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DEPARTMENT OF HEALTH. EDUCATION. AND WELFARE*' PUBLIC HEALTH SSftVJCS
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; Occupational Health Research ; and Training Facility ; 1014 Broadway ! Cincinnati, Ohio 45202
February 15, 1967
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Dr* Lee B. Grant
Medical Director
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Pittsburgh Plate Glass Company One Gateway Center
Pittsburgh, Pennsylvania 15222
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Dear Dr. Grant:
As Dr. Cralley, mentioned in his telephone conversation with you on
February 14, 1967, we would like to include the Unibesto# Plant of
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Pittsburgh-Coming, at Tyler, Texas, in our study of occupational .
health hazards in the asbestos products industry. X would like to
summarize the main points of this study as an aid to consideration
of our request for your participation.
/j The Occupational Health Program of the National Center for Urban axd
Industrial Health, U. S. Public Health Service, has for mary years
been engaged in research into the origin ai control of occupational
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diseases. This research has most often taken the torn of epidemic* .
logic studies in which the worker's health and work environment are ' < measured over a period of time, and levels of various potential
hazards in the environment are correlated with worker health so as
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to yield an estimate of the safe level of exposure to an occupational hazard in a particular Industry.
Several years ago various industry groups requested that we conduct such a study in the asbestos products industry. The need for a study
to redefine the health problems associated with this known occupa tional hazard developed from reported observations of an association between lung cancer and asbestos. Since`our agency was known as a
technically competent impartial research organization we were asked to conduct a study*
Seme of the companies who have participated in this study to data
WV-11211
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i Dr. Lee 3. -Grant - 2/15/67 1
Ruberoid Philip Carey Certain-Teed American Brake Shoe
The design of this research project is detailed in the enclosed paper "Study or the Asbestos Products Manufacturing Industry in the United States" by levds 1. Cralley. The baseline in-plant data development involves the collecting or airborne dust and ether samples and the interviewing of all workers using the attached questionnaire- The Tyler, Texas, plant would require about four days for the air sam pling phase and about fifteen minutes per worker for the interviews. The medical studies referred to are not being considered at this tine and will only involve selected plants as arranged by further discussions.
If Pittsburgh-Coming agrees to participate in our study we would like to commence the survey of the Unibeatos plant on March 20, 1967, so as to follcw our survey of the National Gypsun plant at New Orleans.
Thank you for your interest and assistance.
Sincerely yours.
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Enclosures (2)
Jotmli
Senior Sanitary Engineer
Ihgineering Section Research and Technical
Services Branch
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< Study of the Asbei^Vroducts Manufacturing Industry^,.4 United States
X-ewia J. Cralley
Division of Occupational Health Bureau of Disease Prevention and Environmental Control
Public Health Service Department of Health, Education, and Welfare
Cincinnati,* Ohio <S*QZ
The Division of Occupational Health, Public Health Service, has underway
an extensive epidemiologic study oi the asbestos products manufacturing industry 4?
in the United States,
Purpose of Study
Hie study la designed to (a) obtain information on the health effects of exposure to the major types of asbestos used in the United States (ehrysottle,
crocidolifce, and amosite), <b) develop criteria for safe exposure levels, and
(c) establish medical and environmental criteria for surveillance where asbestos is encountered or used. Scope of Study
Baseline and longitudinal studies will be done on approximately 10,000
workers employed in the following asbestos products manufacturing areas:
(a) asbestos textile materials, (b) asbestos insulating materials, (c) asbestos
friction materials, and (d) asbettoa cement boildiag materials including asbestos
cement piping. 1
Comparative cohorts, approximately 2,$0d in each group, will be
constructed
groups oa which
isfflsa^ejivirparoectal exposure data will be obtained, along with
personnel data characterizing each individual in toe cohorts. In addition to /
I available retrospective etrrirocttental exposure data, similar prospective data
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will be added to the cohort* for the duration of the study. Pertinent medical
data will be obtained dirough baseline and follow-up examinations on a
substantial group within each cohort for clinical evaluation of the workers
during die period of the study.
Individuals la the four cohort groups, Including those who may have left
the industry, will be followed until appreciable periods of exposure, 25 years
and longer, as well as latest periods from time of first exposure have been
covered.
Through records of the Bureau of Old Age and Survivor's Insurance, death
certificates will be located on those in the cohorts oa whom benefit'Clsime have
been made. Copies of the death certificates will be obtained from the respective
state departments of health, evidence confirming causes of death will be studied,
and specific mortality rates established. These data, along with environmental
exposure, clinical and other data characterizing individuals in the cohorts, jsdU
be studied to establish.trsfeia-etd relationship*.
Baseline fo-pl^at P^ta oa Cohorts
The entire fo-plant employment of each participating plans will be included
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in constructing the four cohorts of workers. The following' information will be
obtained on each individual: (a) identifying information, including date and
place of birth, sex, places of residenceraad'*i2rsecuri cumber, <b) work
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[ore and since entering the industry, fc> fob classification and
, (d) smoking history, and tfi) hobbies. /
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Environmental data will be obtained characterizing in detail the nature and extent of in-plant exposures for each worker included in the study* Special attention will be given to assessing exposures to asbestos fibers, including different parameters of measurements such as total particulate count, fiber count, respirable mass, etc. In addition, other associated exposures such as metals, silica, specific polycyclic aromatic compounds, and radioactivity levels will be assessed.
Medical studies will be made to define the health status and trend in die cohorts throughout the study. The nature and design of these studies will evolve from the recommendations of the medical consultants to the study.
Sines the entire ia-plsat employment of the participating plants will be
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included la the study, the range of exposure levels will permit those with minimal exposure to serve as an internal control group* Controls will also be drawn from other on-going studies by the Division* Status of Study
Environments studies were started during the early part of 1963. To date baseline environmental and personnel data have been collected on over
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7,000 workers in the four groups. This phase of the study 'should be completed by the tall of 1907*
Medical studies on workers in the cohorts are anticipated to start during ' roVdtiiad7^T^bd^f rofehtgenologiats Is drawing
fading the films of asbestos workers* A contract is also underway to design the pulmonary function testa-to be used.
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Supplemental Studies Tlasbe analysis. Selective tiesues taken at autopsy are being analysed for
metala from the following categories: (a) Individuals dying from lung cancer, with and without knows exposures to asbestos; other knows exposures to metals will be sought out, (b) individuals dying from mesothelioma, with and without known exposures to asbestos; other knows exposures to metals will be sought out, (o) individuals having advanced asbestosIs, and (d) controls from the same communities. When ferruginous bodies are found in the tissues, their specific Identity will be attempted,
Socroea and Identity of fqsoirable fibers. A broad scope program Is underway to determine the sources and identity of respirable fibers of vegetable, animal and mineral nature, both of natural and synthetic origin from industrial, community and residential sources as well as hobbies and personal activities.
Records study. The mortality rates by cause, of approximately 10,000 workers employed in the asbestos textile, asbestos cement products and asbesxoe trlcnon material roanuIactuilDg'inaustryliufb^ 1958*^51 anSnave since died are being defined for comparison with expected rates.
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