Document JNaL1yvegJvXeMjZ0ZjO9G27K

Nr. C. E. Staff Bakellte Company 30 East *2nd Street Pew fork IT* Maw York Hr. 0. 0. Himmler December 7, 1953 Dear Charllat It la of Interest that In 19*1 our group at Mellon Institute foil several vinyl films for ninety days to dogs and groups of rats* Four samples ef films were utilised* made up from "Vinylite" resin VYOT, Sample 7-40*3 contained stabiliser 0-15* 0*75%} dibutyl "Cellosolve" phthalate* 27*000; and methyl "Cellosolve" oleate* 3*000. Sample 7-*159 contained calcium stearate* 1.000; methyl "Celloeolve" oleate* 3.0001 and trlereeyl phosphate# 37.000. Sample F-*l6* eontalned stabiliser 0-22* 1.000; dlbutyl "Cellosolve" phthalate* 27*000; and methyl "Celloselve* oleate* 3*000. Sample F-*l65 eontalned lead stearate. 1.500; dlbutyl * ."Cellosolve" phthalate* 27.000. and methyl "Cellosolve" oleate* 3 000 As yea know* there were very minor amounts of other somponents in the above. the result of this study* which consisted of 90-day oral dosea to dogs in meat at 1 gm./kg./day and to rats as aoutous extract at 19** fft./kg./day* showed that films 7-*0*3* *159* *16** and *165 save no Injury except slight biochemical Changes, fha last gave detectable load In the bleed, this Study would Indicate that these films were ef a very law order of toxicity. Plasticisers - Ms have done an enormous amomat of work cm DO? which hisheen pubUshed. In this application ucc 063339 Mr. C. S. Staff -a December 7# 1953 we would bo principally latorostod In oral toxicity, The single oral LDco dose for SOP la 30*6 ga./kg. body weight for rats. In regard to trl(2-ethylhexyl) phosphate the single oral UDwa dose la 39.8 gn./Vg. body weight. Flastlolser R2H, when tested on rats, a single oral dose of 63 gu./kg. In lard killed none of nine rats. You will see that all these plastlolsers have quite a low order of toxicity. Stabilisers - The tin stabilisers are nueh nore toxle. 7or exanple# dlbutyl tin dllaurate or stabiliser 0-22 has a single oral LXfcn dose of 1.2b gu./kg. body weight. Dioctyl tin dlchlorlde has a single oral LDcq dose of 0.19 ga./kg. body weight. The various lead stabilisers used In vinyl files are not highly toxic by single oral Ingestion. Stabiliser C-2, or calclea ethyl acetoacetate, Is of a low order of toxicity as evidenced by the single oral LD** dose of 9.93 ge*As* body weight. X would hate to predict what the effect night be on a cow eating a vinyl file of any sort. This opinion is bas d upon the recent discovery of the adverse effect on cattle of extrensly nlnute anounts of chlorinated naphthalenes. X should think that the greatest hasard fren a cow's eating an ensilage cover node of vinyl film weald bo that It would be likely to Produce an obstruction In one of the sow's two stonachs and ong Intestinal tract. Be have done sons extraction studies on the tin stabilisers, and it was found that as far aa D-22 Is con cerned, when it was Incorporated In film, none was extracted In two aoaths by water or a buffer at pH of 8.2. However, lard extracted 61 per sent of the stabiliser In seven days. POP has been shown to be extracted by fats In particular# but not by aqueous solutions. Despite these assertions# X think the best experience can be obtained by experimentation la which wo fod dogs and rats fllns eontalnlag tin stabilisers# etc. Based upon this piece of work# It would seen that these fllns are of aa extrensly low order of toxicity. If there are any further questions, do net hesitate to contact this offlee. YCry truly yours# WDICAL DIRECTOR ______ INDUSTRIAL MEDICAL AMD TOXICOLOGY MPAJtCTKkT Thus. V. Bale, M. D. at ucc 063340 ue; To (Nam*) Company Location * Copy to FOR INTERNAL CORRESPONDENCE BAKELITE COMPANY ---------------------------------------------- H33------------------------------------- 30 EAST 42nd STREET, NEW YORK 17, NEW YORK Dr. T. W. Nale 300 Madison Ave. Room 203 *><' Originating D*pt. November 30, 1953 Aruwtring Imticr data Mr. 0. G. Himmler - BB Svbimtt In considering the use of vinyl films for some agricultural applications, the toxicity of the compound will be of some importance* Though the base resins, I know, are non-toxic, I would appreciate any information you have on feeding tests on our principal plasticiser, dioctyl phthalate, and lesser plasticizers trioctyl phosphate and 2RH. Also any information available on the toxicity of lead and tin stabil izers dispersed in plasticizer or vinyl compounds will be appreciated. We are considering a grant to Rutgers University for some work on ensilage covers and one point of interest will be the toxicity to farm animals in case they should eat the plasticized sheeting. I would expect that there would be no effect because of the short residence of the compound, but it is a point which will have to be checked and any information on the ingredients will be helpful. CES:mke /ttf duff 0. E. Staff / ' RECEIVED DEC 1 1953 INDUSTRIAL JOICAL & TOXICOLOGY DEPARTMENT ucc 063341