Document Gmwgge9L07nV3zZZ8MGjgOKQv
Te
WASHINGTON WORKS TEFLON DIVISION
Sp-CF
v - [oy = 0%
0
-
ot
a AL2267 1623
Cc: T.
J.
@TJ.
TP..
A. Foster
J. Hegenbarth
Mo Kem W. Raines - M
TL.hisStclherteonnk
- Wilm.
5625
September 28, 1982
To: FROM:
R. J. ZIPFEL
-
"J. G. LOSCHIAVO 9 HK.
AMMONIUM PERFLUOROOCTANOATE (C-8) IN BLOOD OF TEFLON EMPLOYEES
References:
(1) Let8t/e2r5,/82T,. tP.hisPassutbojoerctt,o aJ.ttaGc.heLdo.schiavo, (2) Let7t/e2r9,/82J,. tG.hisLossucbhjieacvto, toattR.achJe.d.Zipfel,
the two rTehfeerepnucreposleettoefrst.his I leitntietrialilsy toestsiummamtaerdizethaatnd40c%ommoefnt on iinnhhaalleedd Cv-a8porvaphoars ifsourretfaaitense:d in the blood. The remaining 60% of
o It is immediately exhaled. e It is inhaled but not absorbed into the body. It is eliminated by the kidneys, intestines, and sweat
glands. It is retained in other body tissues besides blood.
mIy acskaeldculTa.tiPo.nsP.astoHoer,usead HaaskseolmlewhLaatbordaitfofreyrenTtoxiacpoprlooagcihst,buttocarmeevieuwp
wviatphorsitmhiatlaris rerseutlatisn.ed
Hien
tehsetimeantteidrethbeodyf.ractIi,onon oftheinohtahleerd
C-8 hand,
5 g
estimated the fraction of inhaleTd-8 retained only in. the blood. 3
10444-1
.
. 000219
EID080637
. oo
oe2iol
employees IttrahanssfebrerenedesotutimaotfedTEFfLrOoNm,dattahatcolitlecttaekdesonabofuetmal4e20 days
Sdfsoaryse)ts.hteimabUtosedidyngttohtahteeli4fm7oi%rnmauotlfeaihnlahilasflteeddofoCn-a8ccpuaigsmeulratetwtoeadinoefCd-8Pains(ttotoh1re/'2sen=tlie4rt2et0er, it
beforsdatyci.tmiaotniSoinnocfeistoI tsaeolsmteiwbmhoaadttyedwhaitgCeh-er8r,.reitteMnoitssitonnoitmipnosrutbralpnorotidls,yi,ngwhbiotcthhhat caopPnpatrsaotiaoncoshre'ssa
Sinnditchaeteblotohda.t muPcahstoloesrs etshtainmat1e0d0%thoaft inonhlayledaboCu-t8 ovanpeo-rhalifs orfetaiinnheadled
dean-tc8aouvrafaprgooirmngoi.snlyrTehtfeaosiuenredeemsptinliomyatetheeiso.nesntiaPrraeestobrooodruyg.hrescioTnmhcmiesendtissheytihnadatereedmobraesedhumoann
blood to be
C-8 data made. A
bgereactoelrlecetfefdorti-nisordnoewr
bfeoirngmormeadeacctouragtaetheerstismuacthiodnasta.
Attachments
J1G0L4/n4s-w2W
.
000220
5
EID0S0G38
7 agven
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Foster. Schrenk
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- PARKSBG - PARKSBG
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E27 o ii.
pl Thistleton - PPD - PARKSBG J. W. Raines - PPD - M-5625.1
;"' EHbaskePLonLtoatNsoerFow arTroxo RioEcCoonuu ouaryyp,s anvisii
. G.
L.
