Document JYjNk3N8yw22KgJOYKGXyQDa
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by
Dr ?. S, Edit.; (Consultant)
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BioohrvAc
Tin h*s
liscussed at tho Tenth PAO/.vFO Exp.'-rt Cemittee on Feed
Additives in
(FAO/,.';iO, 1957). It Is still uncertain whether tin plays
any err;-: dial biological role in the to-'y. It is present in small an cunts in
all hue an and
:..al organs funs norru.1 adult .'car contains about 952 ry. Andreis
fed on iin-conv>':ring food nay tend to nccunulat0 a body lead. Tin is poor!
absorbed from the alimentary vr?ot anils chiefly oxcreicd by the f: sees with
additic-nl slow elimination in the urine (Frowning, 1969). Adninistrai-'or. of 2 rg
tin daily 00 rats in their drinking water was foiled by 90,9 excretion in the
faeces (Fllnn and Inouye, I92O). Fore than
of tin tartrate was excreted in
the faeces (Schryvar, 1979). Tin tends to be retained in the liver, kidneys,
bones, least in the brain (Browning, 1559).
Acute toxicity
Tin itself, taken crally, is praticslly innocuous but inhaled dust or fuue causes benign symptom-less pneuir.ocor.osis. The inorganic salts are of low toxicity but allryl derivatives are highly toxic.
Guinea Digs survived cn a diet containing 770 ppm tin salts (Schwartzs and Clark, 1917). The LD by i.v, injection appears to bo ICO rr$ tin (Seiftor and Rarr.bouse :, I9-V9), death occurring from CAS and C-.I. tract injury. Tne spleen
The isiue uf this document ac'.-s not conotituto
fo.'.nal
It 6hould not be reviewed,
nbetrected or gmted withec: *;ie r.yonmcnt ot
Iitt,. 0* 1I1,iUittuj
!) Gii'.cnrstion. Autiors alone
pro roeponabln (or viovv- exprueeud In ei{, ...d
ari'clcu.
Cc donun'ont ns constitue pee one publication. II ce dent faire I'obiet d'accun eompto rendu 00 risum6 ni d'ouCL'iio citation emis rau:uM--*'tirm do rOrpnnisnt'Oii i-'OiV.'lale do 13 Sarto. Los o;i null's rxpiiniiios dans les ertiCle-3 Sign-ds n'eng/v ufU C;ja lours puleivs.
. ASI 00004267
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10,.-,.. i-v
1 ML.: *'y of Real . I MLM:.- , Japan ,V.-0?
Chr T c'rr.i 3. -e.-,o.'ui ' to tin duet or f r.os c'.-'m.:' h'uLrn pr.eunooorie:..'
(i Ci'
~:s , id
cin the lu*.g M `-h li". t'e
nbsc,plica co;Ir: to in.so] ' eiilty
up ,
Red roning ircicd ms Move Lem reported
Japan from tin coni:. Med in
tinner', -..or. to Juic-., Value;? lay heir,;, .:n 8p - 2l0 ppm. ,YL Okayama, 7 parsers
out of 9 re poicoac;' in I9J9. Tn Tokyo, 1 care ups report-:-! in I969 follow ins
an intake of 2,j-7 PP-'i (Ho jura, 19--9)- Anoohor iirri/j'.. rhas teen reported
previously in 15 Japanese students from canned orf.rye juice vjith another
8l cnees eieewhera. The ay:.;.toms reported wove vomiting, diarrhoea, fatigue
Vid headache, 'Me tinned products ehevred a range of tin center.!. fro;r. 73 to
339 (Ministry of Health paid Welfare, Japan, 1963).
Long-term a tudJ --s Rat
A group of 13 male and 17 female rats were fed on a diet ccntainir g 2oj chlorostunnate for over one year. 16 miles and 17 females acted as controls. Mammary adenocarcinoma, ere uterine sarcoma and one adenoe: vcinoma near the javj occurred in the test group. The difference in tumour incidence '..as probably not significant (Roe et al., 1965).
Mouse
1 Groups of mice received over several generations in their drinking water sodium chlorostannate either at 1 GOC or 5 000 ppm Sn or stannous oleute in their diet at 5 000 ppm. Mo adverse effect vierc noted nor was there any difference in tumour incidence between test and control groups (waiters and Roe. I9S5).
Acute toxicity
Animal
Route
mouse rat Rabbit
oral oral ore l
t
STAKHOUS CHLORIDE
"50 mg/kg bodyweight
1 200 700
10 000
Reference
Calvery, iMp Calvary . 19-'l-2 Eckerdt, 1909
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Bro'^in;- ,, E. (l.^-oy) , Toxicity of Iixiui-d-.yi-.l Kotele, Butt-eonxorthe, Loron Calvary, F.O. (ly1^), Food Roc,, 7, dip
Chcftsl, ;I, (lC\'/7), \,'o:-.v:iny Pop;:!1 over.ittcd to Kth Session Codex Crxi"ittee on
Food Aiditi',c ^, AmLun
Ecknrdt, (].v--v')> Z* Untcro, Lohoucr.i. , lB, ]QJ FAO/WIIO (1957), \v.! 10 Tachii. Ron. I-pries lio~fO
FDA (193:-) In Food boms Injection'-; end Int-xications, Car raid Pro0.0, 2nd e-d. . Chrrpniyn
Plinn, F.B. sxd Inouyo, J.M. (lydS), J. Amor. Fed. A^s. , op, 1070
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