Document J3gZdngejpooY9em9vd3RBpwr

1181 [Jnn. IS. \*T>' toxicology 11445-1145* ENVIRONMENTAL AND INDUSTRIAL TOXICOLOGY also: Puhllr Hrslih - Occupational Health, Radiation Health f 11445, JONES. R. D. (Pham. DW,, l. C. I. Ltd., Alderley Part, Macclesfield, Cheshire, EngL, UKJ, B. T, COMMINS and A. A. CFRNDC. Blow! lead and c.irbosThaemogicibtn levels In London taxi drivers^ LANCET (NORTH AM EOF 2(7772): 302-303. 1972.--Among SO London tixt drivers the mean blood-lead mas 28.7 up/100 ml. There was an difference of statistical alpnlflcance In the blood-levels of smokers and non-smokers, nor betseen the blood-leads of nlcht-shift and dav-shlft drivers. Carbosvhemoplobla levels of smokers ere sicniflcantly Metier K-an those of non-smokers, and the levels were significantly higher 0. day drivers than In night drivers, f 11446. MC INTIRE, MATILDA S. and CAROL R. ANCLE. (Dep. Pedlatr.. Unlv. Nebr, Colt. Med,, Omaha, Ncbr* 68105, USA.) Air lend: Relation to lead in blood of black school children deficient in glucose-6-phosphate flehvdrocenase. SCIFNCE (WASH) 177(4048): 526-522. Ulus. 1972.--Black children (44) at 2 elementary schools within 0.7 mi of a battery plant had sicniflcantly higher (P<0.01) concentrations of Pb In thetr bloods (34.1 + 9.7, pg/lOOmm, mean + SD) than 122 students (26 J * 7.1) at 7 schools 1-3 ml distant; 5 mo, later there was a comparable difference between red cell Pb values (54.1 18.5 vs. 37.4 * 12.6). Among the blacks, those deficient In gJueose-6-phosohateDehydrogenase had a higher (P<,005) concentra tion of Pb in the blood after correction for anemia (32.9 * 9,7) than the nondeltctent (25.7 - 8 J), and a higher concentration in the red cells (47J ^ 14.7 as compared to 35,6 * 15.8 P< .001); the enzyme eflect was independent of geographic location. T 11447. MARKOWITZ, SAUL S., CHARLES J, MC DONALD (Roger Williams Gen. Hosp., 8)5 Chalkstone A,e., Providence, R, I. 02908, USA.). ..'TLUAM FEY" ntRE and MARVIN S. KERZNER. Occupational acroosteolvus, ARCH DERMATOL 106(2): 219-223. [Hus. 1972,-- Occupational acroosteoly'ts is an unusual disease in which affected persons have scleronernoid-bke lesions of the skin, conditions similar to Raynaud's phenomen n, and asymptomatic, bony defects of the extremities. Evidently, tne disease Is confined solely to workers in the plastics industry, specifically those engaged in the production of polyvinyl chloride ITM vinyl chloride. The Incidence of the disease is unknown but Is thougt. to occur in Z% or less of workers, f 11441', WILDISH, D. J, 'Fish, Res, Board, Can. Biol. Stn., St. Andrews, N. B,, Can.) Acute toxicity of polyoxyethylene esters and polyoxyethylene ethers to 5, salar and G, oceanicus. WATER RES 6(7): ,?59-762, Ulus. 1972,--Polyoxyethylene ethers are more toxic to aquatic fauna than polyoxyethylene esters. Polyoxyethylene (4) lauryl ether Is 9 times more toxic than polyoxyethylene (14) monolaurate at the ILL [Incipient lethal levels] to Salmo salar and 14,000 times more toxic at the 96-hr LC50 [lethal concentration median] to Gammarus oceanlcus Sergestrale. t 11449. HOFMANN, A. (Inst. Toxlkol., E, Merck Darmstadt, D-8100 Darmstadt 2, West Ger.) and M. NEUFELDER. Tierexperimentelle Untersuchungen xur gewerbetoxikologisehen Beurteilung yon 2-chloraethylisocyanat. (An invest! ratinn of 2-ehloroethyl Isocyanate In laboratory animals wun regard to one unpllcatinns as a potential occupational hataid7[ ARCH TOXIKOL 29(i); '53-84, lllus. 