Document Jr400wEo33oyaMM2Ry1Ew4Jrr

AR2RG -- #70 z fei - . : : cc: CR.. JR.. CBuarmgpebrell 33.. LR.. GBrroaandqwuaiyst RP.. JT.hisztiplfeetlon GC.. AH.. SRtooblitnzson 3K.. FG.. DKoruognhbteyr:g C-8_ COMMUNICATIONS MEETING OUTLINE, TALK & CHARTS " , C7./31E./80STEINER PERSONAL & CONFIDENTIAL 2 . 5 . EID079399 . : 000193 .3 LF C-8 COMMUNICATIONS MEETING OUTLINE . v C. E. Steiner " INTRODUCTION Sch-o8r'ts Cd-e8sirhaibslteoryproicnesTsFEqu&alFiEtPieMsanufacture ToxzCITY e oral toxicity - slightly toxic e Compare to other compounds skin contact - slightly to moderately toxic Inhalation toxicity - highly toxic o CCoomnpcaernetrattoioontsherfocuonmdpoiunndasrea are lower INITIAL BLOOD TESTS s O3uMrDaRteasults . RECOGNIZING EXPECTED OPERATOR QUESTIONS - A transition o SSohmoertdihsibsetloiryeveofbacsheedmicoanlspasitn eixnpdeursiternyceshowing why we are careful MEDICAL RECORD STUDIES e Nsotuedvieisdentcheoroofughhealth problem : PROVISIONAL AEL . ANTBohEtiLsycoevmtemriyftitrlemoewAhEnaLusmbesret ipsrotvoispiroontaelctAEpLeopofle0w.5h5o mpb work with C-8 every The lTdoaweyaspornovwiesioanraelmaAkEiLngandchgaonaglestoinreedquuciepmebnltoodandfluporroicneeduriess.the EQUIPMENT IMPROVEMENTS e GIonaglretdoienrtesducaeddietxipoonsurheoodtoasnodlisdtaCc-k8, airborn C-8 and C-8 solutions e ERlaiimsiinnagteDrWyeeirghAiirngsCuiptprliycIAncliedtsin C-8 hood e SReaaalitDiroynearl DLreyaekrs Windo- ws e IRnecmroevaisneg CV-e8ntiflrloamtiDornyerDurEixnhgausOtustages 2 . EID079400 000194 LAU . _2- PROTECTIVE EQUIPMENT Clothing and Gloves _ e reeds to be disposable to prevent secondary contamination. e An EOD is being prepared to evaluate clothing. e Different protection levels for 3 exposure classes Breathing e EcqounicpemnetnrtatiiomnpsrowvielmlentsstiwlilllrermeadiunceinaisrobmoernaereaCs-.8 but high C-8 e Breathing air will be installed - ultimate solution. e Comfo II air respirator with GMAH cartridge acceptable. TESTING Personal Air Samples Will Resample. Blood Samples oe FBrleoqoudenstampslaimnpgliwnigllisbenotresnuemceeds.sary. Area Air Samples ee WOifltlencoenxtcieneudeprtoovidseifoinnealpArEogLrebsesf.ore improvements. ho SUMMARY ee Pce-o8pliesthwteoorxbiklcoiondbg,utwiactnahdnCl2be8evehlgasenngdeelrneadelrlayslalfaeyclcycu.omrurleatleateorwgiatnihcjofblueoxripnoesurien e Althoupogthentthiiasl.has caused no health effects continued exposure is o our bn'aeAosxEtipLc,otsogaelondeadrlwasotbrolakerer.eresdtuocaenrdeodprurgcaeenviecenxtpfoalscuucorrueimsnueltaotleibvoeenllosiwnintnehebwlpwoororodkveiorsfsi.onal @e TIhtiswiwloilfllablrrseeoaqtuhriiernqeguieraqeiuriuposmreenortfescdphiiasrnpagotesosarbsltehfaotrpraocrteeerctbtaeiiivnnegjocdbloson.teh.ing and us One otchoenrtroilnlgirnegdiethnitsiehnatzairsd.needed -- your cooperation in ~ 6 EIDO079401 000195  C-8 COMMUNICATION MEETING The purpose of this meeting is to bring everyone up to _ date on our findings regarding C-8, our immediate program, and our long term plans. Most of you know that C-8 is a fluorochemical surfactant that is used for producing fine powder, dispersion, granular and FEP. It has unique properties that allow it to wet Teflon's surface, shorten reaction cycle time, stabilize dispersions and provide sites for reactions. It has been used for Teflon manufacture for over 25 years. Other chemicals have been tested but none : match C-8's properties. Four years ago it was introduced in . FEP manufacture where it was a manufacturing improvement. Let's look over the