Document JVmLrn5ke84VV8DBzE0OZ7Kv

I c i 1- Once recently, the same authors (1968) again confirmed thenonconformity between the cytotoxic, hemolytic and fibrogenic proper ties of different types of asbestos. Klosterkotter (1968) also established that the decrease of lactic acid in the tissue culture which contacted with different samples of asbestos does not correspond to the fibrogenic ability of the latter. Unlike Vigilant and Pernis (1968) Schllpkotter established that the hemolytic activity of four forms of asbestos Is identical. PolyvlnylpyridlncN-oxide (PVN-O) retards the hemolytic activity of aphlbolic asbestos; however, it does not affect the activity of fibrosis. Vigilant and Pernis (1968) showed that PVN-0 and EDTA turned out to be incapable of protecting the macrophage from cytoxic action of asbestos. On the other hand, in the experiments of Klosterkotter (1968) a certain decrease in fibrosis is achieved on subcutaneous introduction of PVN-O. .. ... , r . . ` l .. ,.., . .: :' ; In the carefully presented work of Roe and Harlngton ' ` v % \*. . i .with the aid of histoehemical and enzyme methods it was shown j pif:- S ^^Wozniak (1966). ?howe<^tha^ of dry tissue) in the^'ouiture of the isolated lungs, corresponds .. < ^anavrioneaiclned^cnryBor Thus, in spite of the contradictions in the data of the .y-. various authors, It is possible to draw the conclusion that asbestos exerts a definite damaging action on macrophages by <y changing their exchange and'changing the rate' of increase in and nature of the development of these cells. W*v- 15V - 6000 0876 PRODUCED BY FORn