Document Gmk2jZRDwkRwKg5kbb0O8956V

April HlH ,, Nei Being Tested for Carcinogenicity by the Carcinogen ?s4.si_laatinE~ 3; Program, DCCP, NCI." X think that you will find ir considerably easier to use in tracking the progress of a chemical now that the following headings are being used: Table 1 Data Available IA Technical Reports Published IB No Report - Data Insufficient Table II Bioassay Complete -- Reports Have Been Drafted IIA Reports Being Printed IIB Reports in Review Table III Table IV Table V Table VI Bioassay has been Completed and Reports are Being Drafted Histopathology Incomplete Bioassay has Begin but No Chronic Testing Data are Available Chemicals that have Tentatively been Selected for Testing For a variety of reasons. Technical Reports will not be prepared for those compounds listed in Table IA. However, some of thes"? compounds appear under other headings due to retesting, etc. For example, p-Dioxane is under IA and IIA, "Reports Being Printed." Please feel free to call me if you would like further information. Our telephone number is (301) 496-1895. Sincerely, Enclosure Thomas P. Cameron, D.V.M. Assistant Coordinator I or Knvirontnonia1 Cancer, DCCF, NCI see 3-1967 Cl :CAL$ BEING TESTED FOR CARCINC ,ICITY BY THfc CARCINOGENESIS TESTING PROGRAM, DCCP, NCI APRIL 01, 1978 ui CHEMICALS TESTED IN THIS PROGRAM ARE SELECTED ON THE BASIS OF HUMAN EXPOSURE, PRODUCTION LEVELS AND CHEMICAL STRUCTURE. THEY SHOULD NOT BE CONSIDERED AS SUSPECTED CARCINOGENS BY VIRTUE OF BEING IN THE TESTING . PROGRAM. COMPOUNDS ARE LISTED BY THEIR COMMON OR GENERIC NAME, IF THIS IS NOT AVAILABLE, THEN CHEMICAL NAME IS USED. FOR. ADDITIONAL INFORMATION ADDRESS REQUESTS TO: TECHNICAL INFORMATION RESOURCES BRANCH NATIONAL CANCER INSTITUTE, LANDOW BUILDING, ROOM A304-, BETHESDA, see -1 9 6 a CHEMICALS APE ARRANGE ACCORDING TO THEIR TESTING ST*,US WHICH ARE: table I table II TABLE- III TABLE IV TABLE V TABLE VI DATA AVAILABLE IA TECHNICAL REPORTS PUBLISHED IB NO REPORT - DATA INSUFFICIENT BIOASSAY COMPLETE - REPORTS HAVE BEEN ORAFTEO I IA REPORTS BEING PRINTED I IB REPORTS IN REVIEW BIOASSAY HAS BEEN COMPLETED AND REPORTS ARE BEING DRAFTEO HIS TOPATHOLOGY INCOMPLETE BtJASSAY HAS-BEGUN BUT NO CHRONIC TESTING DATA ARE AVAILABLE CHEMICALS THAT HAVE TENTATIVELY BEEN SELECTEO FOR TESTING ABBREVIATIONS USEO IN THIS REPORT ARE AS FOLLOWS: ROUTES OF ADMINISTRATION: FEEO - ORALLY WITH FOOO GAV - ORALLY BY GAVAGE INhAL - INHALATION WATER - ORALLY WITH WATER ANIMALS SPECIES: IJ - INJECTION -IP - INTRAPERITONEAL SP - SKIN PAINTING , H - HAMSTER M - MOUSE R - RAT SIMULTANEOUS CHEMICAL LISTINGS CHEMICALS THAT APPEAR MORE THAN ONCE REPRESENT SEVERAL EXPERIMENTS. cn I see 1969 TABLe I DATA AVAILABLE 1A TtCHNICAL PGPURTS PUBLISHED Nil * CHEMICAL NAME CAS 4 ROUTE SPECIES *NTI S 4 CU3974 CO 766 LU1445 CO 1445 C 0 4 13 7 l.00044 C0L923 COUU77 COU055 C00U99 CQU191 C02686 CtH 718 COJ113 LOU 1 *.4 C0U124 CUU599 COO 135 LU4u2o IUh5GO L- 00 1 80 COi>47 CU Lo38 C0U204 L0U420 CO J. 7 41 C00237 CUU500 COJ 654 C0454o CO 17o3 CO 1752 ACETIC ACID* (ETHYLENE DINITRILOJTETRA* TRISODIUM SALT ACETIC ACID* MTRILOTAIACETIC ACID. NITRILOTRI-, TRISODIUM SALT* MONOHYDRATE ACETIC