Document J3Gkw9eLRJ7MN3EERdzpx5jmK

DOW - TOXICOLOGY REQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 1 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OF DOSAGE 1 SPECIES |mouse Save tissues 1^ YES NUMBER OF DOS^i TIME SINCE LAST DOSE CLIHICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* zo PATHOLOGY NUMBER 76-117H CHARGE NUMBER 177-0007700 ROOM T NUMBER HET K-1711-(22; date A (0-11 CAGE ROUTE OF ADMINISTRATION DIETARY J0JNHALATION ORAL D skin METABOLISM INJECTION (IP, IM. ETC.) PHOTOGRAPHED DATE 1-10-77 MODE OF DEATH MF CLAMP DECAP G7A1 SPLEEN, LIVER, KIDNEYS AND THYMUS WERE WEIGHED. THYMUS, KIDNEYS, AND LIVER WERE SAVED FOR HISTOLOGICAL EXAMINATION. THE SPLEEN WAS USED FOR CULTURE PURPOSES. NVL 33 fio CO O co CO N> 00 PATHOLOGIST/' V VvT R. F. SHARMA DVM/i^O " *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART. LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS J DOW - TOXICOLOGY i 1^ ` '' * REQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 2 SEX MALE 1 SPECIES piOUSE pathology number 76-11715 CHARGE HUMBER 177-0007700 SAVE TISSUES ROOM 5<]yES CD NO T NUMBER HET K-1711--(22, DATE /-/o~~n CAGE Vim. CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OF DOSAGE NUMflEft OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS- (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY# ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 1-10-77 MODE OF DEATH MF CLAMP DECAP G7Aj SPLEEN, LIVER, KIDNEYS, AND THYMUS WERE WEIGHED. THYMUS, KIDNEYS, AND LIVER WERE SAVED FOR HISTOLOGICAL EXAMINATION THE SPLEEN WAS USED FOR CULTURE PURPOSES. 20 Co C/> NVL . O CO ~A CO IVJ CD f APATHOLOGIST R. P. SHARMA DVM,PhD THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA. LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY * * REQUEST FOR PATHOLOGY PATHOLOGY NUMBER 76-11716 T NUMBER % HET K-1711--(22) REQUESTED BY INHALATION STUDY Ear mark SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 0 PPM DURATION Of DOSAGE | SPECIES (MUSE Hmhtk'6? boiEi" TIME SINCE LAST DOSE CLINICAL SIGNS- (IF PRESENT) GROSS PATHOLOGY REPORT charge number 177-0007700 SAVlTTISSUES ROOM Q OH.YES n DATE /- eQ-'U ROUTE OF ADMINISTRATION DIETARY "Sjnhalation ORAL SKIN METABOLISM INJECTION (IP. IM, ETC.) PHOTOGRAPHED DATE 1-10-77 G7Aj NECROPSY* MODE OF DEATH MF CLAMP DECAP SPLEEN, LIVER, KIDNEYS, AND THYMUS WERE WEIGHED. THYMUS, KIDNEYS, AND LIVER WERE SAVED FOR HISTOLOGICAL EXAMINATION. THE SPLEEN WAS USED FOR CULTURE PURPOSES. NVL 30 & (/) tOo --i CO CO o PATHOLOQ R. P. SHARMA DVM,PhO *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, -4 STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY REQUEST FOR PATHOLOGY REQUESTED BY INHALATION- STUDY EAR MARK 4 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OF DOSAGE specie's MOUSE NUMBER OF DOSti TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* PATHOLOGY NUMBER 76-11717 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM YES CUnO HET K-1711-(22 DATE /O'77 CAGE ROUTE OF ADMINISTRATION DIETARY (S INHALATION ORAL SKIN METABOLISM INJECTION (IP. IM. ETC.) photographed DATE 1-10-77 MODE OF DEATH MF CLAMP DECAP G7Ai SPLEEN, LIVER, KIDNEYS, AND THYMUS WERE WEIGHED. THYMUS, KIDNEYS, AND LIVER WERE SAVED FOR HISTOLOGICAL EXAMINATION. THE SPLEEN WAS USED FOR CULTURE PURPOSES. NVL JO So O) Co CO CO PATHOLOGIST R. P. SHARMA DVM,PhD J*THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE- INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY REQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK sex 5 MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OP DOSAGE 1 SPECIES fTOUSE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGHS - (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* PATHOLOGY NUMBER 76-11718 CHARGE NUMBER 177-0007700 save tissues ROOM {71 YES f~l NO T NUMBER HET K-1711-(22 DATE CAGE ROUTE OF ADMINISTRATION DIETARY 0-INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 1-31-77 MODE OP DEATH MF CLAMP DECAP G16Aj KIDNEY, LIVER, SPLEEN, AND THYMUS WILL BE WEIGHED NVL JO a w o OJ go CO to PATHOLOGIST p. SriAIiMA LiVM.rt'.-J *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA. LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS 3Cil H\ DOW - TOXICOLOGY .! '-1 S- REQUEST FOR PATHOLOGY REQUESTED BY ITTHALATION STUDY EAR MARK 6 SEX MALE 1 SPECIES |molse PATHOLOGY NUMBER 76-11719 CHARGE NUMBER 177-0007700 SAVE TISSUES Hyes ROOM i M T NUMBER . HET K-1711-(22) txst1-7H-TI------------------------------------------ material VINYL CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OP DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IP PRESENT) GROSS PATHOLOGY REPORT NECROPSY* ROUTE OF ADMINISTRATION OIETARY [3JNHALATI0N ORAL SKIN METABOLISM INJECTION (IP, IM. ETC.) PHOTOGRAPHED DATE 1-31-77 MODE OP DEATH MF CLAMP DECAP G16AJ KIDNEY, LIVER, SPLEEN, AND THYMUS WILL BE WEIGHED. NVL 30 8 CO O co CO CO CO PATHOLOGIST JfcP.SHARMA DYALFhD *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED.- TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY ">; x ij*' x* X REQUEST FOR PATHOLOGY REQUESTED EY INHALATION STUDY EAR MARK 7 Tex------------------------------------------- SPECIES MALE MOOSE MATERIAL Vim. CHLORIDE DOSE CONCENTRATION 0 PEM DURATION OF DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT PATHOLOGY NUMBER 76-11720 SAVE TISSUE* STyes CHARGE NUMBER 177-0007700 ROOM Ono T NUMBER HET K-1711-(22 DATE / - 2LH -77 CAGE ROUTE OP ADMINISTRATION DIETARY 53. INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM. ETC.) PHOTOGRAPHED DATE 1-31-77 G16A NECROPSY* MODE OF DEATH MF CLAMP DECAP KIDNEY, LIVER, SPLEEN, AND THYMUS WILL BE WEIGHED. NVL 2D P* CO O co CO CO -fo PATHOLOGIST R. P. SHARMA DYM,PhD *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMAOi, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY REQUEST FOR PATHOLOGY requested by INHALATION STUDY EAR MARK 8 SEX MALE MATERIAL VINYX CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OF DOSAGE SPECIES MOUSE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS- (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* PATHOLOGY NUMBER 76-11721 charge number 177-0007700 TavITTRlTH---------- --------------- ROOM 0-YES Dno TNUMBER SET K-1711-(22> date CAGE ROUTE OF ADMINISTRATION DIETARY 0 INHALATION ORAL skin METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 1-31-77 MODE OF DEATH MF CLAMP DECAP G16Aj KIDNEY, LIVER, SPLEEN, AND THYMUS WILL BE WEIGHED. NVL 37 CO O Co -M CO CO cn PATHOLOGIST &.P.SI iYM,PhD THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACM, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY .i "5 J 7 t .'1 * *j* i JK .REQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY AR MARK 9 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OF DOSAGE 1 SPECIES pfOTJSE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS- (IF PRESENT) CROSS PATHOLOGY report PATHOLOGY NUMBER 76-11722 CHARGE NUMBER 177-0007700 SAVE TISSUES 'ROOM 0[Xyes no T NUMBER HET K-1711 -- ( 22' DATE Z--2.Z-T) CAGE ROUTE OF ADMINISTRATION DIETARY ^INHALATION ORAL SKIN METABOLISM INJECTION (IP. IM. ETC.) PHOTOGRAPHED DATE 3-1-77 G35Aj NECROPSY* SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL MODE OF DEATH MF CLAMP DECAP 33 CO o CO CO CO O) ~~~TISSUE PROCEsFnSH^nTTpfr-- Cut down EM8E0DED SECTIONED STAINED Fll Fn _initials DATE ------------ - ------------------- ~HCtr PATHOLOGIST \j JR.P. S f uVj-l v .> i(, i) *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, / STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS MICROSCOPIC EXAMINATION* 76-11722 Liver Kidney Thymus NVL NVL NVL OATS 6-6-77 Hand Jarittnn 30 Co CO o co --* CO CO -J font 0- WHO PRINTED IN UXK U-M * UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN. EMBEDDED DOW - TOXICOLOGY |REQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 10 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OF DOSAGE I SPECIE5 POUSE Save tissues SI YES numbeA of doses TIME since last dose CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* 'o:. - ! PATHOLOGY HUMBER 76-11723 CHARGE NUMBER 177-0007700 ROOM T NUMBER HET K-1711- (22) DATE 2-27.-11 CAGE ROUTE OF ADMINISTRATION DIETARY 3 INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM. ETC.) PHOTOGRAPHED DATE 3-1-77 MODE OF DEATH MF CLAMP DECAP G35Aj SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL 30 0 CO o CO CO CO 00 ~T1SU PROCESS CHECK USI ___________ " --------- ~~ 1 INITIALS '^nT'nTiwN -irM'p'F'nbEQ SEbTToFEQ -sYAiTita T(LEQ~~~~ _ --.--.-- On TA '// OATE PATHOLOGIST R. P. SHARMA DVM,PhD *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) ^WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS MICROSCOPIC EXAMINATION* 76-11723 Liver Kidney Thymus NVL NVL NVL DATE 6-6-77 Hand O) co co r-- CO O CO s CC PATHOLOGIST DATE rnttu r> MOM (mhmTfo im U.S.A. 10-M * unless otherwise noted all tissues were fixed in neutral buffered formalin, embedded u DOW - TOXICOLOGY riO f T S'* 1EQUEST FOR PATHOIOGY PATHOLOGY NUMBER 76-11724 HET -1711--(22) REQUESTED BY INHALATION STUDY EAR MARK 11 SEX MALE | SPECIES flOUSE CHARGE NUMBER 177-0007700 SAVE TISSUES r6Hm Cl NO YES DATE 2 'Zl-11 CAGE MATERIAL YINYL CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OP DOSAGE NUMBER OF Doili TIME SINCE LAST DOSE CLINICAL SIGNS- (IF PRESENT) GROSS PATHOLOGT REPORT NECROPSY* ROUTE OF ADMINISTRATION DIETARY [^INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE MODE OP DEATH 3-1-77 MF CLAMP DECAP G35AJ SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL PATHOLOGIST R^P. SHARMA DVM,Pi$ Tissue process checkUst-- "cut DOWN EMAFonpi-i .SECTIONED "filed -------------- INITIALS --------------- --' fit DATE 7'j* U 1 ^77 31 0) co CO o *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA. LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS MICROSCOPIC EXAMINATION* 76-11724 Liver Kidney Thymus Slight NVL NVL fatty infiltration 3J 5? CO o 03 J. 03 4* OATS 6-6-77 Hand Written PaThologTST FQRtt O 32030 PRINTED IN U^A. 104* 76-'>-7 * UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN, EMBEDDED DOW - TOXICOLOGY A,, EQUEST FOR PATHOLOGY Requested by INHALATION STUDY EAR MARK 12 sex MALE [species jMOUSE PATHOLOGY NUMBER 76-11725 CHARGE NUMBER 177-0007700 SAVE TISSUES TSIyes Dmo ROOM HET K-1711--(22) DATE 2. 2.Z.-11 cage - MATERIAL VINTl CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OF DOSAGE numbeT8 if toSEi TIME SINCE LAST DOSE CLINICAL SIGNS- (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* ROUTE OF ADMINISTRATION DIETARY i& INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM. ETC.)____________ PHOTOGRAPHED 3-1-77 G35AJ MODE OF DEATH MF CLAMP DECAP SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. 31 NVL W o w CO .fcp TISSUE PROCESS CHECK LIST cur DOWN EMBEDDED SECTIONED STAINED FILED INITIALS DATE X/?c/ *7 0 *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE HO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS. ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS I* Tn (FRONT) MICROSCOPIC EXAMINATION* 76-11725 Liver Kidney Thymus Slight fatty infiltration NVL NVL DATE 6-6-77 Hand Written 33 ifi o to 00 03 PATHOLOGIST FORM 0- 33030 PRINTED IN I4AA. 10-63 UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN, EMBEDDED DOW - TOXICOLOGY 4<i. REQUEST FOR PATHOLOGY ^REQUESTED BY INHALATION STUDY EAR MARK 13 SEX MALE SPECIES prousE save tissues yes PATHOLOGY NUMBER 76-11726 CHARGE NUMBER 177-0007700 ROOM T NUMBER HET K-1711-(22) .1-1-11 CAGE O MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OF DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT N* c> c. ro Tls.