Document JNMLyxz5dy4LwD4BVRZjjnoa2

I P 'ij--im ib i,' LIA1A206 N 3487 I n. Hjwi _________________ miahwp' t-1A 1^207 s^i^yy- ^-^^- -- ^--------------------- / DEPARTMENT or HEALTH, EDUCATION. AND WELFARE l uno*ut aarm k* aoi musnoN qohtmol rueuc mcalth scnvtca 5008 Federal Office Building Cincinnati, Ohio 45202 March 15. <9(7 l I Mr. Don 6. Fowler Lead Industrial, Aitoc., 292 Madlion Avanga Naw York, Ntw York 10017 Inc. Daar Mr. Fowlers Thank you for your coaaants on ny previous effort at gancratlng alnutat of our first mating. I have consldarad thasa, and hava produced ravlsad alnutas which ara enclosed. I trust thasa ara an laprovaaant. Most of the coaaents ware sant to all the aaabars by tholr authors. However, two, those of Drs. Landau and Eckardt nut. Uf!tt of those ara tharafora enclosed whore appropriate. Ve should now hava a second meting for further discussion. Several agenda Iteas ara apparent . .i your previous letters. If you hava thought of new ones In the aeentlm please lot aa know. I would prefer having our next aeetlng the weak of April 17 or April 24 In Washington. Could you please let aa know whether or not this would be suitable for you. If so what day and tlaes you would prefer. We will aeet In or near Dr. Bloaqulst's office unless there Is soae 'objact Ion. Due to ay expected absence froa the country for two weeks beginning March 28, could you please reply to this letter as quickly as possible so that I can coapleta artangarents before ay deperture. S Ineereli Enclosure* Aobart'J. M. Horton, M.D. Health Effect* Aasaarch Frogrea * P WM9" 'fJUSPJ aynjffyy.'i eenafgay ad^iiiieif.jwuhh i n,m N 3487.01 I fm " ' HI' 'I ll w f...... Imm MUII' I W ^ I |( || |||||<II p y -- . - m in I *rig" ..,,/ewis LIA14210 s i/ l : RJBOOMOCT CH BOHVmiABCI OP PCFULATIOB UAD UTILS CP BCE LEAD UAISCH COMCTTO juhcbal corns res in tolwtzck ooraot i . pmszD KimwTs - iV march 196T ( Meetlngi Aawr 12, i$6j, *ocm 6068, Bealth, Blueafcioei and Welfare South Bull4in*. It30-4i30 TM, freeset i Hr. T. J. Caatroo Or* L X. lekirlt Mr* S 0*' fowler Br. R. J. K. Barton, Cbiinu Ur. X. landmi (for Hr. X, toftfit) . tr. J. X. Ludvig At Its seating on IT ISorator, 1966 the Lead Liaison Ooaadttee fait that mm fora of surveillance of the lead burden of the general population aboulfl bo Instituted. The desirability cf r?=* c.ch procedure ni also referred to at the Deceuber 19&5 Lead ty^poelns and at the Senate Bearing* the following spring* It bed been hoped that this could sanehor bo Incorporated Into the health examination portion of the Rational Health Surrey. The pattern of operation of this sunrrr aak.es thle lapoeelble. Accordingly, the H--111 n fait that aone etudy method similar to that eaplcgred la the Three City Study should be developed, and carried out at suitable Intervale. This ftibccmmlttea was forned to undertaka tba dovalopacnt aad exeoutloo of each a study. This first nesting of the Subr realties was held to ooosldsr exactly what type of study would be desirable, aad at what intervals. The erlts of additional studies of the type conducted la I96I-I96? and reported as the Three City Study were discussed. Although It vas indicated that the conclusions drawn fron the Three City Study night not change greatly In a similar study conducted tlx years later, It : sms generally leaned worthwhile to consider establishing this fact . due to current Interest In the problem of lead In the acvlrotment. The following conclusions were reached. They are to be discussed by each meAer with his colleagues aad then reconsidered at a subsequent 3u The general pattern of tha Three City Study of using selected . population groups for biological Measurenante and selected urban and suburban sites for Sir Measursnsnts of lead asms useful. H i n n uni i i f m I i u inm fr N 3487.02 r I i mm mmmmm m LIA14211 -MaartaaOc unihMWIanl* ei . vMt tr fi*i --manly Ilr I faltVi ft. Tbe first study should be don* Is 19^7-1960- future Inter val* of reetudy ahould b* determined after analysis of tboaa flat*. 