Document GmdB4BZwxJQL47rQOq6gpzwDv

#R246 - 3320 52 H24768:OneGeneration Reproduction Study in Rats ARA4G - 3320 DuPont 13784 --~ : TRADE SECRET : Study Title F-24768: One-Generation Reproduction Study in Rats Volume 10f2 Laboratory Project ID: DuPont-13784 -- . | Auras: Eve Mylchreest, Ph.D. Joseph M. Lewis, B.A. STUDY COMPLETED ON: October 19, 2004 PERFORMING LABORATORIES: EL du Pont de Nemours and Company `HaskellTM Laboratory for Health and Environmental Sciences P.O. Box 50 Newark, Delaware 19714-0050 USA. EReLgLidounaPlonAntadleytNiecamloSuerrsviacneds C(oRAmSp)any DuPont Chemical Solutions Enterprise: Jackson Laboratory Route 130 Chambers Works Deepwater, New Jersey 08023 USA. o---- `SERVICE CODE NUMBER: () ~~ | -- Company Sanfized. Doe nol crniain TSCA EB meres $2476: OneGenerationReproduction Study in Rats DuPon-13784 `GOOD LABORATORY PRACTICE COMPLIANCE STATEMENT "This study was conducted in compliance with U.S. EPA TSCA (40 CFR part 792) Good Laboratory Practice Standards, whichare compatible with the OECD Principles of Good Laboratory Practice (as revised in 1997) published in ENV/MC/CHEM(98)17, OECD, Paris, 1998, and MAFF Japan Good Laboratory Practice Standards (11 NohSan Number 6283) except for the item documented below. The item listed does not impact the validity of the study. The bulk test substance characterization and stability analyses were performed at DuPont Regional Analytical Services (RAS), a non-GLP laboratory. These analyses were in compliance `with regulatory guidelines. None of the aforementioned analyses were performed under Good Laboratory Practice Standards; however, the analyses were conducted in compliance with 1509002 regulations. Allofthe analyses are considered valid and sufficient for the purposes of this study. Applicant/ Sponsor: EL duPontde Nemours and Company Wilmington, Delaware 19898 USA. -- Study Director: chreest, Ph.D. i Toxicologist 19-0c#- Woy Date Applicant / Sponsor: DuPont Representative Date Po -- -- Company Saniized. DoesnotcontainTSCA Cal 24768:One GenerationReproduction SudyinRas_* QUALITY ASSURANCE STATEMENT DuPont10784 `Work Request Number: 3 Study Code Number: "The conduct ofthis study has been subjected to periodic Quality Assurance inspections. The dates of inspection are indicated below. . Phase Audited Audit Dates Dates Reporte1d0 Study Director and Management Conduct: 6,11-Nov-2003; 11-Dec-2003; 12-Jan-2004; 3,6-Feb-2004 6,11-Nov-2003; 11-Dec-2003; 12-Jan-2004; 3,6-Feb-2004 Tables/Appendices: 13-14,16,19-23,26-Apr-2004; 7,8-Jun-2004 26-Apr-2004; 8-Jun-2004. ~~ Report/Records: 10-Feb-2004; 24,25-Mar-2004; 28-30-Jun-2004 12-Feb-2004; 25-Mar-2004 30-Jun-2004 Reported by: || - `Matthew Frentzel T= Quality Assurance Auditor 19. DeDtat-e2o0y TT -- -- Company Sanitized. Does not contain TSCA CBI HE2478: One Genrnion Repodction Sty nats. Duron18s ~~ CERTIFICATION `We, the undersigned, declare that this report provides an accurate evaluation of data obtained from this study. Atal Braun br: i eCC.VSuair Cahrm5oS ra _a1--lLeoette-zzooo0y. ronremaiedroutnoonrsroliCnE Rott Pin Frogs Diplomate A.C.V.P. psmfei2005 AsstEonvseciePaaiRnoelboogyny : LA -. 200 ~~ Do-oC.nMaennA, CD.oVV,g Date Approvedby: JRec sSoZ EMLaotrA sd ad Dito -- 19-Oct-zo0 Prepared by: Toan.ae Sees _19-05c: 00% iedbyStudy Director -- a `Toxicologist 19-aef=- wot eet CompanySanitized. Does not contain TSCA eR1 H-24768:OneGeneration Reproduction Study in Rats DuPont 13784 TAOFBCOL NTEE NTS Page GOOD LABORATORY PRACTICE COMPLIANCE STATEMENT crn2 QUALITY ASSURANCE STATEMENT ..c.ccsssssssssssnn3 CERTIFICATION ccm LI OFTSABLTES ccs LIST OFAPPENDICES cots STUDYINFORMATION ccs STUDY PERSONNEL cvs 10 SUMMARY crores INTRODUCTION. 13 OBIECTIVE .nsnssmmmammimsmsmmmmssspssmnmsassnd MATAE ND R METHIODSA...LS 3 JJ I ID. E. TAENSIEGSLPECHIUESSDc ANAY cr or i rm os s io on n 46 16 F.PretestandQUATANNNE PERO... |S G. H. CAlsisniigcanlmeOnbstetrovaGtrioounpssaannddMSOtTuadlyitStyarPty- RRANAGSOMv IZAUION c .r 1n 918 1 PyRats - BodyWeightsand Body WeightGAnS consis 19) J. Be BPy iRaotst- FtoiodaCognsiumnptminonaanmdmForodsEafTImCImENmCYmc mmsin ssssr innnirom019) L. ESUT0US Cele BVAIrGrrHON nll NM..LGAECSHIAHBOONNPPIOOCGRCAUUISIw ESo ..v .ce orrnrrrssssssss sssnsse nssscs22n00 O. ANGIOMIC PANOIORY.corrrrrssssssssssns21 DATAAFALYSES cvs RECORDS AND SAMPLE STORAGE css 25 RESULTS ANDDISCUSSION ccm 26 | REPRA.ODPyUCRaTtIs V- ECliTniOcXalIOCbOsLerOvGatYioc ns and MORality ..r ............. e mmmsndZ2]1 B. C. PPyyRRaattss -- FBoooddy CWoenisguhmtpstainodnaBnoddyFWOeOigEhFtfIGCaiienNsCYrsss sn 21 28 |-- D.EsA trousCycle Parameters in3 Py Fmales........ouwsmenwsssssmssnsissssssssrn:---28| -- i Company Sanitized. Doesnotcontain TSCA. cB H-24768:One-GenerationReproduction Study inRats DuPont 13784 ~ GF..RFeyprOoFdfuScptNivgeDTAOAXIc COIOBY CONo TUSIONS.c .. oon2299 ANATOMICAL PATHOLOGY rns 30 J B. Liver Weight Data - Py Ault RAS... ------|} 30 C. D. GMi0cr8osFcionpdiicnFgsin-dPiyngAsG-UPIyLARuISltc RAIS e e nr nns3300 FE ------| CONCLUSIONS rrr 38 APPENDICES coors T8 VOLUME 2mm sss 313 -- | --_ -- CompanySanilized.Doesnotcontain TSCA CY H-24768: OneGeneration Reproduction Sudy in Rats DuPont 13784 LI OFTSABLTES Page TABLE 1 SUMMARYOFCLINICAL OBSERVATIONSIN Py MALERATS. mmm--_0 TABLE 2 SUMMARY OF CLINICAL OBSERVATIONS IN P; FEMALE RATS DURING PREMATING......37 TABLE 3 SUMMARY OFCLINICAL OBSERVATIONS IN P,FEMALERATS DURING GESTAION. 38 TABLE 4 SUMMARY OFCLINICAL OBSERVATIONSIN P, FEMALERATS DURING LACTATION. .....39 TABLE 5MEAN BODYWEIGHTS OF P, MALE RATS... A TA6BMEALNBOEDYWEIGHT GAINSOF ByMALE RATS... AZ TABLE 7MEAN BODYWEIGHTSOF P; FEMALERATS DURINGPREMATING ccc bd TAB$MLEAEN BODYWEIGHT GAINS OF P,FEMALE RATS DURINGPREMATING a TABLE 9MEAN BODYWEIGHOTFPS; FEMALE RATS DURINGGESTATION... TABLE 10 MEAN BODYWEIGHTGAINS OFP; FEMALERATSDURINGGESTATION..... 9 TABLE 11MEAN BODYWEIGHTS OF P; FEMALERATS DURING LACTATION ccc S0 `TABLE 12 MEAN BODY WEIGHT GAINS OF P, FEMALE RATS DURING LACTATION st TABLE 13MEAN DAILYFOOD CONSUMPTIOFOPN;MALERATS DURING PREMATING....cvc:52 `TABLE14 MEAN DAILY FOOD EFFICIENCY OF P; MALE RATS DURING PREMATING. 54 "= TA15B MEALNDAE ILYFOODCONSUMPTOIFOPN,FEMALE RATS DURINGPREMATING v.56 TABLE 16MEAN DAILY FOOD EFFICIENCY OF Py FEMALE RATS DURING PREMATING. 5 TABLE 17MEAN DAILY FOOD CONSUMPTIONOF P; FEMALE RATS DURING GESTATION. .....60 TABLE 18 MEAN FOOD EFFICIENCY OF P; FEMALE RATS DURING GESTATION... 61 TAIBNLEPy19FMEEMAANLEESRTARTOSUS CYcCoLE PARAMETERSANsDe mPRE--COI--TAL--IN--TER--VAL 1 `TABLE20SUMMARYOFREPRODUCITNDIICVESE: Py GENERATION 63 `TABLE21 MEANPUPNUMABNDESURRVIVSAL: Fy GENERATION... sm `TABLE22 SUMMARYOF PUPCLINICAL OBSERVATIONS: Fy GENERATION vv 63 TABLE 23MEANPUPWEIGHTS: FyGENERATION cv nn TABLE24MEAN FINAL BODY AND ORGAN WEIGHTS FROMMALE RATS - Py ADULTS... 61 TABLE25 MEAN FINAL BODY AND ORGAN WEIGHTS FROM FEMALE RATS - Py ADULTS............68 | TABLE 26 INCIDENCES OF GROSS OBSERVATIONS IN MALE RATS - Py ADULTS. TABLE 27INCIDENCESOFGROSSOBSERVATIONSINFEMALE RATS Py ADULTS... TO TAIBNLEMA28LIENRCIADTESNC- ES AND LESION GRADES OF MICROSCOPIC OBSERVATIONS Py ADULTS. wm-------- mmmmdmm--ly ~~ TABILNEF2E9MIANLCEIRDAENTCSES- ANADDULLETSSI.O.N.GRADES OF MICsROSCmOPIsC OB--SER--VAT--ION-- S --"3% E-- e -----------: Company Sanitized. Does not contain TSCA CBI 24768: OneGenerationReproduction Sudy in Rats Dupont 13784 ~ LIST OF APPENDICES Page APPENDIX A CERTIFICATE OFANALYSIS.... sm-- mmmm---- APPENDIX BPROTOCOL AND PROTOCOLAMENDMENTS... 16 APPCEANANLYTDICAIL X DAT. -- e100 APPDIE NDIVNIDUADL CLIINIXCAL OBSERVAANDTMOIRTOALNITSY DATA.IN Py MALERATS.119 APPENDIEX INDIVIDUAL CLINICAL OBSERVATIONSIN P,FEMALERATS DURING PREMATING..128 APPENDIXFINDIVIDUAL CLINICAL OBSERVATIONSIN P; FEMALE RATS DURING GESTATION...138 APPIENNPD,IFXEGMIANLDEIRVAITDSUADLUCRLIINNGICLAALCTOABTSIEORNVATIOcNS rANDsMORTALITY DATA M8 APPENDIX H INDIVIDUAL BODY WEIGHTS OF P; MALE RATS AND MORTALITY DATA 158 APPENDIX IINDIVIDUAL BODYWEIGHTGAINS OF Py MALE RATS.. 168 APMPOERNTDAILXJIITNYDIDVAITDAU.A.L.BODY WEIGHTSOFrP,tFeEMALE RATS DUnRImNGmPReEMnATmINaG mANeD s--_ APPENDIX K INDIVIDUAL BODY WEIGHT GAINS OF P, FEMALE RATS DURING PREMATING.....185 APPLEINDNIVIDDUAILBOXDY WEIGHTS OF P;FEMALE RATSDURING GESTATION 198 APPENDIMX INDIVIDUAL BODY WEIGHT GAINSOFP, FEMALE RATS DURING GESTATION... 204 74 APPENINNDDIVIIDUAXL BODY WEIGHTS OF P, FEMALERATS DURING LACTATION... 210 APPEOINNDDIVIIDUAXL BODY WEIGHT GAINS OF P; FEMALE RATS DURING LACTATION.......216 APPENDIPX INDIVIDUAL FOOD CONSUMPTION BY P MALE RATS DURING PREVATING.......222 APPENDIQXINDIVIDUALFOOD CONSUMPTION BY P; FEMALE RATS DURING PREMATING ......232 APPERINNDDIVIIDUAXL FOOD CONSUMPTION BY P; FEMALE RATS DURING GESTATION ......242 | AP'PDEUNRIDNIGXPINDRIVIEDUAMLAANNADICMTOARLAEIBSITTRNAOTUISGOCNYCLE PAr RAMETERSINs P, FEMALE RATS 218 | APPPENRDITXEINMDAINVAIDDCUOTAHLAABINIITNAMTAILGOENS.T.R.OUS CYCLE STAe GESIN P; FEMALn ERATS DURING 254 | APPENDIX UINDIVIDUAL MATING DATAANDGESTATIONLENGTH: Py RATS ccc 260 | APPCENODRIPXORVLIUNTDEIAVICDOUUANLTSI:MPBLyARNATTATSI.O.N.SITE DATA, IMPLANTATION EFFICIENCY, mANDm---- | APP WINDE IVIDN UAL PDUPSUIRVIVXAL: Fy GENBRATIOcN cc m APPENDIX XINDIVIDUALLITTERCLINICAL OBSERVATIONS: Fi GENERATION voce 298 APPYEINDNIVIDDUAIL PXUP WEIGHTS: F, GENERATION... son | VOLIME Sms APPENDIX Z INDIVIDUALANIMALFINAL BODYAND ORGANWEIGHTSPiADULTS... 314 APPENDIXAA INDIVIDUALANIMAL PATHOLOGYDATAP; ADULTS ... 331 -- --- CompanySanitized.Doesnotcontain TSCA CBI STUDY INFORMATION 7 . | or Haskell Number: 24768 CAS Regis Norte (RNIN\ Composiion pf | KIaonui:(EU "| | Pica Crass {NNNY 1 Stability: The test substance appeared to be stable under the conditions of the study; no evidence of instability was observed. Sponsor: E. I. du Pont de Nemours and Company Wilmington, Delaware 19898 USA. Study nae Completed: Octobe 27,2003 (se report coves page) ~~ In-Life Initiated/Completed: October 30, 2003 / February 16, 2004 _ ef eeeebemmmemeeeeeeee Company Sanitized. Does not contain TSCA CE H-24768: One-Generation Reproduction Study in Rats DuPont 13784 ~~ STUDY PERSONNEL Study Director: Eve Mylchreest, Ph.D. Management: Jeannette M. Erhardt, Ph.D., C.LH. Study Author: Joseph M. Lewis, B.A. Primary Technician: GregorLy. Poindexter Management: Arthur J. O'Neill, B.S. Analytical Chemist: Janet C. Maslanka, B.S. Management: S. Mark Kennedy, Ph.D. Anatomic Pathologist: Steven R. Frame, D.V-M., Ph.D., Diplomate A.C.V.P. Peer Review Anatomic Pathologist: Management: Peter C. Mann, D.V.M., Diplomate A.C.V.P. Steven R. Frame, D.V.M., Ph.D. ToxicologyReportPreparation: MaryK. LaRoe Wanda F. Dinbokowitz. Management: Kim D. Birkmeyer, M.S. Laboratory Veterinarian: `Thomas W. Mayer, D.V.M., A.C.LAM. --_ Janice L. Connell, M.S., B.A., CLH. | --- eo | `CompanySanlized.DoesnotcontainTSCACBI CoMDanySaniied fiesi ieswe<t ~Rf H24768:OGneeneration Reproduction Sudy iRats DuPont. 13784 --_ SUMMARY p`Trheivsioonues-lgyecnoenrdauticotnedre9p0r-oddauyctsiuobnchsrtoundiycwtaosxiccoitnyduacntdeodnwei-tghenHe-r2at4i7o6n8raespraodfuocltlioown-usptutdoyawith the same test substance. The purpose of this study was to determine the repeatability of fertility and estrous cycle effects observed in the first study and to establish a no-observed-adverse effect level for reproductive parameters with this test substance. Throughout this study, Crl:CD(SD)IGS BR rats (24/sex/dose level) were dosed with H-24768 oanncdethdeaidloysbeyvgoalvuamgeewatasdo5semil/ekvge/ldsa0y,.1,Fo1l0,loorwi2n5g m7g2/kdga/ydsayo.f doTshiengve(hpircelmeatwiansg)d,etihoeniPzyed water generation males and females were cohoused within their respective treatment groups to produce F, litters. Dams were allowed to deliver and rear their offspring until postpartum day 4. Clinical observations, body weight, and food consumption in P: rats were recorded weekly throughout the study (food consumption was not measured during cohabitation nor thereafter for males). Estrous cycle parameters (percent days in diestrus, proestrus, and estrus) and estrous cycle length were evaluated for 3 weeks prior to and during cohabitation in Py rats. Filitterexaminations (pup viability, individual pup weights, clinical observations) were performed at birth and on lactation day 4. After litter production, all Py rats were given a gross pathological examination, the liver was ~ weighed, and the liver and reproductive organs saved for possible histopathological examination. Uterine implantation sites and ovarian corpora lutea were counted in Py female rats. Target organs (liver) and gross lesions from 10 randomly selected Py rats in the control and 25 mg/kg/day groups were examined microscopically. Reproductive organs from P: rats that did not produce offspring were examined microscopically. | `There were no effects considered to be related to H-24768 treatment on the following | parameters at any concentration: || Mortality and clinical observations in Py males and females | Body weight, weight gain and food consumption in Py males and females | Estrous cycle parameters in Py females | Mating, precoital interval, and fertility in Py males and females Gestation length, number of implantation sites, implantation efficiency, and number of | corpora lutea in Py females Number of pups (born, bom alive, alive on day 4), sex ratio, and survival indices during | the lactation period (day 0-4) in Fi liters ~ Clinical observations and body weights in Fy ltrs during lactation (days 0-4) [ -- Company Sanltized. Does not contain TSCA CB H-24768: One-Generaion Reproduction Sudy i Rats DuPont. 13784 --~ Gross lesions in Py rats Microscopic observations in the liver of Py rats Microscopic observations in the reproductive organs from P rats that did not produce offspring The only effect considered to be related to H-24768 treatment was an increase in liver weight in hPi,smtoalloegiacnaldcfheamnagleesrtatostdhoesleidvewriatnhd2w5amsgc/kogn/sdiadye.reTadhinsoenf-faedcvtewrasse pnhoytsaioclcoogmipcaalniaeddapbtyivgeross or response. aUnndderreptrhoedcuocntdiivteipoanrsaomefttehriss,stiundcyl,udtihnegnfoe-rotiblsietyr,vewda-sef2f5ecmtg/lekvge/ld(ayN,OtEhLe)hifgohresPty droaste, tFeistoefdf.spTrihneg, apparent increase in estrous cycle length and the decreased fertility reported in the first study are runelpirkoedluycttiovbeeptaersatmseutbesrtsanicse-1r0e0lamtge/dk.g/Tdhauys,,btahseeodveornalrledluocweesdtp-uopbsseurrvveidvaelffaencdt lweevieglh(tLdOuErLin)gfor lactation observed in the first study. The overall NOEL for reproductive parameters is 25 mg/kg/day, which is the same as the NOEL for subchronic toxicity observed in both studies. -- [|I Thhee NtesOt sLubfsotranhcse wsetrdeynostddeeftiencteedd.a Tthheush,igfhoersttidsossetuadty,whtihechNtOoExiLcaisloeqiucilvlayleinmtpo0rttahnetNfOfcEtLsaastidrebfuitnaebdlbeyto (thNeOUAnEitLe)dasStdaetfeisnEendvibryontmheenEtuarlopPreoatneUcntiioonnAg(1e9n9c4)y.