Document JGrpVnnKDDNVbZpRB9yGx606

FILE NAME: DuPont (DUP) DATE: 1964 Nov 9 DOC#: DUP027 DOCUMENT DESCRIPTION: Memo RE Asbestosis with Attached Conference Proceedings on Asbestos from G.J. Stopps - Sent to All Plant Physicians EMPLOYEE RELATIONS DEPARTMENT MEDICAL DIVISION WILMINGTON, DELAWARE November 9, 1964 TO: ALL PLANT PHYSICIANS FRf&: C. A. D'AL0N20, M. D F \ue. : C *O0 7 SUBJECT: ASBESTOS IS The attached summary of a Conference on Asbestosis is a "Trip Report" to us by Dr. G. J. Stopps, of our Haskell Laboratory. It is such a timely and interesting report that we are sending a copy to each of our Plant Physicians. Please note particularly the last paragraph of page 6. If any of you feel that there is any particular question in this regard, we would be pleased to hear from you. ' CD'A/smr Enel. \ \ ! f\ V \ OV 111954 HASKELL LABORATORY k ll2> This is MEMORANDUM TO: J. A. Zapp, J r ^ TOOK: G. J. S t o p p s ^ / Exhibit t-io. .!... November .2, 1964 , / c..... . /' / --T" V"-- / 9T ' . OT ..y) f ! ........b"'" v ..;.. ; ; _ LV, ... in i?; TRIP REPORT Sp-0:0ic-i l/zrr.'.r.zr tv: Conference on Biological Effects oi AsDastOS^ c> held Monday, Tuesday and Wednesday, October _19> 20-.and 21, -1-964 under the auspices of the New York Acacemy of Soi^nce^ the Section of Biological and Medical Sciences ~ L'z'^o'jizh this was a well-conducted and well-attendee meeting t*-'*"heing&so:7ie"three to four hundred persons present at almost eve-v ssson, there was also a feeling that there were several zhoszs oresent at the banquet of information presented. No ccuot c ^--vrg larcelv stemmed from the fact that out c_ some 5P ~ve-,~oniv"two of them were given by people connected with t'Vasbestos industry in the United States and Canada, wnereas ^ th*"e we~e seven given by representatives of the asDes.cs ncus-.j' i ^ ^ t a ^ n and a further three or four papers were given by persons connected with the asbestos industry in South Africa. the rcint of view of the Du Pont Company as a w*ncj.e,^t*.e r.se- ~--eWs*t of"the meetings was in drawing attention to the fact that asbestesis and complications of asbestesis have now Deen ^ ^ found in persons who would not in the ordinary way come to m_.na <=.s being exoosed to asbestos; that is to say, they ao not work in asbestos*mines, asbestos mills, or asbestos textile .actor es. Underlining this relatively wide exposure of persons co^asoestos was the work of I. J. Selikoff, from the Kt.^ Sinai Hosp^a., New York, who has been studying the workers in tne insu_at_on trades -n vav;Yc-^k City. The investigation reported concerned 15^2 memoers ofthe'International Association of Heat and Frost Insulators ana Asbestos Workers in the New York-New Jersey metropolitan area^ - study included every individual who was a memoer of tnaS^un.on December 31, 19*2, or who Joined by Deeemser 31, M sixty-four tier. were dead on January 1, 1-6.,, `"" .'i -3- ' rsnn de=th was studied. One thousand two hundred -ty-e-t- * * were Still alive and 1117 of these were examined This represent 8 9 .9* of the modulation at risk. Clinical, rad-olo^cal a.n- ,, pulmonary function examinations were also mace cu these me..