Document J3NrjaaXLVq5YQ7bXgM1LkY5v
AR226-2852
PERSOWAL AND CONFIDENTIAL
Copies l:o:l
E. I. du Font de Nemours and Company
Haskell Laboratory for Toxicology and Industrial Medicine
HASKELL LABORATORY REPORT NO. 825-76
MR HO
Material Tested
Haskell No. 10,642
Sample Ready
for Testing
9-28-76
Other Codes
EYE IRRITATION TEST IN RABBITS
Procedure; One-tenth milliliter of the undiluted chemical was placed into the right cpnjunctival sac
rabbits. After 20 seconds, one treated eye was washed with tap water for one minute. The treated ey wag not washed. Observations of the cornea, iris and conjunctiva were made with a hand-slit lamp at at one, two, three and seven days; Fluor-i-strip stain and a biomicroscope were used at examinations
treatment.
Results;
Dose
0.1 ml undiluted test material
0.1 ml undiluted test material
Treatment of Eyea
Not washed
Washed
Cornea
Small area of slight opacity
1-4 hours, receding to localized microscopic surface sheen at one day.
Localized area of slight opacity at 1 hour.
Ocular Effects
Iris
Conju
None
Redness; Mild 1 ho Swelling; Slight 1
Discharge: Moderate
positlve at 1 hour,
4 hours.
None
Redness: Slight 1 Swelling; Mild 1 h
Discharge; Moderate posltive at 4 hours
CompaW ^^.D^
- .
-2-
Summary:! ^^ffffsroduced a small area of slight corneal opacity and mild conjunctivitis with no ir
rabbit eye. Corneal opacity was reversible and the eye was normal within 7 days. An; eye dosed with
promptly washed had transient minimal corneal opacity and mild conjunctivitis with no iritic effect. within 4 hours except for a persistant mild conjunctlval irritation which was normal within 7 days.
Although only temporary mild ocular effects occurred, good hygienic practice would be to fl water after any eye contact with this material.
? DFE:ms
I Report No. 825-76
| Date Issued: November 5, 1976
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-Report by;
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Doris F. Edwa Toxicologis
Approved by;
/6^r>^o.^/ vl Ravymond W-. Mo
Chief, Dermal and Ocular To
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