-s breathholding, and ''standard." A linear relationship between the alveolar concentrations of both gases was observed in all subjects. Expired air was also collected in two subjects and an analogous relationship was observed. Also the Bohr dead space was found to be of similar sire for C02 and for 1.1.1- trichloroethane. In the monitoring of solvent exposure by breath analysis it is suggested that the results should be corrected for hyperventilation or hypoventilation and for dilution of alveolar air with dead space air by a proportional adjustment of the solvent concentration sit the mean normal adveolar PCQ2 or by disregarding the samples with a PC02 outside normal range. The PC02 determination in 40 unselected workers has shown that in more than a third of them, to monitor exposure by breath analysis would have been of little meaning without such an adjustment or rejection criteria. Br J Ind Med 1982 MayI39(2)U6I-8 000| o 1,1,1-TRICHLOROETHANE PAi .7 a o UNIQUE IDENTIFIER 82172462 u AUTHOR Reid KJ AUTHOR Young FJ o TITLE Are trichloroethane-based substitutes safer than xylene? tietter] id LANGUAGE Eng MESH HEADING Human o MESH HEADING MESH HEADING Hydrrrarbons t Chlorinated/#toxieity Maximum Permissible Exposure Level id MESH HEADING Safety MESH HEADING Trichloroethanes/*toxicity MESH HEADING DATE OF ENTRY Xylenes/*toxicity 620624 % DATE OF PUBLICATION 1981 Mar INTL STAND SER NO 0308-3616 o TITLE ABBREVIATION PAGINATION Med Lab Sci 145-9 m MESH Z TREE NUMBER Zl.542.363.300 ISSUE/PART/SUPP 2 o VOLUME ISSUE JOURNAL TITLE CODE 38 MA5 m CAS REGISTRY NUMBER 71-55-6 tIt 1l-tr1chloroethane) ENTRY MONTH 8208 SOURCE Med Lab Sci 1981 Mar!38(2):i45-9 UNIQUE IDENTIFIER 82129964 AUTHOR ` Carlson GP a TITLE Effect of alterations in drug metabolism on epinephrine-induced cardiac arrhythmias in rabbits exposed to methylchloroform. LANGUAGE Eng m MESH HEADING MESH HEADING Animal Antimetabolites/pharmacodynamics MESH HEADING Arrhythmia/#chemically induced MESH HEADING Biphenyl Compounds/pharmacodynamics MESH HEADING w MESH HEADING Comparative Study Diethylamines/pharmacodynaraics MESH HEADING Epinephrine/*pharmacodynamics MESH HEADING Ethylene Chlorohydrin/analogs t derivatives w MESH HEADING blood Hydrocarbons > Chlorinated/*toxicity % MESH HEADING Male MESH HEADING Phenobarbital/pharmacodynaraics MESH HEADING Proadifen/pharmacodynamics MESH HEADING Rabbits MESH HEADING Support t U.S. Gov`11 P.H.S. MESH HEADING Trichloroacetic Acid/blood MESH HEADING Triehloroethanes/blood/toxicity ID NUMBER IGM23402 ID NUMBER I/T35GM07686 DATE OF ENTRY DATE OF PUBLICATION 820412 1981 Dec _____ SL 030285 W' 5( 00(^H5 o 1,1,1-TRICHLOROETHANE PA^HLS INTL STAND SER NO TITLE ABBREVIATION LAST REVISION DATE RECORD ORIGINATOR PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP a VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER Q CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER O CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH O ABSTRACT O O o SOURCE 21 UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR TITLE \ a o ii LANGUAGE MESH HEADING MESH HEADING 03186 0378-4274 Toxicol Lett 620720 M3MYA 307-13 M Zl.542.651 4 9 VXN Author 107-07-3 < Ethylene Chlorohydrln) 115-20-8 (2,2,2-trichloroethanolt 2600-77-3 (Lilly 18947) 302-33-0 (Proadifen) 50-06-6 (Phenobarbital3 51-43-4 (Epinephrine) 71-55-6 (11>1-trichloroethane) 76-03-9 (Trichloroacetic Acid) 8206 Control rabbits or those treated with the drug-metabolism inducer> phenobarbitolt or the inhibitorsi 2-diethylaminoethyl-2*2-diphenylvalerate-HCI (SKF-525A) or 2.4-dichloro-6-phenylphenoxyethyldiethyl-amine-HBr (Lilly 18947) were exposed to 5600 ppin methylchloroform in an inhalation chamber under dynamic airflow conditions. Phenobarbital treatment slightly decreased blood levels of methylchloroform and the incidence of cardiac arrhythmias. The two inhibitors decreased the metabolism of methylchloroform and increased the incidence of arrhythini as . Methylchloroform rather than its metabolites appeared responsible for the arrhythmias. This arrhythmogenicity was altered by agents which affect the disposition and hence the blood levels of the compound. Toxicol Lett 1981 Dec !9(4): 307-13 82129901 Elias Z Hartemann P Chau N (A study of the cytotoxicity of chloroformt 1-2-dichloroethanet 1lt1-trichloroethane and hexachlorobutadiene to mouse L cells (author's transl)) Fre Animal Antifungal Agents/#pharmacodynamics 5 t &1 i ! u Q 000 1,1,1-TRICHLOROETHANE PAG^Pi9 <8* O MESH HEADIMG Butadi enes /*pharmacodynarn 1 cs MESH HEADING Cell Survival/drug effects MESH HEADING Chloroform/xpharmacodynamics MESH HEADING o MESH HEADING Dose-Response Relationship, Drug English Abstract & MESH HEADING Ethylene Di chloHdes/#pharmacodynatni cs MESH HEADING Hydrocarbons, Chlorina t ed/#pharmacodynam jcs MESH HEADING w MESH HEADING L Cells/drug effects/physiology Mi ce * MESH HEADING Trichloroet hanes/xpharmacodynamics DATE OF ENTRY 820420 DATE OF PUBLICATION 1981 Nov o TITLE ABBREVIATION Toxicol Eur Res 8* PAGINATION 293-8 JOURNAL SUBSET M MESH 2 TREE NUMBER 21.592.286 u ENG ABSTR IND A ISSUE/PART/SUPP 6 TRANSLIT/VERNAC TITLE Etude de la cytotoxicit'e du chloroforme, du dichloro-1,2- 'ethane, du trichloro-1>1,1-'ethane et de 1'hexaehlorobutadi`ene sur les cellules L de souris. VOLUME ISSUE JOURNAL TITLE CODE 3 VHD # ABSTRACT AUTHOR Author CAS REGISTRY NUMBER 107-06-2 (ethylene dichloride) CAS REGISTRY NUMBER 67-66-3 (Chloroform) CAS REGISTRY NUMBER 71-55-6 (1,1>l-trfchloroethane) CAS REGISTRY NUMBER 87-68-3 (hexaehlorobutadiene) ENTRY MONTH 8206 ABSTRACT A cytotoxicity test based on residual protein determination is described and the in vitro toxicity of certain chlorinated aliphatic hydrocarbons is evaluated with this test. The m results obtained are sufficiently reproducible to yield an order of cytotoxicity! hexaehlorobutadiene is about 100-fold more toxic than chloroform or 1>2-dichloroethane; whereas, 1,1,1-trichloroethane is 10-fold more toxic than these two compounds. The method is fast and lends itself to the toxic evaluation of large numbers of samples. SOURCE Toxicol Eur Res 1981 Nov;3(6):293-8 # SL 030287 * 0 ,. 000^^7 Q 1,1,1-TRICH L0R0ETHANE paJ^^ 0 r 22 UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR W' AUTHOR AUTHOR TITLE vj LANGUAGE MESH HEADING w*' S MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING J MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO O TITLE ABBREVIATION PAGINATION MESH 2 .TREE NUMBER ISSUE/PART/SUPP o VOLUME ISSUE JOURNAL TITLE CODE CAS REGISTRY NUMBER ENTRY MONTH /w'> SOURCE 23 UNIQUE IDENTIFIER AUTHOR ' "l AUTHOR AUTHOR TITLE - \ LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING 82103471 Viola A Si gon M Pittoni G Sarto F Pennel1i N Serum enzyme activities and histological changes after percutaneous application of methylchloroform. Eng Animal Enzymes/^blood Hydrocarbons > Chlorinated/toxic(ty Liver/drug effects/pathology Male Rats Ratsi Inbred Strains Skin Absorption/drug effects Time Factors Trichloroethanes/#toxicity 820313 1981 Sep-Oct 0025-7818 Med Lav 410-5 21.542.489 5 72 M4U 71-55-6 11>li1-trichloroethane 1 8205 Med Lav 1981 Sep-Oct;72(5):410-5 62101523 Kobayashi H Hobara T Sakai T [A role of the autonomic nervous system in alterations of blood pressure and heart rate induced by li 1> 1-trichloroethane (author's transl)] Jpn Animal Atropine/pharmacodynamics Autonomic Nervous System/physiology Blood Pressure/*drug effects Dogs English Abstract Heart Rate/drug effects Hydrocarbons, Chlorinated/toxicity Kidney/innervation Male SL 030288 m m 0 0mj| 0 CJ o w a w # m # m # u 00 :8 1,1> 1 -TRICH LOROETHANE P, MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ENG AB5TR IND ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT Trichloroethanes/*toxicity Vagotomy 620313 1981 Jul Sangyo Igaku 401-6 M Zl. 252.474.463 A 4 23 KK9 Author 51-55-8 (Atropine) 71-55-6 (lll-trichloroethane) 8205 An experiment was conducted to clarify effect of 1 It 1- trichloroethane (It It 1-TCE) on blood pressure and heart rate( and to investigate the role of the autonomic nervous system in these responses. Adult mongrel dogs were anesthetized with sodium pentobarbital (25-30 mgAgt i. v.) and the respiration was maintained artificially with positive pressure ventilation. Fifty mg/kg of It It 1-TCE was intravenously injected. The left kidney was exposed by flank incisiom and discharges of efferent renal sympathetic nerve were recorded using bipolar platinum electrodes. It It 1-TCE induced 39.6 +/- 3.IX (mean +/- S. E.) diminution in systemic blood pressure compared to each pre-administration levelt but the blood pressure gradually returned to the control level in the vagi intact group. A fall in blood pressure to 39.3 +/- 5.IX level was induced by It It 1-TCE in the group which had been bilaterally vagotomized or treated with atropinei but it was not significantly different from that in the vagi intact group. Immediately after the administration of It It 1-TCEt heart rate significantly decreased from 122t 3 /- 9.1 to 86 +/- 5.6 beats/min in the vagi intact groupt but remained unchanged in the vagotomy or atropine group. Discharges of efferent renal nerve were augmented and blood pressure fellt after injection of nitroglycerin. A decrease in the discharge of efferent renal sympathetic nerve and an increase in the blood pressure were observed after injection of norepinephrine. On the other handt discharges obviously decreased dispite a fall in the blood pressure after administration of SL 030289 00' 9 1,1,1-TRICH LOROETHANE Pi 22 "I SOURCE \ 24 UNIQUE IDENTIFIER w AUTHOR AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING o MESH HEADING MESH HEADING MESH HEADING MESH HEADING 3 DATE OF ENTRY DATE OF PUBLICATION TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ENG ABSTR IND ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT J II 030290 SL 1) It 1-TCE. This response showed that the decrease of efferent renal sympathetic nerve activity may be related to the fall in the blood pressure after 1* It 1-TCE. On the basis of the results obtainedp it is suggested That the autonomic nervous system may play a major role in the effects of It It 1-TCE on the blood pressure and heart rate in anesthetized dogs. Sangyo Igaku 1981 Jul;23(4):401-6 82101520 Hobara T Kobayashi H Iwamoto S Sakai T [Diminution of It It 1- and It It 2trichloroethane in the blood and their excretion by the lungs (author's transit! Jpn Animal Dogs English Abstract Hydrocarbons t Chlorinated/#metabolism Lung/*metabolism Time Factors Trichloroethanes/blood/#metaboilsm 820313 1981 Jul Sangyo Igaku 377-82 M Zl.252.474.463 A 4 23 KK9 Author 71-55-6 (lilil-trichloroethane) 79-00-5 (l(li2-trichloroethane) 8205 In order to investigate the diminution of It It 1-trichloroethane (It It 1-TCE) and It It 2-trichloroethane (It It 2-TCE) in the blood and the excretion of them by the lungst 100 mg and 50 mg per kg body weight of It It 1-TCE were intravenously administered to 12 and 13 dogst respectively! and the same amounts of It It 2-TCE to 5 and 8 dogst respectively. The arterial blood gathered and the expired air collected by the time up to 60 minutes after the injection were analysed w> th a FID-gas-chromatography for the vy # # m 3J 00 PAI 3 11i1-TRICH LOROETHANE SOURCE UNIQUE IDENTIFIER AUTHOR AUTHOR ' AUTHOR AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO concentrations of the solvents. The results obtained are as follows. 1. Concentrations of Ii 1> 1-TCE in the blood were maintained significantly lower always from 2 to 60 minutes after the injection than those of 1 li 2-TCE. 2. UBiile highest concentrations of the solvents in the expired air were found about I minute after the injection for both It It 1-and It It 2-TCEt values 1 minute after for the former were seven to ten times higher than those for the latter. Howevert no significant differences in the concentration were seen between both solvents after 15-AO minutes of administration in the expired air. 3. Ratios of the amounts expired by the lungs during 60 minutes after the injection to the total were 61-68Ji for li li 1-TCE> whereas only 21-32/i for 1> 1, 2-TCE respectively. A. Highly significant linear regression was found between the concentrations of the solvent in the blood and those in the expired air for each of 1> 1( 1- and 1> 1, 2-TCE. Sangyo Igaku 1981 Jul!231A):377-82 82099309 Nov'akov'a V Musil J Buckiov'a 0 T'aborsk'y 0 Sollov'a H V'yborn'y P Effect of tetrachloromethane and other chlorinated hydrocarbons on the hepatic metabolism in the isolated perfused rat liver. Eng Alanine Arainotransferase/metabolism Animal Aspartate Arainotransferase/metabolism Carbon Tetrachloride/*pharmacodynamics Chloroform/pharmacodynamics Hydrocarbons > Chlorinated/*pharmacodynamics Iditol Dehydrogenase/metabolism Liver/*enzymology Male Methylene Chloride/pharmacodynamics Phenobarbital/pharmacodynamics Rats Rats> Inbred Strains Trichloroethanes/pharmacodynamics Trichloroethylene/pharmacodynamics 820322 1981 0022-1732 m m m $ & & m # SL 030291 # 1 0001 O 1.1,1-TRICHLOROETHANE PAI A \ > f TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH SOURCE 26 UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP J Hyg Epidemiol Microbiol Immunol 369-63 M ZI.542.243.301 4 25 IEV EC 1.1.1.14 (Iditol Dehydrogenase) EC 2.6.1.1 (Aspartate Aminotransferase) EC 2.6.1.2 (Alanine Aminotransferase) 50-06-6 (Phenobarbital) 56-23-5 (Carbon Tetrachloride) 67-66-3 (Chloroform) 71-55-6 (1,1,1-trichloroethane) 75-09-2 (Methylene Chloride) 79-01-6 (Trichloroethylene) 8205 J Hyg Epidemiol Microbiol Immunol 1981)25(4) J 369-83 82084401 Toftg'ard R Nilsen QG Gustafsson JA Changes in rat liver microsomal cytochrome P-450 and enzymatic activities after the inhalation of n-hexane, xylene, methyl ethyl ketone and methylchloroform for four weeks. Eng Androstenedione/metabolism Animal Butanones/toxicity Cytochrome P-450/*metabolism Hexanes/toxicity Hydrocarbons > Chlorinated/toxicity In Vitro Male Microsomes > LIver/#enzymology Organ Weight/drug effects Rats Ratsi Inbred Strains Solvents/*toxicity Support, Non-U.S. Gov't Trichloroethanes/*toxicity Xylenes/toxicity 5-Androstane-3,17-diol/metabolism 820222 1981 Mar Scand J Work Environ Health 31-7 M Zl.542.808.380 1 si- 0 00013^^ 1,1,1-TRICHLOROETHANE PAGE 0 0 0 VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR 90 CAS REGISTRY NUMBER CAS REGISTRY NUMBER CA3 REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT # # m m m m m m ~ SOURCE 27 UNIQUE IDENTIFIER AUTHOR AUTHOR AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING 0 '* < 7 UEB Author 11Q-54-3 (n-Hexane) 5126-76-5 (5-Androstane-3,17-diol) 63-05-8 (Androitenedione) 71-55-6 (1,1,1-trichloroetlwn) 78-93-3 (methylethyl KetoneJ 9035-51-2 (Cytochrome P-450J 8204 Groups of Sprague-Dsnley rats were exposed, by inhalation, to n-hexane (900 ppm, 3,240 mg/in 3), xylene (600 ppm, 2,625 mg/m3)> methyl ethyl Ketone (800 ppm, 2,345 mg/m3) and methylchloroform (800 ppm, 4,345 mg/m3) for four weeks. Increased liver weights and liver to body weight ratios were observed for all the solvents except n-hexane. An increased in vitro formation of certain metabolites of all the investigated substrates was found only in the rats exposed to xylene. The in vitro microsomal metabolism of biphenyl, benso(aIpyrene, 4-androstene-3,17-dione and 4 alpha-androstane-3 alpha, 17 beta-diol In combination with sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed that n-hexane was without effect on rat liver microsomal cytochrome P-450 and that methyl ethyl Ketone and methylchloroform depressed the formation of two metabolites of androstenedione but did not alter the concentration of cytochrome P-450 under the experimental conditions used. Xylene was shown to be a phenobarbital-liKe inducer of rat liver microsomal cytochrome P-450. Scand J WorK Environ Health 1981 Mar;7U):31-7 82052104 Savolainen K Riihim'aki V Laine A Kekoni J Short-term exposure of human subjects to m-xylene and 1,1,1-trichloroethane. Eng Adult Eye Movements/drug effects Fingers FlicKer Fusion/#drug effects Human Hydrocarbons, Ch1orinated/*pharmacodynamics Male Movement/drug effects m 0 m 0 m m 0 0 0 m m SL 030293 0 00013' 1,1>1-TRICH LOROETHANE PAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT SOURCE #Posture Reaction Time/*drug effects Trichloroethanes/blood/#pharmacodynamics Veins Xylenes/blood/*pharmacodynami cs 600109 1981 0340-0130 Int At' eh Occup Environ Health 89-96 M 21.542.315.570 1 49 GPN Author 108-38-3 (meta-xylene) 71-55-6 (l>l>l-trichloroethane) 8203 Nine healthy male students were exposed to singular atmospheric concentrations of m-xylene (8.2 mumol/l; 200 ppm) or 1*1>l-trichloroethane (TCE) (8.2 and 16.4 mumol/l> 200 and 400 ppm) * and also to a combination of xylene (8.2 mumol/l) and TCE (16.4 mumol/l) for 4 h per day at 6-day intervals. The effects of the atmospheric xylene and TCE concentrations on psychophysiological functions such as reaction time* body balance and CFF thresholds were studied. The exposures to xylene alone and to the lower TCE concentrations usually tended to improve the performances* whereas the higher TCE concentration alone or in combination with xylene tended to have an opposite effectt although statistically significant changes in performance* as compared to the control values* were rare. The results thus suggest a biphasic effect of TCE on the central nervous system (CNS)* slight stimulation of the CNS at lower and depression at higher TCE concentrations. The results also revealed that xylene and TCE together exhibited neither kinetic interaction nor synergistic nor antagonistic effects on the CNS functions studied. Int Arch Occup Environ Health I98i;49(I):89-98 03029* SL 00 m 1,1,1-TRICHLOROETHANE PA! 7 m 28 UNIQUE IDENTIFIER 82025898 AUTHOR Ivanetich KM AUTHOR Van den Honert LH TITLE Chloroethanes J their metabolism by hepatic cytochrome P-450 in vitro. LANGUAGE Eng MESH HEADING Animal MESH HEADING Antimetabolites/pharmacodynamics MESH HEADING Bitransformation MESH HEADING Cytochrome P-450/*metabolism MESH HEADING Ethane/analogs fc derivatives/metabolism MESH HEADING Hydrocarbons * Chlorinated/*metebolism MESH HEADING Hydrogen Perox i de/tne taboi i sm MESH HEAOINS In Vitro MESH HEADING Kinetics MESH HEADING Male MESH HEADING Microsomes > Liver/*enzymology MESH HEADING NAOP/metabolism MESH HEADING Oxidation-Reduct i on m MESH HEADING MESH HEADING Rats Support* Non-U.S. Gov't MESH HEADING Trichioroethanes/#metabolism DATE OF ENTRY 811215 # DATE OF PUBLICATION INTL STAND SER NO 1981 0143-3334 TITLE ABBREVIATION Carcinogenesis PAGINATION 697-702 m JOURNAL SUBSET MESH 2 TREE NUMBER M Zl.107.567.875 ISSUE/PART/SUPP 8 VOLUME ISSUE 2 JOURNAL TITLE CODE C9T ABSTRACT AUTHOR Author CAS REGISTRY NUMBER 53-59-8 (NADP) CAS REGISTRY NUMBER 71-55-6 (1,1,1-trichloroethane> CAS REGISTRY NUMBER 74-84-0 (Ethane) CAS REGISTRY NUMBER 7722-84-1 (Hydrogen Peroxide) CAS REGISTRY NUMBER 79-00-5 (l*li2-trichloroethane) CAS REGISTRY NUMBER 79-34-5 (1,1,2,2-tetrachloroethane ) CAS REGISTRY NUMBER 9035-51-2 (Cytochrome P-450) ENTRY MONTH 8202 ABSTRACT 1*1*1- and l*l*2-trichloroethane and l*l*2*3-tetrachloroethane stimulate CO- inhibitable NADPH oxidation by hepatic microsomes. Incubation of the chloroethanes* hepatic microsomes* an NADPH-generating system and EDTA results in the production of m chlorinated metabolites. Both NADPH oxidation and metabolite production are inhibited by CO* SKF 525A and/or metyrapone The induction of cytochrome P-450 with phenobarbital enhances the binding and metabolism of the SL 030295 0000^HE5 o 1,1.1-TRICHLOROETHANE P 28 SOURCE UNIQUE IDENTIFIER AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET MESH 2 TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE ABSTRACT AUTHOR CAS REGISTRY NUMBER ENTRY MONTH ABSTRACT SL 030296 chloroalkanes> while the induction of cytochrome P-448 with beta-naphthoflavone does not. 1>1,1-trichloroethane is converted to 2>2>2-trichloroethanol by hepatic microsomal cytochrome P-450> while the major metabolites of 1,1,2-trichloroethane and l,l>22-tetrachloroethane from this enzyme system are mono- and dichloroacetate> respectively. Mechanisms for the production of these metabolites are suggested. The relative mutagenic and carcinogenic potentials of the three chloroethanes are considered with respect to their relative extents of metabolism and their proposed metabolic pathways. Carefnogenesis 1981!2(81=697-702 82021986 Gerace RV Near-fatal intoxication by 1> lt 1-trichloroethane. Eng Case Report Chi Idi Preschool Human Hydrocarbons, Chlorinated/#poisoning Male Trlchloroethanes/#poisoning Volatilization 311122 1981 Oct 0196-0644 Ann Emerg Med 533-4 M Zl.107.567.675 10 10 4Z7 Author 71-55-6 t1>1>l-trichloroethane) 6201 This report describes a case of near-fatal intoxication following accidental exposure to li 1> 1-trichloroethane in a child. This solventi generally safe* is widely used to ! 1* 1-trichloroethane in a child. This solvent, generally safe> is widely used in industrial and domestic preparations. Exposure to high levels of vapor can result in respiratory depression and/or fatal dysrhythmias. Treatment is generally supportive. Ventilation is maintained to 00 0 [6 1,1,1-TRICH LOROETHANE. PAdVS9 SOURCE UNIQUE IDENTIFIER AUTHOR AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION INTL STAND SER NO TITLE ABBREVIATION PAGINATION MESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH SOURCE 31 UNIQUE IDENTIFIER AUTHOR TITLE LANGUAGE MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING MESH HEADING DATE OF ENTRY DATE OF PUBLICATION enhance respiratory excretion. Ann Emerg Med 1981 Oct ilOUO) :533-4 61263525 Ogata M Hasegauia T Effects of chlorinated aliphatic hydrocarbons on mitochondrial oxidative phosphorylation in the rat with reference to the effects of chlorinated aromatic hydrocarbons. Eng Animal Hydrocarbons , Chlor1nated/#toxicity Male Mitochondria> Liver/#drug effects Naphthalenes/toxicity Oxidative Phosphorylation/*drug effects Rats Respiration/drug effects Supporti Non-U.S. Gov't Tetrachloroethylene/toxici ty Trichloroethanes/toxicity Trichloroethylene/toxicity 611025 1981 0019-8366 Ind Health 71-5 Zl.252.474.463 2 19 G9L 127-18-4 tTetrachloroethylene) 630-20-6 (1,1,1,2-tetrachloroethane ) 71-55-6 (111 il-trichloroethane) 79-01-6 (Trichloroethylene) 90-13-1 (1-chloronaphthalene) 8112 Ind Health 1981!19(2):71-5 81198267 Cohen R Organic solvents: avoiding unsafe solutions. Eng Alcohol, Methyl/toxicity Chemistry Human Maximum Permissible Exposure Level Occupational Diseases/*chemically Induced Solvents/#toxicity Trichloroethanes/toxicity 810709 1981 May m\ i* m m m m m m m * SL 030297 i. & ooo1 7 1,1,1 -TRICH LOROETHANE PASiP'SO INTL STAND SER NO TITLE ABBREVIATION PAGINATION JOURNAL SUBSET HESH Z TREE NUMBER ISSUE/PART/SUPP VOLUME ISSUE JOURNAL TITLE CODE CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH SOURCE 0362-4064 Occup Health Saf 14-5, 19, 58 M Zl.107.567.875 5 50 ODE 67-56-1 (Alcohol, Methyl) 71-55-6 (1,1>l-trichloroethane ) 8109 Occup Health Saf 1981 Mayi50(5):i4-5, 19, 58 UNIQUE IDENTIFIER 81116380 AUTHOR Henschler D AUTHOR Reichert D AUTHOR Metzler M TITLE Identification of potential carcinogens in i ) LANGUAGE technical grade 1,1,1-trichloroethane. Eng MESH HEADING Animal MESH HEADING Careinogens/Kanalys i s MESH HEADING Chromatography, Gas MESH HEADING Hydrocarbons, Chiorinated/#analysis MESH HEADING Mass Fragmentography MESH HEADING Mice MESH HEADING Rats MESH HEADING Trichloroethanes/#analysis/toxicity DATE OF ENTRY 810413 DATE OF PUBLICATION 1980 INTL STAND SER NO 0340-0130 TITLE ABBREVIATION Int Arch Occup Environ Health PAGINATION 263-8 JOURNAL SUBSET M MESH Z TREE NUMBER Zl.542.315.570 ISSUE/PART/SUPP 3 VOLUME ISSUE 47 JOURNAL TITLE CODE GPN ABSTRACT AUTHOR Author CAS REGISTRY NUMBER 71-55-6 (1,1,1-trichloroethane ) ENTRY MONTH 8106 ABSTRACT Gas chromatography and gas chromatography-mass spectrometry were employed to analyze 22 samples of technical grade 1,1,1-trichloroethane for impurities. Eighteen contained vinylidene chloride (1,1-dichloroethylene) (30-900 micrograms/ml) and further contaminants were identified as 1,1-dichloroethane (11), trichloroethylene (12), and 1,1,2-trichloroethane (9). Nitromethane (18), 1,2-epoxybutane (19), tert. butanol (7), and dioxane (10) were SL 030298 detected as stabilizers. It is recommended (^TO)055 *##**##*#**##*#*********##**#**##*****##**#**#*#*(******#****#***#* ** * THIS IS AN OFF-LINE BIBLIOGRAPHIC CITATION LIST GENERATED BY * * * * MEDLARS II '* * * N.L.M.'S NATIONAL INTERACTIVE RETRIEVAL SERVICE * # # ** MK***K***tt*KK*M*K*K********ttft'*&*K***K*****K************K*******ttK**** 1,1,1-TRICHLOROETHANE NUMBER OF CITATIONS PRINTED = 1 THIS SEARCH WAS PERFORMED ON THE BACK77 SORT WAS NOT REQUESTED MAY 20, 1986 FILE. I PLEASE SEND THIS LISTING TO ! DIANA DANKO / PPG INDUSTRIES,INC P.0. BOX 31 BARBERTON, OHIO 44203 SL 030300 tt**MK** ***** ***K ******* K* *********** *K K K H tt H ******* tt ******************* THIS IS AN OFF-LINE PRINT GENERATED BY * * * TOXNET * * N.L.M.'S TOXICOLOGY DATA NETWORK * * * ************************************************************************ 1,1.1-TRICHLOROETHANE NUMBER OF CITATIONS PRINTED = I MAY 2I> 1986 THIS SEARCH WAS PERFORMED ON HAZARDOUS SUBSTANCES DATABANK. REQUESTED BY DIANA DANKO PLEASE SEND THIS LISTING TO DIANA M. DANKO PPG INDUSTRIES P. 0. BOX 31 BARBERTON, OHIO A42Q3 f*rz> *&>>**' I,1'1 030302 aaaaaaaaaaaaaaaaaaaaaaaaaaaaaa aaaaaaaaaaaaaaaaaaaaaaa aaaaaaaaa aaaaaaaaaa I f * * * 1* THIS IS AN OFF-LINE PRINT GENERATED BY TOXNET a a a a *a * N.L.M.'S TOXICOLOGY DATA NETWORK a *a *a aaaaaaaaa aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa 1,1,1-TRICHLOROETHANE NUMBER OF CITATIONS PRINTED = I tlAY 21, 1986 THIS SEARCH NAS PERFORMED ON HAZARDOUS SUBSTANCES DATABANK. REQUESTED BY DIANA DANKO PLEASE SEND THIS LISTING TO o DIANA M. DANKO PPG INDUSTRIES P. 0. BOX 31 BARBERTON, OHIO 44203 * # SL 030303 00^6 y 1,1,1-TRICH LOROETHANE 1 HAZARDOUS SUBSTANCES 157 DATABANK NUMBER LAST REVISION DATE 850926 RECORD LENGTH 62751 NAME OF SUBSTANCE 1.1.1- TRICHLOROETHANE CAS REGISTRY NUMBER 71-55-6 SYNONYMS 1)1,1-TRICHLOORETHAAN fDUTCH) SYNONYMS SYNONYMS SYNONYMS 1.1.1- TRICHLORAETHAN (GERMAN) lilt1-TRICLOROETANO (ITALIAN) AEROTHENE TT o SYNONYMS ALGYLEN SYNONYMS SYNONYMS SYNONYMS ALPHA-T ALPHA-TRICH LOROETHANE BALTANA o SYNONYMS CF 2 SYNONYMS SYNONYMS SYNONYMS SYNONYMS CHLOROETENE CHLOROETHANE-NU CHLOROFORM, METHYLCHLOROTENE o SYNONYMS SYNONYMS SYNONYMS SYNONYMS SYNONYMS SYNONYMS SYNONYMS CHLOROTHANE NU CHLOROTHENE CHLOROTHENE NU CHLOROTHENE VG CHLORTEN CHLORTHANE-NU CHLORYLEN o o SYNONYMS ETHANE, 1,1,1-TRICHLORO- SYNONYMS GEMALGENE SYNONYMS SYNONYMS GENKLENE ICI-CF 2 o SYNONYMS INHIBISOL SYNONYMS o SYNONYMS SYNONYMS METHYLCHLOROFORM METHY LTRICH LOROMETHANE NCI-C09626 o SYNONYMS NCI-C09626 SYNONYMS o SYNONYMS SYNONYMS SOLVENT 111 TRI TRICHLORAN 0 SYNONYMS TRICHLORO-1,1,1-ETHANE (FRENCH) SYNONYMS TRICHLOROETHANE o SYNONYMS MOLECULAR FORMULA TRIELENE C2-H3-C13 & WISWESSER LINE NOTATION GXGG1 RTECS NUMBER NIOSH/KJ2975000 o OHM-TADS NUMBER SHIPPING NAME/NUMBER - 8100101 UN2831 (General Electric Co! Material Safety 0 DOT/UN/NA/IMCO Data Sheet *311 tl983)) EPA HAZARDOUS MASTE U226 190 CFR 379. 7/1/83) Q NUMBER METHODS OF MANUFACTURING PREPN: PREPARED BY ACTION OF CHLORINE ON 1.1- DICHLOROETHANE! SUTTON, PROC SOC A133, & SL 30304 #  11 0001 1,1,1-TRICHLOROETHANE PAI 2 METHODS OF MANUFACTURING FORMULATIONS/PREPARATIONS FORMULATIONS/PRE PARATIONS MANUFACTURERS MANUFACTURERS MANUFACTURERS MANUFACTURERS MANUFACTURERS MANUFACTURERS MANUFACTURERS MANUFACTURERS MANUFACTURERS 673 (1931)> BY CATALYTIC ADDITION OF HCL TO 1.1-DICHLOROETHYLENE: GERMAN PATENT 523,936 (1931); US PATENT 2,209,000 (NUTTING, HUSCHER, 1990). (MERCK INDEX 9TH ED 1976 1237) DEHYDROCHLORINATION OF ETHYLENE DICHLORIDE TO VINYL CHLORIDE FOLLOWED BY REACTION WITH HYDROGEN CHLORIDE TO PRODUCE 1.1-DICHLOROETHANE, WHICH IS CHLORINATED; REACTION OF ETHANE A CHLORINE FOLLOWED BY SEPN PLUS RECYCLE OF COPRODUCTS (SRI) REACTS WITH ALUMINUM S ALUMINUM ALLOYS, BUT INHIBITED FORMULAE ARE NOW MARKETED UNDER TRADE NAMES SUCH AS CHLOROTHENE...WHICH CONTAINS 99-97X OF 1,1,1-TRICH LOROETHANE... A OTHER MATERIALS. (BROWNING. TOX t METAB INDUS SOLV 1965 259) Stabilising agents which way be present in small amounts include: glycol dies tens, ketones, nitriles, dialkyl sulfoxides, dialkyl sulfides, dialkyl sulfites, tetraethyl lead, nitroaliphatic hydrocarbons, 2-methyl-3-butyn-2-ol, tert-butyl alcohol, 1,9-dioxane, dioxolane, sec-butyl alcohol, and monohydric acetylenic alcohols. (NIOSH; Criteria Document: 1.1.1-Trichloroethane p.ll (1976) DHEW Pub No 76-1893 Dow Chem Co, HQ, 2020 Dow Center, Midland, MI 98690 (517) 636-1000 [CAMPBELL. CHEMWEEK BUYER'S GUIDE 1989 566) Captree Chem Co, HQ, 995 Winding Rd, Old Bethpage, NY 11809 (516) 752-9808 (CAMPBELL. CHEMWEEK BUYER'S GUIDE 1989 566) Bentley Chem Corp, HQ, 190 North Canon Drive, Beverly Hills, CA 90210 (213) 272-9996 (CAMPBELL. CHEMWEEK BUYER'S GUIDE 1989 5663 Diamond Shamrock Corp, HQ, 1100 Superior Ave, Cleveland, OH 99119 (216) 699-9332 [CAMPBELL. CHEMWEEK BUYER'S GUIDE 1989 566) Pai--chem Prod Inc Specialty Chem, HQ, PO Box 92292, Houston, TX 77092 (713) 780-8169 [CAMPBELL. CHEMWEEK BUYER'S GUIDE 1989 566) Schumacher JC, Co, HQ, 580 Airport Rd, Oceanside, CA 92059 (619) 933-1663 [CAMPBELL. CHEMWEEK BUYER'S GUIDE 1989 566) DOW CHEM U.S.A., FREEPORT, TX 77591; PLAQUEMINE, TX 70769 [SRI) PPG INDUST, INC, CHEMS GROUP, INDUST CHEM DIV CHARLES, LA 70601 [SRI] VULCAN MATERIALS CO, VULCAN CHEMS, DIV, SL 030305 ' '\ O; ;O i m m n 000 PAGI 1,1,1-TRICHLOROETHANE MAJOR USES MAJOR USES MAJOR USES MAJOR USES MAJOR USES MAJOR USES MAJOR USES MAJOR USES MAJOR USES MAJOR USES MAJOR USES MAJOR USES MAJOR USES MAJOR USES CONSUMPTION PATTERNS CONSUMPTION PATTERNS CONSUMPTION PATTERNS U.S. PRODUCTION U.S. PRODUCTION U.S. PRODUCTION U.S. PRODUCTION U.S. PRODUCTION U.S. PRODUCTION GEISMAR, LA 70734 [SRI] SOLVENT FOR NATURAL 4 SYNTHETIC RESINS, OILS, WAXES, TAR 4 ALKALOIDS [BROWNING. TOX 4 METAB INDUS SOLV 1965 254) DRY CLEANING AGENT [HAMILTON. INDUS TOX 3RD ED 1974 285] CLEANING PLASTIC MOLDS EHERCK INDEX 9TH ED 1976 1237] ...FORMERLY USED WITH ETHYLENE GAS FOR DEGREENING CITRUS FRUITS 4 POSTHARVEST FUMIGATION OF STRAWBERRIES. ... REGISTERED AGRICULTURAL USES CANCELED. [FARM CHEM HDBK 1981, p. C-345] CLEANING SOLVENT, ESP FOR ELECTRICAL MACHINERY 4 PLASTICS [SRI] SPOTTING FLUID IN TEXTILE PROCESSING [SRI] COMPONENT OF AEROSOL FORMULATIONS [SRI] CHEM INT FOR ORG CHEMS-EG, VINYLIDENE CHLORIDE [SRI] SOLVENT FOR ADHESIVES 4 COATINGS [SRI] COOLANT 4 LUBRICANT IN METAL CUTTING OILS [SR I] EXTRACTION SOLVENT [SRI] COMPONENT OF INKS 4 DRAIN CLEANERS [SRI] SOLVENT FOR PHOTORESIST POLYMERS ISRII SOLVENT IN TEXTILE DYEING [SRI] Cold cleaning, 40XJ vapor degreasing, 22X! adhesives, 12X; aerosols, 10X, exports, 5X; electronics, 6X! coatings, IX! miscellaneous, 4X. CKAVALER. CHEM MARKET REPORTER 1984 66] The demand in 1982 uas 588x10+6 lb, in 1983, 606x10+6 lb and 680x10+6 lb is projected for 1987. [KAVALER. CHEM MARKET REPORTER 1984 661 CLEANING SOLVENT, 70X1 AEROSOLS, 5X! CHEM INT, 3X*, OTHER, 22X (1980, EST) [SRI] (1973) 548,394,000 lb [NIOSH. Criteria Document: 1,1,1-Trichloroethane 1976 DHEW Pub No 76-184] (1966) 242,943,000 lb [NIOSH. Criteria Document! 