Document JJ6bODrkDzb660Kx0mrLao14a

Industrial Hygiene Digest - 25 January, 1950 78 Experimental Intoxication vith Selenium* C.A. Vesce. ____Folia Med. 31, p.. 415 (194a) Italian. / j' ; Hie halldea, oxldea and aclda of aelenlum are particularly dangerous to man, either by inhalation of dust and vapora or by cutaneous aboorption. In Industrial cases poisoning Is generally acute, vhereaa In endemic areas ' the effects are gradual. Irritation of the skin and mucosae, loss of the sense of smell, and Irritation of the respiratory and alimentary tract have frequently been observed. Physical injury Is generalized. Degenerative 'changes are recorded In the liver and kidney, and In the reticulo-endothelial . -.system of the spleen hypertrophic changes have been observed. Experiments on guinea pigs and dogs Bhoved similar changes and confirmed the results of sin earlier experimenter. -- Condensed from Brit. J. Ind. Med. 79 Studies In Detoxication, 21, The Fates of Qulnoland Resorcinol In the Rabbit in relation to the Metabolism of Benzene. (SLA. Gfartan and R.T. Williams. Biochem. J. |4, 234-230 (1949)'. This study vaa undertaken to elucidate certain aspects of the metabo lism of benzene and phenol. There is little exact information concerning the fate of these tvo phenols In the body. Qulnol is of Importance in Industry as a photographic chemical and as a food preservative. Qulnol and - resorcinol are excreted almost entirely conjugated; but appreciable amounts of the Oatter are excreted In' the free state, Qulnol is excreted almost entirely as monoglucuronide (43 per cent) and manoaulpbate (30 per cent), only traces are In the free state. Resorcinol is excreted as monoglucuron- lde (32 per cent), monosulphate (13*5 per cent) and In the free state (11*4 per cent). Neither-qulnol nor reeorcln&l is oxidized In vivo to trihydric phenols or other substances, The results are discussed In relation to the metabolism of benzene; phenol and catechol. -- Bull. Hyg. 80 Studies In Detoxication. 19. The Metabolism of Benzene. 1. (a) The Deter mination of Phenol In PnSe'viih g;6-Dlchloroquinone-chlorolmide. (b) tche Excretion of Phenol, Glucuronic Acid and Ethereal Sulfate by Babbits receiving Benzene and Phenol, (c) Observations on the Determination of Catechol, Qulnol, and Mucanlo Acid In Urine. J,W, Parteous and R.T. 'Williams. Biochem. J. 44, 46-5$ (1949). Hiis Investigation vaa undertaken to determine .the amount of phenol and other metabolites excreted by rabbits receiving benzene orally, and a quantitative study vas made of the excretion of phenol, glucuronic acid and ethereal sulfhtfe*-. A nev method 66r determining phenol In urine In the presence of catechol and qulnol vas developed; this is based on stSum distillation of phenol and the use of the blue colour 'Indicator 2:6 - dlbhloroqulnonechlarolmlde. The methods are described. ' The results shov that about 21 per cent of the benzene, given orally Is excreted as phenols, 9*2 per cent, as phenol and. 11*5 per cent, as other phenols, that is total conjugates; r^x5 per cent.of the benzene la excreted as ethereal sulfates, end 11*2 per cent, as glucuronldes. Only traces of free phenol are ex creted. .Attempts to estimate catechol awA qulnol In the urine vere not successful. --Bull. Hyg.