^k eAo-m . -fir s.m. n^H ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE MODE OF DEATH 3D gj O ^ CO -ts. ^ 3 -1-1 1 PATHOLOGIST the following tissues were examined and unless noted above no visible lesions (NVU WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS ~v DOW - TOXICOlOor . *5 i * ^tE<EQUEST FOR PATHOLOGY ^ REQU TtfffliLATION STUDY Ear mark 14 SEX MALE SPECIES MOUSE PATHOLOGY NUMBER ' 76-11727 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM Dyes Dno -5 : i M HET K-l711-(22) DATE 3-1-77 CAGE Eftm CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OF DOSAGE NUMBER OP DOSES TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) N6CR0PSY+ GROSS PATHOLOGY REPORT fO O OfOij . (J ^ Tusi^c&t/y)- TB^\ ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE MODE OF DEATH 3-/' 77 33 0) o co ppbA CO 4* cn PATHOLOGIST the following tissues were examined and unless noted above no visible lesions (NVL) WERE OBSERVED: TRACHEA. LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS - - rai DOW - TOXICOLOGY T& ,J- KEQUEST FOR PATHOLOGY REQUESTED BY HTHAiATIOH STUDY EAR MARK 15 SEX MALE I SPECIES {MOUSE MATERIAL TIUYI. CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OF DOSAGE NUMBER OF POSES TIME SINCE LAST DOSE CLINICAL SIGNS- (IF PRESEN-0 GROSS PATHOLOGY REPORT SAVE TISSUES yes PATHOLOGY NUMBER 76-11728 CHARGE NUMBER 177-0007700 ROOM HET K-1711 -- (22' 3-1-11 CAGE ...................... OZ ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE NECROPSY* (\J o 0.1-0 5 3 f) liJi , MODE OF DEATH T3el| 3-1-11 PATHOLOGIST oa Qo to o co --A CO -b o> the following tissues were examined and unless noted above no visible LESIONS CNVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY Os r .A m.EQUEST FOR PATHOLOGY PATHOLOGY NUMBER 76-11729 T NUMBER- HET K-1711-(22) requested by INHALATION STUDY EAR MARK 16 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OF DQSAOE "speeds MOUSE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT CHARGE NUMBER 177-0007700 save tissues "r"6om yes Oho date 3-t-ll CAGE ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED MODE OF DEATH JO w o CO --A 00 (A -4 NECROPSY# ^ AO^ro Ji C-*<<X,rvN - TSe// 3-1-11 PATHOLOGIST *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED; TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS j DOW - TOXICOLOGY ^lEQUEST FOR PATHOLOGY PATHOLOGY NUMBER 76-11730 EET K-1711-(22) REQUESTED BY IHHALATIOff STUDY EAR MARK 17 SEX MALE SPECIES MOUSE CHARGE NUMBER 177-0007700 SAV TISSUES ROOM Oyes S3 NO 1-21-1I CAGE MATERIAL Vim. CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OF DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSl CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY (ST INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE NECROPSY* no 0. ros5 <2kcx t'v-s -- ^ p\covA C_LJ \ L> MODE OF DEATH 33 fio CO O CO CO -b 00 PATHOLOGIST the following tissues were examined and unless noted above no visible lesions (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS J i DOW - TOXICOLOGY M O i T A VI i M < REQUEST FOR PATHOLOGY PATHOLOGY NUMBER 76-11731 Requested by HTHALATIOIT STUDY EAR MARK 18 SEX MALE 1 SPECIE* pIOUSE CHARGE NUMBER 177-0007700 SAVE TISSUES yes Sno r5om inwmoin .t HET K-1711--(22) 1-3I-T7 MATERIAL VINYL CHLORIDE DQS CONCENTRATION 0 PPM DURATION OF DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS- (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY & INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE NECROPSY* Oo cxro5S O c-<c^yvx - MODE OF DEATH PATHOLOGIST F0RU C*33030 PRINTED R-13-73 37 Co CO o CO --A CO (O the following tissues were examined and unless noted above no visible lesions (NVL) WERE OBSERVED: TRACHEA. LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, y STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS (FRONT1 DOW - TOXICOLOGY REQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY ar mark sex 19 MALE species MOUSE PATHOLOGY NUMBER 76-11732 SAVE TISSUES CHARGE NUMBER 177-0007700 r61Sm yes I3.N0 T NUMBER EET K-1711--(22) 1-31-Y? CAGE VINYL CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OF DOSAGE NUMBER OF OOSES TIME SINCE LAST DOSE ROUTE OF ADMINISTRATION DIETARY [3 INHALATION ORAL , CLINICAL SIGNS- (IF PRESENT) SKIN METABOLISM INJECTION (IP, IM, ETC.) GROSS PATHOLOGY REPORT PHOTOGRAPHED DATE f\o cxros5 w\ -- 5^\ee-A C AKa ik hMODE OF DEATH NECROPSY* W J ^ CO cn O PATHOLOGIST the following tissues were examined and unless noted above NO visible LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY *4 * EQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK SEX 20 MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OF DOSAGE SPECIES MOUSE NUMBER OP t)OSa TIME SINCE LAST DOSE CLINICAL SIGNS- (IF PRESENT) GROSS PATHOLOGY REPORT PATHOLOGY NUMBER 76-11733 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM yes Sno HET K-1711-(22' DATE I-3I-TI CAGE ROUTE OF ADMINISTRATION DIETARY |3 INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE NECROPSY* o o,rosrA s e_pco~Yv'N \J cuj\Vorc- mode of death C< w o w CO Ul PATHOLOGIST the following tissues were examined and unless noted above no visible LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY REQUEST FOR PATHOLOGY REQUESTED BT INHALATION STUDY EAR MARK 21 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OF DOSAGE SPECIES MOUSE NUMBER OF DOSES time since last dose CLINICAL SIGNS - (IF PRESENT) CROSS PATHOLOGY REPORT NECROPSY* PATHOLOGY NUMBER 76-11734 CHARGE NUMBER 177-0007700 SAVE TISSUES ~*fyQ-YES 1 1 NO ROOM T NUMBER HET K-1711--(22' ATE CAGE ROUTE OF ADMINISTRATION DIETARY gl. INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM. ETC.) PHOTOGRAPHED DATE MODE OF DEATH 3-1-77 MF CLAMP DECAP G35A1 SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL 00 Bo 0} o CO -A CO 01 to PATHOLOGIST / J?. P. SHARMA DVM,PbO TISSUE PROCESS CHECK LIST cur down Em BEDDfcD SECTIONED STA INED FILEID INITIALS DATE /} 1 --Ft~ -Oz'r"c? J7^-QfS ^77 *THE following tissues were examined and ESS unl NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AN D REPRODUCTIVE ORGANS / MICROSCOPIC EXAMINATION* 76-11734 Liver Kidney Thymus NVL NVL NVL oat<d-6-77 ~Bsm-- Written JO So w o CO CO cn co PATHOLOGIST DATE 6 7-'o'7 rORM o-0M PRINTED IN ilia. U-M * UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN, EMBEDDED DOW - TOXICOLOGY 1EQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 22 SEX MALE SPECIES MOUSE pathology number 76-11735 CHARGE HUMBER 177-0007700 SAVE TISSUES ROOM f^YES 1 1 NO T NUMBER HET K-1711--(22) 2. '2.L.-T? CAGE MATERIAL, VINYL CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OF DOSAGE number 6f~6oses TIME SINCE LAST DOSE CLINICAL SIGNS - {IF PRESENT} GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY 0 INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED 9-l-77 G35Aj NECROPSY* SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL MODE OF DEATH MF CLAMP DECAP 33 w o co --A CO CJ1 PATHOLOGIST R. P. SHARA^A DVM,Ph J TISSUE PROCESS CHECK 1 1ST ' CUT DOWN EMBEDDED SECTIONED STAINED FILED initials DATE /T) / ----- Ktr *70 T-C <^ t --77 THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS MICROSCOPIC EXAMINATION* 76-11735 Liver Kidney Thymus NVL NVL NVL StTM < R&S 031355 PATHOLOGIST +--< DATE FORM c MWO PKWTeo IN OAA. 10-W # UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN. EMBEDDED l/ DOW - TOXICOtOOr EQUEST FOR PATHOLOGY REQUESTED BY UTHAiATION STUDY BAR MARK 23 SEX MADE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OP DOSAGE SPECIES MOUSE HUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* PATHOLOGY NUMBER 76-11736 say4 Tissues CHARGE NUMBER 177-0007700 ROOM CStfES Dno HET K-1711-(22' Z.'ZZ -'H CAGE ROUTE OF ADMINISTRATION DIETARY Inhalation ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 3-1-77 MODE OF DEATH MF CLAMP DECAJP G35Aj SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL 20 CO o co -A CO Cl O) PATHOLOGIST R. P. SHARMA DVM^W * THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) 'WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, y STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS MICROSCOPIC EXAMINATION* 76-11736 Liver Kidney Thymus NVL NVL NVL DATE, ,, _ 6-6-77 Hand Written R&S o w CO CJ1 "4 FOAM C- 32030 PRINTED IN U.LA, 1M * UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN. EMBEDDED DOW - TOXICOLOGY 1 ' .-A 0 EQUEST FOR PATHOLOGY ORPEQUESTED BY BTHALATION STUDY EAR MARK 24 SEX MALE 1 SPECIES pOUSE pathology number 76-11737 CHARGE NUMBER 177-0007700 SAVE TISSUES SAyes (Z|no ROOM . i\* T HUMBER HET K-1711-(22) Z-ZL-ll ca5Z------------------------------------------ material YITTYIi CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OF DOSAGE NuBSBRWBS'iB" TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY H INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 3-1-77 G35AJ NECROPSY* MODE OF DEATH MF CLAMP DECAP SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED NVL 37 fio to o co --A CO cn oo PATHOLOGIST R, P, SHARiLMV,A UuVM,.Phh:D THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, j STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS MICROSCOPIC EXAMINATION* 76-11737 Liver Kidney Thymus Perinuclear .inftitration and degeneration. NVL NVL 6-6-77 Hand -Written &S 031359 PATHOLOGIST DATE 6''Io'"77 FORM 0- 32030 PRINTED IN UAA. 1041 * unless otherwise noted all tissues were fixed in neutral buffered formalin, embedded v DOW - TOXICOLOGY REQUEST FOR PATHOLOGY ^REQUESTED BY INHALATION STUDY EAR MARK 73 SEX MALE SPECIES MOUSE PATHOLOGY NUMBER 76-11738 SAVE TISSUES EH yes CHARGE NUMBER 177-0007700 1 ROOM cn no i T NUMBER HET K-1711-(22) PATE 3-1-11 cage TITO, CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE NUMBER OP DOSES time since last dose CLINICAL SIGNS (IF PRESENT) NECROPSY* GROSS PATHOLOGY REPORT pJo <\c&sS (\ I i^uc c*:c^,yv\. -Pby- ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE MODE OF DEATH . TTte/V 3-/~77 PATHOLOGIST 3J Bo 07 o co _A CO O) o* *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS / 'CftPSUTl DOW - TOXICOLOGY 4 o i 7 A r* : EQUEST FOR PATHOLOGY ^^R^REEQUESTED BY INHALATION STUDY EAR MARK 74 SEX MALE MATERIAL Vim, CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE 1 SPECIES jMOTJSE ` HUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL (IF PRESENT) GROSS PATHOLOGY REPORT PATHOLOGY NUMBER 76-11739 CHARGE HUMBER 177-0007700 SAVE TISSUES ROOM n nyes no HET E-1711--(22) DATE 3-1-11 CAGE ................. ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN |_| METABOLISM INJECTION {IP* IM( ETCJ PHOTOGRAPHED DATE NECROPSY* f\JO o, ro 33 e-<c^Y^ , _____ -M-& / Vjjue p to r :e. rr] MODE OF DEATH TBUI 3-i-11 73 CO o CO CO 05 PATHOLOGIST the following tissues were examined and unless noted above no VISIBLE LESIONS (NVU WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE,. AND REPRODUCTIVE ORGANS fCO^AITt DOW - TOXICOLOGY REQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 75 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE SPECIES MOUSE NUMBR OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS- (IF PRESENT) GROSS PATHOLOGY REPORT PATHOLOGY NUMBER 76-11740 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM (ZIyES CD NO HET K-1711-(22 DATE 3-I-T7 CAGE ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED NECROPSY* Mo ^r5S eKo.)r>-v . MODE OF DEATH 7"7jJure '/or TB^ii -3 1-77 PATHOLOGIST 33 0 W O CO CO CT) IO *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS /cn/MiTi DOW - TOXICOLOGY A EQUEST FOR PATHOLOGY ^REQUESTED BY INHALATION STUDY EAR MARK SEX SPECIES 76 MALE MOUSE PATHOLOGY HUMBER 76-1174-1 CHARGE NUMBER 177-0007700 SAVE TISSUES yes Qno ROOM HET K-1711-(22) ""M'77 CAGE *1 MATERIAL VINTYL CHLORIDE OOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE NUMBISf OfHxDSEi TIME SINCE LAST OOSE CLINICAL SIGNS - (IF PRESENT) )e3d).ryy coy GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SK|N METABOLISM INJECTION (IP. IM. ETC.)_________ PHOTOGRAPHED 37 W o CO CO O) CO Mo yc&sNECROPSY* :7(QivvnCu:Ola MODE OF DEATH <3v^r ca.