1,1,1-Trichloroethene 1976 DHEW Pub No 76-184] (1981) 613,993 (1,000 unit lb) [USITC. Syn Organic Chem US Prod 4 Sales 1982. USITC Pub 12921 (1978) 2.92X10+11 G [SRI] (1983) 2.26X10+11 G [SRI] The growth rate from 1973-1982 uas 3.2X per yr 4 a growth rate of 3 to 5X per yr is predicted through 1987. [KAVALER. CHEM MARKET REPORTER 1984 66] SL 030306 m i !m m ii 0000 1,111-TRICH LOROETHANE PASE U.S. PRODUCTION U.S. IMPORTS U.S. IMPORTS U.S. EXPORTS U.S. EXPORTS COLOR/FORM ODOR BOILING POINT MELTING POINT HOLECULAR WEIGHT CORROSIVITY DENSITY/SPECIFIC GRAVITY HEAT OF COMBUSTION HEAT OF VAPORIZATION OCTANOL/WATER PARTITION COEFFICIENT SOLUBILITIES SOLUBILITIES SOLUBILITIES SOLUBILITIES SPECTRAL PROPERTIES SPECTRAL PROPERTIES SURFACE TENSION VAPOR DENSITY VAPOR PRESSURE RELATIVE EVAPORATION RATE Annual production capacity = 1.3x10+8 lb [SRI. Dir of Chem Produceri, USA 949, 1982] (1977) ND [SRI] (1982) ND [SRI] (1978) 1.80X10+10 G [SRI] (1983) 2.58X10+10 G [SRI] COLORLESS LIQUID [PATTY. INDUS HYG & TOX 3RD ED VOL2A,2B,2C 1981-82 3503] CHLOROFORM-LIKE ODOR; SWEETISH [CHRIS. HAZARD CHEM DATA MANUAL 2 1978) 74.1 DEG C AT 760 MM HG [WEAST. HDBK CHEM A PHYS 60TH ED 1979, p. C-294) -30.41 DEG C [WEAST. HDBK CHEM A PHYS 60TH ED 1979, p. C-294) 133.42 [MERCK INDEX 9TH ED 1976 1237] Readily corrodes aluminum and aluminum alloys. tITI. TOX A HAZARD INDUS CHEM SAFETY MANUAL 1982 536) 1.3376 AT 20 DEG C/4 DEG C [MERCK INDEX 9TH ED 1976 1237] 4700 BTU/LB= 2600 CAL/G= 110X10+5 JOULES/KG [CHRIS. HAZARD CHEM DATA MANUAL 2 1978] 8012.7 gcal/gmole [Weast, HdbK Chem A Phys 64th ed p.C691 (1984)] 2.49 [CHRIS. HAZARD CHEM DATA MANUAL 2 1978] INSOLUBLE IN WATER [MERCK INDEX 9TH ED 1976 12371 SOL IN ACETONE, BENZENE, METHANOL, CARBON TETRACHLORIDE, ETHER [MERCK INDEX 9TH ED 1976 1237) MISCIBLE WITH ALCOHOL, ETHER; SOL IN CHLOROFORM [WEAST. HDBK CHEM A PHYS 60TH ED 1979, p. C-294] In water: 4,400 mg/1 at 20 deg C. [VERSCHUEREN. HDBK ENVIRON DATA ORG CHEM 1983 606) SADTLER REF NUMBER: 19461 (IR, PRISM) [WEAST. HDBK CHEM A PHYS 60TH ED 1979, p. C-294] INDEX OF REFRACTION: 1.4379 AT 20 DEG C/D [WEAST. HDBK CHEM A PHYS 60TH ED 1979, p. C-294] 25.4 DYNES/CM= 0.0254 NEWTONS/M AT 20 DEG C [CHRIS. HAZARD CHEM DATA MANUAL 2 1978) 4.63, relative (Air=l) [VERSCHUEREN. HDBK ENVIRON DATA ORG CHEM 1983 1129) 127 MM HG AT 25 DEG C [SUNSHINE. HDBK ANALY TOX 1969 663) Evaporation Rate (Butyl Acetate=l): 12.8 [NIOSH OSHA. OCCUPAT HEALTH GUIDE CHEM HAZARDS 1981] SL 030307 J 000 PAGl 1,1,1-TRICH LOROETHANE o oRELATIVE EVAPORATION RATE 1 (CC14 =1). [General Electric Co! Material o OTHER CHEMICAL/PHYSICAL Safety Data Sheet >331 (1983)1 PERCENT IN SATURATED AIR: 16.7 AT 25 DEG CJ PROPERTIES EQUIVALENCIES: 1 MG/KG= 183 PPM A 1 PPM= 5.96 MG/L AT 25 DEG C, 760 TORR [PATTY. INDUS HYG A TOX 3RD ED VOL2A,2B,2C 1981-82 J 35031 OTHER CHEMICAL/PHYSICAL PROPERTIES OTHER CHEMICAL/PHYSICAL 100 BTU= 58 CAL/G= 2.4X10+5 JOULES/KG [CHRIS. HAZARD CHEM DATA MANUAL 2 19783 Liquid-water interfacial tension: (est) 45 o PROPERTIES dynes/cm = 0.045 N/m at 20 deg C. [CHRIS. HAZARD CHEM DATA MANUAL 2 19781 C oOTHER CHEMICAL/PHYSICAL PROPERTIES Ratio of specific heats of vapor (gas): 1.104. [CHRIS. HAZARD CHEM DATA MANUAL 2 19781 OTHER CHEHICAL/PHYSICAL Sat concn in air 726 g/cu m 3 20 deg C> O PROPERTIES 1,088 g/cu m 3 30 deg C. [VERSCHUEREN. KDBK ENVIRON DATA ORG CHEM 1983 606) o FIRE POTENTIAL IT BURNS ONLY IN EXCESS OF OXYGEN OR IN AIR IF A STRONG SOURCE OF IGNITION IS PRESENT. o FIRE POTENTIAL tACGIH. TLVS 4TH ED A SUPPL 1980 2691 NONFLAMMABLE [MERCK INDEX 9TH ED 1976 12371 0 FLAMMABLE LIMITS FLAMMABLE LIMITS IN AIR: 7X-16X [CHRIS. HAZARD CHEM DATA MANUAL 2 19781 a FLAMMABLE LIMITS LIMITS OF FLAMMABILITY OF VAPORS OF INHIBITED 1,1,1-TRICHLOROETHANE HAVE BEEN 0 FOUND TO BE 10 TO 15.SY. IN AIR NITH HOT NIRE IGNITION. A CONSIDERABLE AMT OF ENERGY IS 0 REQUIRED FOR IGNITION. [PATTY. INDUS HYG A TOX 3RD ED VOL2A,2B,2C 1981-82 3503) 0 AUTOIGNITION TEMPERATURE 932 DEG F [CHRIS. HAZARD CHEM DATA MANUAL 2 19781 O FIRE FIGHTING PROCEDURES FIREFIGHTING METHODS: DRY CHEMICAL, FOAM, OR CARBON DIOXIDE [CHRIS. HAZARD CHEM DATA MANUAL 2 19781 INTENSITY OF HEAT 2.9 niin/inin (est) [CHRIS. HAZARD CHEM DATA MANUAL 2 19781 o TOXIC COMBUSTION PRODUCTS Toxic and irritating gases are generated. [CHRIS. HAZARD CHEM DATA MANUAL 2 1978] EXPLOSIVE LIMITS AND SIDES OF 5,000 PSI AUTOCLAVE...BULGED BY <J POTENTIAL EXPLOSIVE REACTION BETWEEN OXYGEN AND 1,1i1-TRICHLOROETHANE WHEN PRESSURIZED MIXT WAS BROUGHT UP TO 100 DEG C & 790 PSI A ALLOWED TO STAND FOR 3 HR. [NFPA. FIRE PROTECT GUIDE HAZARD MATLS 1978, p. w 491M-2941 EXPLOSIVE LIMITS AND SEVERAL HALOGENATED SOLVENTS REACTED POTENTIAL EXPLOSIVELY WITH LIQ OXYGEN WHEN IGNITED WITH A HIGH ENERGY SOURCE: 1,1,1-TRICHLOROETHANE... [NFPA. FIRE PROTECT GUIDE HAZARD MATLS 1978, p. 491M-2951 EXPLOSIVE LIMITS AND Exploded after heating under oxygen (gas) at SL 030308 ii 0000 m 1,1,1-TRICHLOROHTHANE PAGI POTENTIAL 54 bar and 100 deg C for 3 hr. CBretherick L! Handbk Reac Chem Has p.906 (1975)] EXPLOSIVE LIMITS AND Mixture of liquid oxygen with... POTENTIAL 1,1,1-trichloroethane... exploded violently when initiated with a blasting cap. m tBRETHERICK. HDBK REAC CHEM HAZARD 2ND ED 1979 361] REACTIVITIES Reacts slowly with water, releasing INCOMPATIBILITIES hydrochloric acid. [CHRIS. HAZARD CHEM DATA m MANUAL 2 1978] REACTIVITIES Although apparently stable on contact, INCOMPATIBILITIES mixtures with potassium (or its alloys)... are shock-sensitive and may explode with m great violence on light impact. CBRETHERICK. HDBK REAC CHEM HAZARD 2ND ED 1979 361) REACTIVITIES Violent decomp, with evolution of hydrogen INCOMPATIBILITIES chloride, may occur when /it/ comes into contact with aluminium or its alloys with magnesium. CBRETHERICK. HDBK REAC CHEM HAZARD 2ND ED 1979 361] REACTIVITIES Reacts with caustic soda or caustic potash INCOMPATIBILITIES to form flammable or explosive material. Attacks natural rubber. [General Electric Coi Material Safety Data Sheet #331 (1983)] m REACTIVITIES INCOMPATIBILITIES PIPE- SOLENOID-VALVE ASSEMBLY USED TO TRANSFER NAK /SODIUM POTASSIUM/...PURGED WITH NITROGEN, THEN FLUSHED WITH WATER. TRICHLOROETHANE, USED...TO REMOVE TRACES OF WATER, CONTACTED HIDDEN RESIDUE OF NAK /SODIUM POTASSIUM/ IN ONE VALVE AND EXPLOSION ENSUED. CNFPA. FIRE PROTECT GUIDE HAZARD MATLS 1978, p. 491M-394) REACTIVITIES Decomposes by reaction with finely divided INCOMPATIBILITIES white metals, such as aluminum, magnesium, or zinc. [General Electric Co) Material Safety Data Sheet #331 (1983)) DECOMPOSITION ...DECOMP TO LARGE AMT OF HYDROCHLORIDE TRACE AMT OF PHOSGENE AT 500 DEG. CRUMACK. POISINDEX 1975-PRESENT, p. MGT 4/EXP 8308] DECOMPOSITION Decomposes at high temp, upon contact with hot metal, or under UV radiation to produce m toxic and corrosive gases which include! dichloroacetylene and chlorine. [General Electric Co! Material Safety Data Sheet #331 m ODOR THRESHOLD (1983)} 100 ppm. [CHRIS. HAZARD CHEM DATA MANUAL 2 1978) CM)OR THRESHOLD 44 ppm CVERSCHUEREN. HDBK ENVIRON DATA ORG m SKIN, EYE AND RESPIRATORY CHEM 1983 606] Vapors cause a slight smarting of the eyes IRRITATIONS or respiratory system if present in high concn. The effect is temporary. [CHRIS. SL 030309 !! Q .O ;O o : > O 0 0 iI | i# 0000 1,1,1-TRICHLOROETHANE PAG] SKIN, EYE AND RESPIRATORY IRRITATIONS PROTECTIVE EQUIPMENT A CLOTHING PROTECTIVE EQUIPMENT A CLOTHING SHIPMENT METHODS AND REGULATIONS SHIPMENT METHODS AND REGULATIONS SHIPMENT METHODS AND REGULATIONS SHIPMENT METHODS AND REGULATIONS STORAGE CONDITIONS CLEANUP METHODS STABILITY/SHELF LIFE DOT EMERGENCY GUIDELINES HAZARD CHEM DATA MANUAL 2 1978] If the liquid is spilled on clothing and allowed to remain, may cause smarting and reddening of the skin. tCHRIS. HAZARD CHEM DATA MANUAL Z 1978] ORG VAPOR-ACID GAS CANISTER; SELF-CONTAINED BREATHING APPARATUS FOR EMERGENCIES; NEOPRENE OR POLYVINYL-ALCOHOL-TYPE GLOVES; CHEMICAL SAFETY 60GGLES A FACE SHIELD! NEOPRENE SAFETY SHOES (OR LEATHER SAFETY SHOES PLUS NEOPRENE FOOTWEAR); NEOPRENE OR POLYVINYL ALCOHOL SUIT OR APRONS FOR SPLASH PROTECTION. [CHRIS. HAZARD CHEM DATA MANUAL Z 1978] THE PERMEATION RATES OF SOLVENTS INCL 1,1,1-TRICHLOROETHANE THROUGH PROTECTIVE RUBBER GARMENT MATERIALS ARE LESS THAN 6.36 MIN/MIL, EXCEPT FOR UNWRINKLED TEFLON A VITON WHICH IS MORE THAN 720 4 82 TO ABOVE 144 MIN/MIL, RESPECTIVELY. [WEEKS RW JR, MCLEOD Mj; PERMEATION OF PROTECTIVE GARMENT MATERIALS BY LIQUID HALOGENATED ETHANES AND A POLYCHLORINATED BIPHENYL; ACS SYMP SER 149CISS CHEM HAZARD WORKPLACE! MEAS CONTROL) 235 (1981)1 SHIPPING REGULATIONS: REGULATED BY IATA. [SAX. DANGER PROPS INDUS MATER 4TH ED 1975 1186) SHIPPING REGULATIONS! DOT-ORM-A, LABEL! NONE. ENIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/8303] CONTAINERS: DRUMS, TANK CARS. [HAWLEY. CONDENSED CHEM DICTNRY 9TH ED 1977 877] Containers: resin lined. [NIOSH; Criteria Document: 1,1,1-Trichloroethane p.72 11976) DHEW Pub NIOSH 76-184] Use ambient storage temp and pressure-vacuum venting. [CHRIS. HAZARD CHEM DATA MANUAL 2 1978) 1. VENTILATE AREA OF SPILL OR LEAK. 2. COLLECT FOR RECLAMATION OR ABSORB IN VERMICULITE, DRY SAND, EARTH, OR A SIMILAR MATERIAL. [NIOSH OSHA. OCCUPAT HEALTH GUIDE CHEM HAZARDS 1981] Stable during transport. [CHRIS. HAZARD CHEM DATA MANUAL 2 19783 Health Hazards: Vapors may cause dizziness or suffocation. Exposure in an enclosed area may be very harmful. Contact may irritate or burn skin and eyes. Fire may produce irritating or poisonous gases. Runoff from SL 030310 m m m m m m m w m M 0000 1,111-TRICH LOROETHANE PAGI DOT EMERGENCY GUIDELINES DOT EMERGENCY GUIDELINES DOT EMERGENCY GUIDELINES DOT EMERGENCY GUIDELINES DOT EMERGENCY GUIDELINES POISONING POTENTIAL fire control or dilution water may cause pollution. /Trichloroethane/ EDOT. EMERGENCY RESPONSE GUIDEBOOK 1984, p. G-74J Fire or Explosion! Some of these materials may burn but none of them ignite readily. Most vapors are heavier than air. Container may explode in heat of fire. /Trichloroethane/ EDOT. EMERGENCY RESPONSE GUIDEBOOK 1984, p. G-74] Emergency Action! Keep unnecessary people away. Stay upwind; Keep out of low areas. Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing. Isolate for 1/2 mile In all directions if tank car or truck is involved in fire. Remove and isolate contaminated clothing at the site. If water pollution occurs, notify appropriate authorities. FOR EMERGENCY ASSISTANCE CALL CHEMTREC (800) 424-9300. /Trichloroethane/ EDOT. EMERGENCY RESPONSE GUIDEBOOK 1984, p. G-74) Fire! Small Fires! Dry chemical or C02, Large Fires! Water spray, fog or foam. Stay away from ends of tanks. Cool containers that are exposed to flames with water from the side until well after fire is out. /Trichloroethane/ [DOT. EMERGENCY RESPONSE GUIDEBOOK 1984, p. G-74) Spill or Leak: Stop leak If you can do it without risk. Shut off ignition sources; no flares, smoking or flames in hazard area. Small Liquid Spills! Take up with sand, earth or other noncombustible absorbent material. Large Spills: Dike far ahead of spill for later disposal. /Trichloroethane/ [DOT. EMERGENCY RESPONSE GUIDEBOOK 1984, p. G-74) First Aid: Move victim to fresh air; call emergency medical care. If not breathing, give artifical respiration. If breathing is difficult, give oxygen. Remove and isolate contaminated clothing and shoes at the site. In case f contact with material, immediately flush eyes with running water for at least 15 minutes. Wash skin with soap and water. Use first aid treatment according to the nature of the injury. /Trichloroethane/ [DOT. EMERGENCY RESPONSE GUIDEBOOK 1984, p. G-74) ...TOXIC EFFECTS OCCUR ONLY WITH CONCN OF MORE THAN 500 PPM. ...TWO REPORTED HUMAN SI- 030311 0000' 1,1,1-TRICH LOROETHANE PASI POISONING POTENTIAL ANTIDOTE AND EMERGENCY TREATMENT ANTIDOTE AND EMERGENCY TREATMENT ANTIDOTE AND EMERGENCY TREATMENT ANTIDOTE AND EMERGENCY TREATMENT ANTIDOTE AND EMERGENCY TREATMENT DEATHS FROM EXPOSURE TO HIGH CONCN IN UNVENTILATED DRUMS. EGOSSELIN. CTCP ATH ED 1976, p. II-I13) Est lethal dose for 150 lb man is 0.5 to 1 pint. [General Electric Co, Material Safety Data Sheet #331 (1983)) SEE TRICHLOROETHANE. GENERAL MGMNT: A) ESTABLISH RESPIRATION: CREATE ARTIFICIAL AIRHAY IF NECESSARY. CHECK ADEQUACY OF TIDAL VOL (N0RMAL= 10-15 CC/KG). /TRICHLOROETHANE/ [RUMACK. POISINDEX 1975-PRESENT, p. MGT A/EXP 83081 SEE TRICHLOROETHANE. PREVENTION OF ABSORPTION (ORAL INGESTION): A) EMESIS...UNLESS PT...COMATOSE, CONVULSING, OR...LOST GAG REFLEX. IF THESE CONTRAINDICATIONS...PRESENT, ENDOTRACHEAL INTUBATION SHOULD PRECEDE GASTRIC LAVAGE WITH LARGE BORE TUBE. B) ADMIN ACTIVATED CHARCOAL (ADULT: 60-100 G; CHILDREN: 30-60 G). C) ADMIN CATHARTIC. MAGNESIUM SULFATE (ADULT: 30 G, CHILDREN: 250 MG/KG). /TRICHLOROETHANE/ [RUMACK. POISINDEX 1975-PRESENT, p. MGT A/EXP 8308) SEE TRICHLOROETHANE. PREVENTION OF ABSORPTION (ORAL EXPOSURE): A) ...TREAT SEIZURES WITH IV DIAZEPAM (ADULT: UP TO 10 MG SLOWLY, REPEAT IF NECESSARY, CHILDREN: 0.1 TO 0.3 MG/KG SLOWLY). B) THERE IS NO SPECIFIC TREATMENT FOR TRICHLOROETHANE POISONING, SUPPORTIVE MEASURES SHOULD BE INSTITUTED PROMPTLY TO COMBAT EFFECTS OF CNS DEPRESSION, RESPIRATION SHOULD BE ASSISTED IF NECESSARY. C) MONITOR CARDIAC FUNCTION CLOSELY. D) OBTAIN BASELINE HEPATIC & KIDNEY FUNCTION TEST... /TRICHLOROETHANE/ [RUMACK. POISINDEX 1975-PRESENT, p. MGT A/EXP 8308) SEE TRICHLOROETHANE. INHALATION: A) REMOVE...TO FRESH AIR. B) MONITOR PT FOR RESP DISTRESS, IF COUGH OR DIFFICULTY IN BREATHING DEVELOPS, EVALUATE FOR RESP TRACT IRRITATION, BRONCHITIS, A PNEUMONIA. C) TREATMENT SHOULD INCL RECOMMENDATIONS LISTED IN ORAL EXPOSURE SECTION WHEN APPROPRIATE. /TRICHLOROETHANE/ [RUMACK. POISINDEX 1975-PRESENT, p. MGT A/EXP 6308) SEE TRICHLOROETHANE. EYE EXPOSURE: A) .../IRRIGATE/ COPIOUSLY WITH WATER FOR AT LEAST 15 MIN. B) OPHTHALMIC EXAM SHOULD BE PERFORMED IF IRRITATION OR PAIN PERSISTS AFTER 15 MIN OF IRRIGATION WITH WATER. /TRICHLOROETHANE/ [RUMACK. POISINDEX si- 030312 0000' 1,1,1-TRICHLOROETHANE PAS1 0 ANTIDOTE AND EMERGENCY TREATMENT MEDICAL SURVEILLANCE MEDICAL SURVEILLANCE HUMAN TOXICITY EXCERPTS HUMAN TOXICITY EXCERPTS HUMAN TOXICITY EXCERPTS HUMAN TOXICITY EXCERPTS HUMAN TOXICITY EXCERPTS HUMAN TOXICITY EXCERPTS SL 030313 1975-PRESENT, p. MGT 4/EXP 83083 SEE TRICHLOROETHANE. DERMAL EXPOSURE: A) ...WASH...WITH SOAP A WATER. B) PHYSICIAN SHOULD EXAM...AREA IF IRRITATION OR PAIN PERSISTS AFTER AREA IS WASHED. C) TREATMENT SHOULD INCL RECOMMENDATIONS LISTED IN ORAL EXPOSURE SECTION WHEN APPROPRIATE. /TRICHLOROETHANE/ tRUMACK. POISINDEX 1975-PRESENT, p. MGT 4/EXP 8308] Preplacement and periodic medical exam of exposed personnel with consideration of the cardiovascular system, liver, CNS functions, and skin. [Gen Elec Corp; Material Safety Data Sheet p.311 (1983)] Physical exam of exposed personnel annually, including studies of liver and kidney function. EITI. TOX A HAZARD INDUS CHEM SAFETY MANUAL 1982 5363 DEATH IS USUALLY DUE TO RESP ARREST OR PERIPHERAL VASCULAR COLLAPSE. [GRANT. TOX OF THE EYE 1974 1863 MEN EXPOSED 3 900 TO 1000 PPM EXPERIENCED TRANSIENT MILD IRRITATION A MINIMAL IMPAIRMENT OF COORDINATION. ABOVE 1700...THIS MAGNITUDE MAY INDUCE HEADACHE A LASSITUDE... CACGIH. TLVS 3RD ED A SUPPL 1971-1979 1613 PROLONGED OR REPEATED CONTACT WITH SKIN RESULTS IN TRANSIENT ERYTHEMA...DEFATTING ACTION... CENCYC OCCUPAT HEALTH A SAFETY 1971 14323 SEE TRICHLOROETHANE. CLINICAL EFFECTS: NEUROLOGIC: SYMPTOMS OF ACUTE OVERDOSASE INCL DIZZINESS, FAINTING...A COMA. ... GI: NAUSEA A VOMITING... CARDIOVASCULAR: ...HYPOTENSION... CARDIAC ARRHYTHMIAS MAY RESULT FROM MYOCARDIAL SENSITIZATION. ... HEPATIC: MAY CAUSE TRANSIENT INCR IN LIVER ENZYMES. /TRICHLOROETHANE/ tRUMACK. POISINDEX 1975-PRESENT, p. MGT 4 EXP/83083 SEE TRICHLOROETHANE. CLINICAL EFFECTS: OPHTHALMIC: CONTACT WITH THE EYES MILL RESULT IN CHEMOSIS A HYPEREMIA. ORAL: BURNS OF THE ESOPHAGUS HAVE BEEN NOTED AFTER LARGE INGESTIONS. DERMAL: SKIN VESICATIONS MAY OCCUR WITH PROLONGED CONTACT. /TRICHLOROETHANE/ tRUMACK. POISINDEX 1975-PRESENT, p. MGT 4/EXP 83033 1,1,1-TRICHLOROETHANE (TCE) WAS INDICATED IN ACCIDENTAL DEATH OF A WOMAN CLEANING UP A PAINT SPILL IN POORLY VENTILATED ROOM. TCE IN BLOOD AT CONCN ABOVE 1.0 TO 1.5 MG/100 ML 0000 111,1-TRICHLOROETHANE PAGI HUMAN TOXICITY EXCERPTS HUMAN TOXICITY EXCERPTS HUMAN TOXICITY EXCERPTS HUMAN TOXICITY EXCERPTS HUMAN TOXICITY EXCERPTS CONSISTENT WITH DEATH. [CAPLAN YH ET ALi 1,1,1-TRICHLOROETHANE: REPORT OF A FATAL INTOXICATION; CLIN TOXICOL 9(1) 69 (1976)] EXCESSIVE ABSORPTION THROUGH LUNGS OR GI TRACT PRODUCES CNS DEPRESSION PROPORTIONAL TO AMT ABSORBED. MILD LIVER A KIDNEY DYSFUNCTION MAY OCCUR TRANSIENTLY FOLLOWING RECOVERY FROM CNS DEPRESSION. [STEWART RD; METHYL CHLOROFORM INTOXICATION: DIAGNOSIS AND TREATMENT; J AMER MED ASS 215(11) 1789 (1971)] THIS REPORT DESCRIBES A CASE OF NEAR-FATAL INTOXICATION FOLLOWING ACCIDENTAL EXPOSURE OF A CHILD TO 1,1,1-TRICHLOROETHANE. EXPOSURE TO HIGH LEVELS OF THIS SOLVENT WHICH IS WIDELY USED IN INDUST A DOMESTIC PREPN CAN RESULT IN RESP DEPRESSION A/OR DYSRHYTHMIAS. [GERACE RV; NEAR-FATAL INTOXICATION BY 1,1,1-TRICHLOROETHANE; ANN EMERG MED 10(10) 533 (1981)] THE EFFECT OF THE SOLVENT METHYLCHLOROFORM ON PSYCHOPHYSIOLOGICAL FUNCTIONS, SUCH AS REACTION TIME, PERCEPTUAL SPEED & MANUAL DEXTERITY, WAS STUDIED IN 12 HEALTHY, MALE SUBJECTS. EACH SUBJECT WAS REPEATEDLY TESTED DURING EXPOSURE TO 250 PPM, 350 PPM, 950 PPM A 550 PPM OF METHYCHLOROFORM IN INSPIRATORY AIR A UNDER CONTROL CONDITIONS WITH EXPOSURE TO PURE AIR. A LINEAR RELATIONSHIP WAS NOTED BETWEEN THE CONCN IN ALVEOLAR AIR A ARTERIAL BLOOD. SUBJECT REACTION TIME, PERCEPTUAL SPEED A MANUAL DEXTERITY WERE ALL IMPAIRED DURING EXPOSURE. ANALYSES OF THE RESULTS STRONGLY SUGGEST THAT PSYCHOPHYSIOLOGICAL FUNCTIONS IN HUMANS ARE UNFAVORABLY AFFECTED BY AN EXPOSURE TO AN AVG CONCN OF 350 PPM. (GAMBERALE F, HULTENGREN M; METHYLCHLOROFORM EXPOSURE: II. PSYCHOPHYSIOLOGICAL FUNCTIONS; WORK-ENVIRON-HEALTH 10(2) 82 (1973)) SERIES OF ACUTE A CHRONIC VAPOR EXPOSURES TO 500 PPM BY 11 MALE VOLUNTEERS 31-62 YR OF AGE WERE CONDUCTED TO ESTABLISH NO EFFECT CONCN. [STEWART RD; EXPERIMENTAL HUMAN EXPOSURE TO METHYL CHLOROFORM VAPOR; ARCH ENVIRON HEALTH 19(9) 967 (1969)] From /the available/ data..., it can be estimated that a single exposure to concn of methyl chloroform less than 5,000 ppm is probably not ... life threatening to humans, while higher concn may produce narcosis and possibly death. (USEPA! Health Assessment Document: 1,1,1-Trichloroethane p.5-96 SL 030314 000flBT7 m 1,1>1-TRICH LOROETHANE PAGWI2 (1982) EPA-600/8-82-003) HUMAN TOXICITY EXCERPTS A summary of the estimated dose-response relationships for acute effects of single short term exposures 1st >5000 ppm: onset of narcosis, possible life threatening; 2,650-1900 ppm: 1ight-headedness> irritation of the throat; 1000 ppm: disturbance of equilibrium; 500-350 ppm: slight changes in perception! obvious odor; 100 ppm! apparent odor threshold... these approximations are crude estimates and contain several areas of uncertainty. tUSEPA; Healh Assessment Document: 1ilt1-Trichloroethane p.5-69 to # 5-50 (1982) EPA-600/8-82-003) HUMAN TOXICITY EXCERPTS Neurophysiological parameters were studied in 22 women exposed for 6.5 yr to methyl chloroform vapors ranging between 110 to 990 m ppm. As compared to 7 unexposed womeni no differences were found in clinical symptoms or measures of nerve conduction velocity and psychometric function. IMaroni M et al; m Scand J Work Environ Health 3: 16-22 (1977) as cited in USEPA; Health Assessment Document: 1>1(1-Trichloroethane p.5-9 A 5-53 (1982) EPA-600/8-82-003) ** HUMAN TOXICITY EXCERPTS Four groups of workers (total no=196) exposed for at least 5 yr to average concn of 6, 25i 28 and 53 ppm methylchloroform were evaluated for adverse effects. Routine laboratory examsi including peripheral hemogramsi blood specific gravity and urinalysis! plus sense of vibration tests were used. No consistent dose-related # adverse effects were observed. (Seki Y et al; Int Arch Arbeitsmed 36: 39-69 (1975) as cited in USEPA; Health Assessment Document: 1flil-Trichloroethane p.5-9 A 5-53 (1982) E PA-60 0/8-82-003) HUMAN TOXICITY EXCERPTS The /available/ studies for workers occupationally exposed to methyl chloroform... /indicate that/ it is & reasonable to assume that 53 ppm is a NOEL /for long term exposure/... (USEPA; Health Assessment Document: 1,1,1-Trichloroethane p.5-52 A 5-53 (1982) EPA-600/8-82-003) NON-HUMAN TOXICITY ...REPEATED EXPOSURES...FOR 7 HR/DAYi 5 EXCERPTS DAYS/WK FOR 1 TO 3 MO. AT 10,000 PPM RATS...STAGGERING GAIT A WEAKNESS IN 10 MIN. BY 3 HR...IRREGULAR RESPIRATION A SEMICONSCIOUSNESS. [PATTY. INDUS HYG A TOX 3RD ED VOL2A,2B,2C 1961-82 35063 NON-HUMAN TOXICITY IV DOSE OF 8.6 MILLIMOLE/KG TO DOGS WAS SL 030315 # 001 EXCERPTS NON-HUMAN TOXICITY EXCERPTS NON-HUMAN TOXICITY EXCERPTS NON-HUMAN TOXICITY EXCERPTS NON-HUMAN TOXICITY EXCERPTS NON-HUMAN TOXICITY EXCERPTS SL 030316 1,1,1-TRICH LOROETHANE PAI 3 MEDIAN EFFECTIVE DOSE FOR INCR SERUM GLUTAMIC-PYRUVIC TRANSAMINASE ACTIVITY INDICATING LIVER DYSFUNCTION CONSISTING OF CENTRILOBULAR NECROSIS i MODERATE NEUTROPHILIC INFILTRATIONS IN SINUSOIDS A PORTAL AREAS. [KLAASSEN CD, PLAA GLi RELATIVE EFFECTS OF VARIOUS CHLORINATED HYDROCARBONS ON LIVER AND KIDNEY FUNCTION IN DOGS! TOXICOL APPL PHARMACOL 10: 119 (1967)1 ONLY MILD HEPATIC DYSFUNCTION WAS OBSERVED WHEN 1i1,1-TRICHLOROETHANE HAS ADMIN IP TO MICE. (KLAASSEN CD, PLAA GL; RELATIVE EFFECTS OF VARIOUS CHLORINATED HYDROCARBONS ON LIVER AND KIDNEY FUNCTION IN MICE! TOXICOL APPL PHARMACOL 9(1) 139 (1966)1 RATS GIVEN 1500 t 750 MG/KG/DAY ORALLY FROM 7-117 WK OF AGE DEVELOPED NASAL DISCHARGE, WHEEZING, URINE STAINING ON ABDOMINAL FUR, A HUNCHED APPEARANCE. TUMORS OBSERVED WERE NOT ATTRIBUTED TO 1,1,1-TRICHLOROETHANE. (BIOASSAY OF 1,1,1-TRICHLOROETHANE FOR POSSIBLE CARCINOGENICITY; CARCINOG TECH REP SER- NATL CANCER INST (US) (ISS NCI-CG-TR-3) 70 (1977)1 ACUTE EXPOSURE OF ANESTHETIZED DOGS TO TCE RESULTED IN DOSE-DEPENDENT, BIPHASIC DECLINE IN ARTERIAL PRESSURE & CARDIOVASCULAR DEPRESSION. (HERD PA ET AL; CARDIOVASCULAR EFFECTS OF 1,1,1-TRICHLOROETHANE; ARCH ENVIRON HEALTH 8(9) 27 (1979)1 AT BLOOD LEVELS OF METHYLCHLOROFORM ABOVE 75 PPM A SO- CALLED POSITIONAL NYSTAGMUS, INDICATING CENTRAL VESTIBULO-OCULOMOTOR DISTURBANCES. (LARSBY B ET AL! EXPOSURE OF RABBITS TO METHYLCHLOROFORM: VESTIBULAR DISTURBANCE CORRELATED TO BLOOD AND CEREBROSPINAL FLUID LEVELS; INT ARCH OCCUP ENVIRON HEALTH 91(1) 7 (1978)1 RATS, GUINEA PIGS, SQUIRREL MONKEYS, RABBITS t DOGS HERE CONTINUOUSLY EXPOSED BY INHALATION FOR 90 DAYS OR FOR 8 HR, 5 DAYSXWK FOR 6 WK. OVER PERIOD OF ALMOST 9 YR NO SYMPTOMS OF TOXICITY WERE SEEN IN ANY SPECIES i 1,1,1-TRICH LOROETHANE DID NOT SIGNIFICANTLY AFFECT BLOOD SERUM UREA NITROGEN LEVELS. (PRENDERGAST JA ET AL; EFFECTS ON EXPERIMENTAL ANIMAL OF LONG-TERM INHALATION OF TRICHLORETHYLENE, CARBON TETRACHLORIDE, 1,1,1-TRICHLOROETHANE, DICHLORODIFLUOROMETHANE, AND 1,1-OICHLOROETHYLENE; TOXICOL APPL PHARMACOL 10(2) 270 (1967)1 w a w w a u # # o Q 13 OOi PAI 4 1,1.l-TRICHLOROETHANE NON-HUMAN TOXICITY EXCERPTS NON-HUMAN TOXICITY EXCERPTS NON-HUMAN TOXICITY EXCERPTS NON-HUMAN TOXICITY EXCERPTS NON-HUMAN TOXICITY EXCERPTS SL 030317 1.1.1-TETRACHLOROETHANE SHOWED MUTAGENIC ACTIVITIES WHEN TESTED BY SALMONSUA/MICROSOME TEST. THE BASC TEST ON DROSOPHILA, S THE MICRONUCLEUS TEST ON MOUSE BONE MARROW. EGOCKE E ET AL! MUTAGENICITY OF COSMETICS INGREDIENTS LICENSED BY THE EUROPEAN COMMUNITIES; MUTAT RES 90(2) 91 (1981)3 1.1.1-TRICHLOROETHANE WAS APPLIED TO SKIN OF GUINEA PIGS & BIOPSIES TAKEN AT DIFFERENT TIMES OF EXPOSURE. KARYOPYKNOSIS & KARYOLYSIS INDUCED. IT ALSO PRODUCED JUNCTIONAL SEPARATION t PSEUDOEOSINOPHILIC INFILTRATION. CKRONEVI T ET ALi SKIN PATHOLOGY FOLLOWING EPICUTANEOUS EXPOSURE TO SEVEN ORGANIC SOLVENTS; INT J TISSUE REACT 3(1) 21 (198DJ INTERMITTENT INHALATION EXPOSURE FOR 5 DAYS, FOR 6 HR/DAY TO 1,1,l-TRICHLOROETHANE OR IN COMBINATION WITH TRICHLOROETHYLENE CAUSED NO OBSERVABLE BEHAVIORAL EFFECTS IN RATS. CSAVOLAINEN Hi PHARMACOKINETICS, PHARMACODYNAMICS AND ASPECTS OF NEUROTOXIC EFFECTS OF FOUR INHALED ALIPHATIC CHLOROHYDROCARBON SOLVENTS AS RELEVANT IN MAN; EUR J DRUG METAB PHARMACOKINET 6(2) 85 (1981)] A MULTIGENERATION REPRODUCTION STUDY WAS MODIFIED TO INCL SCREENING FOR DOMINANT LETHAL AND TERATOGENIC EFFECTS OF 1,1,l-TRICHLOROETHANE IN DRINKING WATER SOLN. MALE t FEMALE ICR SWISS MICE RECEIVED 1,1,l-TRICHLOROETHANE AT CONCN OF 0, 0.58, 1.75, OR 5.83 MG/ML. THESE CONCN WERE DESIGNED TO YIELD DAILY DOSES OF 0, 100, 300, OR 1,000 MG/KG. NO TASTE AVERSION WAS EVIDENT & THERE APPEARED TO BE NO DOSE-DEPENDENT EFFECTS ON FERTILITY, GESTATION, VIABILITY OR LACTATION INDICES. PUP SURVIVAL t WT SAIN WERE NOT ADVERSELY AFFECTED. 1,1,l-TRICHLOROETHANE FAILED TO PRODUCE SIGNIFICANT DOMINANT LETHAL MUTATIONS OR TERATA IN EITHER OF THE 2 GENERATIONS TESTED. [LANE RW ET ALi EFFECTS OF 1,2-DICHLOROETHANE AND 1,1,l-TRICHLOROETHANE IN DRINKING WATER ON REPRODUCTION AND DEVELOPMENT IN MICE; TOXICOL APPL PHARMACOL 63(3) 409 (1982)1 CF-1 mice were continuously exposed to 0, 250 or 1,000 ppm by inhalation for up to 14 wk. At 1,000 ppm, moderate liver damage was indicated by elevated triglycerides, to OGOOtoP* to 1,1,1-TRICH LOROETHANE PAG^^5 cytoplasmic alterations, and necrosis of to hepatocytes. (McNutt NS et ali Lab Invest 32: 642-654 <1975)1 NON-HUMAN TOXICITY Long-Evans rats were exposed by inhalation EXCERPTS to to 100 + or - 200 ppm methyl chloroform 6 hrs/day, 5 days/wk, in one of four regimens: (I) two wk prior to mating through day 20 of gestation, (2) two wk prior to mating only, (3) throughout gestation only, (4) controls to which were exposed to filtered air before and during pregnancy. Total fatal body weight and male fetal body weight were depressed in litters exposed during to pregnancy. Delayed ossification was more frequent in fetuses exposed before and during pregnancy and a delay in kidney development was observed in fetuses from all to exposed groups. No treatment related behavioral effects were observed, nor were there significant signs of maternal toxicity. [York et all J Toxicol Environ to Health (in press) (1981) as cited in USEPAi Health Assessment Document: 1,1,1-Trichlorpethane p.5-34 to 5-35 (1982) E PA-6 00/8-82-00 31 to NON-HUMAN TOXICITY Methyl chloroform injected into air space at EXCERPTS 2, 3, and 6 days of incubation at 50 or 100 mg/egg. Malformations observed included absence of eyes, beak deformations, to exoencephaly, brain hemorrhages, anemia, edema, musculo-skeletal defects of lower extremities. EElovaara et ali Toxicology 12: 111 (1979) as cited in USEPAi Health to Assessment Document: 1,1,1-Trichloroethane p.5-35 (1982) EP-600/8-82-003) NON-HUMAN TOXICITY Cell transformation tests using Fischer 344 EXCERPTS to rat embryo cultures exposed to 9.9x10+1 or 9.9x10+2 uM for 48 hr were positive. Cells from foci of cultures treated with lower dose when injected sc into 8 newborn Fischer to 344 rats produced local fibrosarcomas in 100X. Cells from control (acetone-treated) cultures did not induce fibrosarcomas. [Price PJ et ali In Vitro 14: 290-293 (1978) as cited in USEPAi Health Assessment to Document:i,1,1-Trichloroethane p.7-16 to 7-17 (1982) EPA-600/8-82-003) NON-HUMAN TOXICITY Both sexes of Osborne-Mendel rats and 86C3F1 EXCERPTS to mice were exposed by gavage 5 days/wk for 78 wk. Dose levels were: rats (750 S 1,500 mg/kg), mice (2,807 t 5,615 mg/kg). High mortality observed. No dose-related SL 030318 to ooo a o 1,1,1-TRICHLOROETHANE PAI 6 Increased Incidence of tumors. [NCI! o Bioassay of 1,1,1-trichloroethane p.70 (1977) NCI-CG-TR-3 as cited in USEPA; Health Assessment Document: 1>1>1-Trichloroethane p,7-23 (1982) EPA-600/8-82-0033 o NON-HUMAN TOXICITY Study of male and female rats exposed by EXCERPTS inhalation 6 hr/day 5 days/wk for 52 wk to 875 ppm or 1750 ppm. No statistically significant increased incidence of tumors o was observed. tRampy LN et al; Proc Int Cong Toxicol (Toronto) p.27 (1977) as cited in USEPA; Health Assessment Document: 1>1>1-Trichloroethane p.5-90 (1982) EPA-6 00/8-82-00 3] NON-HUMAN TOXICITY Moderately pronounced venous hyperemia of EXCERPTS the lungs t emphysematous enlargement of individual groups of alveoli> and swelling Q of the bronchial epithelium was found in 5 rats exposed 9 hr/day, for 50 days at 73 ppm. After 120 days of exposure> the emphysematous condition was much more U pronounced. Intraalveolar walls were thin and some had broken down. Vascular walls were thickened and swollen> and around many of them were accumulations of lymphoid and histiocyte cell elements and isolated plasma cells. The mucous membrane of the bronchii was swollen* and small amt of mucous and detached epithelial cells in the lumen. Hyperplastic peribronchial lymphatic lymph nodules were found. ITsapko VG, Rappoport MBS Farmakol Toksikol 7: 199-51 (1972) as cited in NIOSH; Criteria Document: Q 1li1-Trichloroethane (reprint) p,93 (1979) DHEW Pub. NIOSH 79-189] HUMAN TOXICITY VALUES IRRITANT DOSE HUMAN OCULAR 950 PPM/8 HR. (NIOSH. RTECS ONLINE FILE, CURRENT FILE, p. & 83/8303) HUMAN TOXICITY VALUES LCLO HUMAN INHALATION 27 G/CU M/10 MIN. (NIOSH. RTECS ONLINE FILE, CURRENT FILE, p. O HUMAN TOXICITY VALUES 83/83031 TOLO HUMAN ORAL 670 MG/KG; TOXIC EFFECT: GASTROINTESTINAL TRACT EFFECTS. (NIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/83031 HUMAN TOXICITY VALUES TCLO HUMAN INHALATION 920 PPM/70 MIN; TOXIC EFFECTS: BEHAVIORAL t EYE EFFECTS. [NIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 63/83031 NON-HUMAN TOXICITY VALUES LD50 RATS ORAL 10300 MG/KG (NIOSH. RTECS ONLINE FILE, CURRENT FILE, p. c> 83/8303] NON-HUMAN TOXICITY VALUES LD50 RATS INTRAPERITONEAL 5100 MG/KG [NIOSH. RTECS ONLINE FILE, CURRENT FILE, p. SL 030319 i !J : -j 1 :^ , \ |$ :a :a j j I & ,9 # # 0000 1,1,1-TRICH LOROETHANE PAGI NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES 83/8303] LD50 DOGS ORAL 750 MG/KG [NIOSH, RTECS ONLINE FILE, CURRENT FILE, p. 83/8303] LD50 DOGS INTRAPERITONEAL 3100 MG/KG [NIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/8303] LCLO MICE INHALATION 11000 PPM/2 HR [NIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/8303] LD50 MICE INTRAPERITONEAL 4700 MG/KG [NIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/8303] LDLO DOGS INTRAVENOUS 95 MG/KG [NIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/8303] LDLO RABBITS SUBCUTANEOUS 500 MG/KG [NIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/8303] IRRITANT DOSE RABBITS DERMAL 500 MG/24 HR] IRRITANT EFFECT: MODERATE SKIN IRRITATION [NIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/8303] IRRITANT DOSE RABBITS DERMAL 5 G/12 DAY INTERMITTENT; IRRITANT effect: MILD SKIN IRRITATION [NIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/8303] IRRITANT DOSE RABBITS OCULAR 100 MG! IRRITANT EFFECT-* MILD EYE IRRITATION INIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/8303] IRRITANT DOSE RABBITS OCULAR 2 MG/24 HR! IRRITANT EFFECT: SEVERE EYE IRRITATION [NIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/8303] TCLO RATS INHALATION 2100 PPM/24 HR (14 DAYS BEFORE MATING, FEMALES/1ST-20TH DAY OF PREGNANCY); TOXIC EFFECT: REPRODUCTIVE; DEVELOPMENTAL [NIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/83031 TCLO RATS INHALATION 2100 PPM/6 HR (10 DAYS BEFORE MATING, FEMALES/1ST-20TH DAY OF PREGNANCY); TOXIC EFFECT: REPRODUCTIVE; DEVELOPMENTAL [NIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/8303) TCLO RATS INHALATION 2100 PPM/6 HR (1ST-20TH DAY OF PREGNANCY); TOXIC EFFECT: REPRODUCTIVE; EMBRYOTOXICITY [NIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/8303] MUTATION SALMONELLA TYPHIMURIUM MUTATION DOSE 1 ML/PLATE [NIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/83031 MUTATION/METABOLIC ACTIVATION SALMONELLA SL 030320 o o. O\ o' O: o o o o o o o o 0001 1,1,1-TRICH LOROETHANB PAGI a NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES NON-HUMAN TOXICITY VALUES ECOTOXICITY VALUES ABSORPTION, DISTRIBUTION AND EXCRETION ABSORPTION, DISTRIBUTION AND EXCRETION ABSORPTION, DISTRIBUTION AND EXCRETION S^ TYPHIMURIUM MUTATION DOSE 1 ML/PLATE INIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/83031 ONCOGENIC TRANSFORMATION RAT EMBRYO CELLS MUTATION DOSE 99 UMOL/L INIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/83031 ONCOGENIC TRANSFORMATION HAMSTER KIDNEY CELLS 562 MG/L INIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/83031 ONCOGENIC TRANSFORMATION HAMSTER EMBRYO CELLS 100 UL/PLATE INIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/83031 LC50 rat Inhalation 24,000 ppm, 1 hr! 18,000 ppm, 3 hr! 14,000 ppm, 7 hr. IVERSCHUEREN. HDBK ENVIRON DATA ORG CHEM 1983 11311 LC50 mouse inhalation 13,500 ppm, 10 hr. IVERSCHUEREN. HDBK ENVIRON DATA ORG CHEM 1983 11311 LD50 female mice single oral 11.24 g/kg. IVERSCHUEREN. HDBK ENVIRON DATA ORG CHEM 1983 6071 LD50 female rabbit single oral 5.66 g/kg. IVERSCHUEREN. HDBK ENVIRON DATA ORG CHEM 1983 11311 LD50 male guinea pig single oral 9.47 g/kg. IVERSCHUEREN. HDBK ENVIRON DATA ORG CHEM 1983 11311 LD50 mice ip 5080 mgAg (95X confidence limits 4,410 to 6,010 mg/kg) [USEPA! Health Assessment Document! 1,1,1-Trichloroethane p.5-16 11982) EPA-600/8-82-0031 AQUATIC TOXICITY: TLM: 10-100 PPM/96 HR INIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/83031 RAPIDLY ABSORBED BY INGESTION, INHALATION & PERCUTANEOUSLY. /TRICHLOROETHANE/ [RUMACK. POISINDEX 1975-PRESENT, p. MGT 4/EXP 63081 AFTER INHALATION IN MICE IT WAS FOUND IN BRAIN & KIDNEY AT APPROX EQUAL CONCENTRATIONS t IN LIVER AT HIGHER CONCENTRATIONS. IN RATS, MORE THAN 98X OF ABSORBED DOSE...RAPIDLY EXPIRED UNCHANGED! 0.57. WAS CONVERTED TO C02. MUCH OF REMAINDER...EXCRETED AS GLUCURONIDE OF 2,2,2-TRICHLOROETHANOL IN URINE. [IARC MONOGRAPHS 1972-PRESENT, p. V20 5241 ...STUDY OF PEOPLE EXPOSED TO...SOLVENTS. ...RATE OF PENETRATION OF AN EQUAL AREA OF SKIN...METHYLENE CHLORIDE...FASTEST, TETRACHLORETHYLENE...SLOWEST, & 1,1,1-TRICHLORETHANE...INTERMEDIATE. ...IT MAY BE CALCULATED...THAT ABSORPTION...DURING 30 MIN WAS ABOUT 62 UG/SQUARE CM/MIN. TRUE l OOOWW4 1,1,1-TRICHLOROETHANE PAW^19 0 RATE.../PROBABLY/ GREATER... (HAYES. TOX OF PESTICIDES 1975 142] ABSORPTION, DISTRIBUTION THERE NAS A HIGH DEGREE OF CORRELATION At EXCRETION BETWEEN ALVEOLAR AIR ARTERIAL BLOOD CONCN. 