Document JrGw9OdKYR19E2eQoKe2anBnv

DownloadSearchable PDFRandom document
AUG 161976 MANUFACTURING CHEMISTS ASSOCIATION 182b CONNECTICUT AVENUE, N. W. WASHINGTON. D. C. 20009 (202) 483-6126 August 13, 1976 Vinyl Chloride Research Coordinators SUBJECT: Exposure Concentration Data For Long-Term Inhalation Study Gentlemen: The subject information is enclosed for your perusal along with cover letter of August 10 from Dr. Goode. Dr. Torkelson felt this topic should be discussed at the next meeting of this group which is still unscheduled. Sincerely MF:ec Enclosure Milton Freifeld ' Project Manager Vinyl Chloride Research EPL 01465 VINYL CHLORIDE RESEARCH COORDINATORS Dr. Z. G. Bell, Jr. PPG Industries, Inc. One Gateway Center Pittsburgh, Pennsylvania 412-434-2585 15222 Dr. W. D. Harris UNIROYAL, Inc. ,,EMIC Building Naugatuck, Connecticut 06770 203-573-2000, ext. 2139 Dr. M. N. Johnson The B. F. Goodrich Company Medical center 500 South Main Street Akron, Ohio 44318 216-379-3298 Mr. H. L. Kusnetz Shell Oil Company Box 2463 Houston, Texas 77001 713-220-5604 Dr. W. M. Smith Air Products and Chemicals, Inc. P. 0. Box 538 Allentown, Pennsylvania 18104 215-395-7215 Dr. T. R. Torkelson, Chairman ' The Dow Chemical Company Corporate Medical Department 2030 Dow Center Midland, Michigan 48640 517-636-5197 Mr. R. n. Wheeler Union Carbide Corporation Chemicals & Plastics Division P. O. Box 8004 South Charleston, West Virginia 304-747-2164 25303 0l466 3ru3uAtAwl BIO -TEST DECATUR RESEARCH 1800 EAST PERSHING ROAD TOXICOLOGY Environmental sciences . , Chemistry PLANT SCIENCES MEDICAL sciences DECATUR, I LLINOIS '62526 August 10, 1976 , 3rue. area code TELEPHONE 677 -925A Dr. Milton Freifeld Project Manager Manufacturing Chemists Association 1825 Connecticut Avenue, N. W. Washington, D.C. 20009 Dear Milt: Enclosed are ten copies of the means for the 261 exposure days of the vinyl chloride study. The averages of these means are: 50. 15 ppm for T-I Target 50 ppm 200. 10 ppm for T-II Target 200 ppm 2465. 71 ppm for T-III Target 2500 ppm 24 67. 23 ppm for T-IV Target 2500 ppm T-IV as you will recall, was the group allowed food and bedding during exposure. The concentration data are also available in the 7th and 18th month status reports on this project. If I can be of any further service to MCA, please do not hesitate to call me. Sincerely, C')ML l^nW. Goode, Ph.D. ( ' Manager, Decatur Research Laboratories .1 WG/dm one. EPL 01467 Uadu&biial B I 0 T E S T Jai&UMOAl&l, Unc. TABLE TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study In Albino Rats, Albino Mice, and Golden Hamsters Exposure Number 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 . 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 Mean Chamber Concentration Data TE-I Chamber Concentration (ppm) TE-II TE-III 43 173 48 181 50 207 51 87 52 218 57 194 53 199 56 164 58 242 62 186 60 202 60 156 58 207 59 162 47 160 49 211 60 219 51 201 50 214 62 ' 242 58 219 56 265 46 220 45 106 51 212 47 203 55 225 52 184 43 209 50 209 52 180 48 177 44 215 50 200 5-1 2 17 2510 2548 2098 2540 2202 2401 2475 2555 2283 1770 2510 2653 1972 2544 2556 2391 2922 2356 2690 2488 1561 2567 2659 2855 2496 1899 2337 2587 2474 2141 2659 1920 2190 2002 2377 TE-IV 2355 