\p o PATHOLOGIST *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY m EQUEST FOR PATHOLOGY requested by INHALATION STUDY EAR MARX 77 SEX MALE SPECIES MOUSE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE NUMBER 6p DOSES TIME SINCE LAST DOSE CLINICAL SIGNS. (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* PATHOLOGY NUMBER 76-11742 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM 0.YES CH NO i nvwgcB HET K-1711-(22) CAkGGE ROUTE OF ADMINISTRATION DIETARY ^ INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED date MODE OF DEATH 1-10-77 MF CLAMP DECAF G7A1 SPLEEN, LIVER, KIDNEYS, AND THYMUS WERE WEIGHED. THYMUS, KIDNEYS, AND LIVER WERE SAVED FOR HISTOLOGICAL EXAMINATION. THE SPLEEN WAS USED FOR CULTURE PURPOSES. Externally The back of the animal had inflamed areas and some hard WMaalaa. These will be saved for histological examination. NVL 30 e (/) o 00 _A CO O) -u PATHOLOGIST R. P. SHARMA DVM.PhD THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS J DOW - TOXICOLOGY 1EQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 78 SEX MADE "" 1 SPECIES [MOUSE PATHOLOGY NUMBER 76-11743 CHARGE NUMBER 177-0007700 SAVE TISSUES Syes n no ROOM HET K-1711-(22) (- fO '11 CAGE MATERIAL Yim. CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* ROUTE OF ADMINISTRATION DIETARY ^INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 1-10-77 MODE OF DEATH MF CLAMP DECAP G7Aj SPLEEN, LIVER, KIDNEYS, AND THYMUS WERE WEIGHED. THYMUS, KIDNEYS, AND LIVER WERE SAVED FOR HISTOLOGICAL EXAMINATION. THE SPLEEN WAS USED FOR CULTURE PURPOSES. Externally Int lly The hack of the animal and the tail was physically damaged and had some scabs. All organs - NVL. X fio w o CO -A coCn>O PATHOLOGIST R. P. SHARMA DVMfPhD THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE. LARGE INTESTINE, AND REPRODUCTIVE ORGANS J DOW - TOXICOLOGY .REQUEST FOR PATHOLOGY ^REQUESTED BY INHALATION STUDY EAR MARK 79 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 1000 PPM duration of dosage SPECIES MOUSE NUMBER OF DOSES time since last dose CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* PATHOLOGY NUMBER 76-11744 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM Hyes Dno HET K-1711-(22, DATE 1- ,0 -17 cagI ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 1-10-77 MODE OF DEATH MF CLAMP DECAP G7AJ SPLEEN, LIVER, KIDNEYS, AND THYMUS WERE WEIGHED. THYMUS, KIDNEYS, AND LIVER WERE SAVED FOR HISTOLOGICAL EXAMINATION. THE SPLEEN WAS USED FOR CULTURE PURPOSES. Externally In*-'mally The abdomen of the animal had hardened muoelac about h cm in size with inflammation on this. Inside it appeared like a hematoma and this has been saved for histological examination. NVL V) O 00 -A CO cn o> PATHOLOGIST R. P. SI [ARMA DVM,PhD *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED; TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS J DOW - TOXICOLOGY tEQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 80 SEX MALE SPECIES MOUSE PATHOLOGY NUMBER 76-11745 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM S/YES HU NO T NUMBER HET K-1711-(22) date /- to-'7~7 CAGE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 1000 PPM duration of dosage NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS- (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY ^.INHALATION ORAL skin METABOLISM INJECTION (IP, IM, ETC.) photographed DATE 1-10-77 G7Aj NECROPSY* MODE OF DEATH MF CLAMP DECAP SPLEEN, LIVER, KIDNEYS, AND THYMUS WERE WEIGHED. THYMUS, KIDNEYS, AND LIVER WERE SAVED FOR HISTOLOGICAL EXAMINATION. THE SPLEEN WAS USED FOR CULTURE PURPOSES. NVL J3 (/) O CO -A CO o> R. P. SHARMA DVM,PhD THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED; TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY 1EQUEST FOR PATHOLOGY REQUESTED BY BTHALATIOH STUDY Ear mark 81 SEX MAiE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 1000 PPH DURATION OF DOSAGE 1 SP^tlES (mouse NUMBER QF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS- (IF PRESENT^ GROSS PATHOLOGY REPORT PATHOLOGY NUMBER 76-11746 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM RTyes CH NO HET K-1711--(22) /'2Y-77 CAGE ROUTE OF ADMINISTRATION DIETARY gf INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 1-31-77 G16Aj NECROPSY* MODE OF DEATH MF CLAMP DECAP KIDNEY, LIVER, SPLEEN, AND THYMUS WILL BE WEIGHED. NVL DO fi (0 o CO CO O 00 PATHOLOGIST R. P. SHARMA DVM,PhD THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY m EQUEST FOR PATHOLOGY REQUESTED BY INHALATIOIT STUDY Ear mark 82 SEX MALE SPECIES MOUSE PATHOLOGY NUMBER 76-11747 CHARGE NUMBER 177-0007700 SAVE TISSUES I^YES f~l NO ROOM I nuwDCK HET K-1711-(22) '/-2.Y-77 CAGE MATERIAL YIUYL CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) photographed DATE 1-31-77 MODE OF DEATH MF CLAMP DECAP G16Aj KIDNEY, LIVER, SPLEEN, AND THYMUS WILL BE WEIGHED. NVL 30 C to o co -A CO o> (O PATHOLOGIST ( R. P. SHAI DVM,PhD THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED; TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY A T ' EQUEST FOR PATHOLOGY PATHOLOGY NUMBER 76-11748 K-1711-(22) REQUESTED BY DTHALATIOIT STUDY EAR MARK 83 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE 1 SPECIES pIOUSE NUMBER of doses TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT CHARGE NUMBER 177-0007700 SAVE TISSUES Myes CD NO I ROOM 1 t-ZX'll caSI------------------------------------------ ROUTE OF ADMINISTRATION DIETARY ^INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 1-31-77 G16AJ NECROPSY* mode df death MF CLAMP DECAP KIDNEY, LIVER, SPLEEN, AND THYMUS WILL BE WEIGHED. Externally Internally NVL Lungs - slightly congested. A piece has been saved for histological examination. 30 CO PATHOLOGIST &.P. SHARMA DVM,PhD THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA. LUNG, HEART, LIVER, KIDNEYS, ADRENAL. SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE,. AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY REQUEST FOR PATHOLOGY PATHOLOGY NUMBED 76-11749 nwma 5 HET K-1711-(22' requested by INHALATION STUDY EAR MARK 84 SEX MALE MATERIAL Vim. CHLORIDE 00$E CONCENTRATION 1000 PPM DURATION OF 00SA0E SPECIES MOUSE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) CROSS PATHOLOGY REPORT CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM nX YES NO DATE /-2V-77 CAGE ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP. IM. ETC.)_____________ photographed DATE 1-31-77 G16AJ NECROPSY* MODE OF DEATH MF CLAMP DECAP U KIDNEY, LIVER, SPLEEN, AND THYMUS WILL BE WEIGHED. 05 NVL O Co --A Co N PATHOLOGIST R. P. SHARMA DVM.PHD *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY KEQUEST FOR PATHOLOGY PATHOLOGY NUMBER 76-11750 T NUMBER HET K-1711--(22) REQUESTED BY HTHA.LATIOH STUDY EAR MARK 85 SEX MADE SPECIES MOUSE CHARGE NUMBER 177-0007700 SAVE TISSUES 1^0 YES ROOM date 2.Cage MATERIAL VINYI CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* ROUTE OF ADMINISTRATION DIETARY ^.INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 3-1-77 G35AJ MODE OF DEATH MF CLAMP DECAP SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL 37 Ho CO O co --A CO to TISSUE PROCESS CHECK LIST CUT DOWN embeods d SECTIONED STAINED FILED initials DATE --------- r? i Kt -- PATHOLOGIST --4L JL P. SHARMA DVMfPfaD *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS / MICROSCOPIC EXAMINATION* 76-11750 Liver Kidney Thymus Mild NVL NVL swelling ofhepatocytes "Hand-- Written J3 </) o oo 00 ~sl 00 PATHOLOGIST FOIW 0- MOM PNtNTED IN U.LA. NHW DATE 6 7^ - /o-v lie UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN, EMBEDDED DOW - TOXICOLOGY ; ' ;:/ r EQUEST FOR PATHOLOGY F*eouesTgD by INHALATION STUDY EAR MARK 86 SEX MALE SPECIES flOUSE pathology number 76-11751 CHARGE NUMBER 177-0007700 SAVE TISSUES f^fES NO ROOM t nW^BCR HET K-1711-(22) DATE cagI MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS- (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* ROUTE OF ADMINISTRATION DIETARY ^-INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 3-1-77 MODE OF DEATH ME CLAMP DECAP G35A1 SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL PATHOLOGIST R. P. SHARMA DVM,PW> TISSUE PROCESS CHECK LIST cu r Down embeodf d SECTIONED STAINED FILED INITIALS /Sc) . J DATf- -- rz~ 33 fio CO o co --A CO -J THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS /RDftklT\ MICROSCOPIC EXAMINATION* 76-11751 Liver Kidney Thymus Slight dilation of sinusoids NVL NVL 33 CO o to -A to --4 Ul DATE 6 -6-77 Hand Written PATHOLOGIST DATE b-'i*-7 ~J FORM c-WHO printed in UAA. 1*M * UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN, EMBEDDED to kr*v' 1/ DOW - TOXICOLOGY REQUEST FOR PATHOLOGY PATHOLOGY NUMBER 76-11752 inumDCK HET K-1711-(22) REQUESTED BY INHALATION STUDY EAR MARK 87 SEX MA.IE SPECIES MOUSE CHARGE NUMBER 177-0007700 SAVE TISSUES 'FyHyES fl NO ROOM D'AATI EC A Z.-2JL-1I CAGE ERIAL ____ VINYL CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OR DOSAGE NUMBER of doses TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* ROUTE OF ADMINISTRATION DIETARY ^INHALATION U ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 3-1-77 MODE OF DEATH- MF CLAMP DECAP G35A1 SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. Internally Lungs - congested and one lobe has been saved for pathological examination. There were no other lesions. DO co o CO CO -vl O) PATHOLOGIST R. p. SHa,<a\a PftOM (--13030 PtMMTFO R *13*73 TISSUE PROCESS CHECK LIST cur down EMBEDDED SECTIONED STAINED FILED INITIALS DATE ~r n -2 ty\ JTHE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED; TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS (FRONTI MICROSCOPIC EXAMINATION* 76-11752 Liver Kidney Thymus NVL NVL NVL 33 (/) o to _L CO -4 BATE 6-6-77 Hand Written PATHOLOCIST DATE 6-U-77 r0W4 0-3aaPWNTEDiNUAA.l<W * UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN, EMBEDDED DOW * TOXICOLOGY t -* EQUE5T FOR PATHOLOGY REOUESTEO BY INHALATION STUDY EAR MARK 88 SEX MALE i SPECIES (MOUSE pathology number 76-11753 CHARGE HUMBER 177-0007700 SAVE TISSUES glYES no ROOM T NUMBER . HET K-1711-(22, 7-'LL-m CAGE MATERIAL ____.. VINYL CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS- (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* ROUTE OF ADMINISTRATION DIETARY ^INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 3-1-77 G35Aj MODE OF DEATH MF CLAMP DECAP SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL 37 W o co CO ~sl CO TISSUE PROCESS CHECK LIST INITIALS DATE CUT DOWN EMBEDDF D SECTIONED STAINED FILED fit r\C "77T7y V. PATHOLOGIST R. P. SHARAAA DVM,PhO *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS MICROSCOPIC EXAMINATION* 76-11753 LiverKidney Thymus -Ti NVL NVL NVL DATE 6-6-77 Hand U-r-t ft-on 3) 9 0) o 09 -A 09 -4 (0 PATHOLOGIST DATE TOIW 0- 320S0 PKtNTEO IN U.LA. W-H * UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN, EMBEDOED IM PABAFPIM AMO STAINFO HIT (BACK) 1/ DOW - TOXICOLOGY m.EQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 89 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE SPECIES MOUSE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL (IF PRESENT) NECROPSY* GROSS PATHOLOGY REPORT no across PATHOLOGY HUMBER 76-11754 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM yes Hno HETK-1711-(22 i-3i-~n CAGE ROUTE OF ADMINISTRATION DIETARY S INHALATION ORAL SKIN LJ METABOLISM INJECTION (IP* IM, ETC.) PHOTOGRAPHED DATE MODE OF DEATH q_oVV\jc^_ PATHOLOGIST 00 &> CO o co --* CO 09 O the following tissues WERE examined and unless noted above no VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY tEQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 90 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE SPECIES MOUSE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS- (IF PRESENT) GROSS PATHOLOGY REPORT PATHOLOGY NUMBER 76-11755 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM yES 0NO T NUMBER HET K-1711-(22) i -3i-~n CAGE ROUTE OF ADMINISTRATION DIETARY 0 INHALATION ORAL SKIN METABOLISM INJECTION (IP. IM, ETC.) PHOTOGRAPHED DATE NECROPSY* r\ o <A C 5 -S P/'CO'YVY ) MODE OF DEATH PATHOLOGIST 30 co o CO pA Ca) 00 the following tissues were examined and unless noted above no visible LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE. LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY EQUEST FOR PATHOLOGY equested by INHALATIOK STUDY EAR MARK 91 SEX MADE MATERIAL VHTYI CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE species MOUSE NUMBER OP DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT} NECROPSY* GROSS PATHOLOGY REPORT y*\ o aco^s i) PATHOLOGY NUMBER 76-11756 SAVE TISSUES r~I VE5 CHARGE NUMBER 177-0007700 ROOM EU T NUMBER SET K-1711-(22) CAGE ROUTE OF ADMINISTRATION DIETARY (ZkINHALATION ORAL SKIN _ METABOLISM Q INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE ----------------------------------------------------------------MODE OF DEATH 3J R* (!) O ^ CO 00 ----- PATHOLOGIST IBIM^CH D I1* T1 *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, 1 STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS (FRONTS DOW - TOXICOLOGY ;^ REQUEST FOR PATHOLOGY requested by INHALATION STUDY EAR MARK 92 SEX MALE material VINYL CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE 1 SPECIES piOUSE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS- (IF PRESENT} CROSS PATHOLOGY REPORT pathology number 76-11757 CHARGE NUMBER 177-0007700 SAVE TISSUES yes R[no ROOM T NUMBER HET K-1711-(22) DATE V~3\'T1 CAGE ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE NECROPSY* f\0 exros5 iJ ~ 5^e.e/\ MODE OF DEATH 3D CD O CO CO 00 CO PATHOLOGIST the following tissues were examined and unless noted above no visible LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, y STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS /ContiT\ DOW - TOXICOLOGY ' : -M EQUEST FOR PATHOLOGY "requested by INHALATION STUDY EAR MARK 93 SEX MALE SPECIES MOUSE