highlights of the Technical history of C-8. In 1965 tests showed that C-8 was slightly toxic when swallowed. This was not surprising. There is a dose level where almost every chemical becomes poisonous, even water. (Chart 1). This chart shows the oral toxicity of C-8 relative to some common chemicals. These tests vere done on animals, and represent what dose would kill 508 of the animals tested. I've scaled up the dose from test data to animal weights comparable to an operator's weight. You can see that C-8 is not as toxic as acetone. It has a lower toxicity like table salt. C-8, like table salt, can also be absorbed through the skin where it is about as toxic as it is orally. But, based on } this low toxicity, no change in our safety program was necessary. ! . EIDO79402 000196 s zm In 1969 it was found that C-8 was more toxic by inhalation, | Chart 2. This second chart shows the approximate concentration that will kill test animals in a 4 hour period. This approximate lethal concentration for rats exceeds anything we have measured in the plant. The highest level ever measured in the plant is about 1/4 of that level -- and that a 1.lmpm leak at the feed end of No. 3 dryer which has been repaired. The other C-8 concentrations are generally about 1,000 to 10,000 times lower than this so people working fn the sxes ses 20 immediate stfect. (U0 : However, since 3M informed us in 1978 of organic fluorine being detected in the blood of their employees who worked with C-8, we have been reviewing and expanding our C-8 program. We have concluded that personnel routinely exposed to C-8 will absorb it in their body. Tests at Washington Works show that blood fluorine levels which indicate C-8 levels generally correlate with potential job exposure. Repeated exposures can result in accumulation of C-8 in the blood. One of the things that we are studying with the blood samples is the rate that C-8 is eliminated from the body. Some of theold timers remember when C-8 was treated with less respect and they wonder "Why is it suddenly harmful now?" ~ EID079403 000197 . Ca- Throughout the chemical industries over the last 50 years this story has been repeated with the same disbelief but * often with more drastic consequences. For example, carbon tetrachloride was used to clean auto parts and as a fire extinguisher for years, and now it is Xnown to cause damage in some people and is used with care. The same story has been repeated several times for things like chloroform (which was used in cough suryp), methyl alcohol and other chemicals. The difference between the ending of the C-8 story and the others is that Du Pont is reacting while C-8 levels in the blood are low and before any damage is done in the body. The medical data show that no one has been injured by C-8 (Chart 4). The Medical Division after a thorough study has concluded that ". . .there is no conclusive evidence of an occupationally related health problem among workers exposed to C-8." All that was noted was a small increase in two liver enzyme levels. After 25 years of handling C-8 we see no damage among the workers. However, the potential is there -- C-8 has accumulated in the blood. Because of this accumulation we have decided to undertake programs to minimize accumulation of C-8 in the blood of new workers. . EIDO79404 000198 . Sa The AEL Committee of Haskell Laboratories has set a provisional Allovable Exposure Limit or "ABL at 0.55 mpb of C-8 in air. This very low