Document GmyxX62xkQ0xEvyjvrkJVxO5n

St. lyouls, Mo. - General Offices February p, 1903 D. fl. Hosier - oeneral Offices a. R. Buchanan - General offices P. 0. Benlgnus - General Offlcea Safe Handling of Union Carbide's UNOX Epoxide 801 - Additive for Pyranol A1333B Tf t. 3. ll. McClain - Anniston, Ala. 9^". K 1) /ti>./ > v,. y - 'f'' S We understand that one or both of your plants win shortly bo handling Carbide's UNOX Epoxide 201 In formulating a.E.'a new Pyrajiol A13B3B. Animal toxicity data provided by Union Carbide indicate that the Epoxide (a dicycio-diepoxy carboxylate) has an oral U),;o in rate of approximately 5 arams per kilogram, (about the same as isopropyl alcohol), it did not kill rabbits when applied to the skin in doses up to 10 grama per cllogram indicating that it la not readily absorbed. In appropriate irritation and akin sensitization teste, it was found to be neither an irritant nor a sensitizer. For some reason Carbide then painted the Epoxide on the sk.tr, of mice three times a week for a year. This produced oorae tumor formation and occasional skin cancers in the animals at the point of contact. The Carbide report states: While the evidence lndlcatee that UNOX Epoxide 201 la not a highly active tumor causing agent, the mere fact chat such reactions were demonstrated suggests the need for avoidance of skin contact and the inhalation of mists and fumee by humans. For comparison, it Is felt that UN0X Epo xide 201 la considerably less tumorigenlc than coal tar pitch. Our laboratories have further studies in progress with other samples of UNOX 201 to determine whether the above results wore characteristic only of tits specific sample tested. In the meantime, this produot will bear the following precautionary labeling - kerning1 Prolonged and Repeated Contact Nay Cauae Delayed and Serious Injury to Skin. Do not tot on skin or clothing. Avoid inhalation of vapors or mists. Iri case of contact with skin, wash thoroughly with plenty of soap and water. Remove contaminated clothing and shoeo. Wash thoroughly before reuse,'" M0NS 096 733 In c ovrcirpcmctenee with G.h., the Carbide Kedical D> partmonl litis <.iu that they tnat tn* Pyrsuriol lorciuintiort con- (.ul.iuiii; thio era.on("i-r proaentod no tuj(iOrii.;ai'.xo. tatard. I .hon^l t juu ahoalci on ararc of tne auovc, i:c -or, .~lnce tine ccr-adc Intel tore - 'proio.i,.;ed and repeatcu oe.-.cact iioy o-t.ico Cc layed and acr'-oas injury to the uli'.n ' - r.i^i.l i'Bdto Uii- joeatlon of the. "delayed and oordous injury to c..:ln" J,i.'.;.jiie3. I on. o.-;-a your Arcelor &<parti..; nts will want to aiuiGt on H". jJdisij pro-Lon.-pid and repeated al.ln contact. liPV-f ! (' Ulmer P. Wheeler rtONS 096734