(1985) and o th no-observed-adverse<fiec evel iz -- `Company Sanltized. Does not contain TSCA CBI HL24768:OneGeneration Reproduction Study in Rats DuPont 13784 . INTRODUCTION The test substance, H-24768, is at was tested previously in a combined 90- ddoasyesdubwcihtrho0n,ic25t,ox1i0c0i,tyoran5d00onmeg-/gkegne/rdaatyioHn-2re4p7r6o8duacntdiotnhesrteuwdya.s'noInntoh-eobpsreervvieodu-sefsfteucdty,lreavtesl were i(nNdOeExLi)n Pfyorartesprinodaulcltdiovseeegvraoluupast.ionEss.trTohuissccyocnlcelluesnigotnhwwaassbparsoeldonognerdeidnucPtyiaotnssiinn tahlledfeorsteility rgerloautpesd,ebfuftectthseotbosxeircvoeldogiincaPl,sriagtsnidfoiscaendcewiotfht5h0e0chmagn/gkeg/wdaasyuinncclleuadre.dOdtehcerremaedvnetrssein, bcoodmypowuenigdh-t parameters and food efficiency and reduced "related effects in 100 and/or 500 mg/kg/day number of implantation sites. groups included reductions in Adverse, compoundmean litter size, : number of pups bor and bon alive, pup survival during lactation, and pup weight at birth and during lactation. OBJECTIVE The purpose of this study was to determine the repeatabilityofthe fertility and estrous cycle effects and to establish a no-observed-effect level (NOEL) for reproductive toxicity of the test substance. Effects of the test substance on the gonadal function, conception, parturition of male and female Crl:CD(SD)IGS BR rats over one generation were evaluated. MATERIALS AND METHODS A. Sponsor And Test Facility `This study was sponsored by DuPont Chemical Solutions Enterprise (DCSE), E. 1. du Pontde Nemours and Company, Wilmington, Delaware and was conducted at DuPont Haskell Laboratory for Health and Environmental Sciences, E. I. du Pont de Nemours and Company, Newark, Delaware, and at Regional Analytical Services (RAS)at Jackson Laboratories (test substance stability), Deepwater, New Jersey. Sponsor approval of the study | was indicated by issuance of the Work Authorization Form. | Ee Bompany Sanitized. Does not contain Tara ma: H-24768: OneGenerationReproductionSudyinRats DuPont 13784 B. Study Design I. Experimental Design `Treatment Groups and Dail Group Number Pi Male Pi Female No/Group Daily Dosage (me/kg/day)* 10 0 2 0 (Control) mo v0 2% V-0 VEO 2% 1 10 (int(erLmoewd)iate) Vio VIL 2% 25 (High) = Weight of tet substance per kg of smal body weight at a dose volume of mL. Animals Adult Males Pregnant Females Nonpregnant Females Fy Pups Sacrifice Schedule Schedule After siring litters (Test Days 96-97) On day 4 of lactation `With pregnant females On da4y of lactation ~ 2. SelectionofDose Levels `The dose levels for this study were selected based on the results from the previous 90-day and t`hoenec-ugrerneenrtatsitoundyr,epwrhoedruect2i5onmgs/tukdgy/.d"ayDwoasseelxepveelcsteodf t1,o p10r,odauncde2e5ffmegct/skgo/ndfaeyrtwileirtyeasnedlelcitveedr for effects in the Py generation. The 1 and 10 mg/kg/day were expectedtorepresent cithear dose- response for fertility effects or the NOEL for reproductive toxicity. C. Analytical (Appendix C) 1 Vehicle The vehicle was deionized water. 2. Test Substance The test substance was supplied by the sponsor. The test substance was assigned Haskell Laboratory Number H-24768. This is the same batchoftest substance that was used in a previous 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations." "The stability of the test substance over the course of the study was confirmed by physical ~ property analyses conducted near the beginning and end of the study by the DuPont Regional Analytical Services (RAS) (Appendix C). -- Tw --_ [CompanySanitized. Doesnot contain TSCA CB" 24768: OneGeneration Reproduction Study in Rats Dupont 13784 --~ 3. Preparation, Administration, and Analysis of Test Formulations a. Test Formulation Preparation Fstoorrmeudlaattiroonosmoftetmhpeetreasttusruebsunttainlceuseidn.thOenvceheicrelfer(idgeeriaotneidzesdtowraatgeers)tawbeirlietyprweapsareesdtadbaliilsyheadnd (mAipxpienngdtihxe Ct)es,tfsourbmsutlaantcieonwsitwhertheepvreehpiacrleedwtawsicdeoacuwmeeenkteadndinsttohreesdtruedfyrirgeecraotredds.. The method of b. Test Formulation Administration "The test substance was administeredorallyasi s a potential route for human exposure. The test substance was administered by gavage once daly. Dosing Schedule Al animals were dosed daily by gavage for approximately 70 days prior to cohabitation and during the cohabitation period (up to 2 weeks). Py male rats and Py female rats showing no evidence of copulation continued to be dosed aftr the end of the cohabitation period until sacrifice. + Females showing evidence of copulation were dosed throughout gestation. + Pregnant females in the process of delivery or showing signs of delivery were not dosed. 5 Females were dosed after delivering litters, through lactation, up to sacrifice. Females that did not delivear litter continued to be dosed until sacrifice. Test Formulation Sampling `Samplesofcach test formulation (approximately 3 mL) were taken 3 times during the study. `Analyses addressed concentration, uniformity of mixing, and 5-hour room temperature stability. SGarmopulpeast wHeasrkeelslu,bmeixtcteepdtsfhoorrsttlaybialfitteyr steasmtpfloersmuslwahtiiocnhpwreerpearsautbimointttoedthaeftAenralbyetiincgalstCohreemdistry refrigerated for 7 days, If samples could not be analyzed at the specified times, they were frozen until analyses could be | croonodmuctteemdp.erOatnurdeayfsorspaomspsliebsleweadrdeittiaokneanl,atnhaelyfsoirsm.ulations remaining after dosing were stored at 4 Test Formulation Analysis | (Appendix C) | `The analytical method used is described in Appendix C. Results from the analysisof the test formulation samples indicated tha the test substance was uniformly mixed, at the expected | concentrations, and stable in the vehicle for 5 hoursaroom temperature at all dose levels. |- g -- | Company Sanitized. Does not contain 7524 rn" H24768: OneGenerationReproduction Study in Rats DuPont 13784 --_ D. Test Species The rat was selected for this study as itis a preferred species for reproductive toxicity testing as recommended by the regulator extensive background data are y guidelin available es. fr omThteheClrilte:rCatDure(,StDh)eIsGuSppBliRers,t rain and wpraesvicohuossesntubdeiecsause wsuiitthabolteherrelcaotimvpeotuonldosngaetviDtuyP,ohnatrdHianesskse,llanLdabionrcaitdoernyc.e Tohfisspospnetcaineesouasnddissteraasiensa.re also considered OdanteOocftoAbuegrus1t6,2220,0230,0130w8emraelreeacenidve1d09frfoemmaClhearClrels:RCiDve(rSLDa)bIoGraStoBrRiesra,tsI,ncw.i,tRhalaenigahs,siNgonretdhbirth Caaprporloixniamaftoerluyse13o8n.2t-hi1s83s.t3udgyr.aTmhse(mraatlsesw)eraendapapprporxoixmiamtaetleyly5512d6a.y0s-1o5l8d.a7ngdrwaemisg(hfeedmales) at arrival. Male and female rats were nonsiblings. `The rats were approximately 69 246.7-318.0 grams (males) and d1a7y9s.0o-l2d35a.t5thgerastmasrt(offemtarleeast)m.ent, and in the body weight ranges E. Animal Husbandry I. Identification a Pretest ~ Priorto assignment to groups, each rat was assigned atemporary cage identification. b. After Assignment to Treatment Groups A unique number was assigned to each rat and an identification number wastattooedon their tail and recorded on the cage card. 2. Housing All male rats were housed individually during non-mating periods in stainless steel, wire-mesh cages suspended above cageboards. a Pretest and Premating All rats were housed individually in stainless steel, wire-mesh cages suspended above cageboards. b. Cohabitation Period All rats were housed as breeding pairs in stainless steel, wire-mesh cages suspended above cageboard. At the endofthe cohabitation period, females without evidence of copulation were housed individually in polycarbonate pans | -- EE ---- Company Sanitized. DoesnotcontainTSCACBY H-24768: One-Generation Reproduction Study in Rats DuPont 13784 ~ Gestation Period (Females with evidenceofcopulation) Days 0-20: Dams were housed individually in stainless steel, wire-mesh cages suspended above cageboards. Day 20-Delivery: Females were housed individually in polycarbonate pans with bedding. 4 Lactation Period Dams were housed with their litters in polycarbonate pans with bedding. 3. Environmental Conditions ~ Animal Rooms a Temperawre Animal rooms were maintained at an acceptable temperature of 18-26C (targeted at 22:24C). b. Humidity Animal rooms were maintained at an acceptable relative humidity of 30%-70% (targeted at 40%60%). c Lighting ~~ Animal rooms were artificially illuminated (fluorescent light) on a 12-hour light/dark cycle: (approximately 0600-1800 hours). `Occasional excursions outside the accepted ranges were minor and did not affect the study. 4. Feedand Water a Feed All rats were fed pelleted PMI Nutrition International, Certified Rodent LabDiet 5002 ad libitum. bo Water Tap water from United Water Delaware was provided ad libitum. || | |~ Bd -- | CompanySanitized.Doesnotcontain TSCACBI H-24768:One.Generation Reproduction Study in Rats DuPont-13784 ~~ 5. Health Monitoring Program As specified in the Haskell Laboratory animal health and environmental monitoring program, the. following procedures are performed periodically to ensure that contaminant levels are below those that would be expected to impact the scientific integrity of the study: + Water samples are analyzed for total bacterial counts, and the presence of coliforms, lead, `and other contaminants. + Samples from freshly washed cages and cage racks are analyzed to ensure adequate sanitation by the cagewashers. Certified animal feed is used, guaranteed by the manufacturer to meet specified nutritional requirements and not to exceed stated maximum doses of key contaminants, including specified heavy metals, aflatoxin, chlorinated hydrocarbons, and organophosphates. The presence of these contaminants below the maximum dose stated by the manufacturer would notbeexpected to impact the integrity of the study. `The animal health and environmental monitoring program is administered by the attending laboratory animal veterinarian. Evaluation of these data did not indicate any conditions that affected the validity of the study. ~~ F. Pretest and Quarantine Period Upon arrival at Haskell Laboratory, the rats were quarantined for at least 6days. The rats were observed daily for any clinically apparent signs of disease or injury and weighed 3 times. One rat that died during the pretest period was necropsied to check for the presence of disease; none was evident. On the basis of acceptable body weight gains and clinical observations, all surviving rats were released from quarantine on test day 8 by the laboratory animal veterinarian or designee. G. Assignment to Groups and Study Start - Randomization Rats of each sex were ranked by their most recently recorded body weight and randomly assigned to control and experimental groups. The randomization resulted in a distribution in which the `mean body weights for all groups within asex were not statistically different (p > 0.05). Rats not assigned to a test group, a the discretionofthe study director were released for use in other studies, or were sacrificed by carbon dioxide euthanasia and discarded without pathological evaluation. 0 -- `Company Sanitized. Doosnotcontain TSCA CBI H-24768: OneGeneration Reproduction Study inRats DuPont. 13784 ~~ H. Clinical Observations and Mortalit--y Py Rats Clinical observations were performed at least once weekly throughout the premating, gestation, aabnndolramcataltiboenhapveriioordas.nd/Eoarchaoppfetahreanacdeu.ltMroarttsalwiatsy,inmdoirviibduunadliltyyh,apnedrlteidneanntdbechaarvefiuolrlaylecxhaamngiense,d for signs of difficult or prolonged parturition, and all signs of overt toxicity were recorded. `Cage-side examinations were conducted twice daily throughout the study. Mortality, s`miogrnisboufndoivteyr,tpteorxtiicnietnytabtethhaevicoargael-scihdaengeexsa,misniagtnisoonfwdeifrfeicrueltcoorrdperdoblyonegxecdepptairtounri(tiico.n,thaendnealwl clinical sign was recorded and previous clinical signs were verified and, if present, recorded). 1 Py Rats - Body Weights and Body Weight Gains 1. Premating Period AIP rats were weighed once a week. 2. Gestation and Lactation Periods P, females were weighed on days 0,7, 14,and21 of gestation. Py females were weighed on days 0 an4d of lactation. Females without evidence of copulation, those that copulated and did not delivear litter, and males were weighed on a weekly schedule. J. Py Rats - Food Consumption and Food Efficiency Each feeder was weighed at the beginning and end of the weekly food consumption interval and the final weight of the feeder and the amount of spillage from the feeder during the interval was subtracted from the initial feeder weight. From the food consumption and body weight data, the mean daily food efficiency was calculated. 1. Premating and Cohabitation Periods Individual food consumption was determined weekly throughout the period, ending test day 71. Food consumption was not determined during cohabitation. i 2. Gestation and Lactation Periods | Individual food consumption of pregnant Py females was recorded on gestation days 0,7, 14, and | 21, and for lactating females on lactation days 0 and 4. Food consumption was not measured for females without evidence of copulation, females that did not deliver a litter, or for males. | Although food consumption data were collected during lactation, evaluation of these data | --~ pinrdeisceantteeddtihnatthiitswraesponrottbnuetcaersesairnycltuodmedeeitn the the objective of this study records. study, thus the data are not 0 Company Sanltized. Does not contain TSCA CBI H-24768:One-Generation Reproduction Study in Rats DuPont 13784 ~ K. Breeding 1. Cohousing Each female was continually housed on a 1:1 basis with arandomly selected, nonsibling male of the same dosage level, in the male's cage. On the day copulation was confirmed, the female was transferred back to individual cage housing. 2. Startof Cohabitation Animals were cohoused after 72 days (approximately 10 weeks)ofexposure to the test substance.Theday animals were first cohoused was designated as day 1 of cohabitation. 3. Duration of Cohabitation Period Animals were cohoused unil evidenceofcopulation was observed or until 2 weeks had elapsed. The cohabitation period ended in the morning of day 15 of cohabitation. 