Document GmpbJgqMq3xYmq93BeExROv1v

previous research has shown that smoking and Supersedes NTIS/PS-77/0365, and NTIS/PS- nicotine may have an effect on visual functions. 76/0187. Several studies were conducted to determine If smoking and smoking deprivation would have Descriptors: 'Bibliographies, *Vinyl chloride, an effect on the detection of movement by 'Polyvinyl chloride, 'Toxicology, 'Industrial peripheral vision and to determine the effects of medicine, Public health, Epidemiology, Expo smoking and smoking deprivation on time esti sure, Polyvinyl chloride resins, Combustion mation performance. It was found that under products, Sources, Toxicity, Abstracts. levels of low illumination, nonsmokers had a significantly larger peripheral field, that Research is cited on the health hazards from deprived smokers were better than smokers in exposure to vin^Jjjhjorjde and vinyl chloride detecting movement in the periphery of the resins. Studies are included on the epidemiolo visual field and that subjects on a velocity esti gy of Industrial and public exposures to the mation task who had been deprived of smoking compound and its degradation and combustion Lperformed better than smokers. In a study con cerned with relationships between nicotine level and performance, high nicotine smokers products. (This updated bibliography contains 79 abstracts, 10 of which are new entries to the previous edition.) performed better on a movement detection task fthan low nicotine or deprived smokers. On a time estimation task, it was found that nicotine had some adverse effects but, under other con ditions. actually improved performance. (Author) ORNL/TIRC-77/4 PC E13/MF A01 Toxicology Information Response Center, Oak Ridge, Tenn. Health Aspect of Chloroform: A Review and an Abstracted Literature Collection, 1907-- 1877. AD-225 093/4GA PC A02/MF A01 Army Chemical Warfare Labs Army Chemical Center MD S. G. Winslow, and H. B. Gerstner. Dec 77, 252p* Contract W-7405-ENG-26 Cutaneous Application of 1.1 ( Malathlon Powder to Volunteers PHILIP J. GUTENTAG. Jul 59. IZp Rept no. 2290 Distribution limitation now removed. NOTE: Only 35mm microfilm Is available. No microfiche. Descriptors: 'Chloroform, 'Bibliographies, Car cinogenesis, Chemical properties, Metabolism, Reviews, Toxicity. Identifiers: ERDA/990300, ERDA/560305. ERDA/560306. Abstracts. 'Environmental heallh, Toxicology, 'Toxic substances, In- Descriptors: 'Acetylcholine, 'Cholinesterase, dexes(Documentation), Organic solvents. Coatings, Inhibition, 'Insecticides, `Physiology, 'Powders, 'Skin(Anatomy), `Toxicity. For abstract, see ERA citation 03:025611. Identifiers: `Toxic substances. `Maiathion. No abstract available. CONF-771147-1 MF A01 Oak Ridge National Lab., Tenn. Studies with a New Experimental Model In Respiratory Carclnogeneela. P. Nettesheim, and T. Yarita. 1977,27p Contract W-7405- ENG-26 Symposium on the Syrian hamster in toxicolo gy. Cambridge, MA, USA 30 Nov 1977, Portions of document are illegible. Microfiche copies only. Descriptors: Carcinogens. 'Respiratory system, Biological effects. Biological models, 'Carcinogenesis, Carcinomas, Dose-response relationships, Hamsters. Identifiers: ERDA/560305, Neoplasms, Expo sure, Hamsters, Laboratory animals. Experi mental data, 'Urea/N-nitroso-N-methyl. For abstract, see ERA citation 03:025217. COO-3140-3C PC A03/MF A01 Connecticut Univ. Health Center. Farmington. School of Medicine. Toxicology and Metabolism of Nickel Com pounds. Progress Report, December 1,1976-- November 30,1677. F. W. Sunderman, Jr. 15 Aug 77,35p Contract EY-76-S-02-3140 Descriptors: 'Nickel compounds. Metabolism. Rats, Toxicity. Identifiers: ERDA/560305. Laboratory animals. Experimental data, *Toxicology, Toxic sub stances. For abstract, see ERA citation 03:025218. / NNTT11SS//IPS-78/0442/0GA PC N01/MF N01 / National Technical Information Service, Spring- > field. uVa. Toxicity of Vinyl Chloride (A Bibliography with Abstracts). Rept. tor 1969-Apr 78, Pemell W. Crockett. May 78,86p* PB-278 374/4QA Not available NTIS Health Effects Research Lab., Research Trian gle Park, N.C. Role of Time as a Factor In the Toxicity of Chemical Compounds In Intermittent and Continuous Exposures. Part II. Effects Of In termittent Exposure. Journal article. D. L. Coffin. D. E. Gardner, G. I. Sidorenko, and M. A. Pinigan. 1977. lOp EPA/600/J-77/105b Prepared in cooperation with Institute of General and Municipal Hygiene, Moscow (USSR). Pub. in Jnt. of Toxicology and Environmental Health, 3 p821-8281977. Descriptors: 'Nitrogen dioxide. 'Sulfur dioxide. 