1972. [Engl. suram,|--The acute oral toxicity of 2-ehloroethyl Isocyan ate (CAIC) is 396 rag/kg for male rats and 630 mgAg for female mice. Hie extremely small Quantity of 5 pi CAIC caused severe irritation in the eyes of rabbits, particularly of the conluncttva. The skin was also affected considerably. Inhalation experiments. Involving a new version of a proven method for generating air-vapor mixtures, pro duced no evidence of systemic toxicity, but let CAIC be classified as an irritant vapor to the respiratory tract. The LC$o (or rats is 6 J ppm after expoeure for 8 hr, while rats In 2 experiments involving 10-day exposures to vapor concentrations of 3.1 and 3.8 ppm, respec tively, survived. After a fortnight's withdrawal following each experi ment, histological examinations showed tracheobronchitis and bronchofxieumonia but no pathological change In any other organ examined. A threshold limit value (TLV) of 0.02 ppm was suggested. t 11450. JOSE, FRANCISCO R, (Dep. Physiol. Hyg. Nutr,, Unlv. Philipp., Manila, Philipp.) A study of lead hazard In some lead process ing Industries. ACTA MED THILIPP 8(2): 48-54. 1972.--Two bat- " tery plants, 2 paint establishments and X company manufacturing lead oxide were studied to evaluate the extent and Intensity of Pb haxard. Methods of evaluation used were levels of Pb In air, and urinary Pb, stippled red cell count and clinical manifestations suggestive of Pb Intoxication among employees in the establishments. Levels td Pb in sir, Pb concentration in the urine and stippled red cell count wers Higher In the lead oxide and battery plants than in those engaged In paint manufacturing. Clinical manifestations sugrestive of Pb poisoning were also mors frequent. Good correlation was observed between the laboratory findings and the clinical manifeatntiau maleshve at mild Pb poisoning. t 11451, GOODWIN, JOHN W. (Day, Zlmmermann, Inr., Ixne 3.ir Dlv., Texarkana, Tex. 75501, U5A.) Twenty yeirs hmdlmr TNT in a a hell loading pi ^ AM tND HYG ASSOC j .l3<lT"Tl-44* IlM*. T972>-In the hanriTlni* of TNT within the munitions industry, human exposure to this substance cannot be completely avoided. The goal Of a Preventive Medical Program is to prevent such exposures from causing any permanent damage to workers. Exhaust ventilation with wet Scrubbers, use of protective clothing, mandatory practice of good personal hygiene, and careful medical supervision have combined to accomplish this goal. The use of the Thymol Turbidity Test m surh a program was a valuable indicator of liver malfunction, t 11452. KRAMER, C.G. (Dow Chem. Co., Midland, Mich. 48640, USAJ and J. E,, MUTCH1.ER. The correlation of clinical and environ mental measurements for workers exposed In vinyl rMofoi". AM IND HYG ASSOCl 33(1): 19-30, lllus, 1972.--A methrd is described for the statistical consolidation and correlation of environmental measurements and clinical findings using as an example a group of hsalthy male workers exposed routinely to vinyl chloride for p-rioda up to 25 yr. Retrospective tn nature the study reveals several statis tically significant effects from chronic exposures to vinyl chloride and traces of vtnylldene chloride, t 11453. EL-DAKHAKHNY, ABDEL-ARIZ and YASSIN M. E L-5ADDC. (Dep. Occup, Health, High Inst. Public Health, Alexandria Untv., Alexandria, UAR.) Lead In hair among exposed workers. AM IND HYG ASSOC J 33(1): 31-34. lllus. lsJi.