pathology number 76-11758 SAVE TISSUES CHARGE NUMBER 177-0007700 ROOM $yes CDno T HUMBER HET K-1711- ( 22' DATE CAGE Zt material VINYL CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE NUMBER of doses time SINCE LAST DOSE CLINICAL (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY qOnhalation ORAL SKIN LJ METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHEO DATE 3-1-77 ) G35Aj NECROPSY* mode of death MF CLAMP DECAP SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL tissue" process check list* CUT GOWN EMBEDDED SECTIONED STAINED FILED INITIALS DATfc W7~ JOJ2 TVS ^>y PATHOLOGIST R. p. SHARMA DWh the following tissues were examined and unless noted above NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, v STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS MICROSCOPIC EXAMINATION* 76-11758 Liver Kidney Thymus NVL NVL NVL DO CO o 03 03 00 CJ1 OATI 6 FORM O 32030 PRIRTC0 (N UJLA. M-M * UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN, EMBEDDED DOW - TOXICOLOGY t EQUEST FOR PATHOLOGY ^REQUESTED BY INHALATION STUDY EAR MARK 94 SEX MALE SPECIES MOUSE PATHOLOGY NUMBER 76-11759 CHARGE NUMBER 177-0007700 SAVE TISSUES 1^3 YES DnO ROOM T NUMBER HET K-1711-(22' DATE 2-'2.2 -11 CAGE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE 'RuiueirfiFisasej TIME SINCE LAST DOSE CLINICAL SIGNS- (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* ROUTE OF ADMINISTRATION DIETARY ^INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM. ETC.) PHOTOGRAPHED DATE 3-1-77 MODE OF DEATH MF CLAMP DECAP G35AJ SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED, NVL 33 CO O CO --A CO 00 O) TISSUE PROCESS CHECK LIST CUT DOWN EMBEDDED SECTIONED STAINED FILED INITIALS DATE // 07 rzs- ^22... PATHOLOGIST R. P. 5HARMA dv/yi,*'h-/ PDOU PPlMTCf, THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS MICROSCOPIC EXAMINATION* 76-11759 Liver Kidney Thymus Swelling and degenerative changes. NVL NVL U in o CO w 00 -4 6-77 Hand 4fcifetn PATHOLOGIST FORM C- MOW PRINTED IN U.LA. 10-M _S3l DATE 4wo-77 * UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN, EMBEDDED U DOW - TOXICOLOGY REQUEST FOR PATHOLOGY Feol/ested by HTHA.LATIOTT STUDY EAR MARK 95 SEX MALE material VITO CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OP DOSAGE SPECIES MOUSE. Huuadk if boiti TIME SINCE LAST DOSE CLINICAL SIGNS- (IF PRESENT) CROSS PATHOLOGY REPORT NECROPSY* PATHOLOGY NUMBER 76-11760 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM 171 YES 1 1 NO T NUMBER HET K-1711-(22) DATE Z.'ZZ -11 CAGE ROUTE OF ADMINISTRATION DIETARY ^Jj^INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 3-1-77 MODE OP DEATH MF CLAMP DECAP G35AJ SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL 20 to o w -A CO 00 03 PATHOLOGIST K. K 5HARMA DVM/hD FORM C*32030 PRINTED ft.12<73 'ISSUE PROCESS CHFOK T 1ST CUT DOWN EMBEODt-D SECTIONED STAINED FILED INITIALS caTe ------------ - '---------- V, - -------- Ktr-- THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS / (FRONT) MICROSCOPIC EXAMINATION* 76-11760 Liver Kidney Thymus Slight fatty infiltration. Congestion NVL 30 (/> o CO to CO (D DATE 6-6-77 Hand --written PATHOLOGIST DATE FORM 0- VOSS PRINTED IN UJJL * UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN, EMBEDDED 77 1/ DOW - TOXICOLOGY -* O';Ta-y* a. u REQUEST FOR PATHOLOGY *EQUESTED BY hthalatioh study EAR MARK 96 SEX MALE species MOUSE PATHOLOGY NUMBER- 76-11761 SAVE TISSUES ffivES CHARGE NUMBER 177-0007700 ROOM DnO HET K-1711-(22) Z.'T.Z'-ll CAGE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE NUMBER OF 00SET TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY Inhalation oral SKIN METABOLISM INJECTION (IP, IM. ETC.) PHOTOGRAPHED DATE 3-1-77 G35AJ NECROPSY* SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL MODE OF DEATH MF CLAMP DECAP 33 W o GJ -A CO to o PATHOLOGIST JL P. SHARMA DVM,PhD FORM C3S010 PRINTED R.12.73 T|SSUE PROClsTnHmrTTcr- CUT DOWN EmbeddfD SECTIONED I SIAINED 1 filed "initials date - --------- --------- ----------- ------------------ *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, / STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS (FRONT) MICROSCOPIC EXAMINATION* 76-11761 Liver Kidney Thymus Enclosed pancreatic tissue. NVL NVL DATE 6-6-77 Hand -Written PATHOLOGIST DATg FORM O MMO PRINTED IN U.&A. 10-M * UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN, EMBEDDED 77 DOW - TOXICOLOGY REQUEST FOR PATHOLOGY PATHOLOGY NUMBER 76-11785 T NUMBER HET K-1711-(22) REQUESTED &Y HTHALATION STUDY EAR MARK 72 SEX MALE MATERIAL Vim CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE species MOUSE NUMBER OP DOSES TIME SINCE LAST DOSE CLINICAL SIGHS (IF PRESENT) GROSS PATHOLOGY REPORT CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM SVES Dmo 'L'tt -~l~l CAGE ROUTE OF ADMINISTRATION DIETARY 13 INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 3-1-77 G35Aj NECROPSY* MODE OF DEATH MF CLAMP DECAP SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL 33 99 V) o co _l CO CD ro PATHOLOGIST R. P. L THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY [EQUEST FOR PATHOLOGY REQUESTED BY ETHALATION STUDY EAR MARK 71 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE 1 SPECIES pOUSE numser^oses TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* PATHOLOGYHUMBER 76-11784 Charge number 177-0007700 SAVE TISSUES S YES CD NO ROOM HET K-1711-(22) Z--2.1-11 CAGE ROUTE OF ADMINISTRATION DIETARY ^INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.)______________ PHOTOGRAPHED DATE 3-1-77 G35Aj MODE OF DEATH MF CLAMP DECAP SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL PATHOLOGIST R P co\w r Vi if- 00 fio 0) O 00 CO to CO THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY EQUEST FOR PATHOLOGY PATHOLOGY NUMBER 76-11783 HET K-1711--(22) REQUESTED BY INHALATION STUDY Ear mark 70 SEX MA.LE 1 SPECIES (mouse CHARGE NUMBER 177-0007700 SAVE TISSUES E<Iyes ROOM Ti-n-n CAGE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE NUMBEROF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY ^INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 3-1-77 G35Aj NECROPSY* SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL MODE OF DEATH MF CLAMP DECAP JJ Co (f) o CO _A CO CO 44 PATHOLOGIST R. P. 0l. v7v\,;7i THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, / STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY m.EQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 69 SEX MADE MATERIAL VINYI CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE SPECIES MOUSE NUMBER 0^~o$? TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* PATHOLOGY NUMBER 76-11782 charge number 177-0007700 SAVE TISSUES 'KJyes Dno ROOM I c ts HET K-1711-(22) daAtle ^ CAGE ROUTE OF ADMINISTRATION DIETARY ^INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE MODE OF DEATH 3-1-77 ________M7 CLAMP DECAP G35Aj SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL 31 0 (0 o CO --E CO (0 Or PATHOLOGIST JL P. --./WaA 0V,'A,Pii:J THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED; TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS J DOW - TOXICOLOGY [EQUEST FOR PATHOLOGY PATHOLOGY NUMBER 76-11781 HET K-1711-(22) REQUESTED BY INHALATION STUDY EAR MARK 68 SEX MA.LE i SPECIES jvrousE CHARGE NUMBER 177-0007700 SAVE TISSUES yes ^ NO ROOM i CAGE MATERIAL, VINYL CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY inhalation ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE NECROPSY* no CA- Y^ ttx: A VVv rt_ MOOE OF DEATH PATHOLOGIST 30 fio CO o Go --K GO CO CD * THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS J DOW - TOXICOLOGY 1EQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 67 SEX MALE MATERIAL VINYL CHLORIDE D05E CONCENTRATION 100 PPM DURATION OP DOSAGE | SPECIES pIOTJSE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) NECROPSY* GROSS PATHOLOGY REPORT no c\<~dl5 ^J) PATHOLOGY NUMBER 76-11780 CHARGE NUMBER 177-0007700 SAVE TISSUES yes ET no ROOM HET K-1711-(22) \ -3^11 CAGE ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM |]g fi ^ INJECTION (IP. IM, ETC.) PHOTOGRAPHED DATE O W MODE OF DEATH - CO PATHOLOGIST *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY m EQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 66 SEX MALE material VINYL CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE 1 SPECIES pIOUSE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) NECROPSY* GROSS PATHOLOGY REPORT O O C\Ct3S3 V___ ) pathology number 76-11779 charge number 177-0007700 SAVE TISSUES ROOM yes NO HET K-1711-(22' DATE CAGE 6 V-\ f* . AV'-' C-S- ROUTE OF ADMINISTRATION DIETARY 0JNHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE MODE OF DEATH m go (/) GO --A CO CO 03 PATHOLOGIST *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS J DOW - TOXICOLOGY !EQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUNT Ear mark 65 SEX MALE MATERIAL VINYL CHLORINE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE SPECIES MOUSE number of doses TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT PATHOLOGY number 76-11778 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM 1 1 YES (XI N0 T NUMBER HET K-1711-(22) \'3I'T? CAGE ROUTE OF ADMINISTRATION DIETARY 0" INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED NECROPSY* cs> C\C05S v''" -- c-e_ MODE of death 37 80 CO o CO -J. CO CO CO PATHOLOGIST *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS y t coamyi DOW - TOXICOLOGY REQUEST FOR PATHOLOGY REQUESTED BY DTHALATION STUDY EAR MARK 64 SEX MALE material VINYL CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE SPECIES MOUSE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT PATHOLOGY NUMBER 76-11777 CHARGE NUMBER 177-0007700 SAVE TISSUES Dyes CH no ROOM T NUMBER ,, HET K-1711-(22) 3-1-11 CAGE ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE NECROPSY* TVt~ j no(M'lll'K'CA.I tjco-SA J-hllf ^. TX5e// MODE OF DEATH PATHOLOGIST DO R W o co UL o o * THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY REQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY Lar mark 63 SEX MA.1E MATERIAL VlfTYl CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE SPECIES MOUSE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) NECROPSY* GROSS PATHOLOGY REPORT n\ c^ntn^o^.1 PATHOLOGY NUMBER 76-11776 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM yes Dno HET K-1711-(22) OATE 3-1-11 CAGE ) ao ) ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE MODE OF DEATH jg go W CO >1 O-ft. PATHOLOGIST the FOLLOWING TISSUES WERE examined and unless noted above no VISIBLE LESIONS [NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY W EQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 62 SEX MALE SPECIES MOUSE MATERIAL TITO CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE NUMBER OF boils TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT PATHOLOGY NUMBER 76-11775 CHARGE NUMBER 177-0007700 SAVE TISSUES yes Dno ROOM HET K-1711- ( 22) DATE <?-/-11 CAGE ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLI5M INJECTION (IP, IM, ETC.) PHOTOGRAPHED NECROPSY* O^IT\ I ^ ^ ^n=>i'5 MODE OF DEATH > ~TBe.ll J-/-77 33 fi CO o CO oro PATHOLOOIST the following tissues were examined and unless noted above no VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS 7 DOW - TOXICOLOGY REQUEST FOR PATHOLOGY Requested by INHALATION STUDY EAR MARK 61 SEX MALE SPECIES MOUSE pathology number 76-11774 CHARGE number 177-0007700 SAVE TISSUES 1 1 YES n NO ROOM T NUMBER HET K-1711-(22) DATE 3- i-n CAGE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE NUMBER OP DOSES TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED NECROPSY* ^xirw jcxn'VvNcO no ^ roj j <Zxe"*v' 773e// MODE OF DEATH 30 fio (f) O CO _A b o CO PATHOLOGIST * the following tissues were examined and unless noted above no visible lesions (nvl) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS J fCDnUT\ DOW - TOXICOLOGY REQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 60 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE SPECIES MOUSE NUMBER op doses TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* PATHOLOGY HUMBER 76-11773 CHARGE NUMBER 177-0007700 SAVE TISSUES s5 CDYES NO ROOM T NUMBER HET K-1711-(22' Date 2--11-11 CAGE ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.)_____________ PHOTOGRAPHED DATE 3-1-77 MODE OF DEATH MF CLAMP DECAP G35AT SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL PATHOLOGIST ViR. P. Oi'lAidvlA D 3D CO o CO o THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS J DOW - TOXICOLOGY .REQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK SEX 59 MADE SPECIES MOUSE PATHOLOGY NUMBER 76-11772 SAVE TISSUES ^YES 1 CHARGE NUMBER 177-0007700 ROOM 1 NO T NUMBER HETK-1711-(22' 2.