Document GzonZmb2exzxgLd8vbM3wp1k7

AR226-2841 <^ Material Tested: Copies ton E. I. du Font de Nemours and Company Haskell Laboratory for Toxicology and Industrial Medicine HASKELL LABORATORY REPORT MO. 372-73 8233-2 Material Submitted by: rganic Chemicals Department ackson Laboratory Other Codes ACUTE OBAL TEST Procedure : The test mater ial, as an aqueous so lution, was iidministere'd by in'tragastric intubation to ChR-CD ma Ie rats in l!i ing Ie: doses. Survivors we re sacrificei 14 days 1.ater. 'Livers were removed for analysis. Results: Dose (me/kg)ff 3,400 2,250 1,500 1,000 670 450 Solution cm 15 15 15 15 15 15 Mort;ality** D - 5 d. D - 4 d. D - 8 d. S - 14 d. S - 14 d. S - 14 d. Liver Wt. (g) 22.46 19.16 19.22 L iver Wt. i 00 Body Wt. 7.41 5.74 6.82 Clinical Signs Lethal Doses: Lacrirnation and saliva day of dosing at 2,250 mg/kg; letharg ruffled fur, red-tinged nose and mout chromodacryorrhea and wet perineal ar 1,500 nig/kg a nd above; weight IOFS un death. Monlethal Doses: Lethargy from 3-4 d after dosing at 670 mg/kg and above; fur from 2-4 days after dosing at 1,0 mg/kg; weight loss from 1-3 days. ** D - ( ) d. = Found dead ( ) days after dosing. S - ( ) d. = Sacrificed ( ) days after dosing. Based on product as received. Company Sanitized. Does not conta - 2 - Summary: tfBIB^ff-s slightly toxic when administered orally Co young adult ChR-CD male rats in single Approximate Letha^)ose (AID) is 1,500 mg/kg of body weight. The compound produced liver enlargement which were dosed at 450 ing/kg and above and which were sacrificed after 14 days. MCD:dhg Date: August 21, leport No. 372-73 1973 Report by: /L^c^ji c ' (/ Nancy Oral Toxic Approved by: Company Sanitized. Does net cor.la