Document JrY8ME8EV0wveV2w2xKYv4Xe2

NOTICE Enclosed you will find a summary listing of tumor rates in the NTP historical control data base as of late March, 1983. All tumors occurring with a frequency of 0.5% or greater are included. This summary will also be published in a future issue of the NTP Technical Bulletin (as may periodic updates). A revised summary listing will be generated approximately every 6-9 months. I hope that this information will be useful to you. l+CM-eVKtf.vi SU B JEC T TO PROTECTIVE ORDER. 0037? ---- --* xiiLiuences Jin untreated control r 344 rats and B6C3F j ce1 NIP historical control data base as of March 1983. Included are ali tumors with a spontaneous frequency of le . The data base consists of those NTP studies with Technical Report number 193 or greater. TABLE 6 . INCIDENCES OF PRIMARY TUMORS IN UNTREATED CONTROL F344 RATS AND B6C3F2 MICE8 MALE RATS Number of SO Range Tumors (5) (S) (%) FEMALE RATS Number of SD Range Tumors(S) () U ) tegumentary System 2320b '.euro)F ibroma 107(4.6) '.euro )Fibr osar coma 27(1.2) ireoma, NOS 10(0.4) quamous Cell Papilloma 29(1.2) uamous Cell Carcinoma 20(0.9) isal Cell Neoplasms 22(0.9) jratoacanthoma 20(0.9) .poma 12(0.5) 3.2 0-12 1.4 0-4 1.0 0-4 1.7 0-5 1.3 0-4 1.6 0-6 1.4 0-4 0.9 0-4 2370b 34(1.4) 1.5 2 0 (0 .8 ) 1.3 7(0.3) 0.7 6(0.3) 0.7 15(0.6) 1.2 6(0.3) 0.7 6(0.3) 0 .8 1 0 .1 ) 0.3 0-4 0-4 0-2 0-2 0-4 0-2 0-4 0-2 MALE MICE Number of SD Range Tumors(5) (S) (5) 2343b 28(1.2) 2.7 6 6 (2 .8 ) 4.4 40(1.7) 2.5 3(0.1) . 0.5 4(0.2) 0.7 2 (0 .1 ) 0.4 0 (0 .0 ) 0.0 0 (0 .0 ) 0.0 0-12 0-19 0-12 0-2 0-4 0-2 FEMALE MICE Number of SD Range ; Tumors(5) (5) (5) 2486b 1 0.1 ) 0.6 0-4 2 1 (0 .8 ) 1.9 0-8 17(0.7) 1.6 0-10 6 (0 .2 ) 0.7 0-2 6 (0 .2 ) 0.7 0-2 5(0.2) 0.8 0-2 0 (0 .0 ) 0.0 0 (0 .0 ) 0.0 piratory System mg Alveolar/Bronchiolar Adenoma Alveolar/Bronchiolar Carcinoma 2305 35(1.5) 20(0.9) 2.1 0-6 1.6 0-6 2354 18(0.8) 1.4 0-6 9(0.4) 0.9 0-4 2328 282(12.1) 6.7 0-28 119(5.1) 4.3 0-18 2388 131(5.5) 3.6 0-14 47(2.0) 2.3 0-8 estive System ver 2306 Neoplastic Nodule or Adenoma 78(3.4) Ca'"-" 'oma 18(0.8) No or Adenoma or Carcinoma 96(4.2) restomach 2276 Squamous Cell Papilloma 5(0.2) Squamous Cell Carcinoma 1(<0.1 ) i l l Intestine 2212 Adenocarcinoma 9(0.4) 3.5 0-12 1.1 0-4 3.9 0-14 0.6 0-2 0.3 0-2 0.9 0-4 :crine System -.uitary, Pars .stalis .denoma 'arcinoma enal orticai Adenoma orticai Carcinoma neochromocyt oma neochromocytoma, malignant :oid -cell Adenoma -cell Carcinoma illicular cell .denoma arr:-- 13 rei Islets enoma ircinoma 2158 468(21.7) 11.7 51(2.4) 3.0 2280 27(1.2) 1.3 5(0.2) 0.6 388(17.0) 9.2 2-52 0-11 0-4 0-2 6-41 23(1.0) 2230 114(5.1) 84(3.8) 1.4 0-6 4.4 0-18 3.3 0-12 22(1 .0 ) 17(0.8) 2226 84(3.8) 46(2.1) 1.4 0-5 1.4 0-7 3.6 0-12 2.3 0-9 2356 71(3.0) 3.0 4(0.2) 0.7 74(3.1) 3.2 2329 5(0.2) 0.8 2 (0 .1 ) 0.4 2284 1 0 .1 ) 0.3 2262 995(44.0)11.4 80(3.5) 4.7 2338 74(3.2) 4.0 7(0.3) 0.7 81(3.5) 3.0 11(0.5) 2265 111 (4.9) 81(3.6) 1.0 4.1 3.0 10(0.4) 10(0.4) 2303 18(0.8) 6(0.3) 1.0 0.9 1.5 0.8 0-12 0-4 2334 240(10.3) 498(21.3) - 5.5 6.9 0-24 8-36 2469 98(4.0) 3.9 o - i e 101(4.1) 3.0 0-15 0-12 0-4 0-2 0-2 18-70 0-19 0-24 0-2 0-16 725(31.1) 7.5 16-58 2252 6(0.3) 