-Z.2. -11 CAGE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE ROUTE OF ADMINISTRATION DIETARY ^INHALATION ORAL CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. SKIN METABOLISM INJECTION (IP, IM~, ETC.) PHOTOGRAPHED DATE 3-1-77 MODE OP DEATH MF CLAMP DECAP G35Ai X GO NVL O CO --A o cn PATHOLOGIST 1. p. /A lpVAi, 'iiD THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY REQUEST FOR PATHOLOGY PATHOLOGY NUMBER 76-11771 HET K-1711-(22) REQUESTED BY INHALATION STUDY EAR MARK 53 SEX MALE species MOUSE Charge NUMBER 177-0007700 SAVE TISSUES T^Tyes CD NO ROOM 2- '2.2 -11 CAGE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* ROUTE OF ADMINISTRATION DIETARY WjNHALATION ORAL SKIN Q METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED 3-1-77 G35Aj MODE OF DEATH MF CLAMP DECAP SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL 3D CO o co fc. o o> PATHOLOGIST R. P. 3 (~PpjUr . : ^1. * THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, / STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY 1EQUEST FOR PATHOLOGY PATHOLOGY NUMBER 76-11770 i dcr HET K-1711-C22) REQUESTED ST INHALATION STUDY Ear mark 57 SEX MALE SPECIES MOUSE CHARGE NUMBER 177-0007700 SAVE TISSUES (2Lyes D no ROOM DATE 2-'Z7 -77 CAGE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* ROUTE OF ADMINISTRATION DIETARY JZkjNHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE MODE OF DEATH 3-1-77 G35Ai ________ MF CLAMP PECAP SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL zo CO o CO -a o -M pathologist R. P. * THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, 7 STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS (FRONTI DOW - TOXICOLOGY [EQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK SEX 56 MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE SPECIES MOUSE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS* (IF PRESENT) GROSS PATHOLOGY REPORT PATHOLOGY NUMBER 76-11769 CHARGE NUMBER 177-0007700 SAVE TISSUES yes CD no ROOM T NUMBER HET K-1711-(22 ^ DATE / -zV-77 CAGE ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 1-31-77 G16Aj NECROPSY* MODE OF DEATH MF CLAMP DECAP KIDNEY, LIVER, SPLEEN, AND THYMUS WILL BE WEIGHED NVL 3J C to o co -A o 03 PATHOLOGIST (3^5, R.f. SHARMA DVM.PIhD *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL. SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS fppnw'n DOW - TOXICOLOGY REQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY Ear mark 55 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE SPECIES MOUSE number of doses TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT pathology number 76-11768 charge NUMBER 177-0007700 Save tissues ROOM CD^]yes no T NUMBER HET H-1711-(22. Date i-LH-n CAGE ROUTE OF ADMINISTRATION DIETARY 1*1 INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 1-31-77 G16Aj NECROPSY* MODE OF DEATH MF CLAMP DECAP KIDNEY, LIVER, SPLEEN, AND THYMUS WILL BE WEIGHED. NVL 3J So w o CO o CO & P- SHARMA DVM,PhD * THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS icbimiti DOW - TOXICOLOGY 4EQUEST FOR PATHOLOGY equested by INHALATION STUDY EAR MARK 54 SEX MALE SPECIE5 MOUSE, pathology number 76-11767 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM Hyes Dno HET K--1711--(22) /- 2 V - 7 7 CAGE MATERIAL VINYL CHLORIDE 005E CONCENTRATION 100 PPM DURATION OF DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY (^INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED Date 1-31-77 G16Aj NECROPSY* MODE OF DEATH MF CLAMP DECAP KIDNEY, LIVER, SPLEEN, AND THYMUS WILL BE WEIGHED. NVL 30 V) o co mi --i O PATHOLOGIST Ji- orirn*\ji\A VM,PhD lirtlA nDitlTCN o S'! 71 THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS rCEJOKJT) DOW - TOXICOLOGY EQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 53 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE species MOUSE NUMBER OF OOSES TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT PATHOLOGY NUMBER 76-11766 SAVE TISSUES S'yes CHARGE NUMBER 177-0007700 ROOM n no HET K-1711--(22) /- zH'll 1 CAGE 1 ROUTE OF ADMINISTRATION dietary ^ INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) photographed date 1-31-77 G16Aj NECROPSY* MODE OF OEATH MF CLAMP DECAP KIDNEY, LIVER, SPLEEN, AND THYMUS WILL BE WEIGHED. NVL to o CO -P* PATHOLOGIST R. P. SHA.'<MA DVM,PhQ THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS /FpnuTi DOW - TOXICOLOGY ^REQUEST FOR PATHOLOGY Requested by INHALATION STUDY EAR MARK 52 SEX MALE SPECIES MOUSE PATHOLOGY NUMBER 76-11765 CHARGE NUMBER 177-0007700 SAVE TISSUES JZ]yes Dno ROOM HET X-1711-(22' DATE /- /*'77 CAGE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF OOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY JS,I INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED date 1-10-77 G7Aj NECROPSY* MODE OF DEATH MF CLAMP DECAP SPLEEN, LIVER, KIDNEYS, AND THYMUS WERE WEIGHED. THYMUS, KIDNEYS, AND LIVER WERE SAVED FOR HISTOLOGICAL PURPOSES. THE SPLEEN WAS USED FOR CULTURE PURPOSES. NVL X Qo C/J O CO Ca --k ro THOLOOfST T\ _ R. P. SHARMA DVM,PhD pdihtpc) *THE FOLLOWING TI5SUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS y (FRONT) DOW - TOXICOLOGY REQUEST FOR PATHOLOGY QUESTED BT INHALATION STUDY Ear mark 51 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE SPECIES MOUSE number of oos^i TIME SINCE LAST DOSE PATHOLOGY NUMBER 76-11764 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM yes Dno HET K-1711--(22) date )- CAGE (O -T? ROUTE OF ADMINISTRATION DIETARY Inhalation CLINICAL SIGNS- (IF PRESENT) GROSS PATHOLOGY REPORT ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 1-10-77 G7Aj NECROPSY* MODE OF DEATH MF CLAMP DECAP SPLEEN, LIVER, KIDNEYS, AND THYMUS WERE WEIGHED. THYMUS, KIDNEYS, AND LIVER WERE SAVED FOR HISTOLOGICAL EXAMINATION. THE SPLEEN WAS USED FOR CULTURE PURPOSES. NVL 3J to O CO -Ml -u --A CO PATHOLOGIST / R. P. IARMA DVM,PhD FORM CJ2030 PRINTED R.12-73 THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, 5TOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS J (FRONT) DOW - TOXICOLOGY REQUEST FOR PATHOLOGY Requested by INHALATION STUDY EAR MARK SEX 50 MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OP DOSAGE SPECIES MOUSE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* PATHOLOGY NUMBER 76-11763 SAVE TISSUES N-YES CHARGE NUMBER 177-0007700 ROOM CD NO HET K-1711--(22' DATE /-/o-~n CAGE ROUTE OF ADMINISTRATION DIETARY S- INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) photographed DATE 1-10-77 MODE OF DEATH MF CLAMP DECAP G7Aj SPLEEN, LIVER, KIDNEYS, AND THYMUS WERE WEIGHED. THYMUS, KIDNEYS, AND LIVER WERE SAVED FOR HISTOLOGICAL EXAMINATION. THE SPLEEN WAS USED FOR CULTURE PURPOSES. NVL 30 flo CO o CO -M. -A PATHOLOGIST/' 7)^,1 R. P. SHARMA DVM,PhD FOAM C42030 PRINTED R-12-73 *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL. SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS (FRONT) DOW - TOXICOLOGY REQUEST FOR PATHOLOGY (REQUESTED BY F INHALATION STUDY EAR MARK sex 49 MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 100 PPM OURATION OF DOSAGE SPECIES MOUSE Dumber opposes' time since last dose CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT PATHOLOGY NUMBER 76-11762 CHARGE NUMBER 177-0007700 save tissues ROOM FT! YES Dno ( --V 0 HET K-1711-(22 date CAGE ROUTE OF ADMINISTRATION DIETARY ^ INHALATION ORAL SKIN METABOLISM INJECTION (IP. IM. ETC.) photographed date 1-10-77 G7Aj NECROPSY* mode of death MF CLAMP DECAP SPLEEN, LIVER, KIDNEYS, AND THYMUS WERE WEIGHED. THYMUS, KIDNEYS, AND LIVER WERE SAVED FOR HISTOLOGICAL EXAMINATION. THE SPLEEN WAS USED FOR CULTURE PURPOSES. NVL JJ B U) o co fc. -A CJ1 pathologist! TP7='V' R. p. SHARMA DVM,PhD FORM C42Q3Q PRINTED R*12*73 THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, y STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS (FRONT) DOW - TOXICOLOGY EQUEST FOR PATHOLOGY PATHOLOGY NUMBER 76-11786 HET K-1711-(22) EQUESTED BY INHALATION STUDY Ear mark 25 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE SPECIES MOUSE NUMBER OF QOSES TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM D O0.YES n - IO 'll CAGE ROUTE OF ADMINISTRATION DIETARY ^ INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) photographed date 1-10-77 G7Aj NECROPSY* mode of death MF CLAMP DECAP SPLEEN, LIVER, KIDNEYS, AND THYMUS WERE WEIGHED. THYMUS, KIDNEYS, AND LIVER WERE SAVED FOR HISTOLOGICAL EXAMINATION. THE SPLEEN WAS USED FOR CULTURE PURPOSES. 37 So CO O co -A --L o> pathologist R. P. SHARMA DVM,Ph? THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED; TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS / DOW - TOXICOLOGY ;eq UEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 26 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE SPECIES MOUSE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT pathology number 76-11787 SAVE TISSUES 10YES CHARGE NUMBER 177-0007700 ROOM 1 NO T NUMBER HET K-1711-(22) DATE 1 - {0-11 CAGE ROUTE OF ADMINISTRATION DIETARY 5$ INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 1-10-77 G7Aj NECROPSY* MODE OF DEATH MF CLAMP DECAP SPLEEN, LIVER, KIDNEYS, AND THYMUS WERE WEIGHED. THYMUS, KIDNEYS, AND LIVER WERE SAVED FOR HISTOLOGICAL EXAMINATION. THE SPLEEN WAS USED FOR CULTURE PURPOSES. NVL JO to o CO Ca -A -'J PATHOLOGIST R. P. SHARMA DVM,PhD * THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS J DOW - TOXICOLOGY REQUEST FOR PATHOLOGY requested ar INHALATION STUDY EAR MARK 27 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE 1 SPECIES pOTJSE NUMBER OF DOSES time since last dose CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* SAVE TISSUES 0 YES oz pathology number 76-11788 CHARGE NUMBER 177-0007700 ROOM HET K--1711--(22) date I-10 -77 1 CAGE 1 ROUTE OF ADMINISTRATION DIETARY' 0 INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 1-10-77 mode of DEATH MF CLAMP DECAP G7Aj SPLEEN, LIVER, KIDNEYS, AND THYMUS WERE WEIGHED. THYMUS, KIDNEYS, AND LIVER WERE SAVED FOR HISTOLOGICAL EXAMINATION. THE SPLEEN WAS USED FOR CULTURE PURPOSES. NVL PATHOLOGIST r R. P. SHARMA DVM,PhD 00 Bo CO o CO 00 THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS J DOW - TOXICOLOGY REQUEST FOR PATHOLOGY Requested by INHALATION STUDY Ear mark 28 SEX MALE SPECIES MOUSE PATHOLOGY NUM8ER 76-11789 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM 0^es Dno T HUMBER HET K-1711-(22) DATE _ I -10-77 CAGE VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* route of administration DIETARY ^ INHALATION ORAL SKIN METABOLISM INJECTION (IP. IM, ETC.) PHOTOGRAPHED DATE 1-10-77 MODE OF DEATH MF CLAMP DECAP G7Aj SPLEEN, LIVER, KIDNEYS, AND THYMUS WERE WEIGHED. THYMUS, KIDNEYS, AND LIVER WERE SAVED FOR HISTOLOGICAL EXAMINATION THE SPLEEN WAS USED FOR CULTURE PURPOSES. NVL ID CO o co (0 PATHOLOGIST R. P. SHA! k DVM^hJ THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS [NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, / STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY EQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 29 SEX MALE SPECIES MOUSE PATHOLOGY NUMBER 76-11790 CHARGE NUMBER 177-0007700 SAVE TISSUES YE5 CD NO ROOM mjMocn HET K-l711-(22) DATE /'2V-77 CAGE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE NUMBER of DOSES TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* ROUTE OF ADMINISTRATION DIETARY {3 INHALATION ORAL 5KIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 1-31-77 MODE OF DEATH MF CLAMP DECAP G16Aj KIDNEY, LIVER, SPLEEN, AND THYMUS WILL BE WEIGHED. NVL CO PATHOLOGIST R. P. SHARMA DVM,PhD * THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY 4 EQUEST FOR PATHOLOGY PATHOLOGY NUMBER 76-11791 fflEtk-1711- (22) REQUESTED BY INHALATION STUDY EAR MARK 30 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE SPECIES MOUSE HUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* CHARGE NUMBER 177-0007700 SAVE TISSUES ISOTES DnO ROOM / "2 V ' 7 7 cage ROUTE OF ADMINISTRATION DIETARY ^ INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 1-31-77 MODE OF DEATH MF CLAMP DECAP G16Aj KIDNEY, LIVER, SPLEEN, AND THYMUS WILL BE WEIGHED NVL 3} Co o --CO1 t* to PATHOLOGIST R. P. SHARMA DVM,PbD THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY .REQUEST FOR PATHOLOGY *EQUESTED BY INHALATION STUDY Ear mark 31 SEX MALE SPECIES MOUSE PATHOLOGY NUMBER 76-11792 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM [53 YES OnO T NUMBER HET K-1711-(22) 1 DATE 1 /-ZV-77 CAGE material VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE NUMBER of doses TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 1-31-77 G16Aj NECROPSY* MODE OF DEATH MF CLAMP DECAP KIDNEY, LIVER, SPLEEN, AND THYMUS WILL BE WEIGHED. NVL 30 W o CO --1 N> PATHOLOGIST R. ?. SHAR.V1A DVM,PhD the following tissues were examined and unless noted above no VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY [EQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 32 SEX MALE SPECIES MOUSE PATHOLOGY NUMBER 76-11793 SAVE TISSUES CHARGE NUMBER 177-0007700 room 123 YES QnO SET K-1711-(22) DATE /-ZV- 77 CAGE material VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE NUMBER Of DOSES TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY 0. INHALATION ORAL SKIN Q METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 1-31-77 G16Aj NECROPSY* MODE OP DEATH MF CLAMP DECAP KIDNEY, LIVER, SPLEEN, AND THYMUS WILL BE WEIGHED, NVL 27 fio CD O CO --A fcs N> CO PATHOLOGIST R.P. SHARMA DVM,PhD THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY REQUEST FOR PATHOLOGY pathology number 76-11794 i HET K--1711--(22' REQUESTED BY INHALATION STUDY EAR MARK 33 SEX MALE 1 SPECIES prousE CHARGE HUMBER 177-0007700 SAVE TISSUES ]yes no ROOM 7. 