Document J6GkK2dD9rR9Yp49mYzVpBBe

rr mM MM --M | HR RA6_ 3222 404 TRADE SECRET Study Title 'H-24768: Subchronic Toxicity WithOne9Ge0n-eDraaytiGoanvaRgeeprSotduudcytiinonRaEtvsaluations Volume dof 5 Laboratory Projct ID: DuPont 5990 ARaa6 - 3422 Duron TEST GUIDELINES: U.S. EPA Health Effects Test Guidelines OPPTS 870.3100 (1998) AutHoR: Susin A MacKenzie, VM, PhD, DAB. STUDY COMPLETED ON: January 18, 2002 PERFORMING LABORATORY: E.I. duPontde Nemours and Company Haskell Laboratory for Health and Environmental Sciences Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 --w H0.-2D4a76y8:GaSvuabgcehrSotnuidcy TinoxRiactistywithOnGeeneration Reproductive Evaluations DuPon-5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IT - 0 mg/kg/day sex: Females Animal Ref Microscopic & Macroscopic Findings 646507 TKeirlmliendalonSaDcaryif: ic1e83 AEnxipmoaslureisGrsoiugnped: o3f-fMonftrhomRenceocvreorpysy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orSmPaLlEiEtNy, ObTsHeYrRvOeIdD G: LAND, PARATHYROID GLANDS Histopathology + LIVERHY: PERPLASIA, BILIARY, minimal. CauSESOAFCRIDFEIACTEH BY DESIGN No MiKcIrDNoEsYcSo,picSPLAEbEnNo,rmTaHlYiRtOyIODbGsLeArNvDed : 6a6s11 --~ TKeirlmliendalonSaDcaryi:fic1e24 EAnxipmoaslureisGrsoiugpned: o1f-fNonftrhomRenceocvreorpysy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHbEAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NA`LSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, 646511 Continued on the next page ... Se Company Sanitized. Does notcontainTSCA C81 H9-02-4D7a6y8G:avSaubgcehSrtourdiyc TinoxRiactistywithOne-Generation Reproductive Evaluations DuPont-5990 ~~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IT - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings sa6s11 Continued from previous page Gross Pathology : No MaTcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHyYROObIsDeGrLvAeNdDS:, TRACHEA, ESOPHAGUS, PGHLAARNYDNX(/FLEAMRAYLNEK),, OEVYAER(ISE)S,WITUHTEROUPST,ICUNREIRNVAER,Y FENUR/KNEE JOINT, STERNUM, NOSE BSKLIAND,DERM,AMMARY . Histopathology CAUSESOAFCRIDFEIACTEH B: Y DESIGN No MiLcIVrEoRs,copKiIcDNEAYbSn,ormSPaLlEiEtNy, ObTsHeYrRvOeIdD GLAND 646530 TKeirlmliendalonSaDcayri:fic1e83 AEnxipnoaslureisGrsoiugpned: o3f-fNonftrhomRenceocvreorpysy - Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormSPaLlEiEtNy, OTbHsYeRrOvIeDd GLAND, PARATHYROID GLANDS Histopathology causeSOAFCRIDFEIACTEH B: Y DESTGN. No MiLcIVrEoRs,copKiIDcNEAYbSn,ormSPaLlEiEtNy, ObTsHeYrRvOeIdD G:LAND --o20CompanySanitized. DoesnotcontTSaCAiCBnI H-24768: Subchroic 90-Day Gavage Study TinoxRiactistywithOne:Generation Reproducive Evaluations DuPont5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IT - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646537 KTeirlmliendalonSaDcary:ific9e6 AEnxipmoaslureisGrsoiugpned: o9f0f-DafyroEmxpnoescurroepsy Gross pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHbEAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICWANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARROYINDX/LGALARNYDN,X, `EPVAREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y FGELMAUNRD/K(NFEEEMAJLOEI)NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology : THYROAILDTEGRLAATNIDON:, COLLOID, minimal. - ureRUSDIL:ATATION, LUMEN, mild. CAUSESOAFCRDIEFAITCHE B Y DESIGN. No MiLcIVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, 646537 Continued on the next page --.. - `CompanySanitized. Doesnot containTSCACBI 012-4D7a6y8:GavSaubgeehSrtoundiycTionxRiactistywith One-Generation Reproductive Evaluations DuPon59%0 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IT - 0 mg/kg/day Sex: Females Aniral Ret Microscopic & Macroscopic Findings 546537 Continued from previous page Histopathology : No MiPcArRoAsTcHoYpRiOcIDAbGLnAoNrDmSa,liTtRyACOHbEsAe,rveEdSOP:HAGUS, PHARYNK/LARYNK, OEVVAER(TSE)S,WIUTRHINOAPRTYICSNLEARDVDEE,R, SKFIENW,JRM/AKMNMEAERJYOIGNLTA,NDST(EFRENNOANL,E),BONE . MARROW, `NOSE T & IZ, NOSE III & IV Ga6s38 TKeirlmliendalonsaDcaryi:fic9e AEnxipmoaslureisGrsoiugpned: Sof0f-DafyromExnpeocsruorepsy Gross Patholosy No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSK:ELETAL MUSCLE, SPLEEN, RIOUKETUAM,, BPRAANICNR,EASS,PINCBACLUNCM,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMW,ZH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVTEG,ULAPRITLUYIWTPAHRYNOGDLEA,ND,THYMUS, --~ TPHHYARRYONIED/LGALRAYNND,K, PSAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y FGLEAMNUDR/K(NFEEEMALJEO)I.NT,OVASRTIEERSN,OM,UTENROUSSE, URINARY BLADDER, Histopathology causeSoAFCRpIFeIaCtE B: Y DESIGN. 546538 Continued on the next page -. on Compny Sanitized. Does notcontain TSCA CBI HL24768: Subehronic Toxicity 90.Day Gavage Study in Rats with One.Generation Reproductive Evaluations DuPon-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ret Microscopic & Macroscopic Findings 646538 Continued from previous page Histopathology No MiLIcVrEoRs,copKiIDcNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,veSdKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUENN,TERJEIJCUNLUYMM,PH ANODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIXD/LGALRAYNNDK,, `BPYAER(ATSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y FGLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTEBROUNSE, MAURRRIONWA,RYNOBSLAEDDIER&, II, NOSE raw 646549 TKeirlmliendalonsaDcary:ific1e24 EAnxipmoaslureisGrsoiugpned: o1f-fMonftrhomReneccorvoeprsyy Gross Pathology : -- No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,vedSKELETAL MUSCLE, SPLEEN, ATOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIXD/LGALRAYNID,K, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,IM,UTENROUSSE, URINARY BLADDER, 646549 Continued on the next page -... Tons Company Sanitized. Does not contain TSCA CBI 9H-02-4D7a6y8:GavSaubgcehSrtoundiyc TionxRiactistywithOneGeneration Reproductive Evaluations DuPont:5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646549 Continued from previous page Histopathology KIDNEY`NSEP:HROPATHY, CHRONIC PROGRESSIVE, minimal CAUSESOAFCRDIEFAITCHE B: Y DESIGN. No MiLcIrVEoRs,copSiPcLEEANb,noTrHmYaRlOiItDy GObLsAeNrDved : 6a6551 TKeirlmliendalonsaDacyri:fic1e24 EAnxipmoaslureisGrsoiugpned: o1f-fNonftrhomRneeccorvoeprysy Gross Pathology : KIDNEYCYSST, CLEAR, LEFT, 3t DIA -- No MaLIcVrEoRs,copLUiNcGSA,bnoHrEAmRaTl,itySKEOLbEsTeArLveMdUS:CLE, SPLEEN, AORTA, BRAIN, CSEPCIUNMA,L CCOORLDO,N, SRTEOCMTAUCMH,, MDUEOSDEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPVAANCRRYEAS, GSLCAINADTSI,C NMEARNVDEI,BULPAIRTUILTYAMRPYH GNLOADNE,D, TTHHYMYURSO,IDADGLRAENNDA.L GLANDS, EPYAER(AST)HYWRIOTIHD OGLPATNIDCS,NERTVREA,CHESAK,IN.ESOMPAHMAMGAURSY, GLPAHNADRYN(XF/ELMAARLYEN),K, OSVTAERRINEUSM,, NUTOESREUS, URINARY BLADDER, FENUR/KNEE JOINT, 646551 Continued on the next page EE Company Sanitized. Does not contain TSCA CBI H902-4D7a6y8:GavSaubgeehSrtoundiyc TinoxRiactistywith One Generation Reproductive Evaluations DuPont 5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IT - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646551 Continued from previous page Histopathology CauseSOAFCRDIEFAITCHE B: Y DESIGN. No MiLcIrVEoRs,copKiIcDNEAYbSn,orSmPaLlEiEtNy, OTbHsYeRrOvIeDd G: LAND . 646560 TKeirlmliendalonsaDcayri:fic9e6 EAnxipmoaslureisGrsoiugpne:d oSf0f-DafyroEmxnpeocsruroepsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt.y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLOYMM,PH ANODDREE,NASLAGLLIAVNADRSY, GLSACNIDAST,IC MANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, - TPHHYARRYONIID/LGALRAYNND,K, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMAJLOE)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology PARATMHIYSRSOIINDG.GLANDS CAUSESOAFCRIDFEIACTEH B: Y DESIGN. 646560 Continued on the next page -... = -_-- Company Sanitized. Doesnotcontain TSCA C81 9H0--2D47a6y8G;avSuabgcehSrtoundiyciTnoRxaictistwyithOneGeneration Reproductive Evaluations DuPont5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IT - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646560 Continued from previous page Histopathology : No MiLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NASLALGILAVNADRSY, GSLCAINADTS,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNGODLEA,ND,THYMUS, WTIHTYHROOIPDTIGCLANNDE,RVE`,TRASCKHIENA,, MESAOMPMHAARGYUSG,LANPDHAR(YFNEKM/ALLAE)R,YNXO,VAREIYEES(.S) MUATRERROUWS,, NUROISNEARIY&BLIAI,DDENRO,SEFEIMIIUR/&KNIEVE JOINT, STERNUM, BONE ORGANPSARNAOTTHYERXOAIMDINGELDA:NDS 646565 TKeirlmliendalonSaDcaryi:fic1e24 AEnxipmoaslureisGrsoiugpned: o1f-fMonftrhomRenceocvreorpysy - Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHbEAsReTr,veSdKELETAL MUSCLE, SPLEEN, IALOERUTMA,, PBRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNGOLDAEN,D,THYMUS, TPHHYARROYIIXD/LGALRAYNNDK,, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINB,SOPMHAAMGMUASR,Y FGELMAUNRD/K(NFEEEWALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, 646565 Continued on the next page -..- = -_-- `Company Sanitized.DoesnotconTtSaCAiC8n1 9H02-4D7a6y8:GavSaubgeehSrtourdiyc TinoxRiactistywith One Generation Reproductive Evaluations DuPont:5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IT - 0 mg/kg/day Sex: Females Animal Ret Microscopic & Macroscopic Findings 646565 Continued from previous page Histopathology LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. CAUSESOAFCRDIEFAITCHE B: Y DESIGN. No MiKcIDrNoEsYcSo,picSPLAEbEnNo,rmaTlHiYtRyOIODbsGeLrAvNDed : 646580 TKeirlmliendalonSaDcayri:fic1e24 AEnxipmoaslureisGrsoiugpned: oLf-fNonftrhomRenceocvreorpysy Gross Pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLaUNlGiSt,y OHbEAsReTr,vedS:KELETAL WUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLOYMM,PH -- ANODDREE,NAL`SAGLLIAVNADRSY, GL`ASCNIDNST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNND,X, PEAVREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y FGLEAMNUDR/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology : CauSESOAFCRDIEFAITCHE B: Y DESIGN. 546580 Continued on the next page --.. won `Company Sanitized. Doss not contain TSCA C81 H.24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646580 Continued from previous page Histopathology + No MiLcIrVEoRs,copKiIcDNEAYbSn,ormSaPLlEiEtNy, ObTsHeYrRvOeIdD G:LAND 646501 TKeirlmliendalonSaDcaryi:fic1e24 . AEnxipmoaslureisGrsoiugpne:d oLf-fMonftrhomReneccorvoeprsyy Gross Pathology KIDNEYDSILA:TATION, RIGHT, PELVIS. CYST, RIGHT, 210f DINMETER. No MaLIcVrEoRs,copLiUNcGSA,bnoHErAmRaTl,itySKOEbLsEeTrALveMdUSCLE, SPLEEN, AORTA, BRAIN, CSEPCIUNMA,L CCOORLDO,N, STROEMCATCUHM,, MDUEOSDEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPAVNACRRYEAS, -- SGLCAINNDTSI,C NMEARNVDEI,BULPAIRTUILTYAMRPYH GNLOADNE,D, TTHYHMYURSO,IDAGDLRAENNDA,L GLANDS, EPVAER(AST)HYWRIOTIHD GOLPATNIDCS,NERTVREA,CHESAK,IN,ESMOPAHMAMGAURSY, GLPHAANRDYN(XF/ELMAARLYEV)N,K, SOTVEARRNIUEMS,, NUTOESREUS, URINARY BLADDER, PENUR/KNEE JOINT, Histopathology : KIDNEYHSYDRONEPHROSTS, UNILATERAL, moderate. CAUSE`SOAFCRDIEFAITCHE B: Y DESIGN. 546581 Continued on the next page .... pre Company Sanitized. Doesnotcontain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Sudy in Rats withOne-Generation Reproductive Evaluations DuPont5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646581 Continued from previous page Histopathology No MiLIcVrEoRs,copSiPcLEEANb,norTmHaYlRiOtIyD OGLbAsNeDrved : 646586 KTeirlmliendalonSaDcaryif: ic1e24 EAnxipmoaslureisGrsoigunped: 1of-fNonftrhomRneeccorvoeprsyy Gross Pathology : No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, TALOERUTMA,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANDODREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNND,K, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y - GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER. Histopathology : CAUSESOAFCRDIEFAITCHE B: Y DESIGN No MiLIcVrEoRs,copKiIcDNEAYbSn,orSmPaLlEiEtNy, ObTsHeYrRvOeIdD G: LAND -- es `Company Sanitized. Does not contain TSCA CBI 9F-02-4D7a6y8:GaSvuabgcehrSotnuidcyTionxRiactistywith One-Generation Reproductive Evaluations DuPont5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IT - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 6a6588 KTeirlmliendalonSaDcaryif: ic1e83 AEnxipmoaslureisGrsoigunped: o3f-fNonftrhomReneccorvoeprsyy Gross Pathology : . No MaLIcVrEoRs,copKiIDcNEAYbSn,ormSPaLlEiEtNy, OTbHsYerRvOeIdD GLAND, PARATHYROID GLANDS Histopathology KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal. CAUSE`SOAFCRDIEFAITCHE B: Y DESIGN. No MiLIcVrEoRs,copSiPcLEEANb,noTrHmYaRlOiItDy OGbLsAeNrDved : 6a6s92 - TKeirlmliendalonsDaacyri:fic9e6 AEnxipmoaslureisGrsoiugpned: o9f0f-DafyroEmxpnoescurroepsy Gross Pathology No MaLcIVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TEJREIJCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, 546592 Continued on the next page .... --- we Company Sanitized. Does not contain TSCA CBI H24768: Subchvoric Toxicity 90-Day Gavage Study in Rats withOne.Generation Reproductive Evaluations DuPont-5990 -~ INDIVIDUAL ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646592 Continued from previous page Gross Pathology No M`aTcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHyYROObIsDerGvLAeNdDS:, TRACHEA, ESOPHAGUS, GPLHAARNYDVN(XF/ELMAARLYEN)K,, OEVVAE(RSI)ES,WITUHTEROUPST,ICURNEIRNVAER,Y SBKLIAND,DERM,AMMARY FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LIVERFA: TTY CHANGE, MEDIAN CLEFT, mild. PANCREIANSFLA:WMATION, SUBACUTE/CHRONIC, FOCAL, minimal PARATMHIYSRSOIINDG.GLANDS : CAUSE`SOAFCRDIEFAITCHE BY DESIGN. - No MiKIcDrNoEsYcSo,picLUNAGbSn,orHmEaAlRiTt,y OSbKsEeLrEvTeAdL : MUSCLE, SPLEEN, BRATN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, AIOLRETUAM,, `CGELCAUNMD,S, COMLAONND,IBURELCATRUML,YMPMHESENONDTEE,RICTHYLMYUMSP,H NAODDREE,NALSAGLLIAVNADRSY, SESCOIPAHTAIGCUSN,ERVPEH,ARYPNIKT/ULIATRAYRNYX,GLAENYDE,(S)THWYIRTOHIDOGPLTAINCD,NERTVREA,CHESAK,IN, MFAEMMMUARR/YKNEGELAJNODIN(TF,EMASLTEE)R,NUMO,VARBIOENSE,MAURTREORWU,S,NOURSIENAIR&Y IBIL,ADDNEORS,E ore w ORGANPSARNAOTTHYERXOAIMDINGELDA.NDS ois `CompanySanitized. DoesnotconTtSaCAiCBnI H-24768: Subchroric Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646597 KTeirlmliendalon SaDcaryif: ic1e83 AEnxipmoaslureisGrsoiugpned: o3f-fMonftrhomRenceocvreorpysy Gross Pathology : . No MaLIcVrEoRs,copKiIDcNEAYbSn,ormSPaLlEiEtNy, OTbHsYeRrOvIeDd GLAND, PARATHYROID GLANDS Histopathology LiverFATTY CHANGE, MEDIAN CLEFT, minimal KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. THYROIPDYEGLLOANNEDPHR:ITIS, UNILATERAL. minimal CAUSEAOLFTERDAETAITOHN, COLLOTD, minimal. `SACRIFICE BY DESIGN. - No Mi`scerLoEsEcNopic Abnormality Observed 646612 KTeirlmliendalon SaDcaryif: ic9e6 AEnxipmoaslureisGrsoiugnped: o9f0f-DafyromExnpeocsruorpesy Gross Pathology No MAaLOIcRVrTEoARs,,copBKRiIAcDINNEA,YbSn,oSrPLmIUaNNAlGLiSt,CyORHODEb,AsReTrS,vTeOMdSAKCE:HL,ETADLUODMEUNSUCML,E, JESJPULNEOEMN., NAIODLDEREUE,MN,AL`SPAGALLNIACVNRADERSAY,S,GLSACCNEIDCASUT,MI,CMCNAEONRLDVOIENB.,ULAPRREICTTLUUYIMMT,PAHRMYENOSGDLEEAN,NTDE,RTIHYCMULSY,MPH 646612 Continued on the next page ... -_-- on `Company Sanitized. Doesnot contain TSCA CBI H24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont5990 --- INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS bose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 6a6612 Continued from previous page Gross Pathology : No MaTcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHyYROOIbDseGrLvAeNdDS, PHARYN/LARYNX, EVE(S) WITH OPTIC NETRRVAEC,HEAS,KINE,SOMPHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY ByLADDER, Histopathology : KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. CAUSE`SOAFCRDIEFAITCHE B: Y DESIGN. No MiLIcVrEoRs,copLUiNcGSA,bnoHErAmRaTl,itSyKEOLbEsTeArLveMdUS:CLE, SPLEEN, AORTA, BRAIN, CSBPCIUNMA,L CCOORLDO,N, SRTEOCMTAUCMH,, DMUEOSDEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPVAANCRRYEAS, - GSPLCAAIRNANDTTSIH,CYRONMEIARDNVDEGI,LBAUNLPDAISRT,ULIYTTRMAAPRCHYHEGNALO,ADNED,E,STOPHTHYHAMYGURUSOS,I,DADGPLRHAEANNRDAY,LNKG/LLAANRDYSN,, EOYVEA(RSI)ES,WITUTHEROUPST,ICURNEIRNVAER,Y SBKLIAND,DERM,AMMFAERMYURG/LKANNEDE J(OFIENMTA,LE), STERNUM, BONE MARROW, NOSE I & If, NOSE III & IV Tons -- `Company Sanitized. Does not containTSCA C81 H-24768: Subchronic Toxicity '90-Day Gavage Study in Rats withOne-Generation Reproductive Evaluations DuPont-5990 -- TNDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IT - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 6a6613 TKeirlmliendalonSaDcaryif: ic1e24 AEnxipmoaslureisGrsoiugpned: o1f-fMonftrhomReneccorvoeprsyy Gross Pathology : No MaALOIcRVrTEoARs,,copKBiIRcDANINEA,YbSn,oSrPmILaUNNlAGiLSt,CyORHODEb,AsReTrS,vTOeMdSAKCE:HL,ETDAULODMEUNSUCML,E,JESJPULNEUEMN,, NIOLDEEU,M, 'SPAALNTCVRAERAYS,GLACNEDCSU,M, MACONLDOINB,ULARRECTLUYMM,PHMENOSDEEN,TERTIHYCMULSY,MPH TAHDYRREONIADL GGLLAANNDD,S, PSACRIAATTHIYCROINDERVGEL,ANDPSI,TUTIRTAACRHYEAG,LANEDS,OPHAGUS, PGHLAARNVDNX(/FLEAMRAYLNEK),, EOYVEA(RSI)ES,WIUTTHEROUPST,ICURNEIRNVAER,Y BSKLIAND,DERM,AMMARY FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : CAUSESOAFCRDIEFAITCHE BY DESIGN. - No MiLIcVrEoRs,copKiIcDNEAYbSn,ormSaPLlEiEtNy, ObTsHeYrRvOeIdD G: LAND _-- Te `Company Sanitized. Does not contain TSCA CBI H9-02.4D7a6y8G:avSaubgeehSrotnuidcy iTnoxRiactistywith One-Generation Reproductive Evaluations DuPon-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646617 TKeirlmliendalonSDaacyr:ific96e AEnxipmoaslureisGrsoiugpned: o9f0f-DafyromExnpeocsruroepsy Gross pathology . No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, . NIOLDEEU,M,'SAPALNICVRAERAYS,GLACNEDCSU,M, MACONLDOINB,ULRAERCTLUYMM,PHMNEOSDEEN,TERTIHYCMULSY,MPH ATDHRYERNOAILD GGLLAANNDD,S, PASRCIAATTHIYCRONIEDRVGEL,ANDPSI,TUTIRTAACRHYEAG,LANEDS,OPHAGUS, GPLHAANRYDNX(/FLEAMRAYLNEK),, OEVYAE(RSI)ES,WITUHTEROUPST,ICUNREIRNVAER,Y SBKLIAND,DERM,AMMARY FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LaverINFLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. -- KIDNENYESPHROPATHY, CHRONIC PROGRESSIVE, minimal. CAUSE`SOAFCRDIEFAITCHE B: Y DESIGN. No MiLUcNrGoSs,copHEiAcRTA,bnoSrKmEaLlEiTtAyL MOUbSsCeLrEv,edSP:LEEN, AORTA, BRAIN, SPINAL CCOORLDO,N, ST"ROEMCATCUHM,, MDEUSODEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPVANACRRYEAGSL,ANDCSE,CUM, MNEARNVDEI,BULPAIRTUILTYAWRPYH NGOLDAEN,D, THTYHMYURSO,IDADGLRAENNDA,L GPLAARNADTSH,YROSICDIATGLIACNDS, 646617 Continued on the next page .... _-- To%sCompany Sanitized. Doesnotcontain TSCA CBI 9H-02-4D7a6y8:GavSaugbcehSrtonuidcy TinoxRiactistywith OneGeneration Reproductive Evaluations DuPont5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings sa6617 Continued from previous page Histopathology : No M`iTcRrAoCsHcEAo,picESOAPbHnAoGrUmSa,litPyHAROYbNsXe/rLvAeRdYIV:X, OEVYAER(SI)ES,WITUHTEROUPST,ICURNEIRNVAER,Y BSKLIAND,DERM,AMUFAERNYURG/KLNAENED J(OFIENMTA,LE), STERNUM, BONE MARROW, NOSE T & If, NOSE III & IV 646627 KTeirlmliendalonSDaacyri:fic1e24 AEnxipmoaslureisGrsoiugpned: o1f-fMonftrhomRencecorvoeprsyy Gross pathology : No MaALOIcRVrTEoARs!,copBKRiIADcINNEA,YbSn,oSrPmILaNUANlGLiSt,CyORHODEb,AsReTSr,TvOeMdSAKCE:HL,ETADLUODMEUNSUCML,E,JESJPULNEOEMN., NIOLDEEU,M, 'SPAALNICVRAERAYS,GLACNEDCSUM,, MACONLDOINB,ULARRECTLUYMM,PHMENOSDEEN,TERTIHYCMULSY,MPH -- TAHDYRREONIADL GGLLAANNDD,S, PA`SRCAITAHTYICRONIEDRVGEL,ANDPSI,TUTIRTAACRHYEAG,LANEDS,OPHAGUS, GPFLHEAAMNRUDYRN/KK(/NFLEEAEMRAYJLNOEXI),NT,OEVYAES(RTSIE)ERSN,UWMI,TUHTENROOUSPSET,ICURNEIRNVAER,Y SBKLIAND,DERM,AMMARY Histopathology + THYROAILDTEGRLAATNIDON, COLLOID, minimal. CAUSESOAFCRDIEFAITCHE BY DESIGN. 646627 Continued on the next page .... -_-- 5%6Company Sanitized. Donotecontsain TSCA CBI F9-02-4D7a6y8:GavSaubgcehSrtourdiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPon-5990 P INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646627 Continued from previous page Histopathology No MiLIcVrEoRs,copKiIDcNEAYbSn,ormSaPlLiEtEyN Observed : 646649 . KTeirlmliendalonSaDcary:ific96e AEnxipmoaslureisGrsoiugpned: o0f-fDafyroEmxpnoescurroepsy Gross Pathology No MAaLOIcRVrTEoARs.,copKBiRIcADINNEA,YbSn,oSrPmLIUaNNlAGiLSt,CyORHODEb.AsReTrS,vTOeMdSAKCE:HL,ETDAULODMEUNSUCML,E, JESJPULNEUEMN,, NIOLDEEU,M,'SAPLAINCVRAERAYS,GLACNEDCSU,M, `MCAONLDOINB.ULRAERCTLUYMM,PHMNEOSDEEN,TERTIHYCMULSY,MPH TAHDYRREONIADL GGLLAANNDD,S, P`ASRCAITAHTYIRCOINDERVGEL,ANDPSI,TUTIRTAACRHYEAG,LANEDS,OPHAGUS, - GPLHAANRDYNX(/FLEAMRAYLNEK),, OEVYAER(SI)ES,WITUHTEROUPST,ICURNEIRNVAER,Y FEMUR/KNEE JOINT, STERNUM, NOSE BSKLIAND,DERM,ANGGARY Histopathology : LIvERIN: FLAMMATION, SUBACUTE/CHRONIC, FOCAL, minimal. SeLEENPIG: UENT INCREASED, minimal. THYROAILDTEGRLAATNIDON, COLLOID, minimal CAUSESAOFCRDIEFAITCHE B Y DESIGN. 646649 Continued on the next page .. -_-- 937 CompanySanitized. Doesnot conTtSaCAiCnBI F-24768: Subehronic Toxicity 2900:-DayGGaavvaageSSttuuddyyiinnRRaattsswwiitthhOOnnee.GGeenneerraattiioonnRReepprroodduuccttiivvee EEvvaalluuaattiioonnss DDuuPPoonntt:55999900. ~ INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IT - 0 ma/ka/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646609 Continued from previous page Histopathology 6asss2 No MiKcIrDNoEsYcSo,picLUNAGbSn,ormHEaAlRiTt,y OSbKsELeErTvAeLd MUSCLE, AORTA, BRAIN, CGSELPCAIUNNMDA,SL, CCOOWLRAODNN,D,IBSUTRLOEMACATRCUHML,,YMP`MDHEUSONEDONEDTNEEU,MR,ITCHJYELMJYUUMSNP,UHM,ANDODRIEEL,ENUAMLS,AGLLIPAVANNADCRSRY,EAS, TSRCAICAHTEIAC, NEERSVOEP,HAGPUIST,UITPAARRYYNGEL/ALNADR,VIPXA,RATHYROID GLANDS, EOSYTVEEA(RRSNI)UEMS,,WITUBHTOENREOUPSTM,AIRCRUORNWEI,RNVAENR,OYSSEBKLIAIND,D4ERMI,iA,MUFNAEORMSYUER/GKLINAIETNED&J(OIFIVENMTA,LE), TKeirlmliendalonSaDcaryi:fic1e24 AEnxipmoaslureisGrsoiugpned: o1f-fNonftrhomRneeccorvoeprsyy Gross Pathology : - No MAaLOIcRVrTEoARs,,copBKRiIAcDINNEA,YbSn,oSrPmILaNUNAlGLiSt,CyORHODEb,AsReTrS,TvOeMdSAKCE:HL,ETADLUODMEUNSUCML,E, JESJPULNEUEMN,, NAIODLDEREUE,MN,ALSAPGALLNIACVNRADERSAY,S,GLSACCNEIDCASUT,MI,CMACNOENLRDOVINEB.,ULARPREICTTLUUYIMMT,PAHRYMNEOGSDLEEAN,NTDE,RTIHYCMULSY,MPH TPHHYARRYONIXD/LGALRAYNND,X, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y FGELANNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, 646652 Continued on the next page .... -_-- ETH Company Sanitized. Donotecontsain TSCA Cal H:24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont 5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IT - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 6ages2 Continued from previous page Histopathology CAUSESOAFCRDIEFAITCHE B: Y DESIGN No MiLcIrVEoRs,copKiIcDNEAYbSn,ormSaPLlEiEtNy, ObTsHeYrRvOeIdD GLAND 646659 KTeirlmliendalonsDaacyrif: ic96e AEnxipmoaslureisGrsoiugpned: o9f0f-DafyroEmxpnoescurroepsy Grose Pathology : No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH - A`NTDOHDRYEER,NOAILSDAGGLLLIAAVNNADDR,SY, GPLASARCNAIDTASHT,YIRCOMIANDENRDVGIELB,AUNLDAPSRI,TLUYTIRMTAPACHRHYENAOG,DLEA,NEDS,TOHPYHMAUGSU,S, GPLHAANRDYI/(FLEAMRAYLNEK),, OEVYAER(SI)ES,WITUHTEROUPST,ICURNEIRNVAER,Y BSKLIAND,DERM,AMMARY FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVERFATTY CHANGE, MEDIAN CLEFT, minimal CAUSESAOFCRDIEFAITCHE B: Y DESIGN. 646659 Continued on the next page .... _--_-- 5. `Company Sanitized. Does not contain TSCA CBI 02-4D7a6y8:GavSaubgcehSrtourdiyc TinorRiactistwyith OneGeneration Reproductive Evaluations Dupont5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IT - 0 mg/kg/day Sex: Females Animal Ret Microscopic & Macroscopic Findings 646655 Continued from previous page Histopathology : No MiKIcDrNoEsYcSo,picLUNAGbSn,ormHEaAlRiTt,y OSbKsEeLrETvAeLd M: USCLE, SPLEEN, AORTA, . PBSRAAANLICINRV,EAARSYS,PGILCNAEANCLDUSNC,,ORDCM,OALNODSNTI,OBMUARLCEAHCR,TULMYD,UMOPDMHEENSNUOEMDN,ET.ERJITECHJYUMNLUUYSMM,,PHAIDNLOERDUEEMN,,AL GPLAARNADTSH,YROSICDIATGLIACNDNSE,RVET,RACPHIETAU,ITAERSOYPHGALGAUNSD., TPHHYARRYOIIXD/LGALRAINND,K, : OEVYAE(RSI)ES,WITUHTEROUPST,ICURNEIRNVAER,Y SBKLIAND,DERM,AMMFAERMYURG/LKANNEDE J(OFIENMTA.LE), STERNUM, BONE MARROW, NOSE I & If, NOSE III & TV sags6s TKeirlmliendalonSaDcary:ific5e6 AEnxipmoaslureisGrsoiugnped: o3f0f-DafyromExnpeocsruroepsy Gross Pathology ~ No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JESJPULNEUEMN,, NAIODLDEREGE,MN,ALSAPGALLNIACVNRADERSAY,S,GLSACCNEIDCASUT,MI,CMCANOENLRDOVINEB.,ULARPREICTTLUUYIMMT,PAHRYMENGOSDLEEAN,NTDE,RTIHYCMULSY,MPH TPHHYARRYONIXD/LGALRAYNND,K, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOWPHAAMGMUASR,Y GFLEAWNUDR/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE. URINARY BLADDER, 646665 Continued on the next page .... EH -- CompanySaniized. Does notconTtSaCAiCnI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPoni-5990 --- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646665 Continued from previous page Histopathology : cavSE`SOAFCRDIEFAITCHE BY DESIGN. No MiLcIVrEoRs,copKiIDcNEAYbSn,ormLaUNlGiSt,y OHbEAsReTr,vedSKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIXD/LGALRAYNND,X, PEAVREA(TSH)YRWOIITDHGOLPANTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y FGELMAUNRD/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,UM,UTEBROUNSE, MAURRRIONWA,RYNOBLSAEDDIER&, II, NOSE or av 646676 TKeirlmliendalonSaDcary:ific96e EAnxipmoaslureisGrsoiugpned: oSf0f-DafyromExnpeocsruroepsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE,NA'LSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, 646676 Continued on the next page .. --------------------ol-- s ------------------ `Company Sanitized. Doesnotcontain TSCA Cal H9.02-4D7a6y8G:aSvuabgcehrSotnuidcyTionxRiactistywithOne.Generation Reproductive Evaluations DuPont5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : II - 0 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646676 Continued from previous page Gross Pathology : No MaTcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHyYROObIsDerGvLAeNdDS:, TRACHEA, ESOPHAGUS, . GPFLHEAAMRNUYDRN/XK(/NFLEEAEMRAYLJNEOK)I,,NT,EOYVEAS(RTSIE)ERSN,UWMI,TUHTENROOUSPSET,ICURNEIRNVAER,Y BSLKAIND,DERM.AMMARY Histopathology : LIveRINFLAWMATION, SUBACUTE/CHRONIC, FOCAL, minimal. `THYROAILDTEGRLAATNIDON:, COLLOID, minimal. CAUSESOAFCRIDFEIACTEH B Y DESIGN. No MiKcIDrNoEsYcSo,picLUNAGbSn,orHmEaAlRiTt,y OSbKsEeLrEvTeAdL : MUSCLE, SPLEEN, AORTA, - BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PHINLOEDUEM,, SALIVARY GLANDS MANDIBULAR LYMPH NODE, THYMUS, ADRENAL TGRLAACNHDESA,, SCEISNOTPIHCAGUNSE,RVEP,HARPYINTXU/ILTAARRYYNXG,LAND, PARATHYROID GLANDS, EOYVEA(RSI)ES,WITUHTEROUPST,ICURNEIRNVAER,Y SBKLIAND,DERM,AMUFAERMYURG/LKANNEDE J(OFIENMTA,LE), STERNUM, BONE MARROW, NOSE I & Ii, NOSE III & IV - = Company Sanitized. Does not contain TSCA C81 2H90-0-2D47a6y8G:GaavvSauggbceehSSrttouurddiyyciiTnnoRxRiaactsistywwiitthhOOnneeGGeenneerraattiioonnRReepprroodduuccttiivveeEEvvaalluuaattiioonnss DDuuPPoonntt.55999900 --- INDIVIDUAL ANTHAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 64502 TKeirlmliendalonSaDacyrif: ic96e AEnxipmoaslureisGrsoiugpned: o0f-fDafyromExnpeocsurroepsy Gross Pathology : No MAaLOIcRVrTEoARs,,copKBiRIcADINNEA,YbSn,oSrPmILaNUNAlGLiSt,CyORHODEb,AsReTSr,TvOeMdSA:KCEHL,ETADLUODMEUNSUCML,E,JESJPULNEUEMN,, ANIODLDREEUE,MN,AL`SPAGALLNIACVNRADERSAY,S,GLSACCNEIDCASUT,MI,C`MNCAEONRLDVOIENB,.ULRPAEIRCTTLUUIYMTM,APRHYMENOSGDLEEAN,NTDE,TRHIYCMULSY.MPH GTPLHHAYANRRDYONIKD(/FLGEALMRAAYNLNDE,K),, `OEPVYAAERRA(TSIH)EYSR,WOIITUDHTEGRLOUAPSNT,DISC,URNEITRRNVAAECR,HYEABS,KLIANDE,DSEORPM,HAAMGMUASR,Y FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : KIDNEYISNFLAMMATION, LYMPHOID, CORTICAL, minimal. - CAUSESOAFCRDIEFAITCHE