4. Evidence of Copulation Once daily, each female was examinedforan intravaginal copulation plug or sperm in the. vaginal lavage sample, either of which was considered evidenceof copulation. The day evidence of copulation was observed was designated as day 0 of gestation. L. Estrous Cycle Evaluation Vaginal lavage sampleswerecollected daily from all Py female rats in order to determine the stagesofthe estrous cycle. Vaginal lavage samples were collected beginnin3g weeks prior to `mating, and continuing until copulation was confirmed, or the cohabitation period ended. The vaginal lavage sample collected on the day copulation was confirmed was not used for estrous cycle evaluation. Vaginal lavage samples were examined microscopically for determination of the stage of the estrous cycle (diestrus, estrus, proestrus). | M. Gestation Procedures | After being transferred into polycarbonate pans (on day 20 of gestation for mated females, or at the end of the cohabitation period for females without evidenceofcopulation), female rats were | observed at least twice daily for signsof delivery and offspring. | N. Lactation Procedures | `The day when delivery was complete was designated da0y postpartum. At each examination | period (days 0 and 4 postpartum), offspring were individually handled and examined for | abnormal behavior and appearance; any dead or abnormal pups were recorded. EE -- `Company Sanitized. Doss not contain TSA CBI HL24768:OneGeneration Reproduction Sudy in Rats DuPont 13784 --~ 1. Day0Postpartum Live and dead pups in each litter were countedbysex as soon as possible after delivery was completed. Live pups in each litter were individually weighed. 2. Day4 Postpartum Live pups in cach liter were counted by sex and individually weighed. All pups were euthanized (by decapitation) and discarded without pathological examination. . Anatomic Pathology Lo PiAdults a. Enthanasia and Postmortem Examinations All Py parental generation rats were subjected to a gross pathological examination, including those for which mating did not result in production of offspring. The uteri of all cohabited females were examined for the presence and number of implantation sites and corpora lutea counts were recorded. All gross lesions were preserved in appropriate fixative for possible future histopathological examination The following tissues and all gross lesions were collected from all Py adults sacrificed by design. ~ All collected tissues were preserved in appropriate fixative for possible future histopathological examination. Organ Weights from P; Adults T BothSexs Liver Tissues Collected from P; Adults Sacrificed by Design Male Female BothSexes Testes Ovaries (with oviducts) Gross Observations" Epididymides* Uterus Liver Prostate Vagina `Seminal Vesicles Cervix _4_TChoesgriughltattesitnisgaGnldaenpdidsidymis was placed in Bouin's solution. 000000000000 The lef testis and epididymis was frozen for mpoaslseibalnedsfpeemramlecoautnstweevarleuaptliaocnes.d iAlfloormtahlrin.tissues (reproductive andpeoproductve) collected from wGreorsesgelneseiroanlslyobnsoercvoeldleacttendecropsy for which histopathology vas not appropriate or would not be additive Histopathological examination of the liver was conducted for the first 10 parental rats (the first 10 consecutive animal numbers in each group) surviving to scheduled sacrifice in the Py male: -- and female high-dose and control groups. The liver was examined for one additional male rat in the Py control group because a gross lesion was observed at necropsy. -- `Ca ompany Saritized. Doss no contin TSCA CB -- H-24768:OneGeneration Reproduction Study in Rats DuPont 13784 --_ There were 12 adult pairs with impaired reproductive performance (e.g. failure to mate, ecvoanlcueaitveed,. siTreh,eourtdeerluisvewrahseealxtahmyionfefdspfrionrgo).neTahddeitrieopnraoldufcetmiavleeorragtainnstohfe tPhyecsoenrtartoslwgerroeup becausae gross lesion was observed at necropsy. In addition, most gross lesions were evaluated `microscopically. `Sperm count determination was not performed since it was not considered necessary to meet the objective of this study; tissues were discarded. 2. Offspring Offspring that were found dead during the lactation period underwent an external examination and were discarded. | || - m -- Lompany Sanitized. Doesnot contain TSCA CBI 24768: OneGeneration Reproduction Study in Rats DuPont13784 DATA ANALYSES Tadhueltsf.ollowing table lists the indices of reproductive function that were calculated for the Py Reproductive Function Calculations `Mating Index (%) = Number Copulated" Number Cohabited x 100 Fertility Index (%) = NumberPregnant' x100 `Number Copulated" NumberofLitters with Gestation Index (%) = aNtuLmebaestr OofnLeiLtievres Pup x 100 Implantation Efficiency (%) = N NumubermooffIb Pmupple saBntor amtion Stes x100 Pups Bom Alive (%) = NNuummbbeerrooffPPuuyps Bom x100 ~~ Viability Index (9 = Numberof Pups Alive Day 4 Preculling x 100 `Number of pups bom alive. Bfvoiudnedndceoaodfpcroepgunlaanttioonr=demlaivveargyionfaallctoepu.latory plug. sperm in vaginal ava, InTcolubdeidngetiheomsienfeofunodcdaachdiptree.gnaMnetadnuarinndgsgtesatnadtairond.devition for each dose vel willbe calculated. & Excluding liters sacrificed duefodeathof damdurin lactation. | | e CREE t PB Company Sanitized. Does not contain Tsca = H24768: OneGeneration Reproduction Study in Rats DuPont 13784 ~~ StatisticalMethods Parameter Preliminary Test significant nificant BBooddyy WWeeiigghhtt Gain FFoooodd CEfofniscuimenpctyion Gestation Length OrImgpalanntWaetiigonhtSite Numbers ICmoprlpaonrtaatLiuotneEaffCiocuinetnscy MPeeracennNtuBmobmerAolfiPveups Per Litter 0Pr4ecDoafyalVIinatbeirlviatly Estrous Cycle Parameters Levene'sest .for iy Sthapoimroo-gWielkneesiatnydf| or | VOane-wrayiaaannndycDusene"osf | normality" ec"iungdaDnutnn-'wsatsetse"s iMnactiidnegncIenodfexClinical Observations None CochranArmitage es or rend Fertility Index Sex Ratio (Covariat: liter size) Tevengecn'esiteysat faonrd | Analysisofcovariance | Non-parametric analysis _ Me(aCnovParuipstWee:iglhittesr size) Sapiro: ay for | aand Dummer Hsat Heat `ShhaepirSohWapiirko eWsltkwaestsiwgnsifincoatnts,iKgeiufiscknatl-bWuatlLsevesetnweastesftowllaoswiegdiwfiitchanDtu,nn'rsobeuss.t version of Dunne' st was used. Ifthe b eAnormmslwiazisnsigg,nvifairciaanntcenosnt-bmionloitnognitcriatnysfoinrmtathiodnoswea-sreusspeodnases,nteehdeeFdi.shersexact es was ued with Bonferon conection. For each parameter analyzed with a trend test, the test was applied to the data sequentially. If a significant dose-response was detected, data from the top dose group were excluded and the test repeated until no significant trend was detected." For litter parameters, the proportion of affected pups er lite orth liter mean was used as the experimental unt for statistical evaluation.' The level of significance selected was p < 0.05. Additional statistical tests were used, and other parameters analyzed,ifdeemed necessary. -- 2% -- Company Sanitized. Does not contain TSCA CBI H-24766: One-Generation Reproduction Study in Rats DuPont 13784 RECORDS AND SAMPLE STORAGE Laboratory-specificorsite-specific raw data, such as personnel files and equipment records will obreigrientaalinreedcobrydtsh(esfpaocnisloitry-swuhpeprleitehdechwaorarcktewraiszadtoionne.ofAtlhleotreisgtinsaulbsrteacnocred)s, owriltlrbuecroeptiaeisneodfat `DuPont Haskell Laboratory, E.L du Pont de Nemours and Company, Newark, Delaware or at Tron Mountain Records Management, 200 Todds Lane, Wilmington, Delaware. A sample of the test substance was collected for archive purposes and retained at DuPont Haskell Laboratory. Specimens (if applicable), raw data, and the final report will be retained at DuPont Haskell Laboratory, Newark, Delaware, or at Iron Mountain Records Management, Wilmington, Delaware. 5 -- Company Sanitized. Doesnot contain TSCA CBI H24768:One Generation Reproduction StudyinRats DoPonel37sd py | | | --~ { _-- RESULTS AND DISCUSSION `Company Sanitized. Doesnotcontin TSCA CAI H-24768: One-Generation Reproduction Study in Rats DuPont13784 REPRODUCTIVE TOXICOLOGY A. Py Rats- Clinical Observations and Mortality 1 PyMales: (Table 1, Appendix D) There was no test substance-related mortality during the study (refer to Anatomic Pathology, Section A, for more details). There were no test substance-related clinical observations at any dose level. 2. Py Females: (Tables 2-4, Appendices E-G) There was no test substance-related mortality during the study (refer to Anatomic Pathology, Section A, for more details). There were no test substance-related clinical observations during premating, gestation, or lactation at any dose level. B. Py Rats - Body Weights and Body Weight Gains Lo Pi Males: ~ (Tables 5-6, Appendices HD) There were no test substance related effects on body weights and body weight gains at any dose level. Occasional findings of statistically significant increases or decreases in weekly body weight gain (days 28-36 and 85-92 at 25 and 10 mg/kg/day, respectively) were considered spurious due to their sporadic nature, lack of dose-response relationship, and/or lackofeffect on final body weight or overall body weight gain. 2. P Females: (Tables 7-12, Appendices J-0) There were no test substance-elated effects on body weights and body weight gains during `premating, gestation, or lactation at any dose level. Occasional findingsof statistically significant increases or decreases in weekly body weight gain (days 1-8 and 43-50 at 25 and 10 mg/kg/day, respectively) were considered spurious due to their sporadic nature, lack of doseresponse relationship, and/or lack of effect on final body weight or overall body weight gain. 7 -- `Company Sanitized. Doesnot contain TSCA CBY H-24768: OneGeneration Reproduction Study in Rats DuPon-13784 C. Py Rats - Food Consumption and Food Efficiency IP(TaMballeess1:3-14, Appendix P) Tdhureirnegwperreemantointegstatsuabnsytadnocsee-rleelvaelt.edTehffeecrtesduocnefdofoodocdoenfsfuimcipetnicoynoonrdfaoyosd2e8f-f3i6ciwenacsy cionnPsiismteanltes with the reduced weight gain during this weekly interval and was considered spurious. 2. Py Females: (Tables 15-18, Appendices Q-R) Tfheemarleewsedruerinnogtperstemsautbisntga,ncoer-rgeelsattaetdioenffaetctasnyondofsoeodlecveoln.suOmcpctaisoinonoarlffoionddienfgfsicoifesntcaytiisntiPcyally fsiogondifeifcfainctiiennccyre(adsaeysso2r2d-e2c8reaansdes50i-n5w6eeatkl1y0 fmogo/dkgc/odnasyu)mpwteiroenc(odnasyisde1r5e-d2s2pautri2o5usmgd/ukeg/todatyh)eiorr cspoonrsaudmipctniaotnuroer, floaocdk oefffdiocsieen-crye.sTpohnesestraetilsattiicoanlslhyispi,gannifdi/coarntlacchkaonfgeefsfeinctwoeenkolvyerfaololdfeofofdiciency on dwaeyisgh1t-8gaainndd4u3r-in5g0tahte2s5e waenedk1l0ymign/tekrgv/adlasya,nrdewspeerceticvoenlsy,idweerreed csopnusriisotuesnt with the changes in D. Estrous Cycle Parameters in Py Females (Table 19, Appendices S-T) Tprhoeersetrwues,reornometaesnt esusbtsrtoaunsccey-crleelalteendgtehffaetctasnyondotshee mleevealn. peArscesnhtodwanysinintheesttraubsl,edbieelstorwu,s,thoermean lengthofthe which mean estrous estrous cycle cycle was similar length at all across groups. dose levels was This differs higher than finrotmhetchoenptrreolvigoruosups.tuTdyh,e" in `dipfafrearmientgerressiunlctes vfoarlueesstrionubsoctyhclsetuldeinegstwhecraenwbietheiansitlhyeattetsrtiibnugtalbalbeotroatnoorrym'salhivsatroiraibciallitcyonitnrothlis range (4.14.9; 14 studies from 1999-2003) and the apparent dose-related trend was in opposite: directions in the 2 studies. Reproductive Toxicology Text Table 1. Estrous Cycle Parameters in Py Females Report StuNduymbers, 0 1 Do1s0e (mg/kg/2d5ay) 100 500 a3 47 5 4s 44 aa17 a-9 a-s E. Reproductive Indices in Py Rats (Tables 19-20, Appendices S-V) Tfehretirleitwy,egreestnaotitoenstlseunbgstht,anncue-mrbeelratoefdiemfpfelcatnstaotniotnhesilteensg,tihmpolfatnhteatpiroecnoeiftfailciienntecryv,alo,rmnautmibneg,r of ~~ corpora lutea at any dose level. As shown in the table below, the fertility index was similar EF | Company Sanltized. Does not contain TSCA CBI HL24768: One-Generaion Reproduction Study in Rats DuPont 13784 across groups. This differs from the previous study", in which the fertility index at all dose ~~ lsetvuedlysawraesoultoswiedre tthhaenteisnttihneg claobnotrraotlogrryo'usp.hisAtolrtihcaolugcohntferrotlilritayngined(ic7e2s%o-f15005%%;-6150%stiunditehse ffirrostm t1h9e99fi-r2s0t0s3t)u,dyitiwasliskiemliyltaorhaatvaellbdeoesneilnecviedlesntaanldftohrust,hewfaosllnoowtidnogser-eraesloantse:d;12))tthheelreowwefreretinliotyotinher caonrorvoubloartaitoin,vehfyipnodsipnegrsmoifa,reapsrpoedrumcitai)veintotxhieciftiryst(hsitsutdoypatthhaotlwogoiucladl bcheapnrgeedsicitnivreeporfolduocwtifevretiolritgya;ns, 3) the low fertility observe in the fist study at 25 mg/kg/day (55%) was not reproduced in the. second study, where it was 100%. Reproductive Toxicology Text Table 2. Fertility Index" in Rats Dosed with H-24768 Report StNuduymbers 0 1 D1o0se (mg/kg2/d5ay) 100 500 85 % 88 9- 10550 5-8 6: a Fertility Index = Numberof pregnant females X 100/Nummberoffemales tat mated F. F Offspring Data I. Litter Size, Sex Ratio and Pup Survival (Table 21, Appendix W) There were no test substance-related effects on the number of pups born, bon alive, andaliveon day 4, nor were there any effects on sex ratio, or survival indices during lactation days 0-4atany dose level. 2. Clinical Observations in Fi Pups (Table 22, Appendix X) There were no test substance-related clinical observations atanydose level. Clinical observations were limited to one pup in the 25 mg/kg/day displaying subcutaneous hemorrhage, a relatively common finding in neonates of this strain. 