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tDCTD PPO - 84- e ALLEGATION OF SIGNIFICANT ADVERSE E ACTION TOXIC SUBSTANCES COVTHX ACT (TSCA) SECTION 8 ( C ) (Name of ailecer lYear of Birth IDate of receipt of allegation at site 1 1-S* 1 is-PI -- 'I 8-/SW IJoto title or description 1Sex * 1Location of plant receivina allecation lJ _ , 11 (Vm-) OC (F) 1 -, 1 t Cl L ;!/ (Signature (Date of Occurence 1Street address, city, state, zip , /? f- r / r v 1/S ^ r / # } ftC /S Z tS -e t i-V ? i / , t .2 . Type o f alle g e d s i g n i f i c a n t ad v e rse re a c tio n : r_ id * I Horan H ealth E f f e c t Environm ental E ffe c t 3. D escribe the probable cau se o r s itu a tio n a sso c ia te d w ith th e a lie n e d s ig n ific a n t adverse reactio n (see " In s tru c tio n s 1*J. t o n e w uun.___ T * ri-________ F ___ ftagv,__ a -j to P a s s *<> A>___tVftAHf ^ -> T M ----u J - g g i O ___________________________________________ 4. S irnrarize th e a lle g e d s i g n i f i c a n t ad v erse r e a c tio n ( s ) . Foe a lle g a tio n s o f biman e f f e c ts , d e s c rib e th e n a tu r e and e x te n t o f th e e f f e c t s , in c lu d in g hew th e e f f e c ts became knevn and ro u te o f presum ed exposure ( i f known). F or a lle g a tio n s o f environm ental e f f e c ts , d e s c rib e the alleg ed environm ental e f f e c ts , id e n tify the affected p la n t and/or anim al sp ec ie s or contam inated p o rtio n o f the physical environm ent. fra a -w e s-----1&__ d rrr* > i* .,u f^ A8but T > ,r r .< w tr w 1 g a in or.__ n i j . r t- jiu - r s ___ Ct;<uc\gt n m. A. vira THtv^ UAQ* t y j o d v / r \ ___A t t w --- R.t,fimi--- Bc2--- ft--- E L x i ViCfttgl___A a. r K;/=gA r.V iPU ioft.__ Irw Tttfr 'enft- S. R e s u lts o f any s e l f - i n i t i a t e d i n v e s t i g a t i o n w ith r e s p e c t t o an a l l e g a t i o n f i l e d S nor, _C_D under Section 8 (c ). A ttach co p ies o f other re q u ired reco rd s or re p o rts re la tin g to ^ j a l l e g a t i o n u n d e r S e c t i o n 8 ( c ) , e . g . , CSKA form 1 0 1 . . Required only fo r h e a lth e f f e c ts . (OVER) c- L 0 0 1 1 0 B EID5230Q9 \ REDACTED ( (Person subm itting lallecation info. I IS icm atuce l A llegation feviewed by: IJob T itle 1Telephone Number E x te n sio n 1 1C ) - 1 __________ I________ 1S t r e e t a d d re s s , c i t y , s t a t e , z ip t&r/t'&rsSc/PS /o z. Name V. L .'P o w e r , H . i . v j -Qr. koscV w xvo I T itle 1 | | Location 1 V/&.rkin^Dn W o rk s * ` ^ ` '* 1 W orks I Date 1 y -i3 -a * / 8 - 1 3 - 8 1# m w1 1 L tlyrf lO 1 1 1O 1 8. D isposition o f S ection 8(e) sig n ific a n t adverse reactio n a lle g a tio n : / I ! ifecorded: 7 Not recorded !^ li?/sc 1 1 In fo rm atio n i s a k n w n human e f f e c t a s described in s c ie n tific lite r a tu r e , product lab elin g or in m aterial safety data sheets A llegation does not meet d efin itio n o f sig n ific a n t adverse re actio n Inform ation has been subm itted under other mandatory re p o rtin g requirem ents to th e fed eral government and m eet requirem ents of S e c tio n 8 ( c ) o f TSCA i-- r O ther j*SX001109 EID523010 I TALKING POINTS 8;C) ALLEGATION (COVER CRALLT ITH EMPLOYEE) We have reviewed your recent allegation. It is being recorded according to TSCA 8(C) guidelines. Under the conditions of use in the Teflon area, the chemicals present are not known to cause male infertility. Since we always have an interest in the ongoing well being of peoole, we welcome your comments to further our understanding of the facts in your expressed concern. These would be of value in any future con siderations we may undertake. Give employee