BY DESIGN. No MiLIcVrEoRs,copSiPLcEEANb,norTmHaYlRiOtIyD OGbLsAeNrDved : _--_-- ae Company Saniized. DoesnotcontTSaCAiCBnI H-24768: Subehronic Toxicity 90-Day Gavage Study in Rais withOneGeneration Reproductive Evaluations DuPont:5990 --_ INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/ka/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 6a6522 KTeirlmliendalonSDaacyr:ific96e EAnxipmoaslureisGsriogunped: o$f0f-DafyromExnpeocsruroepsy Gross Pathology No MAaLOIcRVrTEoARs,,copKBRIiADcINNEA,YbSn,oSrPmLIUaNNlAGiLSt,CyORHODEb,AsReTrS,TvOeMSdAKCEHL,ETDAULODMEUNSUCMLE,, JESJPULNEUEMN,, NIOLDEEU,M,'SAPLAINCVRAERAYS,GLACNEDCSU,M, MACONLDOINB,ULARRECTLUYMM,PHMENOSDEEN,TERTIHYCMULSY,MPH A`TDHRYERNOAILD GGLLAANNDD,S, PA`SRCAITAHTYIRCONIEDRVGEL,ANDPSI,TUTIRTAACRHYEAG,LANEDS,OPHAGUS, GPLHAARNYDIV(CF/LEAMRAYLNEX), OEVVAER(ISE)S,WITUHTEROUPST,ICURNEIRNVAER,Y BSLKAIDN,DERM,AMMARY FEMUR/KNEE JOIN, STERNUM, NOSE Histopathology : THYROAILDTEGRLAATNIDON:, COLLOID, minimal. - causeSOAFCRIDFEIACTEH BY DESIGN. No uiLIcVrEoRs,copKiIDcNEAYbSn,ormSaPlLiEtEyN Observed : 646531 TKeirlmliendalonSDaacyr:ific1e83 EAnxipmoaslureisGrsoiugpned: o3f-fMonftrhomRenceocvreorpysy Gross Pathology 646531 No MaLIcVrEoRs,copKiIDcNEAYbSn,ormSPaLlEiEtNy, OTbHsYeRrOvIeDd Continued on the next page .... G: LAND, PARATHYROID GLANDS -_-- Tus Company Sanitized. Does not contain TSCA Cal F-24768: Subchronic Toxicity 90-Day Gavage Sty in Rats with One-Generation Reproductive Evaluations DuPont-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646531 Continued from previous page Histopathology CAUSESOAFCRDIEFAITCHE B Y DESIGN. . No miLIcVrEoRs,copKiIDcNEAYbSn,orSmPaLlEiEtNy, ObTsHeYrRvOeIdD G:LAND 646567 KTeirlmliendalonSaDcary:ific9e6 EAnxipmoaslureisGrsoiugpned: o9f0f-DafyromExnpeocsruorepsy Gross Pathology PITUITLAARRGYE,GLmAiNlDd.: No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, --- AIOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULTAHRYRLOYIMDPHGLNAONDDE,, THYMUS, EOPYVAEAR(RASIT)EHSY,WRIOUTITHDERGOULPSAT,NIDCSU,RNEIRNTVAREAR,CYHEBSALK,AIND,DEESRMO,PAHMAMFGAEURMSYU,RG/KLPNAHENAERDYJN(OXPI/ENLATAL,REY)N,X, STERNUM, NOSE Histopathology KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal. 646567 Continued on the next page .... _--_--m rr -------- `CompanySanitized. Doesnot conTtSaCAiCBnI 9H0--2D47a6y8G:avSaubgcehSrtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day sex: Females Animal Ref Microscopic & Macroscopic Findings 646567 Continued from previous page Histopathology : PITUITNOARMYICGRLOASNCDOPIC EVIDENCE OF MACROSCOPIC FINDING. CAUSESAOFCRDIEFAITCHE B: Y DESIGN. No MiLIcVrEoRs,copSiPLcEEANb,norPmIaTlUiItTyAROYbGsLeArNvDe,d T: HYROID GLAND sa6568 KTeirlmliendalonSDaacryif: ic1e83 EAnxipmoaslureisGrsoiugpned: o3f-fMonftrhomRenceocvreorpysy Gross Pathology : No MLaIcVrEoRs,copKiIDcNEAYbSn,ormSaPlLEiEtNy, OTbHsYeRrvOeIdD G:LAND, PARATHYROID Histopathology : KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROIADLTEGRLAATNIDON:, COLLOID, minimal. CAUSE`SOAFCRDIEFAITCHE B| Y DESIGN No MiLIcVrEoRs,copSiPcLEAEbNnormality Observed : GLANDS _-- re CompanySanitized. DoesnotconTtSaCAiCBnI 9204-7D6ay8G:avSaugbechSrtoundiyciTnoRxaitciswtyith One-GenerationReproductiveEvaluations DuPont5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Aninal Ref Microscopic & Macroscopic Findings 646576 TKeirlmliendalonSaDcaryi:fic9e6 - AEnxipmoaslureisGrsoiugpned: o9f0f-DafyromExnpeocsruorepsy Gross Pathology : +No MaLAOIcRVrTEoARs,,copBKiRIcADINNEA,YbSn,oSrPLmIUaNNAlGLiSt,CyOROHDbE,AsReTrS,vTOeMdSAKCEHL,ETADLUODMEUNSUCML,E, JESCPULNEUEMN,, ANIODLDEREUE,MR,'ALSAPGALLNIACVNRADERSAY,S,GLSACCNEIDCASUT,MI,CWANCEONRLDVOIENB,.ULARPREICTTLUUIYMTM,APRHYMENGOSDLEEAN,NTDE,RTIHYCMULSY,MPH GTPLHHAAYNRRYDONIKD(/FLGEALMRAAYNLNDEK,),, `OPEAVYRAEAR(TISHE)YSR,WOIITUDTHEGRLOUAPSNT,DISC,URNEITRRNVAAECR,HYEASB,KLIANDE,DSEORPW,HAAMGMUASR,Y FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology THYROAILDTEGRLAATNIDON:, CAUSE OF DEATH COLLOTD, minimal. - SACRIFICE BY DESIGN. No MiLIcVrEoRs,copKiIcDNEAYbSn,orSmPaLlEiEtNy Observed : - a CompanySanitized. DoesnotconTtSaCAiGanl H9-02-4D7a6y8G:avSaubgcehSrtoundiyc iTnoxRiactistywith OneGeneration Reproductive Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646595 TKeirlmliendalonSaDcaryif: ic9e6 AEnxipmoaslureisGrsoigunped: o9f0f-DafyromExnpeocsruroepsy Gross pathology No maLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHbEAsReTr,vedS:KELETAL MUSCLE, SRLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDNST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIXD/LGALRAYNNDK,, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y FGELMAUNRD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal -- CAUSE`SOAFCRDIEFAITCHE B: Y DESIGN No MiLcIVrEoRs,copSiPcLEEANb,norTmHaYlRiOtIyD OGLbAsNeDrved : ous `Company Sanitized. Does not contain TSCA CBI H24768: Subchronic 90.Day Gavage Study TinoxRiactistywithOne.Generation Reproductive Evaluations DuPont:5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref icroscopic & Macroscopic Findings sase21 TKeirlmliendalonSDaacyrif: ic9e EAnxipnoaslureisGrsoiugpned: o9f0f-DafyroEmxpnoescurroepsy Gross Pathology No MaLcIrVEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT.OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST.ICMANENRDVIEB,ULAPRITULYIMTZAHRYNOGDLEA,ND.THYNUS, TPHHAYRRYONIXD/LGALRAYNND,K, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPMHAAMGGUASR,Y FGLEAMNUDR/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology seuemHyEMATOPOTESIS, INCREASED, minimal. --- CAUSESOAFCRDIEFAITCHE BY DESIGN. No MiLcIVrEoRs,copKiIDcNEAYbSn,orTmHaYlRiOtIyDObGsLeArNvDed : sus625 TKeirlmliendalonSaDcaryif: ic1e83 AEnxipnoaslureisGrsoiugpned: o3f-fMonftrhomRenceocvreorpysy Gross Pathology No maLIcVrEoRs,copKiIcDNEAYbSn,ormSPaLlEiEtNy, ObTsHeYrRvOeIdD G:LAND, PARATHYROID GLANDS 646625 Continued on the next page -... ws CompanySanilized. DoesnotcontTSaCAiCnBI 9H02-4D7a6y8:GaSvuabgcehrSotnuidcyToinriRcatistywith One-Generation Reproductive Evaluations DuPont:5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/ka/day Sex: Females Aninal Ref Microscopic & Macroscopic Findings 646625 Continued from previous page Histopathology KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROIADLTEGRLAATNIDON:, COLLOID, minimal ' CAUSE`OSAFCRDIEFAITCHE BY DESIGN. . No MiLIcVrEoRs,copSiPcLEAEbNnormality Observed : 646626 TKeirlmliendalonSaDcaryif: ic1e83 AEnxipnoaslureisGrsoiugpned: o3f-fMonftrhomRenceocvreorpysy Gross Pathology : No MaLcIVrEoRs,copKiIDcNEAYbSn,ormSPaLlEiEtNy, ObTsHeYrRvOeIdD G:LAND, PARATHYROID GLANDS Histopathology : CAUSESOAFCRIDFEIACTEH B: Y DESIGN. No MiLIcVrEoRs,copKIiDcNEAYbSn,orSmPaLlEiEtNy, ObTsHeYrRvOeIdD G:LAND T550`Company Sanitized. Doesnot contain TSCA CBI H9-02-4D7a6y8G:avSaubgeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 546635 TKeirlmliendalonSDaacyr:ific96e AEnxipmoaslureisGrsoiugpned: oSf0f-DafyromExnpeocsruorepsy Gross Pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULIYTMAPRHYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIED/LGALRAYNND,K, PAEYREA(TSH)YROWIIDTHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology : THYROAILDTEGRLAATNIDON, COLLOID, minimal. -_ CAUSE`OSAFCRDIEFAITCHE B Y DESIGN. No MiLIcVrEoRs,copKiIcDNEAYbSn,ormSaPlLiEtEyN Observed os1`Company Sanitized. DossnotcontTSaCAiCBnI H9.02-4D7a6y8:GaSvuabgcehrSotnuidcy TinoxRiactistywithOne-Generation Reproductive Evaluations DuPont5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646636 TKeirlmliendalonSaDcary:ific1e83 EAnxipmoaslureisGrsoiugpned: o3f-fNonftrhomRenceocvreorpysy Gross Pathology : TH*Y" ROOINDLGYLOANNED T: HYROID PRESENT AT TRIMMING, NO THYROID WEIGHTS WERE TAKEN No MaLIcVrEoRs,copKiIcDNEAYbSn,orSmPaLlEiEtNy, ObTsHeYrRvOeIdD G: LAND, PARATHYROID GLANDS Histopathology : THYROAILDTEGRLAATNIDON, COLLOID, minimal. CAUSESOAFCRDIEFAITCHE B Y DESIGN. - No MiLcIVrEoRs,copKiIDcNEAYbSn,ormSaPlLiEtEyN Observed : sa6660 TKeirlmliendalonsaDcaryif: ic96e EAnxipmoaslureisGrsoigunped: oSf0f-DafyromExnpeocsruorepsy Gross Pathology : No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCAECLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUENN,TERJIEJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULIYTMAPHRYNOGDLEA,ND,THY= MUS, 646660 Continued on the next page -... oe `CompanySanitized. Does not conTtSaCAiCnBI H9-02-4D7a6y8:GavSaugbeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPon-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646660 Continued from previous page Gross Pathology No Ma`TcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHyYROObIsDerGLvAeNdDS, TRACHEA, ESOPHAGUS, GPLHAANRDYNK(/FLEAMRAYLNEX),, OEVYAER(SI)ES,WITUHTEROUPST,ICUNREIRNVAER,Y SBKLIAND,DERM,AMMARY FEMUR/KNEE JOINT, STERNUM, NOSE . Histopathology THYROAILDTEGRLAATNIDON:, COLLOID, minimal. CASESOAFCRDIEFAITCHE B Y DESIGN. No MiLIcVrEoRs,copKiIcDNEAYbSn,ormSaPlLiEtEyN Observed : 646664 - KTeirlmliendalonSaDcayri:fic9e6 Exposure Group : Animal is signed oSf0f-DafyromExnpeocsruorepsy Gross Pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLaUNlGiSt,y OHbEAsReTr,vedS:KELETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, 646664 Continued on the next page ... To53`CompanySanitized. Does notcontain TSCACBI 910.2-4D7a6y8:GaSvuabgeehrSotnuidcy TinoxRiactistywithOGneeneration Reproductive Evaluations DuPont-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 mg/kg/day Sex: Females Aninal Ref Microscopic & Macroscopic Findings pee Continued from previous page Gross Pathology No Ma`TcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHyYROObIsDerGvLAeNdDS, TRACHEA, ESOPHAGUS, GPLHAARNYDNX(/FLEAMRAYLNEK),, OEVYAER(SI)ES,WITUHTEROUPST,ICURNEIRNVAER,Y BSKLIAND,DERM,AMGARY FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROIADLTEGRLAATNIDON:, COLLOID, minimal. CAUSE`SOAFCRDIEFAITCHE BY DESIGN. No MiLIcVrEoRs,copKiIDcNEAYbSn,ormSaPlLiEtEyN Observed 64673 - TKeirlmliendalonSaDcaryif: ic96e AEnxipnoaslureisGrsoigunped: o9f0f-DafyroEmxpnoescurroepsy Gross Pathology No MaLcIrVEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,ALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNGODLEA,ND,THYMUS, 646673 Continued on the next page -... EZH `Company Saniized. Does not contain TSCA CBI H9-02.4D7a6y8:GavSaubgcehSvtoundiyc TinoxRiactistywithOne.Generation Reproductive Evaluations DuPont5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : IV - 25 ma/ka/day Sex: Females Aninal Ref Microscopic & Macroscopic Findings 645673 Continued from previous page Gross Pathology No Ma`TcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHyYROOIbDserGLvAeNdDS:, TRACHEA, ESOPHAGUS, GPLHAANRDYNK(/FLEAMRAYLNEK),, OEVYAER(ISE)S,WITUHTEROUPST,ICUNREIRNVAER,Y BSKLIAND,DERM,AMMARY . FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : THYROIADLTEGRLAATNIDON:, COLLOID, minimal. CAUSE`SOAFCRDIEFAITCHE BY DESIGN. No MiLIcVrEoRs,copKiIDcNEAYbSn,ormSaPlLiEtEyN Observed : 955 Company Sanitzed. Does not contain TSCA CBI 9H0-2-4D7a6y8:GavSaubgeehSrtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont:5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ret Microscopic & Macroscopic Findings 646501 TKeirlmliendalonSaDcaryi:fic9e6 AEnxipmoaslureisGrsoiugpned: o9f0f-DafyromExnpeocsruroepsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,vedS:KELBTAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNGOLDEA,ND,THYMUS, TPHHYARRYOIINDK/GLLAARNYDN,X, `EPVAREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)T,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology : LaverHY: PERTROPHY, CENTRILOBULAR, minimal --- KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. sevenHEMATOPOIESIS, INCREASED, minimal. `THYRO`IADLTGELRAANTIDON:, COLLOID, minimal. CAUSESOAFCRDIEFAITCHE B: Y DESIGN. oe Company Sanitized.Does notcontain TSCA CBI H-24768: Subchronic 90-Day Gavage Study Toxicity in Rats withOne.Generation Reproductive Evaluations DuPont5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646505 TKeirlmliendalonSDaacyrif: ic96e AEnxipmoaslureisGrsoiugpned: o9f0f-DafyromExnpeocsruroepsy Gross Pathology PITUILTAARRGYE.GLAND : uTeRDSLAR:GE. No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL'SAGLLTAVNADRSY,GLSACNIDAST,ICMANENRDVIEB,ULTAHRYRLOYIMDPHGLNAONDDE,, THYMUS, EPYAER(AST)HYWRIOTIHD OGLPATNIDCS,NERTVREA,CHESAK,IN,ESMOPAHMAMGAURSY, GLPAHANRDIIN(KF/ELNAARLYEV)N,X, OVARIES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVERHYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, mild. spreeHEM:ATOPOTESTS, INCREASED, minimal. THYROIADLTEGRLAATNIDON:, COLLOID, minimal. UTERUDSI:LATATION, LUMEN, mild. 546505 Continued on the next page .... To57`CompanySanitized. Doesnot conTtSaCAiCBnI H9-02.4D7a6y8:GavSaugbcehSrtoundiyc TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 546505 Continued rom previous page Histopathology : CAUSESOAFCRDIEFAITCHE B: Y DESIGN 646510 TKeirlmliendalonsaDcary:ific9e6 . EAnxipmoaslureisGrsoiugpned: o9f0f-DafyroEmxpnoescurroepsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKELETAL MUSCLE, SPLEEN, ATOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYOVINDX/GLLAARNYDI,K, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y - GFLEAMNUDR/K(NFEEEMALJEO)I.NT,OVASRTIEERSN,IM,UTENROUSSE, URINARY BLADDER, Histopathology : LIVERHYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal SPLEENHEMATOPOTESIS, INCREASED, minimal THYROAILDTEGRLAATNIDON:, COLLOID, minimal. 546510 Continued on the next page -.. - = `CompanySanitized. Doesnot conTtSaCAiCBnI 9H0-2-4D7a6y8:GaSvubacgherSotnuidcy TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont-5990 ~ INDIVIDUAL ANINAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646510 Continued rom previous page Histopathology : CAUSE`OSAFCRDIEFAITCHE B: Y DESIGN. 646533 TKeirlmliendalonSaDcaryif: ic1e83 AEnxipmoaslureisGrsoigunped: o3f-fMonrtohmRenceocvreorpysy Gross Pathology : * ANIMAL CAME TO NECROPSY AK, ONLY FLOURINE AND HISTO SAVED.. No MaLIcVrEoRs,copKiIcDNEAYbSn,orSmPaLlEiEtNy, ObTsHeYrRvOeIdD G:LAND, PARATHYROID GLANDS Histopathology - SPLEEPNIG: MENT INCREASED. THYROID GLAND : CAUSEMIOSFSIDNEGA.TH : `SACRIFICE BY DESIGN No MiLIcVrEoRs,copKiIcDNAEbYSnormality Observed : ORGAN`TSHYNROOTIDEGXLAMAINNDED: To55`Company Sanitized. Does not contain TSCA CBI H9-02-4D7a6y8G:avSaugbeehSrtonuidcy TinoxRiactistywith OneGeneration Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646534 KTeirlmliendalonSaDcary:ific9e6 AEnxipmoaslureisGrsoiugpned: o9f0f-DafyromExnpeocsruorpesy Gross pathology : No MaLcIrVEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y OHbEAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, TAOLRETUAM,, PBRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICWANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, PTHHAYRRYONIXD/LGALRAYNND,X, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y FGELAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology : LIVERHY: PERTROPHY, CENTRILOBULAR, minimal - THYROIADLTEGRLAATNIDON:, COLLOID, minimal. CAUSE`SOAFCRDIEFAITCHE B Y DESIGN No MiKcIDrNoEsYcSo,picSPALbEEnNormality Observed : Se Company Sanitized. Does not containTSCA CBI 9H0--2D47a6y8G:avSaubgcehSrtoundiye iTnoxRiactistywithOne-Generation Reproducive Evaluations DuPont:5990 ~ INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day sex: Females Animal Ret Microscopic & Macroscopic Findings 646556 TKeirlmliendalonSaDcaryi:fic9e6 AEnxipmoaslureisGrsoiugpned: o9f0f-DafyromExnpeoscurroepsy Gross Pathology PITULIATRAGREY.GLAWD : . MAMMARLYARGGEL,ANVDEN(TFREAMLA.LE) : No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NASLAGLLIAVNADRSY,GLSACNIDAST,ICMANENRDVIEB,ULTAHRYRLOYIMDPHGLNAONDDE,, THYMUS, EPVAER(AST)HYWRIOTIHD OGLPATNIDCS,NERTVREA,CHESAK,IN,ESOOVPAHRAIGEUSS,, UPTHEARRUYSN,K/LUARRIYNNAKR,Y BLADDER, FEMUR/KNEE JOTNT, STERNUM, NOSE Histopathology LaverHYPERTROPHY, CENTRILOBULAR, minimal. KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEENHEM+ ATOPOIESIS, INCREASED, minimal. THYROIADLTEGRLAATNIDON:, COLLOID, mild MAMMARHYYPEGRLTARNODPH(YF,EMAFLOEL)LIC:ULAR, minimal. 646556 Continued onHYtPheERPnLeAxStIAp,ageLOBUL-.A.-R, mild. o61`CompanySanitized.Doasnotcontain TSCA C81 H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats withOne.Generation Reproduce Evaluations DuPont-5990 Pe INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day sex: Females Animal Ref Microscopic & Macroscopic Findings 646556 Continued from previous page Histopathology CAUSESOAFCRDIEFAITCHE B: Y DESIGN. 646578 TKeirlmliendalonSaDacyri:fic96e AEnxipmoaslureisGrsoiugpned: o9f0f-DafyroEmxpnoescurroepsy Gross Pathology + No maLcIrVEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHbEAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARROYINKD/LGALRAYNND,K, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y - GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology : LIVERHY: PERTROPHY, CENTRILOBULAR, minimal. "THYROAILDTEGRLAATNIDON:, COLLOID, mild CAUSE`OSAFCRDIEFAITCHE B Y DESIGN. 646578 Continued on the next page -.. -se CompanySanitized. Doesnot contain TSCAC81 H9-02-4D7a6y8:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generation ReproductiveEvaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646578 Continued from previous page Histopathology : No MiKIcDrNoEsYcSo,picSPLAEbEnNormality Observed : 646608 TKeirlmliendalonSaDcayrif: ic9e6 . AEnxipmoaslureisGrsoiugpned: o9f0f-DafyroEmxpnoescurroepsy Gross Pathology : No MaLcIrVEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y HOEbRsReTr,vedS:KELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NA`LSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, PTHHAYRRYONIKD/LGALRAYNNDK,, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y -_ GFLEAMNUDR/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology : THYROAILDTEGRLAATNIDON:, COLLOID, mild. CAUSESOAFCRDIEFAITCHE B Y DESIGN No MiLcIrVEoRs,copKiIcDNEAYbSn,ormSaPlLiEtEyN Observed : 56 `CompanySanitized.Doesnot contTSaCAiCnBI 'H9-02-4D7a6y8G:avSaubgeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 6a6624 TKeirlmliendalonsaDcaryif: ic96e AEnxipmoaslureisGrsoigunped: o9f0f-DafyromExnpeocsruroepsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,veSdKELETAL MUSCLE, SPLEEN, AIOLRETUMA,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDNST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNGODLEA,ND,THYMUS, TPHHYARRYONIXD/LGALRAYNND,K, PAEVREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology : LIVERHYPERTROPHY, CENTRILOBULAR, minimal. --_ KIDNEYNSE.PHROPATHY, CHRONIC PROGRESSIVE, minimal SPLEENHE:MATOPOTESIS, INCREASED, minimal. THYRO`IADLTGELRAANTDION:, COLLOID, mild. ChusE`SOAFCRDIEFAITCHE BY DESIGN. tt CompanySanitized. DossnotconTtSaCAiCBnI H9L02-4D7a6y8:GavSaugbeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPon-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646629 TKeirlmliendalonSDaacyrif: ic9e6 AEnxipmoaslureisGrsoiugpned: o9f0f-DafyroEmxpnoescurroepsy Gross Pathology : . No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,veSdKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIED/LGALRAYNND,X, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,DM,UTENROUSSE, URINARY BLADDER, histopathology LIVERHY: PERTROPHY, CENTRILOBULAR, minimal - `THYRO`IADLTGELRAANTDION:, COLLOID. mild. CAUSEHOYFPERDTERAOTPHHY:, FOLLICULAR, minimal. `SACRIFICE BY DESIGN. No MiKcIDrNoEsYcSo,picSPALbEnENormality Observed : 565 `CompanySanitized. Does not containTSCA CBI H9-02-4D7a6y8:GavSaubgcehSrtourdiyc TinoxRiactistywithOne-Generation Reproductive Evaluations DuPont-5990 - INDIVIDUAL ANINAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646630 KTeirlmliendalonSDaacyr:ific1e83 EAnxipmoaslureisGrsoiugpned: o3f-fNonftrhomRenceocvreorpysy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormSPaLlEiEtNy, ObTsHeYrRvOeIdD G: LAND, `PARATHYROID Histopathology KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, moderate. SpLEENPIG: MENT INCREASED, minimal. THYROAILDTEGRLAATNIDON:, COLLOID, minimal CAUSESOAFCRDIEFAITCHE BY DESIGN. No MiLcIrVoEsRcopic Abnormality Observed : 646632 TKeirlmliendalonSaDcaryi:fic1e83 AEnxipmoaslureisGrsoiugpned: o3f-fMonftrhomRneeccorvoeprsyy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormSaPlLEiEtNy, OTbHsYeRrOvIeDd G: LAND, PARATHYROID 646632 Continued on the next page .... GLANDS GLANDS S66`Company Sanitized.DoesnotcontTSaCAiCnBI 9H0--2D47a6y8G:avSaugbeehSrtoundiyc TinoxRiactistywithOne.Generation Reproductive Evaluations DuPont:5990 ~~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646632 Continued from previous page Histopathology + KIDNEY`NSEP:HROPATHY, CHRONIC PROGRESSIVE, minimal. THYRO`IADLTGELRAANTIDON:, COLLOID, mild. CAUSEOSAFC"RDIEFAITCHE BY DESIGN. No MiLIcVrEoRs,copSiecLEAEbNnormality Observed : 546633 TKeirlmliendalonSDaacyr:ific96e EAnxipmoaslureisGrsoiugpned: o9f0f-DafyromExnpeocsurroepsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, - ATOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NA'SLALGILAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIGD/LGALRAYNND,K, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, 646633 Continued on the next page . - ee `Company Sanitized. Doss not contain TSCA CBI F-24768: Subchronic Toxicity 90-Day Gavage Study in Rats withOne-Generation Reproductive Evaluations DuPont 5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646633 Continued from previous page Histopathology : LIverHY: PERTROPHY, CENTRILOBULAR, minimal. SPLEENHEMATOPOTESTS, INCREASED, minimal. THYROAILDTEGRLAATNIDON:, COLLOID, moderate. . CAUSE`SOAFCRDIEFAITCHE BY DESIGN. No MiKcIDrNoEsYcSopic Abnormality Observed : 646634 KTeirlmliendalonSaDacyrif: ic1e83 EAnxipmoaslureisGrsoiugpned: o3f-fNonftrhomRneeccorvoeprsyy Gross pathology : - KIDNEYSSMALL, RIGHT, IRREGULAR. No MaLIcVrEoRs,copSiPLcEEANb,norTmHaYlRiOtIyD GOLbAsNeDr,vedPAR: ATHYROTD GLANDS Histopathology KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. THYROIADLTEGRLAATNIDON, COLLOID, minimal 646634 Continued on the next page --.. - ee Company Sanitized.Doesnot contain TSCA CBI H9-02-4D7a6y8:GavSaubgeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VI - 100 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646634 Continued from previous page Histopathology CAUSE`SOAFCRDIEFAITCHE B: Y DESTGN. No MiLIcVrEoRs,copSiPcLEAEbNnormality Observed : sa6656 TKeirlmliendalonsaDcary:ific1e83 AEnxipmoasluraisGrsoiugnpe:d o3f-fNonftrhomRenceocvreorpysy Gross Pathology : No MaLcIrVEoRs,copKiIcDNEAYbSn,ormSaPLlEiEtNy, ObTsHeYrRvOeIdD GLAND, PARATHYROID GLANDS Histopathology : - KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, mild. THYROIADLTEGRLAATNIDON:, COLLOID, minimal. CAUSE`OSAFCRDIEFAITCHE B Y DESIGN. No MiLIcVrEoRs,copSiPcLEAEbNnormality Observed : Toe. `CompanySanitized. Doesnot contain TSCAC81 H-24768: Subhronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont5990 --- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646506 TKeirlmliendalonsaDcayr:ific1e24 AEnxipmoaslureisGrsoigunped: o1f-fNonftrhomRenceocvreorpysy Gross Pathology : 5 No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL'SAGLLTAVNADRSY, GL`ASCNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNGODLEA,ND,THYMUS, TPHHYARRYONIGD/LGALRAYNND,X, PEAVREA(TSH)YRWOIITDHGOLAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y FGELMAUNRD/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology : KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal --~ THYROAILDTEGRLAATNIDON:, COLLOID, mild. CAUSE`SOAFCRDIEFAITCHE B Y DESIGN. No MiLIcVrEoRs,copSiPcLEAEbNnormality Observed : - Company Sanitized. Doesnot contain TSCA C81 H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats with OneGeneration Reproductive Evaluations DuPont5990 --_ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646508 KTeirlmliendalonSaDcary:ific1e24 EAnxipmoaslureisGrsoiugpned: o1f-fNonftrhomReneccorvoeprsyy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUECLE, SPLEEN, ATOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC.OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDNST,IC`MNAENRDVIEB,ULPAIRTULYIMTPAHRYNGODLEA,ND,THYMUS, TPHHYARRYONIXD/LGALRAYNND,K, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology : KIDNE`YNSEPHROPATHY, CHRONIC PROGRESSIVE, mild - THYRO`IADLTGELRAANTDION:, COLLOID, moderate. CAUSEHYOPFERDTERAOTPHHY, FOLLICULAR, minimal `SACRIFICE BY DESIGN. No MiLIcVrEoRs,copSiPcLEEANbnormality Observed - `Company Sanitized. Doesnotcontain TSCA CBI 9H-02-4D7a6y8G:avSaugbeehSrtoundiycTionxRiactistywith One- Generation Reproductive Evaluations DuPont5990 _ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day sex: Females Animal Ref Microscopic & Macroscopic Findings 646509 KTeirlmliendalonSaDcary:ific9e6 AEnxipmoaslureisGrsoiugpned: o0f-fDafyromExnpeocsruorpesy Gross pathology No MaLcIrVEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,IC`MNAENRDVIEB,ULAPRITULYIMTPAHRYNGODLEA,ND,THYMUS, TPHHYARRVONIXD/LGALRAYNND,X, PAEVREA(TSH)YRWOIITDHGLOAPNTDISC, NTERRAVEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEWAJLEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology LaverHYPERTROPHY, CENTRILOBULAR, mild. - KIDNEY`NSEP:HROPATHY, CHRONIC PROGRESSIVE, minimal. seLEENPIGMENT INCREASED, minimal THYROIHDYPEGRLTARNODPH+Y, FOLLICULAR, mild CAUSEALOTFERDAETAITOHN,: `COLLOID, mild. SACRIFICE BY DESIGN 646509 Continued on the next page .... - = CompanySanitized. Doesnotcontain TSCA C81 9H0-2-4D7a6y8:GaSvuabgeehrSotnuidcy TinoxRiactistywithOne-Generation Reproducive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646509 Continued from previous page Histopathology No MiLUcNrGoSs,copHEiAcRTA,bnoSrKmEaLlEiTtAyL MOUbSsCeLrEv,edAO:RTA, BRAIN, SPINAL CORD, RSETCOTMUAMC,H, `EDUSOEDNETNEURMI,C JLEYJMUPNHUMN,ODEI,LEUSMA,LIVPAANRCYREGALSA,NDSC,ECUMMA,NDCIOBLUOLNA,R . LPYIMTPUHITANORDYE,GLATNHDY,MUSP,ARAADTRHEYNRAOLIDGLGALNADNSD,S, STCRIAACTHIECA,NEREVSEO,PHAGUS, , GPLHAANRDYI/(FLEAWRAYLNEX),, O'EVVAER(ISE)S,WITUHTEROUPST,ICUNREIRNVAER,Y BSKLIAND,DERM,AMMARY oFErVUeR/KwNvEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE 646523 KTeirlmliendalonSaDcaryif: ic1e83 AEnxipmoaslureisGrsoigunped: o3f-fMonftrhomRenceocvreorpysy Gross pathology - No MaLIcVrEoRs,copKiIcDNEAYbSn,ormSPaLlEiEtNy, ObTsHeYrRvOeIdD G:LAND, PARATHYROID GLANDS Histopathology : LIVERIN: FLAMMATION, SUBACUTE/CHRONIC, FOCAL, mild. KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal. THYROAILDTEGRLAATNIDON:, COLLOID, mild CAUSESOAFCRDIEFAITCHE BY DESIGN. 646523 Continued on the next page .... -_-- `Company Sanitized. Does not contain TSCA CBI F-24768: Subchvonic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646523 Continued from previous page Histopathology : No miScPrLoEsEcNopic Abnormality Observed : 646528 TKeirlmliendalonsaDcaryi:fic1e83 - AEnxipmoaslureisGrsoiugpned: o3f-fNonftrhomRenceocvreorpysy Gross Pathology : No MaLcIrVEoRs,copKiIcDNEAYbSn,ormSaPlLEiEtNy,ObTsHeYrRvOeIdD G:LAND, PARATHYROID GLANDS Histopathology : KIDNENYESPHROPATHY, CHRONIC PROGRESSIVE, minimal THYROIADLTEGRLAATNIDON:, COLLOID, mild. - CAUSESOAFCRDIEFAITCHE B Y DESIGN No MiLIcVrEoRs,copSiPcLEAEbNnormality Observed - `CompanySanitized.Dossnot conTtSCaAiCBnI H9L02-4D7a6y8G:avSaugbcehSrtourdiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day sex: Females Animal Ref Microscopic & Macroscopic Findings 646535 KTeirlmliendalonSDaacyrif: ic9e6 AEnxipmoaslureisGrsoiugpned: o9f0f-DafyroEmxpnoescurroepsy Gross Pathology . MANDIBDUISLCAORLOLRYAMTPIHONN,ODEBIL: ATERAL No MaLcIVrEoRs,copKiIDcNEAYbSn,orLmUaNlGiSt,y OHbEAsReTr,vedSKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NNEORDVE,E, `SPAILTIUVIATRAYRGYLAGNLDASN,D, `TTHHYYMRUSO,IDADGLRAENNDA,L GPLAARNADTSH,YROSICDIATGLIACNDS, TERYAEC(SH)EA,WITEHSOPOHPATGIUCS,NERPVHEA,RYNSKKI/NL,ARYMNAXM,MARY GLAND (FEMALE), SOTVEARRNIUEMS,, NUOTESREUS, URINARY BLADDER, FENUR/KNEE JOINT, Histopathology : --~ LIVERHY: PERTROPHY, CENTRTLOBULAR, mild. SPLEENPIG: MENT INCREASED, minimal. MANDICBOUNLGAERSTLIYOMNP,H NmiOlDdE. THYROIADLTEGRLAATNIDON:, COLLOID, mild. PARATHHYYPREORITDROGPLHAYN,DSFO: LLICULAR, minimal. 