ACID, NITRlLOTRI-* TRISOOIUM SALT* MONOHYDRATE ACRIDINE* 3*6-DIAMIN0- MONOHYDROCHLORIDE alurin ANTHRAOUINONE* 2-METHYL-l-NITROCAPTAN CHLORAMBEN LHL0R0AN6 CHLJRD ECONE CHLOROFORM DAPSONE OICHLOROVOS DIELDRIN DILLDRIN ' UiFLORINt PHOTO- 0I Me THOATE ETHANE * I*It 1-TRICHLOROLTHYLENSt TETRACHLOROHcPTACHLOA I PD I50PH0 SPHAMIOE lindane NITROFEN PH6NF0RMIN .PICLORAM PROPANE, 1* 2-DIBRCM0-3-CHL0R0TETRACHLORDETHANE TRICHLOROETHYLENE JREA, l-BUTYL-3-(P-TOLYLSULFONYL)-` UREA, 1-I(P-CHLOROPHEN YL1SULFGNYL)-3-PROPYL-- 150-38-9 139-13-9 18662-53-8 18662-53-8 952-23-8 309-00-2 129-L5-7 133-06-2 133-90-4 57-74-9 143-50-0 67-66-3 80-08-0 62-73-7 60-57-1 60-57-1 13366-73-9 60-r5 1-5 71-55-6 127-18-4 76-44-8 3458-22-8 3778-73-2 58-B9-9 1836-75-5 114-86-3 1918-02-1. 96-12-8 79-34-5 79-01-6 64-77-7 94-20-2 FEED M R FEED M R FEED M R FEED ... M R FEED ' M R FEED M R FEED M R ... FEED M R FEED M R FEED R FEED M R .... GAV ' M R FEED M ft ...` FEED M ft FEED M R , i FEED ft FEED M ft .. FEED M R GAV M R. GAV MR FEED M R I P/I J M R IP/IJ . M ... R ... ..... FEED M R FEED . M . R - ... . FEED H R FEED . M . R .. _ GAV M ft GAV . M R .... GAV MR FEED . M R .. . FEED M i R PB270938-AS PB266L77-AS P B266177--AS PB266177-AS PB268553-AS P82 75666--AS PB277439-AS PB273475-AS P8273065--AS PB271977-AS PB 2 64041-AS P8264018-AS PB274394-AS P8270937--AS P8275666-AS PB275676-AS P8274393--AS PB264367-AS PB265082-AS PB272940-AS P827I967-AS P0277455-AS PB275677-AS PB273480--AS P82 77440--AS PB266176-AS P6276471--AS PB277472-AS PB277453--AS. P8264122-AS PB274483-AS PB275I78-AS CdEBIGALS-tfflyfiD-EBaiLIAfitf-lIA-SIlJLf-WSI-lSSUf.. i C 0 3261*) 01ARYLANILIDE YELLOW ui C0U4Y7 METHOXYCHLOR j '* I 6358-85-6 FEED 72-43-5 FEED '........ r M: R MR * NUFE THESE ARE THE ACCESSION CODE NUMBERS TO BE USED IN OBTAINING NCI TECHNICAL REPORTS FROM THE NATIONAL TECHNICAL INFORMATION SERVICE* US DEPARTMENT OF LABOR* 5285 PORT ROYAL RD. SPRINGFIELD VIRGINIA 22161 TEL: 1703) 557-4650 oAr.c A 1 see '1 9 7 0 TABLE I DATA AVAILABLE IB NO REPORT - DATA INSUFFICIENT NCI CHEMICAL NAME CAS # ROUTE SPECIES 0)4682 ACTINOMYCIN D C04726. ,AHABJNUSYLCYTOSINE C03474 AZATHIOPRINE C01592 ' If 4-BJTANEDIOL , DIMETHANESULFONATE C04808 CARBANILIDE, 4,4`-DIACETYL-BIS(AMI DI NOHYDRA ZONE ) j 01 METHANE Cu34d5 chlorambucil 0)4900 CYCLOPHOSPHAMIDE CU4o93 DAUNOMYCIN C04933 Of P1-ODD 00*667 D1BENZ0-P-DI0XIN 2,7-OICHLORG- C 036 7d DIBEN20-P-DI0XIN, I,2t3,4,6t7,8,9-OCTACHLQRO- CO 3656 DIBEN20-P-DI0XIN C04795 DIBRDMODULCITOL C047b2 DIBROMOMANNITOL,. COJ6B9 P-DIOXANE Cl>4dl9 3UANA20LE 00*054 HYOANTOiNr DICriLORODlMETHYL- 004739 :HYDRAZINEt 1-ACETYL-2-P1C0LINOYL- C0HB31 HYDROXYLUR'EA 004717 lMlDAZ0LE-4-CARB0XAMlDE-5-t3,3-DIMETHYL-1-TRIAZENO)- CO loi6 IMIDAZOLE MUSTARD L04o53 MfcLPHALAN C04d86 6-MERCAPT0PURINE C04944 MERPHALAN . C03190 METHANSULFON-M-ANISIDE t 4*-{9-ACRIDINYLAMINO)-, MONOHYDRO C04b71 MtTHOTREXATE C04875 McTHOTRCXATEf OICHLORO- ' 00*784 METHYLTHIOINOSINE C(J 4706 MI TO MYCIN C 004922 PHQS PHOP.ODI AMlQI C ACID, NN-BIS C 2-CHLOROETHYLJ-N 1 -3-HYDROXY 004897 PREDNISONE CUldlO PROCARBAZINE HYDROCHLORIDE CU3167 STREPTOZOTICIN 1. . 