--In a study performed on 67 Pb exposed workers, a correlation was found between levels of Pb In hair and the biochemical and clinical findings. A Pb level In hair of mors than 30 pg/g could be considered as a sign oi excessive Pb level. 7 11454. LAUWERYS, R.. R. DELBROECK and H. D. VENS. (Unite Toxicol. Pathol. Travail, Catholic Univ. Louvain, Ave. ChapeUe-aux Champs 4, 1200 Brussels, Belg.) Automated analysts of delta-ammolaevullnle acid In urine. ,CLIN CHIM ACTA 40(2): 443-447. Ilhis. 1972"--The addition of an Internal standard of 5-aminolevulinic acid to the urine allows the colorimetric determination of this metabolite without the need of a preliminary chromatographic separation. The speed and accuracy make the procedure suitable for the periodic control of workers exposed to Pb. 11455. M0CSIC, J. and S. HUKOVIC. (Inst. Farmakol. Tlkstkol., Med. Fak- Sarajevo, YugoslJ Uzroci nastajanja kranicnog opstruktivnog bronhltlsa u radnlka cine metalurgije. (Causes of chrome obstruc tive bronchitis in ferrous metallurgy workers.) ARH HIG RADA TOKSDCOL 22<1): 9-32. Ulus. 197l[reed. 1972]. [Engl, summ.]--An analysis was performed on 400 people working and living under differ ent conditions of exposure to air pollution. Respiratory symptoms were questioned and the ventilation function of the Kings, O, and COJ content of arterial blood, presence of allergic phenomena, data on smoking habits and the consequences tn pulmonary and cardiovascular systems were studied. The 8 metal Ions that constituted the dust were investigated. Experiments were also performed on frogs (Rana ndibunda) J. F. L. 11456. GONCHARUK, E. I., A. A. POLYANSKII, 1.1, SHVADCO and A. A, CHDCLJ. (Dep. Public Hyg., Kiev Med. Inst- Kiev, USSR.) Fazovye izmenenlya funktstl shchltovtdnot zhelezy u krys pri khronlcheskom vozdeistvli dibromantina. (Phase alterations of thyroid function In rats exposed to the chronic activity of dibromanthin.) GIG SANIT 36(10): 108-109. lllus. 1971[recd. 1972).--The functional c(edition of the thyTold was studied in rats with 1-131 after drinking HgO with dibromanthin concentrations close to those found tn swimming pools disinfected with this chemical. In the 1st mo,, there was some excitation of thyroid function. In a 4 mo. experiment, this Utter effect was repUced at Uter periods by pronounced Inhibition. Harmful effects on humans are not certain.--N. L. G. 11457. FROLOVA, A. D. (On the methods of studying blotransformatlon of poisons in organisms ,1 PRAC LEK 24(2/3): 61-66. 1912. [Czech, and Engl. summ.|--The mechanism of the toxic effect of induetrtal poisons was discussed. The Uck of methods for Identifica tion of chemical subetancee and products of their transformation in biologic material, made these studies rather difficult. Simple methodic approach affording indirect assessment of the fate of foreign substances tn the organism had not yet lost Its importance. Hie effectiveness cf proposed simple procedures for studies of the fate of poisons was demonstrated with 3 representatives from the series of fluorated compounds.--J. A. L. 11458. nSEROVA-BEHGEROVA, VERA (Reprints; Vera FiscrovaBergerova Thomas, 145 S.E. 25th Road, Miami, FU. 33129, USA.) and J. LUDVDC CETTL. Elektrlckv model pro vstrebavani metabolismss a vytucovani benzenn u cloveka. lElectric model for the absorption metabolism and excretion of benzene in man.) PRAC LEK 24(2/3); $6-80, Ulna. 1912. [Russ, and Engl. summ.|--Die values for the resistance and capacities in the electrical analogue were dented by analogy to physiological factor* for a 70 kilo man (blood flow in nsauw 009"799