Kennedy
-
CR&D Tre
L- iHaskeslhlit
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ANDINDUSTRIAL MEDICINE ~~. "+ 1
wind
PE
NR
ELTONRoad, Newark, DELAWARE 19711030 it
ary,
A Ty
hahmeEs yam e bers ate|
pugugt 25, 1982 vp:
:
PERSONAL AND COMPIDENTIAL "ii i "1% "Ti" ip ou wie iET
ons
er
Ss en peel Ea
:
J. G. LOSCHIAVO rn
one CRARR eR EE
f! a : i+' PPbrAORLKYEMRESRBPURROGD"UC2TS:tiDiEf PARTi M5ERNTaESRh. '..idgBI lifLiin. N--iRaiiTEEdsn mEoRe i wn adlidlo vTl,RE
4
TE Re Sa Wl Tenet HEEEEY NSE
Szd Lat LL EAME MONIUMPTENRRFOLMAUNOBRROOOODCTSAEN(CO-A8T)E aPe r EJSREEe Ta
S S27EE %ELF T(eRfeltoenInntiWTooenrfkeofer.resnA)cmemoIntwioyuomouulPred:r:Jfullluiyotkroeo29o,cmtaak1ne9c82as,teevleert[aCtl-e8r]imptioonrtRB.alnot3o:d7 sOuzfgigipenfsireiliiii.diliiiiiiin:a
oN
#5777
tions. Acquisition and interpretation of C-8 blood concentra- iy. fii
tions `in workers is very.important in understanding how the "J "Ui
"30, #0 5%:
human body handles C-8'and how accurately Haskell correlate to'the'human situation.
our To
animal models at #i7:fniii better interprets iiiis
ji
these data,consider the'following modificationssTM (iymovi idl inn
ple
5
i
GE
IE
+
Le
B -
e
Tohfe ac0c.0u0m6ulapptmionblwohoednleivtelwouilsdtbeermmeodrea
"rate"
appro-
Tw Ran
he 2
priate to call it an "average concentration" %
i hig
over the average of 91 days of employment. The average blood level of 0.006 ppm/day x
2 91." .
A hl Lf Lon
days gives the plateau, or steady-state, con- i iii TINIE
centration (0.546 ppm) that more closely
i
Ti
Tre:
represents the dynamic aspects of exposure and |i' SY
elimination.
i
Sr
The calculations assume a voline of aistribution ih
(Vd) equal to the blood compartment only liters). Since C-8 is water soluble and
(5.5 binds
==
= "u' "HF:
oi' if
vporlotuemien,of thteotVadl wbooudlydwaatcetrual(layppbreoxcilmoasteerlyto42.t..he iFe: B+ Af
R
liters/70 kg mnaenn):.
i;
+
aL7
LF
:
g
BETTER THINGS FOR BETTER LIVING.... THROUGH CHENISTAY
.
000221
EID08063Y
5Ta 7S7T7ES. 6. noscE S hiaEvelSR SEEE I SR ARE N SS hREaeIeT RGE `AATuEg)ustSH2E5a,Te19S 82"SR EiE a
Stell UT nS Rati Te
FEUESE LC
. ToTdH th nh
weird
a ca peggEel o
Sf
CSaep
R hI E
po'noreaccurately adsess theretention of C-g TEE
in the body as well as predict blood levels
te
afnotrimcuilpaastceodmmwointlhycuosnetdi.nuteodesltoiwm-alteeveldreuxpgo-sturhee,raEpey pi i~*' i. EY
regimen can be employed..:': `iii.
EE CR rE
"Assumptionsy UC Con
Eg
The bloodlevel, Cp, isat a plateau FHT REY
i(steady-state) concentration' (i.e.y:li lili.
"aebqsuoarlp)itioonNLaUnEdEeAlEiEmLinatLiaoinnappri oxiv matr ely
i` M aii
oh EO
a Zhen vodlumg geof e distriL butiE on, va,EisRinS. T`pEoiT UHETE E
total body water, or 42 liters... i .:iiiiil Sl
Shh. Salah
GrmeedaailTy deoseer(ld/T) isTE0.081 mg/dTaeyt. i T. he iSees
Siam,in l~=i)i"mdhoetiemlaitmeidnfartoiomn&h,allift-elriafteu,rs r 1/2e , 3op8n.So ..HriEltl diL m n
LE REAR
CHAE LT
CU
77ohe
put
individuals The value is 655 days;
could vary considerably. Uden
Tafie iat
i RG
Bere
HERE
CEE
a
Then 7om Goodman and Gilman' (1970):
Be
Fa
Finis All wii.