0 (ASTRAND I ET AL! METHYLCHLOROFORM EXPOSURE: I. CONCENTRATION IN ALVEOLAR AIR AND BLOOD AT REST AND DURING EXERCISE; WORK-ENVIRON-HEALTH 10(2) 69 (1973)1 a ABSORPTION, DISTRIBUTION AND EXCRETION FOLLOWING INTERMITTENT INHALATION EXPOSURE BY ADULT HALE RATS, THE ADIPOSE TISSUE SERVED AS STORAGE SITE. THE FAT-STORED MOLECULES HERE NOT TOTALLY MOBILIZED DURING 0 THE INTERMISSIONS IN EXPOSURE. tSAVOLAINEN H! PHARMACOKINETICS, PHARMACODYNAMICS AND ASPECTS OF NEUROTOXIC EFFECTS OF FOUR INHALED ALIPHATIC CHLOROHYDROCARSON SOLVENTS 0 AS RELEVANT IN MAN; EUR J DRUG METAB PHARMACOKINET 6(2) 85 (1931)3 ABSORPTION, DISTRIBUTION IN HUMAN MALES EXPOSED TO AND EXCRETION 1.1.1-TRICHLOROETHANE (213 OR 72 PPM) FOR 8 0 HR THE ABSORPTION RATE CHANGED CONTINUOUSLY WITH A RETENTION RATE BETWEEN 26-32X. PULMONARY ELIMINATION OVER A PERIOD OF 8 DAYS WAS APPROX 90X. URINARY EXCRETION OF THE METABOLITES (EG, TRICHLOROACETIC ACID W TRICHLOROETHANOL) WAS SLOW LASTED APPROX 12 DAYS. THE URINARY METABOLITES MAY BE USED AS A BIOLOGICAL INDICATOR OF EXPOSURE TO 0 1.1.1-TRICHLOROETHANE. (HUMBERT BE, FERNANDEZ JG, EXPOSURE TO 1,1,1-TRICHLOROETHANE. STUDY OF THE ABSORPTION, EXCRETION AND METABOLISM BY # HUMAN SUBJECTS; ARCH MAL PROF MED TRAV SECUR SOC 38(4-5) 415 (1977)1 ABSORPTION, DISTRIBUTION DOGS INHALING 1,1,1-TRICHLOROETHANE AT 700, AND EXCRETION 1500, & 2000 PPM SHOWED CUMULATIVE UPTAKE AFTER 1 HR OF 27.3, 44.7, 71.2 MG/KG, RESPECTIVELY. EXCRETION AFTER 1 HR WAS 66-77X AT ALL 3 DOSES. DURING THE EXPOSURE, A HIGHLY SIGNIFICANT NEG CORRELATION WAS SEEN BETWEEN THE ARTERIAL/VENOUS BLOOD CONCN RATIO EXPIRED/INSPIRED AIR CONCN RATIO. IN THE POSTEXPOSURE PERIOD, HIGHLY SIGNIFICANT POS CORRELATIONS WERE SEEN BETWEEN EXPIRED AIR CONCN VENOUS OR ARTERIAL BLOOD CONCN. THE MEAN RATIO OF THE TOTAL ABSORPTION VALUE TO THE TOTAL INSPIRED VALUE WAS I4X AT ALL 3 LEVELS OF EXPOSURE. (HOBARA T ET AL; EXPERIMENTAL EXAMINATIONS AND TOXICOKINETIC ANALYSIS OF THE ABSORPTION AND EXCRETION OF 1,1,1-TRICHLOROETHANE BY THE LUNG! SANGYO IGAKU 24(6) 599 (1982)3 SL 030322  1,I,l-TRICHLOROETHANE ABSORPTION, DISTRIBUTION Following exposure of rats to 500 ppm in air o AM) EXCRETION 6 hr/day for 5 days, concn of methyl chloroform in peritoneal fat was much greater than in other organs, but methyl chloroform also detected in cerebellum, liver, cerebrum and blood. tSavolainen et al! Arch Toxicol 38: 29-37 (1977) as cited in USEPA) Health Assessment Document: 1.1.1-Trichloroethane p.4-14 to 4-15 (1982) E PA-6 00/8-62-00 31 METABOLISM/METABOLITES 1.1.1-TRICHLOROETHANE...IS METABOLIZED TO TRICHLOROACETIC ACID (TCA) i TRICHLOROETHANOL (TCE) S EXCRETED AS TCA & TCE IN URINE WITH UNCHANGED TRICHLOROETHANE IN EXPIRED AIR. tRUMACK. POISINDEX 1975-PRESENT, p. MGT 4/EXP 83083 METABOLISM/METABOLITES SMALL PERCENTAGE IS METABOLIZED TO CARBON DIOXIDE, WHILE REMAINDER APPEARS IN URINE AS GLUCURONIDE OF ,2,2-TRICHLOROETHANOL. EENCTC OCCUPAT HEALTH t SAFETY 1971 14321 METABOLISM/HETABOLITES INCUBATION OF CHLOROETHANES, HEPATIC MICROSOMES, AN NADPH-GENERATING SYSTEM t EDTA RESULTS IN PRODUCTION OF CHLORINATED METABOLITES. 1,1,l-TRICHLOROETHANE IS o CONVERTED BY HEPATIC MICROSOMAL CYTOCHROME P-450 TO 2i,2-TRICHLOROETHANOL. CIVANETICH * KM, VAN DEN HONERT LH! CHLOROETHANES: THEIR METABOLISM BY HEPATIC CYTOCHROME P-450 IN VITRO! CARCINOGENESIS 2(8) 697 (1981)3 o BIOLOGICAL HALF-LIFE 8.7 + or - 1.8 hr (in humans). [Seki YJ Int Arch Arbeitsmed 34: 39-49 (1975) as cited in NIOSH; Criteria Document: O' 1.1.1-Trichloroethane (reprint) p.34 (1979) DHEW Pub. NIOSH 76-1843 % BIOLOGICAL HALF-LIFE Human half-life of elim was calculated for the following compartments: vessel-rich tissues (0.8 hr), muscle and skin (7 hr), adipose tissue (35 hr) following exposure of m subjects to 72 and 215 ppm methyl chloroform. (Humbert BE & Fernandez JGj Arch ( Mai Prof 38: 415-25 (1977) as cited in USEPA; Health Assessment Document: & 1,1,1-Trichloroethane p.4-16 (1982) EPA-600/8-82-0033 MECHANISM OF ACTION Mechanism of 1,1,1-trichloroethane-induced ventricular fibrillation was studied in mice. Adrenalectomized mice and mice treated with a empd (P-286), which blocks the release of adrenal catecholamines, were not protected from 1,1,1-trichloroethane-induced fibrillation. The mice, whether adrenalectomized or not, were protected by o 033*3 w 0000 & INTERACTIONS & INTERACTIONS * INTERACTIONS <60 # # # INTERACTIONS m m st# 03032* # 1,1,1-TRICH LOROETHANE PAGI 1 reserpine and particularly by the beta-blocker> propanolol. [Strosberg AH et al; Fed Proc 32: 3178 (1973) as cited in NIOSH; Criteria Document: liI, 1-Trfchloroethane (reprint) p.91-92 (1979) DHEW Pub. NIOSH 76-1891 ...PRETREATMENT OF RATS WITH PHENOBARBITONE POTENTIATED HEPATOTOXICITY OF ltlil-TRICHLOROETHANE...GIVEN BY INHALATION. [FOREIGN COMPD METAB IN MAMMALS VOL3 1975 6111 A 29 HR INHALATION OF METHYLCHLOROFORM BY MALE MICE DECR SODIUM HEXOBARBITAL (80 MG/KG) INDUCED HYPNOSIS, BUT HAD NO EFFECT ON SODIUM BARBITAL OR CHLORAL HYDRATE INDUCED HYPNOSIS. IUL H, SHAH HC; EFFECT OF METHYLCHLOROFORM INHALATION ON BARBITURATE HYPNOSIS AND HEPATIC DRUG METABOLISM IN MALE MICE, TOXICOL APPL PHARMACOL 17(3) 625 (1970)1 ACUTE BEHAVIORAL LETHAL EFFECTS OF ORAL ETHANOL INHALED 1,1,1-TRICHLOROETHANE (TCE) ALONE & IN COMBINATION HERE DETERMINED IN MICE. FOR LETHALITY, ETHANOL SHIFTED TCE CONCN-EFFECT CURVE TO LEFT IN PARALLEL MANNER, WITH MAGNITUDE OF SHIFT DIRECTLY RELATED TO DOSE OF ETHANOL. COMBINATIONS OF LOW DOSES OF ETHANOL WITH TCE WERE USUALLY SUPRAADDITIVE, WHILE HIGHER DOSES OF ETHANOL WERE ADDITIVE OR INFRAADDITIVE WITH TCE. SHIFTS TO LEFT OF TCE CONCN-EFFECT CURVES FOR BEHAVIORAL TESTING SIMILARLY DEPENDED ON DOSE OF ETHANOL, BUT WERE NONPARALLEL. PROBABLY, IN MANY COMBINATIONS, SIGNIFICANT ACUTE TOXICITY MAY OCCUR WITH JOINT ADMIN. HEALTH HAZARDS TO WORKERS WHO INGEST ETHANOL PRIOR TO ON-THE-JOB EXPOSURE TO TCE ARE DISCUSSED. [WOOLVERTON WL, BALSTER RLi BEHAVIORAL AND LETHAL EFFECTS OF COMBINATIONS OF ORAL ETHANOL AND INHALED 1,1,1-TRICHLOROETHANE IN MICE! TOXICOL APPL PHARMACOL 59(1) 1 (1981)1 Male Sprague-Dawley rats and Swtss-albino, random bred mice were exposed to methyl chloroform (2500-3000 ppm) in a dynamic chamber for 29 hours. Loss of righting reflex due to hexobarbi tal (120 vng/kg), or zoxazolamine (80 mg/kg) administration and in vitro activity of hexobarbital oxidase, zoxazolamine hydroxylase, aminopyrine demethylase, reduced nicotinamide adenine dinucleotide phosphate (NADPH) cytochrome c DO '7 1,1.1-TRICHLOROETHANE PAI 22 POPULATIONS AT SPECIAL RISK' ENVIRONMENTAL FATE/EXPOSURE SUMMARY NATURAL OCCURRING SOURCES reductase* and CO-binding (cytochrome p-450) were then measured . Pretreatment with inhibitors of protein synthesis (cycloheximide and actinoraycin-D) were used to block the effect of methyl chloroform on the hepatic drug-metabolizing system. Inhalation of methyl chloroform (2500-3000 ppm) for 24 hours decreased the duration of action of hexobarbital> meprobamate* and zoxazolamine. This was accompanied by an increase in the metabolism of hexobarbital* zoxazolamine and aminopyrine in vitro by hepatic microsomal enzymes. Cytochrome p-450 and cytochrome c reductase were also increased* however* liver weight and liver microsomal protein were not enhanced. Rretreatment of rats with protein synthesis inhibitors prevented methyl chloroform induced decrease in hexobarbital sleeping time and the increase in hepatic drug metabolism. (Fuller GC et al* J Pharmacol Exp Ther 175: 311-317 (1970) as cited in USEPA! Health Assessment Document: 1*1il-Trichloroethane p.5-19 (1982) EPA-600/8-82-003) Preclude from exposure individuals with diseases of the liver or kidney. (ITI. TOX & HAZARD INDUS CHEM SAFETY MANUAL 1982 536) 1*1*I-Trichloroethane is likely to enter the environ from air emissions or in wastewater from its production or use in vapor degreasing* metal cleaning* etc. (see also MANF). Releases to surface water will deer in concn almost entirely due to evap. Spills on land will decrease in concentration almost entirely due to volatilization and percolation into groundwater. Releases to air will be transported long distances and partially return to earth in rain. In the troposphere* it will degrade very slowly by photooxidation. Part will diffuse to the stratosphere where photodegradation will be rapid. Major human exposure is from air and drinking water. Exposure can be high near sources of emission or where drinking water is contaminated.(SRC) Nonet SRC) ARTIFICIAL SOURCES Wastewater and stack effluent from production; volatilization losses from its use in the cold cleaning of metals* vapor degreasing and as a solvent and aerosol* SL 030325 I # # I :# '# i # :m I# :* ;^ # m m m oooooUF 11.1-TRICH LOROETHANE PAGE ENVIRONMENTAL FATE ENVIRONMENTAL FATE ENVIRONMENTAL FATE BIODEGRADATION SL 030326 etc.(l) t(l) USEPAl Source Assessment ' Chlorinated Hydrocarbon Manufacture (1979) EPA-600/2-79-019G] TERRESTRIAL FATE-- Evapor fairly rapidly into the atmosphere because of its high vapor pressure. Passes rapidly through soil into groundwater<1).(SRC) t(l) Schwarzenbach RP et all Environ Sci Technol l?:472-9 (1983)] AQUATIC FATE: Primary loss will be by evaporation into the atmosphere. Half-life will range from hours to several weeks depending on wind and mixing conditions. Biodegradation and abiotic degradation will be insignificant in most cases(1).(SRC) CCD Nakeham SG et alt Environ Sci Technol 17:611-7 (1983)1 ATMOSPHERIC FATE - 1,1,1-trichloroethane is fairly stable in the atmosphere and is transported long distancest being found even at the south poledt23). It Is transported to Barrowst Alaska from the mid-latitudes(l). It is slowly.degraded principally by reaction with hydroxyl radicals and has a half-life of 6 months to 2 years (see also ABIO)(2>4). The rate of degradation is increased by the presence of chlorine radicals and nitrogen oxides (see also ABIO). 15Z of the 1>1il-trichloroethane drifts into the stratosphere where it is rapidly degraded by photodissociation (see also ABIO)(2i4). Due to the large input of l>lil-trichloroethane Into the atmosphere and its slow degradation the amount of ll>l-trichloroethane in the atmosphere is increasing by 12-17JJ a year(6>4). Some of the l,lfl-trichloroethane returns to earth in rain as is evidenced by its presence in rainwater and a 40/! reduction in air concentrations on rainy days(5). C(l) Khalil MAK, Rasmussen RA; Environ Sci Technol 17:57-64 (1983) (2) Battelle Columbus Labs) Multimedia Levels: Methylchloroform page 3-1 to 3-6 EPA-560/6-77-030 (1977) (3) Rasmussen RA et all Science 211:285-7 (1981) (4) Callahan MA et all Nater-related Environmental Fate of 129 Priority Pollutants Vol II p 45-1 to 45-12 Epa-440/4-79-029B (1979) (5) Ohta T et all Atmos Environ 11:985-7 (1977) (6) Khalil MAK Rasmussen RAl J Air Pollut Control Assoc 31:1274-5 (1981)] Not or very slow degradation in soils. No m 000^^9 1,1.l-TRICH LOROETHANE PAI r29 degradation has been observed in subsurface soils in 27 weeks; however in loamy sand, slow degradation has been observed under acclimated conditions (1,2). Slow degradation may occur in water under anaerobic or aerated conditions; degradation may take several weeks and acclimation is important (3,9). In seawater, a half-life of 9 months has been determined and vinylldene chloride is the degradation product(5). No m degradation in river water has been found(6). id) Wilson JT et al; Devel Indust Microbiol 29:225-33 (1983) (2) Bouwer EJ et al; Water Res 15U51-9 (1981) (3) Bouwer EJ, McCarty PL; Appl Environ Microbiol 95:1286-99 (1983) (9) Tabak HH et al; J Water Pollut Control Fed 53:1503-18 (1981) (5) Pearson CR, McConnell G; Proc Roy Soc London B 189:305-32 (1975) (6) ttudder TI! Amer Chem Soc Div Environ Chem p 52-3, ABIOTIC DEGRADATION Kansas City, MO (1982)) Hydrolysis is not a significant degradation % process having a half-life of approximately 6 monthstl,2).. Direct photolysis is not important in the troposphere since 1.1.1-trichloroethane does not absorb light % above 290 nm. In the stratosphere, photolysis is important and leads to the chemical's rapid degradation(2,3). 1.1.1-Trichloroethane reacts slowly with * hydroxyl radicals which is producted by sunlight in the atmosphere. Estimates of t half-life in the troposphere range from 0.5 to 2.2 years, much slower than unsaturated % chloroalkanes, but much greater than completely chlorinated compounds such as carbon tetrachlordel,9,5). Products of photooxidation include phosgene, Cl2, HC1, % and C02(6,7>. Degradation is reported to be greatly increased by exposure to gone and chlorine but no actual data could be found in regard to 1,1,1-trichloroethane's % reactivity with ogone(7). On expose to nitrogen oxide, less than S'/, degradation occurs in 8 hours<8). There is some evidence that photodegradation is catalysed by surfaces which results in complete degradation within 2 weeks(9). Indirect evidence of photodegradation comes from the fact that levels of 1,1,1-trichloroethane are lowest in the afternoon and 6/. less on sunny days than cloudy ones(lO). o SL 030327 ,) 0 # m # # # # # # 00000 1,1,1-TRICHLOROETHANE PAGE BIOCONCENTRATION HATER CONCENTRATIONS 030^ Photodegradation does not occur in water(2). [(1) Callahan HA et al; Hater-Related Environmental Fate of 129 Priority Pollutants Vol II page 45-1 to 45-12 EPA-440/4-79-029B (1979) (2) Dilling NL et al! Environ Technol 9:633-3 (1975) (3) Hubrich C, Stuhl FJ J Photochem 12:93-107 (1980) (4) Singh HB et al; Atmos Environ 15:601-12 (1981) (5) Hampson RF! FAA-EE-80-17, US Dept of Transportation (1980) (6) Pearson CR, McConnell G; Proc Roy Soc London B 189:305-32 11975) (7) Spence JH, Hanst PL! J Air Pollut Control Fed 28:250-3 (1978) (8) Dilling WL et al; Environ Sci Technol 10;351-6 (1976) (9) Buchardt 0, Manscher OH; CEC Proceedings, 2nd Meeting (1978) (10) Singh HB et al; Environ Sci Technol 16;872-80 (1982)1 Little or no tendency to bioconcentrate. Based on limited experimental data the log BCF is 1.0 in fish. Confidence is increased because values in related compounds are sitnilar(l). Nl) Barrows ME et al; Dyn Exp Hazard Assess Toxic Chem Ann Arbor Mi: Ann Arbor Sci p 379-92 (I960)) DRINKING HATER - 133 Uhited States cities with finished surface water - .4 ppb median, 3.3 ppb max; 23 lAiited States cities with finished groundwater - 2.1 ppb median, 3.0 max, 22V. of the samples were positive(l). Contaminated drinking water wells in New York, New Jersey, Connecticut and Maine have values of 950-5440 ppb(2). GROUNDWATER - Raw groundwater In 13 Uhited States cities - 1.1 ppb median, 13 ppb max, 23Z were positive(l). SURFACE HATER - Raw surface water in 105 United States cities - 0.2 ppb median, 1.2 ppb max, 12/f positive(l). Large study of the Ohio R. Basin in 1980-1981 (4972 samples) reports 33.6K of samples above 0.1 ppb, 3.9/i between 1.0 and 0.3K above 10 ppb(3). In a study of 14 heavily industrialized river basins in 1975-1976, 9X of the sites had values above 1 ppb, and 8 ppb was the maximum value measured(4). At industrial sites, mean values are above 10 ppb with maximum values as high as 334 ppb(5). Concentration 20-800 meters away from outfalls of four producing plants and 1 user was 0.1-169 ppm(6).SEAHATER - Liverpool Bay seawater averaged <.25 ppb, 3.3 ppb maximum<7). RAIN HATER - Hest Los Angeles ft ft m o :> v ' o 1,1,1-TRICHLOROETHANE EFFLUENTS CONCENTRATIONS SEDIMENT/SOIL CONCENTRATIONS SL 030329 26Mar82 - 69 parts/trillion(8); La Jolla, Ca - 8.1 parts/trillion(9); an industrial area of England - .9 parts/triIlfont7). SNOW Southern California 6.2 parts/trillion, central California - .6 parts/trillion, Alaska 27 parts/triHiont7J. [(1) Coniglio WA et ali EPA Briefing. Criteria and Standards Div. Sci Technol Branch. Exp Assess Pro) p 16 (1980) t2J Brumaster OEi Environ 29:6-13, 33-6 (1982) (3) Ohio River Valley Water Sanit Coram; Assess of Water Qual Cond 1980-81 Cincinnati, OH (1982) (9) Ewing BB et al; Monitoring to detect previously undetected pollutants in surface waters. Appendix: organic analysis data p 1-129 EPA-560/6-77-015A (1977) (5) Pelllzzari ED et al; Formulation of preliminary assessment of halogenated organic compounds in man and environmental media p 38-99 EPA-560/13-79-006 (1979) (6) Bat telle Columbus labs; Multimedia levels methylchloroform p 2.1-2.22 EPA-560/6-77-030 (1977) (7) Pearson CR, McConnell G; Proc Roy Soc London B 189:305-32 (1975) (8) Kawamura K> Kaplan LR; Environ Sci Technol 17:997-501 (1983) (9) Su C, Goldberg ED; Marine Pollut Tfr HL Windom et al eds Lexington HA: DC Heath Co p 353-79 (1976)] Mean values in raw wastewater of 15 industries range from 3.6 to 38,000 ug/1 with the maximum value range from 10 to 1,300,000 ug/1. The highest values were for the metal finishing industry(l). Mean value of treated wastewater for 11 industries 0.6-89 ug/1 with maximum values ranging from 0.6 to 7100 ug/l(l). 18-399 ppb outfall from producing plants(2). ttl) USEPAJ Treatability Manual page 1.12.8-1 to 1.12.8-9 EPA-600/2-82-00la (1982) (2) Battelle Columbus Labs! Multimedia levels methylchloroform p 2.1-2.22 (1977)] Liverpool Bay marine sediment <5.5 ppb(l). Soil around production plants and user industry 0.06-0.99 ppb; sediment upstream and downstream of production plants and user industry 0.039-2.6 ppb! average background concentration in soil (St. Francis National Forest) 0.92 ppb; average background concentrat ion in sediment (St. Francis National Forest) 0.95 ppb(2). C(l) Pearson CR, McConnell G; Proc Roy Soc London B 189:305-32 (1975) (2) Battelle Columbus 0 0 G O  ; 000 PAS1 7 1,1,1-TRICHLOROETHANE ATMOSPHERIC CONCENTRATIONS FOOT SURVEY VALUES PLANT CONCENTRATIONS FISH/SEAFOOD CONCENTRATIONS ANIMAL CONCENTRATIONS 030330 SL Labs! Multimedia Levels Methylchloroform p .1-2.22 EPA-560/6-77-030 (1977)1 Rural/remote sites (1977-1980) - 60-156 parts/trillion, 110 parts/trillion av(l-3). Yearly rate of increase is 12-17/(/yeart 1,2). Urban/suburban areas (1977-1980) - 420 parts/trillion av, 700-8000 parts/trillion maximum, <20X samples may be positive(3-6). Source dominated areas (1977-1980) - 1200 parts/trillion av(3). Although maximum values are usually under 10 ppb, one maximum value of 111 ppb has been reported in New Jersey(7). [(1) Rasmussen RA et al; Science 211:285-7 (1981) (2) Singh HB et al; Atmospheric distribution, sources and sinks of selected halocarbons, hydrocarbons, SF6 and N20. p 114-22 EPA-600/3-79-107 (1979) (3) Brodzinsky R, Singh HB! Volatile organic chemicals in the atmosphere: an assessment of available data, p 12-5 SRI Inter contract 68-02-3452 (1982) (4) Bozzelli JH, Kebbekus BB; Analysis of selected volatile organic substances in ambient air. Air Force Final Report, Apr-Nov 1978 Newark, NJ: NJ Inst Technol 80 pp (1979) (5) Singh HB et al; Atmos Environ 15:601-12 (1981) (6) Singh HB et al; Atmospheric measurement of selected hazardous organic chemicals EPA-600/S3-81-032 (1981) (7) Pellizzar! ED et al; Formulation of preliminary assessment of halogenated organic compounds in man and environmental media p 38-94 E PA-560/13-79-0 06 (1979)3 5-10 ng/g oils and fats! 1-4 ng/g friuts and vegetables; 2-7 ng/g meat, tea, bread(l). (tl) McConnell G et al; Endeavor 34:13-8 (1975)3 <9.4-35 ppb (in analytical work CCL4 was not separable from 1,1,1-trichloroethane ) in marine algae(l). t(l) Pearson CR, McConnell G; Proc Roy Soc London B 189:305-32 (1975)3 3 species of fish, mollusks in Irish Sea 2-16 ppb(l). Flesh of nine samples of various fish from Liverpool Bay and Thames Estuary - 0-5 ppb, gut contained up to 26 ppb(2). Marine invertebrates in bays and estuaries of Great Britain - 0-34 ppb(2). t(l) Dickson AG, Riley JP; Marine Pollut Bull 7:167-70 (1976) (2) Pearson CR, McConnell G; Proc Roy Soc London B 189:305-32 (1975)3 <16-30 ppb gray seal blubber, <2.3-7 ppb 000011503 1,1,1-TRICH LOROETHANE PAGE^ 28 PROBABLE ROUTES OF HUMAN EXPOSURE AVERAGE DAILY INTAKE PROBABLE EXPOSURES BODY BURDENS SOIL ADSORPTION/MOBILITY common shrew, <1.1-4.7 ppb in flesh or organs of fresh- and seawater birds, <4,2-43 ppb in eggs of fresh- and seawater birds (in analytical work CCL4 was not separable from 1.1.1-trichloroethane) (1). [(1) Pearson CG, McConnell Gi Proc Roy Soc London B 169:305-32 (1975)1 Huranas are primarily exposed to 1.1.1-trichloroethane from ambient air. drinking water, and food. Although the data for food levels is fragmentary, this may be a major source of human exposure for those persons without occupational expoure. Contaminated drinking water may be an important source of exposure if it is from contaminated groundwater sources. (SRC) AIR INTAKE - rural(assume 110 parts/trillion, see also ATMC) - 12.2 ugt urban/suburban (assume 420 parts/trillion, see also ATMC) - 46.5 ug; residents in source dominated areas (assume 1200 parts/trillion, see also ATMC) - 133.0 ug. WATER INTAKE - surface water source (assume 0.4 ppb, see also WATC) - .9 ugi groundwater source (assume 2.1 ppb, see also WATC) - 4.2 ug. FOOD INTAKE - insufficient data. 1.5-350 ppm in ambient air of various industries (deqreasing, metals, electrical, etc HI). E(l) USEPAi Ambient Water Quality Criteria for Chlorinated Ethane page C5-C13 EPA-440/5-60-029 (1980)1 Body fat of 8 subjects - 1.6-24 ng/g, various organs - <5.1 ng/g(l). Sample residents of Old Love Canal, breath - 290 ng/m3 median, 2800 ng/m3 maximum, blood .85 ng/ml median, 2.0 ng/ml maximum, urine 60 ng/1 median, 180 ng/1 maximum(2). Detected in all eight samples of mother's milk from four urban areas(3). ((1) McConnell G et ali Endeavour 34:13-8 (1975) (2) Barkley J et ali Biomed Mass Spectrom 7:139-47 (1980) (3) Pellizzari ED et ali Environ Sci Technol 16:78-5 (1982)1 Little work has been done on the adsorption of 1,1,1-trichloroethane to soil(l). It is adsorbed strongly to peat moss, less strongly to clay, very slightly to dolomite limestone and not at all to sand(2). It has a low adsorption to silt loam (KOC = 183)(3). From the fact that it is not retained in the soil during bank infiltration, and that it is frequently SL 030331 000 14 # 1,1.1-TRICHLOROETHANE PAGf~29 found tn groundwater tn high concentrations* one can safely conclude that it is not adsorbed strongly by soils* especially subsurface soils(l). Cfl) Schwar2enbach RP et al; Environ Sci Technol 17:472-9 (1983) (2) Dilling WL et al! Environ Sci Technol 9:833-8 (1975) (3) Chiou CT et al; Science 206:831-2 (1979)] # VOLATILIZATION FROM WATER/SOIL ldtl-trichloroethane has a high Henry's Law constant (high vapor pressure and low solubility) and will volatize rapidly from water and soil(l). Half-life for evaporation from water obtained from laboratory systems range from a fraction of an hour to several hours(2). Loss tn a mesocosm is entirely due to evaporation and range from a half-life of 24 days in spring to 11 days in winter(3). (1) Shen TT; J Air Pollut Control Assoc 32:79-82 (1982) (2) Dilling WL et al; Environ Sci Technol 9:833-8 (1975) (3) Wakeham SG et al; Environ Sci Technol 17:611-7 (1983)1 IMMEDIATELY DANGEROUS TO 1DLH level:1000 ppm CNIOSHi Pocket Guide to LIFE OR HEALTH Chemical Hazards p.128 (1981) DHEW (NIOSH) Pub No 78-210] OSKA STANDARDS MEETS CRITERIA FOR PROPOSED OSHA MEDICAL RECORDS RULE, FEREAC 47,26992,82. CNIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/83033 OSHA STANDARDS OSHA STD- AIR: TIME WEIGHTED AVG 350 (TWA) PPM (1974). CNIOSH. RTECS ONLINE FILE, CURRENT FILE, p. 83/83031 NIOSH RECOMMENDATIONS Occupational exposure shall be controlled so that workers are not exposed to 1,1>l-trichloroethane at greater than a ceiling concentration of 350 ppm (1,910 mg/cu m) as determined by a 15-minute sample. CNIOSH; Criteria Document: 1.1.1- Trichloroethane (Methyl Chloroform) p.l (1976) DHEW Pub. NIOSH 76-184] THRESHOLD LIMIT VALUES TLV; TIME WEIGHTED AVG CTWA) 350 PPM (APPROX 1900 MG/CU M); SHORT TERM EXPOSURE LIMIT (STEL) 450 (APPROX 2450 MG/CU M) (1982). (ACGIH. TLVS 1982 p231 WATER STANDARDS Ambient water criterion for 1.1.1- trichloroethane ingested through water and contaminated organisms is 18.4 mg/1. Ingested through contaminated organisms alone, the ambient water criterion Is 1.03 g/1. C45 FR 79328. 11/28/80)] CERCLA REPORTABLE 1000 lb or 454 kg C48 FR 23552. 5/25/83] QUANTITIES TSCA REQUIREMENTS Reported in EPA TSCA inventory. CNIOSH! # SL 030332 00007505 o 1,1.1-TRICH LOROETHANE PAI 30 RCRA REQUIREMENTS SAMPLING PROCEDURES ANALYTIC LABORATORY METHODS ANALYTIC LABORATORY METHODS SPECIAL REPORTS SPECIAL REPORTS TEST STATUS TEST STATUS TEST STATUS 030333 su RTECS Online File, Current File 19843 Toxic waste, subject to the small quantlt exclusion defined in 40 CFR 861.5(a) and (f). (40 CFR 261.33(f). 7/1/83] VAPOR CONCN IN WORK AREAS MAY BE MEASURED BY MONITORING BREATHING ZONE CONCN BY USE OF EXPIRED BREATH ANALYSIS IN POST-EXPOSURE PERIOD IN ORDER TO EST MAGNITUDE OF EXPOSURE. CENCYC OCCUPAT HEALTH SAFETY 1971 14323 MATRIX: AIRJ PROCEDURE: ADSORPTION ON CHARCOAL, DESORPTION WITH CARBON DISULFIDE, GC. [NIOSH MANUAL ANALY METH VOL1-7 1977-PRESENT, p. V3 S3283 SIMPLE LONG-PATH LASER ABSORPTION HETHOD FOR RESOLVING MIXTURES OF CLOSELY RELATED TRACE CONTAMINANTS AT PPM LEVELS IS DESCRIBED. [GREEN BO, STEINFIELD JI; MONITORING COMPLEX TRACE-GAS MIXTURES BY LONG-PATH LASER ABSORPTION SPECTROMETRY; PROC SOC PHOTO-OPT INSTRUM ENG 99(ISS PROC EUR ELECTRO-OPT CONF EXHIB, 3RD) 32 (1977)3 REVIEW: CASTRAND I; UPTAKE OF SOLVENTS IN THE BLOOD AND TISSUES OF MAN. A REVIEW; SCAND J WORK, ENVIRON HEALTH 1(4) 199 (1975)3 A REVIEW OF RESULTS FROM STUDIES ON UPTAKE IN HUMAN. [PEER REVIEW COMMITTEE] REVIEW: [WALTER P ET AL; CHLORINATED HYDROCARBON TOXICITY (1,1,1-TRICH LOROETHANE, TRICHLOROETHYLENE, AND TETRACHLOROETHYLENE): A MONOGRAPH; US NTIS, PB REP (ISS PB-257185) 178 (1976)] A REVIEW WITH 91 REF. RESULTS OF THE 1920-1975 LITERATURE STUDY ON PHYSICAL & CHEM PROPERTIES, ANALYTICAL METHODS, OCCURRENCE, USE BY INDUSTRY, USE IN CONSUMER PRODUCTS, BREAKDOWN, SHORT-TERM TOXICOLOGY STUDIES, LONG-TERM TOXICOLOGY STUDIES, ABSORPTION-DISTRIBUTION, METABOLISM-EXCRETION, EFFECTS ON ENZYMES DRUG INTERACTIONS. [PEER REVIEW COMMITTEE] On test in FY 1983 for mutagenesis/genetic toxicity by Columbia Univ (M01-ES-9-0014) and Litton Bionetics, Inc (N01-ES-9-0013). [US DHHS, NTP, Review of Current DHHS, DOE, EPA Research Related to Toxicology. 19831 Carcinogenesis testing is to be completed in FY 1983 by Tracor-Jitco (NO l-CP-43350). [US DHHS, NTP, Review of Current DHHS, DOE, EPA Research Related to Toxicology. 19833 Mutagenesis/genetic toxicity testing is to be completed in FY 1983 by SRI-International (N01-CP-65854) and Litton Bionetics, Inc 00000506 1,1>1-TRICH LOROETHANE PAGE 31 ##* END OF (NOl-CP-65653). tUS DHHS, NTP, Review of Current DHHS, DOE, i EPA Research Related to Toxicology. 19831 OFFLINE PRINT * * tt 030^ S*> Q #* * THIS IS AN OFF-LINE BIBLIOGRAPHIC CITATION LIST GENERATED BY * *# <J * * MEDLARS II * tt * N.L.M.'S NATIONAL INTERACTIVE RETRIEVAL SERVICE * ** * O K o 1,1,1 -TRICH LOROETHANE NUMBER OF CITATIONS PRINTED = 20 THIS SEARCH NAS PERFORMED ON THE TOXBACK65 MAY 20, 1966 FILE. u SORT = (ELEMENTS/DIRECTIONS GIVEN BY USER) WAS SPECIFIED o PLEASE SEND THIS LISTING TO o o o DIANA DANKO / PPG INDUSTRIES,INC. P.0. BOX 31 o BARBERTON, OHIO 49203 SL 030335 o o 1 SECONDARY SOURCE ID ADDRESS TITLE SOURCE LANGUAGE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 2 SECONDARY SOURCE ID AUTHOR c AUTHOR AUTHOR AUTHOR TITLE r) SOURCE CODEN ' O ABSTRACT o o ,^ o SL 030336 J 1,1,1-TRICHLOROETHANE 0 CA/087/20586AC Off. Stand., Washington, D. C. Ethylene dichloride, methylchloroform, tetrachloroethylene, 1,1,2-trichloroethane, set J (part 21 U. S. NTIS, PB Rep.; ISS PB-267223,, 1975,52 pp. ENG XPBRC CBAC COPYRIGHT: CHEM ABS Draft tech. stds. are outlined for ethylene dichloride, methylchloroform, tetrachloroethylene, and 1.1.2-trichloroethane. (107-06-2 1.2- Dichloroethane)(71-55-6 Methylchloroform H127-18-4 Tetrachloroethylene It 79-00-5 1.1.2-Trichloroethane) Each std. includes difinitions, monitoring requirements, methods of compliance, procedures for respiratory and personal protection, medical surveilance, and recordkeeping. Appendicies for each std. includes health hazard data! emergency and first aid procedures; precautions for safe use; handling and storage; phys. and chem. data! fire, explosion and reactivity hazard data; and spill or leak procedures. 107-06-2; 71-55-6; 127-16-4; 79-00-5 7802 HEEP/74/05562 ASTRAND I KILBOM A WAHLBERG I OVRUM P Methylchloroform exposure: I. Concentration in alveolar air and blood at rest and during exercise. WORK-ENVIRON-HEALTH*, 10 (2). 1973 69-81 WEHRB HEEP COPYRIGHT: BIOL ABS. Twelve healthy subjects were exposed to approximately 250 and 350 ppm of methylchloroform in air during rest and physical exercise on a bicycle ergometer. The duration of exposure for each subtrial was 30 min. Pulmonary ventilation, cardiac output and methylchloroform concentration in alveolar air, and arterial and venous blood were determined during and after exposure. The concentration in alveolar air and arterial blood was of the same magnitude at an exposure to 350 ppm at rest as at 250 ppm during light exercise. As o o o o o o o 0 a 0 $ w O' 00C^p2 1,1,1-TRICH LOROETHANE PAG^ 2 r'* o I} o CAS REGISTRY NUMBER ENTRY MONTH 3 SECONDARY SOURCE ID AUTHOR ADDRESS TITLE o SOURCE o LANGUAGE CODEN ABSTRACT SL 030337 5I exercise intensity increased a kind of levelling-off value was obtained for alveolar air and blood at each exposure level. Increased ventilation was more important to the increase in alveolar air and arterial blood concentrations than increased circulation. There was a high degree of correlation between alveolar air and arterial blood concentrations. The concentration in alveolar air at the termination of exposure could be calculated on the basis of 3 alveolar air samples taken after exposure only if the samples were taken within half an hour after terminated exposure. Venous blood concentration rose in step with the rise in arterial blood concentrations so that the arterio-venous difference remained relatively constant, except at the highest work load of 150 H at which the difference was less. 71-55-6 7407 CA/079/112178B Carlson GP Coll. Pharm.t Unlv. Rhode Island, Kingston, R. I. Effect of phenobarbital and 3-methyleholanthrene pretreatment on the hepatotoxicity of l>ltl-trichloroethane and 1,1,2-trichloroethane Life Sci. ; VOL 13, ISS 1, 1973,67-73 Eng LIFSA CBAC COPYRIGHT: CHEM ABS Pretreatment of rats with phenobarbital (50 mg/kg/day, i.p., for 4 days) potentiated the hepatotoxicity of 1>1,2-trichloroethane> and to a lesser extent 1.1.1-trichloroethane, given by inhalation (890 ppm for 2 hr). (50-06-6 Phenobarbital)(79-00-5 1.1.2-Trichloroethane)(71-55-6 1,1,1-Trichloroethane ) 3-methylcholanthrene pretreatment (40 mg/kg/day, i.p., for 2 days) did not potentiate the hepatoxicity of either compd. (56-49-5 3-Methylcholanthrene) Rats pretreated with phenobarbital and exposed to trichloroethane had enlarged livers, decreased glucose 6-phosphatase activity, a 6-fold increase in serum glutamic-oxalacetic transaminase, and a 4-fold increase in glutamic-pyruvic transaminase. (9001-39-2 Glucose 6-phosphatase)(9000-97-9 Glutamic-oxalacetic transaminase )(9000-86-6 000' 3 1,1,1-TRICH LOR0ETHANE PAGE .J i Glutamic-pyruvic transaminase) However only enlarged livers occurred in rats pretreated with methylcholanthrene and exposed to CAS REGISTRY NUMBER trichloroethane. 50-06-65 79-00-5; 71-55-6; 56-49-5; ; ENTRY'MONTH 9001-39-2; 9000-97-9; 9000-86-6 7312 oI 4 SECONDARY SOURCE ID AUTHOR AUTHOR TITLE HEEP/74/09701 EBEN A KIMMERLE G Metabolism, excretion and toxicology of methylchloroform in acute and subacute t i o exposed rats. SOURCE ARCH TOXIKOL; 31 (3). 1974 233-242 CODEN ABSTRACT ATXKA HEEP COPYRIGHT: BIOL ABS. In acute and o subacute inhalation studies rats were exposed to methylchloroform. In the 4-h exposure the "A concentrations were approximately 220 and 440 o ppm, and in the 3-mo. study (5x8 h/wk) approximately 204 ppm (maximum allowable concentration, MAC = 200 PPM). The behavior of methylchloroform and its metabolites (trichloroethanol and trichloroacetic acid) 0 in the expired air, blood, and urine was investigated. A gas-chromatographic method for the determination of methylchloroform is described. Most of the methylchloroform is 0 eliminated unchanged via the lungs. In the subchronic inhalation studies, o methylchloroform concentrations within the range of the MAC were tolerated with no o symptoms. During this time, the concentrations of methylchloroform and o atrichloroethanol in the blood and the concentration of trichloroacetic acid in the urine remained constant. The urinary trichloroethanol excretion increased until o athe 10 wk, then fell and remained constant at a level somewhat below the maximum concentration. Methylchloroform was not CAS REGISTRY NUMBER detectable in organ tissue. The results of the metabolic studies are discussed. 115-20-8, 71-55-6, 76-03-9 a ENTRY MONTH 7407 oa ,1 Q ai st 030338 m 00' PA1 4 1,1,1-TRICHLOROETHANE 5 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE LANGUAGE CODEN ABSTRACT n r\ CAS REGISTRY NUMBER ENTRY MONTH 6 SECONDARY SOURCE ID AUTHOR AUTHOR TITLE SOURCE CODEN ABSTRACT o & 51 SL 030339 CA/013/000298W Fuller GC Olshan AM Puri SK Lai H Dep. Pharmacol. Toxicol., Univ. Rhode Island, Kingston, R. I. Induction of hepatic drug metabolism in rats by methylchloroform inhalation J. Pharmacol. Exp. Ther.i VOL 175, ISS 2> 1970,311-17 Eng JPETA CBAC COPYRIGHT: CHEM ABS Inhalation of MeCC13 (2500-3000 ppm) by rats for 24 hr decreased the duration of action of hexobarbital (I), meprobamate, and soxa2olamine (II), this effect being accompanied by an increase in the metabolism of I, II, and aminopyrine in vitro by hepatic microsomal enzymes. (50-09-9 HexobarbitalK57-53-4 Meprobamate H61-80-3 Zoxazolamine )(58-15-1 Aminopyrine) Cytochrome P-450 content and NADP-cytochrome c reductase activity of hepatic microsomal fractions were increased following MeCC13 inhalation. Pretreatment of rats with cycloheximide or actinomycin 0 prevented the MeCCl3-induced decrease in hexobarbital narcosis and the decrease in hepatic drug metabolism. (66-81-9 Cycloheximide)(50-76-0 Actinomycin D) Repeated injections of morphine or adrenalectomy did not block the action of MeCCl3. After 24 hr of MeCCl3 inhalation, the MeCCl3 concn. in liver was markedly greater than that in blood. 