2467 2261 2293 2330 2329 2675 1915 2192 2481 3236 2733 1664 1794 2545 2612 2531 2777 1969 2510 2488 2105 2295 2441 1655 1799 2998 3356 2686 2756 2891 2564 1920 2379 2213 EPL 01468 'Undud&iiai B I O - T E S T vUei, 9nc. TABLE continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study In Albino Rats, Albino Mice, and Golden Hamsters Exposure Number 36 37 38 39 40 41 42 43 '44 45 46 47 48 49 50 51* 52 53 54* 55* 56 ' 57 58 59 60 61 62 63 64 65 66 67 68 69 70 Mean Chamber Concentration Data TE-I Chamber Concentration (ppm) TE-II TE-III 60 50 38 45 49 53 54 56 63 52 53 119"" 84"' 52 32 - 48 49 - - 48 56 54 46 45 43 49 60 48 53 42 48 42 39 43 171 190 198 193 278 128 219 238 211 195 199 298 255 206 105 - 210 202 - 196 347 243 218 240 191 210 185 211 214 172 209 216 190 199 2083 2451 2225 2208 2018 2686 , 2579 2835 2344 2640 1968 1659 2910 2498 2348 - 2565 2516 - - 2445 2141 2404 2333 2229 2077 2380 1659 2246 2394 196 3 2401 2722 2367 2448 TE-IV 2692 3307 3688 2638 2525 2310 2616 3203 1752 3149 2281 2569 1754 2573 1612 - 2528 2460 - - 2525 1576 2231 2306 2388 2306 2725 2457 2506 2428 - 2503 - 2328 2448 EPL 01469 Unduitruai B I O - T E S T 2alu 4vUei, 2no. TABLE continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study In Albino Rats, Albino Mice, and Golden Hamsters Exposure Number 71 72 73* 74* 75 76* 77* 78 79 80 81 82* 83 84 85* 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 Mean Chamber Concentration Data TE-I Chamber Concentration (ppm) TE-II TE-III 29 277 36 256 -- -- 51 203 -- -- 46 247 43 235 44 201 42 211 -- 47 201 47 200 -- 45 199 44 184 54 173 44 295 46 ' 175 47 197 51 200 50 230 53 201 53 220 68 230 38 186 41 172 50 222 35 187 46 189 49 202 48 222 51 2 05 49 196 3185 2499 - - 2585 - - 2397 2409 1448 2306 - 2385 2393 - 2565 2513 2664 3090 2396 2414 2191 2145 2883 2259 2624 2983 2410 2745 2354 2346 3100 2580 2546 2408 TE-IV 3516 2578 - - 2470 - _ 2633 2464 2400 - - 2006 2176 2529 2390 1083 2377 2236 - - - 2900 2333 2180 3513 2170 2875 2352 2046 2676 2306 2494 2542 * No exposure. EPL 01470 '3*uLubdal B I O T E 5 T 2ak Hue. TABLE continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study In Albino Rats, Albino Mice, and Golden Hamsters Mean Chamber Concentration Data Exposure Number TE-1 Chamber Concentration (ppm) TE-II TE-I11 TE-IV 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131* 132 133 134 135 136 137 138 139 140 30 193 50 220 49 200 44 193 59 198 52 216 50 198 54 222 58 200 54 195 57 203 46 202 49 197 50 184 53 187 48 213 49 192 48 197 38 198 49 197 54 211 53 195 48 195 53 210 50 198 -- 53 196 52 206 50 209 51 194 48 201 48 202 50 197 49 187 54 205 2393 2614 2566 2349 2497 2683 2573 2519 2392 2538 2592 2535 2922 2428 2529 2543 2461 2708 2488 2505 2787 2739 2512 2671 2467 - 2452 2551 2419 2515 2575 2512 2462 2424 2537 2245 1946 2534 2529 2357 2700 2706 2467 2502 2408 2642 2360 2455 2361 2428 2564 2355 2347 2640 2543 3080 2551 2644 2657 2500 .- 2453 2434 2480 2472 2753 2445 2440 2343 2590 # No exposure. EPL 01471 Dtuhu&Ual B I O - T E S T Jaluytcuvuci, 9tic. TABLE continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study In Albino Rats, Albino Mice, and Golden Hamsters Exposure Number Mean Chamber Concentration DaLa TE-I Chamber Concentration (ppm) TE-II TE-III TE-IV 141 142 143* 144 145 146 147 148 149 150 151 152 153 154 155* 156 157 158 159 160 161 162 ' 163 164 165 166 167 168 169 170 171 172 173 174 175 * No exposure. 