F SSEpTHa!
EF t TEE rRRTCgr
i TE
@
T1S4aaEEih1/2)
Dy
a L lA pY ra
a
TIER
TT
fie
ERT PPS
Se a tees et pl os ~ solving for 5"
RE
Ta aR ERE ry
LEER
fh
iEFo. TCH ptet ovdr et1/2 .ode.D .1'04.5646smgc/ll/e242e85-0=8 1mdaare
aE per:
TRE
po 4
thems
.. da1y/s2)7 n- k _f
Ak
8 Absorbed
HE
BE RE
a
.
Ena
ELl R 197 lan 1.00
655
100
EE
To
Gat
Ho,
AE
T. s36s0 00..3505
5B5o.
A dol RCREL AgE E
+ Thus, depending on the actual t 1/2, we can estimate
aobnsloyrbtehda.t gTrheiasteirs tihnange3n0e%raolfaagtrmeoesmpehnetriwcitch-8yoiusr
2
neosttimbaetea,blebuttounatciclurwaeteklnyowcaltcheulaatcetuaflractti1/o2nawle will
5 g
absorption.
=
.
I3q
. 000222
EID080640
fi 13.
ar Egnma
6. Loschiavo Whee
=i SeSAEThRR pT lanBN s SaoSd m
3
L oe FE iame
a
pugust 35, i982. Hin
ETLi e Te a a ee e
=
Wi ,
o
`Regarding these calculations and in response
your, suggesinttiheoJnulsy29memorandum,
to l= Tl. i.
iii: iii:
EH
Li
Sao deat eis id nal CEE
hi
i
A s_- o Moremhue mandoldaateaiRs s Rneycessiar,y from GtwSolH:
ER ghESEE
ie
Alia
Sm
SrUT3iEcoufrrpelnatte`aeum(plsotyeeaedsy-fsotratdee)tercmoinncateinotnras
L amB a A ry Hen
B S EEE RlE Ce LINEey
elena STE ne,
enploHyoeloengesr
Lt
e
x
poI sed to CTa -8L{OUIPOLLELE ld ie h SoEha52
F S e E TO T Tfaonrd,dtheeteumriinnaatriyoenxocrfetthieonblroaotde.1E/2R y, s LuEid
Peat
Rig
I
EE EHLECE e : Sn "aWne,alAhYyavsei"speorfftoe hremeddi.srtardiibouchtR eimoincaalndanedffebcitos cohfeCm-i8i:c*a:idaiia l Sieiahts FiRnR
SSeAllEe da iae sBREE Shli L He de R LeaR het
SFE amEeR ie Tod iodi [Tit J= iSai n i Seg nd
FE TT
RR Tt no| WEA A TORY
Shiai aT
E Ga RnEe
SEERA
wla Soa nie: NST aEREe BR JF)arRrEShER oARmCyH,2NR 0)RIBCAOSLTOOGnIOeSRT
[aa(Ee hE pra is
Saal nt
SES aEnRatee UTe STTy a E SU LSeEmA anR,e RIE E RL n| CT n n erT ls50
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000223
[EID080641
7 PERSONAL AND CONFIDENTIAL
..
2
.
"i. Jo
CIC:0J0. AMD. ECrodrmdarney
+ T1.oLA.L FScohsrteenrk
PG.. LT.hisKtelnenteodny - Haskell Lab.
T. P. Pastoor - Haskell Lab.
July 29, 1982
0:
R. J. ZIPFEL
FROM: 97 6. LOSCHIAVD.Q Yof.
. RETENTION OFo AMNo ONIUr M PEs RFLUOReOOpCTLAoNvOeAeTE=(e C-8
records, Uitsinigs edsattzimaftreodm tthheat F4L0A%IR*ofprionghralaemdanCd-8 fvroamporairis sarmeptlaiinnged in the
bfloouordda(tsaeepoaitnttasc.hmenAtl)s.o, Tthheis reastetimoafteC-8is abrsoougrhptisoinncevaritiesis bybased on only
individual. Air C-8 levels are also variable.
.