'LZ-ll CAGE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE NUMBER OF DOSES time since last DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY ^2 inhalation ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) photographed DATE 3-1-77 G35Aj NECROPSY* MODE OF DEATH MF CLAMP DECAP SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL PATHOLOGIST R. ?. ',\A LV/V\,Pb0 33 (/) O co -P*. ro 4^ * THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY IEQUEST FOR PATHOLOGY PATHOLOGY NUMBER 76-11795 i nungcn HET K-1711-(22) EQUESTED BY INHALATION STUDY EAR MARK 34 SEX MALE SPECIES MOUSE CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM U YES CD NO Z-2-2--"n CAGE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE Dumber of dosH TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY ^ljNHALATION ORAL SKIN METABOLISM INJECTION (IP. IM, ETC.) photographed DATE 3-1-77 G35Aj NECROPSY* SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. MODE OF DEATH MF CLAMP DECAP 37 Co (n NVL 0 CO -A ro 01 PATHOLOGIST R. ?. 3HA;3V.A DVM,PhO THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED; TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY REQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 35 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE SPECIES MOUSE NLJMSTR OP DOSES TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT! GROSS PATHOLOGY REPORT PATHOLOGY NUMBER 76-11796 charge number 177-0007700 SAVE TISSUES ROOM [Sjes CD no T NUMBER HET (22)K-1711- 'L-ZL-ll CAGE ROUTE OF ADMINISTRATION DIETARY & INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED 3-1-77 G35Aj NECROPSY* mode of death MF CLAMP DECAF SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED, NVL JJ (/> o CO ro 0 pathologist R. P. Si-iA.LVA i3VM,;:hD * THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY REQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 56 SEX MA.LE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE SPECIES MOUSE NUMBER Qf^ DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* PATHOLOGY NUMBER 76-11797 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM HU0LyES NO T NUMBER HET K-1711--(22) DATE 2. '11 ''l'1 CAGE ROUTE OF ADMINISTRATION DIETARY H-INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.)______________ PHOTOGRAPHED DATE 3-1-77 G35Aj MODE OF DEATH MF CLAMP DECAP SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED, NVL 30 </> o co -A rofit 'nI enou r-T7ft10 OOiwTPft THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED; TRACHEA, LUNG, HEART, LIVER, KIDNEYS. ADRENAL, SPLEEN, PANCREAS, / STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS (FRONT) DOW - TOXICOLOGY 4EQUEST Ire quested sr FOR PATHOLOGY INHALATION STUDY ear mark 37 SEX MALE SPECIES MOUSE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSACE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT PATHOLOGY NUMBER 76-11798 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM yes Dno HET K-1711-(22) DATE 3-I-11 cage ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) photographed NECROPSY* ni (? Ko- kv-\ , <a_/ ) no (J)ro5-s MODE OF DEATH PATHOLOOIST cORm C-02030 printf 0 R-12.73 X R> CO o CO to CD *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS (FRON r DOW - TOXICOLOGY 4EQUEST FOR PATHOLOGY QUESTED BY INHALATION STUDY EAR MARK 38 SEx MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE SPECIES MOUSE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) NECROPSY* GROSS PATHOLOGY REPORT o- n < ^ ^ 1 PATHOLOGY NUMBER 76-11799 Charge number 177-0007700 SAVE TISSUES ROOM OyES 1 1 NO T NUMBER HET K-1711-(22) 3-1-11 CAGE ROUTE OF ADMINISTRATION DIETARY INHALATION _ ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE ?c CO 2 --* N> ) MODE OF DEATH J ^ TtJ-el 3-1-1 1 pathologist fOpm C*32030 Printed *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS (FRONT) DOW - TOXICOLOGY REQUEST FOR PATHOLOGY Houested by w INHALATION STUDY EAR MARK 39 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE SPECIES MOUSE NUMBER of doses time since last dose CLINICAL SIGNS- (IF PRESENT) GROSS PATHOLOGY REPORT PATHOLOGY NUMBER 76-11800 SAVE TISSUES yes CHARGE NUMBER 177-0007700 ROOM Dno T NUMBER HETK-1711-(22) DATE 3- i-ll CAGE ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED NECROPSY* i c-| Ao mode of death ro s 3 Pacol kk 7~8eil 3-l-~n 33 99 (I) O 00 _A 4* CO o pathologist FORM C-32030 PRINTED R-12-2J * THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, 5MALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS (FRONT) DOW - TOXICOLOGY REQUEST FOR PATHOLOGY jeiMLLATION STUDY Ear mark 40 SEX MALE SPECIES MOUSE PATHOLOGY NUM0ER 76-11801 CHARGE NUM&ER 177-0007700 SAVE TISSUES 1 I YES 1 1 NO ROOM nyyiBtn HET K-1711-C22) 3-I'll CAGE eYiUYD CHLORIDE DOSE CONCENTRATION 10 PPM duration of dosage NUMBER of doses time since last dose CLINICAL SIGNS - (IF PRESENT) NECROPSY* GROSS PATHOLOGY REPORT CX. n \ I v. K\ Li J . Tl3e l) ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE MODE OF DEATH J- 3J w o CO Ck CO PATHOLOGIST *0RM C*J20JO PRINTED R.12-73 *THE FOLLOWING TISSUES WERE EXAMINED ANO UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS (FRONTS DOW - TOXICOLOGY REQUEST FOR PATHOLOGY quested Sr nrHALATION STUDY EAR MARK 41 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE SPECIES MOUSE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL (IF PRESENT) GROSS PATHOLOGY REPORT PATHOLOGY NUMBER 76-11802 CHARGE numSER 177-0007700 SAVE TISSUES ROOM yes -0NO HET K-1711-(22) OATE 1'3 I'T? CAGE ROUTE OF ADMINISTRATION DIETARY ^INHALATION ORAL SKIN |_J Mfc lAtJULlbM INJECTION (IP, IM, ETC.) photographed date NECROPSY* Ao acoss sy\ee a mode of death 00 CD o CO -A CO CO PATHOLOGIST FORM CJ2O30 PRINTED R-U.73 the FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS (fron DOW - TOXICOLOGY REQUEST FOR PATHOLOGY REQUESTED 3Y INHALATION STUDY EAR MARK 42 sex MALE MATERIAL VINYL CHLORIDE dose concentration 10 PPM duration of dosage species MOUSE number of doses TIME SINCE LAST 005E CLINICAL SIGNS * (IF PRESENT) GROSS PATHOLOGY REPORT SAVE TISSUES yes! PATHOLOGY NUMBER 76-11803 CHARGE NUMBER 177-0007700 ROOM HET K-1711--(22. 3\-Tl CAGE ROUTE OF ADMINISTRATION DIETARY Q'INHALATION 0 ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE ^ NECROPSY* f\0 <\cOSS .) C^O\W\ _ S^\^ey> 1) . C r- MODE OF DEATH PATHOLOGIST FORM C-32030 PAINTED R.12.73 u Co w o co ~A PA CO CO * THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS (FRONT) DOW - TOXICOLOGY EQUEST FOR PATHOLOGY BTeOUESTEP 8Y INHALATION STUDY EAR MARK 43 SEX MALE SPECIES MOUSE PATHOLOGY NUMBER 76-11804 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM yes 0NO T NUMBER HET K-1711-(22) DATE \- 3I-T1 CAGE VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE NUMBER OF DOSES time since LAST DOSE CLINICAL SIGNS - (IF PRESENT) NECR0P5Y* GROSS PATHOLOGY REPORT c\co$5 l) -3 t'erx ROUTE OF ADMINISTRATION DIETARY 0. INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) photographed Date MODE OF DEATH JO JJO 0) r- CaP a W PATHOLOGIST OluTCK Q | 1 y- THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, ,,/ STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS (fontsi t\ DOW - TOXICOLOGY REQUEST FOR PATHOLOGY Pequested by INHALATION STUDY EAR MARK 44 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE SPECIES MOUSE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT PATHOLOGY NUMBER 76-11805 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM yes IZIno T NUMBER HET K-1711-(22) DATE CAGE route of administration DIETARY ^.INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.)_____________ PHOTOGRAPH0 NECROPSY* Y'v o & rosi O <s.xro-- _so\-eev^ CuWuft mode op death 33 0) o 03 a * 03 Ul PATHOLOGIST J*THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS (Front DOW - TOXICOLOGY EQUEST FOR PATHOLOGY Requested by INHALATION" STUDY EAR MARK A5 SEX MALE MATERIAL Vim, CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE SPECIES MOUSE NUMBER OF DOSES TIME SINCE LAST DOSE clinical SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* PATHOLOGY NUMBER 76-11806 CHARGE NUMBER 177-0007700 SAVE TISSUES D O/&YES n ROOM HET K-1711-(22) DATE -l.-v-i.-T CAGE ROUTE OF ADMINISTRATION DIETARY "fa INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.)_____________ photographed 3-1-77 G35AJ MODE OF DEATH MF CLAMP DECAP SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL cn o CO -fA. CO or PATHOLOGIST R. P. SHAR/AA D\?A,PhD THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTEO ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS rpDOKJT' DOW - TOXICOLOGY EQUEST FOR PATHOLOGY EQUESTED BY INHALATION STUDY EAR MARK 46 SEX MALE SPECIES MOUSE PATHOLOGY NUMBER 76-11807 SAVE TISSUES [y^yes CHARGE NUMBER 177-0007700 ROOM NO T NUMBER HET K-1711-(22) LZ'll CAGE material VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY JS}_ INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.)______________ PHOTOGRAPHED 3-1-77 G35Aj NECROPSY* MODE OF DEATH MF CLAMP DECAP SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL 30 Co CO O CO A CO N PATHOLOGIST R..P "*.4 SJ i J~\ \r.\ g-l $ 1 d cn 0.1 THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS J (FRONTl DOW - TOXICOLOGY REQUEST FOR PATHOLOGY "requested by INHALATION STUDY EAR MARK 47 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE SPECIES MOUSE NUMBER of ooses TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT pathology number 76-11808 SAVE TISSUES [SyES 1 Charge number 177-0007700 ROOM 1 NO t number HET K-1711- (22) DATE 2.' 22 'T CAGE ROUTE OF ADMINISTRATION DIETARY J34NHALATI0N ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 3-1-77 G35Aj NECROPSY* MODE OF DEATH MF CLAMP DECAP SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL PATHOLOGIST R. P. SHA&WA DVM,PhD 30 e CO o co _A 4* CO 00 lE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS feonui DOW - TOXICOLOGY REQUEST FOR PATHOLOGY PeOUESTED 8Y INHALATION STUDY EAR MARK 48 SEX MALE 1 SPECIES f-IOUSE material VINYL CHLORIDE DOSE CONCENTRATION 10 PPM duration of oosage NUMBER OF DOSES TIME SINCE LAST DOSE clinical SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* PATHOLOGY NUMBER 76-11809 CHARGE HUMBER 177-0007700 SAVE TISSUES ROOM D0yes no T NUMBER HET K-1711-(22) DATE CAGE ROUTE OF ADMINISTRATION DIETARY S3 INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.)