45 57 - 49 48 51 47 49 52 51 47 48 48 52 - 47 50 45 49 45 53 58 52 52 49 52 48 49 48 54 49 49 50 48 51 196 177 - 223 197 218 207 223 193 200 189 194 197 206 - 202 184 192 134 196 179 181 195 187 200 201 199 193 207 205 191 209 197 194 199 2535 2594 - 2561 2500 2552 2541 2613 2444 2627 2413 2583 2467 2459 - 2554 2457 2240 2540 2687 2384 2484 2580 2488 2583 2520 2479 2472 2932 2528 2487 2478 2468 2367 2487 2391 2440 - 2480 2551 2352 2523 2352 2524 2654 2441 2435 2409 2493 - 2231 2294 2760 2600 2264 2664 2456 2815 2669 2755 2353 2667 2545 2729 2668 2488 2339 2532 2512 2496 . EPL 01472 i B I O - T E S T Jab '<yusd, Una TABLE continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study In Albino Rats, Albino Mice, and Golden Hamsters Exposure Number 176 177 178 179 180* 181 182 183 184 185 186 187 188 189 * 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 * 207 208 209 210* Mean Chamber Concentration Data TE-I Chamber Concentration (ppm) TE-II TE'IIl 49 198 51 51 203 49 201 -- 51 204 50 193 57 171 51 203 48 199 49 209 50 202 47 205 -- 48 198 50 196 51 200 51 215 50 204 47 200 48 202 50 198 49 199 50 201 48 200 48 204 48 202 50 206 53 194 50 199 -- 49 200 46 209 49 203 - 2534 2618 2573 2645 2347 2396 2364 2501 2328 2397 2537 2400 - 2431 2350 2452 2633 2447 2439 2377 2386 2457 2585 2473 2515 2459 2550 2620 2504 * 2593 2482 2521 , TE-IV 2536 2673 2640 - 2347 2464 2580 2355 2380 2392 2545 2524 - 2272 2400 2540 2270 2408 2440 2440 2564 2656 2672 2600 2413 2640 2478 2397 - 2528 2424 2516 * No exposure. ** No sample. EPL 01473 ' 1 y*cLtiual B I O T E S T JtaU mi&L, Pw. TABLE continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study In Albino Rats, Albino Mice, and Golden Hamsters Exposure Number 211 212 213 * 214* 215* 216 * 217* 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 * No exposure. ** No sample. Mean Chamber Concentration Data TE-I Chamber Concentration (ppm) TE-II TE-III 48 49 - - . _ . 48 49 42 46 51 51 43 44 54 51 49 49 52 55 51 50 54 - 58 56 56 51 43 46 50 49 51 51 207 205 - - 218 204 203 185 193 184 160 174 208 205 192 201 210 208 204 196 202 - 202 191 208 202 168 184 190 203 199 203 2577 2613 - _ _ 2288 2565 2481 2258 2380 2280* 1920 2073 2473 2558 2022 2542 2699 2475 2405 2597 2576 - 2540 2376 2300 2556 2481 2685 2366 2607 2420 2638 TE-IV 2428 2585' _ _ 2480 2445 2440 2410 2364 2440* 2800 2680 2480 * 2400 2640 2460 2333 2348 2370 2576 ** ** 2420 2084 2584 - 2380 2413 2428 2536 BPL O1474 ^B'O.TISTA* '-*iU TABLE continued TEST MATERIAL: Vinyl Chloride (Ethylene Derived) Chronic Vapor Inhalation Toxicity Study In Albino Rats, Albino Mice, and Golden Hamsters Exposure Number 246 247 248 249 250 251 252 253 254 255* 256 257 258 259 260 261 Mean Chamber Concentration Data TE-I Chamber Concentration (ppm) TE-II TE-II1 48 195 50 203 50 200 51 197 - 213 40 228 44 219 59 207 59 199 -- 44 225 56 206 51 202 50 206 47 204 52 197 2458 2525 2528 2422 2800 2783 2680 2490 2635 - 2654 2487 2602 2480 2597 2718 TE-IV 2467 2436 2435 2375 2240 2176 2395 2372 2447 - 2460 2350 2512 2440 2730 2484 * No exposure.