0.7 0-2 0 (0 .0 ) 0.0 2148 14(0.7) 1.2 0-4 `TKT' '1V r t E 196(7.9) 4.6 2336 12(0.5) 1.5 2 (0 .1 ) 0.4 2234 2 (0 .1 ) 0.4 ^ T7-N T\ T T-wi-lITT A ^ ts r f r IA 0-20 0-4 0-2 0-2 *_ I ' OJ S U B J E C T T O P R O T E I V E O R D E R. 1 1 (0 .6 ) 1.5 0-6 1 (0 .1 ) 0.3 0-2 2240 53(2.4) 3.0 0-15 3(0.1) 0.6 0-4 28(1.2) 1.9 0-6 163(7.9) 8.5 8(0.4) 0.9 2306 7(0.3) 1.1 1 0 .1 ) 0.3 16(0.7) 1.2 0-32 0-5 0-4 0-2 0-4 0-4 0-13 0-12 2 (0 .1 ) 2178 0(0.0) 0(0.0) 0.4 0.0 0.0 0-2 0(0.0) 0.0 2203 2 (0 .1 ) 0.4 0-2 0(0.0) 0.0 0-4 2 2 (1 .0 ) 1.6 0-6 0-2 5(0.2) 0.6 0-2 2237 0-7 8(0.4) 0.9 0-4 0-4 0(0.0) 0.0 40(1.8) 2.1 0-9 6(0.3) 1.5 0-10 220 9(0.4) 0.8 0-2 2 (0 .1 ) 0.4 0-2 WW uuwtKUL F344 RATS AND B6C3Fi MICE8 (con't)' MALE RATS Number of SO Range Tumors (!S) (5S) (5) FEHALt RATS Number of SO Range Tumors(S) (Si) (SS) MALE MICE Number of SO Range Tumors(SO () (5) / FEMALE MI Number of SO R Tumors(5) (X) 'vmary Gland fibroadenoma Adenocarcinoma 2320 51(2.2) 2.0 6(0.3) Q.7 eputial" Gland Adenoma Carcinoma 2320 50(2.2) 3.4 63(2.7) 3.0 ostate Adenoma 2154 14(0.6) 2.0 stis 2285 Interstitial Cell Tumor 2002(87.6) 8.9 itoral Gland Adenoma Carcinoma erus Endometrial Stromal Polyp Endometrial Stromal Sarcoma ary Granulosa Cell Neoplasms Tubular Adenoma 2370 0-8 572(24.1) 10.1 2-44 0-2 48(2.0) 2.4 0-8 0-16 0-10 0-10 59-98 2370 28(1.2) 1.8 0-6 46(1.9) 2.7 0-12 2318 424(18.3) 8.1 4-37 25(1.1) 1.7 0-6 2321 13(0.6) 1.0 0-4 0(0.0) 0.0 2343 0(0.0) 0.0 0(0.0) 0.0 2343 2(0.1) 0.4 0-2 0(0.0) 0.0 2343 0(0.0) 0.0 2312 8(0.3) 0.9 0-4 - atopoietic System Leukemia Lymphoma i.eukemia/Lymphomac 2320 648(27.9) 10.2 51(2.2) 3.4 699(30.1) 10.5 0-46 0-16 10-54 2370 414(17.5) 7.4 0-38 36(1.5) 2.2 0-10 448(18.9) 7.0 6-38 2343 17(0.7)' 1.7 280(12.0) 7.2 297(12.7) 7.3 0-10 2-32 2-32 2486 / 8(0.3) 1.1 0* 40(1.6) 2.3 0- 2486 0(0.0) 0(0.0) 2360 22(0.9) 13(0.6) 2167 2(0.1) 19(0.9) 0.0 0.0 1.4 0-6 1.2 0-4 0.4 0-2 1.4 0-7 2486 52(2.1) 4.6 625(25.1) 10.0 677(27.2) 9.9 0-28 8-62 8-62 ^ ^jtory System mangioma aangiosarcoma 2320 M0-2) 12(0.5) 0.6 1.1 0-2 0-4 2370 2(0.1) 3(0.1) 0.4 -2 0.5 0-2 2343 34(1.5) 3.3 0-16 64(2.7) 2.6 0-10 2486 39(1.6) 1.9 0-6 48(1.9) 2.3 0-8 vous System ain Astrocytoma 2301 9(0.4) 1.0 0-4 2348 12(0.5) 1.1 0-4 2303 0(0.0) 0.0 2378 0(0.0) 0.0 cial Sense Organs rderian Gland Adenoma Carcinoma 2320 1K0.1) 0.3 10.1) 0.3 0-2 0-2 2370 0(0.0) 0(0.0) 0.0 0.0 2343 50(2.1) 2.8 0-12 2(0.1) 0.4 0-2 2486 32(1.3) 1.7 0-6 10.1) 0.3 0-2 ruloskeletal System 2320 Leosarcoma 12(0.5) 1.0 Jbdomyosarcoma 0(0.0) 0.0 0-4 2370 7(0.3) 2(0.1) 0.8 0-4 0.4 0-2 2343 3(0.1) 0.7 0-2 12(0.5) 1.6 0-8 2466 14(0.6) 1.1 0-4 2(0.1) 0.4 0-2 er Tumors :othelioma (tunica iginalis) othelioma. (other) 2320 30(1.3) 23(1.0) 1.7 1.7 0-8 0-8 2370 1(<0.1) 0.3 0-2 2343 0(0.0) 0.0 3(0.1) 0.5 012 2486 * 0(0.0) 0.0 eludes a l l tumors o c c u r r in g w ith a frequency o f 0.5X or g r e a t e r . # iVi J & B S + L*sa lfc r& Vi Si H ft] >_ yr SU B JE C T TO PROTECTIVE ORDER `* ci1 j animals examined h is to p a th o lo g ic a lly (o r , for c e r ta in le s io n s , the number o f animals n e c ro p s ie d ). nation is included because certain early studies in the data base tended to use these terms interchangeably.