C-8 absorpDtaitoan onandmaleelsimionnalytiownereas usoebdserdvueedtoin proattentsitauldiesse.x diDfatfaereonnceFsinein pPaorwtdiecrl/eDisspiezer.sio.nIn emaprelaosyeewsheroenlya sweirgenifuisceadntto peolritmioinnatoef tahierbovranreiabCl-e8 oifs cofontianihnaeledd inC-8p.olym"Tehris parretdiuccleeds,bloboldoodC-8retreentteinotnionshoiusldduebetolestshe thaainrbo4r0n%e pinartdiicalmeetesri)zewidlilstrniobtutliiokne.ly Lraeragceh pthaertilculnegs al(vie.eo.l,arparretgiiocnl.es I>t 5ismicirnons tbhleooda.lveoPlraorbabrleygiofnorwhtehries irenahsaolne,d TgaEsFeLsONandFEPvapOopresrataorersabhsavoerbed into the sOpiegrnaitfoircsa.ntly Tower blood C-8 levels than Fine Powder/Dispersion
more than Ac2c0o%rdoifnginhtaoleGd. CL.-8Keancnceudmyu,latHeasskeilnl boLdaybortaitsosruyesTobxeisciodelsogibslto,od.not aRcetcumsutluadtieeds ibyndioctahteer tbhoadty t1i0sstuoes2.0% of inhaled C-8 is pooled or
*FLAIR - Eluoropolymers Laboratory Analysis Information Retrieval.
0885W-1
.
g
.
. EID0S0642
080224
Po
:
-2-
The remaining 40% of inhaled C-8 has 3 potential fates:
It is exhaled back out.
o
It is inhaled but not absorbed into the body.
o
It is eliminated by the kidneys or intestines.
The following additional information is needed to determine more
accurately the fate of inhaled C-8:
o
More blood C-8 data on males who left TEFLON,
.
More blood C-8 data on new male TEFLON employees.
More
Data
blood C-8
on amount
dofataC-8on exncerwetfeedmaloeverTEFa LO2N4-hoeumrplopyeereiso.d
following exposure.
o
Particle-size distribution of airborne polymer particles
containing C-8.
Perform a Haskell Laboratory study using radiolabelled C-8
to determine where and how much C-8 is stored in the body
immediately after exposure.
Data on C-8 content in exhaled air during exposure.
. Attachment
.
JGL/nsw 0885W-2
000225
>
5
[EID080643
LE
CALCULATIONS AND DATA
7 Ln
Operators Blwoiotdh CT-e8ss actchuanmul5a5t0iodnaysratoefs sienrvifcoeur armealeas FifnoelloPwosw:der/Dispersion
0.0093 ppm C-8 in blood/workday
00..00004830 ppppmm CC--88 iinn bblloooodd//wwoorrkkddaayy
0.0022 ppm C-8 in blood/workday
`
X= 0.0060
POepresroantaolrs aidrurisnagmpltehe rseasmueltsperiniodmolaerse: per billion (mpb) C-8 on these
.
<0.03, 0.09, 0.12, 0.12, 0.15, 0.24, 0.24,
0.66, 0.69, 0.73, 0.75, and 1.39
X = 0.46 mpb or 8.2 ug./m3
AAvienraogveermaalne 8 hhaosurd 5,5S0Io 0TE gt m. on f bTlig oaondtwionrkh.is(1$e and inhales - 10 m3 of At a C-8 concentration of 0.46 mpb (8.1 ug./m3), an average male would
inhale 81 ug. of C-8 during an 8-hour shift.
If all C-8 inhaled was retained in the blood, an average male would accumulate C-8 in blood at a rate of:
81 ugS.EToC9-84/AwLorkbdlaood X 10 6
=
0.0147 ppm C-8 in blood
Workday
However, the average daily C-8 accumulation rate we ubserve in new
employees is only 0.0060 2pm WCo-r8kdiany blood. Therefore, ooff!the total
C-8 inhaled, about as %100 = 403) 40% 1s retained in blood.
(1)Radiological Health Handbook, U.S. Department of Health,
ucation, and Welfare; Revised Edition, January, 1970,
(pp. 215 and 216).
g
JGL/nsw 0885W-3
.
8
.
EID080644
00022