646535 Continued onMItShSeINnGe.xt page ---- - = CompanySanitized. Doesnotcontain TSCACBI H-24768:Subchronic Toxicity 90-Day Gavage Study in Rats withOne-Generation Reproductive Evaluations DuPont-5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646535 Continued from previous page Histopathology EVE(S)HEWMIOTRHRHAOGPETIICNFNLEARMVMEAT:ION (BLEEDING PROCEDURE). CAUSE`SOAFCRDIEFAITCHE BY DESIGN. No MiKIcDrNoEsYcSo,picLUNAGbSn,ormHaEAlRiTt,y OSbKsEeLrEvTeAdL M:USCLE, AORTA, BRAIN, CSEPCIUNMA,L CCOORLDO,N, STROEMCATCUHM,, MDUEOSDEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPVAANRCRYEAS, GGLLAANNDD,S, "TTRHAYCMHUESA,, ABDSROPEHNAAGLUSG,LANPDHSA,RYNSKC/ILAATRIYCNKN,ERVSEK,IN,PITUITARY MFEAMMUMRA/RKYNEGELAJNODIN(TF,EMASLTEE)R,NUMO,VARBIOENSE, MAURTREORWUS,, NOUSREINAIRY& IBIL,ADDNEORS,E Ir aw ORGANPSARNAOTTHYREOXIADMINGELDA:NDS - 646536 TKeirlmliendalonSaDcaryif: ic96e AEnxipmoaslureisGrsoigunped: o9f0f-DafyromExpnoescurroepsy Gross Pathology LaverLARGE. 646536 Continued on the next page ... - Company Sanitized. Does not contain TSCA GBI H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats withOneGeneration Reproductive Evaluations DuPont5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646536 Continued from previous page Gross Pathology : No MaKIcDrNoEsYcSo,picLUNAGbSn,orHmEaAlRiTt,y OSKbEsLeErTvAeLd M:USCLE, SPLEEN, AORTA, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODNEENSUEMN,TERJIECJUNLUYMM,PH INLOEDUEM,, GSLAALNIDVSA,RYSCGLIAANTDISC, NEMRAVNED,IBUPLIATRUITLAYRMYPHGLNAONDDE,, TTHHYYMRUOSI,D GALDARNEDN,AL EPYAER(AST)HYWRIOTIHD OGLPATNIDCS,NERTVREA,CHESAK,IN,ESMOAPMHAMGAURSY,GLPAHNARDYN(XF/ELMAARLYEN)K., SOTVEARRNIUEMS,, NUOTESREUS, URINARY BLADDER, FEMUR/KNEE JOINT, Histopathology + LaveHY: PERTROPHY, CENTRILOBULAR, moderate. KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, moderate. SeLEENPIG: UENT INCREASED, minimal. - THYROHIEDMAGTLOAPNODTE:STS, INCREASED, mild. CAUSEALOTFERDAETAITOHN,: COLLOID, moderate. SACRIFICE BY DESIGN. No MiLUcNrGoSs,copHEiAcRTA,bnoSrKmEaLlEiTtAyL MOUbSsCeLrEv,edAO:RTA, BRAIN, SPINAL CORD, RSETCOTMUAMC,H, `MDEUSOEDNETNEURMI,C JLEYJMUPNHUMN,ODEI,LEUSMA,LIVPAARNYCREGALSA,NDSC,ECUMMA,NDICOBLUOLNA,R LPYIMTPUHITANORDYE,GLATNHDY,MUSP,ARAADTRHEYNRAOLIDGLGALNADNSD,S, SCTIRAACTHIECA,NEREVSEO,PHAGUS. 646536 Continued on the next page .... - Company Sanitized. DossnotconTtSaCAiCBnI H902-4D7a6y8:GavSaubgcehSrtoundiyc TinoxRiacittywithOneGeneration Reproductive Evaluations DuPon-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VITI - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646536 Continued from previous page Histopathology No MiPcHrAoRsYcNXo/pLiAcRYANbXn,ormEVaEl(iSt)y OWIbTsHerOvPeTdIC: NERVE, SKIN, MAMMARY : GFLEAMNUDR/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,UM,UTEBROUNSE, MAURRRIONWA,RYNOBSLAEDDIER&, II, NOSE ora w . 646540 TKeirlmliendalonSaDcayri:fic1e24 AEnxipmoaslureisGrsoiugpned: o1f-fNonftrhomRenceocvreorpysy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedS:KELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NALSALGILAVNADRSY, GLSACNIDNST,IC MANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, - TPHHYARRYONIED/LGALRAYNND,X, PAEVREA(TSH)YROWIIDTHGLOAPNTDISC, NETRRVAEC,HEAS,KINE.SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology KIDNE`YNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal THYRO`IADLTGELRAANTDION:, COLLOID, moderate 646540 Continued onHYtPheERTnReOxPtHYp,ageFOL-L.I--CULAR, mild. O78 `Company Sanitized. Donotecontsain TSCA CBI H9-02-4D7a6y8:GaSvuabgcehrSotruidcy iTnoxRiactistywithOne.Generation Reproductive Evaluations DuPont:5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646540 Continued from previous page Histopathology CAUSE`SOAFCRDIEFAITCHE B: Y DESIGN No MiLIcVrEoRs,copSiPcLEAEbNnormality Observ- ed sa6542 KTeirlmliendalonSaDcary:ific1e24 EAnxipmoaslureisGrsoiugnped: o1f-fMonftrhomRneeccorvoeprysy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, BIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUNC,ORDC.OLOSNT.OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND.THYMUS, -- `PTHHAYRRYONIXD/LGALRAYNND,K, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I.NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology : KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, moderate. THYROAILDTEGRLAATNIDON:, COLLOID. moderate. 646542 Continued onHYtPhEeRTnReOxPtHYp,ageFOL-L.I..CULAR, minimal -- CompanySanitized. Does not contain TSCA CBI 24768: Subchronic Toxicity 0-DayGavageStudy in Rats with One-Generation Reproductive Evaluations DuPont5990 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 6assaz Continued rom previous page Histopathology : CAUSESOAFCRDIEFAITCHE B: Y DESIGN. . Yo MiLIcVrEoRs,copSiPcLEAEbNnormality Observed: 646545 TKeirlmliendalonsDaacyrif: ic1e24 AEnxipmoaslureisGrsoiugnpe:d o1f-fonftrhomRenceocvreorpysy Gross pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,IC`MNAENRDVIEB,ULPAIRTULIYTMAPHRYNGODLEA,ND,THYMUS, - PTHHAYRRYONTXD/LGALRAYNNDK,, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMAJLEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology : KIDNE`YNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal. spremHNEM+ ATOPOIESIS, INCREASED, minimal 646545 Continued on the next page ... -_-- Company Sanitized. Doesnot contain TSCA CBI H9-02.4D7a6y8G:avSaugbcehSrotniyc iTnoxRiacsitywithOne Generation Reproductive Evaluations DuPon-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day Sex: Females Aninal Ref Microscopic & Macroscopic Findings 6asses Continued from previous page Histopathology : THYRO`IADLTGELRAANTDION:, COLLOID, mild. CAUSE`SOAFCRDIEFAITCHE BY DESIGN. . No MiLcIrVoEsRcopic Abnormality Observed : sa6san TKeirlmliendalonSaDcaryi:fic1e24 EAnxipmoaslureisGrsoiugpned: o1f-fMonftrhomRneeccorvoeprsyy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR.EASS,PICNEACLUMC,ORDC,OLOSNT.OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMw.Pn ~ ANODDREE,N'ALSAGULTAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULIYTMAPHRYNOGDLEA,ND,THYMUS. TPHHYARRYONIKD/LGALRAYNND,X, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I.NT,OVASRTIEERSN,OM,UTENROUSSE, URINARY BLADDER, Histopathology : KiowEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal. 646548 Continued on the next page ... ---- er `Company Sanitized. DoesnotcontTSaCAiCnBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats withOneGeneration Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings Pree Continued from previous page Histopathology THYRO`IADLTGELRAANTIDON:, COLLOID, moderate. CAUSEHOYFPERDTERAOTPHHY:, FOLLICULAR, minimal. SACRIFICE BY DESIGN. No MiLIcVrEoRs,copSiPcLEAEbNnormality Observed : 646577 TKeirlmliendalonSDaacyri:fic9e6 AEnxipmoaslureisGrsoiugpned: o0f-fDafyromExnpeocsruroepsy Gross Pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, -- ATOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,IC`MNAENRDVIEB,ULPARITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYOVINDX/GLLAARNYDN,K, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I.NT,OVASRTIEERSN,IM,UTENROUSSE, URINARY BLADDER, Histopathology : LIVERHY:PERTROPHY, CENTRILOBULAR, mild. 646577 Continued on the next page ... Tow Company Sanitized. Does not contain TSCA CBI H-24768:Subehronic Toxicity 90-Day Gavage Study in Rats withOne.Generation Reproductive Evaluations DuPont5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VITI - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646577 Continued from previous page Histopathology SeLEENPIG: MENT INCREASED, minimal. | THYROIHDEMAGTLOAPNODIE:SIS, INCREASED, minimal. `HAYLPTEERRTARTOIPOHNY,, COFLOLLOLIIDC,ULAmRo,dermaintiemal. 3 UTERUDSI:LATATION, LUMEN, minimal. CAUSE`SOAFCRDIEFAITCHE B Y DESIGN. No MiKcIrDoNEsYcSo,picLUNAGbSn,orHmEaAlRiTt,y OSbKsEeLrEvTeAdL M:USCLE, AORTA, BRAIN, C`SEPCIONMA,L CCOOLRODN,, STROEMCATCUHM,, MDEUSODEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPVAANCRRYEAS, SGLCAINADTSI,C NMEARNVDEI,BULPAIRTULIVTMAPRIYi GNOLDAEN,D,THPYAMRUAST,HYARODIRDENGALLANGDLSA,NDS, TBYRSA(CSH)EA,WITEHSOPOHPATGIUCS,NERPVHEA,RYNSKK/ILN,ARYMNAXM,MARY GLAND (FEMALE), --- MOAVRARROIWE,S, NUORSEINAIRY& BILI,ADDNEORS,E IFIEIMUR&/KINVEE JOINT, STERNUM, BONE om Company Sanitized. Does not contain TSCA CBI H-24768: Subehronic Toxicity '90-Day Gavage Study in Rats with One.Generation Reproductive Evaluations DuPont 5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646593 TKeirlmliendalon SaDcaryif: ic9e6 AEnxipmoaslureisGrsoiugpned: o9f0f-DafyromExnpeocsurroepsy Gross pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM!, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NA'LSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIWTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYONIXD/LGALRAYNND,X, 'PEAYREA(TSH)YRWOITTDHGLOAPNTDISC, NTERRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMAJLEO)I.NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology : LaverHYPERTROPHY, CENTRILOBULAR, mild. -- SPLEENPIG: HENT INCREASED, minimal. THYROIHDEMAGTLOAPNODIE:SIS, INCREASED, minimal. AHLYTPEERRATTRIOOPNH,Y, COFLOLLOLIIDC,ULAmRi,nimmailn.imal. CAUSE`SOAFCRDIEFAITCHE B: Y DESIGN. 646593 Continued on the next page .... --- CompanySanitized.Does notconTtSaCAiCnBI H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats withOne-Generation Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646593 Continued from previous page Histopathology No MiKIcDrNoEsYcSo,picLUNAGbSn,ormHaEAlRiTt,y SOKbEsLeErTvAeLd M:USCLE, AORTA, BRAIN, CSEPCIUNMA,L CCOORLDO,N, STROEMCATCUHM,, MDUEOSDEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUMS,ALIPVANACRRYEAS, * GSLCAINADTSI,C NMEARNVDEI,BULPAIRTULIYTMAPRHY GNOLDAEN,D, THPYAMRUAST,HYRAODIRDENGALLANGDLSA,NDS, BTYREA(CSH)EA,WITEHSOPOHPATGIUCS,NERPVHEA,RYNSEKI/NL,ARYMIAXM,MARY GLAND (FEMALE), SOTVEARRNIUEMS,, BUTOENREUSM,ARRUORWI,NANROYSEBLATDD&ERI,f, FENOMSUER/KINIIEE&JOIIVNT. 646599 KTeirlmliendalonSDaacyr:ific1e24 AEnxipmoaslureisGrsoiugpned: o1f-fNonftrhomRneeccorvoeprsyy Gross Pathology : -- No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLaUNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, HIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUENN,TERJIEJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHYARRYONIKD/LGALRAYNNDK,, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/X(NFEEEMALJEO)I.NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, 646599 Continued on the next page . -_ _. _ `Company Sanitized. Doas not contain TSCA CBI H9-02-4D7a6y8G:SauvbagcehrSotnuidcy iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont5990 -~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646599 Continued from previous page Histopathology KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, minimal THYROAILDTEGRLAATNIDON:, COLLOID, minimal CAUSE OF DEATH - `SACRIFICE BY DESIGN No MiLIcVrEoRs,copSiPcLEAEbNnormality Observed : 6a6601 TKeirlmliendalonsaDcary:ific1e83 AEnxipmoaslureisGrsoiugpned: o3f-fMonftrhomReneccorvoeprsyy Gross Pathology - ASNvIeMAnL.S CAME TO NECROPSY AK, ONLY FLOURINE AND HISTO TISSUE No MaLIcVrEoRs,copKiIDcNEAYbSn,orSmPaLlEiEtNy, OTbHsYeRrOvIeDd G:LAND, PARATHYROID GLANDS Histopathology : KIDNENYESPHROPATHY, CHRONIC PROGRESSIVE, mild. SPLEENPIGMENT INCREASED, minimal. 646601 Continued on the next page .... ET -- Company Sanitized. Dossnotcontain TSCA CBI `H9-02-4D7a6y8G:avSaugbeehSrtoundiyc iTnoxRiactistywithOneGeneration Reproductive Evaluations DuPont-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646601 Continued from previous page Histopathology THYROIMDISSGILNAGN.D : CAUSESOAFCRIDFEIACTEH B: Y DESIGN. No miLcIrVoEsRcopic Abnormality Observed : ORGAN`TSHYNROOTIDEGXLAMAINNDED: 646609 TKeirlmliendalonSaDcaryif: ic96e AEnxipmoaslureisGrsoigunped: o9f0f-DafyromExnpeocsruroepsy Gross Pathology - No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJEIJCUNLUYMM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNTDAST,ICMANENRDVIEB,ULAPRITULIYTMAPHRYNOGDLEA,ND,THYMUS, GTPLHHAAYRNRYDONIXD(/FLGEALMRAAYNLNDE,X),, POAEVYRAEA(RTSIH)EYSR,WOIITUDHTEGRLOUAPSNT,DISC,URNEITRRNVAAECR,HYEASB,KLIANDE,DSEORPM,HAAMGMUASR,Y FEMUR/KNEE JOINT, STERNUM, NOSE 646609 Continued on the next page .... -_-- SE CompanySanitized. DoasnotconTtSaCAiCBnI 9H02-4D7a6y8:GavSaugbcehSrtounidcy TinoxRiactistywithOne-Generation Reproductive Evaluations DuPon-5990 -- INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VITI - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646609 Continued from previous page Histopathology LIVERHY: PERTROPHY, CENTRILOBULAR, mild. seLEENPIGHENT INCREASED, minimal. . THYROHIEDMAGTLOAPNODIE:SIS, INCREASED, minimal. . AHLYTPEERRATTRIOOPNH,Y, COFLOLLOLIIDC,ULAmRi,ld.minimal ureRvSDIL:ATATION, LUMEN, minimal. CAUSESOAFCRDIEFAITCHE BY DESIGN. No MiKIcDrNoEsYcSo,picLUNAGbSn,ormHEaAlRiTt,y SOKbEsLeErTvAeLd SPINAL CORD, STOMACH, DUODENUM, JMEUJSUCNLUEM,, AOIRLTEAU,M, BRPAAINNC,REAS, CGSELCCAIUNAMDT,SI,CCNOMELARONVNDE,I,BURELPCAITRTUUNLI,YTMAMPREHYSENGLONADTNEED,R,ITCHPYLAMYRUMASPT.HHYANROODDIREDE,NGALLSAANGLDLISAV,NADRSY, --~ TERYAEC(HSE)A,WITEHSOOPPHATGIUCS,NERPVHEA,RYNSXK/ILNA.RYMNXA.M,UARY GLAND (FEMALE), MOAVRARROIWE,S, NOUSREINAIRY& BIIL,ADDNEORS,E FIIETMU&R/KINVEE JOINT, STERNUM, BONE -- _-- oR CompanySanitized.Doesnot conTtSCaAiCBnI H9-02-4D7a6y8G:avSaubgeehSrtoundiyc iTnoxRiactistwyithOneGeneration Reproductive Evaluations DuPont5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646610 TKeirlmliendalonSaDcayrif: ic9e6 or AEnxipmoaslureisGrsoiugnped: o9f0f-DafyroEmxpnoecsruorpesy Gross Pathology No MNaLOIcRVrTEoARs,,copKBRiIADcINNEA,YbSn,oSrPmILUaNNAlGLiSt,CyOROHDEb,AsReTrS,TvOeMdSAKCE:HL,ETADLUODMEUNSUCML,E, JESJPULNEUEMN,, NAIODLDEREUE,MN,A'LSAPGLALNIACVNRADERSAY,S,GL`ASCNCEIDCASUT,NI,CMNACEONRLDVOIENB,,ULARPREICTTLUUYIMMT,PAHRYMNEOGSDLEEAN,NTDE,RTIHYCMULSy,MPH G`PTLHHAAYNRRDYOIND(/FLGEALMRAAYNLNDEX,),, POEAVVREAA(RTSIH)EYSR,WOIITUDHTEGRLOUAPSNT,DISC,URNEITRNRVAAECR,HYEABS,KLIANDE,DSEORPW,HAAMGMUASR,Y FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVERHY: PERTROPHY, CENTRILOBULAR, minimal. - INENCFRLOASMIMSA,TIOINN,DISVUIBDAUCAULTEC/ECLHL,RONmIiCl,d. FOCAL, KIDNEYS minimal. SPLEENNEP:HROPATHY, CHRONIC PROGRESSIVE, minimal HPEIMGAHTEONPTOIIENSCIRSE,ASEIDN.CRmEAiSnEiDm,alminimal. THYROIADLTEGRLAATNIDON, COLLOID, minimal. CAUSEHOYFPERDTERAOTPHHY:, FOLLICULAR, minimal. 646610 Continued onSAthCeRIFneIxCtE BpYageDES.I.GN. - Company Sanilized. Doesnotcontain TSCA Cal H9L02-4D7a6y8G:avSaubgcehSrotnuiyc TinoxRiactistywithOne.Generation Reproductive Evaluations DuPont5990 = INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646610 Continued from previous page Histopathology : No MiLOcNrGoSs,copHiEcARTA,bnoSrKmEaLlEiTtAyL MOUbSsCeLrEv,edAO:RTA, BRAIN, SPINAL CORD, RSTEOCMTAUCMH,, `MDEUSOEDNETNEURMI,C JLEYJMUPNHUMN,ODEI,LEUSMA,LIVPAANRCYREGALSA,NDSC,ECUMMA,NDCIOBLUOLNA,R + PLIYTMUPIHTANORDYE,GLATNHDY,MUSP,ARAADTRHEYNRAOLIDGLGALNADNSD,S, STCRIAACTHIECA,NEREVSEO,PHAGUS, GPLHAANRDYNC(/FLEAMRAYLNEX),, OEVVEAR(IS)ES,WITUHTEROUPST,ICUNREIRNVAER,Y BSKLIAND,DERM,AMMARY FuErMUeR/KwNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE 646610 KTeirlmliendalonSaDcary:ific9e6 AEnxipmoaslureisGrsoiugpned: o0f-fDafyromExnpeoscurroepsy Gross pathology : ~ No MaLIcVrEoRs,copKIiDcNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, ATOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNOGDLEA,ND,THYWDS, TPHHYARRYONIKD/LGALRAYNND,K, `PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I.NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, 646614 Continued on the next page -... --- `CompanySanitized. Doesnot conTtSaCAiC8n1 9H0-2-4D7a6y8:GavSaubgeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPon-5990 -~ INDIVIDUAL ANTAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 6a6614 Continued rom previous page Histopathology LIVERHYPERTROPHY, CENTRILOBULAR, mild. KIDNEYNSEPH: ROPATHY, CHRONIC PROGRESSIVE, minimal. SPLEENPIG: HENT INCREASED, minimal . THYROIHDEMAGTLOAPNODTE:STS, INCREASED, minimal HALYTPEERRATTRIOOPNH,Y, COFLOLLOLIIDC,ULAsRe,vermei.ld. CAUSESOAFCRDIEFAITCHE B: Y DESIGN No MiLUcNrGoSs,copHEiAcRTA,bnoSrKmEaLlEiTtAyL MOUbSsCeLrEv,edAO:RTA, BRAIN, SPINAL CORD, SRETCOTAUCMH,, `MDEUSOEDNETNEURMI,C JLEYJMUPNHUMN,ODEI,LEUSMA,LIVPAARNYCREGALSA,NDSC,ECUMMA,NDICOBLUOLNA,R LPYIMTPUHITANORDYE,GLATNHDY,MUSP,ARAADTRHEYNRAOLIDGLGALNADNSD,S, SCTRIAACTHIECA,NEREVSEO.PHAGUS. ~ GPLHAANRDYI/(FLEAMRAYLNEX),, O'EVVAER(ISE)S,WITUHTEROUPST,ICUNREIRNVAER,Y BSKLIAND,DERM,AMMARY FoErMUaR/KwNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE - `Company Sanitized. Donotecontsain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646618 TKeirlmliendalon saDcaryif: ic1e24 EAnxipmoaslureisGrsoiugpned: o1f-fNonftrhomRneeccorvoeprsyy Gross Pathology : No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NALSALGLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULYIMTPAHRYNGODLEA,ND,THYMUS, PTHHAYRRYOVINDX/GLLAARNYDN,K, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFLEAMNUDR/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology : LIVERHY: PERTROPHY, CENTRTLOBULAR, minimal. - KIDNEYNSEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROIADLTEGRLAATNIDON:, COLLOID, moderate. CAUSEHYOPFERDTERAOTPHHY, FOLLICULAR, minimal. `SACRIFICE BY DESIGN. No Mi`ScPrLoEsEcNopic Abnormality Observed : 02 `CompanySanitized. Doesnot conTtSaCAiCBnI H-24768: Subehronic Toxicity '90-Day Gavage Study in Rats with One.Generation Reproductive Evaluations DuPont-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group: VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646620 TKeirlmliendalonSaDcaryif: ic1e83 EAnxipmoaslureisGrsoigunped: o3f-fNonftrhomRneeccorvoeprsyy Gross Pathology : . No MaLIcVrEoRs,copKiIcDNEAYbSn,orSmPaLlEiEtNy, OTbHsYeRrOvTeDd G: LAND, PARATHYROID GLANDS Histopathology LIVERFA: TTY CHANGE, MEDIAN CLEFT, minimal. CAUSESOAFCRDIEFAITCHE BY DESIGN. No MiKcIrDNoEsYcSo,picSPLAEbEnNo,rmaTlHiYtRyOIODbGsLeArNvDed 646637 --- TKeirlmliendalonSDaacyri:fic1e24 AEnxipmoaslureisGrsoiugpne:d oLf-fNonftrhomRenceocvreorpysy Gross Pathology : sToma'cUHLCER/EROSTON, GLANDULAR, 3104 DIA. 646637 Continued on the next page .... Se CompanySanitized. Does not contain TSCA CBI HL24768: Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont:5990 -~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646637 Continued from previous page Gross Pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, APOARNTCAR,EASB,RAICNE,CUMS,PICNOALLONC,ORDR,ECTDUUMO,DENNUEMS,ENTJEEJRUINCUML,YMPIHLEUNMO.DE, GSLAALNIDVSA,RYSCGILAANTDISC, NMERAVNED,IBUPLIATRUITLAYRMYPHGLNAONDDE,, TTHHYYMRUOST,D AGDLARNEDN,AL EPYAER(NST)HYWRIOTIHD OGLPATNIDCS,NERTVREA,CHESAK,IN,ESOMPAHMAMGAURSY,GLPAHNADRYN(/FLEAARLYEN)X,, SOVTAERRINEUSM,, NUTOESREUS, URINARY BLADDER, FEMUR/KNEE JOINT, Histopathology + sromacEkROS: ION/ULCER, ACUTE, minimal. `THYROAILDTEGRLAATNIDON:, COLLOID, mild CAUSEHYOPFERDTERAOTPHHY:, FOLLICULAR, minimal - `SACRIFICE BY DESIGN. No MiLIcVrEoRs,copKiIcDNEAYbSn,ormSaPlLiEtEyN Observed : `Company Sanitized.DoesnotconTtSaCAiCBnI F-24768: Subchroric Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont. 5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646650 TKeirlmliendalonSDaacyri:fic1e24 AEnxipmoaslureisGrsoiugpned: o1f-fNonftrhomRneeccorvoeprysy Gross Pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,vedSKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,IC MANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS. TPHHYARRYONIID/LGALRAYNND,K, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y FGELMAUNRD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, URINARY BLADDER, Histopathology THYROIADLTEGRLAATNIDON:, COLLOID, mild --- CAUSE`SOAFCRDIEFAITCHE BY DESIGN. No MiLIcVrEoRs,copKiIDcNEAYbSn,ormSaPlLiEtEyN Observed : 646657 KTeirlmliendalonSDaacyr:ific96e EAnxipmoaslureisGrsoiugpned: o9f0f-DafyromExnpeoscurroepsy Gross Pathology : LIVER LA: RGE. 646657 Continued on the next page .... 995 CompanySanitized. Doesnot contain TSCA CBI H9-02-4D7a6y8:GSauvbacgherSotruidcyTionxRiactistywith One-Generation Reproductive Evaluations DuPon-5990 -- INDIVIDUAL ANTMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/ka/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646657 Continued from previous page Gross Pathology + PITUILTAARRGYE,GLmAiNlDd.: No MaKcIrDNoEsYcSo,picLUNAGbSn,orHmEaAlRiTt,y OSbKsEeLrEvTeAdL M: USCLE, SPLEEN, AORTA, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PHILNEOUDME,, GSLAALNIDVSA,RYSCGILAANTDISC, NEMRAVNED,IBUTLHAYRROILDYMPGLHANNDO,DE,PATRHAYTMHUYSR,OIDADGRLEANNADLS. TERYAE(CSH)EA,WITEHSOPOHPATGIUCS,NERPVHEA,RYNSKK/INL,ARYMNAXM,UARY GLAND (FEAL), OSVTAERRINEUSM,, NUTOESREUS, URINARY BLADDER, FENUR/KNEE JOINT, Histopathology LIVERHYPERTROPHY, CENTRILOBULAR, mild. --- KIDNEYNSEPH:ROPATHY, CHRONIC PROGRESSIVE, mild. SPLEENPIG: HENT INCREASED, minimal THYROHIEDMAGTLOAPNODIE:SIS, INCREASED, mild. AHLYTPEERRATTRIOOPNH,Y, COFLOLLOLIIDC,ULAmRi,ldmild ureRUSDIL:ATATION, LUMEN, minimal. . CAUSESAOFCRIDFEIACTEH B Y DESIGN 646657 Continued on the next page .... - ew. Company Sanitized. Does not contain TSCA C81 9H0--24D7a6y8G:avSaubgeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 6a6657 Continued from previous page Histopathology No MiLUcNrGoSs,copHEiAcRTA,bnoSrKmEaLlEiTtAyL OMUbSsCeLrEv,edAO:RTA, BRAIN, SPINAL CORD, SRETCOTMUAMC,H, `WDEUSOEDNETNEURMI,C JLEYJMUPNHUMN,ODEI,LEUSMA,LIVPAARNYCREGALSA,NDSC,ECUMMA,NDICOBLUOLNA,R LPYIMTPUHITANORDYE,GLATNHDY,MUSP,ARAADTRHEYNRAOLIDGLGALNADNSD,S, STCRIAACTHIECA,NEREVSEO,PHAGUS, GPLHAANRDYI/(FLEAMRAYLNEX),, 'OEVVAER(ISE)S,WITURHINOAPRTYICBNLEARDVDEE,R, SKFIENM,UR/MAKMNMEAERJYOINT, STERNUM, BONE MARROW, NOSE I & IT, NOSE III & IV 646667 TKeirlmliendalon SaDcaryif: ic1e83 AEnxipmoaslureisGrsoiugpned: 3of-fMonftrhomRneeccorvoeprysy Gross pathology : No MaLIcVrEoRs,copKiIcDNEAYbSn,orSmPaLlEiEtNy, OTbHsYeRrOvIeDd G: LAND, PARATHYROID GLANDS Histopathology : KIDNEY`NSEP:HROPATHY, CHRONIC PROGRESSIVE, mild. spLEENPIG+ UENT INCREASED, minimal. THYRO`IADLTGELRAANTDION:, COLLOID, moderate. CAUSESOAFCRDIEFAITCHE BY DESIGN. 646667 Continued on the next page -... Se `Company Sanitized. Doesnotcontain TSCA C8I 'H9-02-4D7a6y8:GavSaubgeehSrotnuidcy TinoxRiactistywith One Generation Reproductive Evaluations DuPont-5990 ~~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646667 Continued from previous page Histopathology : No MiLcIrVoEsRcopic Abnormality Observed 64666v9 TKeirlmliendalonsaDcaryif: ic9e6 EAnxipmoaslureisGrsoiugnped: o9f0f-DafyromExpnoescurroepsy Gross pathology sv:ALOPECIA, BILATERAL, HINDLINB. No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLaUNlGiSt,y HOEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM!, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TEJREIJCUNLUYMM,PH NAODDREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULIYTMAPHRYNOGDLEA,ND,THYMUS, --_ PTHHAYRRYONIXD/LGALRAYNNDK,, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAM,AMMEASORPYHAGGLUASN,D J(OFIENMTA,LE)S,TERONVUAMR,IESN,OSUETERUS, URINARY BLADDER, PEMUR/KNEE Histopathology LIVERHYPERTROPHY, CENTRILOBULAR, mild. NIENCFRLOASMIMSA,TIOINN,DIVSIUDBUACAULTEC/ELCLH,RONmIiCn,imaFlO.CAL, minimal. 546669 Continued on the next page 9% CompanySanitized.DoesnotconTtSaCAiC8n1 H9-02-4D7a6y8G:avSaubgcehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPon-5990 - INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VIII - 500 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 646669 Continued from previous page Histopathology : SPLEENPIG: UENT INCREASED, minimal. sromACEHROSION/ULCER, ACUTE, minimal THYROAILDTEGRLAATNIDON, COLLOID, moderate. . SKIN:HYPERTROPHY, FOLLICULAR, minimal. CAUSEALOOFPEDCETAAT/HHYPOTRICHOSTS, mild `SACRIFICE BY DESIGN No MiKIcDrNoEsYcSo,picLUNAGbSn,ormHaEAlRiTt,y SOKbEsLeErTvAeLd M: USCLE, AORTA, BRAIN, CSOPLIONNA,L CROERCDT,UM,DUOMDEESNEUNMT,ERIJCEJULNYUMMP,H NIOLDEEU,M, SAPLAINVCRAERAYS,GLACNEDCSU.M, NMEARNVDEI,BULPAIRTUILTYAWRPYH GNOLDAEN,D,THPYAWRUAST,HYRAODIRDENGALLANGDLSA,NDST,RACSHCEIAA,TIC --- GELSAONPHDAG(UFSE,MALPEH)A,RYNOXV/ALRAIERSY,NX,UTEERYUES(,S) UWRIITNHARYOPTBILCADDNEERR,VE, MAMMARY FoErMUeR/KwvNEE JOINT, STERNUM, BONE MARROW, NOSE I & II, NOSE - CompanySanitized. DoesnotcontTSaCAiCBnI H9-02-6D7a6y8:GavSaugbcehSrtoundiyc TinoxRiactistywith One- Generation Reproductive Evaluations DuPont-5990 APPENDIX O REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF P; MALE RATS EE `Company Sanitized. Does not contain TSCA CBI 9H02-4D7a6y8:GavSaugbcehSrtoundiyc TinosRiactistywith OneGeneration Reproductive Evaluations Duon: 5990 - REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF Py MALE RATS EXPLANATORY NOTES Notes TestDays7286 = Cohabitation period --_-- Te Company Sanitized. Does not contain TSCA CBI H-24768:Subchronic Toxicity '90-Day Gavage Study in Rats withOne-Generation Reproductive Evaluations DuPont:5990 = INDIVIDUAL BODY WEIGHTS (grams) OF P, MALE RATS GROUP: 1-0 DOSE: MG/KG/DAY DATYESS:T 7 8a 91 8 ANIMAL NOMBER 664466449400 448932.099 s5025.133 5s2175..92 552385..86 s6a466a420d2 5S0679.24 552743.133 assssiilsa s519a5.027 664466437532 5609301069 6539811.27 665079..70 668229..11 664466335925 4597061.s2 459509027 5610050.s3 56124..43 664466430597 557652.175 5s9e3s.s3 650772..74 651824..90 664466437298 7529791027 765108046 763193030 768a2s..80 s6a4g6a46710 5545001016 s5s7e8l.s0 557822..20 559903..25 664466438803 66086'1s2 6as122l6s 643935.71 655013..76 ssaag6a3asse 5828910d9 Ssseaallss Ss614532 5537030.70 -- 6s4a6g4a0s8 5526950.10 s5a8s1l.s3 553994..14 G56l7a.s6 Tiooz ~ Company Sanitized. Doesnot contain TSCA CBI H9-02-4D7a6yG8:aSvuabgcehrSourdiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPon-5990 - INDIVIDUAL BODY WEIGHTS (grams) OF P; MALE RATS GROUP: TII-0 DOSE: 25 MG/KG/DAY TaEvSsT: 7 8a 91 9% ANIMAL NUMBER 664466438738 558049..52 559048..98 650283..78 652267..72 664466333643 5578000.53 558630..73 559873..08 661001..66 . 664466440543 568096..99 660248.053 661484..73 663661..81 664466441105 s5i7i0l0a8 5sae8lll3s 559633.94 567156..91 664466335440 454770.s9 a5o579l085 5s7i4s.l2s 559217.035 664466348617 565093..26 557766.80 568236..53 660468..21 664466340520 5604991132 56s186l118 567351..49 s6e5s9l.33 664466337276 s5s680l.a1 5576560141 s587s0l169 650858..13 664466345708 525058.58 75465s.l7s 757769..15 679190..40 - 664466343835 5a1d5i.e8 a5a1s7l.o4 453554.31 a575s8l.s9 Tioos `CompanySanitized. Doesnot conTtSCaAiCnBI 9H0.2-4D7a6y8:GaSvuabgeehrSotnuidcy TinoxRiactistywithOne-Generation Reproductive Evaluations DuPont5990 - INDIVIDUAL BODY WEIGHTS (grams) OF P, MALE RATS GROUR: V0 DOSE: 100 MG/KG/DAY DATYESS:T 7" 8s 92 9% ANIMAL NUMBER 664466334513 58495..30 5s6156..54 557357..01 555961..78 646466333506 552307..13 5s2a461l8s 552686..32 55389075.2 664466440509 554507..05 554703..82 5S4876..1 5S3e84..64 664a6g3a318? 