1` CU4d20 JkACIL MUSTARD 004773 UkEA * 1,3-BIS (CHLOROETHYL)-L-NITROSO- 004740 UkEAt l-(2-CHLOROETHYU-3-CYCLOHEXYL-l-NITROSO- CU4955 UREA, N-{2--CHLUROETHYL>-N-I4-METHYLCYCL0H6XYU-N-NITROSO- 004842 VINBLASTINE C04d64 VINCRISTINE 50-76-0 IP/ IJ M 147-94-4 IP/IJ M 446-86-6 IP/IJ M 55-98-1 IP/IJ M 15427-93-7 IP/IJ M 305-03-3 IP/IJ M 50-18-0 IP/ IJ M 1407-15-4 IP/IJ * M 53-19-0 IP/IJ M 33857-26-0 FEED M 3260-87-9 FEEO M 262-12-4 FEED M 10318-26-0 I P/I J M 488-41-5 .IP/IJ M 123-91-1 WATER M 503-88-8. IP/IJ M 118-52-5 FEED M 17433-31-7 IP/IJ M 127-07-1 IP/IJ M 4342-03-4 IP/IJ M 5034-77-5 IP/IJ M 140-82-3 IP/IJ ' M 50-44-2 IP/IJ H IP/IJ M IP/IJ M 59-05-2 IP/IJ M 528-7^-5 IP/IJ M 342-69-8 IP/IJ M 50-07-7 IP/IJ M i IP/IJ M 53-03-2 IP/IJ M 366-70-1 iIP/IJ M 18BB3-66-4 * IP/IJ M 66-75-1 IP/IJ M. 154-93-8 IP/IJ M 13010^47-4 IP/IJ M 865-21-4 57-22-7 IP/IJ M IP/IJ M IP/IJ . H R R R R R R R R R R R R R R R R R R R R R R R R R R R. R R R R. . R .. R . .. R R R R. R R. TauLc 11. BIOASSAY COMPLETE -- REPORTS HAVE BEEN DRAFTED. . 11A REPORTS BEING PRINTED NCI * CHEMICAL NAME CAS # ROUTE SPECIES CO 1536 ACRONYCINE C01707 ANILINE, 4,4 * --THIOOJCU2993 P-ANISIDINE, 2-METHYLC01730 ANTHRANlLIC ACID C01901 ANTHRAQUINUNE, 1-AMINO--2-METHYL- * Cu2o97 ASPIRIN, PHENACETIN AND CAFFEINE CO 1569 5-AZAC YTIDINE C00419 BENZENE, PENTACHLORONITRQC02664 BIPHENYL, CHLORO. CU0333 CHLOROPICRIN CU1558 CHOLESTEROL, (P-(BISC2-CHLOROETHYUAMINO)PHENYL) CO 1683 . DARAPRIM CO 15 81 BETA-OEQXYTHtOGUANOSINE C01989 2,4-DI.AMINOANISOLE SULFATE CO 1661 DIBENZYLINE HYDROCHLORIDE CO 3689 P-D10XANE C? 4.55 7 DIRECT BLACK 38 C54579 DIRECT BLUE 6 C54S68 DIRECT BROWN 95 COi605 EMETINE CUU5o6 endosulfan cO*,535 ETHANE, 1, l-DICHLOROC005L1 bTHANE, 1,2-DICHLOROC04604 ETHANc, HEXACHLOROCO4579 ETHANC, 1,1,2-TRICHLORO- CO 16 94 ETHIONAMIDE C02653 HEXACHLOROPHENE CO 1478 LASIOCARPINE C0U213 MALATH10N C04637 METHANE, TRICHLORUFLUORO- ACETATE 7008-42-6 IP/IJ M R 139-65-1 FEED M R 102-50-1 GAV M ft 118-92-3 FfcEO M R 82-28-0 FEED M ft 8003-03-0 FfetD M R 320-67-2 IP/IJ M R 82-68-8 FEED H R 27323-18-8 FEED R 76-06-2 GAV t M R 3546-10-9 GAV MR 58-14-0. FEED M R 789-61-7 IP/IJ M R 39156-41-7 FEED M R 63-92-3 IP/IJ M . R 123-91-1 WATER M R 1937-37-7 FEED M - R FEED M R 10300-74-0 FEEO M R . 483-18-1 IP/IJ M R 115-29-7 FEEO M t R 75-34-3 GAV MR 107-06-2 GAV . M . R . . 67-72-1 GAV M ft 79-00-5 GAV M .. R 536-33-4 FEED M R . 70-30-4 FEEO R 303-34-4 FEED R . 121-75-5 FEEO M . ft 75-69-4 GAV MR CdtBICdLS .flQYD-aOU-XifiLf_IIL.SIN-UI-I5SUE Ol C 30000 MENTHOL 89-78-1 FEED M R see -1 9 7 2 PAGE 03 TABLE II. BIOASSAY COMPLETE -- REPORTS HAVE BEEN ORAFTEO tlA REPORTS 8FING PRINTED ft Cl # CHEMICAL NAME C0195b CU3/92 CO 330 5 CU2233 LU1627 C03076 C017&5 L03&27 C00268 CU3u65 CJ4557 C0l6b5 CU0442 C037B1 CO3270 C31729 003247 C04524 003327 NAPHTHALENE) 1-NITROO-PHENYLENEOIAMINEi 4-CHLORO- M-PHEN YLENEOIAMINE.4-CHIQFG P-PHENYLENEOUMINEf N-PHENYI-, HYDROCHLORIDE 2,6-PIPCRAZ1NEDI0NE-4,4*-PROPYLENE d idxopipeaazINe PROPIONIC AC I 0 3-NITROPYRAZINECARBOXAM106 SUCCINIC ACID, MONO!2,2-DIMETHYLHYDRAZIOE)TETRACHL0KV1NPHDS TrilAZOLE r 2-AMIN0-5-NITR0THIOPHENE, Zt5-DIHY0R0-, 1,1-DIOXIDETOLUcNEt 2,4-DINlTRO- TRI PLURAL IN TRIMETHYL PHOSPHATE TKIS(2,3*-01 BRCMOPROPYL) PHOSPHATE TRYPTOPHAN. LUKEAt 