Document JNavkRKmoMampk98KG4QGNwy6

' t""** ;-**.&$&%**<#/.'Jl.;.'. /'*' W' - %gf.'1 W. $p, $$*: *&&> >'#*,f- -f. :;*, \$>5v '' . . mr . \'&' I Hand-out VinvliChi oridq V'orknhop it; ,t(;: V'.U.O. Lyon 2V-S5 Jur.c'197/1 -1 -I !: ,. ., IW>^ Xr'"'-' t; i r 0. ir tr< JUL 1 i`.\'4 VV. M, ftt:. *rri.' by J.H. Kecking, Chief^Medical Officer Che1 lfh'otherlnnd:i HefInery "and Cheraio K.V. .* * F.V.C. in being produced by Koval Dutch S i, f; 11 in its plant in Itottordnci - JVrnis the A`eth< riand.s since fl9'i9* Initially the product ior. being n few bund rod loir* yearly, it gradually increased to f-0,GCO ton;;. The original plant was taken out of certain, ion-in ecrly7 1993 -'her. a i-.cw one war. started. The yearly output ia now sonewhi'j-o in the noi ghbourhood c.f lcQ,OJD ton.;, The procerfl of the firr-t plant way a continuous one with 5 reactors, each of which vaa opened end cleaned by water jet every 3 wee Its, The new plant which war, com r.i onioned in iy{>7 was on a batch process with initially 15 ar.d now since 1972 a total of;3" reactors with a cleaning cycle of 12-15 hrs. hid 1072 a ruction gadget war. installed ovr the r.ar.holcs, to reduce drastically the amount of vapour when they are opened. Lit ar.ing is by water jet m before. v '' ' ' ' . -. ' ' I'roduc t i on of V.C.M. wan .''topped in July 1971. Ever since then it ; > being piped from u nearby plant, not belonging to our group. i&. yy' &&.' Since 19'<9 a'; total of; 35? process operators have b^n engagr.,* on work with V.C.M. and P.V.C., of who;* 101 loss than a year, 59 less than 2, 22 >S5 than 3, 10 ler:: than 5, 3p less than 5i 52 fror.i ( -10 yrr., 19 from 11-15 yrs and fl longer thnn/20 yrs*. Figure 2 shows how the present labour force is built up in 5 ycarjage yroupni'272 workers out of the total of 350 ere still at work in our workajL-at Pernls, " have been retired or wont with resignation. Out of thisgeroup only or.c tr.an died in February 1972 at the age of '>2. lie had Wen with the company 23 yrr.. Cause of death was myelofibrosis and par.cylo pen la. Front 19'*9 1935 ho worked in the F.V.C. plant with exposure to V.C.M. D.C.A (dichlooraoth '.r.e) . Fro:; 1955 bill 1V-0 l`.o worked in a H.F. Alkylation plant with exposure to bomttu.e. Fro.;' then onwards in a sulfusji sat ion plan.*, with exposure to SO-., Hy.9 , ar.d .0;etha:;el a.c.i no. During his ti'Ofttm.cni, a splenectomy was carried out during which it was found that the liver, had a nor.-a1 healthy aspect. Microscopy of the spleen disclosed a few recognisable fo) 1 i nr. 1., n r*-d pulps with very many red cells ar.d rather large s.or.orucb ':- o.-.e*;, littl" c t op] a--1a end kidney-be an like, ur.alci with a cl orc-ni ttod ch.vcr > t i r.e structure. Th.ere w-ej-o nlra cany of these cells in the si nur.oidr., Durlr.g It i n illner.i the liver was enlarged, but never rose than ft few fingers. In both axillae glar.ds were enlarge-'. /,r.d increased in mrcber. lliopf.y showed n riniJar ntruoture or- the spleen. rur.ctuie of toner.as'rov dir.clored cstj-e.r.ely tough be:in .'structure ar.d very little narrow with jonl y a few colic. 7 hror.harytcr. .h.ving the observe, t i on which, lasted fron il July 19b5 till hi.*; death on 21 February 197*J- varied l.f-tween 70,000 and 5i ,DOT. Alkaline ft>sfat .1 se was rec.ct ir.ers r.or.ewhat raised, O.T.'r. and I'.f.'s were always found to be r.urnal. Vs do sot. think there is a connection with bin work in the F.V.C. plant, nor daea the Dutch inspect oralc of factories. V,),, /. ///. %mr co M 0- W P i$r S vSt t-.i . V33" #jifeP*', r&C i-:- R&S 025714 Since r.id `107*^ ft tine weighted l.'i.V. of ^0 ppm in adhered to. r.efore that line A.C.CwI.H. advise of i.'Q0^pp."