4s99i0'ss 5522270.52 3563.917 5s4s21.29 646466339847 550774..14 558179.157 5620393s s62a4l.39 646a663a3d67 458070..42 458059..37 455200..86 459398..18 664466439556 550175..13 5523930.11 354433.57 554595..48 646466347655 5514891.53 5s36020.64 554659..36 554792..92 664166349209 546506..38 a5s7l1l1s5 548968..07 559278..93 --~ 646466437468 446558.056 as80s3ll0s SS112058 5522960.66 -we Company Sanitzed.DoesnotcontTSaCAiCnBI H24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPoni-5990 -~ INDIVIDUAL BODY WEIGHTS (grams) OF P, MALE RATS GROUP: VII-0 DOSE: 500 MG/KG/DAY DAEYSST: ANIMAL NUMBER 664466430662 664466439511 s6a466a410s5 664466439672 664466449081 664466338362 664466445421 664466339635 664466435519 kd E 2 8 44s037l.s7 aasn0lsa 4473020.31 4a7d9a0?3 as60s1il17 dS1s3o4 452973.113 5sa0a0..z8 4465380104 445770.85 448609..80 449860..27 4at3o6l9s aasoss2 a4s1si7s 4asz73.l0a 5541381141 555296037 556298.139 650346..75 3s86920165 358872.44 4509721.30 6d1l70.l08 4127641133 4437250ss 444950.000 as4i3lla7 4473750125 aa8s96ll3s 456053.53 44733.40 3590335134 4511s4l0s1 4520661.88 451329.s6 "i005 -- -- CompanySanitized.Doo notconTtSaCAiCBnI H9-02-4D7a6y8:GavSaubgcehSrtoundiyc TinoxRiactistywith OneGeneration Reproductive Evaluations DuPont 5990 APPENDIX P REPRODUCTIVE TOXICOLOGY _ INDIVIDUAL BODY WEIGHT GAINS OF P MALE RATS -- we Company Sanitized. Does not contain TSCA CBI H24768: Subchronc 90.Day Gavage Study TinoxRiactistywith One-Generation Reproductive Evaluations DuPont5990 - REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS OF Py MALE RATS EXPLANATORY NOTES Notes TestDays7286 = Cohabitation period Te Company Sanitized. Doesnotcontain TSCA CBI H9-02-4D7a6y8:GaSvuabgcehrSotruidcy TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 - INDIVIDUAL BODY WEIGHT GAINS (grams) OF Py MALE RATS Group: 1-0 DOSE: 0 MG/KG/DAY TaEvSsT: 77-88 84-91 91-98 77-98 ANIMAL NUMBER 664466444900 1120.4 1222.536 137.76 4a3l.y9 664466442002 1a619 388s1 124834 266l8s To 6e4a6e437n3 soolss 2137s3 3w1la e3s1i2s 646466339552 18s6 1al2s a9sl0o 338s1 664466345079 13716 16a8 1s1z6 2312s 6G4a66437258 22609 1280067 o2l0s sassls 66a466a46710 21970a7 1a20os 11810s aS0l0s1 664466438803 163a 122085 i7sl9e o3a5s0i0s 664466345458 215000 1290as is8i7s 4a3021 --- 64664460482.5 119305 11300018 208028 a38s5s T1008 Company Sanitized. Doesnot containTSCA CBI H9-02-4D7a6y8G:avSaubgcehSvtourdiyc TinoxRiactistywithOne.Generation Reproductive Evaluations DuPont-5990 ~ INDIVIDUAL BODY WEIGHT GAINS (grams) OF P, MALE RATS GROUP: TII-0 DOSE: 25 MG/KG/DAY DAEY5ST: 77-84 84-91 e198 77-98 ANIMAL NUMBER 664466347883 1-00.44 115s.0 138.04 a182.0 654466333643 2103026 2123133 117s8 46103 646466440943 2l1aas 114620 1186.s1 4s6a.9" 664466441105 lsels s1lss 2122.07 a4slis3 664466334500 l0e3 2477 v8i0 aaoll 664a663a8g17 2177..66 56073 2221..78 4a1d..0s 664466435402 78s7 11783.31 2s1l4s 35500.90 664166332767 l5o0 1a0s2 1197l4s a2s8l2) 664466345708 133772 13000a0 320353 ssiozl --_ 664466343835 a1l6a 167037 221338 3a2.a0 T1009CompanySanitized.Doesnot conTtSaCAiCBnI H9:02-4D7a6y8G:avSaubgcehSrtourdiyc TinoxRiactistywithOne.Generation Reproductive Evaluations DuPon:5990 - INDIVIDUAL BODY WEIGHT GAINS (grams) OF P, MALE RATS GROUP: V-0 DOSE: 100 MG/KG/DAY DATYESS:T 77-84 84-91 S198 77-98 ANIMAL NUMBER 6a646633d513 220725.1 2o0l7s 1196.86 46761.84 646466333506 .-a533 1930s6 2m120 a1sl0o 664466440909 1o7s o6wl3s 1u1l3 2a4.l8 646a6g3a3187 21350004 1132006s 1s1s5 a39l0a4 646466339847 B121s2 2306 115840 s3o4l2s 646466343467 2sl1s 15005s 18832 1a11l7 664466439656 2m0s0 1w4a6 15293 w40ls 664466436755 u18r1 u7l.y2 i2s6 32120009 664466349209 2H51z1 o1w6l8s 2816ls o7w1lss -_ 664466344786 5as 2770.s3 i1si1s 3e8a0l0 ooCompanySanitized. Dossnot containTSCACBI 9H0-2-4D7a6y8:GavSaubgeehSrotnuidcy TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont5990 - INDIVIDUAL BODY WEIGHT GAINS (grams) OF P, MALE RATS Group: VIT-0 DOSE: 500 MG/KG/DAY. DATYESS:T 77-84 84-91 o1.s8 77-98 ANIMAL NUMBER 6s4a66430862 150119 1o4l3s 152.06 23570.80 . 664466435511 1w6r9 1w1h3 w7a5 3a8l0s7 664466240158 2a.s4 1u0s0 1u5la 22778 : 664466439672 120569 13s5 -1077 311206 664466445081 186.32 2o0l6e s7l6a e18l.s4 6a5466333826 219209 19s9 23487 251425 6asa66aasa21 6126 1a2l0s1 3 ale 3197a0 646466339635 122111 18472 e92171 -3a12si 664466435519 20s7-1n3l 15287 a5212 ES Company Sanitized. Donotecontsain TSCA CBI H9-02.4D7a6y8;GavSaugbcehSrtoundiyc iTnoxRiacistywith One-Generation Reproductive Evaluations DuPont5990 APPENDIX Q REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF P; FEMALE RATS DURING GESTATION Ton Company Sanitized. Does not contain TSCA CBI 9H02.4D7a6y8:GavSaubgcehSrtoundiyc TinoxRiactistywith One-Generaion Reproductive Evaluations ~ REPRODUCTIVE TOXICOLOGY DuPont5990 INDIVIDUAL BODY WEIGHTS OF P; FEMALE RATS DURING GESTATION EXPLANATORY NOTES Footnotes a Nolitter was delivered; data were excluded from statistical analysis. b No gestation data were collected since no copulation plug was observed; howevear litter was delivered. No gestation data were collected since no copulation plug was observed; no litter was delivered d Start of gestation miscalculated; data were excluded from statistical analysis e Noitter observed; however, implantation sites were present at necropsy. Data were excluded from statistical analysis. Abbreviations -- = NoData Tion- -- Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic 90-Day Gavage Study Toxicity in Rats withOne-Generation Reproductive Evaluations DuPon-5990 - INDIVIDUAL BODY WEIGHTS (grams) OF P, FEMALE RATS DURING GESTATION Group: T1-0 DOSE: 0 MG/KG/DAY GEDSAYTSA:TION o a EY) 2 ANIMAL NUMBER 664466567535 237861.37 i32s1i.s8 d3e6s4i.s6 a4s652.l2l sa64g6s6e2s2a 3258521.30 328975..31 230221.65 S30186.80 646466555206 238620020 3m3l7.s1 431778.72 a4s8e0l.s4 64ca6s5e0a3an 28o9l07 32o9o.1 35oo9l.0 46o5l.9 64sa6g6e0s0] 239162.069 334323l.z4 336678.02 445684.d1 664a6g6s0s62a 235052..84 238090.068 331179..74 430373.30 664466559517 2207980103 333134011 33468652 441453.37 p6rae6544 331167..33 3355471033 339955.75 449967139 66a4665562902 32250113 2374780l6d 328901..21 428960.33 ~ p6r4e66e6n8 33a021.3a 3383120038 43165330 44e611l.73 AaBa RDB oSEDp -SES E F Sor wowwE wwmm Company Sanitized. Does notcontain TSCA CBI H9.02-4D7a6y8G:avSaubgcehSrtoundiyc TinoxRiactistywithOneGeneration Reproductive Evaluations DuPont-5990 INDIVIDUAL BODY WEIGHTS (grams) OF P; FEMALE RATS DURING GESTATION GROVE: 1-0, DOSE: 25 MG/KG/DAY GESaTvAsT:ION 712 ANIMAL NUMBER 664466565398 3310050.75 3354010.08 337922..77 asoe1s..4 6644665569184 2305881.s5 d39a5s.s4 3318581.54 a338t9l.e6 6644665507430 230087..85 331446..54 333599..93 a3427s.66 6465872 272.1 274.5 284.6 219.5 sa6466653219a 237058.025 3338290.38 d39e2a.l7 440a0e.10 646603 207.6 327.5 337.1 428.7 6s4a66557594a 237250029 3314300.15 3345235.34 432462..46 6644666576244 3321100.67 336253..98 339371.80 439322..69 6644665584434 230826.070 331081.s1 332335..41 338270.048 646595 28306 312 3517 43lia - 6465584 301.9 325.1 322.6 330.9 6644665657302 3318650.01 33a269l0s9 337444..78 434501..25 Hots CompanySanitized. DoesnotconTtSaCAiC8n1 H-24768: Subehronic Toxicity `90-Day Gavage Study in Rats withOne.Generation Reproductive Evaluations DuPont5990 = INDIVIDUAL BODY WEIGHTS (grams) OF P, FEMALE RATS DURING GESTATION GROUP: VI-0) DOSE: 100 MG/KG/DAY GeDsAYTSa:TION 7 12 ANIMAL NUMBER 6a6547 296.4 335.9 373.7 489.0 64sa6s660676a 330732030 33666al4s s31i3.s2 a3s2sl2 . 64s6as6s0200 30_0.2 33p9y.5 Ll 372.9 ol 470.8 | 646466569438 220703058 232924088 337285..08 435921..39 646546 2872 31307 3436 aail2 6s4a6s6e7611a 239063..57 333383..48 336367..36 435444..46 sa6521 2033 32007 343.5 390.6 66a4s665a9502 226064..95 2391960.70 333345..58 343180..14 6a65552 3147 3340 3363 337.0 6466054 2013 325.5 329.5 326.7 664a66651859a 224032.010 234157..06 324560..96 2a537m..31 --_ 6644666542772 3300350.18 331256.020 331561.94 436116..42 6466754 36.6 322.3 325.0 323.1 -ee CompanySanitized. Doesnot conTtSCaAiCnBI H-24768: Subehronic Toxicity 90.DayGavage Study in Rats with Ore-Generation Reproductive Evaluations DuPont-5990 - INDIVIDUAL BODY WEIGHTS (grams) OF P; FEMALE RATS DURING GESTATION GRovR: VITI-0 DOSE: 500 MG/KG/DAY cesDATYaST:ION o 7 1a 2 ANIMAL NUMBER sas662 212.9 260.2 293.9 352.7 s64a666s28332 220779.011 331273.098 33334..42 3a205.3 664466563199 3321020050 333481..00 330820.011 a4d6e4..e5 6466288 278.7 315.4 323.3 315.1 6466162 291.4 3115 320.6 309.9 s6a46665a6L34 329005.58 3294039.24 337061..72 435003..35 664466551722 2283871000 229182..64 2299831108 233937..44 646566 27311 283.4 31909 3839 6644666507200 2276891.72 228938.13 331113.l4s 338561.22 6644666556522 2209181.15 3210330.04 330319.038 4310530.30 ~ 6a6663d s466a0e 294.9 323.3 384.5 202.7 304.8 326.2 264.2 664466553724 2280861173 332234073 335650..30 aadz0d..0a Tio CompanySanitized. DoesnotconTtSaCAiC8n1 H9-02.4D7a6y8:GaSvugbeehSrtoundiyc TinoxRiactistywith One-Generaion Reproductive Evaluations DuPont:5990 APPENDIX R REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS OF P, FEMALE RATS DURING GESTATION -- ew Company Sanitzed. Does not contain TSCA CBI 'H9.02-4D7a6y8:GavSaubgcehSrtoundiyc TinoxRiactistywith OneGeneration Reproducive Evaluations DuPont:5990 --_ REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS OF P; FEMALE RATS DURING GESTATION EXPLANATORY NOTES Footnotes a Nolitter was delivered; data were excluded from statistical analysis. b No gestationdatawere collected since no copulation plug was observed; however a litter `was delivered. No gestation data were collected since no copulationplugwas observed; no litter was delivered. d Start of gestation miscalculated; data were excluded from statistical analysis. e Nolitier observed; however, implantation sites were present at necropsy. Data were excluded from statistical analysis. Abbreviations = NoData - we Company Sanitized. Doesnotcontain TSCA CBI 9H0--24D7a6y8G:avSaubgcehSrotnuidcy TionxRiactistywith One-Generation Reproductive Evaluations DuPon-5990 ~ INDIVIDUAL BODY WEIGHT GAINS (grams) OF P, FEMALE RATS DURING GESTATION GROUP: T1-0 DOSE: 0 MG/KG/DAY GDeAsYTSA:TION 07 74 121 0-21 ANIMAL NUMBER 664466655735 425a.1 4a2l.s8 1e00l.s6 118083.i5 ssaag66528252 1332.010 378.38 s5a.z5 e2l6l.s0 664466555206 2550.61 337a6 6e3l2m 1127060025 646503 sla 200s a06l3 17602 s6d48666044ab 3o6n.8 3=38 0---.-9 1o6os 646651 2513 258 sels 15200 6sa4g6s6s026a 3S31068 219689 715..66 13501.29 6a64g6s5s9T1 335681 a3l0a1 asellss 116156070 664466654460 a3l8o6 3408l4s 1100l1s4 11880006 6464665562902 2286033 31138 5-1006801 13696.20 - 66aa66666s8a 331s5 3al0o2 7ss6.4 116409030 Tw Company Sanitized. Does not contain TSCA Cal 9H0--24D7a6y8G:avSaubgcehSrtoundiyc TinoxRiactistywithOne-Generation Reproductive Evaluations DuPont5990 - INDIVIDUAL BODY WEIGHT GAINS (grams) OF P, FEMALE RATS DURING GESTATION GROUP: 1-0 DOSE: 25 MG/KG/DAY . - GEDSAYTSA:TION ANIMAL NUMBER 6asa66s6s3s8 6644665569182 sa64665570342 sa65872 sa64c6653219a 646603 64sa6s5s7s5aa 6saa66s667022 6s64aa6s65559846432 6465582 6644665657302 07 74 met 021 33960.34 25200.78 10e8s.i7s i19s5t.s9 w16i5 1236.60 e1l2l 132018 2370.06 2125.49 1se7r 1e1s1 2.4 101 sa 7.4 3146.86 321.89 870.03 1240886 2905 2906 76 1311 32023 219225 0sa8l 15202.045 4133.1 a5l.0 es1i1s 127:210 1515.506 35335 522.36 0118.41256 aos 79.7 145.8 23.2 25 83 29.0 A310552 1268.29 746..68 13-54..59 `CompanySanitized. Doesnot conTtSCaAiCnBI 9H0-2-4D7a6y8:GavSaubgeehrSotnuidcy iTnoxRiactistywithOne:Generation Reproductive Evaluations DuPon-5990 ~ INDIVIDUAL BODY WEIGHT GAINS (grams) OF P, FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY GEDSATYAST:ION 07 714 wer 021 ANIMAL NUMBER 646547 39.5 37.8 1153 192.6 664a6s6e0676a 763..99 1s4s9 111044 1809052 6s4a66650204 39tl3 po34 a979 J. 170.6 664466569448 2321030 s31sl2o 7es8l31 n16a1l0d5 6s4a6s5e4661a 26.5 2905 97.6 154.0 30.1 3.8 20 40.9 6a64g6s62711 2a7l.s8 22078s 4s7l1l a9s77l39 6a6ac6e5a9s0a 23210.85 a36s1 7346s 144336s 6465552 19.0 0.2 27 23 sas605a 34.2 a0 28 35.4 664a66651859a 21596 2950.36 si2l.27 11446.12 - 6644665624774 252.94 251025 009125 13180043 6466754 5.7 27 1s 6.5 ET `Company Sanitized. Doasnotcontain TSCA CBI H902-4D7a6y8:GavSaugbeehSrtoundiyc TinoxRiactistywith One- Generation Reproductive Evaluations DuPon-5990 - INDIVIDUAL BODY WEIGHT GAINS (grams) OF P; FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY GEaSTvAsT:ION 0-7 7-14 ue; on ANIMAL NUMBER 6as662 21.3 207 ses 109.8 664a666s28332 a307.8 l1a6s 3-8el9o 13282.32 646466563199 216605 3398011 7s4a7a 11430.a0 6466280 36.7 7.9 82 36. 6as6162 201 101 117 18.5 G6a4c6e5a6l32 257.6 1138s 32s3 a1l2.s7 66a4g6s51722 l35ea c2o1las 3-09l66 1ssl3a 646566 103 365 640 11008 6644666507202 2134a1 s28l1a 37478 11778.00s 664a6s6s58522 2s1sa5 276.89 915.59 12a052 6a6663d 2.4 e612 on --~ 6sa4s6e5a704e 2182a1 325.34 -e6e2l.s0 1288.15 646532 Jae 3200 sa 15103 Tio CompanySaniized. Doesnot conTtSaCAiCB--nI 'H9-02-4D7a6y8:GavSaubgeehSrtoundiyc TinoxRiactistywith One.Generation Reproductive Evaluations DuPont5990 APPENDIX REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS OF Py FEMALE RATS DURING LACTATION || | --E---- `Company Sanitized. Does not contain TSCA CBI 9102-4D7a6y8:GavSaubgcehSrtoundiyc TinoxRiactistywithOneGeneration Reproductive Evaluations - REPRODUCTIVE TOXICOLOGY DuPon-5990 INDIVIDUAL BODY WEIGHTS OF Py FEMALE RATS DURING LACTATION EXPLANATORY NOTES `Footnotes: a Nolitter was delivered; therefore no lactation data were collected. b No data due to weighing error. Al pups were found dead on Lactation Day 0. Data were excluded from statistical analysis. Abbreviations -- = NoData - ws CompanySanitized. Does not contain TSCA CBI 9H02.4D7a6y8:GaSvuabgeehrSotnuidcyTionxRiactistywith One.Generation Reproductive Evaluations Dupont:5990 - INDIVIDUAL BODY WEIGHTS (grams) OF 7, FEMALE RATS DURING LACTATION GROUP: 11-0 DOSE: 0 MG/KG/DAY . - LAaCTvAsT:ION ANTHAL NUMBER 6a64s665s735 ssiass6s282sa 6a6466552550 S8a4s6s5a0d3 664a6s660541 Gc4a6s6s025a s5a466559517 ssaassseaads ssaa51ss65652560490 sass68 0 712 336215..40 833588 a10i60 335775.095 3S 300 s 3932 4176 sees 336070.48 e 3683 2 438843 3346813s 3323320025 s35e1s7 3389037 2375000079 3S70b0 a3s8e1 wseez s3i1s9 3f09r2 2o97o9 3a329 313.7 33220020 333833 3300.14 333290s0 336788085 33876518 938123 336519.82 3r61e3 3e68e3 saems 36a8e.7 3396060090 3s9a3l7 43219903s 330251265 --- Cw `Company Sanitized. Donotecontsain TSCA GBI B902-4D7s6y8:GavSaubgcehrSotnuidcy TinoxRiactistywithOne Generation Reproductive Evaluations Dupont5990 - INDIVIDUAL BODY WEIGHTS (grams) OF Py FEMALE RATS DURING LACTATION Grou: 1v-0 DoSE: 25 MG/KG/DAY LTAaCTvAsTION 712 Anns omBER Gsaaesses3a0 33653.8 336s87.05 d37e5s.e7 33693.24 saSasssseora 36f 9.3 e 0 ele, 61a sa8s46s3n0a4a 3e5r2 wmne 3m6nt3 36m0m.6 sasse7a saceaia a pTee oteS 8844650239 332550000 3a5b90a5 33346840 333340.10 sa8s46s5s7a5a 305.1 32e3m.8 0.4 207.4 saSsa6se67a2a 3o 0 h 0 2 LD es sa6584a -- a TD sa84c6s3a936 sSabs 33291s 3j5a3a5 s34a1s - ssaassesrs0eaa oTwo sa6ss3 33.9 36.5 390.4 303.7 Te `CompanySanitized. DoesnotconTtSaCAiCn8 H9-02-4D7a6y8:GavSaubgeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont:5990 - INDIVIDUAL BODY WEIGHTS (grams) OF P, FEMALE RATS DURING LACTATION Group: VI-0 DOSE: 100 MG/XG/DAY. LADCATYAST:ION 712 ANIMAL NUMBER 646547 31 32.7 368.1 342.3 6s4a6s6606764 3--7.-2 3--713 3-789 37-5.3 6s4a666502042 32-0.6 35o5l.5 380l.L4 36l2L.2 664466569445 33a1i5l.s8 saeslss a35s1s8 336142..77 646545 31509 34001 365.6 352.4 6s4a6c6e7611a 32--1.8 32p3..0 33.8.0 35.0.0 646521 306.6 351.9 375.7 373.1 6644666549502 300l.L2 33l4L7 355l.L2 35_1l.6 6465554 6466050 oeie phpdt a--ne ---- 6644666518592 33.4.1 3181 30-4.0 34o8o.4 - 66a46665a2770 332l.L0 35o6e.4 _ 364.8 ol 344.0 6466752 -- - -l - - aw Company Sanitized.DoesnotconTtSaCAiC8n1 H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats withOne-Generation Reproductive Evaluations DuPont5990 INDIVIDUAL BODY WEIGHTS (grams) OF P; FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY. LADCATYAST:ION 712 ANIMAL NUMBER 646662 261.0 288.0 290.1 267.1 6s4a66652833a 33--5-.6 32--7.3 35--5.8 35C7o.3 664466563199 337155.143 3d7o3.l6 338591.s5 430366.073 ' 6466284 il lL = - sa6616a -- --- --- . 6saa6665a613a 31-6-.1 p36a807 37p6e..5 37.4.4 66a466551722 2207151038 2209960135 332070.045 332075..77 646566 28612 318ls 31813 31706 6644666507208 28p6y.5 314.9 30_9.8 29135.3 66a4666556522 309l.L4 325ol.5 3--3ls 30=3.0 6a6663 202.1 3118 3321 336.2 --_ 6466400 lL po ol Jo, 664a66553724 B303z.4 e36l0.e8 33030377 33375.33 - ow `Company Sanitized. Does not contain TSCA C81 H9-02-4D7a6y8G:avSaugbcehSrtoundiyc TinoxRiactistywith Ore-Generation Reproductive Evaluations DuPont:5990 APPENDIX T REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS OF P, FEMALE RATS DURING LACTATION - `Company Sanitized. Does not contain TSCA C81 H902.4D7a6y8G:avSaugbechSrtoundiyc TinorRiactistywith One-Generation Reproductive Evaluations - REPRODUCTIVE TOXICOLOGY DuPont 5990 INDIVIDUAL BODY WEIGHT GAINS OF P; FEMALE RATS DURING LACTATION EXPLANATORY NOTES Footnotes a Nolitter was delivered; therefore no lactation data were collected. b No data due to weighing error. All pups were founddeadon Lactation Day 0. Data were excluded from statistical analysis. Abbreviations = NoData Te `CompanySanitized.Doesnot conTtSaCAiGBnI 012-4D7a6y8;GavSsugbeehSrtouidcy TinoxRiactistywithOne Generation Reproducive Evaluations Dupont:5990 - INDIVIDUAL BODY WEIGHT GAINS (grams) OF P, FEMALE RATS DURING LACTATION Rove: 11-0 DOSE: 0 MG/KG/DAY LacaTvasT:on 07 7 wa oa: Anon wowpER sa6g46e5s7)5 29a0 wais 1Gsias 3w.a saS8sa4s6se5sz5s20a 2So aDalaa aeo, C--ass Gascass50236 1o0l2a a1s1l ealsol d1a8i4s GGaaccee0is 3261 020s C1a6ls s4iss csaaseesssLza o "buh ms a3 ib SGa4s6e5o?s d5is m3a0 2 ma aaas S8a4s6s5o4 BTloe 2Caals lslss as2h6 Saseas we wo as 73 saSsasss2e0s0 Jo ades mz 7a ~ SSaassseesns 2ep as 358 malrss ow1l3s --_---- `Company Sanitized. Doesnotcontain TSCA CBI H-24768: SubchronicToxicity '90-Day Gavage Study in Rats withOne-Generation Reproductive Evaluations DuPont:5990 - INDIVIDUAL BODY WEIGHT GAINS (grams) OF Py FEMALE RATS DURING LACTATION GROUP: 1V-0 DOSE: 25 MG/KG/DAY LDAACYTAST:ION 07 7-14 14-21 0-21 ANIMAL NUMBER 664466653589 32.27 87.26-2-6124.3 -124..46 6644665569182 --9.7 ---2-.6 See 20.5 -8.2 6644665507430 2e8e.4 3=7e.7 =8.e7 -57.4 6465872 -- --- --s ace 6644665623912 -1.-6 -8-.0 6-.-3 -0--.1 646603 349-11 6.0 29.0 6644665575943 = 18.7 6-.6 -5o3e.0 -o17e.7 6644666576240 -9e.0 -1-2 -1-2.4 e2.e2 6465842 --- -- -- -- 664466554936 -13.b5 215.146-1152080 2-6-.b9 - 6465582 -- -- -- --- 6644665657302 -3-.0 1-3.5 -8e6e.7 -o70e.2 1033+ Company Sanitized. Doesnot contain TSCA CBI F9-02-4D7a6y8:GavSaugbeehSrtoundiyc iTnoxRiactistywith One-Generaton Reproductive Evaluations DuPont-5990 INDIVIDUAL BODY WEIGHT GAINS (grams) OF Py FEWALE RATS DURING LACTATION GROUR: VI-0 DOSE: 100 MG/KG/DAY. LADCATYAST:ION 0-7 714 wen 02; ANIMAL NUMBER 646547 2.6 a6 25.8 a. 66a466666067a ---a1 ---76 3--- s -51 . 6644666502408 --30-.9 209 1-8l.2 3-7.6 . 664466569448 135208 11312 s18a9 2a208 646546 202 25s 132 36s 6s4a666676112 --1l2 1p5.0 1o2l.0 2jo8..2 646521 453 238 2.6 66.5 6s4a66654950a a-s 2-05 3--6 s-ia 6465552 -- - -l - 6a66054 6465892 p---l .-- --- e--e 646615 "160-41 ada 143 --- 6644666542772 .22.4 1l0o 04-2.08 1j2--.0 6a6675a ja -- -- p. - aw `Company Sanitized.Doesnot containTSCA CBI 24768: Subehronic Toxicity 90-Day Gavage Study in Rats with OneGeneration Reproductive Evaluations DuPont5990 - INDIVIDUAL BODY WEIGHT GAINS (grams) OF P, FEMALE RATS DURING LACTATION GROUP: VITI-0 DOSE: 500 MG/KG/DAY LDAACYTAST:ION 0-7 74 wz 0-2 ANTAL NOMBER 6a6662 27.0 31-40 26 6c4a5g6s2e3ra a---3 m--s --1s 2--1-7 664455563199 "Gal7s osllss 1a2s m1l0s Gas620a ------ cass16a --- --- --- --- 66aasss5d6L32 2-2-.6 -7-8 2--- a 2--a 6Ga4s6s517z2 235025 2840a1 a03s 51149s 646566 206 Sos 07 ala 6a64s65670022 wena 5-1 d-e-s -5--.-8 6acasg6ssesza 1o6l.1 -- ol So 60 285-6. 6ass63 197 2003 a1 ad ~ 6456402 --- -- --- -- 6aGa6g5s7342 330a2-2070a7 6166 3116s0 Ti0%-`CompanySaniized. -- DoesnotconTtSaCAiCnBI H9-02-4D7a6y8:GavSaugbcehSrtoundiyc iTnoxRiactistywithOne-Generation Reproductive Evaluations DuPont:5990 APPENDIX U REPRODUCTIVE TOXICOLOGY INDIVIDUAL DAILY FOOD CONSUMPTION BY P; FEMALE RATS --_ DURING GESTATION i036`Company Sanitized. Does not contain TSCA CBI H902-4D7a6y8;GavSaugbcehSrtoundiyc iTnorRiactistywith One-Generaion Reproductive Evaluations - REPRODUCTIVE TOXICOLOGY DuPont5990 INDIVIDUAL DAILY FOOD CONSUMPTION BY P; FEMALE RATS DURING GESTATION EXPLANATORY NOTES Footnotes: a Nolitter was delivered; data were excluded from statistical analysis. b No gestation data were collected since no copulation plug was observed; howevear liter was delivered. : No gestationdata were collected since no copulation plug was observed; no litter was delivered. d Start of gestation miscalculated; data were excluded from statistical analysis Nolitter observed; however, implantation sites were present at necropsy. Data were excluded from statistical analysis. Abbreviations -- = NoData T1037CompanySanitized.Doesnot conTtSaCAiCBnI H9-02-4D7a6y8:GavSaubgcehrSotnuidcy TinoxRiactistywithOne-Generation Reproductive Evaluations DuPont-5990 - INDIVIDUAL DAILY FOOD DCUORNISNUGMPGTEISOTNATI(gOrNams) BY P, FEMALE RATS GROUP: II-0 DOSE: 0 MG/KG/DAY GDESATYASTION 0-7 7-14 14-21 0-21 ANTAL NUMBER 664466567553 12960.51 3208..45 23915.30 2268..45 6644666528258 2251..80 2198.31 1270..00 2230..90 664466555206 222550s0 2276.11 2270..87 2275..16 646503 253 27.0 2700 26.4 66466660444 2--6-.5 2--7.5 2=8.2 2e6e.7 646651 24.9 2307 246 24.4 6644666505624 2191.81 22131s 2231.14 2230..04 664466559517 2244..59 22090.70 2298..35 2274.85 664466654464 22195059 23290.74 13031 2390.8 --_ 6644665562902 2261..10 2228..10 2291..57 2271..96 664466666584 2250.93 2275..44 2267..79 2265..79 _--m, `CompanySanitized. Doesnot contain TSCA CBI H9-02-4D7a6y8:GaSvuabgeehrSotnuidcy TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 - TNDIVIDUAL DAILY FOODDCUORNISNUGMPGTEISOTNATI(gOrNams) BY P, FEMALE RATS GrOv: 1-0 DOSE: 25 MG/KG/DAY GEDSATYAST:ION 07 71 wen om; ANIMAL NUMBER 664466565398 22551.54 2305.060 23920.03 22690.54 . 664a66556918a 22270.70 227675 2253.0 2261.01 : 6644665507838 a27l.s4 222802s 220338 22260.96 6465872 1905 19.9 18.4 19.3 6644665623918 2253.34 228576 2267.80 22550.67 646603 56 2a6 201 19.4 6644665575942 2205.16s 221632 2126.20 2168030 6644666576244 22143 220001 1380.25 1298.99 s64a6s55483a2 262.26 2347.36 2180.05 268.s6 - 6644665595682 223.098 2250515 2260020 251 21 6644665657302 23:s8 2179074 3200s1 2209.99 "ios -- CompanySanitized. Dos notconTtSaCAiC8n1 9H0-2-4D7a6y8:GavSaugbcehSrtounidcy TinoxRiactistywith One-Generation Reproductive Evaluations DuPont. 5990 - INDIVIDUAL DAILY FOOD DCUORNISNUGMPGTEISOTNATI(gOrNams) BY P, FEMALE RATS GROUP: VI-0) DOSE: 100 MG/KG/DAY. GeDsATYaST:ION 0-7 7-14 wn 021 ANIMAL NUMBER 646547 28.7 311 36.0 32.0 64sa6c6e0676a 22900.20 22820.76 324500 3230..97 6644666502040 2=61 2p6y.6 2--3 2o7o.0 664a6c56944n 2252a 222846 323033 229310 646546 182 24s 280 2306 6saac6e66711a 2265.63 221357 22930.51 2z1.a5 6ags21 2313 238 203 238 66a4c665a9s02 22021.38 225015 2197.s9 22520.65 6a6s552 27.3 253 180 235 6466052 26.0 262 200 20.1 - 6644666518592 2102s 2210.16 235122 221..28 6644666542772 2222016 2230014 27060 210178 6466752 2006 22.8 23.3 22.2 --- Tiot0- `CompanySanitized. Does notconTtSaCAiCBnI 9H-02.4D7a6y8:GavSaubgcehSrotnuidcy TinoxRiactistywith One-Generaion Reproductive Evaluations DuPont 5990 - INDIVIDUAL DAILY FOODDCUORNISNUGMPGTEISOTNATI(gOrNams) BY P, FEMALE RATS GROUP: VITI-0 DOSE: 500 MG/KG/DAY GDEASTYASTION 07 714 ue on ANIMAL NUMBER 6aces2 sagsaIa 18.3 21.0 213 235 220.089 2210..88 . 6e4a6s6e1253 2275010s 3208ss 3228074 32010.16 s6a466652389a 217 28a 18ls 2200 25.5 26.4 24.3 25.4 6466162 25.3 a8 230 11.0 6saa666546132 22621.59 2227..34 33260.36 2218.72 664466557122 223710 22047 2am7o 2z1as 646566 isle 25s 286 24.3 6644666507202 2175.69 2250.28 2276.55 2261.s3 664a66655652a 1199033 2251064 2290007 220438 - 6466634 20.9 203 --- -- 6sa4s665a704e 2256.85 321823 130s.0 2219.039 6a6532 2604 314 385 3007 Tio-`CompanySanitized. Doesnot conTtSaCAiCBnI H-24768; Subchronic 90-Day Gavag Study Toxicity in Rats with One-Generation Reproductive Evaluations DuPont:5990 APPENDIX V REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS IN P MALE RATS - we Company Sanitized. Does not contain TSCA CBI H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats with One.Generation Reproductive Evaluations DuPont-5990 - INDIVIDUAL CLINICAL OBSERVATIONS IN Py MALE RATS GROUP: 1-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFBISRESTRVEDDAY OLABSSTERDVAEYD 646450 646440 646a2e 646402 646392 646473 646395 646352 646357 646409 646328 646479 646470 S0ACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 102 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 102 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 102 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 102 NSOACARBINFOIRCMEADLIBYTIEDSESDIEGTNECTTEESDT DAY 102 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 103 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 103 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 103 DDIISSCCHHAARRGGEE NMOOSUETHRERDED SACRIFICED BY DESIGN TEST DAY 103 ASLAOCPREICFIIACEDRIBGYHTDEFSRIOGNNT LTEEGS(TS)DAY 103 NSOACARBINFOIRCMEADLIBYTIEDSESDIGENTECTTEESDT DAY 104 NSOACARBINFOIRCMEADLIBYTIEDSESDIGENTETCETSETD DAY 104 NSOACARBINFOIRCMEADLIBYTIEDSESDIGENTETCETSETD DAY 104 7788 9788 8s 103 "ioe `CompanySanitized.Dossnot containTSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 - INDIVIDUAL CLINICAL OBSERVATIONS IN P, MALE RATS GROUP: I-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER ossERVATION OFBISRESTRVDEADY OLBASSETRVDEADY 6a6a61 SNAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 104 646480 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 104 646383 SNAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 105 646405 SNAOCARBINFOIRCMEADLIBTYIEDSESIDEGTNETCETSETD DAY 105 646358 SNAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 105 646425 SDTIASICNHEADRGREIGEYHET(SE)YE(RSE)D BROWN SACRIFICED BY DESIGN TEST DAY 105 - 646408 SNAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 105 : 98 18s 10wCompany Sanitized. Does not contain TSCA CBI 9H0--2D47a6y8G:avSaubgcehSrtoundiyc iTnoxRiactistywithOneGeneration Reproductive Evaluations DuPont-5990 - INDIVIDUAL CLINICAL OBSERVATIONS IN Py MALE RATS GROUP: TIT-0 DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFIBRSSETRVDEADY OLBASSETRVDEADY 646378 sagas 646363 546334 646493 646404 sa6a1s 646410 646380 646350 646467 646361 646312 NSOACARBINFOIRCMEADLIBYTIEDSESDIGENTETCETSETD DAY 102 NSAOCRAIBFNOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 102 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 102 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 102 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 102 SSAALCIRVIAFTIICOEND BY DESIGN TEST DAY 103 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNETCETSETD DAY 103 NSOACARBINFOIRCMEADLIBYTIEDSESDIEGTNETCETSETD DAY 103 NSOACARBINFOIRCMEADLIBYTIEDSESDIGENTETCETSETD DAY 103 NSOACARBINFOIRCMEADLIBTYIEDSESDIGENTECTTEESDT DAY 103 NSOACRAIBFNOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 103 SSAALLITVVAATTIIOONN SSAACLRIIVFAITCIEODN BY DESIGN TEST DAY 104 SSAALCIRVIAFTIICOEND BY DESIGN TEST DAY 104 9s 95 895 9859 100 100 100 100 Tos CompanySanitized. DoesnotcontTSaCAiCnBI H24768:Subchroric Toxicity 90-Day Gavage Study in Ras withOne-Generation Reproductive Evaluations DuPont5990 - INDIVIDUAL CLINICAL OBSERVATIONS IN P, MALE RATS GROUP: III-0 DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFBISRESTRVEDDAY OLBASSTERVDEADY 646450 646326 646377 646478 646350 646333 sagas NSOACRAIBFNOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 104 SSAACLRIIVFAITCIEODN BY DESIGN TEST DAY 104 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 105 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 105 SALAOCPREICFIIACEBDOTBHY DFREOSNITGNLETGE(SST) DAY 105 SSAALCIRVIAFTIICOEND BY DESIGN TEST DAY 105 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 105 100 100 8a 105 100 100 - ws `Company Sanitized. Doesnot contain TSCA CBI H9-02-4D7a6y8G:avSaubgcehSrtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 - INDIVIDUAL CLINICAL OBSERVATIONS IN Py MALE RATS GROUP: V-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFBISRESTRVEDDAY LOABSSTERDVAEYD 646353 SSAALCTRVIAFTIICOEND BY DESIGN TEST DAY 102 646341 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT LBEAGW((SS)) SSAALCTRVIAFTIICOEND BY DESIGN TEST DAY 102 646356 NSOACARBINFOIRCMEADLIBYTIEDSESDIEGTNETCETSETD DAY 102 646330 SSAALLIIVVAATTIIOONN SACRIFICED BY DESIGN TEST DAY 102 646499 AALLOOPPEECCIIAA BROITGHHTFFRROONNTTLEPGA(WS()S) SACRIFICED BY DESIGN TEST DAY 102 _ 646400 ASLAOCPREIFCIICAEDBOTBHY DFERSOINGTNPTAWE(SST) DAY 103 646417 SSAALCTRVIAFTIICOEND BY DESIGN TEST DAY 103 646338 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 103 pr SSAALLITVVAATTIIOONN SASLATCRVIAFTIICOEND BY DESIGN TEST DAY 103 646387 SSAALCTRVIAFTITCOEND BY DESIGN TEST DAY 103 646447 NSAOCRAIBFNOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 104 100 100 88a3 110022 00 . 