1-1 (P-ACETYLPHENYL IS ULFONYL J-3-CYCLOHEXYLUREAi N, N* -OICYCLCJHEXYLTHI0UREA. 1--{HEXAHYORC- IK--A2EPIN-l--YL}--3-(P-T0LYLSULF0NYL)- CAS # ROUTE SPEC fS 86-57-7 95-83-0 5131-60-2 2198- 59,-6 504-88-1 98-96-4 1596-84-5 961-11-5 121-66-4 77-79-2 121-14-2 1582-09-8 512-56-1 26-72-7 73-22-3 968-81-0 1212-29-9 1156-19-0 FEED M R FEED M R FEED M R IP/IJ M R GAV M R FEEO M R FEEO M R FEEO M R FEED t . .M R GAV M R . FEED M R FEEO M ft ' FEED M R FEED M . R . FEED M R FEEO M . . R FEED H R FEED . M ft See ~197; cn > i W PAGE 04 REPORTS HAVE BEEN DRAFTED V) UJ _ cCcCcCCCcCcCcCcCcCcCcccCcCcCCCcCcCcCoCcCoicCcCcCcCcCcCcCcCcCcCcCcCcCcCcC o UJ o xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx UJ - f3- uOjD^jOujQujOaj>uQjaOjuOjuQjuQjOujQiuQujQtuCuljOuOjuOjuOjcOjuj>Ouj>u0ju0iu3j0uj0uj0uj0u0ju0jiu>>uQj O UJ ji .u Hi m <r m .11 liJ UJ !! illmuj lii in m .11 mm m <f ^ jj u. mtu ill m jj UJ ^ UJ a: u.u.u.iiu.oiLa.u.a.u.iij.u.itu.u-u.a.u.iLOu.ou-u.u.(j.u.u.u.u.ti<obtL a- in li r- m co m l( VJ N O < oo O o 4- *4 ^-i %o CM CO 04 cm a m m OOP- 4 j i 1 1 t 1 1 l 1 l l 1 I 1- I <3 *T m 4- O' cr* p- O' CO p O' o O 04 S*- O' o o cm o> in co --i p-- m in m H m 1 t 11 1 i i1 1 1l I|> i 03 p- 04 CO j* in O' CO O' f- o o ^ m CM CM o 4- m m JD O' m -- -- fM CO O' O' O' H r-i -- OJ 4- p* cn (A o CM M- cm -4 0-0 1t1 cm m in m tii cm m o m p <-h - m CO o CO O' -C*1 CM CM -4 CO 1i 1 1 t1 ii 1 r-* m M- m O' CM 4- o P- -4 m m cm m CC) -41 <M 11 t l 1 1 1 1 o p- CM CM m eo cm CM CM O' P- r-- m --c p- -4- r-- W 03 H fH H 4- 4- 11 eo CM O 11 43 ON " 43 I I I 1 J I I tIII II I II II tI I I l 2I t UJ I I i} PU>-J* IIt tx. i II I *Z- II tI I LT) | II Si I1 I I <UxJ I| iC i I UJ o --t oc 111 oa 1 _J M o X oc Od h- 1z oo o _j cC X Oo 1 > . X O1 to 4 Q| CC O 3- o X cc. o . >- ot xo f-- DC - p- z uj uj CC o1 --jo |1 _l -J V> X UJ UJ H* 1 *-- 1 OO a. --i - laC o>- XX z 1 - j-- M 1 4- Z 1 a: PC <t -- o o UI UJ Q o 1I _J 3 O 1 ecz.z cC 1f M cC a - >- _J --I o h- 1 P4 UJ - CP O' CC i t-- z cn *--i >_. XXXSCUJ4-XI- h u ut--p *r <r z 11 oo > a. a X z x- iuooh i - I z- 1 zz oa 1 < IU iuS*CtfZ'OON< 43 iu M H IU < a: cc , in 1o fC| _ O -- O o 1 - --1 V* _J --J UJ --.G>->-UMftO -3 V - O x x O UJ _J n < H- > UJ < a3 . CC 1-- -t UJ s UJ h*- UJ o cc i x x - <. ui --j X ui INI M oz ~ cn z o i-- _i <* l 1 u_ < X cn m _l _J h- 3 co o -- 3 1 < z UJ Z rr" J - UJ XJ UJ *o o iU O X 3 M UJ UJ ~7~ UJ Q UJ O IZZZ'Nm2UI X -4 ex UJ ^ <A m r X UJ -- X UJ _J O *-* +-* -- _l -- 2 t *4 J-- ct UJ Ui zo a3 zo O p-c X CM - HI JHQ 1-- o -j a. X X -OOO - --' X -< to C o 3jjoua n a Oj PC X o *-* < X --> o o UIUJhHhUJZOZ o --t M _J O D 03 O o o o JIJ- M -z o ex 3T 2 f- ZZiflV)V| J<4 X z > M PJ O -1 to a o Cl o+- -- Z O III < < < < UJ < _J n n: yaa-. UJ f- < < o X X UJ zr j t i U. < o P- < z z z *-- 1-- CJ & >- _J_JZZZ</>XXee 2 *4 tc 3 ra 3 O X o -- a X t cC cC < < UJ UJ UJ Uj --J M 2 1 CC si aC --1 -- o o n. a. Q. o o n o - X X X o o O 1 X _I Z Z J 1 1 Z Z 2 1 -vl UJ 1 < < X X 1 i < M Z 41 H UJ o <r 4 z o o o o -o ex Q L Q. O O CM UJ U 111 X f*f'SUMn.OHN'OJ-NiftJ30'ON-4-<C10H(DDN'JU,\,^^*>OifiO'tONN o O fl3 *" J. _! ^(j\ ^ h >. ?OM fOf'JJ'-'-C'O'J' O -I O O' 3 + <1^30 3300^ 3*<ON o