3. Pup Weights * (Table 23, Appendix Y) : `There were no test substance-related effects on pup weights at birthoron da4y of lactation at any dose level. G. Reproductive Toxicology Conclusions There were no effects on Py rats, Fy offspring, or reproductive parameters, including fertility. ~ The apparent increase in estrous cycle length and he decreased fertility reported in the first sty? ae unikeoy be test subanco lied ) -_-- 0s Company Sanitized. Doesnotcontin TSCA CBI H-24768:OneGeneration Reproduction Study in Rats DuPont 13784 ~~ ANATOMICAL PATHOLOGY A. Cause of Death - Py Adult Rats (Appendices AA) There was no test substance related mortality. All rats survived until the scheduled sacrifice date. B. Liver Weight Data - Py Adult Rats (Tables 24-25, Appendix Z) p"Treesstesnutbisntamnaclee-raenladtfedemaanldesrtaattsisatdimcailnliysstiegrneidfi2c5anmt ign/crkeagse/sodifntalhyievetreswteisgubhsttpaancrea.metLeirvserwweerieght raenldatfievmeatloesb,odreyspweecitgihvetliyn. tThheesseeglriovueprswweiagsht11in0c%reaanseds1w1e4r%e noofttahsescoocnitartoeldgwriotuhpmmiceraonscfooprimcales. evidence of liver toxicity and thus were considered a physiologic response to metabolism of a xenobiotic and were not toxicologically adverse. C. Gross Findings - Py Adult Rats (Tables 26-27, Appendix AA) Tnheecrroepwseyrweenroe tienstterspurbestteadncteo-breelnaatteudraglrloyssococbusrerrivnagtiboancs.kgArlolungdrolsessioobnssertvhaattiaornestnypoitceadloatfrats of this age and strain. D. Microscopic Findings - Py Adult Rats (Tables 28-29; Appendix AA) Liver There were no test-substance related microscopic observations in the liver. In aprevious 90-day | sotbusdeyrviendraitns's?owmiethmatlhee rteastts,sbuubtstnaontcef,emmailneimraatls,meixcproossceodptioc2h5epmagt/ockegl/ldualyarofhytpheerttersotpshuybswtaasnce. | oInr ftheemacluerrseenxtpsotsuedyd,tdoe2fi5nimtgi/vkegm/idcayr.oscNoepviecrthheeplaetsosc,elelvuildaernhcyepoefrtirvoeprhyhywpaesrtnrootphoybswearsvepdreisnemntaliens | `males and females administered 25 mg/kg/day based on the mild increases in liver weighs. | I i -- | Company Saniized.DoesnotcontainTera mis H-24768: OneGeneration Reproduction Study in Rats DuPont13784 --_ Py Adult Rats With Suspected Impaired Reproductive Performance Nadoulttesptaisrusbstthaantcfea-irleeldattoedprmoidcurcoescloitptiercs.fiMndiicnrgosswcoepriecperveasleunattiinonthoefrtehpero1d2ucpatiirvseroervgaenasleoafd 12 Py `morphological explanation corpora lutea in the ovary. for infertility This finding in 4 was Py females, which had decreased or no not test substance-related and was observed in 1,2, 1, an0d P, females in the 0, 1, 10, and 25 mg/kg/day groups, respectively. The causeofthe infertility in the remaining 8 pairs was not determined. E. Anatomic Pathology Conclusions tNhoe taedsvtesrusbestfainndcien.gsNowneardevperressee,ntteisnt smuablsetaonrcfe-ermeallaetegdrofuinpdsiangdsmiwneirsetelriemdituepdttoo2m5ilmdg/kg/day of physiological increases in liver weight in males and females administered to 25 mg/kg/day. --~ 3 HL24768: OneGeneration Reproduction Sudy in Rats DuPont13784 CONCLUSIONS `aUnndderreptrhoedcuocntdiivteipoanrsaomfettehriss,stiundcyl,udtihneg-ofbesrteirlviteyd,-ewfafsec2t5lmevge/lkg(/NdOaEyL,)t'hefohrigPhesrattsd,oFsye otfesftsepdr.inTg,he aupnpliakreelnyt tioncbreetaesset isnubessttarnocues-rceylcalteedl.engTthhuasn,dtthheeovdeercarlelalsoewdefsetr-tiolbistyerrveepdoretfefdecitn ltehveelfi(rsLtOsEtLud)yfaorre. lraecptraotdiuocntoibvseepravreadmeitnetrhseifsir1st00stmugd/yk.g/Tdhaey,ovbearasleldNoOn EreLdufcoredreppurpodsuucrtviivvealpaarnadmewteeirgshtisduring 25 mg/kg/day, which is the same as the NOEL for subchronic toxicity observed in both studies. --_ + TthheetNesOt sEuLbsftoarntcheiswesrteundyotisdedteefcinteedda. Tthhues,hifgohretshtisdosstuedayt,wthheicNhOoExiLcoilsoegqiuciavlallyenitmp{o0rtthaentNeOfEfeLctsasatdreifbiunteadbblye.to 1| dtheefiUnneidtebdy StthaetEesurEonpveiarnonUmneinotnal Protection Agency ** and to the no-observed-adverse-effect level (NOAEL) as | | no Compa-- ny Sanitized. Does notcontain TSCA CBI HL24768: OneGeneration Reproduction Study in Rs DuPont13784 -_ REFERENCES 1. RDeupProodnutctHioanskellELvaalbuoartaitoonsr.y.Un(p2u00b2l)i.sh9e0d-RDeapyorGta.vaDguePoSntutdHyasikneRlaltsLawbiotrhatOonrey-Generation (a-- nt Haskell Laboratory Medical Research Project Numbeor mfm] Study C 3 2. Levene, H. (1960). Robust test for equality of variances. Contributions to Probability and. Staristics (3. Olkin, ed.), pp 278-292. Stanford University Press, Palo Alto. 3. Shapiro, 5.5. and Wilk., M.B. (1965). An analysis of variance test for normality (complete. samples). Biometrika 52, 591-611 4. Snedecor, 349-352. G.W. and The Towa Cochran, W.G. State University (1967). Press, Statistical Towa. Methods, 6" edition, pp 246-248 and 5. Dunnett, C.W. (1964). New tables for multiple comparisons with a control. Biometrics 20, 482491. 6. Dunnett, C.W. (1980). Pairwise multiple comparisons in the unequal variance case. J. Amer. Statist. Assoc. 75, 796-800. 7. Tamhane, A.C. (1979). A comparison of procedures for multiple comparison of means with unequal variances. J. Amer. Statist. Assoc. 74, 471-480. 8. Kruskal, WH. and Wallis, W.A. (1952). Useofranks in one-riterion analysis of variance. 1. Amer. Statist. Assoc. 47, 583-621. ~ 9. Dunn, OJ. (1964). Multiple contrasts using rank sums. Technometrics 6, 241-252. 10. Hsu, J.C. (1992). The Lincar Model. Journal Factor Analytic Approach to Simultaneous of Computational and Graphical Statistics Inference in 1, 151-168. the General 11. CStoevpahreinasnocne,TWe.cRh.n,iqJuaecso,bsCoonm,muDn.i(c1a9t88i)o.nsAincoSmptaraiston--iSosfimNtuolniaptaciroansmset17r.ic17A(n2a)l,y4s5i1s-o4f61. 12. Fisher, R.A. (1985). Statistical Methods for Research Workers, 13th edition. Haffner, New York. 13. Selwyn, MLR. animal safety (1995). studies. The use of trend tests to Journal of the American determine a no-observable-cffect level CollegeofToxicology 14(2), 158-168. in 14. Haseman, J.K. and Hogan, M.D. (1975). Selectionofthe experimental unit in teratology studies. Teratology, 12, 165-171. 15. fHoarzAanradlyEsviasluaantdioEnvaDliuvaistiioonn,oSftSaunbdcahrrdoEnviacluaantdioCnhrPornoiccedEuxrpeo,sTuorxeicSittuydiPeostePnatyianlt:er,GuOi.dEa.ncete al, United States Environmental Protection Agency, Office of Pesticide Programs, Washingion, D.C., 20406. EPA-540/9-85-020. (June 1985). 16. (RXiUs/k2A8s3s/e94s-sEmNe)n,tCohfaNpotteirfiI,edSeNcetiwonSsub2s.t2a4nacensd.2.T2e5.chn1i9c9a4l.Guidance Document | 6 -- | Company Sanilized. Doos not contain TSCA CBI H-24766: One.Generation Reproduction Study in Rats DuPont13784 TABLES -- I~ w= | Company Santized.Dossnotcontain TSCACBI HL24768: OneGeneration Reproduction Study in Rats --_ TABLES EXPLANATORY NOTES Notes TestDays 1-73 = Premating period Test Days 73-87 = Cohabitation period Abbreviations G = Gestation Nin = Number DuPont13784 -- i --- Company Sanhized. Doss not contain TSCA CBI A ATER pers TABLE 1 `SUMMARY OF CLINICAL sums OBSERVATIONS IN P; MALE RATS won vr ome op og J HomEen uns sn frr o1 11 d i r2 2 am iP: F3 1or 611 d rT I E ErE SR E E . `Company Sanitized. Doesnot contain TSCA CBI F-24768: One-GenerationReproduction Study inRats DuPont 13784 ~~ TABLE2 SUMMARY OF CLINICAL OBSERVATIONSIN P; FEMALE RATS DURING PREMATING NUMBER OF RATS WITH GIVEN SIGN DOSE (MG/K`GG/RDOAUYP:): BA o11-0 1v-0 1v0i-0 2 2 2a OBSERVATION sAvcoapsECTA 17 5 o6 Statpis<tic0a.l09A)n:alysis: Statistical significance is indicated by the following &~ NCaoorncaphmareratanrm-ieActrrmiicctoamgpceaormiptsaeorsntisotfnoortcootnrtCernoodnltro(lDun(nDuentnt'/sT)ashsaingen-iDfuimcnaenttt) significant 2 nTerxotndtotecstont(rGoolncmkehaenerei-nTdeircpasttersa)nosiagnmailfysiecsantwere performed v2i5rr-o 2 07 37 Company Sanitized. Does not contain TSCA CBI F-24768: One-GenerationReproductionStudy inRats DuPont.13784 TABLE 3 SUMMARY OF CLINICAL OBSERVATIONS IN P; FEMALE RATS DURING GESTATION NUMBER OF RATS WITH GIVEN SIGN DOSE (MG/KGG/rDouApY:): N 011-0 1w-0 1v0I-0 v2i5ir-o 23 2a 20 20 OBSERVATION AsLcOaPnECIA 41 o7 4o 07 Statist<ic0a.l03A)nalysis: Statistical significance is indicated by the following ~ CNSooancrphaarmraeantm-reAitrcrmiicctoamgcpeoamrpitaserosnitsoftnoorctotorncetornnodtlro(lDun(nDuentnt'/sT)amhsaingen-iDfuincnaenttt) significant I TSreextnatotecsotnt(rJoolncmkehaonersinTdeircpasttersa)nosainganilfyisceasntwere performed Note: This table contains data from females with evidence of copulation observed --_ 3% Company Sanitized. Doesnocontain TSCA CBI H-24768: OneGenerationReproduction StuindRatys DuPont 13784 ~~ TABLE4 SUMMARYOFCLINICAL OBSERVATIONS IN P, FEMALE RATS DURING LACTATION NUMBER OF RATS WITH GIVEN SIGN DOSE (MG/KGR/oDvAeY::) : o1-0 2 1v-0 1v0io zn is v2irz-o 2 OBSERVATION a`vCoOvLOsRcEIDaDISCHARGE VAGINAL OPENTNG 41 2s 5 51 Stat5isctic0a0l 9A)mlysis: Statistical significance is indicatedbythe following = NCSaoovncaphmararatanrm-ieActmriictcoamgpceaorpitaserosintsoftnoorctootnrtCernoodnltro(lDum(nDuentnt'/sT)arhSaingen-iDfuincnaenctt) significant L eTrtenestesCto.nt(rJoolncmkehaenereiTndeircpasttersa)nosainganliyfsiecsantwere performed -- --~ E] `Company Sanitized.DoosnotcontainTSCA CBI |z I= 33 GA 34 gs 36 ga 9 59 gf g6 8 = $s 3 5 5 3 5 5 35 3 8 3 I~ 38 7 EF EN BR GF 3F SR ER ER ER RS $ 3338888 gs 82 3fe gaud gcan gafn gaf o5fd 3oAf 244% ga3S 5438 gaE8 o4nS E Ld 1d id |~ 3i SEL ese s os aos [1 ! EOTAITIERE Lennon 1 1 og %| | 3: : 3 :2 | = i, i L1 $zs 6F 1 s 3 gs 38 Sled si % i SELT Ae chiosmiegsy E al g : 28 FE i $7 83 ZBoTe ogSaag8 eRF elFOIEigi3 1i it Li | ofi i| i| {i 3 = 3g : HI $ 1i7usg8et gf & HIE 8 . oibgir Ge 8 8 8 |3 HER0ELF % Feaials Digi? s 300 D8ESHES CompanySanilized. Doss notcontain TSCA CBI ~ 5 33 3 3 3 53 8 3 g I ed ok oef a3 03 o8 of oF ef 22 ue 5 2 ow BE RS Je q* 2 % 8 9 08 9 hd . 5 a = Oo =z a ii:d i Ld1 ~{ i4 2 |S 9B HG Gel AE Qe 2a 8 oe ho 8% f= me Ze 89 J O43 oO de 3 ~% 3 2 fi8i o0nc afsf 52 2323og3%3873= GonanySat Sov voconanTSACH | | : 12 og ac gg z [BEETLE EEE I. I~ gE:l ZZ . ; .o TP3 5Ha5Ih: ` gEEo, EgLE8NE =o 8%e%s i Biber, 5 i| .3 2 BE oa os hLl:afialll: Lt i Fini i jlaeg | i ComanySent.Doe etre sccm ~ 3 | 2 3 83 38 : 87 57 BT RR BR BR RR BS ERR z Eg2 ig 8 338 3 iz e9x gay% gon% gvee ce e33% 2a9 gn4a 3c8o oo4o8 2 3 3 5 5 3 3 3% % 3 38 7 I Th 35 fF 24 4g 24 4 36 36 38 ; o g | ig : 2 | Sh ogi es sos oss | Lj | FompayStn.ovenTEACB "z 3 i o & g = g . LF od Z ga gy = | s 2 di: 1 C ~ |fBE eTOF y acd | F2 EE , 84 h En48gii 3 i ii | io gd |bog d1a l|iael | Bilan Lg ; Jil . Company Sanitized.Doesnotcontain TSCA Cii ~ F 3 B du wd de F ge gr Sr $a we we ig o $2$s 32 s2s S&S & s5s.8 8s 8 88 fe 375% 97 02 qa an AR a9 od va 1 E] La %e Ze 9% ~3 nt Og Fe en Sn Se 2 I| ~ FE ge 28 ae 44 gd 48 Bd Sd dd de 8 5 g 8 88 88883 2 5 mmmgoriaoroanam 3g : 5: : 32 ; & | od AN 58 8 Coss Ewe | `Company Sanitized. Doesnotcontain TSCA CB: | ~ | Fl 2 | | 3| 3 1 o3d 8 I~ 1 3 2 BR gd gg J. PH iso oC = 2, 3 13 : 2.02%3 1F3 fF% gs 7 pig . Fi Pas Pl 5 ggoL. iogEnidl Fda 52: :b gge Eof ||Ppyigfgbfltsiiel |3 fi F8gitae i 3s: A 8cromi2 `CompanySanitized.DoesnotcontainTSCAcal |3 |2 : 9 g5 23 39 . S a o g f2 a 52 3& 3& 3a5 I 4% 5%igd i38 3&8 . o1 b g: wo | gd = EEE EE 2< $3, 3 # 5 2d 3 7 3g 2 Hit z1 : 322g 6 3: EG$d4ee 3 go F blogd 23 8 isis p[EpitcsH, ox oa, gE3i9$8855d3885Ec Pisiiias 3i ogihleadssifds [EET HIER Company Sanitized.DoesnotcontainTSCACBI rm 2 5 cs zo i g ft oaanERa fg | EE EE : ||| gt aed iz . 4a.5a .a08a 8i 8 : Bao ddEd gf 2 ) z %i5 i3 | J1 | |[31d ~ = | gg 5% 3i7 1g5iE6EliE Eo Pip 2: 13 : dGiilaets 55880 13 doq o1a s {ifHiied iid 1 iif: iPiiinit 3 3haiiks & 8ciom2 i | `CompanySanitized. Doesnotcont TSaCAiCBnI og | , FE Z 52x geo 2 27 2 ~~ 8 | EI ER sd 11 @ Eo. BF sit fe 3 37 eo} i - BE Hh ldg Di ogfaigl Company Saniized, Dose netnessei= =n By L. Kl |H Bi | | 5 z B% gq g ge 4] 3 i. Jit ii Boa a = : . 8 it iogie |Ldi3 I. ~ i =o G5r1 fJF siiianl g | Lil gone CompanySanitized.DoesnotcontainTSCA CBI - i so 3 LEE EEE EEE gE B gd ga g6 80 ge ge 20 gd gd ge i 92 oa a am me sh om am a am : odd dnagads zggq 1 fo | J AE= E= RE EARE RESE RERSE ss ss ss ss ss =3 i 5 a FI z i Ez BE I~ |i } CompanySanfized. Doesnot contain TSCA cat A. 2 fEa EN<3 2 2 : I= bE : :2 :I, 4 3, 83% 3 :Si9 HPhiRl . 5 By 4 15 31 8fo 3h Bqguiat 21 (Hing CLYd EgHkeaihilt i3iih: 2 E0TC0TE EompanySaniized.Doesnot contain sca cay | | EL ununbuuuay : x 3 Be odd dd dedi dd dad id ) a4 3 ty 88% 8 8 88 8g qd id|1 5f2 Off h Co 2 d s 8 2d s 8 8 2 CompanySanitzed. DassnotcontainT5cA car -, i i, i sc Hr EE Cl g i cs 5 iF 3 - 2 pig . Toi.IER EE FSI Lil 2 = i Sead b] ogE1, M|ayid Ld8 C2OS TGREOENE|p E FH1n11 i 2 52 Ey IL s 2 i isis i ~ FEE 1 CompanySanfized.DoesnotcontainTSCA car | I~ o Boa gt 27 a0 edd gd at gh ed g Eo ES g EREEEEEER 8d dd gd Sd ga ge gd ga ge ge EL ofa asaads 52 . Ei 3 Ee: AAA Are = =m om om om om mm = om 3Z i: ~i ! 82d FR 2C2 R 3 `CompanySanitized. Does not contain TAA ARI "oz i 58 gd gJ #2 gd 2 3 2 : EEZ RE 3 iET4 3 iE TE og 22 TE, qs T EFesdfibiy 3H1 | |I Pog ||e3 ~ f8 s = Fhe z 5E,FL.F iBFh4akt lin 2888528. ih! ||E. kh Reoiiiggiia-r iDirnle PE | = CompanySenitized.Doesnotcontain TSCA CBI | "z o 2 Ho G8 33 8% 9B 82 8 38 88 28 of g z if , oss g2 8 i, FoR | f 3 zs 3 3 = = = = = =z = shige ag ZIRE EREIRR RRR REE Ce ee eae a Gifs ts HENBLUBREE 88 8 8 8 FHuUu RUu VLAIuRuEy 3 2. Ly3i 5 B0yh S 2s 28 4 2%334 33F: { I9 EI 3 { EompanyDoSe are ncoitatnTzcec.ar - s g 2 _3 3 2: 3 :s?i | pd pb dE 0g oq 5 34 Li 2 = PL CEs ff fin | 1 8Brj k| isgihl:i |bd4 32 88 EEjRitse ! - BompanySanitized.DoesnotcontainTSCAC81 Tt 3 8 g- ge | g g I. oS ad5 oF& wd i7 z BR ge ge ge gd 3 2 i oid 3 Bog 5 3 37 sienna 83 0. 4o 553 8EC oATE Era) 12EI%5,0 < ii THI PhoEpap ef fr :2 g ! 3; B3igiSi9e5i0e fi.301 | 3 i fiji 5 L2I t&ozog oN ul R fH T 58 8 3 goatee [I = 3 $8i{EEs Ed Biomi2 { | "CompanySanllzed,55s int antl =" ~%( CompanySanltized.Doesnatanmieta ena mar |3 & 38 8 ZEIT g 3gf BEERTd 5 1883 &, 3 LDR BEEZ : EgR 3g 1EFB 3ai,4l8o : g 3 3 3 3 &4%i% | 5 SS oS So os] B5F3 $[iifs 2 34 8giiyg : g3 | 1 gE 3, dii55n8i |5 b| y Ere E5 izds Lo. &0% of cinkd 8 RssIiE! PLoid g2 Ligigeslss { CompanySanhized.Does notcontainTSCA CBI ~| | famosas shins , 2=2 Bslhlii%iaigd % Jaizid a CL JiPaEld : E EOBLEiEEsReEs i,o0d} yf 3Poidd & 2 1 1 | {| 8 | feelin 8i 3 B3Eig ggg yHN1.4LhHidi SEITEN g fa ddim ian CompanySanz. Does notcontain sc car |"oz3 | dew ea b2 2. 3% 28 3g 28 aE ofnl rs : 3. S 58 og =F af Ee Pia fgg So oge B 1E.E0 flEISaIEhCiiC3bTe E4a8 silfyh HgesLpe bh nn 1A E>sE C aEg hR Hs EH BHE R TEE nRS IBTR8R 7TsHyugEiiR fe90n8iiE 33 298sl 825 fATE EBe uGnRE EF fCHiUisbi RBiEiEe:y 3 Fg i's 5 BEpiaie giifsl 3 iFOs RT REfRiel finns Hand in 8 osm STEREE |8 |g ~|g1 { "CMipanySenlized. DoesnotcontainTSCA CBI | 2476: OneGenerationReproductionStudy in Rts DuPont.13784 I~ TABLE21 MEAN PUP NUMBERS AND SURVIVAL: F; GENERATION DOSMEA.TE(RMNGA/LKGG/RDOAUYP):| o1-0 1i -0 vToio v2siz 2 2 is 2 sBoorrnn alive | Day 4 MEAN NUMBER OF PUPS/LITTER 10l.s4 1B3l.a5 1160.77 1155.00 103 1B als ls sBoorrnn Alive Day 4 MEAN NOMDER OF MALE PUPS/LTTTER 77.86 77.34 77.22 77.32 7s 71 72 71 sBoorrnn Alive Day 4 MEAN NUMBER OF FEMALE PUPS/LIFTER 67s 6a11 7753 67.s0 bel 60 74 27 survIva (6) GSeesxtaRtaitoino I(nmdaelxes) 10000.053 10000.055 1000..050 10000.058 || H0o4anba3yBVoirnabAilliivtey 5599.74 5598..0 25009.20 95904s 36 Staspiesrtciecnats LAintatleyrssisd:eliSvtearteidsthiacvailngsiagtnilfeiacsatncoeneisLiivnedipcuapt.ed by the follosing (p < 3=+ cNPooacnrhpazamaranat-mraeietcnriictcoamgpceaormiptsaeorsnitsotfnoorctootnrtceronondltro(lDum(Dnuentnt'/sT)ashsaingen-iDfuincnaenttt) significant fTersetndv6teCaotnt(rGoolncmuenaeneseinTdeircpasttersa)nosainganliyfsiecsantwere performed DSrtaasteinstteidcsfvoerreinpfeorrfmoartmieodn oonnlyc.ombined pups per litter only. Male and female data ore - Te CompanySanitzed. Does not contain TSCA CBI F-24768: One-GenerationReproduction Study in Rats DuPont13784 --- TABLE22 SUMMARY OF PUP CLINICAL OBSERVATIONS: Fy GENERATION DMOASTEERN(AMLG/GKRG/ODUAPY:) o1-0 1v-0 1v0i-0 v2i5zz-o NUMBER OF RATS WITH GIVEN SIGN OBSERVATIONS SUBCUTANEOUS HEMORRHAGE o [3 10 NTOUTMABLERNOUFMBLEIRTOTFERSSTAGFNFSECTED 00 0o 0o 11 `TOTAL NUMBER OF LITTERS 22 21 1 22 PNuamrbeenrtshesoeustsiadvee tthhee npaurmebnetrhoefsesliatrteerstheaffneucmtbeedr.of pups affected, the numbers in i S(tpa<tis0t.i0c5a:l analysis: Statistical significance is indicated by the following = CToaczharmaentr-incrmictoamgpearitsesotn ftoorcotnrternodl (Dumnets/Tashane-Dumnect) significant 92 NTeroxontnpdatztoaemscototni(tcJoolcnocmmkephaaenroirsei-onTndeirctpaosttcerosan)ntorsoilagnna(ilDyufsnienc'sasn)twerseigpniefrifcoarnmted i i & -- Company Sanitized. Does not contain TSCA CBI H24768: OneGenerion Reproduction Syin ats -- Dupone13785 TABLE 23 MEANPUPWEIGHTS: F; GENERATION ooswErs(uon/Lk/GoroRvneN::o 1o102-0 w2o7o fvniio vi235m sm rue wezGs (grams) oo 670.8 6700 6.60.0 6.50.5 oy Woe 12am 0.50.4 10402 MER nce pup vBiGuES (grams) Day 0 G00. 690. 