100 10910 10910 88aa 110022 8s 103 100 100 729 9960 100 102 101 101 ioe CompanySanitized. Doesnot containTSCA CB H9-02-4D7a6y8:GaSvuabgcehrSotnuidcyTionxRiactistywithOne Generation Reproductive Evaluations DuPont-5990 - INDIVIDUAL CLINICAL OBSERVATIONS IN Py MALE RATS GROUP: V-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFIBRSSETRVDEADY OLBASSTERVDEADY 646336 SSAALLITVVAATTIIOONN SACRIFICED BY DESIGN TEST DAY 104 646366 SSAALCIRVIAFITCIEODN BY DESIGN TEST DAY 104 646496 SSAACLRTIVFAITCIEODN BY DESIGN TEST DAY 104 646375 SSAALCIRVIAFTIICOEND BY DESIGN TEST DAY 104 646465 SSAALCTRVIAFTIICOEND BY DESIGN TEST DAY 105 646390 SSAALCIRVIAFTIICOEND BY DESIGN TEST DAY 105 - 646429 SSAALLTIVVAATTIIOONN SACRIFICED BY DESIGN TEST DAY 105 646476 SSAALCTRVIAFTITCOEND BY DESIGN TEST DAY 105 sa63a8 SSAALLTTVVAATTIIOONN SACRIFICED BY DESIGN TEST DAY 105 10809 10805 8s 85 8s 8 96 99 8 8 02 95 10811 10915 89 01 8939 8599 iow `Company Sanitized.Dossnotcontain TSCA CBI H9-02-4D7a6y8G:avSaugbecShrtoundiyc iTnoxRiactistywith OneGeneration Reproductive Evaluations. DuPont5990 - INDIVIDUAL CLINICAL OBSERVATIONS IN P, MALE RATS GROUP: VII-0 DOSE: 500 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFBISRESRTVEDDAY LOABSSTERVDEADY sa6382 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCTEESDT DAY 102 646406 SSAALCIRVIAFTIICOEND BY DESIGN TEST DAY 102 646491 SSAALCTRVIAFTITCOEND BY DESIGN TEST DAY 102 646351 SSAALCTRVIAFTIICOEND BY DESIGN TEST DAY 102 646405 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 102 sa6a18 SSAALCIRVIAFTIICOEND BY DESIGN TEST DAY 103 sa6362 AALLOOPPEECCIIAA IPNEGRUIENNEUM --_ SSAALCIRVIAFTIICOEND BY DESIGN TEST DAY 103 646497 SSTTAAIINNEEDD IPNEGRUIENNEUYMELYLEOLWLOW SSSAAACLLRTIIVVFAAITTCIIEOODNN BY DESIGN TEST DAY 103 sa6401 SSAALLIIVVAATTIIOONN SACRIFICED BY DESIGN TEST DAY 103 646498. AALLOOPPEECCIIAA RRIIGGHHTT FFRROONNTT LPEAGW((SS)) AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT LPEAGW((SS)) SSATCARIINFEIDCEPDERBIYNEUDMESIYGENLLOTWEST DAY 103 9 9 9 9 7 100 99 9 811 110033 81 84 7788 9968 9%78 9862 7028 1082s s8a4 884a 9a11 110033 98 103 - aw CompanySanitized. Doesnot conTtSaCAiCBnI H-24768:Subchronic Toxicity 90-Day Gavage StudyinRats with One-Generation Reproductive Evaluations DuPont-5990 - INDIVIDUAL CLINICAL OBSERVATIONS IN Py MALE RATS GROUP: VII-0 DOSE: 500 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFBISRESRTVEDDAY OLBASSETRDVAEYD 646386 SSAALLIIVVAATTIIOONN SSATCARIINFEDICEPDERBIYNEUDMESIYGENLLOTWEST DAY 104 10829 10829 108 10a 616332 SSAALLIIVVAATTIIOONN . SSAALLIIVVAATTIIOONN SACRIFICED BY DESIGN TEST DAY 104 8500 8500 995 9955 6a6aa1 SSAALLITVVAATTIIOONN SACRIFICED BY DESIGN TEST DAY 104 8958 10829 6a6as2 SSAALLITVVAATTIIOONN SSAALCTRVIAFTIICOEND BY DESIGN TEST DAY 104 8552 8825 95 95 - 646365 SSTAACIRNIEFDICEPDERBIYNEUDMESIYGENLLTOEWST DAY 104 a1 108 646393 SSAALLTTVVAATTIIOONN SACRIFICED BY DESIGN TEST DAY 105 5922 8928 646359 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT PLAEWG((SS)) SSAALLTTVVAATTIIOONN SSAALCIRVIAFTIICOEND BY DESIGN TEST DAY 105 88a4 10950 8542 990 5 104 sa6as1 SSAALLITVVAATTIIOONN SSAALCTRVIAFTIICOEND BY DESIGN TEST DAY 105 899 8996 100 100 EE Company Sanitized. Does not contain TSCA CBI HL24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generaton Reproductive Exaluations DuPont5990 APPENDIX W REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS IN P, FEMALE RATS -- DURING GESTATION - we Company Sanitized. Doos not contain TSCA CBI H-24766: Subchronic Toxicity 90-Day Gavage Study in Rats with OneGeneration Reproductive Evaluations - REPRODUCTIVE TOXICOLOGY DuPont:5990 INDIVIDUAL CLINICAL OBSERVATIONS IN P, FEMALE RATS DURING GESTATION Note EXPLANATORY NOTES "This appendix includes only clinical observations from rats with copulation plug observed. Footnotes a Copulation plug observed but no litter delivered. b Deliveredalitter on Day 16G. es `Company Sanitized. Does not contain TSCA CBI 'H9-02-4D7a6y8G:avSaugbeehSrtoundiyc iTnoxRiactistywithOne-Generation Reproductive Evaluations DuPont5990 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN P, FEMALE RATS DURING GESTATION GROUP: II-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION, OFBISRESTRVEDDAY OLABSSTERDVAEYD 646653 DISCHARGE LEFT EVE(S) RED 646575 NO ABNORMALITIES DETECTED 6465852 NO ABNORMALITIES DETECTED sa6622 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT LPEAGW((SS)) 646550 NO ABNORMALITIES DETECTED 646526 NO ABNORMALITIES DETECTED 646503 NO ABNORMALITIES DETECTED 646608 NO ABNORMALITIES DETECTED 6a6651 NO ABNORMALITIES DETECTED 6465524 NO ABNORMALITIES DETECTED -_ 646606 AALLOOPPEECCIIAA LBOETFHT FFRROONNTT LLEEGG((SS)) 646557 NO ABNORMALITIES DETECTED 646591 ALOPECIA BACK sa6540 NO ABNORMALITIES DETECTED 6aseas NO ABNORMALITIES DETECTED 6465202 NO ABNORMALITIES DETECTED 646569 NO ABNORMALITIES DETECTED 646654 NO ABNORMALITIES DETECTED 646668 NO ABNORMALITIES DETECTED 7 2 0 2211 o2 20 o 7 | - aw Company Sanitized.Does notconTtSaCAiCBnI H9-02-4D7a6y8:GSauvbacgherSotnuidcyTionxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 _ INDIVIDUAL CLINICAL OBSERVATIONS IN P; FEMALE RATS DURING GESTATION GROUP: IV-0 DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFIBRSSETRVEDDAY OLBASSETRVDEADY 646638 NO ABNORMALITIES DETECTED 646559 NO ABNORMALITIES DETECTED 6465984 STAINED PERINEUM YELLOW `sags61 NO ABNORMALITIES DETECTED 6465738 NO ABNORMALITIES DETECTED 646504 ALOPECIA BOTH FRONT BAW(S) 6465872 NO ABNORMALITIES DETECTED 6466318 AALLOOPPEECCIIAA RRIIGGHHTT FFRROONNTT LPEAGW((SS)) 646529 NO ABNORMALITIES DETECTED 646603 ALOPECIA BOTH FRONT PAW(S) - 6465504 NO ABNORMALITIES DETECTED 646579 NO ABNORMALITIES DETECTED 6465642 NO ABNORMALITIES DETECTED 646672 NO ABNORMALITIES DETECTED 6465842 NO ABNORMALITIES DETECTED 646543 NO ABNORMALITIES DETECTED 646596 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT LPEAGW((SS)) ALOPECIA RIGHT SIDE(S) 6465582 NO ABNORMALITIES DETECTED o o 2 2 0o 221 0 2 00 221 21 21 - ae Company Sanitized. Does not contain TSCA CBI H9-02-4D7a6y8:GaSvuabgcehrSotnuidcy iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont5990 -- INDIVIDUAL CLINICAL OBSERVATIONS IN Py FEWALE RATS DURING GESTATION GROUP: IV-0 DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFIBRSSETRVDEADY OLBASSETRVDEADY 6466704 6a6ss3 SATLAOIPNEECDIAPEBORTIHNEUFMROYNETLLLOEGW(S) ALOPECIA BOTH FRONT BAW(S) AALLOOPPEECCIIAA RRIIGGHHTT FFRROONNTT PLAEWG((SS)) ALOPECIA BOTH FRONT PAW(S) 7 27 18 21 o0 11sa : 18 21 -- TT0ss- -- CompanySanitized. DoesnotconTtSaCAiCanl F9-02-4D7a6y8G:aSvuabgcehrSotruidcy TinoxRiactistywithOne:Generation Reproductive Evaluations DuPont-5990 --- INDIVIDUAL CLINICAL OBSERVATIONS IN Py FEMALE RATS DURING GESTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFBISRESTRVEDDAY OLBASSETRVDAEYD 646547 SALTVATION 6466662 NO ABNORMALITIES DETECTED 646607 SALTVATTON 646600 SALTVATION 6a66as SSAALLITVVAATTIIOONN 646590 NO ABNORMALITIES DETECTED 646546 AALLOOPPEECCTIAA RBOITGHHTHISNIDDE(QSU)ARTERS 6466614 646671 SALTVATION STAINED PERINEUM BROWN _ 6a6521 ALOPECTA BOTH FRONT LEG(S) 6465908 SSAALLIVVAATTIIOONN 6a66as NO ABNORMALITIES DETECTED 6465554 NO ABNORMALITIES DETECTED 6466058 SSAALLIIVVAATTIIOONN 6465854 SALVATION 646615 SAALLOTPVEACTIIAONBOTH HIND QUARTERS 6465272 NO ABNORMALITIES DETECTED 646647 NO ABNORMALITIES DETECTED 6466752 NO ABNORMALITIES DETECTED 2 27 4 4 6 7 185 185 1188 2211 15 15 1 1 o 2 155 185 165 165 16 16 14 217 "10%. `CompanySanitized. Does notcontainTSCA CBI 'H9204-7Da6y8:GavSaubgcehSrtoundiyc TinoxRiactistywith OneGeneration Reproductive Evaluations DuPon5990 -- INDIVIDUAL CLINICAL OBSERVATIONS IN P, FEMALE RATS DURING GESTATION GROUP: VIIT-0 DOSE: 500 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFBISRESTRVEDDAY LOABSSTERDVAEYD 646662 SALIVATION 6465838 NO ABNORMALITIES DETECTED 646623 SALTVATION 646619 NO ABNORMALITIES DETECTED 646539 NO ABNORMALITIES DETECTED 6466288 SSTAALIINVEADTIOPNERINEUM YELLOW 6466168 SALTVATION 6465638 6as6a1 SSAALLIIVVAATTIIOONN NO ABNORMALITIES DETECTED - 6a6572 AALLOOPPEECCITAA ACBHDEOSMTEN AALLOOPPEECCTIAA UBONTDHERBHOIDNYD QUARTERS ALOPECTA BOTH SIDE(S) 6a6512 AALLOOPPEECCTTAA BABODTOHMERNEAR LEG(S) AALLOOPPEECCITAA BPOETRHINEHUIMND QUARTERS AALLOOPPEECCIIAA BBOOTTHH FSIRDOEN(TS)LEG(S) 6a6s66 NO ABNORMALITIES DETECTED 6465708 AALLOOPPEECCITAA RBOITGHHTFRSOIDNET(SP)AW(S) ALOPECIA ABDOMEN 6 6 16 nv . 1158 119 5 n 1165 116 0 77 114 221 18 21 00 2211 o7 2211 11 2211 1188 21 2 21 2 - aw CompanySanitized.Doesnot conTtSaCAiC8n1 H902-4D7a6y8:GaSvuabgeehrSotnuidcy TinoxRiactistywithOne.Generation Reproductive Evaluations DuPont:5990 _ INDIVIDUAL CLINICAL OBSERVATIONS IN P, FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFIBRSSETRVDEADY OLBASSETRVDEADY 646602 AALLOOPPEECCIIAA BABODTOHMEHNIND QUARTERS SAALLOIPVEACTIIAONLEFTSHOULDER(S) SALIVATION 6465828 STAINED PERINEUM YELLOW 6a6655 ASLTOAPIENCEIDAPBEORTIHNEUFMROYNETLLBOAWW(S) 6466630 SSATLAIIVNAETDIOPNERINEUM YELLOW 6466402 SCTOALIONREEDD DPIESRCIHNAERUMGEYVEALGLIOWNAL OPENING RED SSTTAAIINNEEDD CVAAGGIENBAOLARODPERNEIDNG BROWN COLORED DISCHARGE VAGINAL OPENING RED _ 646570 AALLOOPPEECCTIAA BROITGHHTHIHNIDNDQUQAURATRETRESRS ALOPECIA PERINEUM 646532 AALLOOPPEECCTIAA UBNODTEHRBHOIDNYD. QUARTERS AALLOOPPEECCIIAA BBOOTTHH SFIRDOEN(TS)LEG(S) ALOPECIA BOTH FRONT BAW(S) 0 221 4 214 15 pt 2 70 180 1o 140 16o 1166 1168 1168 2 21 149 27 14 21 00 221 00 221 o 2 Te Company Sanitized. Does notcontainTSCA CBI H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generaton Reproductive Evaluations DuPont5990 APPENDIX X REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS IN P, FEMALE RATS - DURING LACTATION Te Company Sanitized. Doesnotcontain TSCA Cal 9H0-2-4D7a6y8:GavSaugbechSotniyc TinoxRiactistywith OneGeneration Reproductive Evaluations DuPont5990 - REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS IN Py FEMALE RATS DURING LACTATION EXPLANATORY NOTES Note "This appendix includes clinical observations from lactating rats only. Footnote : a No copulation plug was observed, however, a liter was delivered. --_-- Tw `Company Saniized. Does not contain TSCA CBI | H24768: Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN P, FEMALE RATS DURING LACTATION GROUP: II-0 DOSE: 0 MG/KG/DAY ANIMAL NOMBER OBSERVATION OFBISRESRTVEDDAY LOABSSTERDVAEYD 646653 DSTIASICNHEADRGLEELFETFTBYEE(YSE)(S)BRORWEND SACRIFICED BY DESIGN TEST DAY 119 646575 SNOACARBINFOIRCMEADLIBYTIEDSESDIEGTNETCETSETD DAY 119 616622 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT LPEAGW((SS)) SACRIFICED BY DESIGN TEST DAY 125 546550 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 127 6a6526 SNAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 118 646503 SNAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 118 - 6466442 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 117 646604 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 122 646651 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 118 646606 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT LBEAGW((SS)) SACRIFICED BY DESIGN TEST DAY 119 646557 NSOACARBINFOIRCMEADLIBYTIEDSESDIEGTNECTTEESDT DAY 120 646591 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 120 sa6540 NSOACARBIFNIOCREMDALIBTYIEDSESDIEGTNETCETSETD DAY 118 21o 2114 o0 27 7 2211 - we Company Sanitized. Does not contain TSCA CBI F9-02-4D7a6y8G:avSaubgcehSvtourdiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 -~ INDIVIDUAL CLINICAL OBSERVATIONS IN Py FEWALE RATS DURING LACTATION GROUP: II-0 DOSE: 0 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFBISRESTRVEDDAY OLBASSETRDVAEYD 646646 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNETCETSETD DAY 118 646569 NSAOCRAIBFNIOCREMADLIBYTIEDSESIDGENTETCETSETD DAY 120 646650 NSAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 120 : 6a6668 SNAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 120 -ae `Company Sanitized. Doesnot containTSCA C81 H-24768: Subehronic Toxicity 90-Day Gavage StudyinRats withOne-Generation Reproductive Evaluations DuPont5990 - INDIVIDUAL CLINICAL OBSERVATIONS IN P, FEMALE RATS DURING LACTATION GROUP: TV-0 DOSE: 25 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFIBRSSETRVDEADY OLABSSTERDVAEYD 646638 NSAOCRAIBFNIOCREMADLIBYTIEDSESDIGENTETCETSETD DAY 118 6a6s59 NSAOCRAIBFNIOCREMADLIBYTIEDSESDIEGTNETCETSETD DAY 118 646561 NSOACARBINFOIRCMEADLIBYTIEDSESDIGENTETCETSETD DAY 118 646504 ASLAOCPREICFIIACEBDOTBHY FDREOSNITGNPTAWE(SST) DAY 118 646529 NSOACARBINFOIRCMEADLIBYTIEDSESDIGENTETCETSETD DAY 118 646603 SALAOCPREICFIIACEDBOBTYH DFREOSNITGNDTAWE(SST) DAY 119 646579 NSAOCRAIBFNOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 117 646672 MSAASCSRIF1ICE2D.0BYcmDELSEIFGTN TSEHSOTULDDEARY(S1)19 646503 NSAOCRAIBFNOIRCMEADLIBTYIEDSESIDGENTETCETESDT DAY 118 646596 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT LPEAGW((SS)) AALLOOPPEECCIIAA RRIIGGHHTT SRIEDAER(SL)EG(S) SACRIFICED BY DESIGN TEST DAY 118 6agss3 AALLOOPPEECCITAA BBOOTTHH FFRROONNTT LPEAGW((SS)) SACRIFICED BY DESIGN TEST DAY 122 o 2 o 21 2 2 00 22 70 2o 21o 22 - ae__ Company Sanitized.Doesnot containTSCA C81 H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats withOne.Generation Reproductive Evaluations DuPont5990 INDIVIDUAL CLINICAL OBSERVATIONS IN Py FEWALE RATS DURING LACTATION GROUP: VI-0 DOSE: 100 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFIBRSSETRVEDDAY OLBASSETRVDEADY 646547 NSOACARBINFOIRCMEADLIBYTIEDSESDIEGTNETCETSETD DAY 120 646607 NSOACARBINFOIRCMEADLIBYTIEDSESDIEGTNETCETSETD DAY 120 646600 NSOACARBINFOIRCMEADLIBYTIEDSESDIGENTETCETSETD DAY 118 saseas NSOACARBINFOIRCMEADLIBYTIEDSESDIEGTNETCETSETD DAY 117 646594 NSOACARBINFOIRCMEADLIBYTIEDSESDIEGTNETCETSETD DAY 118 646546 AALLOOPPEECCIIAA BROITGHHTHSIINDDE(QSU)ARTERS SACRIFICED BY DESIGN TEST DAY 118 - 646671 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 121 646521 AALLOOPPEECCIIAA BBOOTTHH FRERAORNTLELGE(GS()S) ASLAOCPREICFIIACEDLEBFYT DSEIDSEI(GSN) TEST DAY 121 646645 SNAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 118 646615 AALLOOPPEECCIIAA ABBODTOHMEHNIND QUARTERS SSAALCIRVIAFTIICOEND BY DESIGN TEST DAY 121 646647 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNETCETSETD DAY 124 o0 22 00 221 1 2 0 25 5- 5 -we Company Sanitized. Does not contain TSCA CBI H-24768:SubchronicToxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5990 - INDIVIDUAL CLINICAL OBSERVATIONS IN Py FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFIBRSSETRVDEADY OLBASSTERVDEADY sa6662 SNAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 119 646623 NSAOCRAIBFNIOCREMDALIBTYIEDSESIDGENTETCETSETD DAY 118 646619 SNAOCARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 118 646539 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 118 646641 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 118 616572 AALLOOPPEECCIIAA UBONTDHERBHOIDNYD QUARTERS ASLAOCPREIFCIICAEDBOTBHY DSIEDSEI(GSN) TEST DAY 118 - sa6512 AALLOOPPEECCIIAA ABBODTHOMERNEAR LEG(S) AALLOOPPEECCIIAA BPOETRHINEHUIMND QUARTERS AALLOOPPEECCIIAA BBOOTTHH FSIRDOEN(TS)LEG(S) SACRIFICED BY DESIGN TEST DAY 117 646566 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 119 sa6602 AALLOOPPEECCIIAA BAOBTDHOMHEINND QUARTERS ASLTOAPIENCEIDAPLEERFITNEUSNHOUYLEDLELRO(WS) SACRIFICED BY DESIGN TEST DAY 119 646655 SSTAACIRNIEFDICEPDERIBNYEUDMESIYGENLLTOEWST DAY 121 00 2211 21 o0 221 o0 22 00 221 00 221 20 22 0 7 T1065 `CompanySanitized. Doesnot contain TSCA C8l 9H0--24D7a6y8G:avSaugbeehSrtoundiyc TinoxRiactistywith One-Generation Reproductive Evaluations DuPont-5990 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN P, FEVALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY ANIMAL NUMBER OBSERVATION OFIBRSSETRVDEADY OLABSSTERVDEADY 646663 `SCAOCLROIRFEIDCEDDISCBHYARDGEESIVGANGITNEASLT ODAPYENI1N21G RED 646532 AALLOOPPEECCIIAA UBNODTHERBHOIDNYD QUARTERS AALLOOPPEECCIIAA BBOOTTHH SFIRDOEN(TS)LEG(S) ASLAOCPREICFIIACEDBOBTYH FDREOSNITGNBTAWE(SST) DAY 122 0 o0 2211 00 221 0 2 "1066 CompanySanitized. Does not containTSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Sudy in Rats with One-Generation Reproductive Exaluations DuPon-5990 APPENDIX Y INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION INP, FEMALE RATS ee Company Sanitized. Doos not contain TSCA CBI H9-02-4D7a6y8;GavSaubgcehSrtoundiyc iTnoxRiactistywithOneGeneration Reproductive Evaluations DuPont-5990 - INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION INP, FEMALE RATS EXPLANATORY NOTES Footnotes: a Copulation plug detected, but animal did not delivear litter. b Mean cycle length was not calculable due to insufficient data No evidenceofcopulation from group summary data. was found; but animal di.d deliveralitter. Animal was excluded d No precoital interval cobeucalcluladted since no evidence ofcopulation was found. No evidenceofcopulation was found; animal did not deliver liter. J Animal delivereadlitteron Day 16G. Animal was excluded from statistical analyses. Abbreviations: -- = NoDuta -- Tm. -- Company Sanitized. Doesnot contain TSCA CBI 9H0--2D47a6y8G:avSaubgeehSrtoundiyc iTnoxRiactistywith OneGeneration Reproductive Evaluations DuPont 5990 INDIVDIUDRUIANLG APNRIEMMAALTIENSGTRAONUDS CCOYHCALBEITPAATRIAOMNETERS GROUP II-0: 0 MG/KG/DAY WoaErsRoFOF penocFevt pmcmwr pm oF oF MEA cree pRecormau ANUNMIBNELR COLLDEACATION DAYS IN ESTRUS DAYS IN DIESTRUS DAYS IN PROBSTRUS LENGTH (days) INTERVAL (days) 66aa66567s53 222 3263%% s5a9e% s 55 aa.lso 22 6465650 2 Ga6622 29 33% ED 148 79% os a0 1 7 s.s0 5 646550 30 53% ase 3 p10 646526 2 s28 33 usp 1 6sa4s665a043c 2315 21098% 67478% u6v 450303 a1 66a466665014 2261 22388 7696%8 088 a4.000 15 6aes52a 21 338 57% 108 400 1 664a6g6s0s67 2233 222288 6758%% 1o3vs a4l.o0o0 33 664466559410 2212 12050%8 saX)% v0s allps 1a ~ 6c4a6e6s4260a 2262 22378% 6793%8 asws aal0o 25 546466566594 2244 2393%8 5s8a8y B8y a4l.o0o0 aa 646668 23 224 700 9% slo0 3 T1069- -- Company Sanitized. Doesnot contain TSCA C81 H-24768: SubehronicToxicity 90-Day Gavage Study in Rats withOne-Generation Reproductive Evaluations DuPont:5990 INDIVDIUDRUIANLG APNRIEMMAALTIENSGTRAONUDS CCOYHCALBEITPAATRIAOMNETERS GROUP 1-0: 25 MG/KG/DAY WaovGEsRoFor ERocFEV pmoFcmv ECoFE cMvcEe eRacormu ANNUIMMBAELR COLLDEACATION DEASYTSRUISN DAYS IN DIESTRUS DAYS IN PROESTRUS LENGTH (dave) INTERVAL (days) 664466565358 2212 33328e 65298% s5%% a5..0000 21 6s4a665s6918a 2311 25548% 372188 Dssy ae 1 a3 1 6644665507832 221 2B3i%s 713488 ss lb 1 st a.00 2 6sa466653817a2 2216 2230%8 7537%%, wam s6o3s3 2 5 664466562093 22 2938 86288v. 99% aal7oo 23 6644665557094 223 3T3a%s a8s3s% 3% sls 5 198 4.00 1 s64a66657624a 2226 1194%8 7693%% w12e8 35.70s0 6 2 - s64a66554834a 22 925508. 13%) @sb a0 4 1 664a665595664 222 22388 55798 1189%% 5s.l0o0 21 6644665657308 2262 12878% 66588% u8e a5.5000 3 5 Too `CompanySanitized. Doesnot contain TSCA CBI H9-02-4D7a6y8G:avSaugbecShrtoundiyciTnoRxaitciswtyithOne-Generation Reproductive Evaluations DuPont-5990 INDIVDIUDRUIANLG APNRIEMMAALTIENSGTRAONUDS CCOYHCALBEITPAATRIAOMNETERS GROUP VI-0: 100 MG/KG/DAY To T mm owso op r vmcoFmw pomromn mCEN oF WcrEoAie emscorau pe NOMBER DATA COLLECTION DAVS IN ESTRUS DAYS IN _DIESTRUS DAYS IN PROBSTRUS LENGTH (dave) INTERVAL (days) scaac6e5s4s7a 22 2291%s S7858% Bawe 34.6500 44 64sa6e6s0z7ae 233s 2s2e8t 734088 souw aese a3 664466660408 2212 1297%8 76188% 1s0e8 a5lo0s0 21 664466559446 2222 322788 6648%% o9n% a4.s00 22 sa66614 20 508 ass 58 6.00 1 664466562711 223a 22598% 771%% awaasloo 44 6465908 21 646645 21 3% 57% 38% 57% ossr 86.0000 11 6465554 21 100% ) 6466054 21 108 sot w oop 11 --_ 6644666518592 2240 325188 a7s1e% 2800 54..0000 41 6465274 2a 250 75% os as 4 s64a6c6e4r7sa 2267 32688% 76088 1a5% 4s.o5o0 76 "ion -- `Company Sanitized. Does not contain TSCA C81 H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats with OneGeneration Reproductive Evaluations DuPon-5990 INDIVDIUDRUIANLG APNRIEMMAALTIENSGTRAONUDS CCOYHCALBEITPAATRIROMNETERS GROUP VITI-0: 500 MG/KG/DAY OoDaErsRoorF PERoCFENT PoERrCENT | PoFER McvEciC We eE REcoW rnL aNUMnBER COLDLAETCATION DEASYTSRUISN DAYS IN DIESTAUS DAYS IN PROESTRUS LENGTH (days) INTERVAL (days) : ssaasg6s6e23a 2222 223388, ssasnn 19s% 5s.l0o0 22 66a466662139 22 382%9%. 5577%% 1ssv as5l600 1i : 6s4a66563298a 2210 2254%8 66208% 1158% ssii3e3 11 6saas6651663aa 2ES 5488% 3697%% 93%% 4s3e3 1a 1 s5a46665a712 22 2290%% 5672%u 1l9o%s 5s.i0303 11 sa6a6gss1e2s 222 2293%% s5a7t% amss 54023s3 12 caes70a 21 768 Tan 18 lp 1 6sa4g6s6e022a 2252 13428u 7638% aovs s4.l0o0 52 - sacagseesest 321 2235%% 7677%% osss aa0s 1a1 sa6640a 29 218 798 os 3.0 5 664a665s7342 22 2250%% 7613%% aBwe a5.000 aa "1072 Company Sanitized. Does not contain TSCA C81 9H0--24D7a6y8G:avSaugbeehSrtoundiyc iTnoxRiactistywith One-Generation Reproductive Evaluations DuPon-5990 APPENDIX Z INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION INP, FEMALE RATS os `Company Sanitized. Doss not contain TSCA C81 H902-4D7a6y8;GavSaubgcehSvtoundiyc TinoxRiacistywithOneGeneration Reproductive Evaluations DuPont:5990 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION INP, FEMALE RATS EXPLANATORY NOTES Notes: TestDays52-72 = Premating TestDays7286 = Cohabitation period Abbreviations: D = Diestrus E = Esms P= Proestus X= Nosampleor stage could not be defined from sample. Footnotes: a No evidence of copulation was found; animal was pregnant. --- b No evidence of copulation was found; animal was not pregnant. Two females were cohoused one day late (day 77) with two males that had already mated. - `Company Sanitized. Donotecontsain TSCA CBI ~ 23 FC | : ETI TT BITTTTITTTTT] Er srr ETT a TT EET TTT rr z ETT TTTTT TTT g ET rs TTT g Emme Ter TTT 8 RET etalTarTTTTTTTTTT i [ET ete Tat TTTTTT TTT] [ET ale Tala TTTTTT TT] g [ET lela Tata[TTT Tal1] 9 [El Tletlal TalalTT ET a g EL Tlelal Toi = ele] i jo ofl | la|lfaa lse]] flelalalel gz | [Eells] Joo]fiala lo I=J | PgEoEN(EgeDl OEI GangCE ame a [Else aan Jc 1 = a o |&[Elllale] Ela laoBlIo | > - PE og dE|ENBEEsOEREAE= oGO5E :3803ae3fF OOo9f8 4s9a9o s; [HERE oon ooo aon ao 2 S 2 | Ellelal-Selsiala] ol = | g3y 2 2 | [ENNellnT e = [o|l<aa Se E =eoao|| 52 [se |r aE Toe ateTris 22 | [ellle[alo la Ja |o R=Rs lala Tos | g g [z=] Sie = |---| 2 z [5 [2 ele FEET aE) F] [2lallalaalls a [ies teI = | 8 2 [2[lle lelRaTa Ta 1 0] 52 [z= ol [alle[fo [lo Ra a 1 [=| 23 2 [ze] Ee l=lo ell| 2 i ~ 3E9H lll 3EEEEE CompanySanitized.Dossnot conTtSaCAiCnB ~ [Iso o gmasm gm oa 2 z g g& 4 g 2 g 2 g ETT TTI EO rrrrrrrrrTTT Err EA TT TT ETT ELT rrr rrr ELT rr RETR rr ER eT T TTT ER TTT ere TTT Te] ETT erTal aT TTT s] Ee = TTTa] HEE EEEECE JEOE EEEGO | BL Be-lols ela i of 0 5 [oF Ree eo N- ICEE | 5 2 [Helle ie eo leoMeIo1 ieRT| gE 2 [cl2lelalalalala sic ialscMeTe| - oo B[82on REelcis SSmlalAm jaa3 = a-d $ dE: | [clih Jo Io I | : i a2DB| Efeo 1 eI ReE |e|el e [J ReReee]1 | 2gg 8-|REE[se-lk5% 3gaa8nas3. 8a 38alae| Hgo fcJ a 8fediPe 8R=Am eHd oa 1 da 5 Ele =oI i | 8 EE I | z a a dade EH SEES) $2 [laleeel lela eRa lala1a: [o BSA -[a 8HI 8 H[2Ela5lalAaallsdaalTo=eRaloimomJm oo gz Eg [ER aE 22 " [= = leRe ~ 1c er~ ll | 2 id 254} i 2 ellslafalefalefz fe el iE EEREERERES HY `Company Sanitized. Does not contain TSCA CBI ~5 5 i|[EH GHC 3 ETT TTI ITTT IT EEEE ENEEENEEEENEENNE ETT rrr rr rrrrrr ETT z ECT TT g ECT TT & ELT Tr 8 RTT rrrrrrrrrrr z ETT rrr red ETT TTTrr a g EL Tl TTTTT TTTTTT 1a 9 alla TTTalal TTT (alata) g [EGE AOC 6 i8 :| E[Flmajeelligs]EE lela]|E[R|R[alafala] 0(E5 l[ea2n: FoOEoEnEdo3nsoddos |=]o) 8 EE EEE CE a 2 |[2alelalRln(a=a To Ri |e 3 ~ g- glalalalela] SR Bo Ss 8 o n5 | | B[lEEEiEa]lalE elals Miso o goBs(<aa io] z FR lEsss 5 oan ag 3 oo igFEESSgA|N:FEEcRoR onRaRn ecsawi B35e0al0e| HI] IRL LB a 9 2 CREE RCI Ei g 3 ai & 8 5 5 zz 2 24 o C IT E eTEee| PTT Ra c= [2[eR ES nefafafaa1 a [| [= [= E- - 5I Io [1o ] 5a [R=I fo [= RSfo1 l [fla =| Jolelafa[= 3 lols[3 lalals[se | ~ 3288g] CompanySaniized. Dossnot continTSCA Cal ~ 3 EBITTITI TL TTTITIITTTTT HENENEE EENENEEEEEEEE HENEEEE EENEEENENEENE EET rrr rrrrrr rr z EENENEE EENEEEEENCIEEN E ENNEEEE EEEEEEEENCEEN H ET TTeT al g ETT TTfT ags 8 ELIT TeTTTTT isT e SENENEE EEEEEEECEECR g HENENEE EENEREECEGO00 2 ETT TR TTT TT leelalalal g ELLTI TTTE TT Eelslalalal FgEEF|EE[Een EE[E5EICEERE1 GJ EE S00 POCMEIDICE Cie] CYEAGIOIEE CHE GCE) g g2 |Fie[l2llallealleallsalloll- [llaalalo] MJNelA ele alata| 5 8 [iE Et ER- | . - glee [5] El ST g 2 i $5 | BlhkiEEeERERS] Jalajalalal I 3 EaE8 | [CBRelEeEs]BalaElalk e oieE as lT e| E foEg R |E[cl5e: 3RT= ao a3eo saLoan 32 [Elalelelallalatallae lnaiggnlala] le| 45 32a [[= BMEeeGeE| T S[HAAEE SWNaD nnak)] 3& [=] a Sl] &2 3Z [E== lleEs3 eFIT oeeoa|l & 2 [2]alelalals[8SEaTA aIa [ala [Blafla ala| 4 2: 75& [[[2F]ElEalRalaialohn iefleI=Dla aaIy<fIo[e=olJaE]l[aa| 1EE4 aber E14EHEEEE2[E2[E21E2[E2[E2 EEE5 5EE]3] 9 --~ 35 28 Company Sanitized. Does not contain TSCA CBI H24768:Subchronic Toxicity 90-Day Gavage Study in Rats withOneGeneration Reproduction Evaluations DuPont:5990 APPENDIX AA REPRODUCTIVE TOXICOLOGY INDIVIDUALANIMAL SPERM MOTILITY DATAIN P; MALE RATS Tio -- Company Sanitized. Does not contain TSCA CBI F9-02-4D7a6y8:GavSaugbcehSrtonuidcy TinoxRiactistywith One-Generation Reproduction Evaluations DuPont-5990 INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN P, MALE RATS 0GMRGO/UKPG/1D-A0Y NAnuimmbaelr P_e_Mrocteilnet 664466439708 19050 564466335832 9938 66a466a48430 9%98 6a64s634a016 947 64sa6s3a6z3a 9937 2G5ROMUGP/K1G1/1D-A0Y ANnuimmbaelr PMeortcielnet 664466439516 9972 66446643032 8990 664466335310 989 : 664466439932 9975 664466449055 9925 100GROMUGP/KVG-/0DAY 5G00RoMvGP/KVGI/ID-0AY ANnuimmbaelr p_e_Mrocteinlet ANnuimmbaelr p_e_Mrocteilnet ~ 646466440723 8867 646466439378 8965 646a664a01s0 9957 664466335470 9IH5 663a663a915s 947 646466349041 88a9 664466431672 9952 664466430590 9021 664466345120 8819 646466439887 985 T108-0 `CompanySanitized. Dos notconTtSaCAiCBnI F9-02-4D7a6y8:GaSvuabgcehrSotnuidcyTionxRiactistywithOne.Generation Reproduction Evaluations DuPon-5990 APPENDIX BB INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN P, MALE RATS Tos -- CompanySanitized. DoesnotconTtSaCAiC8n1 H9-02-4D7a6y8:GavSaubgcehSrtoundiyc iTnoxRiactistywith One-Generation Reproduction Evaluations DuPon-5990 INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN P; MALE RATS GROUP I-0: 0 MG/KG/DAY ANnuimmbaelr NToortmaall AbTnaoirlmal AbnHoeramdal TaAiblno&rmHaelad PNeorrcmeanlt 6a4ccaass00 119965 21 a2 00 9987.50 . 