3. Tha original thraa cltlaa (Cincinnati, toe Angela* and Philadelphia) ahould ha ractudled and alao Chicago, hv Twk and Vaahlngton. 4. Six to eight aeroaetrle altaa ahould b* u**d In each eltor. In tha three cltlea previously dona, thraa or four of the ` original altea ahould ha retained, Especially In Xoa Angelas ' end Cincinnati acre contrast In air lead larval* ahould ha aought, aince tha vlda range of the Philadelphia aflat la tha laat study vaa advaatagaoua. It la not n*c*sa*x7 to stay vlthln the city Halts. A vlda range of air lead level* 1* of aora interest than tha political boundaries. 3. Air lead neaauraateota could ha pooled for analysis to a consid erable extent ao that laboratory vork could ha reduoed. She dally saapxea fur aU.tic.2 1c r-*-rth>y. Study of particle alae distribution of lead at each rtatloe during each aaaaon vould he a desirable addition to the earn- netrlca. Continuous analysis of particle site over long periods vould not he desirable. 6. Vo change In laboratory nethoda far air or biologic --pis* la advocated. Blood saeplea only should he obtained on people. Urine lead levels are of less valaa and add llttla or nothing to the lnfarnatlon obtained. 7* The use of selected population groups should ha continued. fever, sort unlfara groups vould he advantageous. Urban police ahould be studied In each city as before, this vlll allov far cceparlaon between tbe three City Study and future studies. It la not clear to vhat extent police can he compared between cities. More lnfarnatlon on tha nature of their vork - partic ularly the proportion of tine on foot and la vehicles - vould ha desirable. ft. Other group* previously used ahould not ha repeated. In select ing new group* enpbasla ahould b* placed on slallarlty froa place to place and fron tin* to tin* so that future rtudla* can nalntaln comparability vlthout resorting to keeping track of Individual persons. Also desirable la a llaltatlon to pfla who live and work la the aaae area. Suggested useful group* era (l) poataan fron local poet office* do** to tha aaronetrle station*. (2) housewives obtained throigh fSA or eturch groups, and \3; telephone operators fron local exchange*. Children ahould not he wed. I pnwPiiiFffiwwBwi ii jiiim.ppp^>ipiwpi>i..wwwpi" iwwpipi' """ . u1 LlAl42j2 I ( > *- .......... * 9. Tha ruaber of Individual* required In each croup should be deterainel by enalyaia of varionoe ppHad to axlatli* data, especially tie Bn-** City Study ataxlal, 10. There vi bo acrawaant on vbether the study ahould b don* by several grtxip# coordinating, aa before, or by ooe contractor. Further eontldaratlooa on thl* point are daairebla. The need for quality control of aa^-la analysis ua* atreaaad. Exper ience during the three City Study shoes thl* to be Very iapor* bant in obtaining co^arabla reeulta, not only la the projected body, but for cceparlsoo with the Three CiV Btedy i*lch bed good quality oontrol. (. ^ '*4 J '. i J' J \ m i tte1 -in (ii.i< ri i LIA 14208 iawHi r,m* irtftV -- - - --^ritrrifTrv ESSO RESEARCH AND ENGINEERING COMPANY MEDICAL RESEARCH PIVttlOM r. o. SOX at, LXXDSX, K J. OY0M ,X' Fabrusry IX, 1967 &r. hobert J. Borton Public Health fcarvlc* Dept. of Her 1th, Education, End Valfara national Canter for Sir Foliation Control Washington, D. C. Soar Dr. Bortoeu to far X have recalvad tha following cooaant* concerning tha proposed a tody which will rapraEant surveillance of population load level*i '*1, That provision* Vo nada tor 1dyertifatIon and davalopnant of da tallad inforaatian In tho caaaa of individuals fco have appreciably higher load veluaa than thoaa found la tha ganaral population study. 