680.6) 6.70.5 Dey 4 Hae mse mas 107M Day 0 ESOwens p6m5o0Mpup vm6io5u0rs6)(grams6)30.5 Seva sobmmaaryiszed se: em10(0Se0a.nd6ard De1vi0a0ti0on.)6 10.602 1010.2 ERracTiatCiont amaiyeis: Statiatioel sigmiricancs is indicated by the foiioring cRoecmhrmatne-naartmiea tiagTeerpaastr.iecfLnooroSatercnoaniteeok l(heun/aT)amhsainoen-s Frmeeorns) signiticans eR tenetn(tSioneormbeestten-betrepnaateese)20ssieosmbiytbieosantwore pertoraed e Sora: StatisticaR l amivees were coR nducted n on the combined pup weighs. || { EE CompanySantDoeis oztcdont.ainTsoA ror ~g |g |3 | = BR gg de sd | 2 3 | s83 : nn HHS & o I | 2g gEq E3 . 5 g.is.gYl 2% FERRELRR 3 8: faidlE PoEid tEi T . : ii g| if Ld5 gpiu nd 5 bs | 2rd FE | CompanySanitized. Does not onnisin TSCAGi | | I~ 4 z | 2g,< enz.383,88% 2 c 8g Eo suai 3 fama 5& i E gE coo 2 3 E8433: 8 a J s2 lnig2ul | 3! 21 |3 fos 5k I3 5 8i7 i8g: pl iri | | CompanySate, Doss otesiTEAC | |I 3& |. ], g: "U i i 3 i i z AE | 8g4E,i Pid : i ul 3 5 Hid %| 3 i 2 : i Dag oi E |i 8 Gf e803 iE is a. Pd lg mnStessesrteminTsoA "oz : ' $ Eo | bo ofeyt ew ol 2 go |: I~ 8382 i PPodg = g Edi i iPoE Z |Id2 ~3 { noi P| e iI hlHEiRif BEF i `CompanySanftzed. DoesnotcontainTSCA ear ~g Pom T | Frade wa aE | 5 ! Loh aE CoErRe 1bBE hg EERE EINE IN" bog 8 "i gigi 1 8g agg of IH I. iE FHPH iti Company Sanitized. Doesnat cantain T&A FL i3 2 [I T ii i i | 2 seollbofiH : Pos Cd g i onrodoron ini get o 4 g giamly gt d3 P| ihEgg dR4B dFRfI Em R Cl EE PF imTIaME)] ed Company Santtized. Does notcontain TSCACal H24768:OneGeneration Reproduction Study in Rats ~~ DuPont13784 APPENDICES ~~ | sm CompanySenitized.DoesnotcontainTSCA CBI 24768: One-Generation Reproduction Study in Rats --~ DuPont13784 APPENDIX A CERTIFICATE OF ANALYSIS I~ = --- Company Sanitized. Does not contain TSCA CBI 124768. OneGeneraion Reproduction SudyinRats Dupont 13784 DRueogsoSpypoiimtnCihSenemmdiiss "ingen DE 19858 DuPont Specialty Chemicals Due: Jemary 5,200 FNaokoeuwtLDas8b1o97r160or05T0osology &Inds Modine Ateation: Gre.g Lado ies,rPhy .D. [i CERTIFICATEOFANALYSIS ] P ani SSehtans Ronis we SD-- ubeernTetion RAeppo eA:ySnheSne.amirs es Shaan Sutneey. | --_-- Company Sanitized. Doesnotcontain TSCA CBI HL24768: One.Generation Reproduction Study in Rats DuPont 13784 -- APPENDIX B PROTOCOL AND PROTOCOL AMENDMENTS | EE | `CompanySanitized,Dossnotcontain TSCACE! A -- = -- ~ venml - `Company Sanitized. Doesnotcontain TSCA CBI H-24768: One-Generation Reproduction Study in Rats DuPont 13784 ~~ R216Oe mention erodyeinhst Damn TAOFBCONLTENETS Pe OBIECTIVE - 3 SPONSORANDTEST FACILITY. 3 `REGULATORY COMPLIANCE....... . a STUDYDESION concen SELECTIONOFDOSSLEVELS. a AFO vide sm---------- -- D.SvafitymB.rckoandDispos oFWassMoa rn a E PRaurdaonli(ntPioRn . LI -- --_ EI BE reedit ngyeeovatniiongrmmmmm----------------------------r--] J. Getto roots. " - --" LK. ALonctaoinoinPPoacoeldones. - Tm Te DATA ANALYSES. rl "RECORDSAND SAMPLESTORAGE. megpipmdh `REFERENCES rd SONATURES..... a || ~ - = CompanySanitized.DoesnotcontainTSCAcar 24768:One Generation Reproduction Study in Rats DuPont-13784 -- 52068 ConOmenAgri Rts Demin INTRODUCTION NDOoEtLt(sirte b2ei0tseeve)rfoe evprodceiYveteoxiinofethe e0t mbytanco. ees oECTIvE Tchoncebpjticoin,vaendofptisadtyitotf moaivlaelnetdTthoereeffCetCofDtoSoDt)sGtSaBnRcrecsntvheegceosngenfaccinn,, SPOANDNTESST FOACILRITY TlEhficTsisvePyohinesddstepsoNnetshmecorstdupbsmyoDrduaCeomthpCanhaye,mhiWcialwmSeilnstgctnnnt,shDreeWlpovrreiks,AeuTt(hDheCssSzpEso)in,osonrFsopunr.oTvhewsoly EiLlTdlbse PcoornkddiotNaemoDuurfseantdHCaocmpkalnLybNocesvoeay,fDoexlHaevaerthaandd ERnegocns lASneenscesS,eevicles (RAS) Tks Labo(ond tmecs ile), ospoctr,NewTry. REGULATORY COMPLIANCE ~ LTahbiosrtnoryyiPlralcbteicceSenadnodceerdincicmcphlaioscceoWnAstUr.Si.EhPtAhTeSCCEAD(4P0CFiR pptoef1G97so)Gdood L`aGbooodrLtaebyoPrtorryira(ci2crevSinidan 19(6d75)7pcbahiahnerNditnE8N5V0I)M2CI9CAHrEeMsOo)fn17 andMmApTTvoaipEll be orumrtedihen fv rept. ------------ eerie | --- : | Company Sanitized. Doesnotcontain TSCA CB: H24768: OneGeneration Reproduction Study in Rats DuPont13784 B06OneGeineroding nhs Duin STUDY DESION Stud Parameter Studs Dates vniilteiCoonmopltetsiounbDttnsceadminitration. OFebrsuart3y01,e9,220r00034 (Approvinite) GrpNumTerreatmentGroupsandDayDessge PIMs PyFemale No/Growp_Dely Dosge (mg/g) m1o0 mvoo %2 o1 (CWoonwt)r) vieoo viioo u2 2510 (eimgehd)a) ag fo wheofmeidYo wg even 5 ALS Animals PAredgunaMtatFeesmales NFeirgprsgnat Femles Sacttecsactnle Schecle AOlnedsoiyonf ifatcetsi(oan.distinofstudyicle) WOintdhparydegonfancttfimaolnes: SELECTIONOFDOSELEVELS Thtesdwoistehcenvee-lgenfeoatrioin rdepyrowherteisoneevealdbas gnthweheictrssfroemnd9f0-odaeygreapgroedctidaynin epvraelmutciionngpweerirodd,ocoodabbitciroang(a0vpa1g0ew2iwtehek2)5,,g1e0st,atoiron5,00amndg'kgtdiyond,uUtnidnegrath0e-cwoencdkitioonsf Serlseyd,indheexrienwPyastieo iNnOaElLdfoosgreopurpoeci.cEtsisveo vacteilonlesn.gTthhiwsawsapsrenegceodninrPeyducntilicnlnthse cdoosme gpoangn,itehdefLfovsicecegicealdsgPpiitcncdeoosfeidwichh3a0r0gmgs/ckgl/eda.yintclhurdeadvdeercsree,mentsin ``ocdoymwepioguh npdareadmeftferecsnidnf1o0o0dmfidcien5c0y0mmdgr/edducegdmroaunpsoirncolfumdpedlraercattiiconnssitne.meAadnveireser, sansddmuanmbgercotfipounp.sbDoeveanledveblosmofal1,iv1e6,, up2su5rmvivakldidnagywlaecrteateione, ddufphewuirgentbaitchy, || wrheeprresee2nt5mheNgOEfLfkoexepppecdrteodaodpiryottdoiuxiciveceeloenfclytmsd1 mkdaysexpected | || gs | --~ --- es Company Sanitized. Does net cn=tain TSCA CB" RS SS ours _ NS -- Pe -- ee Tnions 5 resm S i Dl aaS alae TB p,ThE s ra o rEer --- reeetrmfell) PB tARyT L ETT h FAeeRsASinesrr ~ v Temmerne astmTepesmeng ratty trianha aSE EE, prS DS E a h E Ry e Jy s I a SE AA aer es crv --_ --- | . `CompanySanitized.Doesnotcontain TSCACBI HL24768: OneGenerationReproduction Study in Rats DuPont13784 52016Ono OmemicnRproSbycnihotns pre b Pepantion sFtoreod rsommotfeutmhpseelrtsaulaittalncuiesiedo.hOenvnecheiscelfea( genteddstovri oatgee)twc aibillltbye ehparsebpd eaerenddtaaibllyisahnedd, teFtmodrmmwwialilhtbehpeirveephoaircelndewvisilclebewdeoeckumaenndtseodre threftiigneydseedc.oTndhsemetofmhixiongtdhe Sampling `Scameplaes,ofaedadctihonesatl. saumtpilones(msapypbroextiamkteenly3thmL)sirllibtofnthe3tidmyesddiurcecitnogrthesdedsyig.neeI. ASnuablmyitsteesdwdiollralyealslercopnrcpeanrtrtaitoinont,tuhiefoAnmaibtiycoaflmiCxhiengm,isntdysGraolutpyo.t SHaamspkellelswillbe Fa`rAs damepsinwigfomriotmyodfomeiprxeipnagractoinocnenntearttihen,beognidnSnihngooufrtohoem toedympersdab md dayrfigeredability. + C`Soinxicnedeepreindoennvtrisfamipclteisonf:rVoemhieacclhee--t1ssacmtpclneTieltlFbecoolmlemcteud:-l2tsipioens Analyzedimmediselywhen sampaelteakesn + Reolodm Troeommtpemepenr5atthuoruuerfsr:oTfeivsehFoousrmuthlean1tsaialymozpnelde * GReencfernitgtieornavDetariyefeid:caTtieotn Fanaolyosims:ula3tsaimpolens ~~ orfetmhaien3inmgusnagmlpesl-eA-lAllerle1d$ahyosuerfsigoeormsttieonmpers `Se"coAndddiaensdeTshcionrcdenStaramtpilonngvsei- fcrtoimodnosspreprstionnese hemiddieandendofthesty `iSlamlpblees aolfytzheevdeihnimceldesiddel2ysFeomlglloewsifngosmbemaicshicoonn.certi ofthe ormltions IcFosnadmiplteed.cOanndtaybsesnumyp earsttahlksipee,cihfeiefdortimmuelsa,titohnesyewmialilrbienfgcgleenwdiolinagywlelsbecnrbeed `oAnoalmytticaleChmoerpaGdmrdotoeipionalss daynratletycseiysd.eT.heanalmeythtodieecdvailllb dosmentedinthe SoftyPrecautionsndDisposalofWateMaterial `cGoonotdamhionuatsieokneepfidnogspinrgossetcoisnviplrlebpeaptriaocnifocielditioeasv.iTdoptaevtidalkhienactohnhtzaca,cgdlsomveds.wil be ettnawnhceenwhialnbdelihngonehdeitnhae cthees.miscuablctHmocoedo.Drodsoisinnggforomitricmnsv.uiTlnllsbepaireptoaretindheitno,ptrnopesry ertlitedses.Animalcoscsee, ces, and seddoingformulationswillbo ncinerted. | --~ | | rr ------------------eieeiweseeeebeeen | Company Sanitzed.Doss notcontainTscA cay H-24768: One-Generation Reproduction Study in Rats DuPont13784 --_ E2016 OneGeneric RerSouyRnts Dua 4 D. Avid 1 Species(Srsin) ColCDYEDIGBSR rts 2 Rowonfor Selection Tsheecrto.wmamsesenlbedycteheddefoguitdilsinsetsu.dyThe2Cr:aCpDre(fSeDre)BsRpseaciienowrasrecphroosduecntbievceatouxsiecietxyteensstiivneg a btahcekrgrcounodinfomrmatDpiuoPnoionstaHviuaslkelnlfoadbmotrhtseiryr.aThties , tsheisnuiplplse,cmod pnrevsiosiuts addbuleceerrseweliidhve Lolengevty,hardiness,mdincidenceof sprtaneous isos, 3 some `ChasesRiverLaboratorieTsn,,Raleigh, N.C. 4 Descipion Aepppprroocsimiameilty5l61y0d8maalofyaangsd,a1n08dwfeeimgahlirntgs(13n1o-m17a5egrfeammaslmesdib1l2in6g-s1)5,0egqruaemast,aedpieocbteivey. 5 eiedion a Pe rm Temporecage idetifiction b AfterAmigntomTreedmnentt Grogs mh wilbeamr im endianante ilbn cudnthe E AmdHusbady 1. Eovinmental Condtions AonFim50a%ls2o0o%s.Alvlibmealmarinotoamisnweidlalbneaetcieipctaalbllyeltuemmipnesrtaetde(oTfuc2r2e.ce3raghdt)oenltaiv12hhuomiwdeity lighdckcycle (pproximitely0600-1800hour) 2 Coping Allma rtwillbehousedindividuallydingnc mtingperiodsindines ect,viremesh cages. | --~ -- `CompanySanitized.Doesnotcontain TSCACBI H-24768: One.Generation ReprodSutucdtyiinRoatns DuPont.13784 5216One onionReprod ynht pr 4 PtetmdPremtingPeriods ALtwillbehvmedindividuallyintalesdel,wiemesh cogs. b Coabiion riod Aclobtidiiolnlbpeehrec fdeamslerseswiinghp,eeviidnenscteoiflecsputledli,ovniveilmlebsehhcogve.edAndvitanldyohfthe polycabopnets GetsionBoiod Dan02 Females behousedindvidalyindenies doe,iremehcages + Day2ODelvry Females illshoodndvicalyinpolycabontsps. 4 LatinPercd Adifel ilbehousedwiththeiiterinpolycachontspans. ihlelscebitnie tnelg,viemed cagowillbeepndedabove geod. Plantposns 3 et , LALrat bwi5lD0l0b2oapirdoebvirdnt.op weeadpletedPACNotstcn tin, ne,Cetied Rot. owas Wit om UnitedWtDelaver will avlble adm, 5. AnimeHestMenitoong Aprsogsepaecniftieed FotlhloewDiunPgopnrtoHcaunrkeeslsLeabpoerrtfoorrymeidmpaelshoahandrstnveicimrCtrsmmicnraitcilnvgls Teloshse hi kdb peteio pochesini tetofthe dy + wWadtecrchmrpsleeatraanealyzedflBailcots,dhepresenceofcolons eo, i + Foodsample re lyzedforts util,spo and figalcus |i + bSyatmhpeleofpoemnferss shed coges ndcoerocks yzedtocnn alee ition | -- see ---------- | `CompanySanilized.Doesnot containTSCA CB H-24768: OneGeneration Reproduction StudyinRats DuPont 13784 --~ B16 oorGriesApronsoy nhs Deis Creequitreimeanntismnaldfeeioweexcde,egdiaerdmsaxbiymthuemmcoincrcetrionos omfekeyt cerctifaiemdiisni,iionnclsuding preecsiefniceedohfetahveysectoanltsa,milntacnxtisn,clohwitohnetmedihmyocarcboonncse,rntidcrdgaatcepdhbeyphhietmeasn.uTfhaectser Wouldntbeexpectedtoimpacth negrtyofhesy I`aThborrieaylanhiemaatlhvsned srnvair.crmDeinttaalmrnemiticninigmprogsreapma is mfirnoimsteurcedbeyctohneteannddimnagybe inclodedinthefinalreper the dsretionofthesadly director 6 Quine RthtesLawbiolrlbteeeyuAanrietmianledVfeoesleurtin 6odaiyss,densidgtnehee.nlecfothsty vhsarora of tFhutphratsiosoofnadricmoee.iDeependepntiupsondthiensegfihnedipnrgstfuptehreiroddiwsignlobdeicepcrrepcseideedstomsahyabckefoc bemprloyye vethteercarno.nofhe dydiecerthpthologitmagnedtothe dy,cxthe Fo Rdomizaion --_ Ruatmofieagchsneeewiadlnbdtoexropenrreimbeiyratzlheigormouolpet.Trhecetrly acncddbosyhmwuelidigrhtezalndnaraatnidtomsilnysoicnnin ichhe eanbodyweight ollgropevwithinaar ctAstitialyGrn(5 0.05) tAnhimtaaldstohtdoepslcexecdeissfipvesiig.h Use prior othedatofdosingwillbe removed rom R+ita maamyibgeneediloatefsrgruoupinchtohredstrotckcs,norfhestudydirecor + ielvilbuetisonicby carbondonde thomsenmd scarcewithtpahelgical s------e-- c---- Te ------------ Company Sanitized. Doss not contain TSCA CBI H-24768: OneGenerationReproductionStudyinRats DuPont13784 --~ 20068One GnrvinBegoniRats Dein 6 Para(PRas 1 Clinical beervtins Catsgweilslbeexsarmiifnacteido.nsAwLielsbetconneduwceteekdlayhLoasutgnhedathilyptrhermoiutgihnogutfehedeing,dgye.stMioons, nandd Scortsiont periobm desh,acvio oohrodfe toheeam ipppecarl rance. ts wilbe incividallyhandledndcarefullyexamined 2 BodyWeightMemuements a PremtingPeriod AILPy tswillbewighed nceaves Bb GemtdLacitatioon Prnods Pyfemaleswillbeweighedcndays0,7, 14, nd21 of gsttion. Pyfmales illbeweighedcndays0 nd 4of tation. Fcoenmtailneusetwoibheowetievgihdeedncoenoafwceoepkullyatiocnhihcakt.copult anddortdeliver ter,mdmaleswill 3 FoodConsunmdFpootdEfificoienncy ~ a PrmdingmdCotabiaionPeriods acipvpicrofxooitdmecanssttndmepylio7yn0.vFiololdbceodnlsrummipntieodnwweielklnycbceoduegtheorumtitnheepddeurriiondg,ecncdhianbgiation. Ferofm fhesisvdcieltleibremeicnaanltcicountsyedndbyweightdd,individ diyfoodconsumption ndfood bh GetmdsLatiionoPerniods I1n4i2v1i.dunFofoodcdocnosnusmupmtpitioonniolflpnrtobgermeaysufreemdafl r wimlallbeosewcitrhdoeutdeovnideednicteioofn dcoypusl0a,ti7o,n 1n4,d foc males.Foodconsumwpiltlicotbnemessedding lctticn. Ferofm ftheisvdcietleibremeicnaanlteicountsyedndbyweightdt,individoediyoodconsumption ndfood --~ | 86 - `Company Sanitized. Does not contain TSCACBI 24768: One-GenerationReproduction Study inRats DuPont13784 --~ 20968One GemrvionBegoidy nRes pen HE Bredng 1 SofCohabitation An(imdalsevilsdlabyeicohfgocuoshneabdiatetateirodsn)p.proximtely 10weeksof xpostothetssubetaice. 2 DuorfCoshabsittioonPensod Anchiambailttioinlplbereiohdowuislleedndiiiltehveidmeonmceionfgcoofpdualyati1onoifscohtsaebrivetidoon.2weskshave lapsed. The 3 EvidofeConpuctieon (sOpnecremdaiinlvy aocghfeaivmaaglnsesiaalmplllbee.eTxhcemdinaeydevfiedtenecperoefsecnocpeioaftionnitsabvaaegrivneadlicopduelastiigonnpedhgdoaxy Ootgestion. 