^Xj-y Ean^ns of the degree of asbestesis present an four grades *a..6..i6 fr'on"oeto 3 indicated that in those having 0 to 9 years of.s*P?=^e to asbestos, 8 9 .6 had no asbestosis present, w n i l e h a d ^ g . aoe -. V,-ne^e=c w*th 40 or more years of exposure, 9-*-2 had graae c asbestosis and only 5.8? had none. In an analysis of 307 consecutive i? 3 ? 2> 2 d^ths'a.ons asbestos insulatio^workers, 55 - r e w o u n d to have carcinomas of the lunbJ y ,. ,, a-,-.,*. and 27 had neoplasms au ^ ^ ^ ^ 1 7 * ^ i S 0 d e^ e s ^ s O I St af o W . * * conclusion of this paoer was that. pulmo^ar} asoe A a?srl?i =- t ris-, of insulation orders in^the dnitecj.^es,^.,. it will be noted from upon the point oeve.oped later^j Hospital that this risk of ^ f-kerTat the Kt. Sinai ;t-e,, Q-? .^g resoiratcry "ao`peas t'o be significantly the^ir.sulation workers than amongst the generau population. . r At a later sessien a. C. o ^ v h - t'^e y . z . Sinai Hospital t- a of carclnonat garsoounpssfturttneherinsulation w o o e r s . _ fF,--t-." of" o; all he noted that thli in r.; fc- - :he :i;:-;tiCn workers carried out over tne years l"ir* v .-.fco- Cf deaths were increased (ocser.-a- 2 ^ f ' ir s,* -n _ - t ^ - hthss coaauu_ss._e_,,ed_P_boCy-yn accaandnn.cceecrroeloonf xl(~uno>nonbgsserarvnve~aecc.pDr*ya,url.exlp(pPeoeCc-c*ts-etse--.v1eu0u); , __ expected i). c-.n- s-o..i-w.. a ^ n Ciude a total c: P v=-.-- -.r then undated nis inc...ia-v --- 7 ici", to Auras ^ H*- cc^e-utive deaths from. January 1 , " h 'S~SeTiC.-. i:*;:!::. n--s statistics did not mat e r i a l f e - ;nT c. iB.Vlne the fact that deat.ns aue to in^s- out oia serve wO u^a---- .1er-ta.*iv Jnc-eased over w.nat mign- sbdor-inal necplas-.s were als. -ej^y -fltf* rzl oooulatior. have been expected if tne ae.:h_ta.e;__;- - e - va_laty of hsd prevailed. B r o f "iastrointestihal tract . reasons the accuracy c. Cii^ u!"s * 0<r the c such deatns. -p -- -Iic-S ' after, insecure, an w. - . -- -7-- -vnshTe data s.ncwea ^ne c.ctnv.-. uC analyses o- a--. * ^ ""esngC<sviy true of stomach cancer presumptive only. i-is v,c"' es^ec----J fg 0f 7). Therefore "8 out'of 13) and Se.neralizeo a b o o r-.^-^ -- evea aop, it is possible "recorded. In addition to the common tnan whe ^ 0. ' ,h tr.e~p w^e three men alive neoplasia honest the i p i e ^ a l , and 1 peritoneal with known ne^ylasm. ( 1 lung -a . a 0f tongue cancer, mesothelioma) . as well as one appcie.-.^ s'-^cess^u1 resectic one c: OCt\ ized lung cancer fc s paper, D r . Harr had presumably not this survey. 1r. questions C, Lk cut that. the crou of of workers _:ical point Oof Vvie.w . ^ on cf--he results --r industry since -r .he F ^ l - c that the there had not been any particular cause for i i6ence of asbestos insulation workers were showing a.. ^nc....ai an. neoplasia 3S 4 - 3- A report from Turner Brothers Asbestos Co^any^Ltd., & Rochdale, England, and presen e y su^ta^le dust prevention somewhat more op^nust-c^ enfoorrcceedd iinn tthhee aassbbeessttooss iinnddustry. regulations were .nuroGuceQauu - - - aBbest0s f-actory carri*ed~ out In a mortality stucj Asbestos Industry Regula Prior to the enforcement of the ek*loyed for 20 years and tions excess rnor*al-ti *r ^ association with asbestcsis uowards was