oDoooooooc>3033oooOo..3 03oooooooooa Z O t_l J '_! _> *J O _> -J O O *-J J O >J O - J O O l_> tj O O O O O O U O O O O .J O -> m UoJ < a. BIOASSAY COMPLETE -- TABU II. see 5^1974 1 TABLfc 11. BIQASSAY COMPLETE -- REPORTS HAVE BEEN DRAFTEO . I IB REPORTS IN REVIEW NCI A CHEMICAL NAME coias>4 HYQRAZINE 1,2-DtPHENrLLU325B HYDP.OXYLAMINE, N-NITROSO-N-PHENYL-, CU456d METHANE TRIIGOO- C03010 METHYL ORANGE B C0J544 ML-XACARBATE CU302I 1,5-NAPHTHALENE0IAMINE CU0431 NICLOSAMIDE C02084 NITROUS ACID, SODIUM SALT C00226 PARATHION UU;>963 PHENUL4-AMINO-2-NITROC03316 P-PHENYLENEDIAMINE , 2-CHLOROC00:>8d PHOSPHAMIDiJN Cuiaio . 'PROCARBAZINE HYDROCHLORIDE CU 1672 PYRIDIUM C0U453 SULFALLATE C5UU22 SULFIS0NA20LE C01649 THIO TEPA C0424U TIT4NIUM DIOXIDE CU1U32 TOLUENE-2,5-OIAMINE, SULFATE CU1843 O-TOLUIOINE, 5-NITRO002153 P-TOLYLUREA C0U259 TDXAPHENE CU2119 UREA C03U05 UREAr (2-BR0MG-2-E THYL BUTYRYL)L02073 UREA, (P-6TH0XYPHENYU- AMMONIUM SALT CAS # ROUTE SPECIES 122-66-7 135-20-6 75-47-8 547-50-0 315-18r4 2243-62-1 1420-04-8 7632-00-0 56-38-2 119-34-6 6L5-66-7 13171-21-6 366-70-1 136-40-3 95-06-7 127-69-5 52-24-4 13463-67-7 6369-59-1 99-55-8 622-51-5 8001-35-2 57-13-6 77-65-6 150-69-6 FEED FF.ED GAV FEED FEED FEED FEED FEED FEED FEEO FEED FEED ip/i j FEED FEEO GAV IP/I J FEED . FEED FEEO FEED FEEO FEEO FEED FEED MR MR M. R MR MR MR MR MR MR MR M R MR MR M R. MR MR MR M .R MR MR MR MR MR H .. R . . MR see -1 9 7 5 PAGE 06 TABLe III. BIOASSAY HAS BEEN C_.iPLETED -- REPORTS ARE BEING ...AFT60 I'iL i # CHEMICAL NAME CU 3 ? 70 ' ACETANILIDE, 9-(CHLOROACETYL)C03349 ALt'TOHYDROXAMtC ACID, N-FL0UREN-2-YLCUdo40 ALOICARB CU2039 ANILINE, P-CHLOROCU2255 ANILINE, 2,4-01METHOXY-, HYDROCHLORIDE Cu 1990 ANILINE, 4,4'-METHYLENE8lS 1 N, N-> DI METHYL)C0d684 AwILIZIDfi C02006 BENZOPHENONE, . 9,9-BIS(DIMETHYLAMI NO)CU3t5U P-BENZOQUI NONE, DIOXIME CU3d61 5BETA-CH0L 4M-24-0IC ACID, 3ALPHA-HYDROXYCUB662 COUMAPHOS CU3667 DIBENZO-P-DIOXIN, 2,7-OICHLOROCU3656 D1BENZO-P-OIOXIN C02U2B DIBUTYLTIN DIACETATE C:>UX)35 DIMETHYL TEREPHTHAL ATE C02244 DIPHENYLAMINE, 9-NITR0S0- C5UU44 ETHER, BIS(2-CHLOPO-1-METHYLETHYLJ CIM651 FENTHION' L02175 ISOCYANld ACIO, 3,3*-DIMETHOXY-4,4'-8IPHENYLENE L03849 METHIQDAL SODIUM C03281 N-l-NAPHTHYLETHYLENEDIAMINE 01HYDROCHLQRIDE C03792 NITHIAZIDE C00420 NITROFEN 003932 NORPHENAZONE. LU4126 2-OXET AN JNE, 3,3-DIMETHYLC03930 P-PHENYLENEDIA MINE, 01 HYDROCHLORIDE Cu394l U-PHENYLENEDIAMINE, 9-NITRO002III P-PHeNYLENLDIAMINE, 2-NITROCU2013 PIPERONYL BJTOXIDE C02O24 PIPERONYL SULFOXIDE C03907 PYRIDINE, 2"(CHLUROMETHYL )-, HYOROCHLORIDE CU2200 STYRENE L02211 STYRENE, BETA-NlTRO-r CU2051 O-TOLUIDINF, 5-CHLORO002090 P-TOLUIOINb, 3-CHLOROC00260 TRIPHENYLTIN HYDROXIDE C03Blt> UREA, 1,3-DIETHYL-2-TH10C02017 UREA, 1-PHENYL-2-THI0CU2186 JKEA, 1,1,3-TRIMETHYL-2-TH10- ESTER ............ |. . CAS ROUTE SPECIES 190-99-0 FEED M R 53-95-2 FEED R 116-06-3 FEED M R 106-97-0 FEED M R FEEO M R 101-61-1 FEED M R 101-05-3 FEED M R 90-99-8 FEED M R 105-11-3 FEEO M R 939-13-9 GAV MR .56-72-4 FEED M R 33057-26-0. FEEO M R 262-12-4 FEED 4 ,.M R 1067-33-0 FEED M R 120-61-6 FEED M R 156-10-5 FEEO M R ' 108-60-1 GAV M '55-38-9 FEED M . R 91-93-0 FEEO ' M R 126-31-8 IP/I J M R . 