1. Shat consideration he given to adding one notably industrialised city an tha otudy, aoch no Detroit. "J. That while tha eoncept of pooling lead naaaureoenta night facilitate otudlaa, proviaIona for thorough appreciation of fluctuation rangaa ha aaaured. 9ut while tha adequacy of blood sasplas aIona la appraciatad, thought night be given to collection of urine apaelaena on a snail fraction of those studied unless it la felt that correlations or lack thereof have bean so adequately doctaanted that tha absence of urine studies could not st ill be criticised. "5. That school teachers and flraatn night ha considered as useful groups for study together with poataen. *i. Vhlla it la stated that the pattern of operation of tha Batlonal Bealth Survey Dikes Incorporation of tka proposad study with it inpoaalbla, it still night be useful to ask that this Survey obtain and eubnit apaelaena ` for lead studies to suppleawnt the studies proposed. 7. If sew people or group* ar* aalected for study, sons of thata should b# conparabls to group* la prtvloua study aa to Exposure, age, ate." As 1 receive additional coeoent* Iron nanbars of tha Cooalttee X shall be happy to transalt then to you. Most of tha above coaeant* I believe war* already discussed at our last nesting, but X aa alsply sanding than on to you for your lnforaatlon. linearely yours, i K-ttcL+&- BXXthsa ccj Dr. J. 6. Ksllar X. X. XCXAJU7T, KD Director hi .. Min.jKwiwi "i i.s'sn i nia.is.s .-i. ji -iw1 m k4 \ N 3487.03 I mmm. i V I PPWPiMPPP^ *. 1*~-^ --- ^ V. !*-*/ tlAlM .K. **.SAiblt Memorandum . WPliiil'j-J-JJ1 LIA14209 <L. - i tMiiii itha Vfr* a* * *. i Uf lit U l, bJwgn Oi *U\kJ Mt#A . A fUBUC HEALTH (XftVlC* TO Dr. Eobert J. H. Morton ' Health Ultcti butrch Frogrem, RCAFC DATt: February 13, 1JA7 ntou i Statistical Advisor, National Center for Air Pollution Control su^ccrI lipert of th* KHtlA| of thm Subcooolttoo oo Sumilltoct of VopoUtioo L**4 Unit k t ! t i I I. nil Mao will npplMtnt And comment on John Udvl('i mmo of February 7 In Addition to your lunMry of tin Mating. 2. Though 1 probably contrlbutad llttla to tho dtacuaaloo, 1 ana proaant At tha aaatlng. I balieva Id Blemqulst mas out of toon At tba tlM . of tha Mating and tbarafora could not have Attendad. 3. t suggest you el'talnate Itea 2 of your uMry. 4. I disagree with John that tha question of using children In tha pro* posed resurvey was not discussed, While be. hacWenaie'e comments My be valid, 1 believe that community surveys of this type should be United In about tha fashion stated In ltea 1, I fall to understand what John has In nlnd when ha says, "consideration of children to som degree at least" In the next to the lest paragraph of page 2. 3. I slallarly fall to understand the remainder of this mm paragraph (next to last paragraph of page 2.) .: -- 1 4 While 1 have oo Immediate solution to the problem of the variability of Maturement of lead In the ambient atmosphere, l wonder If the resolution of this problem Is essential to the determination of the desirability of a resurvey. In my opinion, the critical measurements are those of lead levels In the blood. If these measurement errors ` are small enough, one might conduct a survey even In the complete absence of atmospheric lead Mesureneats. Emanuel Landau, Ih. D. aidUuMSMetnaA^MMuMmiaMilhh ii ^mis ttiMi Jirawx WSTI Wlt coir upvcno* mooum 1TL5VW "WPPItpi "H1 SM USW .pm ujv4p m N 3487.04 Is-'.