Document J3yjgbVNDw8nyaEbey70Y8D06

From: Sent: To: Cc: Subject: Bruce Jarnot <jarnotb@api.org> Wednesday, April 6, 2005 7:13 PM (GMT) Bruce Jarnot <jarnotb@api.org>; benzconsort-tc@listserve.api.org Lorraine Twerdok <Twerdokl@api.org> SHS ... 2nd FYI: Other items for budget reanalysis FYI, for budget reanalysis discussion on Friday's TC call (excerpt from Rob Schnatter email) ... SHE items being checked by Rob Schnatter, to determine 1) whether they are currently covered on a SHS budget, and 2) if not, which is the most appropriate budget to include item. > "Tom -- Since Rich, Otto and EMBSI (I believe) have requests for additional > funding on the table already, I think that this last request needs to look > at whether there are any gaps in what the three of us have considered. > (Assume that this has also been broached from Fu/XiBiao's perspective?) > > I believe there are a few possible areas to consider: > > (a) Additional EA help. I still believe we are short-staffed for > on-the-ground help in Shanghai. In the recent staff meetings that I > attended at Fudan, it seemed that the ME phase1 EA activities slowed > progress for CC/DP EA activities and vice versa. It would be nice to have > two dedicated teams, perhaps with two 'sub-leaders' (under XiBiaoNimei). > This will only get worse when phase 2 starts up again. I thought 3-4 more > persons would be appropriate, but Yimei and XiBiao would be able to assess > this better. I still beleive a 'factory laison' person is needed .. don't > know whether all of this is in Rich's budget request. (Rich?) > > (b) Addtional support from Dr. Ni. He has been excelent in terms of > identifying factories for ME, but there are still issues that need to be > worked with him. One such issue is that medical exams for 'normals' may be > stored in different places than medical exams for 'abnormals'. This needs > to be tested thoroughly. Also, more factories need to be recruited, and it > is my understanding that his contract was finished in March. (Rich to > verify). I belive we need Dr. Ni through 2006. > > (c) As you mention, additional EA 'expert' help. As we seem to be leaning > toward a job/sector (or JEM) approach, additional reviewers such as Jack > Siematycki (who has turned the JEM into a science), Coble, as you mention, > Vermuillen, etc. I appreciate that we have EA skills on the SRP, but more > on the ground review may be needed, especially for the CC/DP study. You SH ELL-MCCLU RG-052550 > would be the person to decide scope/amount. > > (d) Incentive payments to factory managers, district IPHS offices, etc. to > get things done (i.e. to offset interfeernce in their regular work > routines). (Rich needs to verify whether existing budget adequately > covers this). > > (e) Otto would be the best person to address the power issue on the CC/DP > side. On the ME side, the lower than expected prevalence of Bz exposure > has certainly increased the effort required to recruit factories. > > (f) (BTEX): Regarding ME phase 1 only, we estimated that an additional 70K > would be needed to analyze T and X as well as Bz. If we want to make T and > X a focus of phase2, much more work is needed, especially if we want to > analyze compound-specific metabolites ... You and Otto ought to consider the > scope needed to elevate focus on T and X in CC/DP. > > Finally, I assume that the technical committee has asked Fu this very > question (e.g. last chance for budget increase). Michael - please verify. > If not, do you want our team to coordinate this with our Chinese > colleagues?? > > Rob > > A. Robert Schnatter > Senior Scientific Advisor > ExxonMobil Biomedical Sciences, Inc. > Room LF-246 > 1545 Route 22 East > Annandale, NJ 08801-0971 > 908-730-1101 -----Original Message----From: Bruce Jarnot Sent: Wednesday, April 06, 2005 3:07 PM To: 'benzconsort-tc@listserve.api.org' Cc: Lorraine Twerdok Subject: SHS ... FYI: confirming EMBSI budget reanalysis FYI. .. for budget reanalysis discussion on Friday's TC call. -----Original Message----From: a.r.schnatter@exxonmobil.com [mailto:a.r.schnatter@exxonmobil.comJ Sent: Wednesday, April 06, 2005 12:38 PM To: Bruce Jarnot Subject: budget issues. SHELL-MCCLURG-052551 Bruce - regarding your voice mail -- I am working this from two perspectives: our existing budget request and also exposure assessment activities that may have fallen through the cracks fo existing budget requests. Regarding EMBSI, our request of 884K is still likely to be OK. Regarding the second item, some needed activites do not appear to be in anyone's existing budget: e.g. an extension for Dr. Ni, who is instrumental in identifying ME factories, and perhaps expected payments to those factories. We are waiting for some answers from Yimei on certian items -will try to get you numbers around any addtional considerations by end-of-week. Regards, Rob A. Robert Schnatter Senior Scientific Advisor Exxon Mobil Biomedical Sciences, Inc. Room LF-246 Route 22 East Annadale, NJ 08801-0971 908-730-1101 908-730-1192(fax) SH ELL-MCCLU RG-OS2SS2