1465-25-9 FEED M R 139-94-6 FEEO . H ft . 1836-75-5 FEEO M R 89-25-8 FEED . M . R .... 1955-45-9 GAV MR 624-18-0. FEED M . R .... 99-56-9 FEEO M R 5307-19-2 FEEO M R 51-03-6 FEED M R 120-62-7 FEEO M .. R GAV MR 100-42-5 GAV H .. R . 102-96-5 GAV MR 95-79-4 FEEO M .. ft . 95-79-9 FEEO M R 76-87-9 FEED H - - R 105-55-5 FEED H R 103-85-5 FEED - M - R ... 2489-77-2 FEED H R u I see 1976 PAGE 07 TABLE III. BIOASSAY HAS BEEN COMPLETED -- REPORTS ARE BEING UkAFTED r NCI 4 CHEMICAL NAME POSITIVE CONTROL CU0J84 ACUTAMIOE, N-FLUOR EN-2-YLLU1456 AFLATOXIN fii CU143* 1-BUTANOL i 4-tBUTYLNITROSAMINO)CO;i452. CARBON TETRACHLORIOE CU1467 CYCASIN C02700 DIPENTYLAMINE, N-NITROSO-. C0142J , GUANIDINEf 1-HETHYL-3-NITRO-1-NITROSOC,01409 LEAD ACETATE CUU362 SAFROLE C00373 S-TRI AZOLE 3-AMINOCO 1490 URACIL# 2-THI0- CAS 4 ROUTE SPECIES 53-96-3 1162-65-8 3817-11-6 56-23-5 14901-08-7 13256-06-9 70-25-7 301-04-2 94-59-7 61-82-5 141-90-2 FEEO FEED FEED GAV FEED FEED FEEO FEED FEED FEED FEED M R R M R R R R R 4 ,,M "R R R M R . see -1 9 7 7 (.n PAGE 08 TABLE IV. HI STQPATHOLCGY INCON. -ETE t NCI # CHEMICAL NAME CAS ROUTE SPECIES C01514 C02960 CU2<:99 C02926 cBOOll C02937 C03510 CUJ565 C0J598 C0U673 G03703 L 0 3 714 CU3690 CU2dB0 C02tt68. C02d57 CU2959 CU8695 C5U239 C02B91 000^15 L0o62B C5*604 C53B38 CbOl^ CU29U4 L02971 C0J612 Cu3b01 CU0U33 C50157 C50U33 C54S46 C02835 C53V07 C02302 C 023 68 CG2335 ADRIAMYCIN AMMONIUM, (2-CHLORQETHYUTRIMETHYL-, CHLORIDE ANILINE, 2,4,5-T RI METHYLAZOBENZENE BENZOIN CALCIUM CARBIMtOE CiNNAMYL ANTHRANILATE C.I. VAT YELLOW A P-CR6S0L, 2,6-Ul-TERT-BUTYLOIAZINON OI8EN20-P-DIOXIN, I,2,3,6,7,8-HEXACHLORGDIBENZO-P-DIOXIN, 2,3,7,8-TETRACHLORO-. DIBENZO-P-DIOXIN , 2,3,7-TRICHLOROUiPHENYLAMINE, N-NITROSQETHANE, I, l-OICHLORO-22-8IS IP-ETHYLPHENYL ) ** ETHYL TELLURAC ETHYL TUAOS FLUCMETURON HEXAMETHYLMELAMINE LfcDATE MALATHION MALATHION-U-ANALOG A,A1-MET HYLENED1ANILINE 2HCL OkANGE g PHENOL PHENOL, 2,4,6-Tft ICHLOROPHC1SPH0R0THI OIC ACID, 0,0-DIMETHYL 0-I P-NI TROPHENYL) PHTHALAMIDE PHTHALIC ANHYDRIDE 1,2-PRUPANEDIOL RESERPINE SELENIUM SULFIDE SELSUN SODIUM OIMETHYLDITHIOCARBAMATE SUN YELLOW FCF TOLUENE-2,4-DIAMINE O-TOLUIDINE, 4-CHLORO-, HYDROCHLORIDE O-TOLUIDINE HYDROCHLORIDE ESTER j. ... 23214-92-8 IP/IJ M R 999-81-5 FEED M R 137-17-7 FEED M R 103-33-3 FEED M R L19-53-9 FEED M R 156-62-7 FEED M R 87-29-6 FEED M R 128-66^5 FEED M . R . 128-37-0 FEED M R 333-41-5 FEED M R SP M .1746-01-6 SP M 33857-28-2 SP 4 , M 86-30-6 FEED " M .. R 72-56-0 FEEO M R 30145-38-1 FEED M R 14239-68-0 FEEO M R 2164-17-2 FEEO M . 645-05-6 IP/IJ M R 19010-66-3 FEEO M . ft 121-75-5 FEED M R 1634-78-2 FEEO M ft 101-77-9 FLED M R 1936-15-8 FEED R 108-95-2 WATER M 88-06-2 FEED M` . R . 298-00-0 FEEO M R 88-96-0 FEEO M . R... 85-44-9 FEEO M R 57-55-6 SP MR 50-55-5 FEED M R . 