obser\e-. Lung,,e_9 M * -nrooortion of this excess. A was responsible for a considerableproport n j 1 e3CD0Sed since study of a group o f s h o w s ^ a reduction in mortality the regulations went in.o e*^ec. ehov-s a re hd inte - rate without an.efx^cSe^ssexCti-elmuengracraintcye**f pleural mesothelioma i th in tnat whe extreme of even a very ffew ccaasseess in a in ind-Istry hilhly significant. Ireland, tackled the problem of r. C. Elmes of Belfast, >f view. He had studied ^2 cases mesothelioma from another point , __^r,,nn in his department in Belfast over r i * being about thr.e-5uart.rs /positive history of exposure to asbestos at of a million peop.lei,n 32h of the cases cormmpaarreedd wwiitthh oonnllyy 9 f ** work was coobnttarionlsec Asbestos bodies were found in b n e i u n g - O - 6w= cf*oatie nttss'witth tmieessootthheelliioomma of t'hhe pleurraa, 20* of Pa 'ien'~ w-~ ca,r7cinoma of the bronchus and 2-5* ^'csssf Tv>e freauency of fina^ng c- =^ftos &-L,e-wv= bodies ir. mal-gnst..w Qj.s inner dy'ng of non-malignan* c^ses-e tbheetwleuenng_60s_annd.^gn6e^- ye=~~ V o went into industry between 190p -g ^ group who started work between and 1915 1915 and `'nan -n_w.r.e 192p. jsetween 1^06 ana 1 Q2~ 1W over 1000 tons a t compared year with 6of00 boiler composition " * ^ por; ^ 5-oilM coaoosition was an insulat ions a year at rttar t f ; ,,tilerablep4 po'rtlon of asbestos finer, ing material con.ainin* a consla cl-5 ^ ,a for the development o. EU..?:r^!?irrn-y0a-.er^xtSesurfmay STSp to forty 7 TM that increasing^numbers of oases'arising from exposure can be expected for many years to come. , -r f,,e v p r Pneumoconiosis Research Unj.t, Dr- WaS^;i noted that an association between Glamorgan, W e s , B--wx-.ii.sie, cenerallv accepteG. asbestos 'shown that there was an increased Kore recen. *nves.;s-;--.. n^d mesotheliomas occurring in inciaence of pleu-&1 <=-nG pe-- ., pvnosed to asbestos Gust, people occupationally or.f "h a ^ b e S e" remely slight and In some of these cases 'he features of asbestcsis. not me sounflfyicpiaetnhtnlotgoicparloduecveia.tnheo.h-osftowlOoe-sc^- l^a h . ^ presenc^e of " anlSo cafesSofrthi! tSmt? S ^ i e e n ' c o n f i n e d histologically. 4 all of these cases have been confined to one ^ area The majority of thes_ p e o p l e r stlgations have the"1"asbestos ^ u f a c t u r i n g ^ S i n i ^ ^ r t o n s are present S S S a l l y p a r t i c u l a r type of asbestos. ^ Another study taking much t h e s ^ o e vv d t lineb of Belfast ^as reported g ^ u s ^ o f *the ^ ^ Newhouse east end of Lonccn. New..o-se - J - ^ t s in whom the diagnoses c. c l o u d s j the first consisteajrf B, P*--..* biopsy. In all. S U n - h ^ o m a . had been confirmee Histories were octaane but seven the past occupational anc ^ 0 J l L n anfi in 62 it was -1*- p*.atiemTinh.te.s etoah-reTliPteiustmorrewcaosrad-eJad!r nddeeaae^^-iah^w.w&a~u5 1917 ~ 'DUt ^ cfor*t--yh*0ete-fTne^mraoralf?leesttshnee sirles died before 1 9on <e~ under the age o >5. and development of te.^nal between the first expesu-e c ,,-.--e- between 16 ana pp 3 of 76 patients at toe the near. 57* _j_-- i 4-cv'eQ y sex anncd da of birth with those tr*ced_ mesotheliom C.