proposal is based on a safety factor of B00 below the level where reversible liver effects were observed. An AEL is the same thing as a TLV or EGL -- it is a safe concentration in the air of a working environment. In order to meet the expected low AEL, equipment changes are necessary to protect from solid, liquid and airborn C-8. The next transparencies show the changes that have been . made recently to protect against C-8 exposure. To date we have: o Modified the Fine Powder/Dispersion ingredients addition hood to reduce C-8 emissions and bring the mixing operations into the hood. C-8 tools will also be stored in the hood where possible. ' Improved the C-8 addition hood exhaust stack. The hood exhaust stackwas close to an H & V inlet on the roof. Removed operations that don't have to be done in the C-8 hood --- like citric acid weighing. This has redwed exposure of concentration to the operators. The dryers have been improved also: o Air supply inlets have been raised to remove : -8 rich air from the ceiling. z EID079405 - 000199 so o Seals of No. 3 dryer doors and seams have been . improved. e Inspection windows have been added to reduce need to open dryer doors. We have also put guards inside the dryer that will permit using the exhaust fans to remove C-8 when dryers are being cleaned. This has reduced some C-8 concentrations, but more work is to be done; for example, we plan to cover injection pump tanks, seal openings in floor and vent oscillating feeder compartments, sealing No. 3 dryer fans. The next chart shows the three different protection levels required for three exposure classes: Low dry exposure, high dry exposure and wet exposure. A disposable gamentsof the appropriate design, gloves and air protection are recommended for each of these exposure classes. Sample gaments have been selected and an EOD will be run to evaluate this clothing. Tyveke vas selected over cloth or paper gaments because it is light fairly resistant to tearing, a good filter and disposable. Disposability is required to prevent secondary contamination when laundering. During this EOD, sample gaments will be tried and evaluated by operators and mechanics. c-8 will permeate all glove materials over a period of time. New flock lined latex gloves will be used in jobs where C-8 exposure is likely. Even these gloves will be permeated by C-8 over a period of time, so these gloves will be disposed of after each shift. ; } . EID079406 000200 . _6- Breathing protection is very important to reducing C-8 exposures. Equipment improvements will reduce airborn C-8 in most areas but there will still be areas where exposure, is possible. A COMFO II air respirator with a special GMAH cartridge is required as a minimum. Breathing air is better and will be available soon. The yellow 3M masks are not acceptable. I've had some questions on future C-8air samples and blood samples. Ve now have our baseline data and have mapped out the problem areas. The procedures are modified and equipment improved so C-8 exposures will be reduced. Blood sampling will probably be done on an annual basis in the future to define the real improvements in C-8 control. Let me summarize the items covered: C-8 is toxic, but it can be used and contrplled below the proposed toxic limit. In the past, people working with C-8 have accumulated organic fluorine in the blood and levels generally correlate with job exposure potential. Although this has caused no health effects, continued