4 Coousing, `oEfatchheosammaedoislalgbeelceovnetli,niunahlleyhaoluesesdccange.O1:n1btoh sdsavyitchopauldatinonliscsoenlfeicrtmeedd,,nntsheifbelimnaglmwaille botrbaack noinsdvieciarcgrehoeraidng. mBaasyebenctohoeocuetdcrangaeionfitnhtehefmiarnnmetr ogutalnindedaatbhoevdei,scerxecteptwoiftthhe fderyendtimealtes,,ttohpereomdacleos . Evcetoof nitedr 1 trou CycleBvaution `tVaaggeisnoaflltahveaegessatmrplcoeeuslwesi.lVlageicnoallllecatvedagdealsaynpflreosmawlilPbyefceomlaelctedsibengoinndienrg 3dweeteekrmsipnreitohreto `mViatgiinnga, alanvdacgoenstianmupilnegswielil cboepeuxlaamtiionnedscmiocnrfoisrcmoepdi,caolltyhfeocodhatbeitiatuiotn ipeoriofodhheasaegnedeodf.the troncyl (dtm, trv,pros). | --~ | -_-- CompanySanitized.DoesnotcantainTea 31 H-24768: One-Generation Reproduction Study in Rats DuPont 13784 B10 conOmenten potion ny nes Diss J GetsionPeeters hAeerenednfghre caceadiotnoporlic forfoneiohdeae2vi0doenfcegeosftipoun tfoixmn)dfeSmaelmeerltes,il be heseat emvicedyfo signsof everyand ofp. KE Lataion Process "Thepdraiynwghielnlbdeleivenryics chomphledtiddavedsgxratmeidnaeyd 0opx tomoprmee.lbAeLhaichnxdisnpecesc, oc shncemapp willberecorded 1 DayoPotputm LiCovmeplnedtdedeaLdipvueppspiscecxeetcawrilhvliblelbcosucrtveiddbyuslxywesigchmed posite teedeliveryis 2 Day Poaputm Litvhsppeein(beyadcatpetrawiinl) bme cdodntiesddboydswexisthdotipnvaitdahlyoweiggheedn.A,llgvillbe L AnonicPahicsy ~ 1 made a MebodofButasia Cotondiceetna b PutmotenExanintions hAoeBs hpettial(gfeonedrtdiaondtacwciildelnbtelsyiKtide)dotosgrsocpretholgiccaltexramipnaiticono,hinecnhidnogf cCdoohiaongbepdfteehmcoasloretfwoasciwwlhillliblocbehgexraetmeciicnndgenoddif.deAtlespercemesselncepenrasonddcuiilmobbnseorpfrooefsleirrmvipanlagr.tmtTaipcepnrsosperisondacliv RorpantiefePkcpahlexoampincesl I~ - | ss Company Saniizod. Dosriotconiain TSCA C81 H24768: OneGenerationReproduction StudyinRats DuPont13784 --_ 5106 Ove Omni epyi ihts Dares Tehigfnollowpirnegsiersvua iannsdpalpgrcteoscntisvewifollbpoesciobllleect rreomidlpletyhaellosgsclseximdinbdyicn OrganWegfohmPuiAdnsls DeLfivie.as NeTusne CallciolfromFPyeAddies SacificedbyDeBsiagnses Totat [Epioddmyise OvVeiapwid) Grom Tnieevis' CSoepmiontgVeGiimne Cae Tot omitttosempdc pp omrcol nticealf ppeiirnAliD( .tler Theessdo o icn e iv ited Crmty ntceoemed fe hah ppt od xeewi Hirstto1p0ahcaolnomgeitailveexiammianlstmiunmobfetrhseinlvaechviglrlobuepc)osnurdvoicviendgftao tschheediurle1d0spcairfeiceintthse(Fhye mnathe nhidgTh-odmoaseghoivgph,dotvhee nvedrscrielellbegreoxvampi.Inedhoerthwefired1m0epntarrealliredtcsh(ahnegeisikn1th0e iver TCoomnastmcotmiivedmninoadlommsbeersronpaecihncgrdoeg)tosfuravtihveirngdolnehedoufleedmdbeianmot-hceoFeyrmeidl.eid ~ arti eve" c`oRnecpreoidvheatives,oopr dmeliovferthseaitthyhifmfpipeiinegd, poerofduactiivnepteocrumsanyccisc(t5yo,efel mtcoomuirttse),will cvvastaetadd.mMiocodscgircoaslley.inSelnecdteadrgreocscgtmervartoimonlsofwoawdhic ameidcirtosclopvilsdailnldgoswbould tfboeramdeksiiovfeheege,ac,otoa,tis,,opsoadeidenrnnaa)twiiilllcsvcedi,udtweiltlge,necraalllcyuclt,bwedproceed. fo mice vation. aeossseaiiond romtrrtistimtaaysbefRoutnddeeproorcsecieddentaildyesKfilolepd(osauteeineptyheogmiicl), vation thediscret ofthesty recto ocreprocictveLoicelogit. | Tviislslecstbreomrorsaesreedmfoovremdifcrroonmsstudyv(foatertt eu-cornsnidgereebdodoywiyghbtyahnetecdyoy0), | cor ce pithciogit. | 2 ompung | Offspring hataefound dead ering the actionperiod villindergoanextemal examination. | | I~ | -- ee "CompanySanitized. Dossnofconain TSCA CBI H24768: OneGeneration Reproduction Study in Rats Dupont13784 12016CorOmripointy Dare DATAANALYSES whensflowingtai isthevieof productos ftirwilbe cladfo hs Fy BeroFdencnsoncCatlctvatoens Mainghdsi() - NNunobecCohuleal 100 Flys) = NobePe NumberCpu xm Gottiminder = NlafbeemreQcueiiLitvesnp xn Tsphlaesamicens = NNambberedIhnpplbaotimonstes x0 PpsBom Alive(%)' = N Nu b ooftPm Ppupar sBBb eammAa live. x100 Vibldexty - NaNctbmrPppsaeAnbliDrauepdoialifng x100 --_ T ie dgaE iadeyiT mbet e.eyio.ed vx eds leeed REE IEE -- | 0 | CompanySaniized. Doss nol contain TSCA CBI H-24768: One-Generation Reproduction Study in Rats DuPont13784 ~~ 20163OnemicsArdenSoy has Statstca Mithods Darin FbooanydCVwooamgsem:oiess oFmcoenwsdiranecngn Lome [NoereremminicepNayapettsite | AMoaTmoyd"Ry|| vCooney igmi nl || tine P1c53eVsoenteedire r[ermrr Crit eg CoctrmAmiesofrgened? Boigi Niomvoaptwaescs,sei) sdrisdmmint --= (eCbeoeiSeirSeaWirlkWe aiSpdh,otKLo nWal a Ant.nhtDvot HoefDet i ~ FUxhopsetrermpiorcstmaetenftohrtraetpioclevoaflletcicdnt0Thsepeveltofasogtnhicimtceeamcetanediilsbpo<e0e.5d.0 `Adionlsitio tswillbs oc,md thrparametersmalyzd, fdeemedneces. RECORDS AND SAMPLE STORAGE ; bLaebtoirtnoenytsypehcieficsortsytewh-epreecfhcerwaowrktwa,ssdconhsa.sAplerlscornineglila secaonrddssurpeeorpireecoorfds will |i `osDguipnoanlt HeacsakreldlsLsapobnrsosr.yp,iLeddcFhiertdeezsNteimonoofahnedCeokrsuebya,ncNee),vwail,Dbeelraewatrneedi | on MountainRecordsMimagemen,200 Todds Lan, Wilmington, Dvr." AHeskeanLootbheote.stSpbeectiamesnwsilpbiesclee),drfwaciti,epitphossnsaldepiornweil beDrukaone:d W`DiunPeir nHgas,keDlelvLaabso.rer, Newat, Delawareo, ronMoxetnRecordsManageme, | --_-- | | --_-- | `GompanySaniizod.DoesnotcontainTSCA CBY 24768:OneGeneration Reproduction Study in Rats DuPont13784 20165One Generic heroSuiinnks pre REFERENCES 1. EPAFIFRA GoodLaboratory Prodi Sanderds (40CFR160) (1989). 2. OEENCVDMPCriIncCiHplEesMoOfGSo)odLaberaoeyPractice(wrvisdin 1997,publishedin 3. MAFF Jp GoodLborsocyPrastcsStandard (59 Noh No3850). 4. RDeupProoedt HaskellLberstorUy.rg(u2b0l0i2)sh9e0d-RDeapyeGeatv.DagueStidHoisnkReltLsawboirtahtOonrey-Generation {4 HekellLobo oryMedi Beach ro No] 5. SLteavrHes.(n1O9e60,)leRdo)bi,upspttn27s8-f,2o9x2e.qSuaelintdy oofvUinres.iPCvroo,rnPtlaorAliytoobP.ruotbaibolynansd 6 Saspainrgo),.SSB.aond mWiak2,i,M9Bk1.6(a111965) Aneyesofvarianceetfsnormaly (complete 7. S3o4a9d3e5c2c.r,ThGeW.loawnsdSCtocehrUann, iW.v.e(rr1s9s6s7,)i. tSowtyea.iacalMthods, 6edition,pp246-248md 5. D8um2m5e1t.,CW. (1964) Newiabes formukiplecomparwiihsaoconns.Biometsi2c0s, 5. DSuatviee.t,AsCsWo..(751,98109)6.-P8a0i0rwisemiecompirisonsi thewusvasance cae. J.Amer. 10 Teqouhaol,vaAnCc.es(1.97J9.).AmAcero.mpQarai.soAnosfoprsoc4.,ed4urTeI-fo0r mollcompanofmeanswih -- 11. KIeuAlmaelc,SWatHi.sa.nAdsWo e47,Wl5.8A3.s(61219,52) Useofranksincne-canealytsisrofivaosen. 12. Dum,0.1. (1964)Mltpleconwitngrrenasutms, Technom6e,4s1i-2c52s. 13L.TiineaLrCM.o(d1e99l2)J.oTuhnaelFoofoCormApuntaatitonAalpapnrodaGcrhapohiScmaulStainteioouss 1n,f1e5s1n-c1e65inth General 14, sHtaumdmia.n,TJeX.raandtHoo1g2la,no1,6gM5-Cy1D7.,1.(1975) Selectionofthe expeswin minetrnaetlogay | --~ : -- . CompanySaniized. Doesnotcontain TSCACHi 524768: OneGeervion eprodscion Sty in Ras Dupo 13784 oe ~ B06Once Rien soya Dunas 2068, OneGertion Rprodgin Sg inRis Soe SonaToRas sin GEYTIN bo 220k2008 -~ QkSAyTio 2eaSa-ms | | J Eh || `CompanySaniized. DoesnotcantainTSCACBI H24768: One-Generaion Reproduction Study in Rats DuPont-13784 -- B06: OneOenicnApraoyisnha pre 24765One-GenertionReprodtionStudy lnRts `Woek Request Nmbed Service CodeNumi PROTOCOLAMENDMENT | Th PctoceisamenssdFelelowds: 1 FFruegpea5n,tMin,midSaatmplMierntgh,ode .sA,dBs.iiTsetttSiucsnt,nrcsp,4c. pTasrgSetspahnwceeAdhemilioswtitnign:, Tehstrtdsmsocbemwciellvbiolalbde einni bygcaglsanc ids.alyp.etra nt fo amanexposac. The Do+siAnlglSicmhaeldulveilbedss diybygavagefospprimtely T0day pictcchabtion + `nPydmalreirngetshndco,bfiteamtailontpesrsihoodw(inpg0m2oeevei1d5e)n.ceofceptionwillcotstobedood alerts andofthecohabitionperiod wel cis. + Tomales homing evidenceofculationwilbo osedthroghontgdtin. + Pregnant malesinth procesofdlveryoeshowing signsofdeliverywill ctbe dod. + Femaleswil bedosedale elfenites,hugh tin, oii. + Femalesthtdocdeliveraltevillcei tobedod etlsci. ~ dReitnogrtt:iTphriegsnaencttiSonowass weivlelrbdssddotsoecdeaaorddeleicveirbinghetdroeinogtcohsaocdisScfeo.r llimal, 2. Psaengteen,ceM,acthearinaglstaon:d"MAetnhioldsToEo.nAsniwmialllbeHmuassbatnsdsi,nc1 .EmvnaiccspttaiaeCmopndeirtdioincse,offit. 301880%-2160C8((rpgeteedd 2420.52-060C%))andmaining tm ceptable lativeumictyof co`nRastiiotnealret:wTitohiHnacsdkee aLaupbdoirtteedysStaOtPemetnhtefAormiamlaWrelofamretAectmp(AeWrA)s,mmdtuhmsiTcLeAyR'hstis titeforLaboxtocyAina Rewech)Geeforth CareandUseof Laboratory dnc. --_-- | Compinty SanMized. DoesnotcontainTSCA CBI st mim poe Sr R Be e pn sa im, SE e S BS A T , aa i R A E i eEr ye , e p . L y oSiEGrREA, ~ E a RAE E Ssme ime . i sete | oi fr a 20-mac-300 - : : CompanySanhized. DoesnotcontainTSCA Cal H24768: OneGeneration Reproduction Study in Rats DuPont13784 B16 Crome eprosdatynisn 24768:One-GenetinReprodugion Rudy Rats WSoerrkvRiecquCeosdte NNuemc PROTOCOLAMENDMENT 2 Dis "ThePrtacl i menadfoellodws: 1 aPaes,ReultryCourtp sncl,pe ce: "1`h9Sa9in7dcopr re(uc59onNscbikniESNmwlNVitoAhC3dI8ve5C0HE)Ee"CMwDCiIPdhSrI(iTnmhcdegMoAfwGTeoEoJbdopLldaGboadnLaPbrcircaceeyesPravcitiecde L"iW1o5i9r)ddpeaurrbclPiorcmicipneaSEtaNwVdCiMtaHhGthE(e1OM1ENCOeDb)Porn,iNcGupEmlCbeDec,rfGaG4ot5o,d)L1i9b98esrdaMPARrE1cp(esivGicosneed 1b.Page16,RefereesRene ber 2d,diet(bes ibly: E2. ONBVCADPCrIinCceHsEofNGOOooESdCL)Da,b1Praa7ris,e,y1P99r8.icesesisdi 199,public 5. MAFF opm Good beyPrciceSd (1NohaNo.623) Ric: ToupteGoodLoborsery Prodi SmadsfaOECD mdMATEJp. 2.cTaagme 1i3,nMatt4eri9ipaolsrannssdM,ethchoadn,gLe.AnidomicPthlcgs,L. PyAd byPodms orem - "hiGtupsthlelsoigcniscca iravtioncphesdimsaytbienfetreparbdoocge.s,o iddyesdeixrpeescTprodtive oilogit" Batra: Toupdetetheprofoesvaetisn grosless. --- Bompany Sanitized.Ooonotcanfain Tarn mar _ E ==E = = HEEe E=E= EB=EA Er EE E E E EEe Ee=e=EEIEEErlEoe re ia e |eS--|om-- =n =T nrSe--CE te m m, eae e--oe-rs--o. rAeaeee a SexRatto(Covariate:Nesersae) E LLr Rs | E CRa E EE eCmRn AE u B e iR se dl `untilnosignitrefndiisdceteactnedtForliterparametes,heproparticn ofaffectedpupsperMiter or ~ CompanySanitized.DoesnotcontainTSCA CRI H24768: OneGeneration Reproduction Sty in Rats Dupont13784 B16.CnnOemonin tric ny nh Domine 24765 One-GeneticnReprodoctionJudynats WSaerikcReeCqodde NNuummbbeedr PROTOCOLAMENDMENT 2 (Catined) Ksmmeitaefsenisy e<0d05.Adcsatinetswillbe,mdchprsmed, t2b icPaRgee16p,R latcse seas i staloowcm on(ceense 5dongsr nthetitis mes 32REEOFRBEARCTEIPNrFCiRnEcASiG ples ofo GodLoaPvreirl cyePSrs iacet(ob e(r10CeFy Rd161099,7 1p98l)ot 54 MDVAuFNFtCHpConHeMlGoLGodaELcb,ecyrt.ey(0P0r3i.c5eSDmaGdosv(e59SNinedhy aRNot35s50)Co Gnticn T5 R isiLn UT ptbibedRaaktoDuRpeoHx koj ty 7 SLGpiot,15r,o(p1m5ap6d0W)2I7RR89tM7BtS.e(ta19ot6rc9)uAtssotfoyeyrieosf,P.eFublmCeAotleeinnfsocaPlrob(acsaypnldSesapilse & S5r n5e3dTcheee ,laWrsSi avad Covmes,tW.0. 19l6o7)s Sati Methods6 tc, 46.m2d4485. --_ 05..RDDreiomnne,75CCWWo..s((1199680)0PNewwbiesnbskcpapci orpe moip vtiiioc.eBciuomAam0,er5Sk2-as9k1 112.KTfeasklhaeWAHrCae(97W9ay )l.lAscWcmApm(ii 19a5m5) Uprsoocreskfcmcolcehecarmpaiys omveisnewi.thn, Aonle 113 HDSuaami,C01ha9c(e91.9)674,T)5Mh3o4kFi2p1cl cAutyouetAiggrroen maSsi.mTbaemefsenc6e2413h5e2 Ge Lin. 18SCNootalneecapmTWeahRhm,ieCTgauoncsk,pbsCaroonnoom,Dnm(3i8,n9o.spc tmsSSotom fS1Ni1om1pia4p or5yanm1er .c1An3so y46s.o1f61 1716..SFtrtay,oRlwoSksL..Rn(1J1998o,99m9,.SaThaoettmheeaAamMaaerhdiondCftoorelRboeegdacfctrThmoiconoreikgm)-1s13b4eri1a5t8b.,1l6-8HloletcNnetweieYon,rndk. 18T. esraano,,1 3,16F5o.7g1 MD (1975,Sion optm ly dics | NRhekeeniteormTehpietptemioatonrachdoiefcs"mCoorepoyroaLireisgCoitoepisalsodx gyintisti:caadlem,aByeheeSlietim -- [iCompany Sanitizad.Doesnotcominin sca cp H:24768: One-Generation Reproduction Study in Rats DuPont-13784 R106:OneGeAgrn o iou n isha 24768One-GenetionReproduction Judy Rts ior Request Nem! Service Code Nom PROTOCOLAMENDMENT 2(Catinnd) Di Approvedty: Toe Mees. -- Study Dircor Approved: mToeh Tm ov e Sudy Adhor --~ --- EapanySantized.Does notcontainTSCA CBI H-24768: One-Generation Reproduction StuindRayts - DuPont-13784 - APPENDIX C ANALYTICAL DATA --_-- Company SantDoasoet d. oei==+514 H24768: OneGeneration ReprodSutucdtyiinRoatns Duren13784 -- H-24768: ONE GENERATION REPRODUCTION STUDY IN RATS ANALYSIS FOR H-24768 IN DOSING FORMULATIONS Medical Research Project Number: AHnaaslkyetlilcaSlamRepploerNtuNmubmebre:r: {-- |C 24768 -- SUMMARY. On October 30, 2003, dosing formulations containing H-24768 at the concentrations of 0.20, 2.00, and 5.00 mg/mL were collected. These samples were analyzed to determine concentration pverreipfaircaattiioonn aanndd5l-evheolusrwreoroemcotlelmepcetredatounreNsotvabeimlibtye.r D6,os2i0n0g3 faofrtemru7ladtaioynssoffrreofmritgheerastaimoen. and. analyzed for refrigerated stability followed by 5 hours at room temperature. On December 15, 2003 and January 26, 2004, dosing formulations at the same levels were collected and analyzed for concentration verification. A 0 mg/mL (control) sample was collected and submitted with each sampling. H-24768 as used in this report refers to active components in H-24768. Concentrations of the active ingredient (a.i.) in H-24768 in the formulations were determined by high-performance liquid chromatography (HPLC) with MS detection. The formulation vehicle for the study was deionized water. Results from analysis of the dosing formulations collected for concentration verification and stabiliotny October 30, 2003 indicated that test substance was uniformly mixed (C.V.'s =0.6, 0.5, and 0.9, respectively), at the expected concentrations (+ 4.5%) and stable in the vehicle for 5 `hours at room temperature. Results from the analysis of samples collected Novembe6r, 2003 from the same preparation after 7 daysofrefrigeration indicated that the test substance was stable for both the 7 daysofrefrigeration and the 7 days of refrigeration follobwye5d hours at room temperature. Results from the analysis of the dosing samples collected on December 15, 2003 for concentration verification indicated that the test substance was adequately mixed (CV of less than 10) and at the expected concentrations (+ 14%) in all levels. Results from the analysis of the dosing samples collected on January 26, 2004 for concentration verification indicated that the test substance was adequately mixed (CV of less than 10) and attheexpected concentrations (2.2%) in all levels. H-24768 was not detected in the 0 mg/mL (control) sample. | || --- | i ee CompanySanitized. Does not contain TSCA CBI H24768:OneGeneration Reproduction Study in Rats DuPont 13784 SAMPLE SUBMITTAL Test Substance Stability Analyses Samples of H-24768 were supplied by the study technician near the beginning and end of the study for stability analysis and analyzed by the DuPont Regional Analytical Services (RAS). Methods and results for the stability analysis of the test substance are documented in the study records (DuPont Haskell Laboratory Medical Research Project NumberOR--]Svice a 3] Formulation Sample Analyses 0O.n20O,c2t.o0b0,era3n0d,52.00003m, gs/ammpLlewserferocmoldloecstiendg. fTohremusleatsiaomnpslecsonwtearineianngaHl-yz2e4d76to8daettceornmciennetrations of concentration verification and 5-hour room temperature stability. Samples from the same preparation were collected on November 6, 2003, to determine 7-day refrigerated stability and 5hour room temperature stability. On December 15, 2003 and January 26, 2004, dosing formulations were collected and analyzed for concentration verification. A 0 mg/mL (control) sample was collected and submitted with each sampling. All dosing formulation samples were collected on the same day the formulations were prepared except for stability samples which were analyzed when received or when reanalysis was necessary. --~ `The formulation vehicle for the study was deionized water. METHODS 1. Analytical Methods a. Recovery Sample Analysis Concurrent with water was tested dosing formulation at the targeted low, analyses, mid, and hriegchovleervyelosftHo-c2o4n7f6i8rmftrhoemssupitiakbeidliNtay noofptuherc analytical method. A stock solution ofH-24768 was prepared in 50:50 Nanopure O(wmaitde)r/aancdet5o.n0itmrigl/emaLnd(huisgehd) lteopvrelepianr1e0t0hemLrecvoovleurmyetsraimcpflleasskast. tThehe0.s2ammpgl/emsLwe(lroew)d,il2.u0tmedgw/itmhL . `5m0a:n5n0eNraansotphuerdeosiwantgers/aamcpeltoensitartisliem.ilTahrecosnacmepntlreastiwoenrse. then processed and analyzed in the same. . b. Dosing Formulation Treatment | Each dosingsample (1 mL) was diluted to 100mLwith 50:50 Nanopure water/acetonitrile to | ddiilsustoilovne wtihtehH5-02:45706N8ainnotphuerfeormuwlaatteri/oanc.etoTnhietrdiolseitnogasnaemxppleecstewderceonacneanltyrzaetidoanftoefr afpuprtrhoexrimately | 0.0005 mg/mL prior to analysis. | . --- Te | | H-24768: OneGeneration Reproduction Study in Rats DuPont-13784 ~~ c. ChromatographicConditions Concentrations of the active ingredient (a.i.) in H-24768 in the formulations were determined by high-performance liquid chromatography (HPLC) with mass spectroscopy (MS) detection. HPLC Instrument: MS Instrument: Model 2795, Waters 2Q, Micromass CoLlCuPmanra:meters: Mobile Phase: LunaA3u~2C51m8 M(2)a,m2m0omnmiuxm2amcemtate in water BC--2a5cemtonMitraimlemo(nAiCuNm)acetate in 80% ACN/20% Water GTriamdeie(nmti:n) ~~ %A %B %C Flow (ml/min) 0 0 0 03 5 0 0 10 03 65 0 0 10 03 651 0 100 0 03 88551 00 1000 60 0033 2 0 0 6 03 ~~ Column Temperature: 30C Injection Volume: 3suL Column Switch: 1.25and 7 min MIoSniPzaatriaomnetmeodres:: Electrospray, positive ions | CCaopniellvaorlytavgoel:tage: 3305VKV Source Temperature: 120C Desolvation Temperature: 500C | Data Acquisition Function: 6-2 TBA ethoxylates: SIRof 690.5, 734.5, 778.6, 822.6, 866.6 m8z2;T0B-7Ameitnhoylates: SIR of 790.5, 834.6, 878.6, 922.7, 96.7 m10z2 0T7BAmienthoxylates: SIRof 890.6, 934.6, 978.7, 10227, 1066.7 m/z; 0-7 min |~ or | BompanySanitized.Does not contain TSCA CBI H.24768: OneGeneration Reproduction Studyin Rats ~ d. Calibration and Quantitation H-24768 s a _I DuPont 13784 _-- NA AA A primary stock solution of the reference compound, H-24768 (test substance, purity 994%), was `made in 50:50 Nano-pure water/acetonitrile. Calibration standards were prepared on each banraalcykseitseddatyhebysadmiplluetisonbewiintgha5n0a:ly5z0edN.anoTr-ippulriecatewaitnejre/catcieotnosniotfriclaeliabtractoinocnenstorlauttiioonnss wthearte made. and peak areas were determined by electronic integration. `The calibration curves were generated by regression analysisofthe peak area data obtained from chromatographic analysis of the calibration solutions (see Figures 1a, 1b, and Ic for ~~ representative calibration curves). Data for test solutions was fitted to the calibration curve to determine the concentrations of H-24768. Test substance concentration verification in the vehicle was evaluated by calculating the coefficient of variation (C.V. = standard deviation/mean x 100) of the measured concenrations in the duplicate samples (concentration verification) for each dosing level. A coefficient of variation of less than or equal to 10% is the standard criterion at Haskell Laboratory for acceptable distribution of the test substance throughout the solution. `The mean result of the concentration verification duplicate samples for each dosing level was used to determine the concentration of the test substance for the respective dosing levels. Stability was evaluated by using the mean result of the homogeneity samples as the baseline for `comparing the corresponding stability result. . _ a. -- Company Sanftizad. Does not contain TSCA ~ --_ | | | |" | | H:24768: OneGeneration Reproduction Study in Rats Dupont13784 ANALYTICAL RESULTS A. Test Substance Stability Analysis Analyses ofbulk samples of H-24768 near the beginning and endofthe study for stability indicated that the test substance was stable for the duration of the study. The stability of the H-24768 in the samples wasbasedon the physical characterization of the test material. The analyses consisted of the density at 65 C, the upper cloud point, the surface tension, the residual cos ethylene oxide, the 76sJ) appearance, and the percent fluoride. This work can be found in the study The following table summarizes the results of the analyses for stability. Tupeof Amivses SuDmaptele D@en6siStCy __PUpopmer(CClo)wd Su(fyseeTesms)ion EihylReenseiOanlde Appeare Fluor%ide 240s 1m 91s 213 xD Ok 3408" evs 1am 913 219 ND ox 56 + Rrocedeinepeftorweaigehdinonhrees-aammpllyesfoorfprlley.. The origin ays was ower hn pected du to sn crore B. Chromatography "The concentration of H-24768 was expressed as the average value of the concentration for the components peak areas. H-24768 eluted from the LC column as resolved peaks with average retention times of approximately 2.0 minutesfo--)36minus and 5.2 minutes SEENE] ach peak area was cv: `Separately with the respective calibration curve. The concentration of H-24768 was expressed as the average value of the concentration for the components from the three peak areas. Representative LC/MS chromatograms are shown in Figures 2(a - I). Test substance was not detected inthe 0 mg/mL control. C. Recovery Samples Detailed analytical results of recovery samples are summarized in Table I. The variability of the analytical method was demonstrated by the coefficients of variation of the recovery results at each targeted dosing concentration over the course of the study. The measured concentrations of H-24768forthe 0.2 mg/mL level ranged from 98.0% to 107.7% of nominal (mean percent recovery = 102.2% +4.1, C.V. = 4%). The measured concentrations of H-24768 for the 2.0 mg/mL level ranged from 91.3% to 107.0% of nominal (mean percent recover=y 100.0% 6.5, C.V. = 7%). The measured concentrations of H-24768 for the 5.0 mg/mL level ranged from 90.1% to 102.4% of nominal (mean percent recove=ry 97.4% + 5.2, C.V. = 5%). Based on this data, the analytical method performed satisfactory for the all concentrations in the study. Te Company Saniized. Doesnotcontain TSCA Ce HL24768:OneGeneration Reproduction Study in Rats DuPont. 13784 D. Concentration Verification and Stability Samples Analytical results from dosing formulations collected on October 30, 2003 and November 6, 2003 (7 days refrigerated) and analyzed for concentration verification and stability (5 hours room temperature and 7 days refrigerated with 5 hoursroomtemperature) are shown in `Table Il and Summary Table 1 The following table summarizes the results for all concentration verification and stability analyses. PrSeapmapralteionTyDpeay Nmogm/imnLa.l Measmulred" % NMoemainnal C(V%)._%SuNboimliinna'l _%NSuobmiilniyal Conc3e0n.t0r0at0i3on 0 Dt - ow om = 020 01,0191 955 06 920 a0 20 19419 9%s 05 950 985 50 487.480 96 09 990 1030 ab MSaemapnleresshuelltsdforhtohuersaanoaloymotfemtphdeurpaltuircea.te samples, 0 SSaammpplleesshhlelddrreefrfiiggeeraateeddffoorr 77ddaayys. thenheld horsat oom emperre Denotes none decced %SNuobmiiinyal os 90 90 -- `The data for samples collected on October 30, 2003 and November 6, 2003 indicates that the test substance was uniformly mixed in the vehicle at all levels (C.V.'s = 0.6, 0.5, and 0.9, respectively). The test substance was at thetargetedconcentration in the samples (+ 4.5% of nominal) when collected and was stable in the vehicle when held 5 hours at room temperature, 7 days refrigerated and 7 days refrigerated followed by 5 hours at room temperature. Test substance was not found in the 0 mg/mL samples. | |~ - ws Company Sanitized. Does not contain TSCA CBI H24768:OneGeneration Reproduction Sudyi Rats DuPont 13784 --_ E. Concentration Verification Samples Analytical results from dosing suspensionspreparedDecember 15, 2003and January 26, 2004 and analyzed for concentration verification are shown in Table Ill and Summary Table 1. The following table summarizes the results for all concentration verification analyses. Preparation Nominal Da mg/mL. MeasumrLe.d" A%vNeormaigneal o__v% 15Dec2003 0 No - - 020 017,017 860 1 20 179, 181 90 1 50 26Jan2004 0 451, 469 Nob 920 - -3 020 0.194,0.197 980 1 2500 250003,, 417948 999758 41 =b DDeunploitceasteosnaemdpetleecteerd.evl were analyzed. CV. caleulie1d verify uniformityofmixture The data for samples collected on December 15, 2003 indicate that the test substance was uniformly mixed in the vehicleatal levels (C.V.'s = 1, 1, and 3, respectively) and that the test --_ substance was at the targeted concentration (+ 14% of nominal). `The data for samples collected on January 26, 2004 indicate that the test substance was uniformly `mixed in the vehicle at all levels (C.V.'s = 1, 1, and 4, respectively) and that the test substance. was at the targeted concentration (+ 2.2% of nominal). Test substance was not found in the 0 mg/mL samples. F. Conclusions Analyses of bulk samples of H-24768 near the beginning and endofthe study for stability indicated that the test substance was stable for the duration of the study. Data from the analysis of the samples at the start of the study indicate that the test substance was `mixed uniformly, was at the targeted levels and stable under the conditions of study. The data for the concentration verification indicated that the test substance was mixed uniformly in the vehicle and at the targeted concentration during the study. Test substance was not found in the 0 mg/mL samples. |= Te | Company Sanitized. Docsnotcontain TSCA CB! H24768: OneGenerationReproduStcudtyiinRoatns DuPont 13784 PN `Table L Recovery of H-24768 Added to Dosing Vehicle Sample `mg/mL H-24768 Percent Ey Nominal Measured Nominal RECOVERY" 0208 0224 107.7 RECOVERY 0201 0.197 98.0 RECOVERY 0.206 0.207 100.5 RECOVERYTM 0206 0211Mean 11002224#41, cv.4% RECOVERY RECOVERYTM RREECCOOVVEERRYY 208 208 1000 201 215 107.0 220066 21.0898 190113s Mean 100.0 65, cv. 7% RecovERY 510 497 975 RECOVERY 5.03 5.00 994 RECOVERY 5.05 455 90.1 RECOVERYTM 5.02 514Mean 1024 97.4452, ~~ CV.5% ((BA)) PPrroocceesseeddwwiitthh 7c-odnacyenrtefartiigoernavteerdisfaicmaptlioenssarmopmlessfirnogmpdroespianrgedpOrceptaorbeedrt30o,b2e00r3.30,2003. ((0)) PPrroocceesssseeddwwiitthhccoonncceennttrraattiioonn vveerriiffiiccaattiioonn ssaammpplleessffrroommddoossiinngg pprreeppaarreedd JDaencueamrbye2r6,125,02004.03. | | || || | 108- -- | Company Sanitized.DoesnotcontainTSCACBI H-24768: OneGeneration Reproduction Sudy in Rats DuPont 13784 -- Table IL. Homogeneity and Stability ofH-24768 in Dosing Formulations Sample `mg/mL H24768 Percent Type `Nominal Measured Nominal 30061-2003 Concentration ConTrOL 000 Nn" -_ " " 020 01% 020 0191 950 95.5 Mean": 0.191 +.0.001 95.5%) CV.06% " " 20 194 20 192 970 960 Mean: 1C.V93.005.0%1 (96.5%) # " 50 487 50 480 974 96.0 Mean: 4.83 10.04 96.6%) CV.09% 5-H. SRtaoboilmitTyemperature --_ 020 0184 920 20 190 950 50 495 90 7-DayRe#f1rigerated 020 0.85 925 " 020 0.191 95.5 MeanTM:0.1c8V8.02.%004 (94.0%) # 20 197 98.5 n 20 196 980 Mean: 1.971001 98.5%) CV.05% # 50 529 1058 n 50 501 1002 Mean": 5.C1V5i1d0.%19 (103.0%) 5:Hr. Room Temperature" 020 0.185 95 5200 419958 9990.0 ((8A)) TDehneoatveesrnaogtedmeeteacstuerd.ed concentration, average percent ofnominal (i pareeses and based on average | --_ () Smteaabsiulriteyd)s,amsptlaensdharedlddevihaotuirosn,atarnodocomeftfeimcpieenrtaotfurvearaiafti7tondoeafydrsuoplfirceaftreigsearamtpiloens (mean result, n=). Te Eompany Senitized. Doesnot contain TSCA CBI HL24768: OneGeneration Reproduction Study in Rats Dupont13784 "TM Table INL Concentration Verification of H-24768 in Dosing Suspensions Sample Type `mg/mL B24768 Percent `Sample Date Nominal Measured Nominal Concentration Verification 15-Dec2003 "ConTroL. 000 No -- "n 020 0173 865 n 020 0171 855 Mean: 0.c17v2i4i0.%001 (36.0%) " 20 179 805 n 20 181 95 Mean": 1.c80v.01.0%1 (90.0%) Pl 50 451 902 n 50 46 938 Mean: 4,c6v0.0.31%3 92.0%) 2`6CdonaTnR2O0L0 000 NDA) -- ~ " 020 0194 97.5 n 020 0197 985 Mean: 0.1c9v6.10%001 (98.0%) "n 2200 129080 190.000 Mean: 1.C99v.01.0%1 (99.5%) " 50 503 1006 0" 50 a 048 MeanTM: 4.8c9v.0d.2%1 97.6%) ((BA)) TDehneoatveesrnaogtedmeetaecstuerde.d concentration, average percent of nominal i parentheses and based on averaged measured), standard deviation, and coefficient ofvariationof duplicate samples. |- [TTw p ------ 24765 OneGeneration Reproduction SayinRas Figur1e ~ RepreAsnalyeticnalCtaliabrattioin Cvurvees f SEt A Duron 13784 1 TEETER @ ~ lL h 0.00" o%0 0.50 80. 0.80 7.00 EB E EREe eracrnoou-xsw-uanurerraasr tions ) lLTE -- B23 TE TH ET Togare 17 Caltraton core soma eiesionatsoteplcae pesvgs xcltrsion lionosf --_-- | Company Sanitized. Dows not eaminin aca ca HL24768: OneGeneration ReproductionStudyin Rats ~ RepreHsPFLeiCg/nuMrS2etCharotmatiogvraems Dupont13784 j ME ca hromatogra of he0mgm (con. to amplefor AGRA Retention timefor ciforthe H-24768 is approximately 2.0 minutes. Pir 2: epee LCM ron of Con olf ro m. m Retention imefo ti used for he F-24768 i approximately 3.6 minus. Te [BompanySanitized.Doesnotcontain TSCA CBI H24768OneGeneration Reproduction Study in Ras 7 `RepFriguerHePs2LC(eC/oMnntSiCtnhuerado)mtatiogvraems Dupont 13784 e RorTT y N m S e T ohar 3 Resemion time for oc-- iorth F-04765 i approximately 3.2 mn -- Figure 2d: RTCeorpmmrcaeetsneatnttaoatntoidnveifLehOdeMtroSeprcnehsreoonmtmaattiovagerofammfromaiomoefn 0s0m00.109--6SmWpLl. T0h2aminnLmeHs-s24e7d68 dosing | --_-- | CompanySantized.Dossnotcontain TSCA CBI H24768: OneGeneraionReproduStcudtyiinRoatns Figure 2 (Continued) ~ RepresLCe/MnS Cthraomtatiogvraems Dupon13784 Figure 26: RfeoprrmeusleanttiaotnidveivLeOdM1S0acnhormoimnaatlogcroanmseonrattShioGn ofE00E00R3 mYioj.tth T0h.e mmega/nmmLeaHs.u2r4e7d65 doing --_ `concentrationofthe representative formulation is 0.196 mg/mL. | C1 | --_ Figure2f: fcRooernpmcrueelnsatertnatiatotiniodvnieolfLuttCeh/dM0rSe4pcrhensoremonimtnaaattliovgceroafnmocrfemornatalSheoaonnEoifs 0CE109060M3mmigEai.DthTeh0e.m2emag/nmmLe.aHs.u2r4e7d68 dosing -- Tw Company Sanitized. Doss not contain TSCA CBI $2476: One.Generation Reproduction StuindRayts --~ RepresentFaitigvuereL2M(CSontCihnrueodm)atograms DuPont13784 Figure 2g: RaneaplyrtsiceanlarievfeerLenOceMsSolucthiorno.matogramfort0ho.000412 mg/m. H24765 PN | Fre 2h RersLOMmNSaaemitovgrner | analyticalreference soon ovomz mm.12068 | yf -- CompanySanitized. DoesnotcontTSaCAiCBnI H4768: OneGeneration Reproduction Study in Rats Figure 2 (Continued) ~~ Representative LC/MS Chromatograms DuPont13784 Figure 2: R`eparnscyaaatrifneeeLnOeeMsSlcaihno.mtorantrofS --_ 0.000412 my. 1124768 Lo Figure2j:RepfcrooenrscmeeanntttaiatoiinvoendioLlfCutt/ehMdStroecpnhroremsoiemnnaattlaotcgiovrenamcfnofrroramiaotnioo=nfs0.002010.51 mgofmL..tohef 20.427066m5g,/mThsepmiekaecdrdeodsing |-- | Tw BompanySanitized.Does not contain TSCA CBI H24768: OneGeneration Reproduction Study inRats Figure 2 (Continued) ~ RepresLOeMnSCthraomtatiogvraems Dupont13764 Figure 2k: Rfoermuplatrioen dsLleOcdMot0cahnormotimnaiatlovcgroeanmcfeonrtroGaft0R.i0E0o0En5 R!mpmLof0H.-2240766m5/. lTh.espmiekaesudrdeodsing concentrationofth representativeformulation is 0211 mg/mL. --_ Figure 31: RefporrmeuslnaitaiionvedLlOeIdMS0cnhormoimnaatlocgornacmenftorratih on of0.0E 005 mg] /mL.ofH-02.4270665m.g/TmheL msepaesudreddosing concentration of th representative formulation is 0211 mg/L. - ww Bompany Sanitized. Does not contain TSCA CBI HL24768:OneGeneration Reproduction Sudyi Rats DuPont 13784 --_ TABLE 1 SUMMARY OF DOSING MIXING AND STABILITY ANALYSES Nominal: 020 Dosing Concentr2a0tion ofH24768 (mg/5mL0) Concentr3a0t.i0o61n:V2e0ri0f3ication # 0o1s%o 11.004) 75.7) n i5o) 16502) 946500) AAvveerraaggeeMPeeracseunrtedNoCmoinnael. 