> ''"' * he guiding figure. I.cv.ihi Are constantly being chocked by. spotisavpl ing; (G.U.C. analysis) and cumulative 'JO minute ..ar.pl ing^-inco1' Since January 197G leak .'detectors (ire bei:ig u:cd, based on the fla.T.c-ionir.ation coll principle, A system of fixed sampling on strategic point:) will be ir. (tailed in September. Apart from thig,0 hrs persona 1 nor: pi inp pot under way fourtr.ight Ago. fie.-nil t a of a few early one a c.io disclosed in the Appendices, As for periodical examinat ions. k/er since 1993 thc-re have been pf-rfoi-r'-d f.a A once ft year routine. From the beginning there included cheat X-ray, urine. Albumen, Reduction, Sediment, illoo:!, vhite cell:;, red cell:,, Hb, differential counts ar.d sudimentat ion rate, a work hir.tory and physical examination. In 19','S ft rerun ohenopram was included conn i s t lag of T.F-. Ca, Choi, Glucose Urea, Uric Acid Creatinine, Total hi 1 i rubino, Aik, phophata.*,e , 1..').!!., GG;'T And SOOT. In addition X-rays of hand:1 were taken. Since about G month') platelets (thrombocytes) arc counted, and VGT tests carried out. : ' 1 "* A norhidity analysis over the years 19G6 - 1973 (incl.) 'vs carried out, matching the PVC group of workers vith a comparable one on the refinery side. It includes following l.C.D. codec: 1 fj 0 - 17*i,9 mal igu ant growth of respiratory and digestive tracts, :k:n, tissues r.r.d bones. ^AbO - 51b,9 diseases of-the rospira.tory tract. 570 - 577,9 diseases. ofJ'; liver, gall bladder and pancreas, 5C0 - 593i9 diseases ofjl. urinary tract. ' ''' , *\ * Hatching includes following qualities. age (5 year groups) , nationality, sex, number of years working in Pernis works (5 year groups),3hi ft or day duty, collective contract or not, marital status . For cach-.persor. vo:9:ing a '-hoi <- year in 1VC/VC plants, a correlated one on the refiner'/ side was selected. Those for whom r.o rc* left out. u*c 3. wit!) SAMO co: '.trol gr r.:p of perrons di* idir.g examination.. From previous three groups accord i::o to th.e year of raises we kno*. the st. indeed dev: at iom 0 f the various parameters for.thc Ft: mis population i.s a whole. These wore- u1....! to tort for significant differences. Following paramoleru wore found to bo different. 191 f t g. CaJ-i Uric Acid 1973 fig. 0 197G fig. 7 Cat* Uric acid create All:, fosf. SOFT SCOT Uric acid V.C-. lower than control V.C. lower than control ws : b-'' r: Only uric. Acid in significantly higher in nil } years, Cn.1 * in the years V)~Z and 1973- '$*. The npe distribution is shown in figure .All values in Table 71 Undoubtedlv norc information is required covering a larger span of yearn. To conclude 1 would like to oontjon that together vith the Dutch In rpectorate of Factories a task force has h,,f,n forced which will collect data covering work histei-v , personal a:rl fnr.il)- h i sto;-y, rhyr.ir.nl ex..~.inat ion rs 1 1 nboratory finding.*' as Mentioned above covering a group of :.o:r.o liliO '*ori,,,rs in the Netherlands. History covers such ite.-.i as Knynaud di r.care , alcohol i r:i, hoth-.es and spare tir.'e activities, fertility, sterility, still birth, abortion, fa-ding habits and the like. . Tor those interested ,a brought a few copies in Dutch. f- v >y* 30 03 0ro 01 ^n1^ <J1 R&S 025716 < r> R&S 025717 8I.ZSS0 syy R&S 025719 jt J I ! i R&S 025721 V i. ? VC/ R&S 025723