'Benzene, Toxicology, Laboratory animals. Ex perimental data, Respiration, Air pollution, Tox icity. Exposure, Time series analysis, Chemical compounds. Identifiers: Reprints, 'Air pollution effects(Humans). Because of fluctuations in levels of industrial air pollution linked to weather and other fac tors, a joint U.S.-Soviet research team studied differences in the effect of time in exposures of air-breathing animals to controlled varied con centrations of air pollutants. An experimental model environment was used to investigate the effects of nitrogen dioxide (N02), sulfur dioxide (S02). and benzene (C6H6) in the air environ ment of laboratory animals, with both continu ous and intermittent exposures. Part II con cerns the toxicities of intermittent exposures to C6H6 and N02; three parameters were used. The toxic effects of N02 with Intermittent expo sure were not reduced as was the esse with C6H6. Data are presented to show that Intermit tent exposure to N02 may be more toxic than continuous exposure when short-term peaks of N02 concentrations are involved. PB-278 361/9GA Not available NTIS Health Effects Research Lab., Research Tnan- |le Park, N C. Clinical Studies Div. fncreased Infectlvity with Exposure to Ozone and Sulfuric Add. Journal article, Donald E. Gardner, Frederick J. Miller, Joseph W. Illing, and Jerome M. Kirtz. 21 Apr 77,8p EPA/600/J-77/104 Pub. in Toxicology Letters, vl p59-641977. Descriptors: `Ozone, 'Sulfuric acid. 'Respiratory diseases. `Immunology, Lung. Toxicity, Immunity, Air pollution. Identifiers: Reprints, 'Air pollution effects(Humans), Synergistic effects of air pollu tants. The effects of the combined action of ozone (03) and sulfuric acid (H2S04) aerosol on host Susceptibility to an aerosol of viable microor ganisms were studied. Exposure to 03 (0.196 mg/cu m) was for 3 h, while exposure to H2S04 (0.9 mg/cu m) lasted 2 h. Neither pollutant alone caused a significant Increase in mortality as compared to clean air controls. In those stu dies involving the combined action of the sequential exposure to the two pollutants, there was a statistically significant increase in respiratory infections in the treated group over controls (indicated by per cent mortality) only when the exposure to the oxidant immediately preceded that of the acid. (Copyright (c) Elsevier/North-Holiand Biomedical Press 1977.) PB-278 450/2GA PC A02/MF A01 Health Effects Research Lab., Research Trian gle Park, N.C. Environmental Toxicology Div. Disposition of 14C and/or 74As-Cacodyllc Add In Rats After Intravenous, Intratracheal, or Peroral Admlnlatratlon. Journal article, J. T. Stevens. L. L. Hall, J. D. Farmer, L. C. DiPasquale, and N. Chernoff. Aug 77,9p EPA/600/J-77/107 Pub. in Environmental Health Perspectives, v19 p151-1571977. Descriptors: 'Bioassay, 'Pesticides, 'Herbicides, Arsenic organic compounds. Tox icology. Absorption(Biology), Metabolism, Excretion. Dosage. Parenteral infusions, Rats. Laboratory animals, Ingestion(Bioiogy), Con- centration(Composition), Blood, Tis- sues(Biology), Muscles, Kidney, Liver, Lung, Labeled substances. Erythrocytes. Identifiers: Reprints, 'Cacodylic acid, Pesticide residues, Gavage, Body burdens, Bioaccumula tion. The distribution, excretion, and possible metabolism of (14)C- and/or (74)As-cacodyiic acid, and organoarsenical herbicide, was stu died In rats following a single intravenous injec tion, intratracheal instillation or oral gavage. Male Sherman rats were dosed at levels ranging from 200 mg/kg to 120 micrograms/kg. The ex tent and rate of lung absorption was greater than gastrointestinal absorption. Concentra tions in the liver and whole blood were higher after peroral dosing than intravenous adminis tration. Levels observed in plasma and other tissues were similar after all three routes follow ing the absorptive phase. The percent dose found in the whole blood, red blood cells, and plasma was similar for all doses given by these routes. Less than 0.1-1/2 Of the administered dose was recovered as (14)C02 by any route at 24 hr after administration. Levels in all tissues decreased rapidly, but remained high in whole blood. The red blood cells were found to be the major site of body burden of cacodylic acid. PB-278 527/7GA PC A05/MF A01 National Cancer Inst., Bethesda, Md. Car cinogenesis Program. Bloaasay of Malathlon for Possible Car cinogenicity. Technical rept. Dec 77.98p* NCI-CG-TR-24. DHEW/PUB/NIH- 78-824 Descriptors: `Insecticides, 'Bioassay, 'Pesticides, 'Maiathion, Toxicology, /WwnU UvJ^^frCl^uly 7, 1978 121 CMA. 053652 ( 1 I 5 t 1 b t 1 < ii ll i i < i c i i E I n f