50-09-9; 57-53-4; 61-80-3; 58-15-1! 66-81-9! 50-76-0; 71-55-6 7112 HEEP/74/05563 GAMBERALE F HULTENGREN M Methylchloroform exposure: II. Psychophysiological functions. WORK-ENVIRON-HEALTH! 10 (2). 1973 82-92 WEHRB HEEP COPYRIGHT: BIOL ABS. The effect of the solvent methylchloroform on psychophysiological functions, such as reaction time, perceptual speed and manual dexterity, was studied in 12 healthy, male ' 000^^5 1,1,1-TRICHLOROETHANE PAGE 5 '"-J o CAS REGISTRY NUMBER ENTRY MONTH 7 SECONDARY SOURCE ID rh AUTHOR TITLE SJ>\ SOURCE w LANGUAGE ABSTRACT r'w*i' O o o - SL 030340 o* subjects. Each subject was repeatedly tested during exposure to 250 ppm, 350 ppm, ABO ppm and 550 ppm of methylchloroform in inspiratory air and under control conditions with exposure to pure air. Every other minute during the trials, samples were taken of subject alveolar air. Very high correlations were obtained for 2 subjects, and a linear relationship was noted between the concentrations in alveolar air and arterial blood. Subject reaction time. perceptual speed and manual dexterity were all impaired during exposure to methylchloroform as compared to exposure to pure air. Analyses of the results strongly suggest that psychophysiological functions in humans are unfavorably affected by an exposure to an average vapor concentration of 350 ppm. 71-55-6 7A07 HAPAB/70/00117 Gazzaniga BinaschiSSportelliARivaM G The elimination in the alveolar air in man of 1,1,1-trichloroethane following exposure to 600 ppm for 3 hours. Boll. Soc. Ital, Biol. Sper! A5(2>: 97-9, 1969 ITA HAPAB Prior studies have shown that man can safely tolerate a A50-ppm air concentration of 1,1,1-trichlorethane (methylchloroform) for 8 hr without developing psychosensory deficit. Six volunteers were exposed for 3 hr to 600 ppm of the compound in a special chamber! every 30 min, additional methylchloroform was added to the air to maintain the experimental exposure level. Monitoring was by gas chromatography with flame ionic detector. All the subjects tolerated the methylchloroform perfectly without manifesting either subjective or objective ( respiration and pulse frequencies or clinically certifiable changes ) effects. After the experiment, a sample of alveolar air was taken from each subject. The results are tabulated for periods of 1 min, A, 12, 2A, 28, A8 and 96 hr after the exposure. At A hr, a 50'/. reduction in the ppm concentration of 1, 1,1-trichloroethane was seen in alveolar air ( a range of A0 to 50 ppm ). At 12 hr, it was 20 ppm! at 2A hr, 10 ppm! at 96 hr, 1 ppm! less than 1 ppm o i- o o o o o o o o o 0 0 0 ; 000 ft 1,1>1-TRICH LOROETHANE PAGI 6 CAS REGISTRY NUMBER ENTRY MONTH S SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR TITLE SOURCE CODEN ABSTRACT SL 030341 1>1,1-trichloroethane was still detectable after 120 hr following exposure. The data permit the hypothesis that, independent of the type of halogenated hydrocarbon derivative ( carbon tetrachloride, trichloroethylene, etc. > at least 3 hr are needed for a 50Z drop in alveolar tension from initial value. It can also be hypothesised that, after exposure to a certain risk compatible with the psychosensory job requirements, a considerable quantity of the toxic substance remains in the workers after the work itself is finished and for a definite time thereafter. Such a residue, with probable organotropic concentration, could interfere with psychophysiological capacity at a level higher to that normally required, not to mention the possibility of drug or alcohol summation or potentiation effects. TOXICOLOGY AND PHARMACOLOGY 70/01/00, 32 1969 56-23-5. 71-55-6, 79-01-6 7312 HEEP/74/08996 HERD PA LIPSKY M MARTIN HF Cardiovascular effects of 1.1,1.-trichloroethane. ARCH ENVIRON HEALTH; 28 (4). 197A 227-233 A EH LA HEEP COPYRIGHT: BIOL ABS. Acute exposure of anesthetized dogs to 1,1,1,-trichlorethane (TCE) results in a dose-dependent, biphasic decline in arterial pressure similar to that observed following exposure to a commercial solvent containing TCE. The initial phase of pressure decline is associated with peripheral vasodilation whose magnitude exceeds concomitant, reflex, positive chronotropic and inotropic effects on myocardial function. The peripheral dilation could be reversed by injection of the alpha-agonist, phenylephrine hydrochloride. The 2nd phase of pressure decline is primarily associated with a depression of myocardial function; heart rate, stroke output and myocardial contractility declined. Injection of Ca-plus plus ameliorated the TCE-induced alteration of myocardial contractility and blood pressure was [ r\ f!-*S o n Q O rr CAS REGISTRY NUMBER ENTRY MONTH SECONDARY SOURCE ID AUTHOR AUTHOR TITLE SOURCE CODEN ABSTRACT CAS REGISTRY HUMBER ENTRY MONTH 1,1.1-TRICH LOROETHANE protected. Comprehension of the mechanismts) by which TCE induces cardiovascular depression may lead to more effective clinical management of the toxic effects of this compound. 71-55-6 7607 HEEP/75/12293 HERD PA MARTIN HF Effect of 1.1.1-trichloroethane on mitochondrial metabolism. BIOCHEM PHARMACOL; 26 (11-12). 1975 1179-1186 BCPCA HEEP COPYRIGHT: BIOL ABS. The effect of 1.1>1-trichloroethane (TCE) on rat liver (and heart) mitochondrial metabolism was assessed by studying the respiratory control characteristics associated with ATP synthesis from added ADP as well as low level Ca-2t uptake. With pyridine nucleotide-linked substrates there is a marked decline in State 3 (ADP) respiration (50X inhibition concentration = 0.65 mumol TCE/mg of mitochondrial protein). This respiratory inhibition was due to interruption of electron transfer at the rotenone-sensitive site on the electron transport chain. The ADP/0 ratio is largely unaffected. Succinate-linked State 3 (ADP) respiration is not inhibited by TCE (in this same concentration range), but there is an apparent uncoupling due to enhanced State 6 (ADP) respiration. This latter effect is due to the release of an ATPase activity dependent on exogenous Mg-2+. In the absence of exogenous Mg-2+> ATP synthesis and ATPase activity are largely unaffected by TCE. Studies on low level Ca-2+ uptake indicate that the halocarbon alters the passive permeability characteristics of the . mitochondrion to Ca-2* and H+. but the Ca-2+ binding and sequestration mechanisms are unaffected. The data provide a mechanistic basis for the previously described. TCE-induced depression of myocardial respiration and the alteration in myocardial contractility observed during acute exposure to this compound. 71-55-6 7507 O o o G O O o o G o 0 0 0 0 SL 030342 0 oooWffsa 1,1,1-TRICHLOROETHANE PAGE 6 10 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR TITLE SOURCE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 11 SECONDARY SOURCE ID AUTHOR TITLE SOURCE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH SL 030343 G HEEP/74/04721 HERD PA MARTIN HF UPSKY M CAROIO VASCULAR ALTERATIONS RESULTING FROM INHALATION OF I 1 1 TRICHLOROETHANE, TOXICOL APPL PHARMACOL1 5 (3). 1973 46S-469 TXAPA HEEP COPYRIGHT: BIOL ABS. ABSTRACT DOG TOXICOLOGY ORGANIC SOLVENT CATECHOLAMINES 71-55-6 7407 HEEP/74/09643 KAY RN Survey of toxic hazards during' vapor degreasing with trichloroethylene and 1,1, 1-tr1chloroethane. ANN OCCUP HYGI 16 (4). 1973 (RECD 1974) 417-419 AOHYA HEEP COPYRIGHT: BIOL ABS. Atomospheric sampling was carried out in the vicinity of vapor degreasing plant in 21 factories in the South and Midlands of England. Workers wore personal samplers to measure their average exposure over most of a working day and other atmospheric samples were taken at selected points around the degreasing tasks. Familiar problems were found at a number of tanks and of the 71 workers who wore personal samplers> 1/4 were receiving an average concentration of trichloroethylene in excess of the threshold limit value throughout their working day. Modern industry operates at an evei--increasing pace and many tanks are used to the limit of their capacity. The result is that short cuts may be taken and excessive quantities of trichloroethylene can enter the workroom air. Similar problems can exist with 1>1 *1-trichloroethane but> during the survey, concentrations of this solvent in the air were well below toxic levels during normal vapor degreasing. 71-55-6, 79-01-6 7407 $ $ 0 0 0 1. 000^^9 1,1,1-TRICHL0R0ETHANE PAGE 9 f~. w' o o o o c o o '-J SL 030344 12 SECONDARY SOURCE 10 AUTHOR AUTHOR ADDRESS TITLE SOURCE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH CA/010/004234H KLAASSEN CD PLAA GL COLL. OF MED., UNIV. OF IOWA, IOWA CITY, IOWA. COMPARISON OF THE BIOCHEMICAL ALTERATIONS ELICITED IN LIVERS FROM RATS TREATED WITH CARBON TETRACHLORIDE, CHLOROFORM, 1.1.2-TRICHLOROETHANE, AND 1,1,1 TRICHLOROETHANE BIOCHEM. PHARMACOL.; VOL 18, ISS 6, 1969,2019-27 BCPCA CBAC COPYRIGHT: CHEM ABS THE HEPATOTOXICITIES OF I.P. ADMINISTERED CHLOROHYDROCARBONS WERE COMPARED IN RATS. 156-23-53 CARBON TETRACHLORIDE PRODUCED THE HIGHEST INCREASE IN HEPATIC TRIGLYCERIDES AND ALSO PRODUCED ELEVATED LEVELS AT THE LOWEST DOSE 0.03 ML./KG.. [67-66-33 CHLOROFORM WAS INTERMEDIATE IN ELICITING ELEVATED LIVER TRIGLYCERIDE LEVELS C79-00-53 1.1.2-TRICHLOROETHANE ELEVATED TRIGLYCERIDES ONLY AT NEAR LETHAL DOSAGES 0.3 MG./KG.. SIGNIFICANT DOSE-RELATED DECREASES IN HEPATIC GLUCOSE 6-PHOSPHATASE ACTIVITY WERE SEEN WITH DOSES OF 0.3 ML. CARBON TETRACHLORIDE PER KG. OR GREATER NO SUCH DECREASE IN ENZYME ACTIVITY WAS DETECTED WITH THE OTHER CHLOROHYDROCARBONS. WHEN THE CHLOROHYDROCARBONS WERE ADDED DIRECTLY TO LIVER HOMOGENATES, ONLY THOSE INCUBATIONS CONTAINING CARBON TETRACHLORIDE SHOWED INCREASED LIPID PEROXIDATION. IN VIVO, CARBON TETRACHLORIDE INDUCED LIPID PEROXIDATION, AS INDICATED BY CONJUGATED DIENE LEVELS, WITHIN 15 MIN. THIS EFFECT ATTAINED A PEAK AT 30 MIN. INCREASED CONJUGATED DIENES WERE DETECTED WITH DOSES OF 0.3 ML. CARBON TETRACHLORIDE PER KG. OR GREATER. HOWEVER, WITH THE OTHER CHLOROHYDROCARBONS, NO INCREASE IN CONJUGATED DIENES WAS DETECTED. THUS, ALTHOUGH THE TEMPORAL RELATIONS OF CARBON TETRACHLORIDE-INDUCED HEPATOTOXICITY ARE COMPATIBLE WITH THE LIPID PEROXIDATION HYPOTHESIS, THE DOSAGE RELATION IS LESS CLEAR. FURTHER, THE LACK OF QUALITATIVE SIMILARITY IN THE RESULTS WITH CHLOROFORM DID NOT SUPPORT THE HYPOTHESIS. 56-23-55 67-66-35 79-00-5! 71-55-6 6912 00014040 1,1,1-TRICH LOROETHANE PAGE 10 0 $ 13 SECONDARY SOURCE ID AUTHOR AUTHOR ADDRESS TITLE SOURCE LANGUAGE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 14 SECONDARY SOURCE ID AUTHOR AUTHOR' AUTHOR TITLE SOURCE PUBLICATION TYPE LANGUAGE CODEN ABSTRACT KEYWORDS KEYWORDS KEYWORDS CA/013/004487E Lai H Shah HC Dep. Pharmacol. Toxicol.* Univ. Kansas* Lawrence * Kans. Effect of methylchloroform inhalation on barbiturate hypnosis and hepatic drug metabolism in male mice Toxicol. Appl. Pharmacol.; VOL 17* ISS 3* 1970,625-33 Eng TXAPA CBAC COPYRIGHT: CHEM ABS A 24-hr inhalation of methylchloroform tl) by male mice decreased hexobarbital Na til) (80 mg/kg)-induced hypnosis* the max. redn. occurring 4 hr after termination of inhalation, but had no effect on barbital Na (275 mg/kg i- or chloral hydrate (350 mg/kg)-induced hypnosis. (71-55-6 Methylchloroform)(50-09-9 Hexobarbital sodi uni )(144-02-5 Barbi tal sodi urn )( 302-17-0 Chloral hydrate) Repeated short exposures, 4 or 3 hr/day for several days* had a cumulative effect, but a single 8-hr exposure had no effect on II hypnosis in male mice. Microsomal drug-metabolizing enzymes in liver supernatant fractions (900 g) from mice previously exposed to I vapor oxidized II more efficiently* but the ability to reduce p-nitrobenzoic acid remained unaffected when compared with similar fractions from control mice. (62-23-7 p-Nitrobenzoic acid) 71-55-6! 50-09-9! 144-02-5! 302-17-0; 62-23-7 7112 ETIC/75/012663 LEONG 8KJ SCHWETZ BA GEHRING PJ EMBRYO- AND FETOTOXICITY OF INHALED TRICH L0R0ETHYLENE,PERCH LOROETHY LENE,METHY LCH LOROFORM AND METHYLENE CHLORIDE IN MICE AND RATS TOXICOL APPL PHARMACOL; 33:136,1975 Meeting Abstract ENG TXAPA ETIC/ORNL SEE: BI 76-6813 TRICHLOROETHYLENE PERCHLOROETHYLENE METHYLCHLOROFORM o o o 0 o 0 0 0 0 0 0 0 00014041 KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS CAS REGISTRY NUMBER ENTRY MONTH 15 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR AUTHOR TITLE SOURCE CODEN ABSTRACT --s"ft o o o o o o O SL 030346 1,1,1-TRICHLOROETH ANE PAGE 11 3 METHYLENE CHLORIDE MAMMAL MOUSE RAT MUS RATTUS VIABILITY, FERTILITY, AND MORTALITY NO ABNORMALITIES OBSERVED 79-01-65 127-18-4; 71-55-6; 75-09-2 8406 HEEP/75/12275 MCNUTT NS AMSTER RL MCCONNELL EE MORRIS F Hepatic lesions in nice after continuous inhalation exposure to 1,1,1-trichloroethane. LAB INVEST; 32 (5). 1975 642-654 LA INA HEEP COPYRIGHT: BIOL ABS. Male CF-1 nice (24-34 g) were exposed to either 250 ppm or 1000 ppm of 1,1,1-trichloroethane (a common industrial solvent) in air continuously for 14 wk. Control nice were exposed to room air. Serial sacrifice of exposed and control mice from 1-14 wk demonstrated signigicant changes in the centrilobular hepatocytes of animals in the 1000 ppm group. Moderate liver triglyceride accumulation was evident in the 1000 ppm group and peaked at 40 mg/g of tissue (wet weight) after 7 wk of exposure. Partial recovery was indicated by a decrease in the hepatic triglyceride level of 16 mg/g by 14 wk of exposure to 1000 ppm. Electron microscopic evaluation revealed that cytoplasmic alterations were most severe in centrilobular hepatocytes in the 1000 ppm group and were mild to minimal in the 250 ppm group. These alterations consisted of vesiculation of the rough endoplasmic reticulum, with loss of attached polyribosomes, increased smooth endoplasmic reticulum, microbodies, and triglyceride droplets. Some cells had ballooned cisternae of the rough endoplasmic reticulum. Necrosis of individual hepatocytes occurred in 40X of the mice exposed to 1000 ppm for 12 wk. This necrosis was associated with an acute inflammatory infiltrate and hypertrophy of Kupffer cells. Comparison of these findings to the results obtained by other Investigators studying dichloromethane o o o o o o o 3 O o o o o C'i 00014042 1.1,1-TRICHLOROETHANE PAGE 12 CAS REGISTRY NUMBER ENTRY MONTH 16 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE CODEN ABSTRACT si. indicates that the pathologic alterations observed i4i th 1,1,1-trichloroethane were similar to those observed with dichiorowethanet except for different time courses of the effects and different degrees of recovery. The toxic effects of 1>1,1-trichloroethane were of a type similar to those produced by CC14, but they appeared to be much less severe. 71-55-6 7507 CA/006/001209K PRENDERGAST JA JONES RA JENKINS LJ JR SIEGEL J NATL. NAVAL MED. CENTER, BETHESOA, HD. EFFECTS ON EXPERIMENTAL ANIMALS OF LONG-TERM INHALATION OF TRICHLOROETHYLENE, CARBON TETRACHLORIDE, 1,1,1-TRICHLOROETHANE DICHLORODIFLUOROMETHANE, AND 1,1-DICHLOROETHYLENE TOXICOL. APPL. PHARMACOL.! VOL 10, ISS 2, 1967,270-89 TXAPA CBAC COPYRIGHT: CHEM ABS RATS, GUINEA PIGS, SQUIRREL MONKEYS, RABBITS, AND DOGS WERE EXPOSED TO THE INHALATION OF 175-71-83 DICHLORODIFLUOROMETHANE, [56-23-53 CARBON TETRACHLORIDE, [79-01-63 TRICHLOROETHYLENE, [71-55-63 1,1,1-TRICHLOROETHANE, OR [75-35-43 1,1-DICHLOROETHYLENE CONTINUOUSLY FOR 90 DAYS TO SIMULATE SUBMARINE CONDITIONS OR FOR 8 HRS., 5 DAYS A WEEK, OVER A PERIOD OF 6 WEEKS TO SIMULATE INDUSTRIAL EXPOSURE. OVER A PERIOD OF ALMOST 4 YEARS, NO SYMPTOMS OF TOXICITY WERE SEEN IN ANY OF THE SPECIES EXPOSED TO THESE MATERIALS HOWEVER, MORTALITY HAS SIGNIFICANTLY INCREASED IN ANIMALS EITHER REPEATEDLY OR CONTINUOUSLY EXPOSED TO CARBON TETRACHLORIDE AT RESPECTIVE CONCENTRATIONS OF 515 AND 61 MG./M.3, AND ALSO IN THOSE CONTINUOUSLY EXPOSED TO 1,1-DICHLOROETHYLENE AT 189, 101, AND 61 MG./M3. GROWTH WAS DEPRESSED IN ALL CONTINUOUS EXPOSURES TO TRICHLOROETHYLENE, CARBON TETRACHLORIDE, AND 1,1-DICHLOROETHYLENE AND IN REPEATED EXPOSURES TO CARBON TETRACHLORIDE. THROUGHOUT THE STUDY NO SIGNIFICANT CHANGES WERE SEEN IN THE NUMBER OF LEUKOCYTES, AMOUNT OF HEMOGLOBIN, OR HEMATOCRIT VALUES. CARBON TETRACHLORIDE, 1,1-DICHLOROETHYLENE, AND ) 00014043 1,1,1-TRICHLOROETHANE 9 PAGE 13 O Q j- \ w V) CAS REGISTRY NUMBER ENTRY MONTH 1.1.1-TRICHLOROETHANE DID NOT SIGNIFICANTLY AFFECT BLOOD SERUM [57-13-61 UREA NITROGEN LEVELS. REPEATED EXPOSURE TO CARBON TETRACHLORIDE SIGNIFICANTLY INCREASED LIVER LIPIDS IN GUINEA PIGS. FOLLOWING THE CONTINUOUS EXPOSURE OF RATS AND GUINEA PIGS TO 184 MG./M.3, OF 1,1-DICHLOROETHYLENE, SERUM GLUTAMIC-PYRUVIC TRANSAMINASE AND HEPATIC ALKALINE PHOSPHATASE ACTIVITIES WERE SIGNIFICANTLY ELEVATED. THE EFFECTS OF TRICHLOROETHYLENE AND DICHLORODIFLUOROMETHANE ON BIOCHEMICAL PARAMETERS WERE NOT STUDIED. THE LIVER WAS DAMAGED BY CONTINUOUS EXPOSURES TO DICHLORODIFLUOROMETHANE 3997 MG./M.3, CARBON TETRACHLORIDE 61 MG./M.3, AND 1.1- DICHLOROETHYLENE 189 MG./N.3. REPEATED EXPOSURES TO CARBON TETRACHLORIDE AND 1,1-DICHLOROETHYLENE 395 MG./M.3 SIMILARLY DAMAGED THE LIVER. 75-71-8! 56-23-5; 79-01-6; 71-55-6; 75-35-4i 57-13-6 6712 ri fi Q Q 17 SECONDARY SOURCE ID AUTHOR HEEP/76/00936 SALVINI M o TITLE PSYCHOLOGICAL EFFECTS OF TRICHLOROETHYLENE AND 111 TRICHLOROETHANE UPON MAN. O SOURCE XINTARAS, CHARLES, BARRY L. JOHNSON AND IDO DE GROOT (ED.). BEHAVIORAL TOXICOLOGY. EARLY o DETECTION OF OCCUPATIONAL HAZARDS. WORKSHOP, CINCINNATI, OHIO, U.S.A., JUNE 24-29, 1973. IX+507P. ILLUS. U.S. DEPARTMENT OF HEALTH, o EDUCATION AND WELFARE, NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH, CINCINNATI, o COOEN ABSTRACT OHIO, U.S.A.*, 1974 (RECD 1975) 92-95 04305 HEEP COPYRIGHT: BIOL ABS. o CAS REGISTRY NUMBER 71-55-6; 79-01-6 ENTRY MONTH 7607 Q ia SECONDARY SOURCE ID CA/076/054922Q a AUTHOR Salvini M AUTHOR Binaschi S AUTHOR ADDRESS Riva M Inst. Prevent. Med. Work. Appl. Psychol., o Univ. Pavia, Pavia, Italy TITLE Evaluation of the psychophysiological functions in humans exposed to the threshold limit value of 1,1,1-tri chloroethane o SOURCE Brit. J. Ind. Med.*, VOL 28, ISS 3, 1971,286-92 LANGUAGE Eng CODEN ABSTRACT BJIMA CBAC COPYRIGHT: CHEM ABS The daily exposure o 03 a ta 'J o o Q U Q (gl 00014045 1.1,1-TRICHLOROETHANE PAGE 15 O t* CAS REGISTRY NUMBER ENTRY MONTH in the liver, kidneys, myocardium, and lungs were obsd. 71-55-6; 9031-66-7 7312 *### END OF OFFLINE PRINT #* ^ Cl Cl Cl Cl (J a y y e ci 030350 SL y y # *****KK*KK**Wtt******KttK***tttt*K********ttKK***KWK*******K****KKKKft*PK0K0K931K58* ** * THIS IS AN OFF-LINE BIBLIOGRAPHIC CITATION LIST GENERATED BY * ** * MEDLARS II * ** * N.L.M.'S NATIONAL INTERACTIVE RETRIEVAL SERVICE * ** ** 1.1.I-TRICHLOROETHANE NUMBER OF CITATIONS PRINTED = 38 THIS SEARCH WAS PERFORMED ON THE T0XBACK76 MAY 20, 1986 FILE. SORT = tELEMENTS/OIRECTIONS GIVEN BY USER) WAS SPECIFIED PLEASE SEND THIS LISTING TO m # DIANA DANKO / PPG INDUSTRIES,INC P.O. BOX 31 m BARBERTON, OHIO 99203 SL 030351 00013965 1,1,1-TRICHLOROETHANE PAGE 1 1 SECONDARY SOURCE ID ADDRESS TITLE SOURCE LANGUAGE CODEN ABSTRACT CAS REGISTRY NUMBER DATA TAG ENTRY MONTH Z SECONDARY SOURCE ID ADDRESS TITLE SOURCE LANGUAGE CODEN ABSTRACT SL 030352 CA/086/18A339X Bethesda, Md. Bioassay of 1,1,1-trichloroethane for possible carcinogenicity Carcinog. Tech. Rep. Ser. - Natl. Cancer Inst. tU. S.); ISS NCI-CG-TR-3,, 1977,70 pp. ENG CTRID CBAC COPYRIGHT: c'HEM ABS Rats given 1500 and 750 mg/kg/day doses of 1.1.1- trichloroethane (I) orally from 7 to 117 weeks of age developed nasal discharge, wheezing, urine staining on abdominal fur, and a hunched appearance. (71-55-6 1.1.1- Trichloroethane) Mice given A000 and 000 mg/kg/day oral doses of I from 5 to 10 weeks of age, 5000 and 500 mgAg/day doses until week E0, and 6000 and 3000 mg/kg/day doses to 96 weeks of age showed moderate decreases in wt. gain and decreased survival. The neoplasms obsd. at the end of treatment were not attributed to I, as no relation was obsd. between dosage, species, sex, neoplasm type, or site of occurrence. 71-55-6 CHRONIC TOXIC DOSE 7707 CA/087/205S61Z Cincinnati, Ohio Criteria for a recommended standard-occupational exposure to 1, 1, 1-trichloroethane (methyl chloroform) U. S. NTIS, PB Rep.*, ISS PB-E67069,, 1976,191 pp. ENG XPBRC CBAC COPYRIGHT: CHEM ABS Recommendations are presented for an occupational exposure std. for 1,1,1-trichloroethane in workroom air and medical surveillance, labeling, posting, personal protective equipment and clothing, informing workers of hazards, work practices, monitoring, and recordkeeping are described. (71-55-6 1,1,1-trichloroethane) Biol, effects of exposure are reviewed, including historical reports, effects on humans, epidemiology, animal toxicity, and correlation of exposure and effect. Environmental concns., engineering controls, environmental sampling, analytical methods, the biol. evaluation of exposure, and the 00013966 1,1.1-TRICH LOR0ETHANE PAGE Z CAS REGISTRY NUMBER ENTRY MONTH 3 SECONDARY SOURCE ID ADDRESS TITLE SOURCE LANGUAGE CODEN ABSTRACT m CAS REGISTRY NUMBER ENTRY MONTH A SECONDARY SOURCE ID ADDRESS m TITLE SOURCE LANGUAGE CODEN ABSTRACT SL 030353 development of the std. are discussed. 71-55-6 7802 CA/068/197009F Columbus, Ohio Environmental monitoring near industrial sites. Hsthylchlorofoi'm U. 3. NTIS, PB Rep., ISS RB-27320A,, 1977,82 pp. ENG XPBRC CBAC COPYRIGHT: CHEM ABS The levels of methylchloroform in various environmental media uere detd. in air, water, soil, end sediments of A prodn. sites, 1 user site, and a background site. (71-55-6 Methylchloroform) Considerable variation was obsd. in the max. downwind levels at various prodn. plants. Concns. in ambient air ranged from <0.3 to 155 ppb. Concns. in surface water in the vicinity of prodn. and user plants was even more variable ranging from fractions of a ppb to >16 ppm. Concns. in soil and sediment range from the limits of detection to >6.1 ppm. 71-55-6; 7732-18-5 7807 CA/090/075839X Columbus, Ohio Multimedia levels - methylchloroform Report; ISS EPA/560/6-77/030! Order No. PB-281892>, 1977,50 pp. ENG D8REP CBAC COPYRIGHT: CHEM ABS The concns. of MeCC13 (I) in the US atm. ranges from apprx.0.1 mug/m3 (20 ppt 1 in remote areas to >500 mug/m3 (100 ppb) in some areas near where the substance is manufd. or used. (71-55-6 Methylchloroform) The concn. drops off rapidly as one moves away from a source facility. Surface water contamination of ranges from <1 ppb to several hundred ppb In the vicinity of I manufacturers. The highest measurement reported (3 ppm) was made in a roadside ditch near a producer site. I has been detected but not quantified in US drinking water except in one case when approx. 10 ppb was reported. Soil and sediment concns. appear to be no higher near manufacturers and users than in rural areas, m * (J 00013967 1,1,1-TRICHLOROETHANE PAGE 3 l rt i 'wr O, o 0 0 [ 0 CAS REGISTRY NUMBER ENTRY MONTH 5 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE LANGUAGE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH though the dataars very Limited. -The levels are or the order of fractions of a ppb. I Is relatively stable in the atm.I however, the mol. is susceptible to hydrolysis or dehydrohalogenation and reacts with water relatively rapidly and is thus degraded in soil and water. There are very few data on press-.!/: of I in food raised and sold in the US. However, data from the United Kingdom suggest that I is found on the order of ppb in some common foodstuffs. There is little evidence to judge whether I accumulates In living organisms. Limited data on levels in marine organisms show levels on the order of a few ppb. 71-55-6 7903 CA/086/184099K Ando K Hayashi M Kosaka H Tabuchi T Osaka Public Health Inst., Osaka. Japan Toxicological studies of methylchloroform. II. Distribution of methylchloroform in rats Osaka-furitsu Koshu Eisei Kenkyusho Kenkyu Hokoku, Rodo Eisei Hen* VOL 15,, 1977,23-6 JPN OFKIA CBAC COPYRIGHT: CHEM ABS The max. concn. of methylchloroform in expired air following the i.p. injection of MeCC13 into rats at 200 mg/kg was obsd. at 10-20 min and decreased thereafter with a half-life of 60 min. (71-55-6 Methylchloroform) The total amt. excreted by respiration was about 90X of the given dose in 8 h. MeCC13 concn. in fat tissues was highest and the decrease of the concn. extremely slow; the concn. was >10 times that in other tissues such as the liver , kidney, spleen , and central nervous system. 71-55-6 7807 # -- 03035'' m 9 0 a y> o I# i T* 00013968 1t1,1-TRICHLOROETHANE PAGE A SECONDARY SOURCE ID AUTHOR ADDRESS TITLE SOURCE LANGUAGE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH SECONDARY SOURCE ID AUTHOR TITLE SOURCE PUBLICATION TYPE LANGUAGE CODEN ABSTRACT KEYWORDS CAS REGISTRY NUMBER ENTRY MONTH SECONDARY SOURCE ID AUTHOR TITLE SOURCE PUBLICATION TYPE LANGUAGE CODEN ABSTRACT KEYWORDS CAS REGISTRY NUMBER ENTRY MONTH CA/088/126246V Anon Food Drug Adm., Rockville, Md. Trichloroethanei status as a new drug In aerosolized drug products intended for inhalation Fed. Regist.I VOL 42, ISS 242, 1977,63386-7 ENG FEREA CBAC COPYRIGHT: CHEM ABS Deaths have resulted from abuse or gross misuse of aerosol decongestant products intended to be inhaled and contg. 1,1,1-trichloroethane tl). (71-55-6 1,1,1-Trichloroethane) Marketing any aerosol drug product contg. I intended to be inhaled directly or indirectly will require an approved new drug application under the Federal Food, Drug, and Cosmetic Act. 71-55-6 7805 ETIC/79/008469 ANONYMOUS 1.1.1-TRICH LOROETHANE I A R C MONOG EVAL CARCINOGENIC RISK CHEM HUMANS! 20:515-531,1979 Journal Article ENG IMEMD ETIC/ORNL 1.1.1-TRICHLOROETHANE 71-55-6 8406 EMIC/79/011624 ANONYMOUS 1,1,1-TRICHLOROETHANE IARCtINT AGENCY RES CANCER1MONOGRi 20=515-531,1979 Journal Article ENG IARMB EMIC/ORNL 1,1,1-TRICHLOROETHANE 71-55-6 8406 030355 SL r*! 00013969 1,1,1-TRICH LOR0ETHANE PAGE 5 a O ii 9 SECONDARY SOURCE ID PESTAB/80/1456 O AUTHOR Anonymous TITLE 1>1,1-Trichloroethane. SOURCE CODEN IARC Moncgr. 20: 515-531 1979 (61 References) XXXXX o ABSTRACT PESTAB. Synonyms and trade names, structural and molecular formulae and molecular weight, chemical and physical properties, technical products and of 1,1,1-trichloroethane are o given. The chemical is used in the US in insecticide formulations. It is approved by the US FDA for use in packaging, transporting or holding food. This chemical is exempted o from the requirement of a tolerance for residues when it is used as a solvent in \ pesticide formulations applied to growing o crops and raw agricultural commodities after harvest and when it is used in the post-harvest fumigation of citrus fruits. It is also exempt from residue tolerance limits when used as a solvent in pesticide o formulations to be used on animals, when it comprises not more than 25X of the r~, formulation. Findings of carcinogenicity, o embryotoxicity and teratogenicity studies are reviewed. Available data do not permit an evaluation to be made of the carcinogenicity o CAS REGISTRY NUMBER of 1,1,1-trichloroethane. 71-55-6 ENTRY MONTH 8005 o SECONDARY SOURCE ID AUTHOR CA/090/0345Q3Q Apostol I ADDRESS Orsz. Munka Uzemegeszsegugyi Inter., Budapest, Hung. o TITLE Toxicology of methyl chloroform (1,1,1-trichloroethane) used as a carbon tetrachloride substitute SOURCE MunkavedelemS VOL 24, ISS 4-6, 1978,33-5 LANGUAGE CODEN HUN MUNKA ABSTRACT CBAC COPYRIGHT: CHEM ABS A review with 21 refs, on the metab. and toxicol. of 1,1,1-trichloroethane. (71-55-6 1,1iI-Trichloroethane) Tolerance values are given. CAS REGISTRY NUMBER 71-55-6 ENTRY MONTH 7902 SL 030356 # i ! ti 1 00013970 o 1,1.1-TRICHLOROETHANE PAGE 6 SECONDARY SOURCE ID HEEP/76/12474 AUTHOR CAPLAN YH AUTHOR BACKER RC Q AUTHOR ADDPESS WHITAKER JQ Off. Chief Med. Exam.) State Md.i Baltimore> Md. USA. TITLE l>ltl-Trichloroethane: Report of a fatal O SOURCE intoxication. CLIN TOXICOL! 9(1). 1976 69-74 CODEN CTOXA ABSTRACT HEEP COPYRIGHT: BIOL ABS. o 1 tit 1-Trichloroethane (TCE) uias indicated in the accidental death of a woman cleaning up a paint spill in an enclosed> poorly ventilated room. Blood and tissue concentrations of TCE o were measured by head-space gas chromatography. The concentrations found were compared with previously reported concentrations concluding that the o demonstrable presence of TCE In blood at a concentration above 1.0 to 1.5 mg/100 ml would be consistent with death. However) the rapid dissipation of TCE from blood dictates Q that its presence in post mortem samples at any concentration must be considered as a factor in determining the cause of death. CAS REGISTRY NUMBER 71-55-6 ENTRY MONTH 7607 SECONDARY SOURCE ID HEEP/78/06226 AUTHOR CORREIA Y AUTHOR MARTENS GJ AUTHOR VAN MENSCH FH AUTHOR NHIM BP ADDRESS Rhone Poulenc Petrochem.t St. Auban, Fr. TITLE The occurrence of trichloroethylene) tetrachloroethylene and l)l>l-trichloroethane in western Europe in air and water. SOURCE ATMOS ENVIRON! 11 (11). 1977 1113-1116 o CODEN ABSTRACT ATENB HEEP COPYRIGHT: BIOL ABS. Analyses were made of the concentration of trichloroethylene) tetrachloroethylene and u l)l>l-trichloroethane in the atmosphere in a number of western European countries. Typical concentrations range 0.1-3 ppb. Analyses of these same compounds in river( sea and canal a waters show a wider range of values dependent on the source of the halocarbon. The analyses were carried out over the period 1972-1976. CAS REGISTRY NUMBER 127-16-4; 79-01-6; 71-55-6 ENTRY MONTH 7807 SL 030357 030358 00013971 1,1,1-TRICHLOROETHANE PAGE 7 SECONDARY SOURCE ID AUTHOR ADDRESS TITLE SOURCE LANGUAGE CODEN ABSTRACT .) CAS REGISTRY NUMBER ENTRY MONTH 14 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR ADDRESS TITLE O SOURCE LANGUAGE o CODEN ABSTRACT o Q CA/094/1445B6M Cronn DR Washington State Univ., Pullman Measurements of atmospheric methylchloroform by Washington State University U. S. Environ. Prot. Agency* Off. Res. Dev., [Rep.3 EPA; ISS EPA-600/9-80-003, Proc. Conf. Methvi Chloroform Other Halocarbon Pollut.,, 1980,6/1-6/11 ENG XPARD CBAC COPYRIGHT: CHEM ABS The vertical and latitudinal distribution and time trends of MeCCL3 were detd. (71-55-6 1.1.1-Trichloroethane) The mixing ratio of MeCCl3 increases by >12X/yr at the tropopause. The concn. of MeCC13 was (av.) 97 and 115 parts per.trillion at 9.degree. N and 37.degree. N, resp. 71-55-61 10028-15-6 6105 CA/085/051136M Dilling WL Bredeweg CJ Tefertiller NB Dow Chem. Co., Midland, Mich. Organic photochemistry. XIII. Simulated atmospheric photodecomposition rates of methylene chloride, 1,1,1-trichioroethane, trichloroethylene, tetrachloroethylene, and other compounds Environ. Sci. Technol.j VOL 10, ISS 4, 1976,351-6 ENG ESTHA CBAC COPYRIGHT: CHEM ABS The photodecompn. rates of 33 chloroorg. compds. were detd. under simulated atm. conditions in presence of NO. In presence of NO, vinylidene chloride, cis-dichloroethylene, trans-dichloroethylene, trichloroethylene, and vinyl chloride decompd. at moderate rates (estd. half-life 5-12 hr under bright sunlight), as compared to 20-40 hr for PhCl, tetrachloroethylene, and 1.1.2-trichloroethane and >250 hr for CH2C12 and 1,1,1-trichloroethane. (75-35-4 Vinylidene chloride)(156-59-2 cis-Dichloroethylene)(156-60-5 trans-Dichloroethylene)( 79-01-6 Trichloroethylene)(75-01-4 Vinyl 00013972 1,1,1-TRICHL0R0ETHANE PAGE 8 o O o o o O 030359 o CAS REGISTRY NUMBER ENTRY MONTH 15 SECONDARY SOURCE 10 AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE CODEN ABSTRACT chloride)!25321-22-6 Dichlorobenzene)(127-18-4 Tetrachloroethylene)( 79-00-5 1,112-Trichloroethane )(75-09-2 Methylene chlorideK71-55-6 1,1i1-Trichloroethane) The photodecompn. rates of these chloro compds. were detd. in mixts. with other org. compds. and also in the presence of N02, 03, CC13CHO, AcH, Cl, and C0C12. (75-87-6 ChloralK75-07-0 Acetaldehyde) 75-35-4! 156-59-2! 156-60-5! 79-01-6! 75-01-4! 25321-22-6! 127-18-4! 79-00-5! 75-09-2! 71-55-6! 75-87-6! 75-07-0! 110-88-3! 96-54-8! 75-65-0! 107-96-2! 78-83-1; 107-39-1! 108-10-1! 10102-43-9! 106-89-8! 10102-44-0! 106-88-7! 10028-15-6! 78-93-3! 7782-50-5! 78-92-2! 71-36-3! 624-64-6! . 75-44-5! 75-52-5! 110-62-7! 110-83-8! 123-91-1! 108-88-3! 106-42-3! 108-38-3! 100-41-4 7612 HEEP/77/05661 EGLE J L JR LONG JE SIMON GS BORZELLECA JF Dep. Pharmacol., Med. Coll. Va., Va. Commonw. Univ., Richmond, Va. 23298, USA. An evaluation of the cardiac sensitizing potential of a fabric protector in aerosol form, containing 1,1,1-trichloroethane. TOXICOL APPL PHARMACOL! 38 (2). 1976 369-377 TXAPA KEEP COPYRIGHT! BIOL ABS. The cardiac sensitizing potential of Scotchgard Brand Fabric Protector FC-4101 (which contains 1,1,1-trichloroethane (TCE)) was assessed under simulated misuse conditions (e.g., use of the product in small, poorly ventilated areas). Beagle dogs were prepared for telemetric monitoring of their ECG and placed in a 290 1 chamber. They were observed for possible effects of inhalation exposure to FC-4101, alone or in combination with i.v. epinephrine (8 and 16 mug/kg) and/or stress induced by a 2 s blast from an air horn. The effects of inhaled pure TCE with Freon 12 propellant were also investigated. Changes in heart rate consisted of a bradycardia (presumably of reflex origin) due to epinephrine and stress, and a mild tachycardia following exposure to FC-4101 m m # % % '& u 00015973 1,1,1-TRICHLOROETHANE PAGE 9 CAS REGISTRY NUMBER ENTRY MONTH G 16 SECONDARY SOURCE. ID AUTHOR Author O AUTHOR TITLE e SOURCE PUBLICATION TYPE LANGUAGE CODEN ABSTRACT # SL 030360 producing a concentration of 5000 ppm TCE in air. Following exposure to FC-9101 producing a concentration of 10000 ppm TCE in air and following exposure to concentrations of 5000 ppm TCE in air and lOiOOO ppm TCE in air with Freon 12 propellant, no tachycardia occurred. Inhalation of FC-9101 did not act synergistically with exogenous epinephrine (8 mug/kg) or endogenous epinephrine released in response to stress to induce cardiac arrhythmias. The arrhythmias induced by 16 mug/kg of epinephrine and stress were not intensified by the concurrent inhalation of FC-9101, 5000 ppm TCE. With simulated misuse conditionsi FC-9101 and pure TCE with Freon IE propellant did not cause cardiac sensitization. 