Document JNKwVRpKKjy5yeraqkDbGQ226

ABD00062605 TABLE 8-1 Cancer Data Sheet for derivation of q-j* Compound: Chloroethene Reference: Maltont et al., 1980, 1981 Species, Strain, Sex: Rat, Sprague-Dawley, M,F combined Body weight: 0.35 kg (assumed) Length of exposure (1e) * 365 days Length of experiment (Le) * up to 1029 days Lifespan of animal (L) - 1029 days Tumor site and type: Liver angiosarcoma Route, vehicle: Inhalation, air v :/ -N Experimental Ooses or Exposures p-'/ enr mg/m* t / S' Sr/s / 10 Qr/5" 25.6 25 13TI5 63.9 50 &r\ 100 6X2 150 QtZ 127.8 255.6 383.4 200 511.2 250 639.0 500 1278.1 2500 6390.5 6000 15337.4 10,000 25562.3 30,000 76687.1 Controls Transformed 0osea (mg/kg/day) 0.344 0.860 1.719 3.438 5.158 6.878 8.596 17.19 86.97 206.3 343.9 1031.6 0.0 Incidence No. Responding/No. Tested or Examined 1/119 5/120 1/60 1/120 6/119 12/120 3/59 6/60 13/60 13/59 7/60 18/60 0/363 ,0 ft .0 .o . 01 * .0^ .O2 .3 ,Q? Unadjusted qi* from study - 5.0381387x10"* (mg/kg/day)"xb Human qj* - 2.95x10"* (mg/kg/day)'1 ^ r" a0*0.223 mVday x 4/24 x 5/7 x (C]x0.5+0.35 x 365/1029 bThe unadjusted qi* was derived from the dose-response data up to doses of 1.719 mg/kg/day. The goodness of fit hypothesis was rejected for the data at >3.438 mg/kg/day. 0707p -87- t: * t /a v*i. f 09/17/85 ABD00062606 TABLE 8-1 Cancer Data Sheet for Derivation of Compound: Chloroethene Reference: Haltonl et al., 1980, 1981 Species, Strain, Sex: Rat, Sprague-Oawley, H.F combined Body weight: 0.35 kg (assumed) Length of exposure (le) - 365 days Length of experiment (Le) up to 1029 days Lifespan of animal (L) - 1029 days Tumor site and type: liver angiosarcoma Route, vehicle: Inhalation, air \ A Experimental Doses or Exposures x ppm, mg/m* T &r/s 10 r/r 25 &rtf 50 J3r 100 I3T2 150 6fZ 200 250 500 2500 6000 10,000 30,000 25.6 63.9 127.8 255.6 383.4 511.2 639.0 1278.1 6390.5 15337.4 25562.3 76687.1 Controls Transformed 0osea (mg/kg/day) 0.344 0.860 1.719 57*38 5.158 6.878 8.596 17.19 86.97 206.3 343.9 1031.6 0.0 Incidence No. Responding/No. Tested or Examined 1/119 5/120 1/60 1/120 6/119 12/120 3/59 6/60 13/60 13/59 7/60 18/60 0/363 . 3 X. .0 ' .o : * .oi r* ,0^ * .Ol-' .J v Unadjusted qt* from study 5.0381387x10"* (mg/kg/day)"ll> Human qj* 2.95X10*1 (mg/kg/day)-1 ^ '/'* ' r" aD0.223 m/day x 4/24 x 5/7 x [C]x0.5*0.35 x 365/1029 bThe unadjusted q^* was derived from the dose-response data up to doses of 1.719 mg/kg/day. The goodness of fit hypothesis was rejected for the data at >3.438 mg/kg/day. i. 0707p -87- f' 09/17/85