Document Jm0xReXYzGVR8NznxgqDY9br

WORLD HEALTH ORGANIZATION INTERNATIONAL AGENCY FOR RESEARCH ON CANCER IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 11: Cadmium, Nickel, Some Epoxides, Miscellaneous Industrial Chemicals and General Considerations on Volatile Anaesthetics Summary of Data Reported and Evaluation Epoxides Diepoxybutane Diglycidyl resorcinol ether Epichlorohydrin 3,4-Epoxy-6-methylcyclohexylmethyl-3,4-epoxy-6-methylcyclohexane carboxylate cis-9,10-Epoxystearic acid Glycidaldehyde Glycidyl Oleate Glycidyl Stearate Triethylene glycol diglycidyl ether Miscellaneous Industrial Chemicals Benzyl chloride -Butyrolactone -Butyrolactone Dinitrosopentamethylenetetramine 1,4-Dioxane Ethylene sulfide Last updated: 13 April 1999 DIGLYCIDYL RESORCINOL ETHER VOL.: 11 (1976) (p. 125) 5. Summary of Data Reported and Evaluation 5.1 Animal carcinogenicity data Diglycidyl resorcinol ether was reported in a preliminary communication to be carcinogenic in mice by skin application and in rats by subcutaneous injection. No carcinogenic effect was observed in a further long-term skin application study in mice. No evaluation can be made. 5.2 Human carcinogenicity data No case reports or epidemiological studies were available to the Working Group. Subsequent evaluations: Vol. 36 (1985); Vol. 71 (1999) For definition of Groups, see Preamble Evaluation. Last updated: 25 March 1998 3,4-EPOXY-6-METHYLCYCLOHEXYLMETHYL-3,4-EPOXY-6METHYLCYCLOHEXANE CARBOXYLATE VOL.: 11 (1976) (p. 147) CAS No.: 141-37-7 Chem. Abstr. Name: 4-Methyl-7-oxabicyclo(4.1.0)heptane-3-carboxylic acid, 4-methyl-7-oxabicylo(4.1.0)hept3-yl methyl ester 5. Summary of Data Reported and Evaluation 5.1 Animal carcinogenicity data 3,4-Epoxy-6-methylcyclohexylmethyl-3,4-epoxy-6-methylcyclohexane carboxylate is carcinogenic in mice by skin application: it produced skin carcinomas. 5.2 Human carcinogenicity data No case reports or epidemiological studies were available to the Working Group. Subsequent evaluation: Vol. 71 (1999) 091-34epox6metcyl For definition of Groups, see Preamble Evaluation. Synonyms q Chissonox 201 q -Dicyclodiepoxycarboxy1-3,4-epoxy-6-methylcyclohexylmethyl)-ester-3,4- epoxy-6-methyl-cyclohexenecarboxylate q EP 201 q Epoxide 201 q 3,4-Epoxy-6-methylcyclohexanecarboxylic acid,(3,4-epoxy-methylcyclohexylmethyl)ester q 3,4-Epoxy-6-methylcyclohexylmethyl-3',4'-epoxy-6'-methylcyclohexane carboxylate q 4,5-Epoxy-2-methylcyclohexylmethyl-4,5-epoxy-2-methylcyclohexane carboxylate q 6-Methyl-3,4-epoxycyclohexylmethyl 6-methyl-3,4-epoxycyclohexane carboxylate q (6-Methyl-3,4-epoxycyclohexyl)methyl 6-methyl-3,4-epoxycyclohexane carboxylate q 4-Methyl-7-oxabicyclo(4.1.0)heptane-3-methanol-4-methyl-7-oxabicyclo(4.1.0)heptane- 3-carboxylate q Unox 201 q Unox Epoxide 201 Last updated: 13 April 1999 cis-9,10-EPOXYSTEARIC ACID VOL.: 11 (1976) (p. 153) CAS No.: 2443-39-2 Chem. Abstr. Name: cis-3-Octyl-oxiraneoctanoic acid 5. Summary of Data Reported and Evaluation 5.1 Animal carcinogenicity data cis-9,10-Epoxystearic acid has been tested in mice by skin application and in mice and rats by subcutaneous injection. The limited amount of data do not indicate that the compound is carcinogenic. 