71-55-6; 51-93-9 7707 ETIC/79/007250 ELOVAARA E HEMMINKI K VAINIO H EFFECTS OF METHYLENE CHLORIDEtTRICHLOROETHANEiTRICHLOROETHYLENE,TETRACHLOROETHYLENE AND TOLUENE ON THE DEVELOPMENT OF CHICK EMBRYOS TOXICOLOGY; 12:111-119,1979 Journal Article ENG TXCYA ETIC/ORNL TOLUENE AND 5 ALIPHATIC CHLORINATED HYDROCARBONS OF WIDE INDUSTRIAL USE MERE INJECTED INTO THE AIR SPACE OF FERTILIZED CHICKEN EGGS AT 2,3 AND 6 DAYS OF INCUBATION.THE EMBRYOTOXICITY WAS EVALUATED AS SURVIVAL AND DEATH INCIDENCES AFTER 19 DAYS OF INCUBATION,AND ALSO THE WEIGHTS AND LENGTHS OF THE EMBRYOS WERE RECORDED.THE APPROXIMATE L050 VALUE FOR TRICHLOROETHYLENE AND TRICHLOROETHANES VARIED BETWEEN 50 AND 100 UMOL/EGG WHILE FOR TOLUENE,TETRACHLOROETHYLENE AND METHYLENE CHLORIDE IT HAS OVER 100 UMOL/EGG.MACROSCOPIC MALFORMATIONS OF VARIOUS KINDS WERE PRODUCED WITH DOSES OF 5-100 UMOL/EGG.THE TERATOGENIC POTENTIAL OF THE TESTED COMPOUNDS DECREASED IN THE FOLLOWING ORDER:1,1,1-TRICHLOROETHANE>TRICHLOROETHYLENE>METHYLENE CHLORIDE,TETRACHLOROETHYLENE,1,1,2-TRICHLOROE TH ANE>TOLUENE>0LIVE OIL CONTROL. # 00013979 o 1,1,1-TRICH L0R0ETHANE PAGE 10 KEYWORDS KEYWORDS KEYWORDS J KEYWORDS KEYWORDS KEYWORDS KEYWORDS 'J KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS O KEYWORDS KEYWORDS KEYWORDS KEYWORDS CAS REGISTRY NUMBER ENTRY MONTH 17 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE o SOURCE LANGUAGE CODEN ABSTRACT SL 030361 CAS REGISTRY NUMBER ENTRY MONTH 18 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR ADDRESS TITLE METHYLENE CHLORIDE 1.1.1-TRICHLOROETHANE 1.1.2-TRICH LOROETHANE TETRACHLOROETHYLENE TRICHLOROETHYLENE TOLUENE AVES CHICKEN GALLUS DOMESTICUS' WHITE LEGHORN SK 12 VIABILITY, FERTILITY, AND MORTALITY GROWTH SENSE ORGANS HOMEOSTASIS MUSCULOSKELETAL SYSTEM NERVOUS SYSTEM HEMIC AND LYMPHATIC SYSTEMS CRANIUM AND FACE SKIN AND SKIN APPENDAGES 75-09-2*, 71-55-6! 79-00-5! 127-18-9; 108-88-3 8906 79-01-6! CA/087/112568U Fukabori S Nakaaki K Yonemoto J Tada 0 Inst. Sci. Labor, Tokyo, Japan Cutaneous absorption of 1,1>l-trichloroethane. II Rodo Kagaku! VOL 53, ISS 1, 1977,89-95 ENG ROKAA CBAC COPYRIGHT: CHEM ABS After application of 1,1,1-trichloroethane (I) (2 h/day ) for 3 days to the forearm skin, the blood content of I reached 3-9 mug/mL and the alveolar air contained 2-7 ppm I immediately after the last applicat ion. (71-55-6 1,1,1-Trichloroethane> Repeated applications increased the concns. 71-55-6 7712 HEEP/79/06350 GILBERT J STARTIN JR WALLWORK MA Food Sci. Div., Minist. Agric. Fish. Food, Haldin House, Queen St., Norwich NR2 9SX, Norfolk, Engl., UK. Gas chromatographic determination of o o SL 030362 00013975 1,1,1-TRICHLOROETHANE PAGE 11 SOURCE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH SECONDARY SOURCE 10 AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE LANGUAGE COOEN ABSTRACT CAS REGISTRY NUMBER DATA TAG ENTRY MONTH 1,1,1-trichloroethane in vinyl chloride polymers and in -foods. J CHROMATOGRJ 160 tl). 1978. 127-132. jtr.r'i HEEP COPYRIGHT: BIOL ABS. A gas chromatographic method is described for the quantification of levels of 1il>l-trichloroethane In vinyl chloride polymer resins and in polyivinyl chloride) CPVC) bottles used in the packaging of foods. By application of electron-capture detection the method can be extended to foods which were stored in PVC bottles and 1,1,1-trichloroethane can be estimated with a limit of detection in the foodstuff of between 0.002-0.01 ppm, depending on the food. The results of a small survey of the amounts of this compound in PVC bottles and foodstuffs purchased from retail outlets are reported. 9002-86-2; 71-55-6 7908 CA/088/183980D Hayashi M Ando K Kosaka H Osaka Public Health Inst.. Osaka, Japan Toxicological studies of methylchloroform. 1. Determination of methylchloroform in biological materials Osaka-furi tsu Koshu Eisei Kenkyusho Kenkyu Hokoku, Rodo Eisei Heni VOL 15,, 1977,19-22 JPN 0FKIA CBAC COPYRIGHT: CHEM ABS More than 90* of methylchloroform in expired air of lab. animals was absorbed by hexane, and about 80* of MeCCl3 was recovered from various tissues. except fat tissues. 171-55-6 methylchloroform) The anal, of MeCCl3 in the ext. was carried out by gas chroraatog. with QF1 as stationary phase; the column temp, was 70.degree.. The detection limit was 10-8 g/mL. 71-55-6 BLOOD CONCENTRATIONS 7807 y j \ , j ^ ^ U UH o 00013976 1,1,1-TRICHLOROETHANE PAGE 12 0303&3 Sl> 20 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE CODEN ABSTRACT HEEP/81/08199 HENSCHLER D REICHERT D METZLER M Inst. Pharraakol. Toxikol., Univ., Versbacher Str. 9, D-8700 Wuerzburg, N. Ger. Identification of potential carcinogens in tech 'al grade 1,1,1-trichioroethane. INT ARCH OCCUP ENVIRON HEALTH; 47 (3). 1980 (RECD. 1981). 263-268. IAOHO HEEP COPYRIGHT: BIOL ABS. Gas chromatography and gas chromatography-mass spectrometry were used to analyze 22 samples of technical grade 1,1>1-tichloroethane for impurities! 18 contained vinylidene chloride (1,1-dichloroethylene) 130-900 mug/ral). Further contaminants were identified as 1.1-dichloroethane (11), trichloroethylene (12) and 1,1,2-trichloroethane (9). Nitromethane (18), 1,2-epoxybutane (19), t-butanol (7) and dioxane (10) were detected as stabilizers. Manufacturers should eliminate vinylidene chloride and stabilizers which carry a carcinogenic and/or mutagenic risk to humans from technical samples of 1.1.1-trichloroethane . 123-91-1; 106-88-7; 75-65-0; 75-52-5; 75-35-4; 71-55-6 8107 HEEP/77/11738 HOLMBERG BO JAKOBSON I SIGVARDSSON K Arbetarskyddsstyrelsen, Arbetsmed. Avdl., Fack, S-100 26 Stockholm 34, Swed. A study on the distribution of methylchloroform and n-octane in the mouse during and after inhalation. SCAND J WORK ENVIRON HEALTH; 3 (D. 1977 43-52 SHE HD HEEP COPYRIGHT: BIOL ABS. Distribution of methylchloroform and n-octane, respectively, in the blood, liver, kidney and brain of mice was studied at different inspired air concentrations and after different exposure times. The air concentration varied between 10-10,000 ppm; and the exposure time, between 0.5-24 h. The resulting solvent concentrations in kidney and brain were about the same, but liver concentrations were 00013977 1,1,1-TRICH LOROETHANE PAGE 13 ?\ o o o o o o a o o fSV 6` o CAS REGISTRY NUMBER ENTRY MONTH SECONDARY SOURCE ID AUTHOR AUTHOR ADDRESS TITLE SOURCE LANGUAGE usually somewhat higher for both solvents. There was a linear dependence between inspired air concentration and tissue concentrations at fixed exposure times. A correlation between blood and organ concentrations was observed in animals exposed at different inhalation air concentrations but not in animals exposed only at one fixed concentration. Ratios between the concentrations of the solvents in the organs and blood were higher for n-octane than for methylchloroform. The ratios increased as the exposure concentration increased for all organs studied in the case of n-octane but only for the liver in the case of methylchloroform. When the exposure dose, i.e.t inspired air concentrationerated in different ways, a high concentration during a short exposure resulted in a 10 times higher organ concentration than a low concentration during a long exposure. Liver, kidney and brain concentrations generally did not differ more than twice between methylchloroform and n-octane after exposure of the same concentration and duration. The blood concentration, however, was much less in n-oetane exposed animals than in methylchloroform exposed ones. A pharmacokinetic model with both uptake and elimination of the first order fitted the empirical data better for methylchloroform than a model with zero order uptake and first order elimination. Postexposure concentrations of methylchloroform were linear in a semi log graph. A 1-compartment pharmacokinetic model was in accordance with the experimental data for methylchloroform. For n-octane, however, at least a 2-compartment model must be assumed. 111-65-9; 71-55-6 7712 CA/087/162391B Humbert BE Fernandez JG Lab. Hyg. Ind., Univ, Neuchatel, Neuchatel, Switz. Exposure to 1*1,1-trichloroethane. Study of the absorption, excretion and metabolism by human subjects Arch. Mai. Prof. Med. Trav. Secur. Soc.! VOL 38, ISS 4-5, 1977,415-25 FRE SL 030365 00013978 1,1,1-TRICHLOROETHANE PAGE 19 U0 ii l CODEN ABSTRACT CAS REGISTRY NUMBER DATA TAG DATA TAG ENTRY MONTH 3 SECONDARY SOURCE ID AUTHOR TITLE SOURCE PUBLICATION TYPE LANGUAGE CODEN ABSTRACT KEYWORDS CAS REGISTRY NUMBER ENTRY MONTH 29 SECONDARY SOURCE ID AUTHOR ADDRESS TITLE SOURCE LANGUAGE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 25 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE AMPMA CBAC COPYRIGHT: CHEM ABS In human males exposed to 1,1,1-trichloroethane II) (213 or 72 ppm) for 8 h the absorption rate changed continuously with a retention rate between 26-32/!. (71-55-6 1,1,1-Tr i chloroethane) Pulmonary elimination over a period of 8 days was .apprx.90X. Urinary excretion of the metabolites (e.g., trichloroacetic acid and trichloroethanol) was slow and lasted .apprx.12 days. (76-03-9 Trichloroacetic acid)(115-20-8 Trichloroethanol) The urinary metabolites may be used as a biol. indicator of exposure to I. 71-55-6; 76-03-9! 115-20-8 URINE CONCENTRATION BLOOD CONCENTRATIONS 7712 ETIC/78/006577 IKEDA M TOXICITY OF 1,1,1-TRICHLOROETHANE SANGYO IGAKUiJPN J IND HEALTH); 20:359-366,1978 Journal Article ENG SAIGB ETIC/0RNL 1,1,1-TRICH LOROETHANE 71-55-6 8906 CA/091/000821X Ikeda M Sch. Med., Tohoku Univ., Sendai Toxicity of 1,1,1-trlchloroethane Sangyo Igakui VOL 20, ISS 6, 1978,359-66 JPN SAIGB CBAC COPYRIGHT: CHEM ABS A review with 52 refs, on 1,1,1-trichloroethane toxicity. (71-55-6 1,1,1-Trichloroethane) 71-55-6 7907 HEEP/79/08663 KRAMER CG OTT MG FULKERSON JE HICKS N IMBUS HR Dow Chem. Co., Midland, Mich., USA. Health of workers exposed to m m\ a &I a a 00013979 1,1,l-TRICHLOROETHANE PAGE 15 o o u 030366 SI* o SOURCE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 26 SECONDARY SOURCE ID AUTHOR ADDRESS TITLE SOURCE LANGUAGE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 1,1,1-triehloroethane: A matched-pair study. ARCH ENVIRON HEALTH*, 33 (6). 1978 (RECD. 19795. 331-392. AEHLA HEEP COPYRIGHT: BIOL ABS. An epidemiologic study of 151 matched pairs of employees was conducted in 2 adjacent textile plants, one of which used inhibited 1,1,1-trichlcreothane as a general cleaning solvent. Employees in the study population had exposures to the solvent for 6 yr or less at varying concentrations which were measured by breathing zone sampling and personal monitoring. While cardiovascular and hepatic observations were of primary interest, other health parameters were studied. Application of sensitive statistical techniques and careful examination of all data did not reveal any clinically pertinent findings that were associated with exposure to 1,1i1-trichloroethane. The statistically significant associations that were observed between health measures and nonexposure factors emphasize the need to consider age, sex, race and other variables in designing epidemiologic studies. 71-55-6 7908 CA/099/199977Z Lapp T Midwest Res. Inst., Kansas City An assessment of trichloroethylene, methylchloroform, and perchloroethylene U. S. Environ. Prot. Agency> Off. Res. Dev., [Rep.5 EPA! ISS EPA-600/9-80-003, Proc. Conf. Methyl Chloroform Other Halocarbon Pollut.,, 1980,12/1-12/13 ENG XPARD CBAC COPYRIGHT: CHEN ABS The manuf., use, and environmental and health effects ofC12C:CHCl, HeCC13, and C2C19 are reviewed. (79-01-6 Trichloroethylene)171-55-6 Methylchloroform){127-18-9 Perchloroethylene5 79-01-6S 71-55-6J 127-18-9 J 00013980 1,1,1-TRICHLOROETHANE PAGE 16 m & 27 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE CODEN ABSTRACT 030367 SL CAS REGISTRY NUMBER ENTRY MONTH SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE HEEP/78/10239 LARSBY B THAM R ODKVIST LM NORLANDER B HYDEN D ASCHAN G RUBIN A Dep. Otolaryngol.i Linkoping Univ., Reg, Univ. Hosp.> S-58185 Linkoping, Sued. Exposure of rabbits to methylchloroform: Vestibular disturbances correlated to blood and cerebrospinal fluid levels. INT ARCH OCCUP ENVIRON HEALTH; 91 til. 1978 7-16 IAOHD HEEP COPYRIGHT: BIOL ABS. A previously described experimental model for studying the effects on the CNS of rabbits> specifically the vestibular apparatus> Mas applied to methylchloroform. To achieve a steady concentration the- solvent was infused as a lipid emulsion. The blood and CSF kinetics were studied. The arterial blood level seems to be closely correlated to the concentration in the CHS tissue. Vestibular function was studied by recording the involuntary eye movementsi nystagmus, which are elicited via central vestibulo-oculomotor connections. At blood levels of methylchloroform above 75 ppm a so-called positional nystagnus, indicating vestibular disturbances, is demonstrated. The relationship between the present findings in rabbits and the reaction and blood concentrations in people exposed to industrial solvents, are discussed. 71-55-6 7309 HEEP/77/11664 MARONI M BULGHERONI C GRAZIA CASSITT0 M MERLUZZI F GILIOLI R FOA V Clin. Lavoro L. Devoto, Via S. Barnaba 6> Milano, Italy. A clinical, neurophysiological and behavioral study of female workers exposed to 1,1,1-trichloroethane. SCANO J WORK ENVIRON HEALTH*, 3 tli. 1977 16-22 o Q Q Q y y u 00013981 1,1,1-TRICHLOROETHANE PAGE 17 CODEN ABSTRACT 'J ii CAS REGISTRY NUMBER ENTRY MONTH 29 SECONDARY SOURCE ID AUTHOR ADDRESS TITLE W SOURCE W CODEN ABSTRACT w SL 030368 tj SMEHD HEEP COPYRIGHT: BIOL ABS. Female subjects (22) working in a factory in which 1,1,1-trichloroethane was the only solvent used were investigated by means of clinical, neurophysiological and psychometric methods so that the neurotoxicity of the solvent could be evaluated. On the basis of ambient air concentrations of 1>1>l-trichloroethane ranging from 110-990 ppm, the workers were divided into 3 risk groups and compared with a reference group. No significant difference was observed between exposed and unexposed females with respect to clinical features, maximal motor conduction velocity, conduction velocity of slow fibers, and psychometric data. The most frequent complaints of the workers were of the neurotic type with a slightly higher, but not significant, difference in the exposed group. Results obtained favor, the absence of a manifest neurotoxic effect of 1,1,1-trichloroethane under the specific work conditions of the investigation; generally unfavorable work conditions seem to have played a prominent role in the genesis of the neurotic complaints. The importance of a global methodological approach in the study of work-related risks, particularly in the neurological and psychological surveys, is stressed. 71-55-6 7712 HEEP/79/13073 MONSTER AC Coronel Lab., Fac. Med., Inst. Occup. Environ. Health, Univ. Amst., Eerste Constantijn Huygansstr. 20, Amsterdam, Neth. Difference in uptake, elimination, and metabolism in exposure to trichloroethylene, 1,1,1-trichloroethane and tetrachloroethylene. INT ARCH OCCUP ENVIRON HEALTH; 42 (3-4). 1979. 311-318. IAOHD HEEP COPYRIGHT: BIOL ABS. The relatively high and almost constant absorption/min of trichloroethylene (TRI) is explained by the relatively high partition coefficient between blood and air (lambdab/g = 15) combined with the rapid metabolism (75k). Tetrachloroethylene (PERC) has about the some iambdab/g as TRI but the metabolism is 00013982 1,1,1-TR1CH LOROETHANE PAGE 18 CAS REGISTRY NUMBER ENTRY MONTH SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE CODEN ABSTRACT SL 030369 insignificant (2/)> thereforei the amount taken up per min decreases in the course of exposure. The lambdab/g (5) for l>l>l-trichloroethane (MC) is smaller and the metabolism is insignificant (3.5/ ); therefore) the capacity of the body to absorb MC is relatively small and the uptake per min decreases fast during exposure. Due to the lower lambdab/g the excretion of MC after exposure is much faster than that of PERC. As a result of the metabolism of TRI only a relatively small amount of TRI absorbed is excreted by the lungs after exposure. (This study is relevant to occupational toxicology.) 127-18-4; 79-01-6) 71-55-6 7911 HEEP/79/12716 MONSTER AC BOERSMA G STEENWEG H Corone1 Lab.> Inst. Occup. Environ. Health) Fac. Med.* Univ. Amst.t Eerste Constantijn Huygensstr. 20) Amsterdam) Neth. Kinetics of 1>1>1-trichloroethane in volunteers: Influence of exposure concentration and work load. INT ARCH OCCUP ENVIRON HEALTH; 42 (3-4). 1979. 293-302. IAOHD HEEP COPYRIGHT: BIOL ABS.- Six male volunteers were exposed for 4 h to 70 ppm 1) 1 )l-trichloroethane (methylchloroform( MC) at rest) to 145 ppm MC at rest and to 142 ppm MC at rest combined with work load (2 times 30 min> 100 work). Minute volume and concentration in exhialed air were measured to estimate the uptake. MC and its metabolites trichloroethanol (TCE) and trichloroacetic acid (TCA) were determined in blood) exhaled air and urine. The uptake/m in decreased in the course of exposure to 30/ of the initial uptake. The total uptake was more influenced by minute volume than by body weight or amount of adipose tissue. During work load the uptake increased to 2.3-fold and the minute volume to 3-fold the value at rest. In the post exposure period the quotients of the concentrations in blood and in exhaled air for MC and TCE remained nearly constant at 8.2 and 14)000) respectively. Following exposure about 60-80/ of the amount taken up was excreted unchanged by the lungs) 00013953 11,1-TRICHLOROETHANE PAGE 19 a o w a w w SL 030370 0 CAS REGISTRY NUMBER ENTRY MONTH 31 SECONDARY SOURCE ID AUTHOR AUTHOR ADDRESS TITLE SOURCE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 32 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE while until 70 h after exposure the amount of TCE and TCA excreted in urine represented about 2V. and 0.5/1 of the uptake. (This study is relevant to occupational toxicology.) 71-55-6 7911 HEEP/'79/13074 MONSTER AC HOUTKOOPER JM Coronel Lab.> Fac. Med.j Inst. Occup. Environ. Healtht Univ. Amst.i Eerste Constant!jn Huygensstr. 20> Amsterdam^ Neth. Estimation of individual uptake of triehloroethylene > 1>1,1-trichloroethane and tetrachloroethylene from biological parameters. INT ARCH OCCUP ENVIRON HEALTH! 92 (3-9). 1979. 319-329. IA0HD HEEP COPYRIGHT: BIOL ABS. The results of single exposure studies with exposure to trichloroethylene (TRI)( to ltl.l-trichloroethane (MC) and to tetrachloroethylene (PERC) were used to study the precision in estimating the individual uptake from measured biological parameters after exposure. With simple linear and multiple linear regression analysis the individual uptake of TRIt MC and PERC was estimated from the concentrations of solvents and metabolites in biological media (blood> urine and exhaled air) at 2 h and at 20 h after exposure. The best results are obtained by estimation from the concentrations in blood> particularly of the solvents themselves. Including results of simultaneously measured concentrations in exhaled air or urine did not improve the estimate. (This study is relevant to occupational toxicology. ) 127-18-9! 79-01-6! 71-55-6 7911 CA/092/027893P Ohta T Nakamura H 11 ami J Itani T Ogawa T Aoyama H Med. Sch. Okayama Univ.* Okayama Intoxication of methylchloroforra workers 'J W *4 krf h* V t# <8# % o 00013964 1,1,1-TRICHLOROETHANE PAGE 20 SL 030371 SOURCE LANGUAGE C00EN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 33 SECONOARY SOURCE ID AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH Rodo Kagaku', VOL 55, ISS 4, 1979,215-20 JPN ROKAA cru: COPYRIGHT! CHEM ABS Three eases are reported of acute intoxication due to a solvent contg, mainly methylchloroform. (71-55-6 Methylchloroform) 71-55-6 6002 HEEP/78/05099 SAVOLAINEN H PFAFFLI P TENGEN M VAINIO H Dep. Ind. Hyg. Toxicol., Inst. Occup. Health, Haartmaninkatu 1, SF-00290 Helsinki 29, Finl. Trichloroethylene and 1,1,1-trichloroethane: Effects on brain and liver after five days intermittent inhalation. ARCH TOXICOL; 38 (3). 1977 229-237 ATXKA HEEP COPYRIGHT: BIOL ABS. The inhalation exposure of adult male rats to 7.9 mumol/1 (200 ppm) of trichloroethylene for 4 days, 6 h each day led to an accumulation of the solvent in the perirenal fat 17 h after the last exposure. Exposures to 20 mumol/1 (500 ppm) of 1,1,1-trichloroethane caused similar accumulation. The latter rats presented no changes in their behavior in an open-field test, whereas the motor behavior of the animals exposed to trichloroethylene was more active in comparison to controls 1 h after the exposure on the 4th day. Trace effects of trichloroethylene on emotional behavior of the same rats could be seen 17 h after the last exposure. Further exposures on the 5th day increased brain, liver, lung and blood contents of trichloroethylene and 1.1.1-trichloroethane. A slight decrease in brain RNA content was found in the 1.1.1-trichloroethane exposed rats while RNA decreased significantly after the 5th day of trichloroethylene inhalation. The exposure to 1,1,1-trichloroethane on the 5th day depressed also the microsomal cytochrome P-450 content in liver of rats, whereas trichloroethylene increased the hemochrome content slightly at the same time. 79-01-6; 71-55-6 7607 00013985 1,1,1-TRICHLOROETHANE PAGE 21 34 SECONDARY SOURCE ID CA/085/117505Q & AUTHOR Shah HC AUTHOR Lai H <wl ADDRESS Coll. Pharm., Univ. Rhode Island, Kingston, R. I. TITLE Effects of 1,1,1-trichloroethane administered by different routes and in different solvents SOURCE on b-i. hiturate hypnosis and metabolism in mice J. Toxicol. Environ. Health; VOL 1> ISS 5, V# 1976,807-16 LANGUAGE ENG CODEN JTEHD ABSTRACT CBAC COPYRIGHT: CHEM ABS Exposure of male mice to 1,1,1-trichloroethane tl) (3000 ppm) for 24 hr decreased the duration of Na pentobarbital hypnosis and the hexobarbital oxidase activity in 9000 .times, g liver supernatant fractions. (71-55-6 1,1,1-Trichloroethane)(57-33-0 Sodiurn & pentobarbital)(9059-12-5 Hexobarbital oxidase) By contrast, I administered by the i.p. route increased the pentobarbital hypnosis and decreased hexobarbital metab. by the liver microsomal enzymes . (50-09-9 Hexobarbital) The potentiating effect of I on pentobarbital hypnosis was diminished when I was dild. with olive oil, but was enhanced when dild. with DM50 before injection. Local application of I (1:1 diln. with DMSO) had an effect similar to that of inhalation on pentobarbital hypnosis. CAS REGISTRY NUMBER ENTRY MONTH 71-55-61 57-33-Of 9059-12-5! 50-09-9! 67-68-5 7612 V* 35 SECONDARY SOURCE ID CA/093/119542P AUTHOR W AUTHOR Simonov VA Strugova NA AUTHOR Grabovskii OZ TITLE Colorimetric determination of w SOURCE methylchloroform vapors in air Kompleks. Probl. Okhrany Truda, M.; 1979,113-16 LANGUAGE RUS CODEN D4JOU ABSTRACT CBAC COPYRIGHT: CHEM ABS Title only translated. Methylchloroform detn air colorimetry Trichloroethane detn air colorimetry CAS REGISTRY NUMBER 71-55-6 ENTRY MONTH 8010 V* 00013998Sio 1,1,1-TRICHLOROETHANE PAGE 22 C* ) 36 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR TITLE SOURCE LANGUAGE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 37 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE LANGUAGE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH CA/O93/119471Q Simonov VA Strugova NA Grabovskii OZ Linear-coloristic method for the determination of methylchloroform vapors in the air Kompleks. Probl. Okhrany Truda, M.; 1979,113-16 RUS D3RAP CBAC COPYRIGHT: CHEM ABS Title only translated. Chloroethane detn air colorimetry Colorimetry trichloroethane detn ai r 71-55-6 8010 CA/091/162370B Vanlaethem-Meuree N Wisemberg J Simon PC Inst. Aeron. Spat. Belgique, Brussels Ultraviolet absorption spectrum of methylchloroform in the vapor phase Geophys. Res. Lett.; VOL 6, ISS 6, 1979,451-4 ENG GPRLA CBAC COPYRIGHT: CHEM ABS UV absorption cross sections of methylchloroform (I) were measured in the wavelength interval 180-240 nm and temp, range 210-295 K. 171-55-6 Methylchloroform) Numerical values are given and compared with existing data at ambient temp. Photodissocn. coeffs. were calcd. for altitudes between 20 and 45 km and appear to be significantly lower than generally considered. The substantial decrease in absorption cross sections obsd. at low temps. and lambda >210 nm has only a minor influence on overall photodissocn. coeffs. Relative contributions of photodissocn. and reaction with OH radicals as potential sinks for I at stratospheric altitudes are briefly discussed. 71-55-6; 10028-15-6 7912 ) 'J J :j \) j j 03^ 3 03 11 > * # 1 P0091931 *#*#***##*********#*********#******###************#**#*##)< *K * THIS IS AH OFF-LINE BIBLIOGRAPHIC CITATION LIST GENERATED BY * ** * MEDLARS II * ** * N.L.M.'S NATIONAL INTERACTIVE RETRIEVAL SERVICE * * # ** **##### xyjm *## #######*#### K * * X a###*########## ###K * # * ftKftit * * # ##### ####### 1,1,1-TRICHLOROETHANE NUMBER OF CITATIONS PRINTED = 89 THIS SEARCH WAS PERFORMED ON THE TOXLINE MAY 20, 1986 FILE. SORT = (ELEMENTS/DIRECTIONS GIVEN BY USER) WAS SPECIFIED Aii lijvi/ui oJSi. Toxii^i Fde-y Toxtfi\OC.70j JovOr^d l&XL/rJB (fb nz<*)%Q>oii iXaX. j} I) f~ / t/iJdijyQcMA-rUt-' PLEASE SEND THIS LISTING TO i'xJ-tL' -`fct**- n.4astJLs Tt'Lt-. DIANA DANKO / PPG INDUSTRIES,INC. P.0. BOX 31 BARBERTON, OHIO 99203 03037* SL 00013751 1,1, 1-TRICKLOROETHANE PAGE 1 J O & # sz. 030375 1 SECONDARY SOURCE ID ADDRESS TITLE SOURCE LANGUAGE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH SECONDARY SOURCE ID CLASSIFICATION CODE CORPORATE NAME ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE LANGUAGE CA/O95/019225K Mas hi rig ton Dichloromethane, nitrobenzene and 1>1tl-trichloroethane; proposed test rule Fed. Regist.; VOL <46, ISS 108, 1981,30300-20 ENG FEREA CBAC COPYRIGHT: CHEM ABS It is proposed that CK2C12, ni trobenzene, and 1.1.1-trichloroethane be tested for human and environmental effects by manufacturers and processors. (75-09-2 Dichioromethane)(98-95-3 Nitrobenzene)(71-55-6 1,1,1-Trichloroethane ) The tests proposed for CH2C12 are: acute dermal sensitization, subchronic cardiovascular toxicity, reproductive toxicity, chronic toxicity to aquatic vertebrates, acute and chronic toxicity to aquatic invertebrates and birds, effects on early seedling growth, and plant uptake or translocation and aquatic vertebrate concn. Tests for nitrobenzene include: reproductive toxicity and structural teratogenicity, mutagenicity, acute and chronic toxicity to aquatic vertebrates and birds, chronic toxicity to aquatic invertebrates, root elongation/seed germination, early seedling growth, plant uptake/translocation, and soil adsorption effects. Tests proposed for 1.1.1-trichloroethylene include: structural teratogenicity, acute and chronic toxicity to aquatic vertebrates, chronic toxicity to aquatic invertebrates and birds, early seedling growth, root elongation/seed germination, and uptake/translocation. Procedures to be used are specified. 75-09-2; 98-95-3; 71-55-6 8108 CA/102/031268R CA/159005 United States Environmental Protection Agency Hashington Identification of specific chemical substance and mixture testing requirements; 1.1.1-trichloroethane Fed. Regist.; VOL 69, ISS 197, 1986,39810-18 JOURNAL ARTICLE USA 20660 ENG *T 000^^2 1,1,1-TRICHLOROETHANE CODEN INTL STAND SER NO ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 3 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR TITLE SOURCE PUBLICATION TYPE LANGUAGE ABSTRACT KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS CAS REGISTRY NUMBER ENTRY MONTH 4 SECONDARY SOURCE ID AUTHOR TITLE SOURCE' PUBLICATION TYPE LANGUAGE CODEN ABSTRACT KEYWORDS KEYWORDS KEYWORDS CAS REGISTRY NUMBER ENTRY MONTH FEREA 0097-6326 CBAC COPYRIGHT: CHEM ABS Methyl chloroform toxicity testing Chloroethane teratogenesis testing;Standards For trichloroethane teratogenicity testing Legal and permissiveSTeratogens Trichloroethane testing in relation toi stds, for 71-55-6 6502 CIS/85/00713 120 ANON 1,1iI-Trichloroethane Safety Practitioner Apr. 1984, Vol.2, No.4, p.17-18. 11 ref. JOURNAL ARTICLE Eng Contents of this data sheet: properties and uses; hazardous chemical reactions and fire behaviour; toxicity; safety precautions; first aid and emergency procedures. 1,1,1-TRICH LOROETHANE UNITED KINGDOM ORGANIC SOLVENTS DATA SHEET FIRST AID TOXIC EFFECTS ILO 71-55-6 8508 ETIC/81/002318 ANONYMOUS OICHLOROMETHANE, NITROBENZENE AND 1.1.1-TRICHLOROETHANE; PROPOSED TEST RULE FED REGISTJ 46=30300-30320,1981 Other ENG FEREA ETIC/ORNL DICHLOROMETHANE NITROBENZENE 111.1-TRICHLOROETHANE 75-09-2; 98-95-3; 71-55-6 8408 000^^53 1,1,1-TRICHLOROETHANE PAGE 3 5 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY LANGUAGE CODEN INTL STAND SER NO ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 6 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE LANGUAGE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH CA/097/097586J CA/159005 Badinailt L Fabricere Inc., Stamford Inhibited trich1oroethane Chem. Eng. Nansi VOL 60, ISS 28, 1982,A JOURNAL ARTICLE USA ENG CENEA 0009-2347 CBAC COPYRIGHT'- CHEM ABS Trichloroethane lowering solvent flash point Petroleum solvent flash point lowering;Flash point Of petroleum solvents, lowering of, by trichlcroethane[Solvents Petroleum, flash point lowering by trichloroethane addn. 71-55-6 8210 CA/097/097968K CA/161002 Bailey RE Crain RM Goergen MG Ecol. Consult., Mt. Pleasant Cleanup and monitoring procedures for a methylene chloride and 1,1,1-trlchloroethane spill at Sault Ste. Marie, Michigan Hazard. Mater. Spills Conf. Proc.j 1982,28-36 MONOGRAPH USA 48858 ENG 48AMA CBAC COPYRIGHT: CHEM ABS Hazard chem spill filtration monitoring Methylene chloride water pollution swamp Trichloroethane water pollution swamp;Water pollution By methylene chloride and trichloroethane, from tank truck spill, cleanup and monitoring of, in Michigan, USA I Water purification By activated carbon, methylene chloride and trichloroethane removal by, from swamp water contaminated by tank truck spill, in Mi chigan , USA Adsorption 71-55-6! 75-09-2 8210 00013754 1,1,1-TRICHLOROETHANE PAGE 4 7 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR AUiMOR AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE LANGUAGE CODEN INTL STAND SER NO ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH CA/I04/063n/G CA/I04003 Blohm M Braun H Kaschny P SchUl H Jastorff B Diehl H Fachber. 1 Phys./Elektrotech., Univ, Bremen, Bremen Subacute toxicity of 1,1,1-trichloroethane, noise, and their combination in rats Ecotoxicol. Environ. Saf.5 VOL 10, ISS 3, 1985,245-301 JOURNAL ARTICLE Fed. Rep. Ger. D-2800/33 ENG EESAD 0147-6513 CBAC COPYRIGHT: CHEM ABS Parallel groups of rats were simultaneously exposed To defined conditions til 1,1,1-trichloroethane (TCE) 171-55-63 vapor; (iij noise pollution of 90 decibels; (iii) their combination; and tiv) a control group without any exposure. The vapor of TCE was applied at a concn. of 200 ppm/8 h or of 2000 ppm/12 h for 84 days each. The expts. were performed with TCE from 2 different com. sources. One of those TCE prepns. caused effects at the high dosage level in terms of enhanced levels of (i} the relative of liver to body wt.; Mi) liver microsomal protein content; tiii) liver microsomal monooxygenase [9038-14-6] activity; and (iv) 3,4-dihydroxyphenylglycol C3343-19-9] excretion in urine. Eight other physiol, and biochem, parameters were not changed. The other TCE prepn. at the high dose, both TCE prepns. at the low dose, and noise did not affect the investigated parameters. 71-55-6; 79-00-5! 3343-19-9; 9038-14-6 8604 00013755 1>1i1-TRICHL0R0ETHANE PAGE 5 SECONDARY SOURCE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS ID TITLE SOURCE Q CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 9 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR TITLE SOURCE PUBLICATION TYPE LANGUAGE ABSTRACT SL 030379 i HEEP/83/00569 CAPEROS JR DROZ PO HAKE CL HUMBERT BE JACOT-GUILARMOD A Chem. Inst. Univ. Neucbatel> Bellevaux 51, CH-2000 Neuchat el, Suits. 111>1-trichlorosthane exposure, biologic monitoring by breath and urine analyses. INT ARCH OCCUP ENVIRON HEALTH; 99 (3-9). 1982. 293-309. IAOHD HEEP COPYRIGHT: BIOL ABS. Absorption and excretion of 1,1>1-trichloroethane , and the kinetics of formation and elimination of trichloroethanol (TCE) and trichloroacetic acid (TCA) uere simulated by a mathematical model. The results uere compared uith experimental ones on pulmonary elimination of the solvent and urinary exertion of the metabolites. The .influences of duration and repetition of exposure on the pulmonary and urinary eliminations uere studied. A tentative method of biologic monitoring was proposed. Theoretically, the most suitable method to estimate the exposure uas by 2 determinations) before and after a work shift. Following this procedure) analysis of TCE in the urine was more sensitive than determination of 1)1>1-trichloroethane in the breath. As an indicator of exposure risk) TCA was not sensitive enough if variations in the inspired concentration occurred. 