66aaccaazoa2 119979 1 3 00 899..55 s64a66437932 119967 20 23 00 9988..50 . 6G4a6g339s52 119976 1 33 00 988..05 6s4a64g0s9 119976 3 ao 00 9988.s0 GROUP III-0: 25 MG/KG/DAY NAnuimmbaelr NToortmaall AbnToarilmal AbnHoeramdal TaAibln&ormHaelad PNeorrcmeanlt _ saac6a3e7s8 220000 00 00 00 110000..00 ccaaeg336s3a 119973 07 30 00 9986..55 aiggaasoss 119986 1 23 0o 9998..00 Gaaccaalls0 119996 00 a1 o0 9989..05 6ia6g33a40 119915 1 85 00 9957..55 - ee Company Sanitized. Doesnot contain TSCA G81 F90--2D4a7y68:GavSaugbechrSotruidcyiTnoRxaictistwyithOne-Generation Reproduction Evaluations DuPont:5990 INDIVIDUAL ANTAL SPERM MORPHOLOGY DATA IN P, MALE RATS GROUP V-0: 100 MG/KG/DAY. ANnuimmbaelr ssaag3asa31 a64s63e30 661466440s0 6Gia6ga31z7s ii663397 NToortmaall AbTnaoirlmal AbnHoeramdal TaAiblno&rmHaelad PNeorrcmeanlt 119978 o1 119986 11 119996 11 210908 00 119978 01 31 00 9989..50 13 Lo0 9998..00 o3 00 9998'.s0 02 00 19090..00 31 0 9989..50 GROUP VII-0: 500 MG/KG/DAY ANnuimmbaelr NToortmaall AbnToairlmal AbnHoeramdal TaAiblno&rmHaelad PNeorrcmeanlt --- 6saas63am0zs 119993 02 1s 9969.55 ssaacea3sslL 119957 20 33 00 997855 GGaacgaaons 119975 01 3a 00 9985.5 c6aa6g3a6s2r 119865 00 1a5 o 9082.'0s sGaigcaaosrs 119998 00 12 0 99990.50 "ios `Company Sanitized. Does not contain TSCA CBI 'H9-02-4D7a6y8G:avSaubgcehSrtoundiyc TinoxRiactistywithOne-Generation Reproduction Evaluations DuPon-5990 APPENDIX CC INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS IN P; MALE RATS Toe Company Sanitized. Does not contain TSCA CBI 9H0-2-4D7a6y8:GavaSguebchSrtoundiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPont5990 INDIVIDUAL ANIMAL SPERM AND SPERVATID COUNTS (Millions) IN P, MALE RATS GROUP 1-0: 0 MG/KG/DAY NAunmibmearl __"ForEpciaduiddaymal SPpeerrmg cauda PTeerstitceusltairs SpermaFtoridsg cestis 6i4c6a4a500 320606..45 17302'0.s1 Gaiggaa0zza 332212..57 111087140.01 iGa6e3ar2s 331792.92 112262381030 iae633s5z 238247..13 1018342.082 664466345079 330654..17 110270850052 14195.21 1212190008 112322..27 112264.59 11293'0s4 8912.65 8s6.s7 a, 8851.s2 88030109 7769.52 GROUP ITI-0: 25 MG/KG/DAY NAnuitmbaelr __"Perspciaduiddaynal SPpeerrm cauda FToerstitceusltairs Spermabtoridsg testis - iic6a3s8s 229828..38 1813067..00 114420..63 9768..15 66ii663336a3 229851..87 8899310038 113124..16 88921.04 6i4c6a4o0a3 227841..77 1100317.21.7 11331100s5 18176..06 a6is6aalls0 22965.82 9112675..14 1212030009 17074..15 G6i46633s4a0 227348..75 893856..57 1122560.13 19048..82 ET `Company Sanitized.Doesnotcontain TSCA CBI 9H0--2D47a6y8G:avSaugbecShrtoundiyciTnoRxaitcistwyithOne-GenerationReproduction Evaluations DuPont-5990 INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS (Millions) IN P, MALE RATS GROUP V-0: 100 MG/KG/DAY ANnuimmbaelr __"FerEpciaduiddaymal SPpeerrmg cauda FTeerstitceustliasr SpermaFteridgs testis 664i66335a31 226657..47 798710..43 113251.60 9733..60 664466335360 228707..61 110022367.21 111392073 899122 0 64a664a0s0s 2326031.30 99471385 114225016 7869.80 6a1i64s17 33009..28 1103672..17 1132003400 1856..12 G4a6g33e97 321688..05 857090..20 112380s6 8781.03 GROUP VII-0: 500 MG/KG/DAY ANnoirmmaelr FOE ididynal Saperm cauda pTeerstiTceusltair Spermeatridgs -- testis --- s16a1g0s6 225787..41 111056980.24 14141..45 2892.80 iag6a3s1l 228598..94 1282335..33 1144960.17 8955..26 6G4a6g4a0i5s 320812..69 11103369..87 1123960.87 8805..85 aGacgas 321464..83 1932280..30 1132840'05 8956..98 Gaaggaasre 228785..89 1808227..36 1213180005 76430.37 1086 CompanySanitized.DossnotconTtSaCAiCBnI 124768: Subebronic Toxicity 90-DayGavageStudyinRatswithOneGeneration ReproductionEvaluations DuPont:5990 APPENDIX DD REPRODUCTIVE TOXICOLOGY INDIVIDUAL MATING DATA AND GESTATION LENGTH: P, GENERATION Cw Company Sanitized. Does notcontain TSCA CBI H9-02.4D7a6y8:GavSaugbcehSrotnuicdiTynoxRiactistywith One-Generation Reproduction Evaluations -_ REPRODUCTIVE TOXICOLOGY DuPont:5990 INDIVIDUAL MATING DATA AND GESTATION LENGTH: P; GENERATION EXPLANATORY NOTES Note Column labeled "Plug Observed" + indicates thatacopulatory plug was observed - indicates that no copulatory plug was observed Column labeled "Litter Produced" + iinnddiiccaatteess tthhaatt anoliltittetrerwawsasprpordoudcuecded Footnote a Because acopulatory plug wasnot observed, the start of gestation is unknown and, therefore, b Sgteasrttatoifongelsetnagttihoncamninsocatlbcueldaetteedr;mgiensetda.tion length unknown. Nolitter delivered, however, implantation sites were observed at necropsy. Tew Company Saniized. Does not contain TSCA CBI H9-02-4D7a6y8:GavSaubgcehSrtoundiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPont-5990 = INDIVIDUAL MATING DATA AND GESTATION LENGTH: P, GENERATION GROUPS: I1-0,1-0 DOSE: O MG/KG/DAY AFNEIMMMAELS c4Gaa6s63ss7sesss csaasgeszszs S6a466s32063 sSaas6seaoss ccaaasggssesosz 66446565s7 SaSiessessse2ss0 GGSiieccseesesensr AMANLDEOL#A1 OBSPELURGVED es6aaacssaaadzsoeo +:: ssaassasn:z :: 6s4a6c3a9r5s +: asascsa) + +ssaaccaa0zss :: ssadceaarrs0 :: sssaaacccaaaseeyrs ::: csaassiusaes :: ccaaesdiozns :: MAANLIEMAL#S2 OBSPELRUVGED PLRIOTDUTCEERD .:: :: :: .: :: :: ::: :: :: LEGNEOSTTAA(TdIaOyNs) 232 23 FFHH 2pF=Hol 2Fl 222 233 108 CompanySanitized. DoesnotcontainTSCA CBI H-24768: Subehronic 90-Day Gavage Study TinoxRiactistywithOne-Generation Reproduction Evaluations DuPont-5990 = INDIVIDUAL MATING DATA AND GESTATION LENGTH: Py GENERATION GROUPS: IV-0,II1-0 DOSE: 25 MG/KG/DAY FANEIMGMAELY sSiugcsessss GSaisesseer Gai6tss703s GGsaiasegssezess Gsassess cGGaiisssssererss2 GSGiieecessssissse GSGiiieecssessr3s0 MAANEDGLWSL eeaassees 66aassd3ensa esadssaeoss sssaaucssaa3riiso0 ssaaseaassrs scaassdasz 666a3sd2sso sseaares 666a3e5a0s saeise OBSPELURGVED :+ :: :: :: :: :+: :: :: +: : MAANLIEMAL#S2 OBSBEURGVED PLRIOTDTUECRED .2: :: :2z ::: 2: :: :3: :: LGEENSGTTHA(TdIaOyNs) 24. 2 2o=o 2F2A 2po nu 22=3 2= 1050 Company Sanitized.Doesnotcontain TSCA Cal 9H0--24D7a6y8G:avSaubgcehSrtoundiyc TinoxRiactistywithOne-Generation Reproduction Evaluations DuPont-5990 ~~ INDIVIDUAL MATING DATA AND GESTATION LENGTH: Py GENERATION GROUPS: VI-0,v-0 DOSE: 100 MG/KG/DAY AFNEDMGMLES Gsiessessesr GGieese2rs GSGiiie6csses0ae0s GGiiigceeessanss GGSiie6cesesos:0s GGiigcsesoss SSiuceeslss GGiic6ess77 Sacers WAMNEDOL#S1 c6aaee3sly c6aaeeaas0e 66aaeeaas0s0 esaaeeanrer sseaaatd 66a6e3aa6r seaeeazsses c6aaseaass 66aasei3a0s 6caaseisrsee OBSPELRUVGED :+ :: ::: :: : :: :: :: +: :: WAANLDOELSS . OBSFEURGVED PLROIDTUECRED :. :: :: ::: ::: :2 :z :: :: GLEENSOTTAHT(IdOayNs) =2 =23 232 25 =2 -= 2x n= T1091 CompanySanitized. DossnotconTtSaCAiC8n1 9H0--24D7a6y8G:avSaugbecShrtoundiyciTnoRxaictistwyithOne-GenerationReproduction Evaluations DuPon-5990 INDIVIDUAL MATING DATA AND GESTATION LENGTH: Py GENERATION GROUPS: VILI-0,VII-0 DOSE: 500 MG/KG/DAY FAENMDAOLLES acaesssir ssaag6eelzs sGiassesa3e GSiessesiess Gsiiseaslz GGiiesss1ezs 8Sie6sso7z0 GGiiegsesszs Gesees GGeiceesa70a Giesiz WANMIEMAL#S1 ssaassaaoms2 ssaassassyn scaassaaotse a6saseaeszs ccaasedaosle c6aaeeaasze 66aaeeaiaslz ccaaeeadsess 646359 s6aaesaasslt caeast OBSPEURGVED +: :: :: :: :: :: +: :: + :. : MAANLDWEASL)S OBSPELRUGVED PLRIOTDTUECRED .: :: :: :: +: ::: :: +: :<: LEGNEGSTTHA(TdIaOyNs) =2 233 52 == 23 222 2" 5165 3oe 2 i092 `CompanySanitized.Doesnot contTaSiCnA CBI H9-02-4D7a6y8:GavSaugbeehSrtoundiyc iTnoxRiactistywithOne-Generation Reproduction Evaluations DuPont:5990 APPENDIX EE REPRODUCTIVE TOXICOLOGY INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY T1093 -- CompanySanitized. Does not conTtSaCAiCnBI H90--2D4a7y6:GavSaubgcehSrtoundiyc iTnorRiacittywith OneGeneration Reproduction Evaluations - REPRODUCTIVE TOXICOLOGY DuPont-5990 INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY EXPLANATORY NOTES Footnotes @ Number of pups bom exceeded the number of implantation sites counted; implantation efficiency cannot be determined. b Litter was counted before delivery was complete; number of pups bor unknown. Implantation efficiency cannot be determined. No litter produced; therefore implantation efficiency cannot be determined. Abbreviations -- = Noda - ae: Company Sanitized. Does not contain TSCA GBI H02-4D7a6y8:GavSaubgcehSrtoundiyc iTnoxRiactistywithOneGeneraion Reproduction Evaluations Dupont5990 - INDIVIDUAL THPLAVTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: 11-0 DOSE: 0 MG/KG/DAY ANnuimmbaerl BPourpsn srNpulnabnetratoifon ImEpelfainctieantciyon Sites 6as653 16 1 646575 5 12 646622 14 1 646466552560 115 138 646503 1 1 6ee46666404 1154 1155 6G4i6s6605515 15= 1156 646557 12 12 664a66559410 113 115 sas64 10 16 646569 1 20 6saa6s66564s 1153 1194 sa.1 75.0 62.4 8500.36 at 15030..30 9-.-8 100.0 9923..93 a 95.0 9728..99 - = Company Sanitzad. Does notcontain TSCA CBI 2904.7D6a8y:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generation Reproduction Evaluations DuPont:5990 ~ INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFPICTENCY GROUPS: Iv-0 DOSE: 25 MO/KG/DAY ANnuinmbaerl BPouprsn. ImNpulnabnetratoifon IEmfpfliacniteantciyon Sites 66445565398 138 1184 19020..50 6ass61 7 7 100.0 645504 1a 15 93.3 664456650239 1182 CasPy 9845..77 645579 15 16 93.8. 645672 13 1 92. 664a6s5s9a6sb 1-6- 1s7 9=4n.1 6as553 1 13 84.6 ee Company Sanilized. Doesnotcontain TSCA CBI HL24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generaton Reproduction Evaluations DuPont5990 - INDIVIDUAL THPLANTATION SITE DATA AND IMPLANTATION EPPICIENCY GROUPS: VI-0 DOSE: 100 MG/KG/DAY ANnuirmbaelr BPourpns ImNpulmabnetratoifon IEmeptliacntiaetnicoyn sites 646547 1 19 89.5 646607 1a 16 87.5 646600 IY 18 94.2 sas6a8 8 10 80.0 646590 12 1 ea "646546 15 15 100.0 646671 1 18 77.8 646521 5 5 88.9 646645 1a 16 87.5 646615 12 15 80.0 646647 16 16 100.0 ~ T097- -- -- Company Sanitized. Does not contain TSCA CBI 9H0--2D47a6y8G:avSaugbcehSrtoundiyc iTnoxRiactistywithOne:Generation Reproduction Evaluations DuPon-5990 -_ INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY GROUPS: VITI-0 DOSE: 500 MG/KG/DAY ANnuimmbaelr BPourpns. ImNpulmabnetratoifon IEmptliacniteantciyon sites 646662 un sa6623 5 6a6619 13 646539 12 646641 13 646572 1 646512 5 646566 10 646602 5 646655 12 646663 3 s64a66567440 -3 6a6532 13 3 84.6 6 100.0 15 1 18050..70 15 86.7 5 [-- 1 64.3 10 100.0 5 100.0 16 75.0 13 100.0 71 2=.9 1 92.9 -- 10% CompanySanitized. DossnotcontTSaCAiCanl H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats withOne-Generation Reproduction Evaluations DuPont.5990 APPENDIX FF REPRODUCTIVE TOXICOLOGY INDIVIDUAL PUP SURVIVAL: F, GENERATION TT099- -- `Company Sanitized. Does not contain TSCA CBI 2904.7D6a6y:GavSaugbcehSvtoundiyciTnonRiactistywithOne-Generation Reproduction Evaluations - REPRODUCTIVE TOXICOLOGY DuPont5990 INDIVIDUAL PUP SURVIVAL: F; GENERATION EXPLANATORY NOTES Footnotes a Nolitter delivered. b Litter was counted before delivery was completed. Nolitter observed; however, implantation sites were present at necropsy. = noe -- `Company Sanitized. Does not contain TSCA CBI H-24768: SubchroricToxicity `90-Day Gavage Study in Rats with OneGeneration Reproduction Evaluations DuPont5990 - INDIVIDUAL PUP SURVIVAL: F) GENERATION GROUP: TI-0 DOSE: 0 MG/KG/DAY MBER OF PUPS ANIL BORN BALOIRVNE PREDCUALYL4ING PODSTNCUL4LING DAY7 DAY 14 DAY 21 MBER SGaassess7s 16s 165 15 .o 55 5s ss Gissices2s2sa 1 Gesss0 is -11 1-a is -- I --88 --s8 --85 8G4e6s5s0a3s 1i6 116 113 55 85 58 88 psraiseeana 11 i1s i13s 55 58 58 s8 cGaagsesssyaa bb -- 1-6 --s ---5 seo5 arss sSaas6ssos7 11s 11 1125 s5 85 85 8| Gssaaas6ssseassd1 151 i31s 151 ss8 888 88 's8 s6ae6s3s6a90a i) --1- --1- ee5 -o --o --s _ sSaassessean 153 3is 55 85 5s 88 ss hor `Company Sanitized.Doesnotcontain TSCA CBI H9-02-4D7a6y8:GaSvuabgcehrSotnuidcy iTnoxRiactistywith One-Generation Reproduction Evaluations DuPoni-5990. =~ INDIVIDUAL PUP SURVIVAL: F, GENERATION GROUP: II-0 DOSE: 0 MG/KG/DAY NOWBER OF WALE PUPS ANINAL BORN BALOIRVNE PREDCAUYLLI4NG PODSATYCU4LLING DAY7 DAY 16 DAY 21 MBER ssaa6sss7ss2 35 35 73 3s 35 33 45 pssraaisseesezarzsta , oo6 s --s s -5 ` --- I 3 --3 a --a a ---3 3 5S4a663s0236 55 55 58 s5 a5 a5 35 ssaas66a0s0 81 81 51 a1 ii a1 31 sages ob ob s a a a Ssaaccesossaa ooo -a --a --a -I] --3 -a Ssaas6ssosnT 10c 10s 1s ia aa s3 ii sSaascssaasi 1s 10s 10s :a 3h 33 ia Ssaasesse2s0a o2o -1 ---12 wea --a --a -I] . Sasacseeseis eo s8 s8 h: 3h 33 Hh Ti CompanySanitized. Doesnot conTtSaCAiC8n1 H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats with Ore-Generaton Reproduction Evaluations DuPont-5990 - INDIVIDUAL PUP SURVIVAL: F, GENERATION GROUP: TI-0 DOSE: 0 MG/KG/DAY NOMBER OF FEMALE PUPS ABNEIRL BRN ABLOIRVNE PREDCAUVLLI4NG PODSATYCULLING DAY? DAY 1s Dara Ssaassss7ss3 ss 6o 67 5a 5a 54 5 Gaassseaasza sa6sso s x8 5 -s s -a 3 -I3 -aPE seI] s8s4au66s5sa02n36 53 3 75 3 53 12 i5 2 33 7 i3 7 33 7 sSuassees0td b i b7 107 H` aa as Ss4acces0ssaa 1 --a- p--ry I--] -a --] --a s5a4c6359517 ss ss 1i h` ii hs ia Gsaac6esdass 55 55 55 3h s: 3h ia s8saa4sc3es6s29e0a on7 5 --7 5 --7 5 I--) 3 --] : --a 3 -a a -- Sassen 7 a 7 3 s 3 a 103Company Sanitized. Donotecontsain TSCA CBI H-24768: Subchronic Toxicity 90-DayGavageStudyinRatswith One-GeneraionReproduction Evaluations DuPoni-5990 INDIVIDUAL PUP SURVIVAL: F, GENERATION GROUP: TI-0 DOSE: 0 MG/KG/DAY mER OF PUPS in SEX RATIO (WALES) % BORN ALIVE 0-4 DAY VIBILITY LACTATTiIoOeNx WER sSaa6sss7ys 00.3530 10000.000 170.050 110000.00 ssaasess2azsa oa- 1007L0 10070 Cl 100.0 5s4a66555206 o07l3e 101000770 0 110000100 11000000 8a46663a0a3 00.'0575 10100070.0 192153 110000.00 p84a6r6e0n4 olascy 1000e0b 1000ob 110000.00 Gis6es6s0s52e 0-27 1007a0 e 10-00 Co 100.0 SGeessssos1? oolms 1100007700 110000.00 110000000 SGaassesiass 0o.s3s8 110000700 11000000 1100001.00 G8easssseasn 0.o6C3 1p007o0 p10o0.y0 ol 10070 -- SSeasseessns 00.6523 110000100 110000..00 10000000 Toa CompanySanitized.DoesnotconTtSaCAiCBnI F9-02-4D7a6y8G:avSaubgcehSrourdiyc TinoxRiactistywith One-Generation Reproduction Evaluations INDIVIDUAL PUP SURVIVAL: Fy GENERATION GROUP: II-0 DOSE: 0 MG/KG/DAY NOMBER OF MALE PUPS. pr BORN ALIVE 0-8 DAY VIABILITY LACITNADETXION sSaasss7ss3 110000.00 10070.05 110000..00 . sascacseezs2a 100e.s0 100--.0 1007f0 y SSaa6css2s6o 11000000 110000.00 1100010010 5sa4s6e0a3s 11000000 1a00o0 11000700.0 Saseos 100.0 100.0 10010 sasasssess21a .ob 2o2b 1002.0 SSaac6es0ssT 110000..00 110000..00 110000.100 ssaa6s3s9a1i 11000000 101000.000 110000100 saseas sass20a 100L0o0 10p0i00 10p0n0y -- SsSaaassss6sesesen 111000000.000 111000000700000 111000000..000 DuPont-5990 . Tos `Company Sanitized. Does not contain TSCA CBI H24768: Subchvoric Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations = INDIVIDUAL PUP SURVIVAL: Fy GENERATION GROUP: TI-0 DOSE: 0 MG/KG/DAY NOMBER OF FEMALE PUPS aNnBoEsR sSaaseess7ys saSssaaesesszss20a S8pa466as520n63 Giceos sases1 sSiasses0s62a 884466559517 ssiacsesiass sa84s6s5a609 -- SSaacseeesss BORN ALIVE 101000..00 100L.o0 1100007700 11000700.0 10L00b 100-70 1010000000 120000..00 100L.o0 210000.000 0-3 DAY VIABILITY INDEX 100070.05 100=.0 101000.100 752s03 10S00b 1007-0 1020000.00 1200000.00 p100o.0 1100070070 110000.00 , Cl0 11000000 110000.00 1S0o0o.o0 100h.s0 110000..00 1000000 0o 10000 10000.00 DuPont-5990 "T06Company Sanitized.Dossnotcontain TSCA CBI H9-02-4D7a6y8G:aSvuabgcehrSotnuidcy iTnoxRiactistywith One-Generation Reproduction Evaluations DuPont-5990 ~ INDIVIDUAL PUP SURVIVAL: Fy GENERATION GROUP: TV-0 DOSE: 25 MG/KG/DAY NoMBER OF PUPS ANIL BOR BALOIRVNE PREDCAUYLLI4NG PODSATYCUL4LING DAY? DAY 14 DAY 21 8s4a66365398 31 113 11 s8 o 55 s5 GGuicessoena oo7 --2 .2 --2 ---7 se3 aes7 psriissnza i -w - .5 --8 ee8 --s Gsiuceennaa oooo .-- ---- ------ ---- --- -= 884466562093 2is 1i 11 55 s5 I]5 .a ssiuesss7s5aa oios -5- -i a7s se Jy _8l Saascsee7s2s o3o -n -n- -- --5 --5 =.s Gissean - -- -- --- - ane ee 8c4i6e5s9e6s 1b 6 b10 15 5 s5 s5 s8 Guessaa --- -- we fi 2 Ll --_ 8a4c65o53n o1o e1e o1e --o --5 =5 -s Tor CompanySanitized. Dossnot containTSCA CBI H9-02.4D7a6y8G:avSaugbcehSrtonuidcy iTnoxRiactistywith One-Generation Reproduction Evaluations DuPont:5990 - INDIVIDUAL PUP SURVIVAL: F, GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY NOMBER OF MALE PUPS ADL BRN BALOIRVNE PREDCAUYLLI4NG PODSATYCULLING DAY? DA 14 Dar 21 NoMBER Ssaasss6a8 10 10s 10` 3 3 ` 3a GSeecssssesra 5 i.s --s --5 --5 sesses pseens7ia oory -u-n --1 --5 -5 --5 -5 Gassera oo fo. --- - - - - s8si4es6ce5e02i39a ouon5 --n5 _15 Es:5 -a5 ---i5 --i5 8Gaucsss7s9aa oo5 ---5 f.5 -a --a -a --i SGeessesre2an oo5 es5 i.5 -- --` --i --p Gsuusessasaa b oo b - --3 --3 -3 ee3 ---3 Ga6596 seessea oo5 --5 --5 --3 sera -a Js --- SGeuscsraon oo2 --2 -2 .2 -2 -2 =2 Tios Company Sanitized. DoesnotcontTSaCAiCanl 9H0.-2D4a76y8G:avSaugbceShrtoundiyciTnoRxaictistwyithOne-GenerationReproduction Evaluations DuPont-5990 - INDIVIDUAL PUP SURVIVAL: F; GENERATION GROUP: Iv-0 DOSE: 25 MG/KG/DAY NUMBER OF FEMALE PUPS ANINAL BORN ABLOIRVNE PREDCUALTLAING PODSATVCULLING DAY7 DAY 14 DAY 21 MBER Gsuaessss8 7s 75 5s aa 3a ia `4 cSaassssesrsa ooo1 --1 -1 es1 --1 -1 --1 ssaa6gss0maa ooo3 --3 --3 ---3 i.3 --5 ass3 sassera oo -- -- --- sez wen a ssaa6s5e2n0na ooo3 --3 --3 ---3 --3 --3 33 s64a6s6s0s3ea okel --kl --7 --a --i seyi aes3 sa6s79 cassia oo` --s -5 --a --a J3 _a Saserz 8 5 5 a a i 3 asseea ooo -- --- ee es -- = spargiseads b 7 b5 5s si a5 3s :5 - saasssesreoan oo-o --- ---- E-e ---- --- w-s pride 5 5 5 ` s s -ue Company Sanitized. Does not contain TSCA CBI 9H0--2D4a7y6G8:avSaugbeeShrtoundiyciTnoRxaictistwyithOneGenerationReproductionEvaluations DuPont-5990 - INDIVIDUAL PUP SURVIVAL: Fy GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY NOMBER OF PUPS EamRo SEX RATIO (ALES) % BORN ALIVE 0-4 DAY VIABILITY LACTATTiIeOxN psa6esss 00..5466 110000.00 10840'.s0 110000.00 . Ssaassssesrsa [xLC 1p0o0.0 1007o0 l 2 1000 s6aa6ess0Taaa f0o.7% 10L0o0 1007j0 y 100L.L0 ' ren je --- jo -- ssaa6s5e2a01a h0.o75 100--.0 100--70 100-.0 pre ole 100.0 1000 10000 pprrees) 0.60 10p0d0 1007p0 y 0L.0 ssaasssee2aa 0.38 10o0s0 100C.o0 ol 100.0 pGresesa) --zsh -"ob wpny 100--.-0 pried 0.56 os 100.0 1000 _ sGaassss7s0ean .-- o-o. --- _--- 646353 ote 100.0 100.0 100.0 Tio `Company Sanitized. Doesnot conTtSaCAiC8n1 H-24768: Subchronic Toxicity 90.Day Gavage Study in Rats with One-Generation Reproduction Evaluations - INDIVIDUAL PUP SURVIVAL: F, GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY aMBmER sSeess6s3s8s GeBsessssearn aGeesssso7na aesswra Gseesssea3sia Gece0 ssiaesss7s9aa 6eSsess6e7a2n Gessean pser6543 Gasssan --_ s8aesssss730n BORN ALIVE 110000..00 100L.o0 1007L0 --100o7o0 100j.n0 1007L0 100j.y0 100a.0 jo 1007--0 MBER OF WALE PUBS 0-4 DAY VIABILITY acTmWaDEnXon 110000..00 100o.s0 10L0o0 po 1007-0 100L.0 100a0s0 100.00 100".C0p po 10h0o.0 110000.00 100p.y0 L10l0.0 ol 10--00 100o.s0 100po.n0y 10j0o0 110000..00 jy 100-.0 DuPont-5990 Te Company Saniized.DoesnotconTtSaCAiC8n HL24768: Subehronic Toxicity 0-Day Gavage Study in Rats with OneGeneration Reproduction Evaluations - INDIVIDUAL PUP SURVIVAL: Fy GENERATION GROUP: TV-0 DOSE: 25 MG/KG/DAY NUMBER OF PEUALE PUPS nos BORN ALIVE 0-a DAY VIABILITY LACITNADETXION G4a65s3s0 10100.000 10l0.e0 120000..00 sSaasssseora 100.-0 1003000 100z.l0 saGsa6ss703sa 100j.0 100e.s0 1002.0 scaassseerraa -- po-! eis. 8s3a668s0235 110000700 1100000000 110000000 sSaaesss7ssa.a 100L.0 100n.s0 wjry Gisagsesre:ia 100j.y0 100p5o0 100C.L0 Gessaaa --- ne ol Gsaes6ssao3s naa 100a 70 110000.000 sasssee - sigsr08 ---- G3 _ jis a Suess 100.0 10070 100.0 DuPon5990 Tia `Company Sanitized. Doesnot contain TSCA CBI H9-02-4D7a6y8G:aSvuabgcehrSotnuidcy TionxRiactistywithOne-Generation Reproduction Evaluations DuPont-5990 ~ INDIVIDUAL PUP SURVIVAL: Fy GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY NOMBER OF PUPS NAoNuIBOENR. Bo ABOLRNE PREDCAUYLLI4NG PODSTACYU4LLING DAY? DAY 14 DAY 21 Gasser n n 16 s 3 2 Gsiesses0e7d o1o -a -1- -5 ---5 -- --o s8i4s6s020aa 7 -o Joo --s --s --F-H os5 SSaasseoaas 2 125 125 88 85 c5 HsH GBaassessaisa ioso -i -5 sez5 ses8 as8 ws5 SSaageesr21 1o fe}5 fe}5 5s 8 s8 s5 Ssaucsesaoso.a 1 -2- e2e ee5 ee8 --7 .7 saesssa oon --- --- -------- ssuasssssoosaa --- ---- --- --- ---- ----- sSaucses1zs7.a 2 -2- -2 ee5 --5 --s -5 . pre) susersa oo1o ---i -5 --5 --5 -5 -5 Is `Company Sanitized. Doesnot containTSCA CBI 9H0--24D7a6y8G:avSaubgcehSrtoundiyc iTnoxRiactistywithOne-Generation Reproduction Evaluations DuPont5990 - INDIVIDUAL PUP SURVIVAL: F, GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY NuMBER OF MALE PUPS Mme. BRN ABLOIRVNE PREDCAULYLIANG PODSTACYUSLLING DAY? DAY 18 Dar 21 6esser ` 2 2 Gissec6s0e7sa 8 --5 --5 --3 -3 -- . 8G4u6s5s0a0en oo5 ---5 --5 --a --3 --3 --a GSeeecsesaas 5` 5e 55 35 35 35 a5 Gecsas 5 5 5 3 3 3 i Suacceerna 3 --5 --3 --3 ---3 --2 es2 Gesa 2 2 2 2 2 2 3 Ssiuceesaosoa oo7 -- --5 --3 --3 --3 --3 sassssa ---- -- -- -- --- --- -- Gsuuccseaossna oo -i. ---- ---- ---- ---- ----- Sace1s a I] i a a a i _ Ssaassesazrra fe --Bs --5 --5 -5 --` -` aserse oo --- -- -- - . - He Company Sanitized. Does not contain TSCA C81 F9-02-4D7a6y8:GavSaubgeehSrtoundiyc TinoxRiactistywithOneGeneration Reproduction Evaluations DuPont-5990 = INDIVIDUAL PUP SURVIVAL: F: GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY NUMBER OF FEMALE PUPS ANIMAL BORN BALOIRVNE PREDCAUYLLI4NG BODSATYCUL4LING DAY? DAY 14 DAY 21 mer sassar 5 sacessa --5 w2e aes. seps oo1 2o uSasss6a0e7a oos -5 -5 --I] --2 or -- GS8aa4cc6ss6oa0ds0 h25 a28 a25 a2a a23 225 223 : sSaassedrsa oo5 -5 --5 esh esa -s3 .y3 Ssuaessen 1s 0s Bos 55 `5 5a 53 Gsaaccesaos0a ooo7 -s _5 as3 avsI) --: _a saassossssaa oon -- --ave a-te -ces =Ll 2 = aSassseerssn oo5 --5 -5 -b ws -a -a . Ssaacsesaarra oo3 ---3 ---2 --2 --2 f2 2 sacersa oo --- -- -- -- sen an Is `CompanySanitized. Doesnot contTSaCAiCnBI 9H0--2D4a76y8G:avSaugbeehSrtoundiyciTnoRxaictistwyithOne-GenerationReproduction Evaluations DuPont:5990 - INDIVIDUAL PUP SURVIVAL: F, GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY NOMBER OF $US aWvER SEX RATIO (MALES) % BORN ALIVE 0-6 DAY VIABILITY LacTaTTuIpeOxn ssaassse4s7sa 0.20 100J.L0 51L.1L 25j.n0, Sace0r 0.57 100.0 100.0 oo saSsacseaoaoa 0.-53 100o.o0 iJ 000 a-5- S8S4aa6cs5ea9d4s o0o.ll7se5 111000000.000 10110000101000 11700500...000 saBssaasessee2n11a 00[221s 10002L..o05 11000f0.00 106012i0.5 Ssaassesaos0a 0i5.0 #-7 10jo0.0 opso ssaesssss0ssaa ---- ---- --- -jo sseissseassa 0-3 10_00 10-00 100-70 -- sSaisssedzr78 oClL en 100L.o0 9LL8 100L.0 sess7sa Lo j jay - TTiteCompany Sanitized. Does notcontainTSCA CBI H902-4D7a6y8G:avSaugbcehSrtoundiyc TinoxRiactistywithOneGeneration Reproduction Evaluations - INDIVIDUAL BUP SURVIVAL: F, GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY NUMBER OF MALE PUPS ano BOMN ALIVE 0-4 DAY VIABILITY LACITNADETXION 6c4e6s5e4s7sa 100z.l0 100.?0 500.0 Gise07 sass24a Lo 100.0 100J.L0 oae GGiisseeaonn 101000710 0 1010001700 11000700.0 Ssii6s5s9i4s 11000000 101007000 1100007100 SGaessee7s11a 100-.0 p100o70 6p.y7 GGaassss2s1oa 10-00 10o0n0e 10p0oi0s SGiassesisssa 8.07 100-.0 75200 6466052 --- - = Ssaisssesssa 100--70 100_70 10o0.0 . sapsse272 10jo0.0 100o.y0 100z.l0 6ase750 - ee py DuPon5990 EE `Company Sanitized. Does not contain TSCA CBI 'H9-02-4D7a6y8G:avSaubgcehrSotnuidcy TinoRxaitcistywith One Generation Reproduction Evaluations ~ INDIVIDUAL PUP SURVIVAL: F, GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY NUMBER OF PENALE PUPS. na BORN ALIVE 0-3 DAY VIABILITY LacITNaDETXION siss46e5s4s7a 100.e0s 02p.d3 02.20 Gise0r sass2sa 100L.L0 100e.r0 oo GiGciceeeono 101000..00 110000.00 1703005.0 Srissnas 101000.000 11000000 15000.00 SGaegseers1a 50L.5 100x.0 50jo.e0y Giss21 6asso0a 100-00 10a0n0s 100p.n0y GSiassesisssa 5.L7L 100e.e0 10200 G4s605e --- = = Gsiasserssaa 10a0t0s 100--.0 100_.0 Ssiecsess2rra 10_00 jsyr 100p.s0y - Gese750 jo ae 2 DuPont 5990 . "Tis: `Company Sanitized.Dosnot conTtSaCAiC8n1 H19-02-4D7a6y8G:avSaubgcehSrtourdiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPont.5990 ~ INDIVIDUAL PUP SURVIVAL: Fy GENERATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY MBER OF PUPS ANIL BOW ABLOIRVNE PRECDUALYLING FODSTACYU4LLING DAY? DAY 14 DAY 21 ower sass6z un un 1 5 5 o csaaseeszesra i -- Be5 --5 -1 -- -- 8s4a6s3e310a 11 132 s 0 s 3 ssaasseelzceea oo ----- ---- ---- ---- .--- -- sSaassesaerra fe pei --1- --s --7 = =o sassasas6sss1e7zs2 1105 135H 5so 585 s75 3 500 aSaesseoozn oe5 .5 ---5 --5 es5 -- --o sGaassesseaa -1o- -0 e1s0 -5 a --- ay GS4ess6e6d3oc 1 --10 --s ---8 y5 aes5 wzs _ Srisnsi 33 1o 12o 5 8 ` 2 Th: `CompanySanitized. Does not containTSCACBI 9H0-2-4D7a6y8:GavSuabgeehrSotnuidcy TinoxRiactistywithOne-Generation Reproduction Evaluations DuPont5990 INDIVIDUAL PUP SURVIVAL: F, GENERATION GROUP: VITI-0 DOSE: S00 MG/KG/DAY MBER OF MALE PUPS mmoew Bmw ABLOIRVNE PREDCAUYLL4ING POSDTAYCULLING DAY? DAY 14 DAY 21 sasee2 uessan oo. -. -- --s =4 --o --o psirse23 53 53 02 2 oo + 84639 a a 4 s 1 . Gac2ea oo acerca see . -- - we -- -- l = J . GSuaecsesaarn oo5 --a =a --a --3 =o s8i4s6s51722 57 s5 5a 53 52 Sases Gass7on ooos aes 5 --s --s s =2 oo1 sase02 sacsaa 3 3 -- --5 on3 as3 -- J SSaasgseesrs 57 5 H 33 32 3o 3 prsiacecsit0a -o Ie]e ses seno o --- Saez s 8 8 3 3 1 1 Ti: `CompanySanitized. Does not contain TSCACBI 9H0--2D47a6y8G:avSaugbeeShrtoundiyciTnoRxaictistwyithOne-GenerationReproduction Evaluations DuPont5990 - INDIVIDUAL PUP SURVIVAL: F: GENERATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY MBER OF FEMALE PUPS amAL BRN ABLOIRVNE PREDCAUYLLAING PODSTACYUSLLING DAY? DAY 14 DAY 21 ER sases2 sassmaa oo2 -' ekel --s --2 j -o 8SSaa4ss6ee51z3s39 553 555 hi05 s3 3 1 00 Geceann oo sasi6a on -i --- see es som . J = -- --- sSaucseseerza s ---7 --7 py3 ho 3 -o = o sSaasss7122 37 37 31 33 23 0 o sSaaecss7eosn oo3 esa aesh iy3 .s oo2 2 Sace02 sucsaa 2 --2 ---2 --2 --2 -- --- Ssaacseeesss s5 5a 35 33 32 2 2 psrasesa0a ooo3 - .o -- -- es aseo -_ sass32 5 5 h 3 3 3 1 TT `Company Sanitized. Donotecontsain TSCA C81 HL24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont5990 - INDIVIDUAL PUP SURVIVAL: F: GENERATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY NOUBER OF PUPS avn SEX RATIO (MALES) BORN ALIVE 0-6 DAY VIABILITY aeraTtiEoxn NoMBER sesee2 0.3 100.0 100.0 0.0 sassasseezr3a o'esr Sase1s 0.38 110000...00 8op0ld30 -o2o Gaesas fH 100.0 6.7 oo sass200 fa -- . i ssaesses1esaae .