-. ==~m'*e"-"w,ncosfp**.dir-s--j_se^rc*ies--; *p*\ 52 wW'll.6 of the contro- ceen ex.posed to asbestos as cg*g"teeosnized; work in Three main types cf ex.o^.e - - ,;tirlg Biterials ^ o.he- ____ o z ascestos t-ex*-- , - ?tors ana exposure ww a--- products, asbestos. EiE-hteeno. t..cse brought hor.e cy ! -elatives were worx.ne wj-n e-- n cved in factory WuPr. o. v>n-=- i^.. T-r.s factory openea ... u n h ! ? y e i n Cr h ; H "uier_orcrooldollte.&^ ^ o s e S ? i r t s; s s m u ^ r w t t h ^ S c U ^ V n v i of the c ^ r j ! aari.. mhe difference in the p- opo- -- ^ - statistically rnifican the two series was X)- Tar. Webster, of the F-;e' ^ c;;:w7 ^ V / t Sparer that althougn Johannesburg, South A f r i c a g r o w t h of_a -^-a^ experiments have B.c.-eucu ^ ascestos was neiotheliSma-like tumor in f *had not been possible to Inoculated directly the animal to ar. ascestos c... ^reduce carcinomata by expo-- b * cloud. ' ,, a,,tnnV ,, ^ euri mescthelial tumors from ; A further stuay o yieu. a_ ...c M v e ~n0ol> Engl ana. Seven records was given by V. ex a r ^ e s ofdiffuse mesotheliomas, teen cases were selec.ea as^ cne'was peritoneal. Eviaence 01 Sixteen cf these were FlJ?r.u no ^ (82i)P of the 17 mesotne-- o.... asbestos exposure was ob...ne- -- - ^ * i r  - 5- cases. Hon^ ^ at|ihaierhanaied asbestos^Of1those giving an pe--mp-oovyfeida. tcv firms of.insulatpiaotnients5 were employedj vbyv sRa?ceKkwwaa.ree capers (sh.pbu-ldlng), P sacV;s Khlch had containeo asbe stos Only' two of the 11; patioot.> had worked ^ n^ ^ tl ^ ^ ^ t S n ^ r ^ o r o t . oufootu^. using asbestos cemenu. .. "Buchanan, Ministry of Labour, London, pointed Dr. William Dstudies of the Eritish Viual S^awis^cs reco. -- out that earlier studies O - C ^ e e i f t h ^ presence of indicated an apparent, sscd8wd thoracic tumor; although such an asbestcsis s S - vears^efire 1947, it was studies. UP to the ena of ^ , 5 8 , ^ a n n u a l totals of the_ Presence ct as oes.o s ^ . 'blnCreasing. The proportion also sucn cert-iicaves we.e cure. poth sexes continen to recording a thoracic tumor has also in oo.n^s^ ^ ^ currently increase disproportionately p.bestcsis present have also a over 5 0 yc of the ma-es ayj.n& I s t e s - d * "'y rising incidence neoplasm. Even when viewed agains. .he s.ead y ^ m t or. w cf lung cancer in.tne population as; ^ - * . ^ - reai one. there was little aoutt thau un^s *nc.ee Dr. Bader presented an interesting series ^ f ne s[g0 emoloyees actively working in an weT,e effipi0ved discontinued at* which time the plant foil owed sync's that time with serial operation. The men have ^een f function investigations, clinical, radiological and ?uncu 0n examinations, when Bering the baa.lin. .taU.., = t i o , ^ ,, o l capillary abnormal, revealed the c^ s i c -ind- g volumes, well-preservea block syndrome un;xorm aerease 1 J saturation --- maximum b r e a k i n g cPaCt ^ eJco, values, and decreased (especially on exercise), normal pCOa at rest and exercise occurred Effusing capacity. Hyperventila^io.. soace ventilation and ^ -n more than half the cases, ana aea The most sensitive index of alveolar ventilation were increased, saturation. Slight reduc^c.; iioaired function was arterial oxygen below 92^ was at rest was `found in six, and reduction b e i ^ * ^ o? the workmen on exercise P ^ ^ ^ ^ l S p m l n t or worsening were made in terms of x-r*y P^og. ei measurements of pulmonary func- of dyspnea on exertion and further m complications of the tlon. Follow-up observations l i l t e d by 6 men disease being studied. Of the 17 ^ a i m e s o t h e l l o m a , of are now dead; 2 of lung, b n m ona-y asbestosis (core pulmonale), gastric carcinoma, and 2 of pulmonary as ' . . - 6- lfL1\ <n* TM . n 0n Nine of ?Lv^1ne-?lll^ng^'resection the original of a lung or workmen are lung cancer. Two Pape- -re Preserved Py wo^ej^^-^Britaln^diacusalng the value of routine Ross Hunt, of Erj.t_wh r>e-.v_ g Asv,""t`os, Ltd., Yorkshire, iunc function stud.es on 8.^, England, gave the=;?'iirS fictory. Routine work in th.s e-rPovees in an asoesucs o^oces.-ng, 1060 *r an asoestos t u i i li lung function was etartea ;a ~ s te create a textile plant in tne nor.n values, gas transfer set of normal fi b r e s for *g ventilation on exercise, factor coefficients, *" "we 7v <*cts used in these tests and forced breathing c a p a c ^ e . . - -. - and stature groups were volunteers c* bo^n sexe. -.n 'v_- *c,n. asbestos. Tnese . from departments other than tno-e - ^ - - - the regression formulae -- =u*ts were then analysea s ^ u i s ^ c a - , w o r k i n g in those *T" 7 ^ j *-- t^e results c- n=.: t** ' *.c.c w*"- also ,,,.~s-j~ns exposed to ashes os. r"T1i*-."T"--- *-- from taking used"as"a" screen to prevent people^w-- ; triValent. Some uo Vi1orr. -->- up*--wsc---'-T.ents wnere tses^- up.r-j--h-n-: :DOv.i -<-.i c----,*ct- , cJfficulties wcr= e..ww-- e-;1-4 * w-re overcome ..a --- sarnt-mr '-,p^'orn"n-i=c'ue. -- . hnicue and results o: taper dea.s ;he main with the ht.. prpp r)c^J'Jn*-s, l/O ^ ever *ne ?- : . r : i ! ^ ~ a o d `vital capacity before any pe"',ease in gs.s u. a.^-c. c^-1" wlwfe or"clinical signs are evident. Thomson an; w j. Smither, .?i.,,w.--... The other paper given by_*. t i ^ V ^ ^ K e d i i i n e and from Cape _ the London School of r ^ e n e - - London. England, indicated Insulation and A s t e s t e s ^ r . - v were the best L s U m l n S s ^ U l i s t ^ i r L o n ^ t tie nfany pulmonary function ^ 7 / : ^ * ? P * ~ f r ^ t h e c o n o e n . at ui'is~sPT 4 h h f i i n i ~ as^es -----s, s greater -_hy.aa.ri. y>s-es o-^-i`cfe1-n4ally* ...Sn is occupati,on *,----- ^-s..-, -s t -.v,pr.e not only tne pe-s^n . ^ h .-.e be borne in mine *;;;:?: g do-it-yourself worker =-ic^ -Js hobbies - c. j.-- w=..*ce , home insui&^c^. na^c"Jal exocsure to asoes uos a-. is extreme.y ?Sicw---^r".,CLccree ^tw-.he*ee ppTy r-. ocgit >nnoo_si_eiss 0.fcoj..rrow&awWdcepi6VaKsSgnotsoedoinJeLpleyvuee&r--a^i, -*, - w i- s important. th. . * .,p6-re- n--00 as poor, varying from a ^ev. v*.e exposed to asbestos vne^e. a. Kithin h ^ - ^ ^ u ; ? " n "h t i n e d in such .aterlils aL also of course \ : - 7- no* asbestos fiber penetrates through the respiratory passages d not the classification of the tan's occupation. For persons ho would like infection on this topic, he abstracts of the Conference onjh. f f that the roceedings6o f th^conference will be published within the year. t) > t* GJS/fiyb