115-20-8; 76-03-9; 71-55-6 8301 CIS/83/00967 130 Caperos JR Droz PO Hake CL Humbert BE Jacot-Guillarraod A 1)1)1-Trichlorcethane exposure > biologic monitoring by breath and urine analyses International Archives of Occupational and Environmental Health Feb. 1982> Vol.99, No.3-9, p.293-303. Ulus. 16 ref. JOURNAL ARTICLE Eng Absorption and excretion of 1,1.l-TRICHLOROETHANE PAGE 6 KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS CAS REGISTRY NUMBER ENTRY MONTH 10 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY LANGUAGE COOEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 1.1.1- trich1oroethane, the kinetics of formation and elimination of trichloroethanol (TCE) and trichloroacetic acid (TCA) are simulated by a mathematical model. The results of this model are compared with experimental data on pulmonary elimination of the solvent and urinary excretion of the metabolites. The influence of duration and repetition of exposure on the pulmonary and urinary el imitation are studied. A tentative method of biological monitoring is proposed: determinations before and after the work shift; analysis of TCE in the urine. As an indicator of exposure risk, TCA is not considered sensitive enough if variations in the inspired concentration occur. TRICHLOROETHANE EXPOSURE TESTS URINE MONITORING MATHEMATICAL MODELS COMPARATIVE STUDY ILO 71-55-6 8411 CA/098/192727K CA/104000 Carchman R Davidson IW F Greenberg MM Parker JC Environ. Critenia Assess. Off., Environmental Protection Agency, Research Triangle Park Health assessment document for 1.1.1- trichloroethane Imethylehloroform) (revised draft ) Report; ISS EPA-600/8-S2-003; Order No. PB83-129585,, 1982,180 pp. TECHNICAL REPORT USA ENG DSREP CBAC COPYRIGHT: CHEM ABS A review and discussion on the health assessment of methylchloroform 171-55-6] . 71-55-6 8307 030380 SL 3I 000 7 1,1,1-TRICHLOROETHANE PAGS^ 7 i Ci U SECONDARY SOURCE ID CA/101/176755T (J CLASSIFICATION CODE CA/159006 AUTHOR Carchman R AUTHOR AUTHOR Davidson IW F Greenberg MM M> AUTHOR Parker JC AUTHOR Beni gnus V ADDRESS Environ. Criteria Assess. Off., Environ. Prot. Agencyi Research Triangle Park # TITLE Health assessment document for 11111-trich1oroethane (methyl chloroform) Q SOURCE Report; ISS EPA-600/8-82-003F; Order No. PB84-183565,, 1984,181 pp. PUBLICATION TYPE TECHNICAL REPORT COUNTRY USA LANGUAGE ENG CODEN D8REP ABSTRACT CBAC COPYRIGHT: CHEM ABS Methyl chloroform exposure health hazareUAir pollution By Me m chloroform, exposure to, health hazard ofJWater pollution By Me chloroform, health hazard of CAS REGISTRY NUMBER 71-55-6 ENTRY MONTH 8412 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY LANGUAGE CODEN INTL STAND SER NO ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH CA/098/149306K CA/161002 Copelli M Gardini GP 1st. Ecol., Univ. Parma, Parma Migration of 1,1,1-trichln oethane in soil Boll. Chim. Unione Ital. Lab. Prov., Parte Sci.; VOL 33, ISS 54/55, 1983,339-44 JOURNAL ARTICLE Italy ITA BCUSD 0390-8585 CBAC COPYRIGHT: CHEM ABS Soil pollution trich1oroethane migration;Accidents Trichloroethane spills, migration of, in soils!Soil pollution By trichloroethane spillstWater pollution By trichloroethane spills, of groundwater 71-55-6 6305 SL 030381 II ooor I>ltl-TRICHLOROETHANE 13 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE LANGUAGE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR TITLE SOURCE PUBLICATION TYPE COUNTRY LANGUAGE CODEN INTL STAND SER NO ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH CA/096/099036H CA/104003 Elias Z Hartemann P Chau N Inst. Natl. Rech, Secur.> Vandoeuvre-les-Nancy A study of the cytotoxicity of chloroform, 112-dichloroethan-j, 1 > 1, 1-tri chloroethane and hexachlorobutadi -ne to mouse L cells Toxicol. Eur. Res.; VOL 3, ISS 6, 1981,293-8 JOURNAL ARTICLE Fr. 54500 FRE TOERD CBAC COPYRIGHT: CHEtl ABS A cytotoxic* ty test based on residual protein detn. is described and the in vitro toxicity of certain chlorinated aliph. hydrocarbons is evaluated. The results obtained are sufficiently reproducible to yield an order of cytotoxicity: hexachlorobutadiene [87-68-31 is .apprx.10-fold more toxic than chloroform [67-66-31 or 1,2-dichloroethane [107-06-21, whereas 1,1,1-trichloroethane [71-55-61 is 10-fold more toxic than these 2 covnpds. The method is fast and may be useful in toxic evaluation of large nos. of samples. 67-66-3! 71-55-6; 87-68-3;'107-06-2 6205 CA/102/144150M CA/104000 Fielder RJ Mill i elms SD 1, 1, 1-Trichloroethane Toxic. Rev.i VOL 9,, 1984,46 pp. JOURNAL ARTICLE UK ENG T0RVD 0264-5920 CBAC COPYRIGHT: CHEM ABS A review with 160 refs, on the toxicity and metab. of 1,1,1-trichloroethane [71-55-61 in humans and lab. animals. 71-55-6 6505 030382 SL 000 9 1,1,1-TRICHLOROETHANE PAG! 9 15 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR TITLE SOURCE PUBLICATION TYPE LANGUAGE ABSTRACT KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS CAS REGISTRY NUMBER CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH 16 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE SL 030383 CIS/85/01033 120 Fielder RJ Wi!1 iams SD 111.1- Trichloroethane HM Stationery Office, 49 High Holborni London WC1V 6HB, United Kingdom, 1984. 46p. 164 ref. MONOGRAPH Eng Contents * metabolic studies in animals and man; toxicity to animals (acute toxicity, skin and eye irritancy, subacute/subchronic toxicity, mutagenicity, carcinogenicity, effects on the reproductive system); toxicity to man (acute toxicity, skin and eye irritancy, effects of repeated exposure). In man, trichloroethane has high absorbancy, but most (over 70/.) of the absorbed material is excreted unchanged through the breath. Only a small amount is metabolised (metabolites identified are ,2,2-trichloroethanol and trichloroacetic acid). These metabolites are excreted in the urine. The toxicity of the substance is low: occupational exposure of up to 350ppm produces no effect, and at SOOppm there is a very small effect noted in behaviour tests. Definite central nervous system symptoms start at 900ppm. 1.1.1- TRICHL0R0ETHANE TOXICOLOGY METABOLIC PROCESS TOXIC EFFECTS CENTRAL NERVOUS SYSTEM 110 71-55-6 115-20-8 76-03-9 8508 CA/104/039336E CA/161002 Fogelqvist E Dep. Anal. Mar. Chem., Chalmers Univ. Technol., Goeteborg Carbon Tetrachloride, tetrachloroethylene, I, 1,1-trichloroethane and bromoform in Arctic seawater J. Geophys. Res., C`- Oceans; VOL 90, ISS C5, 1985,9181-93 JOURNAL ARTICLE Sued. S-41296 0001 1.1.1-TRICKLOROETHAME PAGE^lO LANGUAGE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 17 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE LANGUAGE CODEN INTL STAND SER NO ABSTRACT St 030384 ENG JGRCE CBAC COPYRIGHT: CHEtl ABS Seawater halocarbon Arctic.Hydrocarbons In seawater, of Arctic Ocean, air-sea exchange of halocarbons in relation to HalojWater pollution By halocarbons. of Arctic Ocean, air-: exchange in relation to 56-23-5; 71-55-6; 75-25-2; 127-18-A 8603 CA/101/185A33P CA/109003 Folberqrova J Hougaard K Westerberg E Siesjoe BK Lund Hosp.. Univ. Lund. Lund Cerebral metabolic and circulatory effects of 1.1.1-trichloroethane, a neurotoxic industrial solvent. 2. Tissue concentrations of labile phosphates, glycolytic metabolites, citric acid cycle intermediates, amino acids, and cyclic nucleotides Neurochem. Pathol.! VOL 2,' ISS 1, 198A,55-68 JOURNAL ARTICLE Sued. S-221 85 ENG NEPAD 0734-600X CBAC COPYRIGHT: CHEN ABS To study the mechanisms of neurotoxicity of 1.1.1-trichloroethane (I) [71-55-61, rats maintained artificially ventilated on N20:0 (70:30) were exposed to a concn. of I of 8000 ppm that induced moderate ataxia in awake, spontaneously breathing animals. After 5 and 60 min of exposure, as well as after a 60-min recovery period following 60 min of exposure, the brain was frozen in situ and *. e> tical tissue was assayed for phosphocreatine 167-07-21 , ATP [56-65-51 , ADP [58-60-01 , AMP (61-19-81 , glycogen [9005-79-21 , glucose [50-99-71 , pyruvate [127-17-31 , lactate [50-21-51. citric acid cycle intermediates, assocd. amino acids, and cyclic nucleotides; in addn., purtne nucleotides, nucleosides, and bases were assayed by HPLC techniques. Exposure of animals to I failed to alter blood glucose, lactate, and pyruvate concns. However, the 1 00013761 1,1,1-TRICHLOROETHANE PAGE 11 solvent induced highly significant increases in tissue lactate and pyruvate concns. Assocd. with these changes were increases in tissue lactate and pyruvate concns. Assocd. with these changes were increases in all citric acid cycle intermediates except succinate [110-15-61, an increase in alanine [56-41-73 concn., and a rise in the glutamate C56-S6-01/aspartate [56-84-81 ratio. After 5 min, a small decrease in glycogen concn. also occurred. All these changes were reversed when the exposure was terminated. No changes were obsd. in tissue concns. of purine nucleotides, nucleosides, and bases except for a small redn. of ATP # concn. after 60 min of exposure, still noticeable after 60 min of recovery. Apart from a small redn. in cAMP [60-92-43 concn. after 5 min of exposure, cyclic nucleotide # concns. did not change. CAS REGISTRY NUMBER 50-21-51 50-99-7; 56-12-2! 56-41-7! 56-65-5; 56-84-8; 56-85-9; 56-86-0! 58-61-7; 58-64-0; 58-97-9! 58-98-0! 60-92-4; 61-19-8! 63-38-7; 63-39-8! 65-47-4; 67-07-2! 68-94-0; 69-89-6! 71-55-6! 85-32-5; 86-01-1; 110-15-6; 110-17-8; 127-17-3; 131-99-7; 146-91-8; 328-50-7; 6915-15-7! 7665-99-8; 9005-79-2; 59785-05-6 ENTRY MONTH 8412 SECONDARY SOURCE ID AUTHOR AUTHOR ADDRESS TITLE SOURCE CODEN ' ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH HEEP/83/10307 CARDINI GP COPELII M 1st. Chim. Organica, Univ. Parma, 43100 Parma, Italy. Migration of 1,1,1-trichloroethane in soil. CHEMOSPHERE! ll (9). 1982. 921-924. CMSHA HEEP COPYRIGHT: BIOL ABS. The depth profile of the concentrations of 1,1,1-trichloroethane in soil was examined to detect its diffusion behavior after heavy surface pollution. 71-55-6 8309 030385 SL ** 1,1,1-TRICHLOROETHANE PAGE 12 * 19 SECONDARY SOURCE 10 CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE LANGUAGE CODEN INTL STAND SER NO ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 20 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE CODEN ABSTRACT SL 030386 n CA/097/086607R CA/109003 Caller I Mendez V Hartmann RJ Gause E Rippstein WJ Jr Southwest Found. Res. Educ., San Antonio Effects of 1,1,1-trichloroethane on a match-to-sample discrimination task in the baboon J. Toxicol. Environ. Health; VOL 9, ISS 5-6, 1982,783-95 JOURNAL ARTICLE USA 78289 ENG JTEHO 0098-9108 CBAC COPYRIGHT: CHEM ABS ADDENDUM Juvenile baboons (Papio anubis) were subjected to acute 9-h exposures to 700, 1900, 1800, and 2100 ppm 1,1,1-trichloroethane [71-55-6] no more frequently than once a week. Three months later a subchronic exposure to 1200 ppm was conducted over a 7-day period in the same animals. The effects on accuracy of responding were minimal; however, 1,1,1-trichloroethane reduced the no. of trials attempted by the animals, reduced the no. of extra inconsequential responses during the delay intervals, and increased reaction times. Thus, the young baboon can be used as a primate human surrogate model for testing this type of central nervous system depressant. 71-55-6 8905 HEEP/83/09273 GOODSHIP G HANN J SCUDAMORE KA Ministry Agric., Fish. Food, Slough Lab., Agric. Sci . Serv., London Rd., Slough, Berks. SL3 7HJ. Disappearance of 1,1,1-trlchloroethane from fumigated cereal grains and other foodstuffs during storage and processing. PESTIC SCI; 13 (2). 1982. 139-198. PSSCB HEEP COPYRIGHT: BIOL ABS. The sorption of 00013763 1,1,1-TRICHLOROETHANE PAGE 13 CAS REGISTRY NUMBER ENTRY MONTH El SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR TITLE SOURCE PUBLICATION TYPE LANGUAGE ABSTRACT l)l>l-trichlorethane (insecticide) by a variety of cereals and other foodstuffs during fumigation and the rates of loss during subsequent airingi were determined by GLC of solvent extracts. The results were discussed in relation to the variables that affected the sorption of fumigants on commodities and the subsequent residue behavior during storage. The loss of residue was measured at each stage of the processing of fumigated wheat into bread. Residues in A50 g loaves were < 0.1 mg/kg. A comparison of the sorption and residue data for 1>1>1-trichloroethanei with those obtained previously for CCl4i showed that the amounts of residues of the E compounds could be expected to be similar after their use in cereal fumigation. The less favorable data available for the mammalian chronic toxicology of CC14 indicated that considerable advantage would be gained by its replacement as a grain fumigant by 1 > 1 > 1-tr i chloroethane. 71-55-6! 56-E3-5 8308 CIS/83/0015A 130 Guillemin M Gub'eran E Value of the simultaneous determination of P-COtEl in monitoring exposure to lil>l-trichloroethane by breath analysis British Journal of Industrial Medicine May 198S* Vol.39, No.E, p.161-168. Ulus. 19 ref. JOURNAL ARTICLE Eng The P-COCE] was measured as a correction factor in the monitoring of solvent exposure by breath analysis. Volunteers were exposed to EOOppm 1,1,1-trichloroethane for 6h > and alveolar samples were taken 15-19H later by voluntary hyperventilation) 10-s breath holding and the "standard" method for simultaneous P-C0(2] and solvent determination. The results of breath analyses for solvent exposure should be corrected for hyperventilation or hypoventilation and for dilution of alveolar air with dead-space air by a proportional adjustment of the solvent concentration at the mean normal alveolar P-CO(] or by disregarding samples with a P-C0IE3 outside the normal range. Monitoring 00013764 1,1.1-TRICHLOROETHANE PAGE 14 KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH 22 SECONDARY SOURCE ID AUTHOR AUTHOR ADDRESS TITLE SOURCE CODEN ABSTRACT 03038s exposure by breath analysis would have little meaning without such an adjustment or rejection criterion. TRICHLOROETHANE ORGANIC SOLVENTS DETERMINATION IN EXHALED AIR CARBON DIOXIDE EXPOSURE TESTS HUMAN EXPERIMENTS ACCURACY PULMONARY VENTILATION ILO 71-55-6 124-38-9 6411 HEEP/83/04971 GUILLEMIN M GUBERAN E Institut Universitaire de Medecine du Travail at d'Hygiene Industrielle> route de la Clochatte) CH-1052 Le-Mont-Sur-Lausanne. Value of the simultaneous determination of carbon dioxide partial pressure in monitoring exposure to 1>1tl-trichloroethane by breath analysis. BR J INO MED! 39 (2). 1962. 161-168. BJIMA HEEP COPYRIGHT: BIOL ABS. Eight volunteers were exposed for 8 h tories of 5 alveolar samples were collected for the simultneous determination of PC02 (C02 partial pressure) and 1>1,1-trichloroethane concentration. Sampling methods were: voluntary hyperventilation> 10-s breathholding and standard. A linear relationship between the alveolar concentrations of both gases were observed in all subjects. Expired air was also collected in 2 subjects and an analogous relationship was observed. TKe Bohr dead space was found to be of similar sire for C02 and for 1>111-trichloroethane. In the monitoring of solvent exposure by breath analysis> the results should be corrected for hyperventilation or hypoventilation and for dilution of aLveolar air with dead space air by a proportional adjustment of the solvent concentration at the mean normal alveolar PC02 or by disregarding the samples with a PC02 outside the normal range. The PC02 determination in 40 unselected workers showed that in > l/3> to monitor exposure by breath analysis would have been of little meaning 00013765 1,1, 1-TRICHLOROETHANE PAGE 15 CAS REGISTRY NUMBER ENTRY MONTH 23 SECONDARY SOURCE ID CLASSIFICATION CODE u AUTHOR ADDRESS TITLE w SOURCE PUBLICATION TYPE COUNTRY LANGUAGE CODEN INTL STAND SER NO <# ABSTRACT # # # # CAS REGISTRY NUMBER # ENTRY MONTH 030389 s^ sI without such an adjustment or rejection criteria. 124-38-9; 71-55-6 8304 CA/097/176408F CA/104003 Hi rot a S Med. Sch., Okayama Univ.t Okayama Changes in hematologic parameters of dog due to exposure to trichloroethylene and 1i1,1-trichloroethane Okayama Igakkai Zasshi; VOL 94, ISS 3/4, 1982,211-20 JOURNAL ARTICLE Jap an JPN OIZAA 0030-1558 CBAC COPYRIGHT: CHEM ABS Dogs were exposed to trichloroethylene (TCL) [79-01-61 or 1,1tl-trichloroethane (TCE) [71-55-61 to investigate their effects on hematolog. parameters. Plus, the effects of several hormones given prior to the solvent exposure were investigated, because there were unusual changes in white blood cell (WBC) counts of pregnant dogs after the solvent exposure. WBC had a temporary marked decrease immediately after exposure to TCL or TCE, but red blood cell counts, hematocrit values, and blood platelet counts did not change. Each WBC parameter decreased in no., esp. neutrophils. TCL caused a greater decrease in WBC than TCE. A dose-response relation was seen between the concns. of TCE from 200 to 700 ppm, and the decrease in WBC. No change in WBC was obsd. following the exposure of pregnant dogs to TCE. Premedication with estradiol [50-28-23, proqesterone [57-83-03, and hydrocortisone [50 - 23 - 73 had a preventive effect on the decrease in WBC caused by the exposure to TCE, but no such effect was seen with premedication of testosterone [58-22-03. 50-23-7*, 50-28-2; 57-83-0*, 58-22-0*, 71-55-6*, 79-01-6 8212 * * * 1i1,1-TRICHLOROETHANE PAGE 16 24 SECONDARY SOURCE 10 CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR TITLE SOURCE PUBLICATION TYPE LANGUAGE ABSTRACT KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS CAS REGISTRY NUMBER ENTRY MONTH SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR SL 03039 CIS/84/01342 130 Hobara T Kobayashi H Higashihara E Iwamoto S Kawamoto T Sakai T Tsubota N Experimental examinations and toxicokinetic analysis of the absorption and excretion of 1,1>1-trichloroethane by the lung Japanese Journal of Industrial Health 1482, Vol.24, No.6, p.599-607. Illus. 21 ref. JOURNAL ARTICLE Jap Groups of 5 dogs inhaled 1>1>1-trichloroethane (TCE) at levels of 700, 1500 or 2000ppm for lh. Cumulative uptake of TCE was 27.3, 44.7 and 71.2mg/kg respectively. Excretion ratios were 66-71/ at all exposure levels. There was a highly significant negative correlation between the arterial:venous blood concentration ratio and the inspired:expired air concentration ratio during exposure. After exposure, there was a highly significant positive correlation between the concentrations in the expired air and the venous or arterial blood. Mean total absorption was 14/ of the inhaled quantity. Multiple regression equations were calculated for the exposure and post-exposure periods. TRICHLOROETHANE TOXICOLOGY DETERMINATION IN EXHALED AIR ORGANIC SOLVENTS BODY RETENTION DETERMINATION IN BLOOD ANIMAL EXPERIMENTS COMPARATIVE STUDY ILO 71-55-6 8502 CA/098/I74274F CA/104003 Hobara T Kobayashi H Higashihara E Iuamo t o S Kawamoto T Sakai T 000137ft7 1,1,1-TRICHLOROETHANE PAGE 17 AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE LANGUAGE CODEN INTL STAND SER NO ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 26 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE LANGUAGE CODEN INTL STAND SER NO ABSTRACT Tsubota N Sch . Mad. , Yamaguchi Univ., Ube Experimental examinations and toxicokinetic analysis of the absorption and excretion of 1,1 *1-trichloroethane by the lung Sangyo Igaku! VOL 29, ISS 6, 1982,599-607 JOURNAL ARTICLE J ap an 755 JPN SAIGB 0097-1879 CBAC COPYRIGHT: CHEM ABS Dogs inhaling 1,1,1-trichloroethane Cl) [71-55-6] at 700, 1500, and 2000 ppm showed cumulative I uptakes after 1 h of 27.3, 99.7, and 71.2 mg/kg, resp. I excretion after 1 h was 66-71Z at all 3 doses. During the exposure, a highly significant neg. correlation was seen between the arterial/venous blood concrt. ratio and expired/inspired air concn. ratio. In the postexposure period, highly significant pos. correlations were seen between expired air concns. and venous or arterial blood concns. The mean ratio of the total absorption value to the total inspired value was 19Z at all 3 levels of exposure. 71-55-6 8306 CA/100/080851Z CA/109003 Hobara T Kcbayashi H Higashihara E Kawamoto T Iwamoto S Sakai T Sch. Med., Yamaguchi lfniv. Ube Changes in hematologic parameters with acute exposure to 1,1,1-trichloroethane Ind. Health', VOL 21, ISS 9, 1983,255-61 JOURNAL ARTICLE Japan 755 ENG INHEA 0019-8366 CBAC COPYRIGHT: CHEM ABS In dogs inhalation of 1,1,1-trichloroethane (I) [71-55-6] at 200-2000 ppm for 1 h resulted in a marked decrease in the no. of leukocytes; this decrease was max. (61Z) 30 min after exposure 00013768 1,1.1-TRICHLOROETHANE PAGE 18 CAS REGISTRY NUMBER ENTRY MONTH SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE LANGUAGE CODEN ABSTRACT 030392 CAS REGISTRY NUMBER ENTRY MONTH and had recovered to 20'/. lower than control values by 2 h. Ho I-related changes in erythrocyte, blood platelet, or hematocrit were obsd. A dose-response relationship was found at 200-700 ppm. Neutrophil nos. were decreased most, whereas lymphocytes, acidophils, and monocytes increased. Probably, neutrophiIs were not destroyed by I but rather were trapped from the peripheral blood into other tissues. 71-55-6 840*, HEEP/85/02995 HOBARA T KOBAYASHI H HIGASHIHARA E KAWAMOTO T SAKAI T Department of Public Health, Yaraaguchi U-iiversity School of Medicine, 1199 Kogushi, Ube , 755 Japan . Acute effects of 1,1,1-trichloroethane, trichloroethylene and toluene on the hematologic parameters in dogs. ARCH ENVIRON CONTAM TOXICOL! 13 (5). 1989. 589-599. ENG AECTC KEEP COPYRIGHT: BIOL ABS. Mature cross-bred dogs were acutely exposed to 1, 1, 1-trlcbloethane, trichloroethylene and toluene. The changes in hematologic parameters, during and after exposure, were reported. A marked but temporary decrease in leukocytes was noted 30 rain after the initiation of exposure! no changes were observed in erythrocyte counts, hematocrit values or thrombocytes counts with all 3 solvents. The decrease in the amount of neutrophils was particularly prominent. Based upon leukocyte differential counts, all types of leukocytes showed a decrease. The decrease in leukocyte counts was the largest with exposure to trichloroethylene, followed by 1,1,1-trichloroethane and toluene, respectively. A dose-response relationship was noted between exposure concentrations and decreased leukocyte counts, i.e., 1, 1,1-trichloroethane and toluene from 200-700 ppm! trichloroethylene from 0-700 ppm. 103-88-3! 79-01-6! 71-55-6 8502 00013769 1,1,1-TRICHLOROETHANE PAGE 19 28 SECONDARY SOURCE 10 CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE LANGUAGE CODEN INTL STAND SER NO ABSTP *CT CAS REGISTRY NUMBER ENTRY MONTH CA/101/165056Q CA/109003 Hobara T Kobayashi H Higashihara E Kawamoto T Sakai T Sch. d., Yamaguchi Univ., Uba Acute effects of 1,1>l-trichloroethane, trichloroethylene, and toluene on the hematologic parameters In dogs Arch. Environ. Contam. Toxicol.i VOL 13, ISS 5, 1989,589-93 JOURNAL ARTICLE Japan 755 ENG AECTC 0090-9391 CBAC COPYRIGHT: CHEM ABS Mature cross-bred dogs were acutely exposed to 1,1,1-trichloroethane 171-55-6], trichloroethylene [79-01-6] > and toluene [108-88-31. The changes in hematol. parameters, during and after exposure, are reported. A marked but temporary decrease in leukocytes was noted 30 min after the initiation of exposure; no changes were obsd. in erythrocyte counts, hematocrit values, or thrombocyte counts with all 3 solvents. The decrease in the amt. of neutrophils was particularly prominent. Based upon leukocyte differential counts , all types of leukocytes showed a decrease. The decrease in leukocyte counts was the largest with exposure to trichloroethylene, followed by 1>1,1-trlchloroethane and toluene, resp . A dose-response relation was noted between exposure concns. and decreased leukocyte counts, i.e.> 1,1,1-trichloroethane and toluene from 200 to 700 ppmJ Tr i chloroethylene from 0 to 700 p>.m. 71-55-6! 79-01-6! 108-68-3 8912 0001^^ ltltl-TRICHLOROETHANE PAGE 0 29 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE LANGUAGE * C0DEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 30 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE C0DEN ABSTRACT m m # * I! SL 030394 CA/095/181696K Hobara T Kobayashi H Iuamoto S Sakai T Sch. Med., Yamaguchi Univ., Ube Diminution of 1,1,1- and 1,1 ,-trichloroethane in the blood and their excretion by the lung Sangyo Igaku; VOL 3, ISS A, 1981,377-8 JPN SAIGB CBAC COPYRIGHT: CHEH ABS The concn. of I,I>1-trlchloroethane (1,1,1-TCE) in blood was lower than that of 1>1> -trlchloroethane (l)l,-TCEi after i,v. injections to dogs at 100 and 50 mg/kg, resp. (71-55-6 1,111-Trichloroethaneit 79-00-5 1>1>-Trichloroethane ) After 1 min, the level of lltl-TCE was 7-10 times higher than that of 11-TCE in the expired airt but the concn. was not different after 15-Ci0 min of administration. Durinq 1 h after the injection, 61-68 and E1-31X of 1,1,1- and 1,1,-TCE, resp., were excreted from the lung. 71-55-6; 79-00-5 811 HEEP/8E/089EO HOBARA T KOBAYASHI H IUAMOTO S SAKAI T Dep. Public Health, Yamaguchi Univ. Sch. Med., 1199 Kogushi, Ube, 755 Jpn. Diminution of 1,1,1-trichloroethane and 1>1,-trichloroethane in the blood and their excretion by the lunqs. JPN J IND HEALTH; 3 (9). 1981. 377-38E. SAIGB KEEP COPYRIGHT: BIOL ABS. In order to investigate the diminution of 1,1,I-trichloroethane (1,1,1-TCE) and 1,1,-trichloroethane (1,1,2-TCE) in the blood and the excretion by the lungs, 100 mg and 50 mg/kg body ut of 1,1,1-TCE were i.v. administered to 1 and 13 doqs, respectively. and the same amounts of I,1,-TCE to 5 and 8 dogs, respectively. Arterial blood and expired air collected by 60 min after injection were analysed with a FID(flame ionization detector )-gas chromatograph. 1.1,1-TRICHLOROETHANE PAGE SI 4 Concentrations of 1,1,1-TCE in the blood were maintained significantly lower from -60 rain after injection than those of 1,1,2-TCE. While highest concentrations of the solvents in the expired air were found after for k# 1.1.1-TCE ware 7- to 10-fold higher. No significant differences in concentration were seen between both solvents after 15-90 rain of administration in expired air. Ratios of the * amounts expired by the lungs 60 rain after injection to the total were 61-68X for 1.1.1-TCE and 21-32X for 1,1,2-TCE, respectively. Highly significant linear regression was found between the concentration of solvent in the blood and in the expired air for each solvent. m CAS REGISTRY HUMBER 79-00-5! 71-55-6 ENTRY MONTH 8S07 31 SECONDARY SOURCE ID CA/101/I85932N CLASSIFICATION CODE CA/109003 AUTHOR Hougaard K AUTHOR Ingvar M # AUTHOR AUTHOR Wieloch T Siesjoe BK ADDRESS Lab. Exp. Brain Res., Univ. Lund* Lund TITLE Cerebral metabolic and circulatory effects of 1>1*1-trichloroethane* a neurotoxic industrial solvent. 1. Effects on local cerebral glucose consumption and blood flow during acute exposure <# SOURCE Neurochem. Pathol.; VOL S, ISS 1, 1989,39-53 PUBLICATION TYPE JOURNAL ARTICLE COUNTRY Swed. ZIP CODE S-SS1 85 LANGUAGE m CODEN ENG NEPAD INTL STAND SER NO 0739-600X ABSTRACT CBAC COPYRIGHT: CHEM ABS The effects of inhaled 1,1,1-trichloroethane (I) [71-55-61 (3500, 6000, and 7800 ppm) on behavior, local cerebral blood flow, and local cerebral glucose [50-99-73 consumption were studied in awake rats. The effect of the solvent * inhalation on the EEG pattern and local cerebral blood flow was also studied in paralysed animals under N30 analgesia. Exposure of awake animals to 6000 ppm I induced a decrease in motility and exploratory behavior. At 7800 ppm, the rats were clearly ataxic. The local cerebral glucose consumption in 3 brain regions was studied by the [19C3 deoxyglucose technique. SL 030395 m 00013772 1,1,1-TRICH LOROETHANE PAGE 22 CAS REGISTRY NUMBER ENTRY MONTH A decrease was obsd. ranging from 14 to SSV. of control values. The inferior colliculus and substantia nigra displayed the largest redns. In exposed animals. the local cerebral blood flow increased in 11 brain structures by 28-45Z. In animals under N20 analgesia> 7400 ppm I induced a depression of the EEG activity. In these animals, the local cerebral blood flow increased by 12-99/, with a large variability in blood flow between the different structures. Thusi exposure of rats to subanesthetic doses of I induces an increase in cerebral blood flow in spite of a concomitant decrease in glucose consumption and depression of cerebral f unc tion. 50-99-7; 71-55-6 8412 SECONDARY SOURCE ID CLASSIFICATION CODE CIS/84/00184 130 AUTHOR Jones RD AUTHOR Winter DP TITLE Two case reports of deaths on industrial premises attributed to 1i1.1-trichloroethane SOURCE Archives of Environmental Health Jan.-Feb. PUBLICATION TYPE 1983, Vol.38, No.1, p.59-61. 11 ref. JOURNAL ARTICLE LANGUAGE Eng ABSTRACT 2 fatal poisonings resulting from exposure to 1,1,1-trichloroethane are described. They occurred in young men at separate workplaces where the solvent was used as a degreasing agent. Factors common to other cases of poisoning are discussed. Although solvent abuse does not appear to have been a factor in the present cases, it might be in part responsible for the recent trend towards such fatalities. KEYWORDS TRICHLOROETHANE KEYWORDS CHLORINATED HYDROCARBONS KEYWORDS ORGANIC SOLVENTS KEYWORDS ACUTE POISONING m KEYWORDS KEYWORDS CASE STUDY FATALITIES KEYWORDS DEGREASING KEYWORDS ILO m CAS REGISTRY NUMBER ENTRY MONTH 71-55-6 8411 m SL 030396 00 73 1,1,1-TRICHLOROETHANE PA(ST 3 33 SECONDARY SOURCE ID AUTHOR AUTHOR ADDRESS TITLE SOURCE LANGUAGE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 34 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY LANGUAGE CODEN INTL STAND SER NO ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH HEEP/SA/00280 JONES RD WINTER DP Employment Med. Advisory Service> Health) Safety Executive United Kingdom. case reports of deaths on industrial premises attributed to 1)1,1-trichloroethane . ARCH ENVIRON HEALTH! 38 (1). 1983. 59-61. ENG AEHLA HEEP COPYRIGHT: BIOL ABS. Tuio fatal poisonings resulting from exposure to 1,111-trichloroethane were described. Each case occurred at a separate workplace where the solvent was used as a degreasing agent. These cases were considered in light of other 1(1tl-trichloroethane poisonings reported to Her Majesty's Factory Inspectorate l UK). Factors common to these and other incidents were discussed. 71-55-6 8401 CA/096/040075S CA/159002 Khali 1 MA K Rasmussen RA Dep. Environ. Sci.> Oregon Grad. Cent.) Beaverton Decline in the atmospheric accumulation rates of trichlorofluororoethane C F -- 11> > dichlorodifluoromethane (F-12) and trichloroethane J. Air Pollut. Control Assoc.; VOL 31> ISS 12) 1981,1274-5 JOURNAL ARTICLE USA ENG JPCAA 0002-2470 CBAC COPYRIGHT: CHEM ABS Fluorocarbon air pollution trichloroethane;Air pollution By fluorocarbons and trichloroethane, decreasing atm. accumulation rates of;Alkanes Air pollution by, decreasing atm. accumulation rates of Fluoro 71-55-6; 75-71-8; 12797-98-7 8204 SL 030397 1,1,1-TRICHLOROETHANE SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR CIS/69/01393 130 Kobayashi H * TITLE SOURCE A mechanism of sys 1611110 hypotension induced by 1,1,1-trichloroethane inhalation Japanese Journal of Industrial Health 1982, PUBLICATION TYPE Vol.29, No.6, P.6A9-657. Ulus. 27 ref. JOURNAL ARTICLE LANGUAGE Jap ABSTRACT Dogs inhaled various concentrations of 1,1,1-trichloroethane (TCE) with measurement of aortic blood flow and pressure and recording of efferent renal sympathetic nerve activity. In acute experiments the threshold concentration of TCE producing a fall in blood pressure was 0.4-0.5X, and there was a dose-response relationship. Total peripheral vascular resistance (TPR), calculated from the aortic parameters , decreased during inhalation and gradually returned to normal on termination of inhalation. There was a dose-response relationship between this decrease and the TCE concentration. At low concentrations, efferent renal sympathetic nerve activity increased, while at high concentrations it decreased with a marked fall in blood pressure. The systemic hvpotension induced by TCE inhalation in high concentrations may be related to the decrease in TPR and unrelated to the sympathetic nervous system and other neurogenic KEYWORDS KEYWORDS mechanisms. TRICHLOROETHANE BLOOD PRESSURE KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS HYPOTENSION TOXICOLOGY ORGANIC SOLVENTS ANIMAL EXPERIMENTS KIDNEY 0 KEYWORDS KEYWORDS KEYWORDS DOSE-RESPONSE RELATIONSHIP SYMPATHETIC NERVOUS SYSTEM ILO CAS REGISTRY NUMBER 71-55-6 m ENTRY MONTH 6502 0 SL 030398 * % OOW3775 1,1,1-TRICHLOROETHANE PETE 5 SECONDARY SOURCE ID CA/098/108630 CLASSIFICATION CODE CA/104003 AUTHOR Kobayashi H w ADDRESS TITLE Sch. Med. Yamaguchi Univ.