a copy of his allegation which indicates that it has been reviewed by those listed on page 2 and recorded by the PPO coordinator. HE3/clt. 0/18/84 S L O O lllO E'CiL' C' ' .j-fc?irv E. f. o u Po n t oe N e m o u r s & C o m p a n y W il m in g t o n . Dela w a r e 19898 POV.YMC MOOUCTJ OCPTMINT CC: B. W. CULPEPPER, ER J. T. SMITH C. F. RIDDICK 6. A. HAPKA, LEGAL M. h. CHRISTMAN, LEGAL L. F. PERCIVAL H. E. SERENBETZ/J. W. RAINES H. V. BRADLEY, WASH. WKS. December 18, 1984 f 'IV? r TO: PPD 8(c) FILE (R. E. STAHL) FROM: . R. D..INGALL5 RECTD ..w .ISCA c ) Al6M.l.QIL^;S,v^ WASHINGTON WORKS .' .v:. PPD 84-1-E V ,. _. , 'i-tf* -M L ' Allegation .-- .* . .... .* _ An employee assigned to the "Teflon" area alleged'that several male T.T'~~ operators had coeplalned that their marriages had become'less fertile after they had worked in the "Teflon" area for a few .years;. ---lit Disposition e The allegation was recorded and the.employee was so advised. a He was asked for any further elaboration he cared to share. He claimed a half dozen people had complained, but he named only two (memo to file by T. L. Schrenk). Follow-up Action The plant support team was polled ami wen^-not cognizant of any concern about infertility in the "Teflon" airea or elsewhere . on the plant. e The plant physician had not heard complaints similar to that alleged. t Haskell Laboratory made a quick literature searcn and did not find-Scientific evidence U n k i n g a 11st of "Teflon" area chemicals to effects on the male reproductive;system (letter by R. R. Montgomery, ` Haskell also reviewed information-on the major-area chemicals including hexafluoroacetohi^fonaerly used. With input from L. F. Percival, who had know)edge;of conditions of use of the chemicals at Washington Works, it was concluded t h a t . under the conditions of use,.these chnicals. should not' impair male reproductive function (litter from W. L. Sprout, 10/23/84). - V" Batter Things For Batter Living... from Ou Pont S L O O llll EID522012 u. Because of the absence of evidence of significant employee concern, and the negative findings from Haskell's review, further followup (including contact with the two named employees) at this time was not judged to be warranted. SL001112 EID523C1 Klon tv MD cc: J- B. Arnitage, PPD, CHS-314 L. F. Percival, Kasxell E. I. ou P o s " oe N e m o u r s & C o m p a n y MA5-:LL * 7 9 TOX:CO_OGT a\ 3 'S3-5"=>'AWM t'C S S O B : t 50. E_<~ON S a : n s w a p k . D ela w a re '9 7 1 ! CEN-PAL. RESEARCH AND DEVELOPMENT DEPARTMENT O ctober 18, 1934 R. D. INGALLS PPD M-5625 CHEMICALLY INDUCED REPRODUCTIVE EFFECTS IN xMALES Under separate cover L. F. Percival has sent you MEDLINE, TOXLINE, and CHEMLINE (plus pertinent backfile) printouts generated in connection with your recent inquiry on male reproductive effects associated with a series of chenicals that were identified by J. G. Loschiavo. The list of-this series of chemicals plus the checksheets on Haskell correspondence files prepared by V. Berryhill were also enclosed in L. F. Percivai's package. This letter will confirm that in a very quick scan of the MEDLINE citations* I did not observe any direct connection to the chemicals on J. G. Loschiavo's list. No attempt was made to check details or original sources. Please do not hesitate to call if you should have any question when examining these printouts or other related data. :U*- R. R. MONTGOMERY INFORMATION ANALYST RRM:ldp * See attached sheet for details of strategy. SL001113 CI2 - DISIaSES-UROLOGIC and MALE GENITAL 10L0G1C AND MALE GENITAL DISEASES (NON MESH) 'TT YOLOGIC AND MALE GENITAL DISEASES (NON ESH) GENITAL DISEASES, MALE 02 02-294 EPIDIDYMITIS 