5.2 Human carcinogenicity data No case reports or epidemiological studies were available to the Working Group. Subsequent evaluation: Vol. 71 (1999) Synonyms q cis-9,10-Epoxyoctadecanoic acid q cis-9,10-Epoxy octadecanoate q Epoxyoleic acid Last updated: 13 April 1999 GLYCIDALDEHYDE VOL.: 11 (1976) (p. 175) CAS No.: 765-34-4 Chem. Abstr. Name: Oxirane-carboxaldehyde 5. Summary of Data Reported and Evaluation 5.1 Animal carcinogenicity data Glycidaldehyde is carcinogenic in mice by skin application and by subcutaneous injection and in rats by subcutaneous injection. It produced malignant tumours at the site of application in both species. 5.2 Human carcinogenicity data No case reports or epidemiological studies were available to the Working Group. Subsequent evaluation: Vol. 71 (1999) For definition of Groups, see Preamble Evaluation. Synonyms q Epihydrinaldehyde q Epihydrine aldehyde q 2,3-Epoxypropanal q 2,3-Epoxy-l-propanal q 2,3-Epoxypropionaldehyde q Glycidal q Glycidyl aldehyde Last updated: 13 April 1000 GLYCIDYL OLEATE VOL.: 11 (1976) (p. 183) CAS No.: 5431-33-4 Chem. Abstr. Name: Oxiranylmethyl ester of 9-octadecenoic acid 5. Summary of Data Reported and Evaluation 5.1 Animal carcinogenicity data Glycidyl oleate has been tested in a limited study in mice in which subcutaneous injection produced a low incidence of local sarcomas. This result is insufficient for evaluation. 5.2 Human carcinogenicity data No case reports or epidemiological studies were available to the Working Group. Subsequent evaluation: Suppl. 7 (1987) (p. 64: Group 3) For definition of Groups, see Preamble Evaluation. Synonyms q 2,3-Epoxy-l-propanol oleate q 2,3-Epoxypropyl ester of oleic acid q 2,3-Epoxypropyl oleate q Glycidol oleate q Glycidyl octadecenoate q Oleic acid glycidyl ester Last updated: 25 March 1998 GLYCIDYL STEARATE VOL.: 11 (1976) (p. 187) CAS No.: 7460-84-6 Chem. Abstr. Name: Oxiranylmethyl ester of octadecanoic acid 5. Summary of Data Reported and Evaluation 5.1 Animal carcinogenicity data Glycidyl stearate was tested in mice by subcutaneous injection; it produced no significant increase in the incidence of local tumours. 5.2 Human carcinogenicity data No case reports or epidemiological studies were available to the Working Group. Subsequent evaluation: Suppl. 7 (1987) (p. 64: Group 3) For definition of Groups, see Preamble Evaluation. Synonyms q 2,3-Epoxy-l-propanol stearate q 2,3-Epoxypropyl ester of stearic acid q 2,3-Epoxypropyl stearate q Glycidol stearate q Glycidyl octadecanoate q Stearic acid glycidyl ester Last updated: 25 March 1998 TRIETHYLENE GLYCOL DIGLYCIDYL ETHER VOL.: 11 (1976) (p. 209) CAS No.: 1954-28-5 Chem. Abstr. Name: 2,2'-(2,5,8,11-Tetraoxa-1,12-dodecanediyl)bisoxirane 5. Summary of Data Reported and Evaluation 5.1 Animal carcinogenicity data Triethylene glycol diglycidyl ether was carcinogenic in a limited study in mice by intraperitoneal injection: it increased the incidence of pulmonary tumours. 