_____________ PHOTOGRAPHED DATE 3-1-77 G35Aj MODE OF DEATH MF CLAMP DECAP SPLEEN, KIDNEYS, LIVER, AND THYMUS WILL BE WEIGHED. NVL DO B CO o CO -E* CO CO PATHOLOGIST . P. SHAmVvA i3v;vv,r7iD F0RM CJ2030 PRINTED R.12-73 * THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTE5TINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS (FRONT) DOW - TOXICOLOGY REQUEST FOR PATHOLOGY ^REQUESTED by INHALATION STUDY EAR MARK 1 SEX MALE MATERIAL VINYL CHLORIDE 00S CONCENTRATION 0 PPM DURATION OF DOSAGE SPECIES RABBIT 3ES OF Dosei TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT PATHOLOGY NUMBER 76-11810 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM Dies Dko HET K--1711-( 22 DATE z-zrii CAGE ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP. IM. ETC.) PHOTOGRAPHED DATE 3-1-77 G37Aj NECROPSY* mode of death CO2 -DECAP A BLOOD SAMPLE WILL BE COLLECTED FROM SEVERED CERVICAL VESSELS FROM EACH ANIMAL. Externally Examination of the left pectoral limb revealed an abscessed area on the dorsal aspect of the metacarpal region. This was the apparent site of which an antibody reaction had been conducted. This animal- has an area in which the skin has been shaved on the lateral aspect of the thoracolumbar junction. This is a place where an immune assay had been conducted. '.i Lungs - had blood that had been aspirated during the process of decapitation. JJ fio cn o CO U o MICROSCOPIC EXAMINATION* 76-11810 Liver NVL Kidney NVL Brain NVL Adrenal NVL Spleen NVL Lymph Node NVL Thymus NVL Heart NVL Lung Congestion ID U) C*1 DATS 6-6-77 Hand ifcltten pathologist DATE 6-10-77 c-FORM 32030 PRINTED IN U.S.A. 10-68 * UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN, EMBEDDED DOW - TOXICOLOGY REQUEST FOR PATHOLOGY fQUESTED BY INHALATION STUNT EAR MARK 2 SEX MALE SPECIES RABBIT 1 SAVE TISSUES 1 Dyes O PATHOLOGY NUMBiR 76-11811 CHARGE NUMBER 177-0007700 ROOM T NUMBER HET K-1711-(22) DATE z CAGE MATERIAL VINYL CHLORINE DOSE CONCENTRATION 0 PPM DURATION OF DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 3-1-77 G37AJ NECROPSY* mode of death co2 - decap A BLOOD SAMPLE WILL BE COLLECTED FROM SEVERED CERVICAL VESSELS FROM EACH ANIMAL. nternally Lungs - had some aspirated blood. There are no other visible lesions. xternally This animal has an area in which the skin has been shaved on the lateral aspect of the thoracolumbar junction. This is a place where an immune assay had been conducted. 27 to o co U fo MICROSCOPIC EXAMINATION* 76-11811 Liver NVL Kidney NVL Brain NVL Adrenal NVL Spleen NVL Lymph Node NVL Thymus NVL Heart NVL Lung Congestion DATE 6-6-77 Ulna-- Written PATHOLOGIST1 S* ............. DATE ->0-77 form c* 33030 printed in u.s.a_ 10-63 * UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN, EMBEDDED i l i mmeeui mir> fTnuen u t c la DOW - TOXICOLOGY REQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 3 SEX MALE SPECIES RABBIT PATHOLOGY NUMBED 76-11812 SAVE TISSUES yes CHARGENUM8ER 177-0007700 ROOM Ono HET K-1711-(22' DATE 2--77-7? CAGE material VINYL CHLORIDE DOSE CONCENTRATION 0 PPM duration of dosage NUMBER OF DOSES TIME since last dose CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 3-1-77 G37Aj NECROPSY* MOOE OF DEATH C02 " DECAP A BLOOD SAMPLE WILL BE COLLECTED FROM SEVERED CERVICAL VESSELS FROM EACH ANIMAL. Externally The dorsal aspect of the metatarsal region on the left pectoral limb, had an area of swelling and inflammation. It was the apparent site at which an immune assay had been conducted. This animal has an area in which the skin has been shaved on the lateral aspect f the thoracolumbar junction. This is a place where an immune assay had been conducted. In ally Lungs - had scattered, reddened areas which were firm upon palpation. These range from pinpoint up to 1 cm or larger in diameter. This may have represented aspirated blood during decapitation, however, this should be evaluated histologically in view of the rather firm appearance upon palpation. MICROSCOPIC EXAMINATION* 76-11812 Liver Leukocytic infiltration Kidney NVL Brain NVL Adrenal NVL Spleen NVL Lymph Node NVL Thymus NVL Hear t NVL Lung Congestion 3) CO o CO -c* OT 6-6-77 Hand Written PATHOLOGIST -------. DATE FORM c- 3M30 PRINTED in u.iA, io-M * UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN, EMBEDDED /O A DOW - toxicology mEQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY Ear mark 4 SEX MALE SPECIES RABBIT pathology number 76-11813 CHARGE NUMBER 177-0007700 SAVE TISSUES iL--Ji yes rLiJno ROOM T NUMBER HET K-1711-(22' Date , 2-21-7? CAGE material VINYL CHLORIDE DOSE CONCENTRATION 0 PPM DURATION OF DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 3-1-77 G37Aj NECROPSY* MODE OF DEATH C02 - DECAP A BLOOD SAMPLE WILL BE COLLECTED FROM SEVERED CERVICAL VESSELS FROM EACH ANIMAL. Externally The left pectoral limb in the metatarsal region, had an area of inflammation where an immune reaction had been conducted. Ears - the right ear canal had an accumulation of necrotic debris within it. ^ This animal has an area in which the skin has been shaved on the lateral aspect of the W thoracolumbar junction. This is a place where an immune assay had been conducted. In nally Lungs - had multiple aggregations of aspirated blood, apparently induced during the killing process. 33 CO O 00 P* O) MICROSCOPIC EXAMINATION* 76-11813 Liver NVL Kidney- NVL Brain NVL Adrenal NVL Spleen NVL Lymph Node NVL Thymus NVL Heart NVL Lung Congestion 3J fio to o co --a 4^ N/ DATE '6-6-77 Hand Written paYhologist PATE 6- /o-77 FORM c- 32030 PRINTED IN U.J.A. 10-SI * UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN, EMBEDDED DOW - TOXICOLOGY EQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 5 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION o ppm DURATION OF DOSAGE SPECIES RABBIT NUMBER OF DOSES" TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT PATHOLOGY NUMBER 76-11814 SAVE TISSUES CHARGE NUMBER 177-0007700 ROOM yes Dno HETK-1711-(22] DATE z-zs'-'n CAGE ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED 3-1-77 G37Aj NECROPSY* mode of death co2 - DECAP' A BLOOD SAMPLE WILL BE COLLECTED FROM SEVERED CERVICAL VESSELS FROM EACH ANIMAL. Externally Nasal Turbinates - had accumulations of purulent material, suggestive of pasteurellosis This animal has an area in which the skin has been shaved on the lateral aspect of the thoracolumbar junction. This is a place where an immune assay had been conducted. Int^Btelly Lungs - had multiple, firm, reddened areas which were the result of overexposure to C02- Spleen - appeared to be slightly increased in size. Adrenal Glands - the left adrenal was slightly increased in size. It had a focal area of cortical nodular hyperplasia, approximately 2 mm in diameter. X fi (/) CO --A -u CO MICROSCOPIC EXAMINATION* 76-11814 Liver NVL Kidney NVL Brain NVL Adrenal NVL Spleen NVL Lymph Node NVL Thymus NVL Heart NVL Lung Congestion 30 </> O to (> DATE 6-6-77 Hand Written PATHOLOGIST 6-/c>'77 FORM C- 32030 PRlNTEO IN U.S.A. 10-66 * UNLESS -OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN, EMBEDDED DOW - TOXICOLOGY REQUEST FOR PATHOLOGY PATHOLOGY NUMBER 76-11815 T NUMBER HET K-1711-(22, "requested ST INHALATION STUDY Ear mark 16 SEX MALE MATERIAL YINYL CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE SPECIES RABBIT NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM nes Dno cage ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKI N METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 3-1-77 MODE OF DEATH C02 - DECAP G37A?, A BLOOD SAMPLE WILL BE COLLECTED FROM SEVERED CERVICAL VESSELS FROM EACH ANIMAL. Externally This animal has an area in which the skin has been shaved on the lateral aspect of the thoracolumbar junction. This is a place where an immune assay had been conducted. Internally Popliteal Lymph Nodes - appeared to be slightly decreased In size. Spleen - had a small retention-type cyst extending off of the border. This cystic structure was approximately 2 mm in diameter and contained a clear fluid. JO CO o co --A Ca Or O TISSUE process~checkT^t CUT DOWM EmBEDOcO SECTIONED STAINED FILED JNITIALS DATE KL. 1 s PATH0L1 V*/r7 JRichajrdJ. avocado, LlY-M., *THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS /en^uT' MICROSCOPIC EXAMINATION* 76-11815 Liver NVL Kidney NVL Brain NVL Adrenal NVL Spleen NVL Lymph Node NVL Thymus NVL Heart NVL Lung No tissue 33 (/) o w -s* cn DATE 6-6-77 Hand Writ Leu PATHOLOGIST DATE -/o-77 FORM C- 13030 PRIKTEO IN O.LA, 10-61 * UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN, EMBEDDED DOW - TOXICOLOGY .REQUEST FOR PATHOLOGY requested by INHALATION STUDY EAR MARK 17 SEX MALE material VINYL CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE SPECIES RABBIT NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* PATHOLOGY NUMBER 76-11816 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM 11--___ 1| YES 1--1_1| NO HET K-1711-(22) -2. 2j-ri CAGE ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) photographed 3-1-77 MODE OF DEATH C2 - DECAP G37Aj A BLOOD SAMPLE WILL BE COLLECTED FROM SEVERED CERVICAL VESSELS FROM EACH ANIMAL. Externally The dorsal metacarpal region of the left pectoral limb appeared inflamed. This was the sight at which an immune assay had been conducted. Ear Canals - both had some necrotic debris within the lumen. This animal has an area in which the skin has been shaved on the lateral aspect of the thoracolumbar junction. This is a place where an immune assay had been conducted. In rnally Lungs - have scattered, reddened areas which were the sights of aspirated blood as a result of CO2 exposure and subsequent decapitation. Liver - examination of one of the medial lobes adjacent to the gall bladder revealed an irregular area of paleness. This was approximately 1.5 xe_1 cm in diameter. This is similar to that which has been noted as a spontaneous entity in dictation of livers on control rabbits on previous occasions. The lateral lobe of the liver contained what appeared to be an indication of the possible linear area of paleness approximately 1 cm in width x 3 mm in length. This same lateral lobe of the liver has a circumscribed pale focus approximately 1 mm in diameter, visible near the trailing edge. 23 CO O CD -A -Ca cn N5 MICROSCOPIC EXAMINATION* 76-11816 Liver Leukocytic infiltration Kidney NVL Brain NVL Adrenal NVL Spleen NVL Lymph Node NVk Thymus NVL Heart NVL Lung Congestion and leukocytic infiltration. 3) 01 o 03 cPn* 03 DATE 6-6-77 Hand -Writ-Ten PATHOLOGIST DATE FORM C- 33030 PRINTED IN U.S.A. 10-M * UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN, EMBEDDED 77 DOW - TOXICOLOGY .REQUEST FOR PATHOLOGY Requested a* INHALATION STUDY EAR MARK 18 SEX MALE SPECIES RABBIT MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAOE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS- (IF PRESENT) GROSS PATHOLOGY REPORT PATHOLOGT NUMBER 76-11817 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM n yes NO HET K-1711-(22' date 4age LX' 1 1 ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP. IM, ETC.) PHOTOGRAPHED date 3-1-77 G37Aj NECROPSY* MODE OF DEATH C02 - DECAP A BLOOD SAMPLE WILL BE COLLECTED FROM SEVERED CERVICAL VESSELS FROM EACH ANIMAL. Externally This animal has an area in which the skin has been shaved on the lateral aspect of the thoracolumbar junction. This is a place where an immune assay had been conducted. Internally Lungs - have scattered, reddened foci which were sites of red blood cells as a result of C02 overdose and subsequent death. 37 cn o CO --A b cn -fe MICROSCOPIC EXAMINATION* 76-1-1817 Liver NVL Kidney- NVL Brain NVL Adrenal NVL Spleen NVL Lymph Node N1 Thymus NVL Heart NVL Lung NVL JJ 10 o w u cn in 6-6-77 Hand Mrit ten FORM c- 32030 printeo in U.S.A. 1<hh * UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN, EMBEDDED DOW - TOXICOLOGY REQUEST FOR PATHOLOGY requested BY f INHALATION STUDY EAR MARK 19 sex MALE SPECIES RABBIT PA THOLOG T NUMBER 76-11818 SAVE TJ55UE5 CHARGE NUMBER 177-0007700 ROOM yes Dno T NUMBER HET g-1711-(22' Oat 2 7.1-77 CAGE MATERIAL Vim CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) PHOTOGRAPHED DATE 3-1-77 G37Aj NECROPSY* MODE OF DEATH C02 - DECAP A BLOOD SAMPLE WILL BE COLLECTED FROM SEVERED CERVICAL VESSELS FROM EACH ANIMAL. Externally This animal has an area in which the skin has been shaved on the lateral aspect of the thoracolumbar junction. This is a place where an immune assay had been conducted. Internally Lungs - had a circumscribed red foci which appeared to be red blood cells as a result of decapitation. 