02-294.199 GENITAL NEOPLASMS, MALE C12-294.269 HEMATOCELE 02.294.287 HERPES GENTTAUS HYDROCELE INFERTILITY INFERTILITY, MALE C12.294J00 02-294-349 02-294-36$ C12J94J65.700 OLIGOSPERMIA CUJ94J65.700J08 PENILE DISEASES CIL294.494 BALANITIS KRAUROSIS PENIS PENILE INDURATION 02.294.494.136 C l2.294.494.136JHH 02-294.494.508 PENILE NEOPLASMS C12J94.494.591 PHIMOSIS C12J94.494.684 PARAPHIMOSIS CUJ94.494.684.387 PRIAPISM CUJ94.494.786 PROSTATIC DISEASES 02J94.563 PROSTATIC HYPERTROPHY 02-294.565JOO PROSTATIC NEOPLASMS CU.294J6S.62S PROSTATITIS SEX DISORDERS IMPOTENCE CUJ94J63.7S0 C12J94.644 02J94.644.466 SPERMATIC CORD TORSION 02J94.693 SPERMATOCELE C12J94.731 TESTICULAR DISEASES 02.294.829 ORCHITIS C12J94.829.493 TESTICULAR NEOPLASMS C12.294.829.782 TUBERCULOSIS, MALE GENITAL C12J94J89 VARICOCELE TUBERCULOSIS. UROGENITAL C12J94S36 02.672 TUBERCULOSIS, MALE GENITAL CU.672.72l TUBERCULOSIS. RENAL 02.672.847 UROLOGIC DISEASES 02.777 BLADDER DISEASES 02.777.103 BLADDER CALCULI CU.777.103.U6 BLADDER FISTULA CU.777.103J87 VESICOVAGINAL FISTULA C12.777.103.187.733 BLADDER NECK OBSTRUCTION CU.777.103J49 BLADDER NEOPLASMS 02.777.103.312 BLADDER NEUROGENIC C12.T77.103J74 CYSTITIS 02.777.103.695 VESICOURETERAL REFLUX 02.777.103.920 HEMATURIA 02.777.295 HEMOGLOBINURIA 02.777.337 KIDNEY DISEASES 02.777.419 ANURIA 02.777.419.78 OLIGURIA 02.777.419.78.374 DIABETIC NEPHROPATHIES 02.777.419.192 FANCONI SYNDROME 02.777.419.250 HYDRONEPHROSIS 02.777,419.307 HYPERTENSION, RENAL C12.777.419.331 HYPERTENSION, RENOVASCULAR 02.777.419.331.490 KIDNEY CALCULI 02.777.419.373 KIDNEY CORTEX NECROSIS 02.777.419.393 KIDNEY. CYSTIC 02.777,419.413 KIDNEY, POLYCYSTIC 02.777419.413.420 KIDNEY, SPONGE 02.777.419.413.586 KIDNEY FAILURE. ACUTE CU.777.419.433 KIDNEY TUBULAR NECROSIS. ACUTE 02.777.419.433.503 KIDNEY FAILURE. CHRONIC 02.777.419.453 !'iO'C\TF5 VINO* DESCRIPTOR 97 -- ----- - -- .- CUtlJM f. C 33J40M CLU4.444. <a u n j C lJJTU tt _ mJMTU O IJM M , C ttJtiM I VU9MM n.igRj*>. C4WBI C1JSL4AL c u jrjn CU9ZM> CUS2.4L CLffiA CIJHM cora.ni corm a c o sa CU.TT7AU. cirm j C 12.7T7 COJTUM. CU.Tn.7fT. a u v u n CBJMjn. murm a ijrt.li. ciMJurr. Cll.iM.4Sl CS.UA.IM. C I M .n 4 C ll a4.MT.4M, C IO fff.4 . cam#. C4.1MJM C4.1B2JM. C4.IA2JM. C itili JM. SL001114 E'DS23C' i  c n n *rv i c E . 1. du P o n t d e N e m o u r s S C o m p a n y -teeewtf H a s K E ! __ ' C * " C X IC O L O G V s v j r < : u 5 " i a . M - 3 :c i n P O Box 50 Ei.k-'onj Ro a d NE WARK. 3 ELA. VAR s 1 9 7 1 1 central rcsearch and development department October 23, 1984 cc : B. W. K a r r h - ER G. W. L o v e t t L. F. P e r c i v a l E. D. Riehl N -1 1543 R. 0. INGALLS POLYMER PRODUCTS DEPARTMENT M-5625 REPRODUCTIVE EFFECTS: TEFLON* CHEMICALS 1 have reviewed toxicological inforieation, including summaries of reproductive effects, on fluorocarbon 22, tetrafluoroethylene, hexafluoropropylene, and other compounds used in the manufacture of Teflon*. I c o n c l u d e that under the c o n d i t i o n s of use in Ou Pont's manufacturing sites, none of these materials presents a hazard of impairment to reproductive function in either sex. W I L L I A M L. SPR O U T , M.D. MEDICAL CONSULTANT WLS/egg SL001115 EiDS:3:'i FACSIMILE TRANSMISSION COVER SHEET DATE: TO: NAME _ _ _ _ _ _ _ _ _ _ DEPT. P P P _ _ _ _ _ _ _ _ _ _ _ ' LKATION /n S 6 2-S_________ FROM: NAME ~7% *1 DEPT. P P P ________________ LXATION U'sts A y -fr~ ___ TOTAL PAGES . (including cover sheet) PLEASE COPY _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ 22S7A:001SA 11:4.3 NO. 3 0 6 001 S L001116 EID5230 : 77. / L : J~, Scsi* /*JkT*+ - S'*fHt/ t *'+*,/ /$ /* * & * . 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