5.2 Human carcinogenicity data No case reports or epidemiological studies were available to the Working Group. Subsequent evaluation: Vol. 71 (1999) For definition of Groups, see Preamble Evaluation. Synonyms q 1,2-Bis[2-(2,3-epoxypropoxy)ethoxy]ethane q 1,2:15,16-Diepoxy-4,7,10,13-tetraoxahexadecane q Epodyl q Ethoglucid q Etoglucide q TDE Last updated: 13 April 1999 BENZYL CHLORIDE VOL.: 11 (1976) (p. 217) 5. Summary of Data Reported and Evaluation 5.1 Animal carcinogenicity data Benzyl chloride was tested in mice by intraperitoneal injection and in rats by subcutaneous injection. It was carcinogenic in rats, in which it produced local sarcomas. 5.2 Human carcinogenicity data No case reports or epidemiological studies were available to the Working Group. Subsequent evaluation: Vol. 71 (1999) Last updated: 25 March 1998 -BUTYROLACTONE VOL.: 11 (1976) (p. 225) CAS No.: 3068-88-0 Chem. Abstr. Name: 4-Methyl-2-oxetanone 5. Summary of Data Reported and Evaluation 5.1 Animal carcinogenicity data -Butyrolactone is carcinogenic in mice by skin application and by subcutaneous injection and in rats by oral administration and by subcutaneous injection. It produced tumours at the site of administration in both species. 5.2 Human carcinogenicity data No case reports or epidemiological studies were available to the Working Group. Subsequent evaluation: Vol. 71 (1999) Synonyms q 3-Hydroxybutanoic acid, -lactone q 3-Hydroxybutyric acid lactone q 3-Hydroxybutyric acid, -lactone Last updated: 13 April 1999 DINITROSOPENTAMETHYLENETETRAMINE VOL.: 11 (1976) (p. 241) CAS No.: 101-25-7 Chem. Abstr. Name: 3,7-Dinitroso-1,3,5,7-tetraazabicyclo(3.3.1)nonane 5. Summary of Data Reported and Evaluation 5.1 Animal carcinogenicity data Dinitrosopentamethylenetetramine was tested in rats by oral administration and intraperitoneal injection. No carcinogenic effects were observed. 5.2 Human carcinogenicity data No case reports or epidemiological studies were available to the Working Group. Subsequent evaluation: Suppl. 7 (1987) (p. 63: Group 3) For definition of Groups, see Preamble Evaluation. Synonyms q Aceto DNPT 40 q ChKhZ 18 q Dinitrosopentamethenetetramine q Dinitrosopentamethylenetetraamine q Dinitroso pentamethylenetetramine q Di-N-nitrosopentamethylene tetramine q 3,4-Di-N-nitrosopentamethylenetetramine q N,N'-Dinitrosopentamethylene tetramine q N,N'-Dinitrosopentamethylenetetramine q N1,N3-Dinitrosopentamethylenetetramine q DNPT q 1,5-Methylene-3,7-dinitroso-1,3,5,7-tetraazacyclooctane q Mikrofor N q Micropor q NSC 73799 q Opex 80 q Unicel ND q Unicel NDX q Vulcacel B-40 q Vulcacel BN Last updated: 25 March 1998 ETHYLENE SULFIDE VOL.: 11 (1976) (p. 257) CAS No.: 420-12-2 Chem. Abstr. Name: Thiirane 5. Summary of Data Reported and Evaluation 5.1 Animal carcinogenicity data Ethylene sulfide was carcinogenic in a limited study in rats by subcutaneous injection: it produced local sarcomas. 5.2 Human carcinogenicity data No case reports or epidemiological studies were available to the Working Group. Subsequent evaluation: Suppl. 7 (1987) (p. 63: Group 3) For definition of Groups, see Preamble Evaluation. Synonyms q 2,3-Dihydrothiirene q Ethylene episulfide q Ethylene episulfide q Thiacyclopropane Last updated: 25 March 1998