( Yamaguchi A mechanism of systemic hypotension induced by 1 *111-trichloroethane inhalation SOURCE Sangyo IgakuJ VOL 4, ISS 6, 198,649-57 PUBLICATION TYPE JOURNAL ARTICLE COUNTRY Japan ZIP CODE 755 LANGUAGE JPN CODEN SAIGB INTL STAND SER NO 0047-1879 ABSTRACT CBAC COPYRIGHT: CHEM ABS The mechanism of 1,1>l-trichloroethane (I) [71-55-63-induced hypotension was studied by hemodynamic and neunoelectrophysiol. methods in dogs. In an acute inhalation expt.. the threshold concn. of If to produce a fall in blood pressure( was 0.4-0.5X in inspired airt with this effect being due to a decrease in total peripheral resistance. The slight hypotension induced by the low concn. of I was inhibited by the transection of vagi and carotis sinus nerve, but the marked hypotension induced by the high concn. of I was not inhibited by the transection. Thus the slight hypotension induced by I may be induced via decreasing sympathetic tonus and the marked hypotension may have no relation to the nervous neurogenic mechanism. m CAS REGISTRY NUMBER ENTRY MONTH 71-55-6 8305 SECONDARY SOURCE ID CIS/83/01956 m CLASSIFICATION CODE AUTHOR 130 Kobayashi H AUTHOR Hobara T AUTHOR Hirota H AUTHOR m AUTHOR Higashihara E Iwamoto S AUTHOR Sakai T TITLE Sensitization of dog myocardium to epinephrine by 1,1,1-trichloroethane SOURCE Japanese Journal of Industrial Health June 198, Vol.4, No.5, p.450-454, Ulus. 10 ref. PUBLICATION TYPE JOURNAL ARTICLE LANGUAGE Jap ABSTRACT Anaesthetised dogs were intravenously injected with 5itg/ml epinephrine (EPN) until bigeminy occurred on the electrocardiogram. Dogs were then exposed to constant 030399 1,1,1-TRICH LOROETHANE 26 KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS CAS REGISTRY NUMBER CAS REGISTRY NUMBER ENTRY MONTH 38 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE LANGUAGE CODEN INTL STAND SER NO ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH concentrations of 1,1,1-trichioroethane (TCE) for constant time periods and again injected with EPN until bigeminy occurred. The EPN dose required to cause bigeminy did not change for concentrations of TCE <4900ppm, but decreased for concentrations >8,500ppra administered for lOmin. Increasing the concentration of tce from 6,900 to 69,000ppm for inhalation per lods increasing from 0.5 to 20min resulted in a gradually decreasing ratio of EPN. A dose-response relationship exists for cardiac sensitisation to EPN after TCE exposure. TRICHLCROETHANE ARRHYTHMIA EPINEPHRINE EXCRETION CARDIOTOXIC EFFECTS ANIMAL EXPERIMENTS DOSE-RESPONSE RELATIONSHIP FIBRILLATION ILO 71-55-6 51-43-4 6411 CA/098/046143Z CA/104003 Kobayashi H Hobara T Hirota H Higashihara E luamoto S SaK. ai T Sch. Med., Yamaguchi Ifni v. . Ube Sensitisation of dog myocardium to epinephrine by 1,1,1-trichloroethane Sangyo Igaku! VOL 24, ISS 5, 1982,450-4 JOURNAL ARTICLE Japan 755 JPN SAIGB 0047-1879 CBAC COPYRIGHT: CHEM ABS 1,1,1-trichloroethane [71-55-61 Inha1ation induced cardiac sensitisation to i.v. epinephrine (I) [51-43-4], 51-43-4! 71-55-6 8303 SL 030*00 00013777 1,1.1-TRICHLOROETHANE PAGE 27 39 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR AUTHOR TITLE SOURCE PUBLICATION TYPE LANGUAGE ABSTRACT KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS CAS REGISTRY NUMBER ENTRY MONTH AO SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE LANGUAGE CODEN SL 030401 CIS/84X00198 130 Kobavashi H H- . a T Hi rot a H Sakai T Neural control of blood pressure following 1,1,1-trichloroethane inhalation! A role of sympathetic nervous system Archives of Environmental Health Mar.-Apr. 1983, Vol.38, No.2, p.93-98. Ulus. 14 ref. JOURNAL ARTICLE Eng In these acute inhalation studies in dogs, the threshold concentration of 1,1,1-trichloroethane (1,1,1-TCE) required to reduce blood pressure (BP) was 0.4-0.5X. There was a dose-response relationship betuien the BP decrease and the 1,1,1-TCE concentration. Renal nerve activity increased and was associated with a slight decrease in BP following inhalation of relatively low concentrations; with higher concentrations, renal nerve activity decreased, with a marked decrease in BP. Systematic hypotension resulting from 1,1,1-TCE inhalation may be under the control of two different reactions of sympathetic nerve activity. TRICHLOROETHANE BLOOD PRESSURE ORGANIC SOLVENTS NEUROTOXIC EFFECTS ANIMAL EXPERIMENTS SYMPATHETIC NERVOUS SYSTEM RENAL DYSFUNCTION ILO 71-55-6 8411 HEEP/84/07120 KOBAYASHI H H0BARA T HIROTA H SAKAI T Dep. Public Health, Yamaguchi Uiiv. Sch. Med., Jpn. Neural control of blood pressure following 1,1,1-trichloroethane inhalation: A role of sympathetic nervous system. ARCH ENVIRON HEALTH; 38 (21. 1963. 93-98. ENG AEHLA 00013778 1,1,1-TRICHLOROETHANE PAGE 8 ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 61 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY LANGUAGE CODEN INTL STAND SER NO ABSTRACT SL 030^02 HEEP COPYRIGHT: BIOL ABS. The effects of 1,1,1-trichloroethane (1,1,1-TCE, an occupational toxicant) inhalation on arterial blood pressure and renal sympathetic nerve activity were investigated in anesthetized dogs. In acute inhalation experiments* the threshold concentration of 1*1*1-TCE required to p- - '.tee a decrease in blood pressure was 0.4-0.5/i in inspired air* a dose-response relationship between the decrease in blood pressure and 1>1*1-TCE concentration which exceeded the threshold level was observed. Renal nerve activity increased and was associated with a slight decrease in blood pressure following inhalation of relatively low concentrations of 1*1*1-TCE. Following inhalation of relatively high concentrations of 1*1>1-TCE* renal nerve activity decreased and was accompanied by a marked decrease in blood pressure. Opposite reactions of renal nerve activity were observed when blood pressure decreased to 70-60 mm Hg following inhalation. Apparently* systemic hypotension resulting from 1>1*1*-TCE inhalation may be controlled by different reactions of sympathetic nerve activity. 71-55-6 6606 CA/099/036029A CA/106003 Kobayashi H Hobara T Hirota H Sakai T Sch. Med., Yamaguchi Univ. Neural control of blood pressure following 1,1,1-trichloroethane inhalation: a role of sympathetic nervous system Arch. Environ. Health; VOL 38* ISS , 1983,93-8 JOURNAL ARTICLE Jap an ENG AEHLA 0003-9896 CBAC COPYRIGHT: CHEM ABS The effects of 1.1.1-trichloroethane (1,1,1-TCE) (71-55-63 inhalation on arterial blood pressure and renal sympathetic nerve activity were investigated in anesthetized dogs. In acute inhalation expts., the threshold concn. of 1.1.1-TCE required to produce a decrease in 00013779 1,1,1-TRICHLOROETHANE PAGE 29 CAS REGISTRY NUMBER ENTRY MONTH 42 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE LANGUAGE CODEN INTL STAND SFR NO ABSTRACT SL 030403 blood pressure was 0.4-0.S'/, in inspired airi moreover, a dose-response relation between the decrease in blood pressure and 1,1,1-TCE concn. which exceeded the threshold level was obsd. In addn.i renal nerve activity was increased and assocd. with a slight decrease in blood pressure following inhalation of relatively low concns. of 1,1,1-TCE . Following inhalation of relatively high concns. of 1,1,1-TCE, however, renal nerve activity decreased and was accompanied by a marked decrease in blood pressure. Opposite reactions of renal nerve activity ware obsd. when blood pressure decreased to 70-80 ram Hg following inhalation. Systemic hypotension resulting from 1,1,1-TCE inhalation may be controlled by 2 different reactions of sympathetic nerve activity. 71-55-6 8309 CA/102/216486K CA/104003 Kobayashi H Hobara T Kawamoto T Higashihara E Sato T Tanaka H Iwamoto S Sakai T Sch. Med.) Yamaguchi Univ.> Ube Effects of ltld-trichloroethane inhalation on respiration and blood gas tension Yamaguchi Igaku! VOL 33, ISS 5, 1984,387-91 JOURNAL ARTICLE Japan 755 JPN YIKUA 0513-1731 CBAC COPYRIGHT: CHEH ABS Changes in respiration and arterial blood gas tension after 1,1,1-trichloroethane (I) 171-55-61 inhalation were investigated in anesthetized dogs. In acute inhalation expts., both an increase in respiratory rate and a decrease in amplitude of respiration were obsd. The threshold concn. of I required to produce an increase in respiratory rate was .apprx.O.7-0.9K In inspired air, and a dose-response relation between the increase in respiratory rate and the concn. of I which 00013780 1,1tl-TRICHLOROETHANE PAGE 30 <# # 030*0* SL CAS REGISTRY HUMBER ENTRY MONTH 43 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE LANGUAGE CODEN INTL STAND SER NO ABSTRACT CAS REGISTRY NUMBER exceeded the threshold level was obsd. Moreover) a transient increase in arterial 0 tension, a decrease in CDS tension, and an increase in pH were obsd. after inhalation of higher concns. of I in spontaneous breathing. However, 0 and C0 tension, and pH remained unchanged after inhalation during artificial breathing. 71-55-6J 124-36-9; 7782-44-7 8507 CA/102/04I096F CA/104003 Kobayashi H Hobara T Kawamoto T Sakai T Sch. Med., Yamaguchi Univ., Ube Peripheral vasodilatation following 1.1.1- trich1oroethane inhalation: peripheral vessels as a site of action Arch. Environ. Health; VOL 39, ISS 4, 1984,294-8 JOURNAL ARTICLE Japan 755 ENG A EH LA 0003-9896 CBAC COPYRIGHT: CHEM ABS The effects of 1.1.1- trichioroethane 11) [71-55-61 inhalation on total peripheral vascular resistance and the possibility of the peripheral vessels being a site of action for I were investigated in anesthetized dogs. In acute inhalation expts., a decrease in total peripheral vascular resistance was obsd. following inhalation of I concns. sufficient to induce systemic hypotension. The threshold concn. of I required to produce a decrease in perfusion pressure of the isolated hindlimb was approx. 0.4-0.5k in inspired air. A dose-response relationship between the decrease in perfusion pressure and I concn., which exceeded the threshold level, was obsd. It is suggested that the decrease in total peripheral vascular resistance is related to systemic hypotension following I inhalation; further , this vasodilator effect may be induced in the peripheral vessels > which is one of the sites where I acts. 71-55-6 00013781 1,1,1-TRICHLOROETHANE PAGE 31 ENTRY MONTH 44 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUii'OR AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE LANGUAGE CODEN INTL STAND SER NO ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 8503 CA/101/205581R CA/104003 Kobayashi H Hobara T Kawamoto T SaK si T Sch. Msd., Yamaguchi Univ., Ube Peripheral vasodilator effect of 1,1,1-trich1oroethane inhalation Sanqyo Igaku; VOL 26, ISS 2, 1984,112-15 JOURNAL ARTICLE Japan 755 JPN SA1GB 0047-1879 CBAC COPYRIGHT: CHEM ABS The right hindlimb of a dog anesthetized with pentobarbital was amputated at the center of thigh bone. Venous blood circulated in the isolated limb was returned to the femoral vein. Changes in perfusion pressure following 1,1,1-trichloroethane (I) [71-55-63 inhalation were the reaction of peripheral vessels only as the site of action of I. In an acute inhalation expt., a fall in perfusion pressure was obsd. following I inhalation and then gradually returned to the preinhalation level. The threshold concn. of I producing the fall in perfusion pressure was .apprx.0.4-0,5V. in inspired air; a dose-response relation was obsd. between the fall in perfusion pressure and the concns. of I. The fall in perfusion pressure resulting from I inhalation at 2.0-3.8k was not affected by pretreatment with atropine (1.0 wg/kg, i . v . ), propranolol (2.0 mg/kg, i.v.3 or phentolamine (1.0 mg/kg, i.v.). Thus, the peripheral vasodilator effect of I as a site of action may be related to systemic hypotension and not to sympathetic and parasympathetic nervous systems. 71-55-6 6501 030405 00013782 w> 1,1,1-TRICHLOROETHANE PAGE 32 45 SECONDARY SOURCE ID BIOSIS/86/06877 AUTHOR KOBAYASHI H AUTHOR HOBARA T AUTHOR KAWAMOTO T AUTHOR SATO T AUTHOR SAKAI T TITLE THE MECHANISM OF RESPIRATORY ARREST FOLLOWING 111 TRICHLOROETHANE INHALATION SOURCE JPN J INO HEALTH; 27 (3). 1985. 170-171. LANGUAGE JPN CODEN SAIGB w ABSTRACT BIOSIS COPYRIGHT: BIOL ABS. RRM APNEA VASODILATION CAS REGISTRY NUMBER 71-55-6 ENTRY MONTH 8604 46 SECONDARY SOURCE ID CA/103/208391F CLASSIFICATION CODE CA/104003 AUTHOR Kobayashi H m AUTHOR AUTHOR Hobara T Kawamoto T AUTHOR Sato T AUTHOR Sakai T m ADDRESS TITLE Sch. Med.i Yamaguchi Univ., Ube The mechanism of respiratory arrest following 1tljl-trichloroethane inhalation SOURCE Sanqyo Igaku; VOL 27, ISS 3, 1985,170-1 m PUBLICATION TYPE COUNTRY JOURNAL ARTICLE Japan ZIP CODE 755 LANGUAGE JPN * COO EH SAIGB INTL STAND SER NO 0047-1879 ABSTRACT CBAC COPYRIGHT: CHEM ABS The effect of 1,1,1-trichloroethane (I) [71-55-61 on respiration was studied in dogs with 2 tubes at a trachea (A:inserted toward pharynx for insufflation of I, B:inserted toward lung for ventilation). When I was insufflated into the upper respiratory tract by tube A, temporary apnea appeared at a concn. of >3.6X. But in animals after superior laryngeal nerve denervation apnea did not appear. Thus, apnea was not due to the anesthetic effeet of I, but to the reflective defensive response. CAS REGISTRY NUMBER 71-55-6 ENTRY MONTH 8601 m 030 M>6 su 1,1,1-TRICHLOROETHANE PAGE SECONDARY SOURCE ID HEEP/82/08421 AUTHOR KOBAYASHI H AUTHOR HOBARA T AUTHOR SAKAI T ADDRESS Dap. of Public Health, Yamaguchi l)niv. Sch. Hed., 1144 Kogushi, Ube, 755 Jpn. TITLE A role of the autonomic nervous system in m alterations of blood pressure and heart rate induced by 1,1,1-trichloroethane. SOURCE JPN J IND HEALTH; 23 <4>. 1981. 401-406. CODEN SA1GB m ABSTRACT HEEP COPYRIGHT: BIOL ABS. An experiment was conducted to clarify effects of 1.1.1-trichloroethane (1,1,1-TCE) on blood pressure and heart rate and to investigate m the role of the autonomic nervous system in these responses. Adult mongrel dogs were anesthetized with sodium pentobarbital (25-30 mg/kg, i.v.) and respiration was maintained # artificially with positive pressure ventilation. 1,1,1-TCE (50 mg/kg) was injected i.v. The left kidney was exposed by flank incision and discharges of efferent <# renal sympathetic nerve were recorded using bipolar platinum electrodes. 1,1,1-TCE induced 39.6 t 3.1/ (mean i SE) diminution in systemic blood pressure compared to each pre-administration level but the blood pressure gradually returned to control level in the vagi intact group. A fall in blood pressure to 39.3 t 5.1/ level was induced by m 1.1.1-TCE in the group bilaterally vagotoinired or treated with atropine, but it was not significantly different from that in the vagi intact group. Immediately after administration of 1,1,1-TCE, heart rate significantly decreased from 122.3 i 9.1 to 86 i 5.6 beats/min in the vagi intact group but remained unchanged in the vagotomy or atropine group. Discharges of efferent renal nerve were augmented and blood pressure fell after injection of nitroqlycerin. Decreased discharge of efferent renal sympathetic nerve and increased blood pressure were observed after injection of norepinephrlne . Discharges decreased despite a fall in blood pressure after administration of 1,1,1-TCE. This response showed that the decrease of efferent renal sympathetic nerve activity was related to the fall in blood pressure after 1.1.1-TCE. The autonomic nervous system may m play a major role in the effects of 1,1,1-TCE # m 00013784 1,1,1-TRlCHLOROETHANE PAGE IP CAS REGISTRY NUMBER W ENTRY MONTH 48 SECONDARY SOURCE ID CLASSIFICATION CODE m AUTHOR AUTHOR AUTHOR ADDRESS m TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE m LANGUAGE CODEN INTL STAND SER NO ABSTRACT m m !* ? C.1, CAS REGISTRY NUMBER ENTRY MONTH SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR TITLE SOURCE PUBLICATION TYPE LANGUAGE CODEN ABSTRACT KEYWORDS KEYWORDS KEYWORDS KEYWORDS 1*0* on blood pressure and heart anesthetized dogs. 71-55-6 8207 rate in CA/097/121609S CA/104003 Koirumi A Kumai M Ikeda M Sch. Med. Tohoku Univ., Sendai In vivo suppression of 1,1,1-trichloroethane metabolism by coadministered tetrachloroethylene' an inhalation study Bull. Environ. Contain. Toxicol ; > V0t 2*9, ISS 2, 1982,196-9 JOURNAL ARTICLE Japan 980 ENG BECTA 0007-4861 CBAC COPYRIGHT: CHEM ABS 1.1.1-trichloroethane Cl) C71-55-61 (350 ppm) metab. in rats was suppressed by tetrachloroethylene (II) (127-18-41 (100 ppm) dramatically, more intensively during inhalation exposure for 8 h and less intensively after termination of the exposure. More predominate suppression of I metab. suggests that eposiJe formation in II metab. may more preferentially occur than I oxidn. when I and II compete for mixed function oxidase system. 71-55-65 76-03-9; 115-20-8; 127-18-4 8211 ETIC/82/003159 LANE RW RIDDLE BL BORZELLECA JF EFFECTS OF 1> 2-DICHLOROETHANE AND 1.1.1-TRICHLOROETHANE IN DRINKING WATER ON REPRODUCTION AND DEVELOPMENT IN MICE TOXICOL APPL PHARMACOL; 63:409-421,1982 Journal Article ENG TXAPA ETIC/ORNL 1,2-DICHLOROETHANE 1,1,1-TRICHLOROETHANE MAMMAL MOUSE % % * <4 000137'' 1,1,1-TRICHLOROETHANE PAGE 35 KEYWORDS MUS KEYWORDS ICR SWISS KEYWORDS B KEYWORDS PRECONCEPTION* KEYWORDS PRECONCEPTION KEYWORDS REPRODUCTIVE TOXICOLOGY KEYWORDS MULTIGENERATION STUDY m KEYWORDS KEYWORDS VIABILITY, FERTI1 HY, AND MORTALITY GROWTH KEYWORDS NERVOUS SYSTEM KEYWORDS CRANIUM AND FACE m KEYWORDS KEYWORDS CARDIOVASCULAR SYSTEM UROGENITAL SYSTEM KEYWORDS MUSCULOSKELETAL SYSTEM CAS REGISTRY ttUMBER 107-06--2; 71-55-6 m ENTRY MONTH 6408 50 SECONDARY SOURCE ID EMIC/82/004683 AUTHOR LANE RW m AUTHOR AUTHOR RIDDLE BL B0R2ELLECA JF TITLE EFFECTS OF 1,2-DICHLOROETHANE AND 1,1,1-TRICHLOROETHANE IN DRINKING WATER ON REPRODUCTION AND DEVELOPMENT IN MICE SOURCE TOXICOL APPL PHARMACOL; 63:409-421,1062 PUBLICATION TYPE Journal Article LANGUAGE ENG CODEN TXAPA ABSTRACT EMIC/ORNL SEE: CA 96-212128 KEYWORDS 1,2-DICH LOROETHANE KEYWORDS 1,1,1-TRICHLOROETHANE m KEYWORDS KEYWORDS MAMMAL,MOUSE MUS KEYWORDS ICR SWISS KEYWORDS MALE m KEYWORDS KEYWORDS FEMALE DOMINANT LETHAL TEST KEYWORDS REPRODUCTIVE PERFORMANCE CAS REGISTRY NUMBER 107-06-2; 71-55-6 ENTRY MONTH 8408 SECONDARY SOURCE ID HEEP/83/05609 AUTHOR LANE RW AUTHOR RIDDLE BL AUTHOR BORZELLECA JF ADDRESS Div. Toxicol., Dep. Pharmacol., Med. Coll. Va., Va. Commonu. Univ.> Richmond, Va. 23298, USA. TITLE Effects of 1,2-dichloroethane and 1,1,1-trichloroethane in drinking water on reproduction and development in mice. m SOURCE CODEN TOXICOL APPL PHARMACOL; 63 (3 >. 1982. 409-421. TXAPA SL 030^09 00013786 1,1,1-TRICHLOROETHANE PAGE 36 ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 52 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR AUTHOR TITLE SOURCE PUBLICATION TYPE LANGUAGE CODEN ABSTRACT KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS SL 030410 HEEP COPYRIGHT: BIOLABS. A multigeneralion reproduction study was modified to include screening for dominant lethal and teratogenic e 'x: ts of 1,2-dichloroethane tl,2-DCE) and l,ltl-trichloroethane (1,1,1-TCE) in drinking solution 1Emulphor:deionised water, 1:99, ''olA'oll. Mala end femala ICR Swij* mica racaNsd aithar 1E-DCE ot concentration* of 0, 0.03, 0.09 or 0.29 mg/ml, or 1,1,1-TCE at concentrations of 0, 0.58, 1.75 or 5.83 wqAnl. These concentrations were designed to yield dally 1,2-DCE doses of 0, 5, 15 or 50 mg/kg and 1,1,1-TCE doses of 0, 100, 300, or 1,000 mg/kg, respectively. No taste aversion was evident for either of the chemicals at any concentration. There appeared to be no dose-dependent effects on fertility, gestation, viability or lactation indices. Pup survival and weight gain were not adversely affected. 1,2-DCE and 1,1,1-TCE failed to produce significant dominant lethal mutations or terata in either of the 2 generations tested. 107-06-2! 71-55-6 6305 EMIC/83/006151 LIPPENS R CLAEYS M WILDEMAUWE C VAN LAREBEKE N MUTAGENICITY STUDIES ON 10 PESTICIDES, ON TRICHLOROETHANE AND ON DIAMINOBENZIDINE MUTAT RES! 113:277-276,1983 MEETING ABSTRACT ENG MURE A EMIC/ORNL MICROSOMES.RAT LIVER,S9 CHL0RT0LUR0N METOBRONURON PROPACHLOR TERBUTRYN BROMOiPHOS-METHYL METHIDATHION PENTACHLOROPHENOL CHLOROBENZIDE FENSON TECNAZENE NAPHTHYL ACETAMIDE 1,1,1-TRICHLOROETHANE 3,3*-DIAMINOBENZIDINE BACTERIA m 00013787 m m KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS CAS REGISTRY NUMBER m ENTRY MONTH 53 SECONDARY SOURCE ID CLASSIFICATION CODE m AUTHOR AUTHOR AUTHOR ADDRESS # TITLE. m SOURCE m PUBLICATION TYPE COUNTRY ZIP CODE # LANGUAGE CODEN INTL STAND SER NO ABSTRACT # m -- m m m CAS REGISTRY NUMBER ENTRY MONTH 54 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR TITLE SOURCE PUBLICATION TYPE 1>1>1-TRICHLOROETHANE PAGE 37 # SALMONELLA TYPHIMURIUM TA9B TA100 TA1535 TA1537 TA153S AMES TEST AROCi1254 15545-48-9! 3060-89-7; 1918-16-7; 886-50-0; 2104-96-3; 950-37-8; 87-86-5; 80-33-6; 117-18-0! 86-86-2; 71-55-6; 91-95-2 8408 CA/099/109916Y CA/159001 Makide Y Yokohata A Tominaga T Fao. Sci.> Univ. Tokyo, Hongo Ultratrace analysis of dichlorodifluoromethane, trichlorofluoromethane > 1,1,2-trichloro-1>2t 2-trifluoroethane, It 1>1-triehloroethane, carbon tetrachloride, trichloroethene, and perchloroethere in the atmosphere J. Trace Microprobe Tech.; VOL 1> ISS 3, 1983,265-92 JOURNAL ARTICLE Japan 113 ENG JTMTD 0733-4680 CBAC COPYRIGHT: CHEM ABS Halocarbon detn air gas chromatog Chlorofluoromethane detn air gas chromatog;Air analysis Halogenated methanes and ethanes and ethenes detn. in, gas chromatog. 56-23-5; 67-72-1; 71-55-6; 75-69-4; 75-71-8,* 76-13-1; 79-01-6 8310 CIS/84/01982 130 McCarthy TB Jones R0 Industrial gassing poisonings due to tr i chloreth'<lene , perchlorethylene , and 1-1-1 trichloroethane, 1961-60 British Journal of Industrial Medicine Nov. 1933, Vo1.40, No.4, p.450-455. Illus. 16 ref. JOURNAL ARTICLE AOO M 1 00013768 1,1,1-TRICHLOROETHANE PAGE 38 LANGUAGE Eng ABSTRACT An analysis of 330 gassing incidents in the (Ati ted Kingdom) involving 384 people. There vj were 17 fatalities and 168 cases of unconsciousness. Toxic effects were mostly on the central nervous system) with gastrointestinal and respiratory symptoms W also quite common. Only 4 cases of slight hepatic dysfunction were noted) with no conclusive evidence of hepatotoxicity. In 9 case reports deliberate solvent abuse was a causative factor) 7 of the victims being from W the 15-19 years age group. It is suggested that supervisory staff be made constantly aware of the possibility of drug abuse among young workers. KEYWORDS CHLORINATED HYDROCARBONS KEYWORDS ORGANIC SOLVENTS KEYWORDS TOXIC GASES KEYWORDS ACUTE POISONING KEYWORDS UNITED KINGDOM KEYWORDS HEPATOTOXIC EFFECTS KEYWORDS FATALITIES KEYWORDS CENTRAL NERVOUS SYSTEM KEYWORDS YOUNG PERSONS KEYWORDS UNCONSCIOUSNESS KEYWORDS DRUG DEPENDENCE KEYWORDS ILO CAS REGISTRY NUMBER 79-01-6 CAS REGISTRY NUMBER 71-55-6 CAS REGISTRY NUMBER 127-16-4 ENTRY MONTH 8502 55 SECONDARY SOURCE ID CA/104/001873Q CLASSIFICATION CODE CA/104003 AUTHOR Mochida K AUTHOR. Salto K ADDRESS Shi mane Prefect. Inst. Public Health Environ. Sci.> Nishihamasada TITLE Toxicity assessment of tetrachloroethylene, trichloroethylene and 1>1>1-tr i chloroethane using human and monkey cells SOURCE Bull. Environ. Contarn. Toxicol.; VOL 35> ISS * 5, 1985,593-5 PUBLICATION TYPE JOURNAL ARTICLE COUNTRY Japan ZIP CODE 690-01 LANGUAGE ENG CODEN BECTA INTL STAND SER NO 0007-4861 ABSTRACT CBAC COPYRIGHT: CHEM ABS In the toxicity of tetrachloroethylene [127-18-41 , trichloroethylene [79-01-6], and 00013789 1,1,1-TRICHLOROETHANE PAGE 39 CAS REGISTRY NUMBER ENTRY MONTH 56 SECONDARY SOURCE ID AUTHOR AUTHOR TITLE SOURCE LANGUAGE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 57 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE LANGUAGE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 58 SECONDARY SOURCE 10 CLASSIFICATION CODE AUTHOR ADDRESS TITLE SOURCE 030*1-3 1,1(1-trichloroethane t71-55-6] to human (KB) and monkey (AGMK) cells, using 1050 as an index of toxicity, there was no clear distinction in sensitivity between KB and AGMK cells. Tetrachloroethylene was more toxic than the other 2 haloethanes to KB and AGMK cells. 71-55-6; 79-01-6; 127-18-9 860E BIOSIS/86/10099 MOCHIDA K SAITO K TOXICITY ASSESSMENT OF TETRACHLOROETHYLENE TRICHLOROETHYLENE AND 1 1 1 TRICHLOROETHANE USING HUMAN AND MONKEY CELLS BULL ENVIRON CONTAM TOXICOL*, 35 (5). 1985. 593-595. ENG BECTA BIOSIS COPYRIGHT: BIOL ABS. RRM CYTOTOXICITY 127-18-9; 79-01-6; 71-55-6 6609 CA/101/135958T CA/159000 Mons t er AC Coronel Lab., Lkiiv. Amsterdam, Amsterdam 1,1,1-Trichloroethane [and environmental monitorinq] Biol. Monit. Survei11. Work. Exposed Chem., [Proc. Int. Course] J 1989,191-50 MONOGRAPH Neth. NL-1005 GA ENG 52BPA CBAC COPYRIGHT: CHEM ABS Review trichloroethane health hazard occupational ;Health hazard Of trichloroethane exposure Occupational 71-55-6 8911 CA/099/170933T CA/109003 Moser VC Med. Coll. Virginia, Virginia Commonw. Univ., Richmond A comparative behavioral pharmacology of inhaled solvents; toluene, 1,1,1-trichloroethane, halothane, and ethanol Diss. Abstr. Int. B 1983, 99(3), 766; # 00013790 m 1,1,1-TRICHLOROETHANE PAGE 40 1983,178 pp! PUBLICATION TYPE THESIS COUNTRY USA LANGUAGE ENG COB rN DABBB ABSiRACT CBAC COPYRIGHT: CHEM ABS A disser. Behavior effect org solvent Toluene behavior effect Trlchloroethane behavior effect Halothane behavior effect Ethanol behavior effect CAS REGISTRY NUMBER 64-17-5; 71-55-6; 106-88-3; 151-67-7 ENTRY MONTH w 8312 59 SECONDARY SOURCE ID CA/102/126849B CLASSIFICATION COOE CA/104003 AUTHOR Moser VC AUTHOR Balster RL ADDRESS Med. Coll. Virginia, Virginia Commonw. Univ., Richmond TITLE Acute motor and lethal effects of inhaled toluene, 1,1,1-trichloroethane, halothane, and ethanol in mice: effects of exposure duration SOURCE Toxicol. Appl. Pharmacol.; VOL 77, ISS 2, 1985,285-91 PUBLICATION TYPE JOURNAL ARTICLE COUNTRY USA ZIP CODE t9 LANGUAGE 23298 ENG CODEN TXAPA INTL STAND SER NO 0041-008X ABSTRACT Wy CBAC COPYRIGHT: CHEM ABS Some acute effects of inhalation exposure to toluene [108-88-3], 1,1,1-trichloroethane (1,1,1-TCEJ [71-55-6], halothane [151-67-7], and EtOH t [64-17-51 were examd. in mice. Lethality and performance on an inverted screen test of motor performance were measured following 10, 30, and 60 min exposures. Concn.-dependent effects were obtained on both measures for all solvents except that lethal concns. of EtOH could not be produced under these exposure conditions. Lethality increased wit[h longer exposures for toluene, 1,1,1-TCE, and halothane. Sensitivity to the motor * effects of 1,1,1-TCE, halothane, and EtOH increased when exposure duration was increased from 10 to 30 min, with no further change with 60 inin exposures. In contrast, * behavioral sensitivity to Toluene increased over the entire range of exposure durations. The relative lipid solubilities of the SL 030*14 solvents correlate with potency for i 00013791 1,1,1-TRICHLOROETHANE PAGE 41 CAS REGISTRY NUMBER ENTRY MONTH 60 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE LANGUAGE CODEN ABSTRACT SL 030415 behavioral activity but not as well with potency for lethality. The ratio of potency for motor and lethal effects depended on the chem. studied and in some cases exposure duration. Thus> both concn. and exposure duration det. the effects of inhaled compds . but a simple linear relation does not exist and it depends upon the effect measured. 64-17-5; 71-55-6; 103-88-3; 151-67-7 6505 BIOSIS/65/02816 MOSER VC SCIMECA JA BALSTER RL Dep. Pharmacology and Toxicology* Med. College Virginia> Virginia Commonwealth Oiiv., Box 613* MCV Station* Richmond* Virginia 23298. Minimal tolerance to the effects of 1 * 1*1-trichloroethane on fixed-ratio respondina in mice. NEUROTOXICOLOGY (LITTLE ROCK); 6 (1). 1965. 35-42. ENG NRTXD BIOSIS COPYRIGHT: BIOL ABS. Most laboratory anlmal studies of the behavioral or neurophysiological effects of repeated exposures to volatile organic solvents find little evidence for substantial tolerance. The development of tolerance to the effects of 1>1>1-trichloroethane (1>1>1-TCE) on fixed-ratio responding was examined in 4 mice. The subjects were exposed to 6000 ppm solvent vapor for 20 min of the daily 45-min operant sessions. Once a wk* a series of 4 concentrations (1000-8000 ppm) were substituted for the daily exposure to obtain a cumulative concentration-effect curve. This proved to be a rapid and relieable method with which to ascertain the effects of l.lil-TCE over a range.of concentrations. During the 15 days of 20-min exposure* the subjects showed a slight but significant increase in both response rates during exposure and in the rate of recovery following exposure. Maximal changes in these measures were evident in the first 7 days* with no further decreased sensitivity over the final 8 days of exposure. The concentration-effect curves determined during and after the daily exposures showed no 00013792 1,1,1-TRICHL0R0ETHANE PAGE 92 significant shifts in either direction from the initial curve. Thus, while some alteration in the daily acute effects was t,,4) noted, this tolerance was not of large magnitude and could not be detected as a change in the concentration-effect curve. CAS REGISTRY HUMBER 71-55-6 ENTRY MONTH 8509 61 SECONDARY SOURCE ID CA/10 3/017939F CLASSIFICATION CODE CA/109003 AUTHOR Moser VC AUTHOR Scimeca JA AUTHOR Balster RL ADDR ESS Med. Coll, Virginia, Virginia Commonu. Univ., Richmond TITLE Minimal tolerance to the effects of I > 1,1-trichloroethane on fixed-ratio responding in mice 1 SOURCE PUBLICATION TYPE Neurotoxicoloqy; VOL 6, ISS 1, 1985,35-92 JOURNAL ARTICLE COUNTRY USA ZIP CODE 23298 LANGUAGE W CODEN ENG NRTXO INTL STAND SER NO 0161-813X ABSTRACT CBAC COPYRIGHT: CHEM ABS The development of tolerance to the effects of W 1,1,1-trichloroethane (1,1,1-TCE) (71-55-63 on fixed-ratio responding in mice was studied. The subjects were exposed to 6000 i J ppm solvent vapor for 20 min of the daily 95-min operant sessions. Once a week, a series of 9 concns. (1000-8000 ppm) were substituted for the daily exposure to obtain a cumulative concn.-effect curve. This proved to be a rapid and reliable method with which to ascertain the effects of 1,1,1-TCE over a range of concns. During the 15 days of 20-min exposure, the subjects showed a slight but significant increase in both response rates during exposure and in the rate of recovery following exposure. Maximal changes in these measures were evident in the 1st 7 days, with no further decreased * sensitivity over the final 8.days of exposure. The concn.-effect curves detd. during and after the daily exposures showed no significant shifts in either direction from the initial curve. Thus, whereas some alteration in the daily acute effects was noted, this tolerance was not of large qnitude and could not be detected as a * ) m 00015793 1>1.1-TR ICH LOROETH ANE PAGE 93 CAS REGISTRY NUMBER ENTRY MONTH 62 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE LANGUAGE CODEN INTL STAND SER ABSTRACT SL 030417 CAS REGISTRY NUMBER ENTRY MONTH change in the concn.-effect curve. 71-5S-6 8508 CA/097/121616S CA/109003 Mull in LS Krivanek ND Haskell Lab. Toxicol. Ind. Med., E. I. du Pont de Nemours and Co., Newark Comparison of unconditioned reflex and conditioned avoidance tests in rats exposed by inhalation to carbon monoxide, 1,1,1-trichloroethane, toluene or ethanol Neurotoxicology; VOL 3, ISS 1, 1982,126-37 JOURNAL ARTICLE USA 19711 ENG NRTXD 0161-613X CBAC COPYRIGHT: CHEM ABS The sensitivity of unconditioned reflex and conditioned avoidance tests in evaluating behavioral toxicity was compared. Male rats were exposed by inhalation up to 9 h to 0-1600 ppm CO, 0-12,000 ppm 1,1,1-trlchloroethane [71-55-6], 0-6900 ppm PhMe [103-88-31, or 0-32,000 ppm EtOH [69-17-51. Animals were tested for behavioral chances at 0.5-9 h during exposure and 18 h a-ter the exposure ended. In unconditioned reflex testing, the presence or absence of specific unconditioned reflexes (such as corneal, placing, grasping, and righting reflexes) and simple behavior patterns including locomotor activity and coordination were obsd. The conditioned reflex task consisted of shock avoidance by le'ier press following simultaneous light and sound stimuli. Rats began to fail unconditioned reflex tests at 800 ppm CO, 3000 ppm trichloroethane, 800 ppm PhMe, and 8000 ppm EtOH. Decrements in conditioned avoidance were obsd. at 800 ppm CO, 6000 ppm trichloroethane, 3200 ppm PhMe, and 8000 ppm EtOH. Neither test was consistently more sensitive than the other in detecting behavioral changes. For both methods, the concns. at which changes were detected in rats were 2-10-fold higher than those reported for human effects. 69-17-5! 71-55-6! 108-88-3! 630-08-0 8211 000137'!'. m 1,1,1-TRICH LOROETHANE PAGE 99 >j 63 SECONDARY SOURCE ID EMIC/89/052887 AUTHOR NESTMANN ER AUTHOR OTSON R AUTHOR KOWBEL DJ AUTHOR BOTHWELL PD AUTHOR HARRINGTON TR TITLE MUTAGENICITY IN A MODIFIED SALMONELLA ASSAY OF FABRIC-PROTECT !''G PRODUCTS CONTAINING 1.1.1- TRICHLOROEINANE SOURCE ENVIRON MUTAGENESIS; 6:71-60,1984 PUBLICATION TYPE Journal Article * ,i LANGUAGE CODEN ENG ENHUD ABSTRACT EMIC/ORNL KEYWORDS GM,AMES TEST U KEYWORDS KEYWORDS FABRIC PROTECTOR SPRAY 1.1.1- TRICHLOROETHANE KEYWORDS P-DIOXANE KEYWORDS PETROLEUM DISTILLATE KEYWORDS VjS> KEYWORDS MNNG 2-AMINOANTHRACENE KEYWORDS 2-NITROFLUORENE KEYWORDS MICROSOMES,RAT LIVER,S9 KEYWORDS 9-AMINOACRIDINE KEYWORDS AROCLOR 1259 KEYWORDS BACTERIA KEYWORDS SALMONELLA TYPHIMURIUM,TA98 KEYWORDS SALMONELLA TYPHIMURIUM,TA100 KEYWORDS SALMONELLA TYPHIMURIUM,TA1535 KEYWORDS SALMONELLA TYPHINURIUN,TA1537 KEYWORDS SALMONELLA TYPHIMURIUM,TA1538 CAS REGISTRY NUMBER 71-55-6; 123-91-1; 70-25-7; 613-13-8; 607-57-8! 