- -- ---- --- sSaisssa7l2 0075308 a52es 1060710's 0I0 sSaas6sse1s2 0o.'6e0r 10500..00 110000700 3oso Gecseeeso7z00 o'Lso0 100L0o0 100L70 oatos Sseessessssze o'[s 5-03 10jo0.0 oJoy sSei6sseason olLsl0 7j.5 50=.0 ajs - GiGeeess7aaz ol0.e00 1000000 02--.3 25e0d0 - a= `Company Sanitized. Does not contain TSCA C81 H9-02-4D7a6y8:GavSaubgcehSrourdiyc iTnoxRiactistywith One-Generation Reproduction Evaluations pWr ER ssaas6e6r2a S8a46666z135 s84a6s5e329ea ssaascsee1r6a S8Sa4ac6ce8sa71r2s Sacses saS6acse70028 sSaacsessesa.n Sasees pseessnion --- Sas32 INDIVIDUAL PUP SURVIVAL: F; GENERATION GROUP: VITI-0 DOSE: 500 MG/KG/DAY BORN ALIVE NOMBER OF MALE PUPS. 0-8 DAY VIABILITY LAICNTDAETXION 100po.s0s 1002.0 0.0 11000..00 60..70 ohoi 10o0l0 10020 oo --. .- -= 1880050070 1100s600...700 000..000 jaols 100pe0i0 23j.y0 100p.n0y 100.0 ooeo 5al7s 10000.00 750000 -oI- -oI op--o 10000 10070 2.0 DuPont-5990 . TT `Company Sanitized. Does not contain TSCA C81 H9-02-4D7a6y8:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generation Reproduction Evaluations -~ INDIVIDUAL PUP SURVIVAL: Fy GENERATION GROUP: VIII-0 DOSE: 500 MG/KG/DAY aNomuER Gases ssiesseszasza s8ies6es13s9 sseessee126s0e Gseessesaetsa GeSsesss712z sSeesssse7s00 Geseoz Ssiessessasze Ssaassssedron - pprrient BORN ALIVE 100.0 10j07o0 11000100 0 jo-- 57i..5 101001000 10f0y0 1000 8j.y0 a-s. 1000.00 NOMBER OF FEMALE PUPS 0-8 DAY VIABILITY LACDTNADTEIXON 100.0 0.0 100-..0 --oo 5000.00 oJoo --- --=- 1007--0 0--.0 100577.01 00..00 10j0o 0 50--.0 10070 oo 100.70 0j%y 100--0 so-lo 0Z.Z0 25o0 C DuPont-5990 Tas CompanySanitized. DoesnotcontainTSCA CBI H24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont.5990 APPENDIX GG REPRODUCTIVE TOXICOLOGY INDIVIDUAL PUP WEIGHTS: F, GENERATION Ts Company Sanitized. Doesnot contain TSCA C81 H9-02-4D7a6y8;GavSaubgcehSvtoundiyc iTnoxRiactistywith One.Generation Reproduction Evaluations -- REPRODUCTIVE TOXICOLOGY DuPont5990 INDIVIDUAL PUP WEIGHTS: Fy GENERATION EXPLANATORY NOTES Footnotes a Nolitter delivered. b Litter was weighed before delivery was complete. One pup was missexed; data were excluded from male and female mean pup weights. a Nolitter observed; however, implantation sites were observed gt necropsy. e Nolive pups. Jf Nolive male pups. & Nolive female pups, - ie -- Company Sanitized. Does not contain TSCA Cal F-24768: Subchronic Toxicity 90-Day Gavage Study in Rats withOneGeneration Reproduction Evaluations DuPon-5990 --_ Individual Pup Weights (grams): Fy Generation Lactation Day 0 Group: 11-0 Dose: 0 mg/kg/day J------ up Number Bomber Sex 1 2 3 4 5 6 78 5 10 11 12 13 646653 g 7.80 7.30 7.60 6.20 7.60 7.60 7.60 7.60 646575 $ 77..9300 78..8100 76..9900 7.10 7.50 7.20 6.00 6.50 9 7.207.507.30 7.70 7.30 6.70 sassesa 646622 $6.70 6.7066..5300 66..570066..7500 66..2200 66..6600 6.40 5.70 646550 9 66..6600 66..8400 76..1000 56..9700 56..9600 66..2000 6.60 6.30 6.60 646526 8.20 8.10 8.40 7.80 88..2100 7.80 8.20 8.00 7.30 9.20 646503 2 78.19100770.5300 77..9500 86..3500 87..2200 77..6200 88..1200 7.00 7.70 646644 2g 76.163007.00 7.30 6.80 6.60 6.70 6.60 4.50 6.90 6.60 6.50 7.00 6.30 646604 2 6.50 6.20 6.70 6.70 6.60 6.40 6.40 6.30 6.50 4.20 66..1600 65..3800 6.90 - 6a6651b 2& 78..510077..2500 77..9700 77..7200 76..2200 68..6000 saess2a & 646606 2 66.14600 66..4100 66..9400 66..7300 6.10 6.40 6.40 6.40 6.20 6.20 6.10 646557 9 8.20 7.70 8.00 7.70 7.60 7.60 8.50 6.90 77..8400 87..4600 646591 7.10 6.70 7.40 7.10 7.50 6.90 7.20 7.00 7.30 7.10 646544 76..6500 76..3700 76..4900 86..1900 8.70 646646 9 66..5900 67..5900 57..8700 58..9100 75..1900 67..2400 57..9400 57..5700 5.80 5.80 9 5150 5.70 5.70 5.70 5.30 5.70 5.00 5.00 stesa0a 646569 55.540055..2500 65..1300 55..7700 65..0500 55..6300 45..7300 5.50 4.10 6.20 5.90 5.60 646654 76..5600 66..4700 76..2500 66..9200 66..7700 6.50 7.30 7.30 646668 g 77.180077..6400 77..7400 76..5700 77..2100 77..5200 77..7100 7.40 Tis Company Sanitized. Doss not contain TSCA C81 9102.4D7a6y8:GavSaubgcehSrtoundiycTionxRiactistywith One-Genersion Reproduction Evalustions Dupont59%0 _ Individual Pup WLeaicgthattsio(ngrDamasy):0 Fy Generation Group: 1v-0 Dose: 25 mo/kg/day -- Rimbor--S 1 2 3 4 5 Pup Number 678 5 10 1 12 13 646638 7.10 6.90 6.70 6.70 6.80 6.80 6.40 6.30 6.30 6.60 646559 $5 68.11400661.2900 76..3100 67..7900 57..2800 67..1900 6.30 6.30 $ 61807.10 7.20 7110 7.30 7.30 7.00 6465982 & 646561 $ 8.600 8.80 8.10 8.30 8.30 8.40 . 646573 & 646504 &$? 66.260056..5000 56..9600 66..5400 6.40 6.30 6.50 5.80 6.30 6.40 sassera & sagen &? 646529 56..7500 66..8000 66..4200 6.80 6.20 6.30 6.20 6.60 6.60 _ 646603 65..700056..9400 66..210056..9900 55..7700 56..9400 65..2700 6.00 6.10 5.90 6.00 sagssaa & 646579 56..240056..8600 65..0800 65..5700 65..3600 66..4700 6.30 6.50 6.20 sasseea & 646672 5$ 87..4700 88..4400 86..5200 88.3900 78..1900 8.40 8.60 7.80 646584@ & Gusasb $ 77..7200 76..0800 7.307.00 7.70 646596 652.0650.905.90 56..5600 55..5000 6.44.060 6.30 6.00 6.40 6.80 6465582 & saser0a & 646553 761310076..3200 6.00 6.40 6.20 6.40 6.60 6.30 6.30 - = CompanySaniized.Does not contTSaCAiGBnI 2904-7D6a8y:GavSaugbechSrtouidcyTionxiRcaitstywithOneGeneration Reproduction Evaluations DuPon5990 --- Individual Pup Weights (grams): Fy Generation Lactation Day 0 Group: vI-0 Dose: 100 mg/kg/day M--imb--or Sox 12 3 4 5 P5 up7 tunber8 9 10 1 12 1 646547 66.14200 66..9600 65..3900 66..6200 6.40 6.70 6.20 6.10 6.40 6.70 6.20 6.40 6.20 sasessa % 646607 g 77..1600 76..2500 76..4900 76..7400 76..0600 76..3400 6.50 7.30 suss20a 546600 5 66.16000561.7400 66..0500 66..1100 65..7500 66..2200 66..3200 66..5800 6.20 546648 5 $ 76l150076..0700 6.00 7.10 6.90 7.20 546594 5 $ 6606.70 6110 6.60 56..9000 65..8900 6.00 6.60 6.30 7.10 646546 3 $ 6.10 6.50 6.05.40 6.00 5.60 66..4200 66..3100 66..2500 6.10 5.70 6.20 s64a6s6e7s11a &5 6.50 7.20 6.90 --_-- 6a6s21 @ 67..8900 86..3600 6.10 6.00 6.506.106.707.00 6.90 6.30 sasso0a $& 7907.30 7.50 7.60 7.50 5.60 646645 25 6.70 6.50 6.40 7.10 6.40 6.30 $ 6,405.80 6.80 6.20 6.40 4.40 6465558 & sas6osa & sassesa & 646615 $ 78.620077..1700 77..2200 77..9200 7.20 6.80 7.40 7.90 6as27a & 546647 3 $ 7.30 6.50 66..8500 76..0800 7.30 7.00 6.80 6.90 7.50 6.30 7.00 7.10 6.40 7.20 saser5 & - we CompanySaniized. Doesnot contain TSCA CBI H902.4D7a6y8:GavSaubgcehSrtoundiyc iTnoxRiacittywith One-Generation Reproduction Evalutions DuPont 5990 -- Individual Pup WLeaicgthattsio(ngrDaamys)0: Fy Generation Group: vITI-0 Dose: 500 mg/kg/day Maniibmearl SPeukp 1 2 3 4 5 P6opSu7tesr 9 10 1m 12 wm 646662 4 2 6.60 6.40 6.105.80 6.70 5.50 5.80 6.00 5.80 6.20 5.30 LE] 46623 9 7.20 6.90 5706.60 66..9900 546619 2 66.1280077..0000 66..510076..050076..2300 5.70 6.00 5.80 646539 65.16400 66..3200 66..5000 66..6500 6.10 5.30 5.30 5.90 sass2ea & sase16a S sussea 646641 2 6.90 6.00 6.80 6.30 6.70 6.60 6.00 5.80 6.40 6.20 6.30 - 646572 55.380046..9100 55.16500 461.9000 55..4000 55..38005.70 646512 66.230055..0700 66..4400 6.50 6.00 6.70 646566 2 6.60 6.50 6506.20 76.11500 66..4500 6.70 cassr0a 8 suseoze 2 7.50 7.80 6805.30 6.20 Gussza & 646655 & 56..4800661.3200 66..8200 55..9800 6.00 6.50 646663 g% 55..740055.6200551.5900 55..3700 55..4300 sacsa0d & sassrae 646532 2 7.80 6.50 6.50 6106.30 6.40 76.10500 66..7200 6.60 7.20 6.70 ToC CompanySanitized.DoesnotcontTSaCAiCBnI 9H0L2-4D7a6y8:GaSvuabgcehrSotnuidcy TinoxRiactistywithOneGeneration Reproduction Evaluations DuPont5990 . IndividualLaPcutpaWteiiognhtDsay (4graPmrs)e:culliFyngGeneration Grow: 11-0 Dose: 0 mg/kg/day Mainnibmealr Speuxp 1 2 3 4 5 6 Top7 Super8 9 10 1 12 13 646653 1110.08811011.84 1110..80 1122..70 1111..38 1101..59 1103..63 66575 1143.0591123.1171134..2013.2 14.2 13.3 sassasa 646622 1100..051100..771100..96 1110..35 1101..62 1100..02 10.2 11.1 - 646550 & 77..920077..6500 77..3600 77..0400 67..6600 66..7900 6.80 7.40 7.30 646526 1150.0591165.1511450.73 15.0 15.1 15.4 14.6 13.6 646503 9 1114.071132.731141.531133.0101142.182 14.1 13.4 14.3 sagsaa 95 1121.:6512.411.811.4 11.6 10.9 10.8 7.90 10.4 11.1 13.1 10.9 646604 9 91.06.0791.18.0099..4000 1100..24 190..540 1110..32 161..520 10.6 - 646651 111.13100.19111.1311031..62711101.1.49011115.77 11.7 10.6 12.2 12.1 sagss2a 8 646606 2 1110.0871113.1721111.111111..30 10.8 10.6 10.5 11.1 10.2 10.7 10.3 646557 12.413.012.8 1203117126 13.0 11.7 13.0 11.6 11211.35 646591 2 120412111312 10091214110 1111..86 115 11.8 11.0 12.6 12.7 11.2 645544 14.6 13.8 13.6 15.5 14.9 646646 19.38.0518.38.00192..604183..680 1131..60 170..180 192..990 1104..93 10.0 11.1 stsana 8160 10.4 10.19.00 8.60 9.90 8.90 10.7 646569 &9 95..3200991.2000 180..250 88..3500 97..7800 79..3000 78..7100 6.90 8.80 10.9 9.00 9.10 646654 9 113l.s811231.102110.081122..011131.026 12.7 12.6 13.5 646668 9 1111..681122..6211210.801102..39 1110.54 1131..04 1121..42 13.4 EEE - Company Santized.Doesnotcontain TSCA CBI 9H0-2-4D7a6y8:GavSaugbcehSrtoundiyc iTnoxRiactistywith One-Generation Reproduction Evaluations DuPont-5990 --_ Individual Pup Weights (grams): Fy Generation Lactation Day 4 Preculling Group: 1-0 Dose: 25 mg/kg/day Animal Pup PupNumber Number Sex 1 2 3 4 5 67 8 9 10 nm 12 13 646638 9 11011.2111001.86190..870 91.12.04 151..630 190..640 192..800 191..670 11.4 10.8 646559 9 11232.411330.8011120.241112.0201122..3213.7 6465982 8 . 646561 16.217.116.116.4 16.5 16.5 9 15:2 6as73a 8 646504 11.3 11.010.9 10.5005 1007 10.7 10.8 10.0 11.2 11.1 10.8 11.5 10.9 sassara &2 s64a6g562301a &2 12.113.512.612.912.413.7 13.2 12.9 12.3 646603 ? 1102.20.4110.16.71112.38 10.1 10.6 9.50 10.7 10.6 11.5 10.5 10.4 ~~ 9 9.90 9.60 9.50 11.110.47.90 10.3 Gagssea &2 646579 9.90 9.60 10.2 10.6 10.2 8.20 10.5 10.6 10.0 9.40 9.40 9.60 10.2 9.40 10.5 6a6s6aa 8 646672 9 11540.1111540.5911350.251152.055 1154..41 14.0 15.4 15.5 664a6s5s4e3aa & 16.015.114.0 646596 9 1105..001141..23194..500 1113..38 1122..10 9.50 11.3 11.7 11.6 11.05.60 10.8 10.8 10.3 Gagssea & Gage70a & 646553 13.213.3 ? 11.812.210.911.812.2 11.9 11.2 11.7 12.4 TT `Company Sanitized. Does not contain TSCA CBI 9H0--24D7a6y8G:avSaugbeehSrtoundiyc iTnoxRiactistywith OneGeneration Reproduction Evaluations DuPont-5990 ~ IndividualLaPcutpaWteiiognhtDsay (4graPmrse)c:ulliFingGeneration Group: VI-0 Dose: 100 mg/kg/day _Mi_be--r Sex 1 2 3 4 Pup Nusber 5678 9 10 11 12 13 646547 81.02.07971.4100 8.60 10.0 800 9.50 11.0 9.50 9.60 8.00 9.50 10.5 11.0 10.4 sasessa & . 646607 81.02.09170..320 88..9600 78..1600 190..10079..9000 8.60 8.70 , sags2aa & 646600 2 10.3 10.19.90 10.9 11.6 9.301008 11.6 10.08.10 7.60 11.4 11.3 10.6 1121..44 11.7 648648 1142.4011340.09 12051311 13.0 13.4 648594 11.013.012.912.8 12.3 12.7 11.6 10.4 646546 2 1100.0881110..25 1111..25 191..600 10.6 8.90 10.3 9.00 11.0 210.310.3102 11.4 11.1 8.70 6assra & - 646671 88..440099..2500 190..020 9.60 8.00 8.70 8.80 8.80 8.80 10.0 6ass21 1122.1411121.3912.77.80 11.2 12.2 6465908 & 646645 9 1121.2611120.421123..1311130.90170..530 1121..46 sagss5a &2 sas6052 & cassesa & Gass ? 1122.091122..491123..411121048 13.0 11.9 12.5 12.0 6ass27a & 646647 2 10.9 8.60 9.308.30 9.90 10.0 9.00 10.3 9.00 10.8 10.6 10.0 10.7 9.90 9.10 6as675a &? EE -- `Company Sanitized. Donotscontsain TSCA CBI 9102.4D7a6y8G:avSaugbechSrtoundiyc iTnoxRiactistywithOne-Generation Reproduction Evaluations Dupont5990 --- IndividualLaPcutpaWteioinghtDsay (4graPmrse)c:ulliFyngGeneration Group: VIII-0 Dose: 500 mg/kg/day MAinmibrealr SPuepx 1 2 3 4 5 PupNurber 678 9 10 1 12 1 648662 7.40 8.50 7.20 8.30 2 7.60 6.80 6.80 6.90 6.40 7.80 7.50 sassare 646623 2 87.530077..1400 6.00 sasise & 646539 66..940066..3300 66..7300 65..8700 sase28a & 2 sassica & susseza & 646641 9 87..4900 76..0400 97..1800 76..8800 8.30 8.40 6.00 - 646572 9 65..0600 56..2100 64..0300 65..5400 646512 9.40 8.60 9.60 10.5 6.40 8.80 646566 1923.0199..2500 170..550 7.60 8.80 9 11729060 11.7 9.50 sass0a & 646602 & 10.111.411.9 cagseza & 9.10.60 646655 2 8.40 8.70 9.10 8.00 9.00 8.90 646663 2& 88.830087..3700 69..5500 79..8700 2 9608130880 6.30 6.10 646400 & eassrae &2 646532 9.105.01991.4700 1100..2678..0600 10.8 10.4 8.90 8.50 ET `Company Saniized. DoesnotcontainTSCA CBI 9H0-2-4D7a6y8:GaSvuabgeehrSotnuidcy iTnoxRiactistywithOne-Generation Reproduction Evaluations -~. IndividualLaPcutpatWieoinghDtasy (4grPaomsst)c:ullFiyngGeneration Group: 11-0 Dose: 0 mg/kg/day NAunmibmearl pSeuxp 1 2 3uupb4er5 6 1 646653 11.811.411.8 11.8 646575 1143.15 2103.1111049.21008 13.9127 130 13.2142 . Gassasa & 646622 10.6 11.3 10.6 10.0 646550 2 17.05.09171..602170..620 161..910 7.60 7.30 6.70 7.40 646526 15.515.015.1 15.4 14.8 646503 11431.91115401.1141037.4 14.3 sa66aa 1122.76 1151308 12.8 646604 9 91.24.041101..241111..241110..6810.9 10.4 11.1 646651 9 100..7910110.23 91.15.09 61.15.07 - ? 1.61107 1202 1201 664a6s6s05622 8 11.8 11.7 11.111.3 646557 1133..021121.0811130.005 1111.051 646591 1111711821116511111781111126 2 1009 12.a 1100 1106 646544 14.6 13.6 15.5 14.9 646646 ? 1113.00071.318011200.59 1140..30 10.19.00 5.50 8.90 6465200 8 646569 9.00 10.58.80 9.00 646654 91.12.08 81.25.01193..320 81.21.07 646668 ? 1112..611112..801122..90 1121..46 2 12.2120010.3 1005 DuPont. 5990 - > CompanySanitized. Doesnot containTSCA CBI 910.D24a7y68G:avSaugbeehSrtoundiyciTnoxRitcistywithOneGeneration Reproduction Evaluations Dupont5990 ~ IndividualLaPcutpatWieoinghDtasy (4grPaomsst)c:ullFiyngGeneration Group: 1-0 Dose: 25 ma/kgrday -- Mmber Sx 1 2 P3up Muanbser 6 7 646638 ? 1101..8391.05.041121.40191..640 646559 11232.1031l28.1421l10.1220133.7 Sasson 606561 & 16.217.116.1 16.4 16.5 16.5 . sassmia 3 15:2 606508 2 11.311.010.9 10.7 11.1 $ 100510051007 sassera 32 sasenna 6a6520 1z2.a91n2.n413a.713.212.9 646603 10.6118 10.6 9.90 - sasssaa 32 9.50 11.110.4 7.90 646573 5? 10.610.2 8.20 10.5 9.40 9.30 9.60 9.40 susseaa 3 646672 ? 1145.111155.5511050.501155.44 sassaaa 646543 32 14.015.114.0 646596 ? 1115.031141..3291.500 1113..68 12.0 2 110010.8 10.8 10.3 sagssea &2 sac6708 sa6ss3 &2 13.213.3 miswis12219 112 117 EE TE -- -- `Company Sanitized. DoesnotconTtSaCAiCnBI 9H0L-2D47a6y8G:avSaugbeehSrtoundiyc TinoxRiacittywithOneGeneration Reproduction Evaluations DuPont-5990 ~ Individual Pup Weights Lactation Day (grams): FP] Generation 4 Postculling Group: VI-0 Dose: 100 mg/kg/day M--imb--er --Sex 1 2 P3upNuamb5er 6 3 646547 2 190.4.07971.6100 88..6000 19.05.00 6assssa 2 646607 9.180..990 71.01.02 81.06.00 98..1600 6ass2aa &2 646600 $ 11101.61190..900 18.11.06 1110..46 646648 1162.4011340.09 12.5131 13.0 13.4 646594 ? 1130.5081121.321121.57 190..640 646586 5 1100.831100.291111.42 110.16 sasss1a &2 - 646671 89..640098..9700 81.06.028.80 10.0 Gass21 g9 1132.141121.39 127 7.80 11.2 12.2 6asso0a & 646645 ? 1121.641121.52 7153.03 1101.036 cassssa & sa6605a & sassesa & 6as6ls 1122.094112.2981133.101111.94 sags212 &2 646647 9.90 10.8 9.308.30 10.6 10.0 9.90 9.10 6assr5a & -- i - Company Sanilized.Doesnotcontain TSCA CBI 9H02-4D7a6y8:GavSaugbcehSrtoundiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPont5990 --_ IndividualLaPcutpatWieoinghDtasy (grams): Fy Generation 4 Postculling Group: VITI-0 Dose: 500 ma/kg/day Fr Number Sex 1 2 P3 upNu4mber5 6 1 646662 2 77..6400 68..8500 76..2800 87..3800 664a666s2a33a g& 8.30 7.40 7.50 7.10 6.00 , 6ase19e &2 646539 6.40 6.30 6.70 6.70 9 6.90 6.30 6.30 5.80 6a628a 666160 6asse3a 646641 2 87..4500 76..4000 89..3100 87..0800 - 646572 65..0600 65..1200 64..3000 65..5400 646512 2 89..3600 99..6200 71.05.05 8.40 8.80 646566 1112..2199..6500 10.5 11.7 8.80 9.50 6465708 8 646602 g 9 91.01.0191.16.0411.9 6ase2a & 646655 8.40 9.10 9.00 8.90 9 81808.30 9.50 9.70 646663 9 88.1330087..8700 66..5300 76..8100 666304 & assae 3 646532 9.70 10.6 10.8 8.90 2 9190 5.40 10.2 7.00 Is ~ CompanySanitized. Does notcontain TSCACBI 9H0-2-4D7a6y8:GaSvuabgcehrSotnuidcy iTnoxRiactistywith One-Generation Reproduction Evaluations DuPon-5990 _ Individual Pup Weights (grams): Fy Generation Lactation Day 7 Group: 11-0 Dose: 0 mg/kg/day ---- PupNumber Nimber Sex 1 2 3 4 5 6 97 646653 49 1198.1012107..001198..07 1199.056 646575 20.3 18.4 20.2 19.219.9 19.5 18.1 18.6 6acsesa & 646622 2 19.617.8 18.9 16.6. 646550 1172..531161.981171..59 111.71.6 646526 ? 2130.921213.7812020.89 2131.151 23.1 22.722.722.4 646503 2212..242139.832118..29 2221..23 646648 1197..3619.117.717.8 18.1 18.1 17.1 646604 16.9 18.6 18.1 19.7 64651 9 1198.70 1187.781718..14 1171.078 - 9 19.11801180117.1 664a666s0562a 8 17.8 18.5 18.9 18.1 646557 9 1188..181270..011260..911195..98 646591 9 201.81.1691.88. 1188..64 1198..35 646544 2138..182128..352230.080 2109.05s 646646 2 2120.0691270..432128..81 1195..83 2 15.316.6 15.4 14.3 6465208 8 646569 15.417.114.7 13.7 646654 ? 2105..242140..071231..821193..86 646668 1189..141199..432115..002200..32 . 9 19092001 16.7 17.7 Ti `CompanySanitized. DoesnotcontainTSCA CBI H902.4D7a6y8:GavSaugbeehSrtoundiyc iTnoxRaitcstywith One-Generation Reproduction Evalustions Dupont5990 --- Individual Pup WLeaicgthattsio(ngrDaamys)7: Fi Generation Group: 1v-0 Dose: 25 ma/kg/day ANnwibmearl 8pu%p 1 2 3PupNuambser 6 7 646638 4 1198.5711890.2811571.15 1196.63 646559 11991.13820046 2108.006 1179.037 , eassena 8 Guss6L g 222s.822.8 22.4 23.3 23.7 23.4 sassma 82 646504 $ 1166.3711670.901186..4317.117.6 6465872 & 646631 & 646529 $ 1184.197197.139190.5120.2 20.0 - 646603 1165.821185121 1175.77 1163..74 6465542 6a6579 35 17.317.5 17.7 13.9 1508 16la15.a 170 s64a6s6s7e2aa 3 22.623.6 24.1 23.8 2023322082305 646584a & 646543 1199.3811690.8522100.0820.219.8 64659 9 1155..001176.791177..271177..26 susssea saser0a 8 646553 ? 2109.1811281.01618.118.7 10.4 18.2 --- we `CompanySanitized. Doesnotcontain TSCA CBI H9-02.4D7a6y8:GavSaugbeehSrtoundiyc iTnoxRiactistywith One-Generation Reproduction Evaluations DuPont 5990 -- Individual Pup Weights (grams): Fi Generation Lactation Day 7 Group: VI-0 Dose: 100 mg/kg/day NAunmibmaelr PSeuxp 1 2 3tupun4 er5 6 1 646547 18.37.051124..33 1160.096 512..400 664a6c6e0s76a J 8.30 9.50 8.10 ? 10.77.70 * 6465282 82 646600 1151.:021185..20 1168..91 1186..47 646648 e 1178.471178.89 19.0 19.3 19.7 20.9 646594 9 1196.051194.8411790.517107.62 646546 ? 1177..5311660.75 1178..40 1156..96 - 664a6s6e7611a & 12.717.6 13.6 16521 ? 1185..571168.18815.312.3 13.0 1814181318.617.012.9 17.6 Ga6s90a & 646645 19.8 18.117.6 12.4 ? 17.218:217.3 1000 6465552 8 sas5052 & 664a666s1859a 8 17.320.520.6 20.4 20.0181619.a 19.8 Gags27a & 646647 15.316.915.715.216.317.3 ? 1.01500 6466750 8 Thar Company Sanitized. Does notcontainTSCA CBI 910.D24a7y68G:avSaugbechSrtouidcy iTnoxRiactistywith One Generation Reproduction Evaluations _ Individual Pup WLeaicgthattsio(ngrDaamys)7: Py Generation Group: vizz-o Dose: 500 mg/kg/day iBnuibpeerl 8To%p 1 2 P3up Nua4mberss 9 46662 $ 11.2 9.80 18.06.047.20 8.10 Sasser sas23f &e 70. caserse & 646535 5 65.16500 6.60 5.70 sase20a 3 saser6a 3 sasseia 32 64641 $ 72.670071.01.0198..1100 8.60 - 46572 5 6.00 6.10 4805.40 5.80 646512 1123..961122..4110.4 14.7 11.1 646565 ? n9..20az13s.16 0122.132100.85 sassr0a & 646602 1m6a.1n11a.9 14.0 sase2a 32 646655 $s 91.290975.500 646663 % 1115.0479..3500 1131..42 81.20.02 sassaod & sass7ae & 606532 4 2 1184.7311645315120.81 81.67.01 DuPon5990 _-- Tas CompanySanitized. Doesnotcontain TSCA Cal 9H0--2D47a6y8G:avSaubgcehSrtoundiyc iTnoxRiactistywith One-Generation Reproduction Evaluations DuPont5950 -- Individual Pup Weights (grams): Fi Generation Lactation Day 14 Group: TI-0 Dose: 0 mg/kg/day ANnuimmbaelr pSuepx 1 2 B3opSu4 ber5 6 1 646653 38.7 39.2 39.9 39.7 646575 3375..463378..783399..3440.0 9 36.538.835.4 35.6 37.6 sassusa 646622 ? 3376.1393358.02734600.50 3377..46 : 646550 g 32.0 32.1 32.7 32.9 646526 43030.95341313434030.61 4292.1.8 43.8 646503 4421..364431.79 4402.103 44.3 6a664a 9 3470.3439043706 4172 646604 9 3367..523398..85 3387..16 3379..24 37.8 37.3 36.9 646651 9 3358..942398..753386..403358..70 - 35.638.537.3 39.1 6465528 8 646606 38.3 39.5 37.4 37.4 646557 3356..983387..583358..99 3357..24 646591 9 4326.10934600.65 3436..16 4316..08 646544 3449.0014462.009423.980480.741.4 646645 g 4353..914304..37 43080.96 32890.00 2 33.633.333.435.5 6465208 3 646569 30.3 36.3 33.5 34.2 646658 9 3300330730.0 2900 80.5 41.4 42.4 41.5 381538.741.7 39.6 646668 9 4401..564412..463378..913481..21 na -- CompanySanitized. Doesnot conTtSaCAiCBnI 24768: Subchronic Toxicity 90-Day Gavage Study in Rats withOne Generation Reproduction Evaluations Dupont5990 - Individual Pup WLeaicgthattsion(grDaamys):14 Fy Generation Group: 1-0 Dose: 25 mg/kg/day fMinrber Sek 1 2 P3up Nu4mb5er & 7 646638 5 3382.0713338..853376..44 3378.098 6a6559 5 9 3386..953366..213368..30 3367..42 6ass90a 64sS61 5 4m2.e6 43.4 42.1 41.5 42.3'42.6 sass73a 646504 3 34.5 38.0 36.4 35.5 35.1 sassera & 36.836.333.8 2 6466312 646529 &25 39.837.3 39.9 40.5 40.5 646603 95 3367..063378..833356..43 35.2 - @ 31.2 34.034.3 37.8 6465542 646579 &23 35.4 31.9 36.4 35.1 32.935.433.6 3.4 6465642 3 646672 45.2 46.1 45.9 47.0 sasssaa 3 453 4aa62 02a 646543 37.7 38.6 39.0 616596 3379.14133060.66 3357..90 3373..66 33.4 320235033404 3408 6465588 J sas670a & 646553 g 3359..40348178 37.0 36.0 36.1 36.2 - ww `Company Saniized. Does not contain TSCA CBI H-24768: Subehronic Toxicity 90-Day Gavage Study in Rats withOneGeneration Reproduction Evaluations DuPont5990 --_ Individual Pup Weights (grams): Fi Generation Lactation Day 14 Group: VI-0 Dose: 100 mg/kg/day NAunmibmearl PSeuxp 1 2 3A4S5 6 1 646547 9 4211.6522.1 sas666a J . 6as607 8 6644666502040 8 37.430.0 38.8 35.1 646648 880..073387..7 2431.79 37.5 38.8 37.2 646594 2 4326..754328.80 42.6 40.4 646546 ? 3359..323440.1534.2 35.4 35.832.735.135.2 sase61a 8 646671 37.8 42.1 - 646521 9 3356..893387..0540.112.2 36.6 34.4 27.4 36.0 35.9 36.4 s64a6g6s49502 &2 36.237.9 38.6 35.935.635.8 16.2 sagsssa &2 sa6605a & 6a6589a & 646615 9 3396..173395..173388..95 3385..82 6644666542773 8 35.2 38.2 32.5 35.4 36.7 34.5 e 35.0329 sa6675a &2 es -- `Company Sanitized. Does not contain TSCA CBI H9-02-4D7a6y8:GavSaugbcehSrtourdiyc iTnoxRiactistywith One-Generation Reproduction Evaluations DuPont5990 =. Individual Pup Weights (grams): Fy Generation Lactation Day 14 Group: VITI-0 Dose: 500 mg/kg/day ---- PupNumber Number Sex 1 2 3 4 5 6 1 sas662e 8 sassa3a & sase23e 8 . sas619e & sags30e & sas628a & sase16a & sagseza & sassare & --_ sags72e &$ s64a6g5s616ze & 22.9 13.4 181170 sa65708 8 sdss02e sa6s820 8 sasesse 8 646663 9 2297..502216.096 26.9 16.2 6a66a0d 8 6saa6ess3728e 8 29.1 ? 25.319.4 11.7 - ww CompanySanitized. Doesnot contain TSCA CBI H-24768: Subchroric Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont5990 -- Individual Pup Weights (grams): Fy Generation Lactation Day 21 Group: 11-0 Dose: 0 mg/kg/day f------ PNupumber Mimbor Sex 1 2 3 4 5 6 1 646653 70.2 69.0 66.2 69.2 646575 9 6676.15366861.16 6529..02 68.7 64.962.7 61.9 66.6 61.5 sagsasa & . 646622 5597..085692..045577..38 6548..58 646550 59.9 60.7 57.9 59.4 646526 7562.1517527..015780..25 7512.056 74.1 646503 6699..696685..7477061.31 74.8 6a66aa g 752.05 .564.770.2 62.4 51.651.352.4 49.6 49.0 50.8 49.4 646604 62.5 61.2 57.9 145.757.4591 6518..77 - 646651 67.166.2 63.0 64.4 9 67.466.464.767.3 s64a6g6s0s62a & 59.8 62.9 61.8 56.3 646557 6598..915675..045659..115668..77 646591 6675..776636..176638..97 7614..75 646544 7659..296649..626731..846636..75 646646 9 4760..08 6633..80 5539..76 5659..17 48.454.455.354.2 6644665562902 & 53.4.57.555.9 55.0 646650 5638..844676..735637.404689..36 646668 96568..556702..886635..326683..1 9 9.164.265.5712 -- we `CompanySanitized. DoesnotconTtSaCAiC8n1 H902.4D7a6y8:GaSvuabgcehrSotnuidcy TinoxRiactistywithOne-Generation Reproduction Evaluations DuPont:5990 ~ Individual Pup WLeaicgthattison(gDraayms)2:1 Fy Generation Group: 1-0 Dose: 25 mg/kg/day . - BAunnibmaelr Speuxp 1 2 P3upNu4mber5 6 7 646638 9 6512.146590.0035594.665609.39 646559 9 59.8 65.7 59.661.3 6506..66 5605..71 sa6598a & 646561 7646.1473.170.2 72.5 73.0 71.1 sags730 & 645504 5 58.2'59.9 63.8 61.3 59.6 sagse7a & 571.759.2565 sase31a & 646529 &2 62.4 60.2 59.2 62.4 59.5 646603 &9? 5s84..525508..535672..90 63.1 6agssaa &9 63.456.051.955.9 646579 ? 57.152.654.3 58.7 6agseaa &? 52.752.553.253.6 646672 2 75.169.8 64.6 72.0 69.665.4.69.7 69.8 cusses & 646543 2 64.2 66.3 62.5 60.153.863.7 59.6 62.0 646596 &$e 6537..325573..785671..403650..96 casssea &2 saser0a & 646553 58.0545 48.250.6 52.1 46.5 48.3 48.9 Te`Company Sanitized. Doesnotcontain TSCA CBI 2904-7D6ay8:GaSvuabgcehrSotnuidcy TinoxRiactistywith One-Generaion Reproduction Evaluations DuPont5990 -- Individual Pup Weights (grams): Fy Generation Lactation bay 21 TT Gow vio Doser 0 monkey NJ inber Sex 1 2 P3up Nu4sb5er 6 7 65479 8 29.0 52.7 sas6s6a & 6466070 & . suss20a & 646600 & 61.164.7 49.5 57.4 646645 &9 6631.25 5688.8163630.68 60.6 59.5 58.8 646594 &9 7519..675658..09 68.3 71.1 648546 9 6557..03 4654..80 57.7 54.1 9 56.150.756.5 55.9 sass61a & 2 - 66671 9 6673..105629.58 64.2 646521 9 6573..925671..00 58.2 56.0 45.6 58.2 6asss0a & 646645 9 6631.756615..812648.11 62.0 eassssa 6ass0sa & s64a6s6s105a & 60.6 68.9 66.3 69.1 2 64.666.059.0 68.4 6s4a6s624772 &2 59.5 56.5 54.7 56.1 61.7 63.9 sase150 8? 54.956.9 2 - aw `CompanySaniized. DoesnotconTtSaCAiCnBI 9H0-2-4D7a6y8:GavSaugbeehrSotnuidcy TinoxRiactistywith One-Generation Reproduction Evaluations DuPont:5990 -- Individual Pup Weights (grams): Fi Generation Lactation Day 21 Group: VITI-0 Dose: 500 mg/kg/day Aiea Tig PupNumber Mimber Sex 1 2 3 4 5 6 7 6asesze & Gassaza 8 sagezse 8 sas619 & 6a6539 & 6466282 & 6466162 & 6a6s632 82 saseate & - sass728 sass128 646566 34.1 o 32.5282 6465702 &2 sas602 & 6a65820 & 6asesse 66663 38.338.0 40.3 2? 