7488-56-4. GAV M ., R SP ' M 128-04-1 FEEO M . R 2783-94-0 FEEO R 95-80-7 (feed H R 3165-93-3 FEED H . R 636-21-5 .FEED M ... R . . CBaii:&L.a_tiQSD*SCH-IAflL^^IiU:_t^I-ISSUE - C50124 PHENOL 108-95-2 WATER R see -1 9 7 8 oac.f n9 TABLE V. BIOASSAY TESTING HAS .GUN BUT NO DATA ARE AVAlLABL. NS I CHEMICAL NAME C05732 C50475 C0db99 C5U464 C50613 C0o360 C50282 C 30635 -- C60602 05^3 75 C50646 C53849 CUy39 CU6B71 C537ol C50U5 C5i79<i C50657 C50260 C5I581 C54591 C54262 05*386 C52733 C5U668 C00522 CU4626 C5U384 C6ul35 C3U453 Ciu395 C5U 748 C54364 CU6B93 C5U419 C50362 C5U7J.5 CDV018 C50102 C50680 C06428 C0B902 AliROZINF 50 AGAR AGAR AGARITINE AlLYL ISOTHIOCYANATE AMINO UNDECANOIC ACID BENZYL CHLOklOc 2-BIPHENYLAMINE BISPHENOL A L #3-ttUTADIUNE BUTYL BEN2YL PH7HALATE CAPROLACTAM CARMJISINE gammA-chlcruane CHLORDANE, ALPHA ISOMER C* I DISPERSE YELLOW 3 CYCLOHEXANONE D AND C ,RED NO. 9 01AL tY'PHTHALAT er 1#4-DIAM If^iO-26-DICHLOROBENZENE CIS-1#2-DlCHLOROtTHYLENE TkAN$-U2-DICHL0R0cTHYLENE .1,1-OICHLOPOETHYLENE D1 12-ETHYLHEXYD AOIPATE 01 l 2-G TH YLHfc XYL) PHTHAL ATE 4# 41-DIPHENYL4ETHANE DIISOCYANATE ETHANE# 1,2-DIBROMa- ETHANE# 1,1,1-TAICHLOROETHYL ACRYLATE ETHYLENE CHLGRUHYURIN LUGENCL G'JAR GUM GUM ARABIC GUM TARA HtPTACHLOREPOXIDE LOCUST BEAN GUM MANNITOL MtLAMINE METHAPYR1LENE METHYLENE CHLORIOd' METHYL METHACRYLATE MlREX NITROFURANTOIN CAS If ROUTE SPECIES ........... 1 1' 57-14-7 INHAL M * 9002-18-0 FEED M R 2757-90-6 WATER M R 57-06-7 GAV MR 27323-47-3 FEED M R 100-44-7 IP/IJ M 90-41-5 FEED M R 80-05^7 FEEO M A L06-99-0 INHAL M R 85-68-7 FEEO M R 105-60-2 FEED M R 3567-69-9 FEED M 12789-03-6 FEED *..M R 5103-71-9 F.EEO M R 2832-40-8 FEED M R 108-94-1 WATER M R 5160-02-1 FEUD M R 131-17-9 . GAV . H . R FEED M R 156-59-2 GAV H .. R GAV MR 75-35-4 GAV MR 103-23-1 FEED. M R 117-81-7 FEED M R 101-60-8 GAV MR 106-93-4 INHAL . H . .R 71-55-6 GAV MR 140-88-5 GAV MA 107-07-3 SP M 97-53-0 FEED M R 9000-30-0 FEED M R 9000-01-5. FEED M . R. FEED R 1024-57-3 FEED M . R 9000-40-2 FEED M R 69-65-8 (FEED M R 108-78-1 FEED M R 91-80-5 iFEED . M . R. 75-09-2 GAV MR 80-62-6 INHAL M R. 2385-85-5 FEEO M R 67-20-9 FEED M . .R . see 1979 TABLL V. BIOASSAY TESTING HAS BEGUN BUT NO DATA ARE AVAILABLE 9 NCI i chemical namf C53830 C>U1 46 C53094 C50124 C55414 CSU077 L50099. C505BB COhUJ5 CU2722 C54V77 053929 L53907 C0J9B5 L52439 C50317 C5U533 LU*546 Ci>022b C 5 0442 GRANGE G 4* 4* -0 XYDIANILINE PENTACHLOROETHANE PHENOL PHENYLBUTAZONE PROPYLENE PROPYLENE OXIDE PROPYL GAL LATE RaNOOX STANNOUS CHLUR10E styrene OXIDE SUDAN 1 SUN YELLOW FCF TELONE 1,1,1, 2-TF.TRACHLOP.Q ETHANE TOLUENE-2,6-DIAMINE 01HYOROCHLORIOE TOLUENE 2i4"011SOCYANATE TRICHLOROETHYLENE ZtARAL ENJNE ZiRAH CAS ROUTE SPEC IES 1936-15-8 FEED H 101-30-4 FEED M R 76-01-7 GAV R 108-95-2 INHAL H WATER M R 115-07-1 INHAL M R 75-56-,9 INHAL M R 121-79-9 FEED M R 93-71-0 FEED M R 7772-99-8 FEED M R 96-09-3 GAV HR 842-07-9 FEED M R 2783-94-0 FEED v >.M 542-75-6 GAV " M R GAV R FEED ' M R 584-84-9 GAV MR 79-01-6 GAV M. 7645-23-0 FEED H R 137-3CH4 FEED. M . 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X 1 UJ OC Z O- o < a. _i z X X o o < CL i 1 UJ UJ Ul 30 H O IIJ J < UJ < 4- h- X o i-- O rg zo tii o O < uj o i gw a: _J --4 o o so xce.czxcCue>- z 43 > o < tu OC -- UJ -H 'JJ _j JOl-M Ni cC eg -- --< oo ZOO PH 3 O < t-- -J X Z 1-- O CM o as n rg X X o z < M M UJ Z z m i x x z o <Cu o u: a. a j j j m -1 < PH CO h* >- o < <-- M eo z o sc < ci O O O Uj UJ *-<<< UJ Z X rg (COO O X X O Z O Uj < cc z -- n UJ l/> CO in uj ot-z z < si eo OCSIX xi-ujdh 03 --J _J cCUUZ JhZ o o o Z Z o CO z 1 H A oild< >- CCUJOOO 3 0 0 0 CL 3 CO LC CL P4 X X OmmO'IJh --I _j 4 X CC UJ >* CO - O o O tfl H w o cC cc cc O' SC -J c< of c 3 x o a o <_> o _J O 3 X X >- O X o > > X a pu pg 1 Z uj x X X 1 331-00000X00 O 3 UJ < O 1 -- PH XI II-- 1-- t UJ ph X < >- H- u z z CM O O OlOtfl so <st j _I _ j _J o --l --1 -J o 1--0 0 z moo ij g rg ui uj o z X oo J X n JJ :y - n JC - I < X X X X X X X X 3 >- OJ UJ UL - i PH p P PH PH P o < <.