33 W coo --A tn CT) MICROSCOPIC EXAMINATION* 76-11818 Liver NVL Kidney NVL Brain NVL Adrenal NVL Spleen NVL Lymph Node NVL Thymus NVL Heart NVL Lung Congestion 30 CO o 03 _a F* (Ji "4 DATE 6-6-77 Hand Written FORM O 32030 PRINTEO IN U.S.A. 10-64 * UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN, EMBEDDED , y" DOW - TOXICOLOGY m.EQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 20 SEX MALE SPECIES RABBIT MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 1000 PPM DURATION OF DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT pathology number 76-11819 SAVE TISSUES yes CHARGE NUMBER 177-0007700 ROOM ) T NUMBER HET K-1711-(22) 2- -ir-i 1 CAGE ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) photographed DATE 3-1-77 G37Aj NECROPSY* MODE OF DEATH CO, DECAP A BLOOD SAMPLE WILL BE COLLECTED FROM SEVERED CERVICAL VESSELS FROM EACH ANIMAL. Externally Ears - the right ear had a rather large accumulation of necrotic material within the lumen of the ear canal. This animal has an area in which the skin has been shaved on the lateral aspect of the thoracolumbar junction. This is a place where an immune assay had been conducted. Int^Kally Lungs - had scattered red foci indicative of red blood cells accumulating as a result of CO^ overexposure and subsequent decapitation. Liver - the medial lobe adjacent to the gall bladder, had 2 circumscribed pale foci, e, 1 ram in diameter, located on the concave aspect. The lateral lobe of the liver contain what appeared to be 4 pinpoint to 1.5 ram sized pale foci. These are visible on the convex surface of the liver. 00 Co O) o Co --A fe cn Co tissue process check ~ust~ cur down EMBEDDED SECTIONED STAINED FILED INITIALS DATE ~~1Wt 77-- ~^7J P ATHOLOGI5T -rftt Eichard J. Kociba. D.VJYL, PhJ). * THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS MICROSCOPIC EXAMINATION* 76-11819 Liver Kidney Localized abscess-like lesion on the margin. NVL Brain NVL Adrenal NVL Spleen NVL Lymph Node NVL Thymus Pyknotic spaces in cortex. Heart NVL Lung Congestion and peribronchiolar cuffing with leukocytes. 30 (/> o GO --k cn co DATE 6-6-77 Hand PATHOLOGIST (o~ 7 7 form c* 33030 printed in U.S.A. 10-68 * UNLESS OTHERWISE NOTED ALL TISSUES WERE FIXED IN NEUTRAL BUFFERED FORMALIN, EMBEDDED V DOW - TOXICOLOGY ^REQUEST FOR PATHOLOGY REQUESTED BT INHALATION STUDY EAR MARK 11 5E* MALE SPEOES RABBIT PATHOLOGY NUMBER 76-11820 SAVE TISSUES yes CHARGE NUMBER 177-0007700 ROOM Dno i HET K-1711-(22' L-7Jr-n Cage MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE NUMBER OP DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OP ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.)______________ PHOTOGRAPHED DATE 3-1-77 G37Aj NECROPSY* MODE OP DEATH C02 - DECAP A BLOOD SAMPLE WILL BE COLLECTED FROM SEVERED CERVICAL VESSELS FROM EACH ANIMAL. Externally This animal has an area in which the skin has been shaved on the lateral aspect of the thoracolumbar junction. This is a place where an immune assay had been conducted. Lungs - had circumsribed red foci indicative of red blood cells as a result of CO^ ovei exposure and subsequent decapitation. Ear Canals - had accumulations of necrotic debris. 30 So CO O Co --A -Ca O) O PATHOLOGIST /v/| y Richard J. Kociba. D.V.M., PhJX il * THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY ^REQUEST FOR PATHOLOGY REQUESTED Br INHALATION STUDY EAR MARK 12 SEX MALE SPECIES RABBIT PATHOLOGY NUMBER 76-11821 save Tissues yes CHARGE NUMBER 177-0007700 ROOM NO i numutn HET K-1711-C22; DATE Z-21-11 CAGE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OP DOSAGE NUMBER OF DOSES TIME since last dose CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN Q METABOLISM INJECTION (IP. IM. ETC)______________ photographed date 3-1-77 G37Aj NECROPSY* MODE OF OEATH C02 - DECAP A BLOOD SAMPLE WILL BE COLLECTED FROM SEVERED CERVICAL VESSELS FROM EACH ANIMAL. Externally This animal has an area in which the skin has been shaved on the lateral aspect of the thoracolumbar junction. This is a place where an immune assay had been conducted. Int^nally Fat - had a peculiar yellow coloration. This was consistent throughout the subcutaneous and inner aspects of the carcass. 3J R (/) o w <J) PATHOLOGIST Bichard J. Xociba. D.VJffl., PhJX * THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL. SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY m EQUEST FOR PATHOLOGY pathology number 76-11822 I HUMBEK HET K-1711-(22' REQUESTED BY INHALATION STUDY EAR MARK 13 SEX MALE material VINYL CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE 5PECIE5 RABBIT NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* CHARGE NUMBER 177-0007700 save tissues QyE5 dUo ROOM date 2 2J-7? CAGE ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.)_______________ photographed DATE 3-1-77 G37Aj MODE OF DEATH C0? - DECAF A BLOOD SAMPLE WILL BE COLLECTED FROM SEVERED CERVICAL VESSELS FROM EACH ANIMAL. Externally This animal has an area in which the skin has been bhaved on the lateral aspect of the thoracolumbar junction. This is a place where an immune assay had been conducted. Internally Liver - a portion of one of the medial lobes that was adjacent to the gall bladder had an irregular pale area approximately 8x6 mm. Lungs - have scattered red foci which were red blood cells as a result of CO^ over exposure and subsequent decapitation. 30 W o co vli fc. O) N> DOW - TOXICOLOGY REQUEST FOR PATHOLOGY REOUESTED BY INHALATION STUDY EAR MARK 14 SEX MADE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE SPECIES RABBIT NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT PATHOLOGY NUMBER 76-1182? CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM yes Dno HET K-1711-(22 CAGE DO ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN 0) o CO -Ca o> CO METABOLISM INJECTION (IP, IM, ETC.)______________ PHOTOGRAPHED DATE 3-1-77 G37Aj NECROPSY* mode op death C0? - DECAP A BLOOD SAMPLE WILL BE COLLECTED FROM SEVERED CERVICAL VESSELS FROM EACH ANIMAL. Externally This animal has an area in which the skin has been shaved on the lateral aspect of the thoracolumbar junction. This is a place where an immune assay had been conducted. Internally Lungs - had scattered red foci which were red blood cells as a result of CO2 overexposure and subsequent decapitation. Liver - had a circumscribed pale focus 1 mm in diameter on the convex aspect of the lateral lobe of the liver. PATHOLOGIST Eichard J. Aociba. D.V.M, PhJ), * THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY EQUEST FOR PATHOLOGY requested by INHALATION STUDY EAR MARK sex 15 MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 100 PPM DURATION OF DOSAGE SPECIES RABBIT NUMBER OF DOSES TIME SINCE LAST DOSE clinical SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT pathology number 76-11824 SAVE TISSUES CHARGE NUMBER 177-0007700 ROOM yes Dno T NUMBER HET K-1711-(22) date 2 Hr-ll CAGE ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) photographed DATE 3-1-77 G37Aj NECROPSY* MODE OF DEATH C02 - DECAP A BLOOD SAMPLE WILL BE COLLECTED FROM SEVERED CERVICAL VESSELS FROM EACH ANIMAL. Externally The left pectoral limb, at the dorsal aspect of the metacarpal bones, there was a large abscess formation. This was the apparent site at which an immune assay had been conducted previously. It appeared as if the animal had been self-cannibalized in this area. This animal has an area in which the skin has been shaved on the lateral aspect of the thoracolumbar junction. This is a place where an immune assay had been conducted. Internally Lungs - had scattered firm reddened areas within the lungs which were accumulations of red blood cells as a result of CO2 overexposure and subsequent decapitation. 3) {*> (/> O 03 CP 4> PATHOLOGIST ITC^ Richard J. Kociba. D.V.M., Ph-D. THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, 5PLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS y DOW - TOXICOLOGY ^REQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUNT EAR MARK 6 SEX MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE SPECIES RABBIT NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS- (IF PRESENT! GROSS PATHOLOGY REPORT NECROPSY* pathology number 76-11825 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM O OYES NO HET K-1711- ( 22' CAGE ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM. ETC.) PHOTOGRAPHED 3-1-77 G37Aj MODE OF DEATH C0? - DECAP A BLOOD SAMPLE WILL BE COLLECTED FROM SEVERED CERVICAL VESSELS FROM EACH ANIMAL. Externally This animal has an area in which the skin has been shaved on the lateral aspect of the thoracolumbar junction. This is a place where an immune assay had been conducted. IntflMBally Adrenal Glands - had a 1 ram nodule on the surface of one adrenal, brown in color. DO CO o CO -A fcs O) cn PATHOLOGIST P p c \ m * '!<r \ i U* r. ul RLt\itlrt LPY/.i/l .T-P J* THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY .REQUEST FOR PATHOLOGY Requested by INHALATION STUDY EAR MARK SEX 7 MALE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE SPECIES RABBIT NUMBER OF OOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* PATHOLOGY NUMBER 76-11826 SAVE TISSUES CHARGE NUMBER 177-0007700 ROOM 1~1 YES Q NO HET K-1711-(22) DATE `Z'ZT-ii CAGE ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL Q SKIN METABOLISM INJECTION (IP, IM. ETC.) PHOTOGRAPHED DATE 3-1-77 mode OF Death C0? - DECAP G37Aj A BLOOD SAMPLE WILL BE COLLECTED FROM SEVERED CERVICAL VESSELS FROM EACH ANIMAL. Externally This animal has an area in which the skin has been shaved on the lateral aspect of the thoracolumbar junction. This is a place where an immune assay had been conducted. Internally Lungs - have some changes, probably because of aspiration of blood. There are no other lesions. J3 (/) oco A -Da O) O) PATHOLOGIST R. P. uci.-iAruAA DVM,PhD /*THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS CCOAliT) DOW - TOXICOLOGY ^REQUEST FOR PATHOLOGY requested sy INHALATION STUDY EAR MARK 8 SEX MALE SPECIES RABBIT pathology number 76-11827 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM Dyes O no HET K-1711-(22: DATE Z-21-7? CAGE MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP. IM, ETC.)______________ PHOTOGRAPHED DATE 3-1-77 G37Aj MODE OF DEATH C0? - DECAP A BLOOD SAMPLE WILL BE COLLECTED FROM SEVERED CERVICAL VESSELS FROM EACH ANIMAL. Externally This animal has an area in which the skin has been shaved on the lateral aspect of the thoracolumbar junction. This is a place where an immune assay had been conducted. Internally Lungs - had small brown nodules all over the surface. There were more on the medial sic of the surface and sometimes diffused patches. Liver - had 2 approximately 1 cm long pale necrotic areas. DO B (/> o CO 4* CD 'Ll PATHOLOGIST R. F. SHAS/AA DVM,PhD THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVU WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, y STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY EQUEST FOR PATHOLOGY Requested by INHALATION STUDY EAR MARK 9 sex MALE material VITO CHLORIDE oose concentration 10 PPM DURATION OF DOSAGE SPECIES RABBIT NUMBER OF DOSES TIME SINCE LAST DOSE CLINICAL SIGNS - (IF PRESENT) GROSS PATHOLOGY REPORT NECROPSY* pathology NUMBER 76-11828 CHARGE NUMBER 177-0007700 SAVE TISSUES ROOM yes Qno HET K-1711-(22; DATE Z xy-77 Cage ROUTE OF ADMINISTRATION dietary inhalation ORAL SKIN metabolism INJECTION (IP, IM, ETC.) photograph60 date 3-1-77 MODE OF DEATH C09 - DECAP G37AJ A BLOOD SAMPLE WILL BE COLLECTED FROM SEVERED CERVICAL VESSELS FROM EACH ANIMAL. Externally This animal has an area in which the skin has been shaved on the lateral aspect of the thoracolumbar junction. This is a place where an immune assay had been conducted. [eternally NVL PATHOLOGIST R. P. SHARMA1 J3 CO oco OS 00 yTHE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VI5IBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS DOW - TOXICOLOGY REQUEST FOR PATHOLOGY REQUESTED BY INHALATION STUDY EAR MARK 10 1 SEX 1 mile MATERIAL VINYL CHLORIDE DOSE CONCENTRATION 10 PPM DURATION OF DOSAGE SPECIES RABBIT NUMBER OF DOSES time since last DOSE CLINICAL SIGNS (IF PRESENT) GROSS PATHOLOGY REPORT pathology number 76-11829 SAVE TISSUES | | YES CHARGE NUMBER 177-0007700 ROOM d) NO HET K-1711-(22) date 2- zy-~n CAGE 31 ROUTE OF ADMINISTRATION DIETARY INHALATION ORAL SKIN METABOLISM INJECTION (IP, IM, ETC.) photographed "3-1-77 CO o CO Ca o> (0 G37Aj NECROPSY* mode of death C02 - DECAP A BLOOD SAMPLE WILL BE COLLECTED FROM SEVERED CERVICAL VESSELS FROM EACH ANIMAL. Externally This animal has an area in which the skin has been shaved on the lateral aspect of the thoracolumbar junction. This is a place where an immune assay had been conducted. Internally Lungs - showed evidence of aspirated blood because of decapitation and C02 over exposure. All other organs appear to be normal. Liver - on the left lobe, there were a few pinpoint brown foci indicating some necrotic change. PATHOLOGIST R. P. SHAS/AA DVM.PhD FORM C-32030 PRINTED R.12J} THE FOLLOWING TISSUES WERE EXAMINED AND UNLESS NOTED ABOVE NO VISIBLE LESIONS (NVL) WERE OBSERVED: TRACHEA, LUNG, HEART, LIVER, KIDNEYS, ADRENAL, SPLEEN, PANCREAS, J STOMACH, SMALL INTESTINE, LARGE INTESTINE, AND REPRODUCTIVE ORGANS (FRONT)