4214206 6466400 & Gsaas6ss72ae 8 27.9 9 18:3 Tis0Company Sanitized. Does not contain TSCA C8 H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats withOne-Generation Reproduction Evaluations DuPont:5990 APPENDIX HH REPRODUCTIVE TOXICOLOGY INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F, GENERATION - = `Company Sanitized. Does not contain TSCA C81 H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont5990 --- REPRODUCTIVE TOXICOLOGY INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F; GENERATION EXPLANATORY NOTES Footnotes a All pups were found dead on Lactation Day0. _-- `Company Sanitized. Does not contain TSCA CBI 'H9-02-4D7a6y8:GavSaugbcehSrotnuidcy TinoxRiactistywith One-Generation Reproduction Evaluations DuPont:5990 - INDIVIDUAL LITTER CLINICAL OBSERVATIONS: Fy GENERATION GROUP: II-0 DOSE: 0 MG/KG/DAY ANNUIMMBAELR LACTDAAYTION INsCtIoDnENCE OBSERVATIONS 646653 NO ABNORMALITIES DETECTED 646575 NO ABNORMALITIES DETECTED 646622 NO ABNORMALITIES DETECTED 646550 NO ABNORMALITIES DETECTED 646526 NO ABNORMALITIES DETECTED 646503 NO ABNORMALITIES DETECTED 646644 NO ABNORMALITIES DETECTED 646604 NO ABNORMALITIES DETECTED 646651 DAY 0 1100FF 1166 PPAARRTTIIAALLLLYY CCAANNNNIIBBAALLIIZZEEDD RRIIGGHHTT RREEAARR LPEAGW((SS)) DAY 4 PRE 110OFF 1166 PPAARRTTIIAALLLLYY CCAANNNNIIBBAALLIIZZEEDD TRAIIGLHT REAR LEG(S) --_ 11O0FF 1166 PPAARRTTIIAALLLLYY CCAANNNNIIBBAALLIIZZEEDD TRAIIGHLT REAR PAW(S) LITTER SBARY: 11 1 PPAARRTTIIAALLLLYY CCAANNNNIIBBAALLIIZZEEDD RRIIGGHHTT RREEAARR LPEAGW((SS)) PARTIALLY CANNIBALIZED TAIL 646606 NO ABNORMALITIES DETECTED 646557 NO ABNORMALITIES DETECTED 646591 NO ABNORMALITIES DETECTED 646544 NO ABNORMALITIES DETECTED 646646 NO ABNORMALITIES DETECTED 646569 NO ABNORMALITIES DETECTED 646654 NO ABNORMALITIES DETECTED 646668 NO ABNORMALITIES DETECTED - = CompanySanitized.Does notcontTSaCAiCnBI H-24768:Subchronic Toxicity 90-Day Gavage Study in Rats withOneGeneration Reproduction Evaluations DuPont5990 ~~ INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F, GENERATION GROUP: IV-0 DOSE: 25 MG/KG/DAY ANNUIMMBAELR LACTDAAYTION INsC1IaDnENCE OBSERVATIONS 646638 NO ABNORMALITIES DETECTED 646559 NO ABNORMALITIES DETECTED 646561 NO ABNORMALITIES DETECTED 646500 NO ABNORMALITIES DETECTED , 646529 NO ABNORMALITIES DETECTED 646603 NO ABNORMALITIES DETECTED 646579 NO ABNORMALITIES DETECTED 646672 NO ABNORMALITIES DETECTED 646543 NO ABNORMALITIES DETECTED 646596 NO ABNORMALITIES DETECTED 646553 NO ABNORMALITIES DETECTED - as Company Sanitized.Doos notcontTSaCAiCnBI H9-02-4D7a6y8:GavSaugbeehSrtoundiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPon-5990 - INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F, GENERATION GROUP: VI-0 DOSE: 100 MG/KG/DAY NAUNMIBMEARL LACTDAAYTION INCrIaDnENCE OBSERVATIONS 646547 NO ABNORMALITIES DETECTED 646607 NO ABNORMALITIES DETECTED 646600 NO ABNORMALITIES DETECTED 646648 NO ABNORMALITIES DETECTED 646594 NO ABNORMALITIES DETECTED 646546 NO ABNORMALITIES DETECTED 646671 NO ABNORMALITIES DETECTED 646521 NO ABNORMALITIES DETECTED 646645 NO ABNORMALITIES DETECTED 646615 NO ABNORMALITIES DETECTED 646647 NO ABNORMALITIES DETECTED - a= `CompanySanitized. Does notconTtSaCAiCnBI H9-02-4D7a6y8G:avSaubgcehSrtoundiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPont-5990 - INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F, GENERATION GROUP: VITI-0 DOSE: 500 MG/KG/DAY ANNUIMMBAELR LACTDAAYTION INsCzIoDnENCE OBSERVATIONS 646662 NO ABNORMALITIES DETECTED 646623 NO ABNORMALITIES DETECTED 646619 NO ABNORMALITIES DETECTED 646539 NO ABNORMALITIES DETECTED . 646641 NO ABNORMALITIES DETECTED 646572 NO ABNORMALITIES DETECTED 646512 NO ABNORMALITIES DETECTED 646566 NO ABNORMALITIES DETECTED 646602 NO ABNORMALITIES DETECTED 646655 NO ABNORMALITIES DETECTED 646663 NO ABNORMALITIES DETECTED sags70a 66532 DAY 21 1100FF22 WSETTAINPEEDRINPEEURMINEUM YELLOW 1lo0rF22 wLeEaTkHARGY LITTER SUMMARY: 11 11 WSETTAINPEEDRINPEEURMINEUM WLEEATKHARGY DAY 21 PUP DATA: PaUP: STAINED PERINEUM YELLOW WLEETTHPAERRGIYNEUM WEAK ------es Company Sanitized. Does not contain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations --_ DuPont5990 APPENDIX I REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS: F; GENERATION iT. `Company Sanitized.DoosnotconTtSaCAiC8n1 H9-02-4D7a6y8G:avSaugbcehSrtoundiyc iTnoxRiactistywithOne-Generation Reproduction Evaluations - REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHTS: Fi GENERATION EXPLANATORY NOTES Notes Day of weaning = Test Day 1 Footnotes a Sacrificed by design Test Day 15. b Sacrificbeyd design on Test Day 13. Found dead on Test Day 3. d Found dead on Test Day 5. e Found dead on Test Day 2. Abbreviations ~ = Noda. DuPont.5990 - a= Company Sanitized. Does not contain TSCA CBI H9-02-4D7a6y8G:SauvbacgherSotnuidcyTionxRiactistywith One-Generation Reproduction Evaluations DuPont-5990 - INDIVIDUAL BODY WEIGHTS (grams) OF Fy MALE RATS Group: T-1 DOSE: MG/KG/DAY onaTvEsST: ANIMAL NUMBER 664499999932 664499995553 664499939576 654499999989 665500000010 656500000023 665500000054 665500000076 650008 1 5 15 2 29 36 S6991.22 111028.52 117738.36 225421..03 332033..35 338584..47 S694054 19097073 1157931l7s 223198015 238028..92 335625..33 774481 112203028 119806.129 225544.60 331286..50 338906..90 6521075 11907016 117s5a..41 224265..67 321900..57 + 334760..78 5s6a.l3a 11958030 116s2o.l12 225228001 238179.005 3339270071 761877 11112807s 1178980.15 2J6a7.a8 33316.60 339852.66 5696..75 111002.64 116746..61 2233920090 320738..37 336299..19 6595..60 118673.30 113789.000 214370.52 324170.24 336064..18 681 115ls 17919 2446 306.3 367.7 - > __________ Company Sanitized. Donotecontsain TSCA C81 H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 - INDIVIDUAL BODY WEIGHTS (grams) OF F, MALE RATS Grove: TII-1 DOSE: 25 MG/KG/DAY onaTvEsST: ANIMAL NUMBER 665500000190 665500001112 665500001143 665500001165 665500001187 650019 1 5 15 2 2 36 S6501.19 1100530.70 116684..26 223340..33 229848..57 335328..68 5790016 11015614s 117867..66 22552982 332268.189 430903.166 6539.115 110011036 116604.64 222320.90 238031.11 33d6g0..e6 7S28070 110250.046 115580.83 226185..04 323782..32 4312070.16 6602l065 110032156 116670..27 223206..64 228963..18 334464..84 S45 107.2 167.4 233.8 295.5 354.7 Te CompanySanitized. DoesnotconTtSaCAiC8n1 H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont5990 ~~ INDIVIDUAL BODY WEIGHTS (grams) OF Fy VALE RATS Grou: v-1 DOSE: 100 MG/KG/DAY onDTAEYSST: 1 8 15 22 29 36 ANIMAL NUMBER 656500002220 5572..47 9812.75 116306..36 213946..80 229590..69 335069..50 665500002243 7s80l1s 11013431 116873.l10 225248.63 323806.111 a34161.l20 i 665500002256 6s2a0i8l 1100511s6 116701.28 221450.23 320722..55 336382..85 ` 665500002287 s5a7i0l0 1909l6s 1173321172 214s3s27 320563..73 3360570.77 665500003209 66390.51 11106336 116832.112 225301.33 230198..20 3356970.70 - he Company Sanitized. Doesnot contain TSCAC81 H9-02-4D7a6y8G:avSaubgeehSrtoundiyc TinoxRiactistywith One-Generaton Reproduction Evaluations DuPont 5990 ~~ INDIVIDUAL BODY WEIGHTS (grams) OF Fy MALE RATS Group: VII-1 DOSE: 500 MG/KG/DAY oNDTAeYsSt: 1 8 15 22 29 36 ANIMAL NUMBER 6500322 650035b 650036 30.1 68.0 165 = -- 40.3 7208 ee --- --- -- 27.9 es --- --- -- ---- Tie Company Sanitized. Does not contain TSCA CBI H24768: Subehronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 = INDIVIDUAL BODY WEIGHTS (grams) OF F, FEMALE RATS Group: 11-1 DOSE: 0 MG/KG/DAY onDTAEYSST ANIMAL NUMBER 665500004833 656500004456 656500004487 + 665500005409 665500005512 665300005543 565500005565 656500005587 650059 1 8 15 22 29 36 668L.57 111141.85 116519..28 113806..59 220113..14 222275..27 Ss2e0l6s 8s77..34 112284..42 115329.84 116798..94 210957..04 67020a3 1s2e3l0ss 11379211s2 11s399l6s 213s621.94 216904..79 548974 1s026l29 114374.32 116871.95 211867..31 223088..37 S676.73 esl0ls7 11s331l80 1178646 219101.10 221371..37 6634.s7 1s0e1l3s 1s3l8.s8 117746.041 210921.69 222144..51 s65a.z1 190370.31 a1503.0 1177990023 220010.14 22221.020 6438037 1s0l6s3 110190s7 114737014 1196591099 2118050.43 712 12203 17alo 21801 2449 26804 Tess Company Sanitized. Does not contain TSCA CBI F9-02-4D7a6y8:GaSvuabgcehrSotnuidcy TinoRxaitcistywithOneGeneration Reproduction Evaluations DuPont5990 - INDIVIDUAL BODY WEIGHTS (grams) OF F, FEMALE RATS GROUP: 1v-1 DOSE: 25 MG/KG/DAY onDTAEYSST: ANIMAL NUMBER 665500006610 665500006632 665500006654 656500006667 656500006689 650070 1 8 15 22 29 36 6590.73 m95l.s3 a13l3.l5 i16m3.i0 21874.18 215379.70 5666.151 11975073 113758.12s 126131.137 129305.198 221417.38 5575.99 1e0e1l0s 1133891111 117775..84 129070.00 220254..76 6593.68 10s5o0l0s 1182871.69 117771.64 220000.42 221271.69 36520090 896828 11337a.l16 117751..06 210964..60 222087..69 als s0l2 133l0 1766 203.8 227.1 Te `Company Sanitized.Doesnot contain TSCA C8 H-24768: Subchroric Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont5990 - INDIVIDUAL BODY WEIGHTS (grams) OF F, FEMALE RATS GROUP: VI-1 DOSE: 100 MG/KG/DAY onaTEsST: ANIMAL NUMBER 665500007733 665500007765 665500007778 665500007890 650081 1 8 15 22 29 36 5635.06 89981.05 112461..36 116802..05 128038..40 122906.98 S645.90 109230058 114501.58 118915..09 221313..92 224515..98 568422 1s060l0o5 11337.s6 117601.74 118992..17 221088..66 662.040 11$97..06 115504..35 118837..97 220245..01 223528..39 56.9 8301 1385 167.9 193.1 212.1 - us Company Sanitized. Doesnotcontain TSCA CBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 - INDIVIDUAL BODY WEIGHTS (grams) OF F, FEMALE RATS Grou: vITF-1 DOSE: 500 MG/KG/DAY onaTvESsT: 1 8 15 2 29 36 ANIMAL NUMBER 66550000886300 650087 28.62 ma --- --- ie.e --- 18.3 -- --- -- --- Ties CompanySanitized. DoesnotconTtSaCAiCBnI H24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 APPENDIX JJ REPRODUCTIVE TOXICOLOGY INDIVIDUAL BODY WEIGHT GAINS: F; GENERATION Te `CompanySanitized. Doos notconTtSaCAiCBnI 0F--2D4a76y8:GavSaugbcehSrtoundiyc TinoxRiactistywith OneGenersion Reproduction Evaluations --- REPRODUCTIVE TOXICOLOGY Dupor:5990 INDIVIDUAL BODY WEIGHT GAINS: Fy GENERATION EXPLANATORY NOTES Notes Day of weaning = Test Day I. Footnotes ba SSaaccrriiffiicceedd bbyy ddeessiiggnn ToensTteDstayDa1y5.13. Founddeadon Test Day 3. 4 Found deonaTedst Day 5. Found deonaTedst Day 2. Abbreviations = Nodata --- we Company Sanitized. Does notcontainTSCA CBI H-24768: Subehronic Toxicity 90.Day Gavage Study in Rats withOneGeneration Reproduction Evaluations DuPont-5990 - INDIVIDUAL BODY WEIGHT GAINS (grams) OF F, MALE RATS Group: 1-1 DOSE: 0 MG/KG/DAY onDTAEYSST: ANIMAL NUMBER 645499999932 664499999954 664499999976 564499999989 665500000010 665500000023 665300000054 666555000000000867 1-8 sels 15-22 22-29 29-36 1-36 @43l.30 eesias ml.) m6232 e51s2 32895.25 2 3905 ceoslias sessias caal7s eeslal 2390201.98 a4l6a7 6676.10 663.008 6714.54 6720.04 330261..19 aal6s e57a0s 7m126 6e5s0s 5660.30 320994..12 as2oll0s e6sgi2 7essis S619.04 47sl87 237362.047 l48o1 e6s6i3s 1695003 e7s0z5 s6e8l.s0 332133..09 aallss eelsor 7s5s1l3s edear e5s1i2s 326039.44 43621070 6472070 658625 6se3l.0 5557..94 22996.85 ls 643 647 617 ela 299.6 - ue `CompanySanitized. Doesnot conTtSCaAiCBnI 9H0--2D47a6y8G:avSaugbcehSrtoundiyciTnoRxaictistywithOne-GenerationReproduction Evaluations DuPont5990 - INDIVIDUAL BODY WEIGHT GAINS (grams) OF F, MALE RATS Grove: T11-1 DOSE: 25 MG/KG/DAY onaevsst: ANIMAL NUMBER 665500000190 656500001121 656500001143 656500001165 665500001187 650019 1-8 sels 15-22 22-29 29-36 1-36 4520.61 6621s6 6665..17 6s0e2a ss8o.1 2297771.59 aaliss 771112 9i6l2s 764907 7ea3l81 332a205 3a8l5ss 5683.38 6616..63 6710..12 6559..75 236051.17 a6l1s7 7s20l25 m5021 7360.38 755s.4 323686..19 @all0o esl8s2 eeslla? s6s7s. 6so0l7s 228816.29 5207 60.2 66.4 61.7 59.2 300.2 Te `Company Sanitized.Doesnot contain TSCA G81 H24768: Subchronic Toxicity 90-Day Gavage Study in Rats withOneGeneration Reproduction Evaluations DuPon-5990 a INDIVIDUAL BODY WEIGHT GAINS (grams) OF F, MALE RATS GROUP: V-1 DOSE: 100 MG/KG/DAY oNDTAEYSST: ANIMAL NOMBER 665500002220 665500002243 . 665500002265 665500002287 665500003209 1-8 81s 15-22 22-29 29-36 1-36 33581.38 6a7s6 7se.4s esaass 5s6.e9 225969..31 a1l4o5 eeellss 7el1l3s 7551158 06091 3238970.94 4472.088 6s5e1lss 6s9a.s0 6521.23 6660.03 32708.64.0 4a621l3s 63320017 eeseilss 6s3a5ss 5s9a.a0 3250010.76 34970.72 569559 6e8.e8 667..73 6409..50 229957..89 -- ETE Company Sanitized. Does not contain TSCA CBI 9H0--24D7a6y8G:avSaubgeehSrtoundiyc iTnoxRiactistywith One:Generation Reproduction Evaluations DuPont5990 - INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fy MALE RATS Group: VII-1 DOSE: 500 MG/KG/DAY oNDTAEYSST: ANIMAL NUMBER 6500322 6500350 650036 1-8 sls 15-22 22-29 29-36 1-36 33.9 48s 32.6 -- ee --- ------ -- - . - w --- See oo - po Te `Company Sanitized. Doss not contain TSCA Cal H9-02-4D7a6y8:GavSaugbcehSrtoundiyc iTnoxRiactistywith One-Gereration Reproduction Evaluations DuPon-5990 - INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fy FEMALE RATS Group: I1-1 DOSE: 0 MG/KG/DAY oNDTaesst: ANIMAL NOMBER 656500004434 665500004456 65500004487 665500005409 665500005521 665500005534 665500005565 666555000000555978 1-8 sels 15-22 22-29 29-36 1-36 4550..83 446870 3250.70 1260.65 2162..13 116557..70 2367 3a6l8i 3218a2 12600001 2260.56 114464.s2 5336041 sa0lls7 2270.043 322703s 213285 1135:0l.s4 aaslss aaslleo 33227 a19l0a6 2221060 115799063 a3sal0e 4a0lal 3263.l66 2d1a6s 22010.63 11e6d0.6d 33a8l20 a36llos 3305..66 2185..55 2212.065 116409.68 2390001 asillso 2a9l0s9 2221.22 12609819 117s8s.l09 432000s1 3:i23 33531067 2168ss 1154.54 114367..70 S11 517 aan 268 235 197.2 Tim -- `Company Sanitized. Does not contain TSCA CBI 9H0--2D47a6y8G:avSaubgeehrSotnuidcy TinoxRiactistywithOne-Generation Reproduction Evaluations DuPont-5990 - INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fy FEMALE RATS GRovR: 1-1 DOSE: 25 MG/KG/DAY onDaTEySsT: ANIMAL NUMBER 665500006601 665500006623 665500006654 665500006676 665500006889 650070 1-8 81s 15-22 2229 29-36 1-36 3166.80 3s8a.l2 4202.15 a2l1s8 21220.62 1173970.07 3s9i022 3s8ss 23821018 2273076 2101099 115a51.23 3sl1s 3a8l1s 336937 21350s2 235.76 116469.%7s 3278020 a7l0s3 2m8l8 2288s 1271.27 11648.00 3506.83 3as8i3a o3allas a20las 2123090 1134205719 a3 42s 36 212 233 m2 - wm Company Sanitized. DossnotconTtSaCAiCBnI 1H9-02-4D7a6y8G:avSaugbeehSrtoundiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPont.5990 - INDIVIDUAL BODY WEIGHT GAINS (grams) OF F, FEMALE RATS GROUP: VI-1 DOSE: 100 MG/KG/DAY. onaTvEsST: ANIMAL NUMBER 665500007730 665500007765 656500007787 665500007890 650081 1-8 81s 15-22 22-29 29-36 1-36 330a9 e 33103937 2253.45 1123.s8 1a5l7.s2 33899 awsls a40a2 3307033 23200060 11.908 337063 3 3sls 32200089 138170 21590095 114604..44 530066 3552s7 239044 23070.14 2383.83 11693..99 362 asia 2904 25.2 19.0 155.2 Tiss `Company Sanitized. Does not contain TSCA CBI 24768: Subchronic Toxicity 90.Day Gavage Study in Rats with OnGeeneration Reproduction Evaluations DuPont599%0 - INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fy FEMALE RATS GROUP: VIII-L DOSE: 500 MG/KG/DAY onDAmeYsSt: ANIMAL NUMBER, 650083 6500865 6s0087 18 sas sz 22-29 29-36 1-36 EE EE -- i `CompanySanitized. Doesnot containTSCA CBI H-24768: Subchroric Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont5990 APPENDIX KK REPRODUCTIVE TOXICOLOGY INDIVIDUAL FOOD CONSUMPTION: F, GENERATION im -- Company Sanitized. Does not contain TSCA CBI H902-4D7a6y8:GavSaugbcehSrtoundiyc iTnoxRiactistywith One- Generation Reproduction Evaluations DuPon-5990 --_ REPRODUCTIVE TOXICOLOGY INDIVIDUAL FOOD CONSUMPTION: F; GENERATION EXPLANATORY NOTES Notes Day of weaning = Test Day 1. Footnotes a Food consumption was inadvertently not measured on Test Day 1. b Sacrificed by design Test Day 15. Sacrificed by design on Test Day 13. d Found dead on Test Day 3 Found dead on Test Day 5. f Founddeadon Test Day 2. Abbreviations = Noda -ww Company Sanitized. Does not contain TSCA CBI HL24768: Subchronic Toxicity 90-Day Gavage Study in Rats withOneGeneration Reproduction Evaluations DuPont:5990 - INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fy WALE RATS Group: 1-1 DOSE: 0 MG/KG/DAY onaTvesst: ANTHAL NUMBER, 664499999932 664499999954 664499999976 649998 665409090909 665500000021 665500000043 665500000065 665500000087 18 sds 15-22 2229 29-36 1-36 1122.15 1290013 226635 22990.80 333035 2203..27 1123011 221106 2258007 2329.028 433813 22660030 n1l3ss 2200008 2276.34 23910s1 330s4 22840s7. 16 179 a 2205 2a 29.4 3226.078 2359.28 2p2o0t u1alss s2lss 2213.s3 2361007 2376.82 2261.63 11331 22020.24 2290a5 3291001 334386 2260.14 1122035 1198027 226002 2276.080 2381.88 2232..22 112084 119660 2205036 22730070 2289.84 21391011 1207 sls 246 27.2 317 2302 - ws `Company Sanitized. Does not contain TSCA CBI 2904-7D6a8y:GavSaubgcehSrtoundiyc iTnoxRiactistywith One-Generation Reproduction Evaluations DuPont5990 - INDIVIDUAL FOOD CONSUMPTION (grams/day) BY F, MALE RATS Group: TrI-1 DOSE: 25 MG/KG/DAY onaevsst: ANIMAL NUMBER 665500000190 665500001121 665500001134 665500001165 665500001187 650019 1-8 81s 1522 2229 29-36 1-36 1127s s18l.o3 228312s 22850.35 3261.08 22310.11 112213 22000025 2264016s 3226.s4 33.176 22350.19 1121027 sallss . 2223090 228527 3208.24 22030070 113227 2oa1si7s 22803a 32ssls 323231 2a5l0a6 11220s0 219100 2268.01 2298002 32290.06 2224.s9 --a 201 251 28.8 310 Sa TTiso- -- `CompanySanitized. DoesnotcontainTSCAC81 H9-02-4D7a6y8G:avSaubgeehSrtoundiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPont-5990 - INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fy MALE RATS Gop: V-1 DOSE: 100 MG/KG/DAY. onaTvEsST: ANIMAL NUMBER 665500002220 665500002234 + 665300002265 665500002278 665500003209 18 81s 15-22 22-29 29-36 1-36 ssl.s2 1155s3 21890.14 2292078 3253.21 218a.3 1m3l1s 2108078 2260l1s 32070030 3259.038 22523033 1Bl3a 11997s 22700s6 229a0l2s 3203037 220142 1u3s3 2sl3o a2s3s2 3240s 32270.83 2250.044 122076 129033 228a2 2n9l0ss 33220s7. 2s30hs Tee `Company Sanitized. Does not containTSCA CBI 9H02-4D7a6y8:GaSvuabgcehrSotnuidcyTionxRiactistywith One-Generaion Reproduction Evaluations Dupont599 - INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fy MALE RATS GRovP: vII-1 DOSE: 500 MG/KG/DAY onDmAeYSst Ana NomBER ss00320 ss0035 ss0036d 18 sas 1522 22.29 29.36 1-36 68 160 0 eee 89 o-oo oo SH -- Tw -- `CompanySanitzed.Does notcontTSaCAiCnBI H-24768: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5990 - INDIVIDUAL FOOD CONSUMPTION (grams/day) BY Fy FEMALE RATS Group: TI-1 DOSE: 0 MG/KG/DAY oNaTvEsST: ANIMAL NUMBER 665500004483 665500004456 665500004478 650049 665500005510 665500005532 665500005505 665500005576 665500005598 1-8 815 15-22 2229 20-36 1-36 B13I.5 2Il0e0 1291.52 2201048 22.142 119392 a 1100s5 a1s9i0a8 1is8l3e 21090030 2200001 1186..08 l18e7 l16ss 126.4 1a7l.a7 1270.11 21050s2 le 17 ssa 17s 187 205 12720.04 1260.6 0 aa ss 11030.70 1702ls 1I6s7o 1206099 128125 1158..54 u2z7 m1l1z 120s06 210758 211920 1168..94 127s 1172s 118s0 11970.58 2108046 1177..40 usll?s 11323 119928 1168.44 1178.46 1175010 181 2006 23s 2208 236 2102 Tis `CompanySanitized. Does not contain TSCA Cal H9-02-4D7a6y8G:avSaubgcehSrtoundiyc TinoxRiactistywithOne-Generation Reproduction Evaluations DuPont-5990 - TNDIVIDUAL FOOD CONSUMPTION (grams/day) BY F, FEMALE RATS Grove: TV-1 DOSE: 25 MG/KG/DAY onDATEYSST: 1-8 sas 1522 22-29 29-36 1-36 ANIMAL NOMBER 665500006610 1s0l.s8 1157.79 126107 124637 2154.39 a15l.0 : 665500006623 650064 112l7s 210607 i2s2a6 1290ss 211952 2107a1 1208 els 1s 188 193 17.3, 665500006656 182020 11562s 1198l2s 119870 2171.6 116658 665500006687 1u0ls iisslies i1s7i0ss 1188s1 1188a2 1le63 650069 1008 164 2000 22.2 238 1s.e 650070 a 161 199 203 2107 a Tiss `Company Sanitized. Doesnotcontain TSCA CBI 9H0L2-4D7a6y8:GaSvuabgeehrSotnuidcy TinoxRiactistwyith One-Generation Reproduction Evaluations DuPont. 5990 - INDIVIDUAL FOOD CONSUMPTION (grams/day) BY F, FEMALE RATS Grove: VI-1 DOSE: 100 MG/KG/DAY. onaTvEsST: ANIMAL NUMBER 665500007743 665500007765 665500007787 665500008709 650081 1-8 sls 15-22 2229 29-36 1-36 109.39 1167.4 1169l.s6 1197.33 210895 115173.4 121le 1r7lss 2129070 2201023 2203010 21080s0 l9o7 sisllae 11881s 11970.51 119703 1a6s.s7 1l3oll8s 11871s 12080s5 12250030 220a07 1198:12 mz owls 181 sla 188 16.7 -- Ts Company Sanitized. Doesnotcontain TSCA CBI H902.4D7a6y8:GavSaubgcehSrtourdiyc iTnorRiactistywith OnGeeneration Reproduction Evalutions Dupont59%0 -~ INDIVIDUAL FOOD CONSUMPTION (grams/day) BY F, FEMALE RATS Grove: vIII-1 DOSE: 500 MG/KG/DAY onDaTeysst. ANIMAL NUMBER 6565000088630 ss0087 18 eas 1522 22-29 29-36 1-36 80 em we mem eee em -- Te `CompanySanitized. Doesnot containTSCA CBI H9-02-4D7a6y8:GavSaubgcehSrtourdiyc iTnoxRiactistywith One-Generation Reproduction Evaluations DuPont5990 APPENDIX LL REPRODUCTIVE TOXICOLOGY INDIVIDUAL CLINICAL OBSERVATIONS: F; GENERATION Te `Company Sanitized. Does not contain TSCA CBI H9-02-4D7a6y6:GavSaugbcehSrtoundiyc TinorRiacittywith One-Generation Reproduction Evaluations - REPRODUCTIVE TOXICOLOGY DuPont-5990 INDIVIDUAL CLINICAL OBSERVATIONS: F; GENERATION EXPLANATORY NOTES Notes Day of weaning = Test Day 1. --_-- Tw Company Sanitized. Does not contain TSCA CBI H9-02-4D7a6y8G:avSaubgcehSrtoundiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPont5990 - INDIVIDUAL CLINICAL OBSERVATIONS IN , MALE RATS GROUP: T-1 DOSE: 0 MO/KG/DAY Am ome OBSERVATION OFBISRESRTVEDDAY LOABSSTERDVAEYD 649952 SPARCERPIUFTIIACLEDSBEYPARDAETSIIOGNN TCEOSMTPLEDTAEY 40 645993 SPARCERGIUPTIIACLEDSBEYPARDAETSIIOGNN TCEOSMTPLEDTAEY 40 . 64999 SPARCERPIUFTIIACLEDSBEYPARDAESTIIGONN TCEOSMTPLEDTAEY 40 649995 SPARCERPIUFTIIACLEDSBEYPADREASTIIGONN CTEOSMTPLEDTAEY 40 645996 SPARCERPIUFTIIACLEDSBEYPARDAETSIIOGNN CTOEMSPTLEDTAEY 40 649957 SPARCERPIUFTIIACLEDSBEYPARDAESTIIGONN CTOEMSPTLEDTAEY 40 649998 SPARCERPIUFTIIACLEDSBEYPADREASTIIGONN CTEOSMTPLDEATYE 40 645995 SPARCERGIUFTIIACLEDSBEYPARDAETSIIOGNN CTEOSMTPLEDTAEY 40 650000 SPARCERPIUFTIIACLEDSBEYPARDAESTIIGONN CTEOSMTPLEDTAEY 40 650001 SPARCERPIUFTIIACLEDSBEYPADREASTIIGONN CTEOSMTPLDEATYE 40 650002 SPARCERPIUFTIIACLEDSBEYPADREASTIIGONN CTOEMSPTLDEATYE 40 650003 SPARCERGIUFTIIACLEDSBEYPADREASTIIGONN CTOEMSPTLDEATYE 40 650004 SPARCERGIUFTIIACLEDSBEYPADRRASTIIGONN CTOEMSPTLDEATYE 40 650005 SPRAECPRUITFIIACLEDSBEYPADREASTIIGONN CTOEMSPTLDEATYE 40 650006 SAPLAROCEPRFEIUCFTIIIAACLEBDOSTBEHYPADRFEARSTOIINGOTNNPTCAOE(MSSPT)LEDTAEY 40 650007 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN CTOEMSPTLEDTAEY 40 650008 ESARCERPIUFTIICAELDSBEYPADREASTIIGONN CTOEMSPTLEDTAEY 40 26 2 2s 2 2 2 . 2 2 2 2 2 =n = = 2 2 26 26 2 2 2 2 2 2s 26 2 2 2 326 "20 2 = 2s 2 Tie `Company Sanitized. Doss not contain TSCA C81 9H0L-2D4a7y68G:aSvuabgeehrSotnuidcy TinoxRiactistwyith OneGeneration Reproduction Evaluations DuPont-5990 -- INDIVIDUAL CLINICAL OBSERVATIONS IN F: MALE RATS GROUP: III-1 DOSE: 25 MG/KG/DAY mo EER 650009 650010 650011 650012 650013 650014 650015 650016 650017 650018 650019 oasRvaTION `PSRAECFRUITFIIACLEDSBEYPADREASTIIGONN CTOEMSPTLDEATYE 40 SPARCERPIUFTIICAELDSBEYPARDAETSIIOGNN CTEOSMTPLEDTAEY 40 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN CTBOSMTPLEDTAEY 40 SPARCEREIUFTIICAELDSBEYPADREASTIIGONN CTOEMSPTLDEATYE 40 SPARCERGIUFTIICAELDSBEYPADREASTIIGONN TCEOMSTPLDEATYE 40 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN TCEOSMTPLDEATYE 40 SPARCERPIUFTIICAELDSEBPYARDAETSIIOGNN TCEOSMTPLDEATYE 40 SPARCEREIUFTIICAELDSEBPYARDAETSIIOGNN TCEOSMTPLDEATYE 40 SEARCERPIUFTIICAELDSBEYPADREASTIIGONN TCOEMSPTLEDTAEY 40 SPARCERFIUFTIICAELDSEBPYARDAETSIIOGNN CTOEMSPTLEDTAEY 40 SBARCERFIUFTIIACLEDSEBPYARDAETSIIOGNN CTOEMSPTLEDTAEY 40 OFBISRESRTVEDDAY 2 2 2 2 26 26 2 2 26 2 2 OLBASSETRDVAEYD 2 2 2 2 26 26 zn 25 26 2 = Tio Company Sanitized. Does notcontainTSCA CBI H-24768: Subehronic Toxicity 90.Day Gavage Study in Rats withOneGeneration Reproduction Evaluations DuPont 5990 - INDIVIDUAL CLINICAL OBSERVATIONS IN P, MALE RATS GROUP: V-1 DOSE: 100 MG/KG/DAY ADA NBER oBsERvATION FOIBRSSETRVEDDAY LGBASSETRVDEADY 650020 SPARCERPIUFTIICAELDSBEPYARDAETSIIOGNN TCEOSMTPLEDTAEY 40 650022 SPARCERPIUFTIICAELDSEBPYARDAETSIIOGNN TCEOSMTPLEDTAEY 40 650023, SPARCERPIUFTIICAELDSBEPYARDAETSIIOGNN CTEOSMTPLEDTAEY 40 650024 SBARCERPIUFTIIACLEDSBEYPARDAETSIIOGNN CTEOSMTPLEDTAEY 40 650025 SPARCERPIUFTIICAELDSBEYPARDAESTIIGONN CTOEMSPTLEDTAEY 40 65006 SPARCERPIUFTIICAELDSBEYPARDAETSIIOGNN CTOEMSPTLEDTAEY 40 650027 APLROEPPEUCTIIAALRISGEHPTARAFTRIOONNT CPOAWM(PSL)ETE SACRIFICED BY DESIGN TEST DAY 40 - 50028 SPARCERPIUFTIIACLEDSBEYPARDAETSIIOGNN CTOEMSPTLDEATYE 40 650029 SPARCERPIUFTIIACLEDSBEYPARDAETSIIOGNN CTOEMSPTLEDTAYE 40 650030 SPRAECPRUITFIIACLEDSBEYPARDARTSIIOGNN C1O2MSPTLDEATYE 40 EF 20 FH 2 2 26 2 2 2 2 El El 025 "205 = =n 2 2 2 2 Tor CompanySanitized. Doesnot conTtSaCAiGanl H9-02-4D7a6y8G:avSaugbehrSotnuidcy TinoxRiactistywith One-Generation Reproduction Evaluations DuPont:5990 - INDIVIDUAL CLINICAL OBSERVATIONS IN Fi MALE RATS GROUP: VII-1 DOSE: 500 MG/KG/DAY ANTAL woEER oBsERvATION OFBISRESRTVEADY LGABSSTERDVAEYD 650032 NSoACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 15 650035 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 13 650036 NFOOUANBDNODREMAADLITTEISETSDDAYETE3CTED . Tie `Company Sanitized. Doas not contain TSCA CBI H24768: SubchronicToxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont5990 - INDIVIDUAL CLINICAL OBSERVATIONS IN : FEMALE RATS GROUP: TI-1 DOSE: 0 MG/KG/DAY ADL EER OBSERVATION OFBISRESRTVEDDAY OLBASSETRDVAEYD 650043 VSAAGCIRNIAFLICEPDATBEYNCYDECSOIMGPNLTEETSET DAY 40 650044 VSAAGCIRNIAFLICEPDATBEYNCYDECSOIMGPNLTEETSET DAY 40 650045 SVAACGRDIAFLICEPDATBEYNCYDECSOIMGPNLTEETSET DAY 40 650046 VSAAGCDRWIAFLICEPDATBEYNCYDECSOIMGPNLTEETSET DAY 40 650047 V`SAAGCIRNIAFLICPEADTEBNYCYDECSOIMGPNLTEETSET DAY 40 650048 SVAAGCIRNIAFLICEPDATBEYNCYDESCIOGMNPLETTEEST DAY 40 650009 SVAAGCIRNIAFLICEBDATBEYNCYDESCIOGMNPLETTEEST DAY 40 650050 SVAAGCIRNIAFLICEPDATBEYNCYDECSOIMGPNLETTEEST DAY 40 650051 VSAAGCIRNIAFLICEPDATBEYNCYDESCIOGMNPLETTEEST DAY 40 650052 VAALGOIPNEACLIABBAOTTEHNCYFROCNOTMPLPEAWT(ES) SACRIFICED BY DESIGN TEST DAY 40 650053 SVAAGCIRNIAFLICEPDATBEYNCYDESCIOGMNPLETTEEST DAY 40 650054 VSAAGCIRNIAFLICEPDATBEYNCDYECSoImGpNLETTEEST DAY 40 650055 VSAAGCIRNIAFLICEPDATEBNYCYDECSOIMGPNLTEETSET DAY 40 650056 SVAAGCIRNIAFLICEPDATBENYCDYECSOIMGPNLTEETSET DAY 40 650057 VSAAGCIRNIAFLICEPDATBEYNCDYECSOIMGPNLTEETSET DAY 40 650058 SVAAGCIRNIAFLICEeDATBEYNCDYECSOIMGPNL1E2TSET DAY 40 650059 VSAACGRIINFAILCEPDATEBYNCYDECSOIMGPNLTEETSET DAY 40 s s 5 5 0 1 1 n s 5 un u 15 1 1 1 n n 55 2 1 1 1 1 5 s 2 12 n n 10 10 5 s Tess CompanySanitized. Doesnot containTSCA CBI H-24768: Subchroic Toxicity 90-Day Gavage Study in Rats withOneGeneration Reproduction Evaluations DuPont-5990 - INDIVIDUAL CLINICAL OBSERVATIONS IN Fy FEMALE RATS GROUP: Tv-1 DOSE: 25 MG/KG/DAY mA EER oBsERvATION FOIBRSSETRVEDDAY LOBaSsE?RVDEADY 650060 VSAAGCIRNIAFLICEPDATBEYNCYDECSOIMGPNLTEETSET DAY 40 10 0 650061 VSAAGCIRNIAFLICEPDATBEYNCYDECSOIMGPNLTEETSET DAY 40 un n : 650062 VSAAGCIRNIAFLICEPDATBEYNCYDECSOIMGPNLTEETSET DAY 40 n n . 650063 VSAAGCIRNIAFLICEPDARBEYNCYDECSOIMGPNLTEETSET DAY 40 15 1 650064 SVAAGCIRNIAFLICEPDATBEYNCYDECSOIMGPNLETTEEST DAY 40 1 1 650065 VSAAGCIRNIAFLICEPDATBEYNCYDECSoIwGPNLETTEEST DAY 40 5 . 650066 SVAAGCIRNIAFLICEPDATBEYNCYDESCIOGMNPLETTEEST DAY 40 1s 15 650067 VSAAGCIRNIAFLICEPDATBEYNCDYECSOIMGPNLETTEEST DAY 40 650068 VSAAGCIRNIAFLICEPDATBEYNCDYECSOIMGPNLETTEEST DAY 40 2 12 12 n 650063 VSAAGCIRNIAFLICEPDATBRYNCDYECSOIMGPNLETTEEST DAY 40 n n 650070 SVAAGCIRNIAFLICEPDATBEYNCDYECSOIMGPNLTEETSET DAY 40 n n Toa Company Sanitized.DoesnotconTtSaCAiC8nI F9-02-4D7a6y8G:avSaubgcehSrtourdiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPont5990 -~ INDIVIDUAL CLINICAL OBSERVATIONS IN Fy FEMALE RATS GROUP: VI-1 DOSE: 100 MG/KG/DAY ANTAL NOMBER oBsERVATION OFBISRESRTVEDDAY LGABSSTERDVAEYD 65007) VSAAGCIRNIAFLICEPDATEBNYCYDECSOIMGPNLTEETSET DAY 40 1 1 650074 VSAAGCIRNIAFLICEPDATEBNYCYDECSOIMGPNLETTEEST DAY 40 1 5 650075 VSAAGCIRNIAFLICEPDATEBNYCYDECSOIMGPNLETTEEST DAY 40 . 1 1s 650076 VSAAGCIRNIAFLICEPDATEBNYCYDECSOIMGPNLTEETSET DAY 40 2 2 650077 VSAAGCIRNIAFLICEPDATEBNYCYDECSOIMGPNLTEETSET DAY 40 10 10 650078 VSAAGCIRNIAFLICEPDATBEYNCYDECSOIMGPNLTEETSET DAY 40 10 10 650079 VSAAGCIRNIAFLICEPDATEBNYCYDECSOIMGPNLTEETSET DAY 40 650080 VSAAGCIRNIAFLICEPDATEBNYCYDECSOIMGPNLTEETSET DAY 40 13 1 s 650081 VSAAGCIRNIAFLICEPDATEBNYCYDECSOIMGPNLTEETSET DAY 40 5 s Ts Company Sanitized. Does not contain TSCA CBI H902-4D7a6y8:GavSaugbeehSrtoundiyc TinoxRiactistywith One-Generation Reproduction Evaluations DuPon-5990 ~~ INDIVIDUAL CLINICAL OBSERVATIONS IN Fy FEMALE RATS GROUP: VITI-L DOSE: S00 MG/KG/DAY ANIMAL NOMBER oBsERvATION OFBISRESRTVEDDAY 1GSBSTERDVAEYD 650083 FNOOUANBDNODREMAADLITTEISETSDADYETE5CTED 650086 VSAAGCIRNIAFLICEPDATEBNYCYDECSOIMGPNLTEETSET DAY 13 650087 SWETTAINPEEDRINPEEURMINEUM YELLOW LFEEORTUKHN.ADRGDYEAD TEST DAY 2 n un 11 11 11 11 - ws. Company Sanitized. Does not contain TSCA CBI