exposure should beminimized with controls. our objective is to reduce exposures to below the provisional AFL, and to reduce organic fluorine levels 3 in blood of exposed workers and to limit accumulation in new workers. . :. EID079407 000201 -7- This will require equipment changes that are partially complet It will also require use of disposable protective clothing and use of breathing air or respirators for certain jobs. One other ingredient is needed -- Total Division cooperation in controlling this material. & s EID079408 000202 ] CHART 1 ORAL TOXICITY (Doses LethaL To Asout 50% oF ANIMALS) AcETONE c-8 TABLE SALT METHYLENE CHLORIDE 0.2 (Mos) 1.0 (Doe) 7.2 (Ram) 7.2 (Ram) : 000203 8 . EID079409 . CHART 2 INHALATION TOXICITY (APPROXIMATE LETHAL CONCENTRATIONS FOR 4-HOUR ExPoSURES WITH RATS) -8 METHANOL 4 . 300 * MPM = MOLES PER MILLION -- SAME AS PARTS PER MILLION BY VOLUME, 000204 i . EID079410 CHART 4 MEDICAL STUDIES MepicaL Division 1/25/80 STATEMENT BASED ON LIVER ENZYME STUDY ==", , .'. THERE IS NO CONCLUSIVE EVIDENCE OF AN OCCUPATIONALLY RELATED HEALTH PROBLEM AMONG WORKERS EXPOSED T0 C-8." 3M MeprcaL DIRECTOR IN 3/14/80 MEETING WITH Du PONT STATED THAT THEY HAVE NOT IDENTIFIED ANY SIGNIFICANT INDUSTRIAL DISEASE RELATED To C-8 EXPOSURE. No EVIDENCE OF HEALTH PROBLEMS IN MORE THAN 25 YEARS USE OF C-8. HANDLING PRACTICES IN EARLIER YEARS HAD GREATER EXPOSURE POTENTIAL THAN RECENT OPERATIONS. CONCLUSION No CONCLUSIVE EVIDENCE OF HEALTH PROBLEMS RELATED To C-8 EXPOSURE, : 000205 : & * EID079412 =. : AD PRCO-T8ECETXIPVOESCULROETCHIIANSGSSumRy Class 1 DRY LOW EXPOSURE Disposable TYVER coat or smock . Class 2 DRY HIGH EXPOSURE Disposable TYVEX coveralls with hood or cap Dgilsopvoessab(loer olraatnegxe Bute omit unavailable) glDiosvpeossable latex Black rubber Hoots Class 3 WET EXPOSURE e Disposable coated TYVEK coveralls pants with hood or coated smock and coated Dgilsopvoessable latex * Hack nitber Boots + NOTE: Breathing air or COMO IT respirator with QRH cartridge is also recommended for all exposures, but are not included as part of this test. CES/ikm. 5/13/80 oo : : 000206 t EIDOT9417 SUMMARY e C-8 IS TOXIC eo PEOPLE ACCUMULATE C-8 NO HEALTH EFFECTS AT PRESENT LOW LEVELS o GOALS: o TO REDUCE EXPOSUREBELOH AEL TO REDUCE ORGANIC FLUORINE IN BLOOD : o REQUIRES: EQUIPMENT CHANGES . o DISPOSABLE PROTECTIVE CLOTHING AND GLOVES o BREATHING AIR OR COMFO 11 COOPERATION 3 000207 ' EID079418 - mans . E. I. pu PonT DEomNroEnsMreOs UR&S COMPANY PancsPa.oOn.cB,oxwi.12V1a7. 26161 CC: E. D. Champney, Jr. - Wilm. DJ.. KW.. RDauinnceasn/R-. WiM.lm.Shepherd-Wil RR.EJ!. BPuurtgnearm PERSONAL AND CONFIDENTIAL September 30, 1980 70: : FROM: 77.0x7F.0 JORDAN 3. s. LINDELL "DORDRECHT WPAASUHLITNHGITSOTNLEWTOROKNS * Y|* TEFLON DIVISIONS = C-8 (FC-143) CONTROL Attached is a copy of the "Status and Program" that was reviewed at our Teflon Divisions' C-8 meeting on Sept. 25, 1980. Please let me know if you have comments or questions. Attachment PT/nsw EID077237 E There's worl of tingswe're doing something sbout 000208 Fran EenmD oy EE E3EE2EEE EEEzEERsEEEgE IEEeIEEiRRcEEEREcEEEEop . 5F8E5E8RgE3aeaE3ac%E:3H382E3EEE EE g gLg axEg , g8Ed d Sf8g Ef3EE5zdE8g1E l3 Luong rE 3ggw 5BB5%Ed32 553: 3 IgEREEs 85E5z '. gEg2 . 8 ggo 3gE. S5 le2 5 E1E2 3 A5lnei Ei | 2 i3=v =z 4 J 4=3 Eos. sie an ewne [B< 13 wa ws 3ybd | EID077238 000209 e p HE i u m 5k ii H il | ai l i h ] ! I " ft -. or res J . 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