90-95-9 ENTRY MONTH 8603 69 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE LANGUAGE CODEN CA/100/152300U CA/109006 Nest mam ER Otson R Kowbel DJ Bothwell PD Harrington TR Environ. Health Cent., Ottawa Mutagenicity in a modified Salmonella assay of fabric-protecting products containing 1,1,1-trichloroethane Environ. Mutagen.; VOL 6, ISS 1, 1989,71-80 JOURNAL ARTICLE Can. K1A 0L2 ENG ENMUD SL 030418 * 00013795 1, 1>1-TRICHLOROETHANE PAGE 95 * INTL STAND SER NO 0192-2521 ABSTRACT CBAC COPYRIGHT: CHEM ABS Me chloroform (1>1>1-trichloroethane) [71-55-6] was id-ntifled as a major component in 2 fabric-protector spray products. Mutagenic effects ware detd. at several dosage levels for the 2 products and some of the identified components. Levels of orgs. in the air of sealed desiccators, used as exposure chambers in modified Salmonella reversion assays, were measured by a gas chromatog. technique. Both fabric protectors and 2 samples of trichloroethane were mutagenic in strain TA1535 and 1 of each was mutagenic in strain TA100. Other constituents, such as petroleum distillate and p-dioxane 1123-91-1], were nonmutagenic at the tested exposure levels. CAS REGISTRY NUMBER 71-55-6] 123-91-1 ENTRY MONTH 8905 65 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR TITLE SOURCE PUBLICATION TYPE LANGUAGE CDDEN ABSTRACT KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS CAS REGISTRY NUMBER ENTRY MONTH EMIC/82/005993 NESTMANN ER DTSON R KOWBEL DJ BOTHWELL PD HARRINGTON TR MUTAGENICITY OF FABRIC-PROTECTING PRODUCTS CONTAINING 1,1,1-TRICHLOROETHANE IN A MODIFIED SALMONELLA ASSAY ENVIRON MUTAGENESIS; 9:912-913,1982 MEETING ABSTRACT ENG ENMUD EMIC/ORNL 1,1,1-TRICHLOROETHANE FABRIC-PROTECTING COMPOUNDS BACTERIA SALMONELLA TYPHIMURIUM TA100 TA1535 AMES TEST 71-55-6 8903 6o SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS CA/101/I29936V CA/109003 Nolan RJ Freshour NL Rick DL McCarty LP Saunders JH H and ES, Toxicol. Midland Res. Lab., Dow Chem. Co., , SL 030419 00013796 & 1,1,1 -TRICH LOROETHANE PAGE 96 TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE LANGUAGE CODEN INTL STAND SER NO ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 67 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE Q30A20 Kinetics and metabolism of inhaled methyl chloroform (1,1,1-trichloroethane) in male volunteers Fundam. Appl. Toxicol.; VOL 9, ISS 9, 1939,659-62 JOURNAL ARTICLE USA 9369' ENG FAATD 0272-0590 CBAC COPYRIGHT: CHEM ABS The kinetics of inhaled Me chloroform (MC) E71-55-6] and its principal metabolites, trichloroethanol (TCE) [115-20-81 and TCA [76-03-9] , were "defined-"' in 6 healthy male volunteers following single 6-h exposures of 350 and 35 ppm. Blood and expired air MC concns. were proportional to the exposure concn. and indicated that .apprx.25/i of the MC inhaled during the 6-h exposure was absorbed. Elimination of MC was triexponential with half-lives estd. as 99 min, 5.7 h, and 53 h for the initial, intermediate, and terminal phases, resp. Over 91 Ji of the absorbed MC was excreted unchanged via the lungs, 5-6'/. was metabolised and excreted as TCE and TCA, and <lk! remained in the body after 9 days. Urinary TCE and TCA excretion was extremely variable and indicated that urinary TCE and TCA measurements provide at best only a rough est. of the exposure. Apparently, the kinetics of MC in human is essentially 1st order at or below the current treshold limit value of 350 ppm. Based on a comparison of the blood MC levels and amts, of MC metabolised, the rat is a better model than the mouse to predict the toxicity of MC in man. 71-55-6; 76-03-9! 115-20-8 6911 BIOSIS/85/08669 NOLAN RJ FRESHOUR NL RICK DL MCCARTY LP SAUNDERS JH H and ES, Toxicology Research Lab., Dow Chem. Co., 1803 Build., Midland, Michigan 98690. Kinetics and metabolism of inhaled me thy1ehloroform (1,1,1-trichloroethane) in male volunteers. I 00013797 1,1,1-TRICHLOROETHANE PAGE 47 SOURCE LANGUAGE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 68 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOP ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE LANGUAGE CODEN INTL STAND SER NO ABSTRACT SL 030421 FUNDAM APPL TOXICOL} A (A). 1984 CRECD. 1985). 654-662. ENG FAATD BIOSIS COPYRIGHT; BIOL ABS. The kinetics of inhaled methyl chloroform tMC) (an industrial solvent) and its principal metabolites) trichloroethanol (TCE) and trichloroacetic acid (TCA) > were defined in 6 healthy male volunteers following single 6-h exposures of 350 and 35 ppm. Blood and expired air MC concentrations were proportional to the exposure concentration> and indicated thatsorbed. Elimination of MC was Triexponentiali with half-lives estimated as 44 min> 5.7 h and 53 h for the initial) intermediate and terminal phases. Over 91X of the absorbed MC was excreted unchanged via the lungsi 5-6X was metabolized and excreted as TCE and TCA and < IX remained in the body after 9 days. Urinary TCE and TCA excretion was extremely variable, and indicated that urinary TCE and TCA measurements providet at bestt only a rough estimate of the exposure. The kinetics of MC in man are essentially 1st order at or below the current TLV ftheshold limit value) of 350 ppm. Bas on a comparison of the blood MC levels and amounts of MC metabolized) the rat is a better model than the mouse to predict the toxicity of MC in man. 115-20-8} 76-03-9} 71-55-6 6511 CA/103/128292J CA/159002 Okouchi S Coll. Eng., Hosei Univ.> Koganei Volatilization rates of ti'i chloroethylene > lili1-trichi oroethane> and tetrachloroethylene from an aqueous solution to the atmosphere Nippon Kagaku Kaishi; ISS 7> 1965.1483-7 JOURNAL ARTICLE Japan 184 JPN NKAKB 0369-4577 CBAC COPYRIGHT: CHEM ABS Chloroethylene volatilization soln atm Chioroethane volatilization soln atm}Air pollution By chloroethenes and chloroethane> 00013793 1,1,1-TRICHLOROETHANE PAGE 98 'J volatilisation from aq. phase in relation to, photoionisation detection of;Mass transfer Of chloroethane and chloroethene from aq. phase to atm., volatilization rates for yj CAS REGISTRY NUMBER 71-55-6; 79-01-6J 127-18-9 ENTRY MONTH 8511 69 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY 'ZIP CODE LANGUAGE CODEN INTL STAND SER NO ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH CA/100/199203Z CA/159002 Otson R Williams DT Bothuell PD Bur. Chew. Hazards, Health Welfare Canada, Ottawa Fabric protectors. Part II - Propaner 1,1,1-trichloroethane, and petroleum distillates levels in air after application of fabric protectors Am. Ind. Hyg. Assoc. J.i VOL 95, ISS 1, 1989,28-33 JOURNAL ARTICLE Can. K1A 0L2 ENG AIHAA 0002-8699 CBAC COPYRIGHT: CHEM ABS Fabric protector air pollution residence Propane fabric protector air pollution Trichloroethane fabric protector air pollution Petroleum distillate fabric protector pollution Ventilation fabric protector pollution restdence;Air pollution By propane and trichloroethane and petroleum distillates, from aerosol-type fabric protector use, ventilation in relation to Indoor;Coating process Of fabrics, with protective agents, indoor air pollution by org. vapors from, ventilation in relation toiPetroleum products Air pollution by, indoor, from aerosol-type fabric protector use, ventilation in relation to Di st i llates ,`Sol lproofing Of textiles, with fabric protectors, org. vapors from, air pollution by, ventilation in relation totTextiles Fabric protector application to, indoor air pollution by org. vapors from;Ventilation Air pollution by org. vapors from fabric protector use in relation to, in residencestWaterproofing Of textiles, with fabric protectors, org. vapors from, air pollution by, ventilation in relation to 71-55-6; 79-98-6 8905 Ik % '* SL 030422 4 19 00013799 1,1,1-TRICHL0R0ETHANE PAGE 49 70 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR At'OO rss TITLE SOURCE LANGUAGE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE sL 030423 HEEP/84/09791 OTSON R WILLIAMS DT BOTHWELL PD Bur. Chein. Haaards , Environ. Health Directorate Health Welfare Can., Ottawa, Ont. K1A OLE, Can. Fabric protectors! 2. Propane, 1,1,1-trichloroethane and petroleum distillates levels in air after application of fabric protectors. AM IND HYG ASSOC J; 45 (1). 1984. 8-33. ENG AIHAA HEEP COPYRIGHT! BIOL AB5. Propane, 1,1,1-trichloroethane and petroleum distillates levels in air, which were generated during the use of aerosol type fabric protectors, were monitored by the NIOSH (USA National Institute for Occupational Safety and Health) charcoal tube, a glass bulb grab sampling and the GASBADGE passive device techniques. Although 198 ACGIH (American Conference of Governmental Industrial Hygienists) TLV (threshold limit value)-STEL (short-term exposure level) were readily exceeded in an unventilated test room, when fabric was sprayed with 450 g fabric protector in an unconfined area within a home, the generated vapors quickly dispersed and STEL and 8 h TWA( time-weighted average )-TLV were not exceeded. 6002-05-9; 74-96-6) 71-55-6 8408 CA/099/199785G CA/159002 Prinn RG Rasmussen RA Simmonds PG Alyea FN Cunnold DM Lane BC Cardelino CA Crawford AJ Dep. Earth, Atmos. Planet. Sci., Massachusetts Inst. Technol., Cambridge The Atmospheric Lifetime Experiment. 5. Results for 1,1,1-trichloroethane based on three years of data JGR, J. Gecphys. Res., (Sect.) CJ VOL 88, ISS il 3 00013600 0 1,1.1-TRICHLOROETHANE PAGE 50 .1 13, 1933,6415-26 PUBLICATION TYPE JOURNAL ARTICLE COUNTRY USA ZIP CODE '-Jt LANGUAGE 02139 ENG CODEN JJGAD INTL STAND SER NO 0196-2256 ABSTRACT CBAC COPYRIGHT: CHEM ABS Chloroethane atm global av lifetime;Air pollution By trichloroethane, global av. lifetime of, modeling ofJProcess simulation Of trichloroethane air pollution global av. 1ifetime Physicochemical CAS REGISTRY NUMBER 71-55-6 _____ ENTRY MONTH 6312 u 72 SECONDARY SOURCE ID CA/095/043327A AUTHOR Reid KJ AUTHOR ADDRESS Young FJ Dep. Pathol., Univ. Birminoham, Birmingham TITLE Are trichloroethane-based substitutes safer than xylene? SOURCE Med. Lab. Sci.; VOL 38, ISS 2, 1961,145-6 LANGUAGE ENG CODEN MLASD ABSTRACT CBAC COPYRIGHT: CHEM ABS A polemic. The substitution of CH3CC13 based products, such as Inhibisol and CNP30, for xylene and propylene oxide in chem. anals. because the products are nonflammable as stated by M. H. Maxwell (ibid. 1973 35, 401-03) was inaccurate. Maxwell did not evaluate the threshold limit values in their proper context. The relative tox(cities, evapn. rates, required ventilation, and volatilities of the reagents and their substitutes were not adequately considered by Maxwell and are given here. The formation of lethal substances under normal working conditions, such as the heating of CH3CC13 causing the formation of poisonous phosgene gas, were not * considered in the article. CH3CC13 is the major constituent released from CNP30 to the atm1, not C2C16 as Maxwell implied. CAS REGISTRY NUMBER 71-55-6; 75-44-5; 75-56-9; 1330-20-7; 69191-30-6 ENTRY MONTH 8109 030^24 SL 4 t 00013601 1,1,1-TRICHLOROETHANE PAGE 51 73 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR TITLE SOURCE PUBLICATION TYPE LANGUAGE CODEN ABSTRACT KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS CAS REGISTRY NUMBER ENTRY MONTH SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE LANGUAGE CODEN INTL STAND SER NO ABSTRACT 030**25 EMIC/B1/001547 RIDDLE BL CARCHMAN RA BORZELLECA JF EFFECTS OF 1,2-DICHLOROETHANE AND 1,1,1-TRICHLOROETHANE IN DRINKING WATER ON REPRODUCTION AND DEVELOPMENT IN MICE THE TOXICOL; 1:26,1981 MEETING ABSTRACT ENG 00134 EMIC/ORNL 1,2-DICHLOROETHANE 1,1,1-TRICHLOROETHANE MAMMAL,MOUSE MUS ICR SWISS MALE FEMALE REPRODUCTIVE PERFORMANCE 107-06-2; 71-55-6 6406 CA/104/143423S CA/104003 Rosengren LE Aurell A Kjellstrand P Haglid KG Inst. Neurobiol., Univ. Goeteborg, Goeteborg Astrogliosis in the cerebral cortex of gerbiIs after long-term exposure to 1.1.1-trichioroethane Scand. J. Work, Environ. Health; VOL 11, ISS 6, 1965,447-55 JOURNAL ARTICLE Sued. S-400 33 ENG SWEHD 0355-3140 CBAC COPYRIGHT: CHEM ABS Mongolian gerbiIs (Heriones unglculatus ) were continuously exposed by inhalation to 1.1.1-trichloroethane [71-55-63 at 70, 210, or 1000 ppm for 3 mo, followed by a 4-mo post exposure solvent-free period. Concns . of 2 astroglial proteins, S-100 and glial fibrillary acidic (GFA) protein, were then detd. in different regions of the cerebral cortex. The main biochem. alterations induced after exposure to 210 and 1000 ppm of 000X3302 1,1,1-TRICH LOROETHANE PAGE 52 1,1>l-trichloroethane demonstrated a pronounced change in gerbil brain! increased concns. of GFA protein were found in the cerebral sensorimotor cortex at both these exposure levels , an occurrence indicating astrogliosis in this brain region. These results suggest that 1,1>l-trichloroethane should not be regarded as harmless, w particularly regarding neurotoxicity, as previously claimed. CAS REGISTRY NUMBER 71-55-6 ENTRY MONTH 8605 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE LANGUAGE CODEN INIL STAND SER NO ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH CA/097/050330U CA/104033 Savolainen K Ri ihlmaki V Laine A Kekoni J Dep. Pharmacol., Univ. Helsinki, Helsinki Short-term exposure of human subjects to in-xylene and 1,1,1-tr i chloroethane Arch. Toxicol., Suppl.) VOL 5,, 1982,96-9 JOURNAL ARTICLE Finland 00170/17 ENG ATSUD 0171-9750 CBAC COPYRIGHT: CHEM ABS Inhalation exposure of male volunteers to m-xylene (I) [108-33-3) i6.2 mumol/L, 200 ppm) and 1,1,1-trichloroethane (TCE ) [71-55-6] (8.2 and 16.4 mumol/L, 200 and 400 ppm), as well as to a combination of TCE (16.4 muraol/L) and xylene (8.2 mumol/L), induced only slight changes in psychophysiol, functions such as body sway and reaction time. Exposure to the 8.2 mumol/L concn. of I or TCE tended to improve the performances, whereas TCE exposure at 16.4 mumol/L alone or in combination with I tended to have an opposite effect. These results suggest a biphasic acute effect of TCE on the central nervous system (CNS), and reveal that I and TCE together exhibit neither kinetic interaction nor synergistic nor antagonistic acute effects on the CNS functions studied. 71-55-6; 108-33-3 3209 sIj O30^6 00013S0? 1,1i1-TRICHLOROETHANE PAGE 53 76 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 77 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE SL 030427 HEEP/82/07513 SAVOLAINEN K RIIHIMAKI V LAINE A KEKONI J Dep. Pharmacol.) Univ. Helsinki) Sihavuorenpenger 10A> SF-00170 Helsinki 17> Fi nl. Short-term exposure of human subjects to m-xylene and 1.1>l-trichloroethane. INT ARCH OCCUP ENVIRON HEALTH; 49 (1). 1981. 89-98. IAOHD HEEP COPYRIGHT: BIOL ABS. Nine healthy male students were exposed to singular atmospheric concentrations of ro-xylene tan industrial solvent; 8.2 mumol/1; 200 ppm) or 1)1>l-trichloroethane tTCE; 8.2 and 16.4 mumol/1; 200 and 400 ppm) and to a combination of xylene (8.2 mumol/1) and TCE (16.4 mumol/1) for 4 h/day at 6-day intervals. The effects of the atmospheric xylene and TCE concentrations on psycho physiological functions such as reaction time) body balance and CFF (critical flicker fusion) thresholds were studied. The exposures to xylene alone and to the lower TCE concentrations improved the performancesJ higher TCE concentration alone or in combination with xylene had an opposite effect) although statistically significant changes in perform-tee were rare. Results suggested a biphaslc effect of TCE on the CHS> a slight stimulation of the CNS at lower and depression at higher TCE concentrations. Xylene and TCE together exhibited neither kinetic interaction nor synergistic or antagonistic effects on the CNS functions studied. 108-38-3; 71-55-6 8206 CA/097/050819X CA/104003 Schumann AM Fox TR Watanabe PG Toxicol. Res. Lab.> Dow Chem. USA> Midland A comparison of the fate of inhaled methyl chloroform (1>1)l-trichloroethane ) following single or repeated exposure in rats and mice Fundam. Appl. Toxicol.; VOL 2> ISS 1> 00013806 1,1,1-TRICHLOROETHANE PAGE 56 1982,27-32 PUBLICATION TYPE JOURNAL ARTICLE COUNTRY USA ZIP CODE A1' . r> LANGUAGE ENG CODEN FAATD INIL STAND SCR NO o:;s-o59t> ABSTRACT CBAC COPYRIGHT: CHEM ABS Male rata and inice were exposed by inhalation To 1500 ppm methyl chloroform tMC) [71-55-6] 6 h/day, 5 days/wk for .opprx.16 mo. On the last,day of u repeated exposure, ISC-labeled MC was used. The fate of the [ISC]MC in the repeatedly exposed animals was compared to a group of rats and mice which were exposed concurrently for 16 mo to chamber air (age-matched controls) prior to receiving the single 6-h exposure to 1500 ppm tl6C)MC. The routes of excretion and tissue concn. of 16C activity were similar between the singly and repeatedly exposed rats and mice. The major route of elimination of MC was exhalation of the pai-ent chem. in the expired air and constituted .apprx.97k of the total recovered radioactivity in rats and 92-96k in mice. The remaining radioactivity (.apprx.3-9/ ) was recovered as metabolised MC in the expired air (16C02 ) and nonvolatile radioactivity in the urine, feces, carcass, and cage wash. Mice eliminated MC more rapidly via the pulmonary route and biotransformed .apprx.5-fold more MC on a body ut. basis than rats. Repeated exposure to MC did not slgnificantly affect the disposition of MC compared to the singly exposed rats and mice. Thus, even after long-term repeated exposure to MC, its biotransformation remains limited. Comparison to previous results indicates that alterations in the pharmacokinetics of I160MC (increased body burden and decreased rate of pulmonary elimination) occur with age but not prior repeated exposure to MC. CAS REGISTRY NUMBER 71 t-55-6 ENTRY MONTH 8209 78 SECONDARY SOURCE ID AUTHOR AUTHOR AUTHOR ADDRESS Tit, c SL 030428 HEEP/82/11896 SCHUMANN AM FOX TR WATAHAE)E PG Toxicol. Res. Lab., HealTh and Environ. Sci . , 1803 Build., Dow Chemical U.S.A., Midland, Mich. 68660. Carbon-16-labeled methyl chloroform 00013805 1,1,1-TRICHLOROETHANE PAGE 55 SOURCE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH (1,1>1-trichloroethane ): Pharmacokinetics in rats and mice following inhalation exposure. TOXICOL APPL PHARMACOL; 62 (3). 1082. 390-401. TXAPA HEEP COPYRIGHT: BIOL ABS. Studies on the pharmacokinetics of C140CH3CC13 in male F i sch='' 344 rats and B6C3F1 mice were undo ken to characterize the disposition of the Inhaled chemical over a wide range of exposure concentrations. The animals were exposed to 150 or 1500 ppm of (14C)methyl chloroform vapor for 6 h and the elimination of 14C activity was followed for 72 h. Following exposure to either concentration of CH3CC13, both species excreted > 96% of the total recovered radioactivity during the first 24 h. The major route of elimination of CH3CC13 was via exhalation of unchanged chemical in the expired air which constituteds and 87-97% in mice at 150 and 1500 ppm, respectively. Mice eliminated CH3CC13 in the expired air more rapidly than did rats. The remaining radioactivity t 2-13%) was detected as metabolized CH3CC13 in the expired air (14C02) and as nonvolatile radioactivity in the urine, feces, carcass and cage wash. Although mice metabolized 2-3 times more CH3CC13 on a body weight basis, the biotransformation of CH3CC13 was a saturable, dose-dependent process in both species. Since the biotransformation of CH3CC13 occurred to such a limited extent, saturation of its metabolism did not impact markedly on the distribution or elimination of the parent chemical. The body burden, end-exposure blood level and tissue concentration of CH3CC13 overall increased in direct proportion with the exposure concentration. (14C)CH3CC13 was more concentrated in the fat of both species than in the liver or kidneys immediately after exposure. It was rapidly cleared from the fat so that by 24 h < 2% of the initial radioactivity remained. CH3CC13 shows little potential for significant bioaccumulation in rodent s. 71-55-6 8210 030^29 SL 00013806 1,1,1-TRICHLOROETHANE PAGE 56 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICA!ION TYPE COUNTRY ZIP CODE LANGUAGE CODEN 1NTL STAND SER NO ABSTRACT CA/096/1755698 CA/10900 3 Schumann AM Fox TR Watanabe PG Toxicol. Res. Lab., Health Environ. Sci., Dow Chem. USAi Midland [190Methyl chloroform (1,1,1-trichloroethane): pharmacokinetics in rats and mice following inhalation exposure Toxicol. Appl. Pharmacol.; VOL 62, ISS 3, 1982,390-901 JOURNAL ARTICLE USA 90690 ENG TXAPA 0091-008X CBAC COPYRIGHT: CHEM ABS Studies on the pharmacokinetics of 19C-labeled me thyl chloroform (I) [71-55-61 in male Fischer 399 rats and B6C3FI mice were undertaken to characterize the disposition of the inhaled I over a wide range of exposure concns. The animals were exposed to 150 or 1500 ppm for 6 h and the elimination of 19C activity was followed for 72 h. Following exposure to either concn. of I, both species excreted >967. of the total recovered radioactivity during the 1st 29 h. The major route of elimination of I was via exhalation of unchanged chem. in the expired air which constituted .apprx.99-987 of the total recovered radioactivity in rats and 87-977. in mice at 150 and 1500 ppm, resp. Mice eliminated I in the expired air more rapidly than did rats. The remaining radioactivity (.apprx.2-137) was detected as metabolized I in the expired air (19C02) and as nonvolatile radioactivity in the urine, feces, carcass, and cage wash. Although mice metabolized 2-3 times more I on a body wt. basis, the biotransformation of I was a saturable, doser-dependent process in both species. Since the biotransformation of I occurred to such a limited extent, satn. of its me tab. did not impact markedly on the distribution or elimination of I. The bodv burden, end-exposure blood level, and tissue concn. of I increased in direct proportion with the exposure concn. [190 1 was more coned, in the fat of both species than m the liver or 00013907 1,1,1-TRICHLOROETHANE PAGE 57 CAS REGISTRY NUMBER ENTRY MONTH 60 SECONDARY SOURCE ID AUTHOR AUTHOR ADDRESS TITLE SOURCE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 81 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR AUTHOR ADDRESS SL 030*31 kidnevs immediately after exposure. However, I was rapidly cleared from the fat so that by 24 h <2'/. of the initial radioactivity remained. Thus> I shows little potential for stcfnificant bioaccumulation in rodents. 71-55-6 6206 HEEP/83/09274 SCUDAMORE KA GOODSHIP G Ministry Agric.i Fish. Food, Slough Lab., Agric. Sci. Serv., London Rd., Slough, Berkshire SL3 7HJ. Effects of the moisture content-on The sorption and desorption behavior of fumigants on grain with special reference to 1,1,1-trichloroethane. PESTIC SCI! 13 (2). 1982. 149-155. PSSCB HEEP COPYRIGHT: BIOL ABS. A method was described for carrying out experimental studies on the interaction of fumigant vapors with food commodities under conditions of controlled moisture content. The amount of 1,1,1-trichloroethane (insecticide) adsorbed by wheat and maize during fumigation increased with the moisture content of the grain, but during subsequent airing, it was lost more rapidly from grain of higher moisture content. Except with the driest qrain used, the rate of loss of fumigant was usually more rapid at 25' C than at 10` C. When samples of wheat and maize were dried slowly during airing, the rate of loss of 1,1,1-trichloroethane was considerably reduced, almost none being lost in an initial 2 wk of re-equi1ibration. Some parameters affecting the sorption and loss of fumigants by food commodities were discussed, together with constraints in the interpretation of experimental data. 71-55-6 6308 CA/0 98/10 2 21IK CA/104003 Seppalainen AM Salmi T Sa'jolainen K Riihimaki V Inst. Occup. Health, Helsinki Ifni v. Cent. Hosp. , ^ ^ ^ || ^ 00013608 1,1,1-TRICHLOROETHANE PAGE 58 TITLE Visual evoked potentials in short-term exposure of human subjects to m-xylene and 11111-trichloroethane SOURCE Appl. Behav. Pharmacol. Toxicol., CLect. Workshop]; 1983,399-52 FUDl 'CATION TYPE MONOGRAPH COUNTRY Finland ZIP CODE SF-00290/29 LANGUAGE ENG CODEN 49DWA ABSTRACT CBAC COPYRIGHT: CHEM ABS In healthy male volunteers exposure to 1,1,1-trichloroethane 171-55-6] alone and in combination with m-xylene [108-38-3] induced changes in the brain visual evoked potentials, namely the latency of the start of the cortical response i-J was decreased. The brain of exposed subjects seemed to start reacting quicker but the processing thereafter might have been slightly impaired. CAS REGISTRY NUMBER 71-55-6; 108-38-3 .ENTRY MONTH 8309 82 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY LANGUAGE COD EH ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH CA/103/056312Q CA/159000 Sokal JA Kowalski Z Inst. Med. Pracy, Lodz Biological action of 1,1,1-trichloroethane with justification of the maximum permissible concentration of the compound in air at workplaces Stud. Mater. Monogr. - Inst. Med. Pr. LodziI ISS 1, Dzlalame Biol. 1,1,1-Troj chloroetanu , Dwuizocyjanianu Toluenu, Karbonylku Niklu Karbonyiku Zelaza, 1983,19-38 JOURNAL ARTICLE Pol. POL SMMLE CBAC COPYRIGHT: CHEM ABS Review chloroethane toxicity std air workplace;Air pollution Bv trichloroethane>, in workplaces, s tds. for;Standards For 1,1,1-trichloroethane in air of workplaces Legal and permissive 71-55-6 8509 030^32 SL I 00013609 1,1,1-TRICHLORDETHANE PAGE 59 83 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR TITLE SOURCE PUBLICATION TYPE COUNTRY LANGUAGE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH 89 SECONDARY SOURCE ID CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR ADDRESS TITLE SOURCE PUBLICATION TYPE COUNTRY ZIP CODE LANGUAGE CODEN 1NTL STAND SER NO ABSTRACT SL 030433 CA/103/092298Z CA/159005 Starsynski Z Editor Biological Activity of 1>11-Trichloroethane* Toluene Diisocyanate, Nickel Carbonyl, and Iron Carbonyl with Jostification of the Maxi mum Permissible Concentration of the Compounds in Air at Workplaces 1983)119 pp. MONOGRAPH Pol. POL BOOKA CBAC COPYRIGHT: CHEM ABS Book std workplace air Trichlorethane std workplace book Toluene diisocyanate std workplace book Nickel carbonyl std workplace book Iron carbonyl std workplace book;Air pollution By trichioroethane and TDI and metal carbonylst in workplaces) stds. for;Standards For workplace air concns. of trichloroethane and TDI and metal carbonyls Legal and permissive 71-55-6! 13963-39-3; 15281-98-8; 26971-62-5 8510 CA/102/16176ON CA/109003 Takano T Miyaraki Y Motohashi Y Sch. Med.> Tokyo Med. Dent. Univ.( Tokyo Interaction of trichloroethane isomers with cytochrome P 950 in the perfused rat liver Fundam. Appl. Toxicol.; VOL 5> ISS 2> 1985,353-60 JOURNAL ARTICLE Japan 113 ENG FAATD 0272-0590 CBAC COPYRIGHT: CHEM ABS The real-time interactions of 1(1>1-trichloroethane (TCE) [71-55-6] and 1,1,2-TCE [79-00-5] with cytochrome P 950 [9035-51-2) were obsd. using in vivo optical methods to measure the spectral changes of cytochrome P 950 and the redn.-oxidn. transition of pyridine nucleotides in the perfused liver of rats treated with phenobarbital. Changes in 0 consumption and TCE uptake were also 00013810 1,1,1-TRICHLDRDETHANE PAGE 60 measured. The spectral changes of cytochrome P 450 indicated that both TOE isomers bound to lcu-spin (substrate-free ) ferric cytochrome P 450 and formed a hiqh-spin (substrate-complexed ) form. However , 1.1.1-TCE bound more tightly to cytochrome P 450 and seemed to be only slowly metabolized compared to 1,1,2-TCE. The stolchiometry of the chanqe in 0 consumption rate to the change in 1,1,1-TCE uptake rate ranged between 5/1 and 9/1, whereas that of 1.1.2-TCE was 1.4 to 2.0. Decreases in ' J reduced pyridine nucleotides assocd. with TCE administration were significantly larger with 1.1.1-TCE than with 1,172-TCE. The inhibitory effect of 1,1,1-TCE on ` if he.xobarbt tal 156-29-1] metab. in the perfused liver was greater than that of 1.1.1-TCE. Considering previous data indicating that TCE did not stimulate mitochondrial respiration, it is postulated that the far higher amt. of 0 consumption assocd. with the binding of 1,1,1-TCE to cytochrome P 450 than the amt. which was necessary to mlxed-function oxidn. of this compd. was due to an uncoupling effect of 1.1.1-TCE on the mixed-function oxidase [4040-60-2] system. CAS REGISTRY NUMBER 56-29-1; 71-55-6; 79-00-5! 110-86-1! 9035-51-2! 9040-60-2 ENTRY MONTH 8506 85 SECONDARY SOURCE ID AUTHOR AUTHOR ADDRESS TITLE SOURCE CODEN ABSTRACT SL 030434 HEEP/83/07300 WESTERESERG E LARSSON L Lab . Exp . Brain Res., E-blocket, Univ. Hosp., Lund, Sweden. Use of automated headspace gas chromatography for determination of 1,1,1-trichloroethane in rat blood and brain tissue. INT J ENVIRON ANAL CHEM; 12 (3-4). 1982. 233-240. IJEAA KEEP COPYRIGHT: BIOL ABS. 1.1.1-Trichloroethane in blood and brain tissue from rats artificially ventilated with solvent (8000 ppm) was analyzed by automated headspace qas chromatography using a fused silica capillary column. A given concentration of 1,1,1-trlchloroethane in the brain could be correlated with a --rrespondlnq concentration in the blood; the uptake and release of the solvent were s 00013811 1,1,1-TRICHLOROETHANE PAGE 61 CAS REGISTRY HUMBER ENTRY MONTH 86 SECONDARY SOURCE ID AUTHOR ADDRESS TITLE SOURCE LANGUAGE CODEN ABSTRACT KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS CAS REGISTRY NUMBER ENTRY MONTH 87 SECONDARY SOURCE 10 CLASSIFICATION CODE AUTHOR AUTHOR AUTHOR TITLE SOURCE PUBLICATION TYPE LANGUAGE ABSTRACT quicker in blood than in brain. No volatile metabolites of the solvent were found. Automated headspace gas chromatographic analysis was a rapid and sensitive technique for the quantitative registration of volatile organic solvents, e.g., of industrial importance , in body fluids and tissues. 71-55-6 8306 IPA/84/02244 Wi diner HR Inselspital-Apothekei 3012 Berne. Switzerland Substitute of medical benzene by 1,1,1-trichloroethane (Aerothene TT) Schweiz. Apoth. Ztg. ; VOL 120 ISS 11 1982, P247 GER SAZTA IPA COPYRIGHT: ASHP The use of 1,1,1-trichloroethane (Aerothene TT; tri chloroethane ! me thy lchlorof orin t, a fireproof and less toxic substitute for medical benzene, was reported. TRICHLOROETHANE BENZENE SOLVENTS SUBSTITUTION, BENZENE TOXICITY, SUBSTITUTION, TRICHLOROETHANE TOXICITY, ENVIRONMENTAL TOXICITY, SUBSTITUTION, BENZENE SUBSTITUTION, TRICHLOROETHANE 71-55-6; 71-43-2! 8401 CIS/84/00750 130 Wise MG Fisher JG de la Pena AM Trichloroethane (TCE) and central sleep apnea: A case study Journal of Toxicology and Environmental Health Jan. 1983, Vol.ll, No.l, p.101-104. 9 ref. JOURNAL ARTICLE Eng The case is reported of severe central sleep apnoea in a man heavily exposed to TCE, working in a typewriter repair shop. Clinical findings during hospitalisation are presented. Symptoms disappeared with the use of respiratory assistance. The possibility of ooo i3pr- # 1*1,1-TRICHLOROETHANE PAGE 62 KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS KEYWORDS ' ) CAS REGISTRY NUMBER ENTRY MONTH 63 SECONDARY SOURCE ID AUTHOR AUTHOR ADDRESS TITLE SOURCE LANGUAGE CODEN ABSTRACT 5^ U3fe a causal relationship with TCE is discussed. TRICHLOROETHANE ORGANIC SOLVENTS RESPIRATORY IMPAIRMENT ARNOEA CASE STUDY SLEEP ILO 71-55-6 8911 CA/095/092129F Woolverton WL Balster RL Med. Coll.) Virginia Cominonu. Univ.t Richmond Behavioral and lethal effects of combinations of oral ethanol and inhaled 111.1- trichloroethane in mice Toxicol. Appl. Pharmacol.! VOL 59* ISS 1, 1981.1- 7 ENG TXAPA CBAC COPYRIGHT: CHEM ABS Acute behavioral and lethal effects of oral EtOH and inhaled 1.1.1- trichloroethane (TCE) alone and in combination were detd. In mice. (69-17-5 EthanolM 71-55-6 1,1,1-Tr1chloroethane ) Behavioral effects were measured by a test that required mice to climb to the top of an inserted screen. When combinations were tested, doses of EtOH were administered 30 min before a 30-mln exposure to various concns. of TCE. Interactions were quantified using iscboloqrams . The percentage of mice affected for both behavioral and lethal effects was dose related for each compd., alone and in combination. For lethality, EtOH shifted the TCE concn.-effect curve to the left in a parallel manner, with the magnitude of the shift directly related to the dose of EtOH. Combinations of low doses of EtOH with TCE were usually supraadditive , whil.e higher doses of EtOH were additive or infrnadditive with TCE. Shifts to the left of the TCE concn.-effect curves for behavioral testinq similarly depended on dose of EtOH, but were nonparallel. Effects of low concns. of TCE were shifted farther to the left (supraaddit)ve ) than were the effects of high concns. of TCE (additive or 1nfraadd111ve ). Probably, in many combinations, significant acuta toxicity may occur with joint administration of EtOH and * * * ) 00013013 1,1,1-TRICHLOROETHANE PAGE 63 CAS REGISTRY NUMBER ENTRY MONTH 09 SECONDARY SOURCE 10 AUTHOR AUTHOR TITLE SOURCE LANGUAGE CODEN ABSTRACT CAS REGISTRY NUMBER ENTRY MONTH TCE. Health hazards to workers who ingest ETON prior to on-the-job exposure to TCE are ditrussed. 6'- t -5; 71-55-6 8110 HE EP/85/07705 WRIGHT MF STRODE 0J 111 TRICHLOROETHANE CARDIAC TOXICITY REPORT OF A CASE J AM OSTEOPATH ASSOC; 89 (3). 1989. 85-288. ENG ---------------------------------------------------- JAOAA HEEP COPYRIGHT: BIOL ABS. RRM VENTRICULAR ARRHYTHMIA OCCUPATIONAL EXPOSURE 71-55-6 8506 ^ # * * END OF OFFLINE PRINT K H # It K q3 9V