<t --< < < < =3 eg z eo eo 33 -* rg 1-- o o o o o o cn o o o o 0 0 3 o mocLOeg-coooz --4 ai r-- O' eg -O eo O' m -4" tn o eg O' h- <e eg r- SO o g O 'u- n N e-n- so in -ogw g- m --< -4" --* tO 0 --i --* O' n| p. p- in O 1-- o pH O g -n n --i n g- UNO O o N O -4 so wNga n --* nn o O' O' g- *n o e g n o ig --4 o ^H N --j in --j .-n -- O -4 - 33 MJjwn -Mm P- rvr --i r-- O O' O' >- m --i --* 'N O' --* -- 4- a 4- o m J- m o 4- * O' n m o O' cn tn n in n g- gi g* -n cn in n o m o 4- o* g- 4- o n -n n o 4- 1 > n 4^ _n n in <n n o CJ n o n n n o n n in in -n n n n -n m n n in n n n o n m in n n n o n m z o o o j _> -J o o _> o o O j j j o o J OJ o JUJU -J o o o o _> _>00030U0 JO BCC 5-1981 286T-Q 33S r; ri r* r o r- p o c: o rv <*- o r o o o r- o p p. p. r p. pt p. p o p o o p p p r p p p. p p p. C w- c u U; c u c t vji u- c c C . vi o uiv. w w w o c w ^ o U' c u> u mviccoviu.v.v \r \r a'.iVi'\CuCUINN'\'J`CC^^^U.uJ J'J? icn-f-wu; c hco c n h c? o >-- --i a p-c u ru <o o c. r- ^ ~o cr c c >-- c *-- w-cp^ca^-^vi J*- ^ ^ Vif ^ S' ^ -P- ^ -P- ^ c fv> o- -*> r-- rv: o- o; tv> O ct oo vn i p^f\>o-4cr-4-P-4 WtfH^O^OOO't^U.^C'C.MO'NOOHiCNNWWftOffCOSU'UiO'UNHUiC'OONU > Dx xOi~Oc,O-->?trir2h2>^j2, (i yaSccSrij.tcN>2>Sr-- J>>no>m*-2-H^X-Hw^THJ<^<-2O?T5J2CrH^IiiOp pm-hl TI^ZOGOOhO Ol?o-<nt2MO "n o -- mcco"n*xocoi--i>or` -- o>cwwo.'nCcHr2>rr'3:r z > - n o 01 z m m x *--* hzkoijj ran > I oo C- X 73 < 73 Co c m r- oa o c 70 m >x <.> I-- 1-- cp -H la J> o > -- o *n it a 7J 75 T X 2. > -c r* r- o m *nrr. 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CHEMICALS THAT HAVE BEEN TENTATIVELY SELECTED FOR TeSTING: NL I CHEMICAL NAME C54933 PENTACHLCROPHENOL t54e37 PHTHALOCYANINE GREEN C55J01 PYRIDINE C5U339 RAUWGLFIA SERPENTINA C54739 P--ROSANI LINE C55210 RuTeNONE CdU566 SIMETHICONE C09165 SUDIUM ALUMINOSILICATE CsOi.91 SUOIUM DODcCYL SULFATE C&0204 SODIUM(2-ETHYLHEXYUALCOHOL SULFATE C55221 SUOIUM FLUORIDE C54S88 TETRAETHYL LEAD C55061 THPC L D 5050 THPS C54831 TRICHLORFON C0*546 TRICHLOROETHYLENE C54751 TRISI2-ETHYLHEXYL)PHOSPHATE C03327 JAEA, 1-(HeXAHYDRO-lH-A2EPIN-l-YL>-3 C50373 VINYLBRQMIDE C54999 VINYLC YCLOHL'XENG c5*uS9 VIOLET 3 C09132 WOLLASTONITE C652S2 XYLENES [ P-TQL YiSULFONYD- CAS # ROUTE SPECIES 07-86-5 1328-53-6 110-86-1 8063-17-0 569-61-9 83-79-4 8050-81-5 151-21-3 126-92-1 7681-49-4 78-00.-2 124-64-1 ti 52-68-6 79-01-6 78-42-2 1156-19-0' 593-60-2 GAV 1NHAL R. m' R* 1330-20-7 CatHlaLS_ADDQ_IQ-im:.Yl_SlNCE_L65I_lSSUE ISOPROTERENOL HCL PHEN0LEPHRIN6 HCL EPHEORINE CHLURPROMA 21NE ' EPINEPHRINE ERYTHROMYCIN ALPHA-MFTHYL BEN2YL ALCOHOL SUCCINIC ANHYORIDE CHLOROAMPHENICOL AMPHETAMINE BEN2YL ALCOHOL |. METHYL-DOPA Ln SUOIUM DICHLOROISOCYANURATE PENTAERITHRITOL TETRANITRATE CHLORINATEO TRISODlUM PHOSPHATE PAGE 14 see -1 9 8 3