015951 061.593) 046563) CoeSftfaincdiaenrtdofDeVvairaitaitoino"n" 0060%01 0050%1 +0050%4 S-HoSutrabRiloiotymSTaemmppleersature 0184 150 ass 7-Day Refrigerated 0 50) 00) 012835) 018957) (1502598) n 0051551) 81096) (1s0o0t2) AAvveerrnasgeeMPeeracseuntrNeoCmoinnea.l" 00.41058) 018537) a5t15s --~ Co`eSitacnednartdoDfVeavriaitaitoino"n" 20%004 S-Hour Room Temperature" 018s 050%01 198 041%9 495 `Concent1r5at-iDoencV2e0r0i3fication 25) 0 0, || C) 60137)3 17953) a0s2t) | | " AvoraneMancursd Conc 60051175m2) 10185510) y arg AveSrtaagnedaPredrcDeenvtiaNtoimoin"nal 060.00)1 00001) 1020.103) Coefic2i6e-nJtaonf-2V0a0r4iation" 1% 1% 3% Wn 011.954) 1020000) (1500036) || Average Measured Cone." 081596) 1.09)9 88) | AveSrtaagndeaPredrcDeenvtiaNtoimoin"nal 80000)1 00)1 082)1 | Coefficient afVariation" 1% 1% 45 | a StNautimsbteicrssbinipdaroanttehseevsergheemsepseucrtievecponecerroctfsoe(imnng/t)mLv)locf.dlc sesofechdosing vel Samples held bow t oomtemperatureafr 7daysofeigen. { [BompanTyitSsanitized. Does not contain TSCA C81 H24768: OneGenerationReproduction Sudy in Rats DuPont13784 -- APPENDIX D INDIVIDUAL CLINICALIONBPS,EMRAVLATEIROANTSSAND MORTALITY DATA | | | --~ { ie -- | Tompany Sanitized. Doesnotcontain TSCA CBI 24768: OneGeneration Reproduction Study in Rats DuPont13784 ~ nm REPRODUCTIVE AND PERFILITY EPYECTS WITH H-24768 (-]INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA IN PL YALE RATS GROVE: 1-0 CONCENTRATION: 0 MG/KG/DAY romp ovsmTIONn rCionSsmevEoDy 1aassETRvoEnDy 1 xSoACaRImFoICwEnDuBrYeDsESIsGeNrsToErSeTy DAY 96 2 wSoACRmIvFoImCEaDw.r5rieDsESIeGrNeTcEStT DAY 96 3 EwoRcaRmIrviocmEaDwrBrYreDsRsoteorNeTcETSET> DAY 96 4 SxoACaRImFvIoCnEmDuBnYisDsESIoeGrNsToErSaT> DAY 96 soSACaRImFwIuCEoDurBmYsDsRSIoeGrNsoTrEsSsT DAY 96 5 mSAoCrRsIcFrIaCEDsoBmY: rDBoSIwGNpTaEsST)DAY 96 7 SuoACaRImFvIoCEnDauBYneDsESoIeGmNsTcErSeTn DAY 96 & TTcEeoEuTmoHmeCcprLopiorzKseEc>Dmace Leer EYE(S) RED TSAaCmRmIFIwCiEsDemBeY DESIG TEST DAY 96 5 SxoACaRImFvIoCEnDurBYmeDsRSoIeGvNsTcErSsTn DAY 96 10 wSoACARImFvIoCnEmDuBrYizDsESIeGrNeTcEtSaT DAY 96 1 wEoRCxRmEPwIoCmEmDwrBrYieDsESIpGeNrsToEnSeT DAY 96 12 EwoRCxRmIFwIoCmEmDurBrYisDsESpIGeNreTcErSeT DAY 96 13 EaAAsoCorReersceciiracaeDsBooBmmY: DFFRaeocswtEaLPATeNE(S(ST))DAY 97 50 iiass si5s &5 1=3 32 | -- . || EGpan"i ySanMized. t-- iROvT EeOntasln TSCA 21 HL24768: OneGeneration Reproduction Study in Rats DuPont 13784 ~~ a2 REPRODUCTIVE AND FERTILITY EFFECTS WITH K-24768 (di INDIVIDUAL, CLINICAL OBSERVATIONS AND MORTALITY DATA IN PL MALE RATS GROUP: 1-0 CONCENTRATION: 0 MG/KG/DAY nA NoBER ossERUATION OFBISRESTRVDEADY LOaBsStERVDEADY 1 NSoACARmIFoImCMEADLIBYTIDEESSIDEGTNECTTEESDT DAY 97 15 N`SoACARBIvFoImCMEADLIBTYIEDSESIDEGTNECTTEESDT DAY 97 16 SNoACARBIFNIOCREGDLIBTYIEDSESIDGENTECTTEESDT DAY 97 17 NSoACARmIFNIOCmEGDLIBTYIEDSESIDGENTETCETSETD DAY 97 18 N`SoACARBINFOIRCMEADLIBYTIEDSESDIEGTNECTTEESDT DAY 37 15 NSoACRAIBFNIOCREMDALIBTYIEDSESIDEGTNECTTEESDT DAY 97 20 NSoACARmIFNIOCMEmDLIBTYIEDSESDIEGTNECTETSETD DAY 97 2 NSoACRAIBFNIOCREMDALIBYTIDEESSIDEGTNECTTEESDT DAY 97 2 NSoACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 97 23 NSAoCRAIBFwIoCmEGDLIBTYIEDSESIDGENTETCETSETD DAY 97 20 SNoACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 97 -- - Tis CompanySanitized.Doesnotcontain TSCACBI H-24768: OneGenerationReproductionStudyin Rats DuPont13784 ~ 5s 206s REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 (-- CLINICAL OBSERVATIONS AND MORTALITY DATA IN P1 MALE RATS GROUP: III-0 CONCENTRATION: 1 HO/KO/DAY nou wwe onservaTION FcIoRsSETRvDEADY LGaBsStERDVaEyD 25 SwoACARIBFwIRCGEWDIBTYIEDSESIDEGTNETCETSETD DAY 96 26 NSoACARBINPOIRCMEADLIBTYIEDSESIDEGTNETCETSETD DAY 96 27 wSAoCRaImFoImCmEuDrBTYiEDsESDIEGTNECTTEESDT DAY 96 28 SwoACARImFwIoCmEmDLIBTYIEDSESpIEGtNETCETSETD DAY 36 25 SwoACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 96 3 NSoACRAIBFOIRCGELDIBTYIEDSESDIEGTNECTTEESDT DAY 96 --~ 51 SNoACARImFOImCGELDIBTYIEDSESIDEGTNETCETSETD DAY 96 32 NSoACARBIFNIOCREGDLIBTYIEDSESIDGENTETCETSETD DAY 96 33 AALoOPEEcCIaA sBOoTmH FFRROONNTT LP5AG((SS)) AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT F1A2MG((SS)) SACRIFICED BY DESIGN TEST DAY 56 36 SwoACARmIFvIoCREmDLIBTYIEDSESIDGENTETCETSETD DAY 96 35 MSA0CRAIBFOIRCUEDLIBTYIEDSESIDEGTNETCETSETD DAY 96 36 SNoACARImPoImCeEwDrBrYieDsESIpGeNrsTcErSeTD DAY 96 31 wSoACARImPOIRCGELDIBTYIEDSESIDEGTNETCETSETD DAY 97 115 2288 25 %% | || "me BompanySanitized.Doesnotcontain TscA car H24768: One-Genersion Reproduction Study inRats DuPont13784 ~~ 2c REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 [i] INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA TN PI MALE RATS GROUP: II1-0 CONCENIRATION: 1 MG/KG/DAY ANDIAL WOMBER opseRvATION OFIBRSSETRVEDDAY O1BASSETRVDEADY 38 xSoACRAImFwIoCREmDLIBTYIEDSESIpeGrNeTcETSETD DAY $7 39 SNoACARBIFWIRCWEADLIBTYIEDSESIDEGTNETCETSETD DAY 57 4 ASLAOCPREICFIIACEDBOTBHY FDERSOINGTNPATNE(SST) DAY 97 41 SwoACmRIvPoImCmELDIBTYIEDSESIpeGrNECTTEESDT DAY 97 42 SwoACaRmIFvIoCmEmDurBtYiEDsESIpeGrNaTcErSaTD DAY 57 4 SNoACARBIFWIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 97 --~ 4 wSoACARImPoIRCGELDIBTYIEDSESIDEGTNETCETSETD DAY 97 4s SwoACaRmIFvIoCmEmDurBTYiEDsESIpeGTNeTcETSETD DAY $7 4 wSoACARBINFOIRCMEADLIBYTIEDSESDIEGTNECTTESETD DAY 97 47 NSOACARIBFOIRCGELDIBTYIEDSESIDEGTNETCETSETD DAY 97 @ SwoACARImFoImCeELDIBTYIEDSESIDEGTNETCETSETD DAY 97 2 2 -- "me ompanySanitized.Does notcontain Tsca cay H:24768: OGneeneration Reproduction Study in Rats DuPont13784 --_ ns 20768 REPRODUCTIVE AND FERRILITY ZFPBCTS WITH H-24768 (--] INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA IN P1 MALE RAIS GROUP: V-0 CONCENTRATION: 10 MO/KG/DAY nos wom ossmmvaTION CPhrsmETvEoDny aGsoesmvoeaDr = - 49 SnoRCaRImFoImCmEuDrBnYizDsESIdeGrNeTcErSsTn DAY 96 50 StoACaRImFoImCmEuDrBnYizDsESIpeGmNsToErSsTo DAY 96 51 tSoACaRImFoImCEmDurBYiaDsESIpGeNrsToEnSeT DAY 96 52 cpEAorCRmoIPspICrEpDrisaBcYmwDcEeSIGLNerTESsTvE(DsA)Y RED 96 $3 SwAoCRAImFIvCoEwD.auBYmeDsESIpGeNecTrEeSyT DAY 96 56 vSoACaRImFoImCEmDurBYizDsESIeGsNcTrEaSyT DAY 96 55 SwoACaRImFwIoCmEaDuBrYmspsRSIeGeN TcEtST DAY 96 6 mEXoCrRmzoenicDsoBmY DrEoSIrGNmTaEsST) DAY 96 $7 wSoACaRImFoImCEmDurBiYzDsESIpGeNsTcESrT DAY 96 ss sOSAmLCaORnRIEEF>DICDEcIDaScCBsYHmAoRDaEGmSEoIGPRNEENDITSBSRTEDBAY 96 $9 tSAoCRaImFoImCEmDumBYiEDsESIpGeN TeESrT DAY 96 sSoAnCsRIvFIeCeErDoBvY rDEmSIoGiNs)TEST DAY 96 6 vSoicaRrmeoimcmeuDrortisDsESpIGeNre$cErSa% DAY 7 . 133 1E5S 2 s6 &= 2FS os 56 i | CompanySanitized. Do note conts ainTSCA C51 H:24768: One-Generation Reproduction Study in Rats DuPont-13784 ~~ Hje i REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 [ ,INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA IN P1 MALE RATS GROUP: V-0 CONCENTRATION: 10 MG/KG/DAY ANTAL NUMBER OBSERVATION OFIBRSSETRVDEADY OLBASSETRDVAEYD 6 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT LPEAGW((SS)) SACRIFICED BY DESIGN TEST DAY 97 288 9977 6 NSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 97 a NSOACARBINFOIRCMEDALIBTYIEDSESIDGENTETCETSETD DAY 97 65 `NSOACARBINFOIRCMEADLBIYTIDEESSIDEGTNETCETSETD DAY 97 66 SNOACARBINFOIRCMEADLIBTYIEDSESIDEGTNECTTEESDT DAY 97 6 TCEOELTOHRECDRODOIKSECDHARGE RIGHT EYE(S) RED SACRIFICED BY DESIGN TEST DAY 97 85 5 975 ~ 6s `NSOACARBINFOIRCMEADLBITYIDEESSIDEGTNECTTEESDT DAY 97 6 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 87 Kd NSOACARBINFOIRCMEDALIBTYIEDSESIDGENTETCETSETD DAY 97 n SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 97 2 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 97 S1s`CompanySanitized. Do note conts ain TSCA CBI 24768: One.Generation Reproduction Study in Rats DuPont13784 ~ 50 20760 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-20768 [a]. CLINICAL OBSERVATIONS AND MORTALITY DTA IN P1 MALE RATS GROUZ: VITO CONCENTRATION: 25 MG/KG/DAY uno mE onszruaTIon soBismEsRvEpDay LGapsseERoVaEyD 73 ASLAoCvREICFIICAEDBOTBHY DFREOSNITGNPTAEHSST)DAY 56 74 NSoACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 56 75 SvoACARmIFvIoCREGDLIBTYIEDSESDIEGTNECTTEESDT DAY 96 76 mSoACaRImFoInCEeDurBnYzDsESIoGeNTETcETSET DAY 96 7 wSoACaRImFoImCoEuDrBrYizDsESIsGeNrTaEcSeE DAY 96 76 NSoACRAImFoImCmEuDrBmYIEDsESDIEGTNETCETSETD DAY 96 ~ 79 SNOACARBINFOIRCMEADLIBTYIDEESSIDEGTNETCETSETD DAY 96 80 mSoACaRImFoIwCaEuDrBTYizDsESIoeGrNecTTEESDT DAY 96 81 vSAoCRaImFoImCeEuDsBrYieDsESIoGeNmeTcErSaT DAY 96 SwoACaRImFIoCmEDaBuYeDsESpIGeNmTeEcSaT DAY 96 SnoACaRImPvIoCmEmDuBiYmeDsESIpGeN eTErST DAY 96 8 ASAoCvREIcFIIACEDsoBmY DFERSOINGTNPTAEM(SST)DAY 56 6 SvoACARImFoIRCEELDIBTYIEDSESDIEGTNETCETSETD DAY 57 6 tSAoCReIvFoImCmEuDrBmYizDsESIpGeNecTrEeSpT DAY 97 5 @ 3 56 | _-- || CompanySanitized.Doesnot containTSCACi! HL24768: OneGeneration Reproduction StudyinRats DuPont13784 --_ ue 26768 7 REPRODUCTIVE AND FERFILITY BEFECTS WITH H-24760 [i "INDIVIDU CLINICAL OBSERVATIONS AND MORTALITY DATA IN B1 MALE RATS GROUP: VII CONCENTRATION: 25 MO/KG/DAY mo, ome onsmvaTIOn OPmossEtRVEoDar tGaRsSeERoVaErD SwoACxRmIFwIoCmEmDurBrYizDsESIpGeNecTrEaSyT DAY 97 8 SwoACARImFoICmEmDuBiYEDsESIpGeNveTcErSeT DAY 97 8 tSoACaRImFoImCmEuDrBrYizDsRSIpGmNaToEmS>T DAY 97 5 xSoACaRImFoImCmEuDrBnYisDsESIpGeNmsTEcSrT DAY 97 a sSaocmRrmriacmeD oY pestax TEST DAY 97 52 EwoXCxRmIPwIoCmEmDurBrYieDsESIeGrNeTcEtSaT DAY 97 ~ 5 wSoACaRImFoImCmEwDr5rvinDsESIpGeNmeTcErSaT DAY 97 soSACARImFoImCmEuDrBrYizDsESpIGeNecTrEaSyT DAY 97 55 SwoACaRImPoImCgEwDrBryiEDsRSIpGeNveTcErSaT DAY 97 5 NSoACaRImFoImCsEwDr5mvizDsESpIeGrNsToErSsTn DAY 97 7 os | -- . Ti CompanySanltized. Does not contain TsGA + 124768:OneGeneration Reproduction Study in Rats Dupont13784 _ APPENDIX E INDIVIDUAL CLINICAL OBSERVATIONS INP; FEMALE RATS DURING PREMATING | | | -- me | `Company Sanitized. DonotscontsainTSCA Ct HL24768:OneGeneration Reproduction Study in Rats DuPont13784 ~~ INDIVIDUAL CLINICAL OBSERVATIONS IN P, FEMALE RATS DURING PREMATING EXPLANATORY NOTES Notes TestDay7l = Lastdayofpremating period that data were recorded. | | |i | | 1 -- Company Sanitized. DossnotcontainTSCA og 24768:One.Generation Reproduction Study in Rats DuPont-13784 ~~ 51 20768 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 [o] CLINICAL OBSERVATIONS IN 21 FEMALE RATS DURING PRENATING GROUP: X10 DOSE: 0 MG/KG/DAY mo we opsxuaTIOn PCrBmSsETRVEDDay LOBaSsEtRVDaEyD 57 No ABNORMALITIES DETECTED 98 No ABNORMALITIES DEFECTED 95 NO ABNORMALITIES DETECTED 100 No ABNORMALITIES DETECTED 101 NO ASNORMALITIES DETECTED 102 NO ABNORMALITIES DETECTED 103 NO ABNORMALITIES DETECTED 104 aAuLoOpPsEcCIrAn ALOPECIA BpOmTHmvFREONT BOTH FRONT LPEAGR((SS)) --_ 105 No ABORGALITIES DETECTED 106 oScpanecanmerchmst 107 AAALLLOOOPPPEEECCCIIIAAA BBROIOTGTHHHTFFKRRIOONNNDPT BLQAEUNGA((RSST))ERS 1365 50 n7 7 77n" n7 155 n7 n n 108 NO ABNORMALITIES DETECTED 108 AAuLoOPPEECCIIAA BBOOTTHH FFRROONNTT PLAEWG((SS)) s5 2Bd 10 AuoPECIA RIGHT FRONT LEO(S) 1m xo ABNORMALITIES DETECTED s6 m2 vo ABORGLITIES DETECTED + 1m vo AmomeuITIES DETECTED - 1m No AmORGALITIES DESECTED | | --- . | T0- | CompanySanitized. Donotecontsain TSCA cB H:24768: OneGeneration Reproduction StudyinRats DuPont 13784 ~~ 50 24766 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 [-- INDIVIDUAL CLINICAL OBSERVATIONS IN PL FEMALE RATS DURING PRENATING GROUP: 11-0 DOSE: 0 MG/KG/DAY ANTAL NowBER opsRvaATION OFBISRESRTVEDDAY O1BSSTERDVAEYD 115 NO ABNORMALITIES DETECTED 16 NO ABNORMALITIES DETECTED 17 No ABNORMALITIES DETECTED 18 No ABNORMALITIES DETECTED 119 ALOPECIA BOTH FRONT EAW(S) 120 RALLOOPPEECCIIAA LBEOFTTH FFRROONNTT LPEAGM((SS)) 2 28 52 7a --~ BI: CompanySanitized.Deesnotcontain TSCA CRI H-24768: One-Generation Reproduction Study in Rats DuPont 13784 --_ i i REPRODUCTIVE AND PERTILITY EFFECTS WITH -20768 [i J CLINICAL OBSERVATIONS IN P1 FEMALE RATS DURING PRENATING GROUP: IV-0 DOSE: 1 MG/KG/DAY DOL NBER oBsERvaTION FCIBRSSETRVDEADY LGABSSTERDVAEYD 121 No ABNORMALITIES DETECTED 12 Fo ABNORMALITIES DETECTED 123 vo ABORGLITIES DETECTED 124 vo AmoRMLITIES DETECTED 125 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT 1P8AGN((5S)) 126 No ABYORMALITIES DETECTED 127 No ABNORMALITIES DETECTED 125 xo ABNORMALITIES DETECTED 129 AAuLoOPPEECCIIAA BBOOTTH FFRROONNTT BLAEWG((SS)) ~~ 10 NO ABNORMALITIES DETECTED 11 Ko ABNORMALITIES DETECTED 12 No ABWRMALITIES DETECTED 13 No ABWRMALITIES DETECTED 134 AAALLLOOOPPPEEECCCIIIAAA BBBOOOTTTHHH FFFRRROOONNNTTT PLLEEAGGWI(((5S3))) AALLOOPPEECCIIAA LBEOFTTH FKRIONNDTQUEAAWR(TSE)RS 135 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT LPEAOW((SS)) 136 NO ABMORMALITIES DEFECTED 137 to AmoRGLITIES DETECTED 220 7n 1550 nn n33 37ss 77 77 s5 7n . ~~ - -= `Company Santized. Do fote conts aln TSCA BBY H2785:OmCouration Bevo inSIRE eee JPPOAIH --~ 5s i REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 f JINDIVIDUAL CLINICAL OBSERVATIONS IN P1 PEALE RATS DURING PRENATING Grove: 1-0 DOSE: 1 MG/KG/DAY preter onseRvaTION FOIBRSSETRVDEADY LOABSSTERVDEADY 138 vo AmwoRGLITIES DETECTED 135 No AmNORMMLITIES DETECTED 140 AwOoRrBsCeInN rLEiFcTerHFINrDowQULAERST(ESR)S 11 vo AmomwurTIzs peTEcTED 142 to AmouaurTres oerecres 143 ro AmwomsurTres oerecTe> 144 ro AmomsurTIEs DErEoTED nn nn Ee Eompany Sanitized. Does not contain TSCA cat HE24768: OneGenerstionReproduction Studyin ats Dupont13784 --_ us 2760 REFRODUCTIVE AMD FERTILITY EFFECTS WITH B-20766 [-- INDIVIDUAL CLINICAL OBSERVATIONS IN P1 FEMALE RATS DURING PREMHTING Grove: vI-0 hose: 10 Me/KG/oRY uno, yom onssRvaTION PCxomsoernieosxy asotpsomaDr 1s vo amowaurTizs DereoTED 16 aAAuooorrrssscccizina sooommm mmmooovvvee: 1Fea0on(((3ss))) AAoorrsacciin onomm mmoowv:: FLaEn0((s3)) 1 wo mwousuzTiss DersoTED 1s afuoorssots cums 1s oNaororRpecscIcmAna spLaooemmr mFFRRoOONNwTT LPEBAnGN(i(9S))) orscin [ae FRONT L0(S) --~ 10 aosrosrsceirna spoomm mFRoowwT mLRsG()S) 151 Nmorrsccimaa ssoomm FmRoovwe LBRn((8s)) 152 vo mvonourTiEs SErReTED 155 wo amsommurnins DemseTID 150 wo amonmurmies DETECTED 155 wo amonmuIniEs DETRCTED 156 wo amommurTIzs DETECTED 157 vo amvonouzTiEs oerseTED 15 wo asvomwsInIEs DETICTID 159 Wo amcrmurrres oeTecTED 60 wo swonmLrmiss DerecTED 52E%S 34se 2un aa "5 5 2i%a 35ii .: 77 a "i - | 14s | CompanySanitized. Doss notcontain TSCACB! H24768: One-Generation ReproductionStyinRats DuPont13784 ~ 5s 2768 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 [o--] CLINICAL GRSERVATIONS TN PL FEMALE RATS DURING BRENATING GROUP: VI-0 DOSE: 10 MO/KG/DAY ANDHAL NUMBER onsErvATION OPBISEsRVDEaDy LOBaSsEtRVDEaDy 161 No ASNORMALITIES DETECTED 162 No AENORMALITIES DETECTED 16 No ABWORGLITISS DETECTED 166 No ABWORMALITIES DETECTED 165 AALPOEPECCIIAA BBOOTTHH FFRROONNTT PLBA0((SS)) 165 NO ABNORMALITIES DETECTED 167 No ABNORMALITIES DETECTED 168 NO ABNORMALITIES DETECTED 228 apH ~~ --~ . TiC `EompanySanilized.DossnotcontainTSCACBI "H-24768: One-Generaon Reproduction Study in Rats Dupont13784 ~ 20750 REPRODUCTIVE AND FERTILITY SPPRCTS WITH K-24760 I. CLINICAL OBSERVATIONS TN 71 FEMALE RATS DURING PREKATING Rove: viz-o Doss: 25 MG/KG/DAY amos woe r-- sCiasseoar LGaaseemDvAeYD 165 wo AmwoRMLITIES DETECTED 17 wo ARwoRMmITIES DETECTED 1m ro amommurrizs oevecrED 12 worse poms Frou PANS) 1 vo mommurTIss DETECTED 174 aAMlooorpreececzitaa sooommm:: rRRooovvEee LLpBaa0ow((sSS))) 175 nAuoorraecciena Bsoomm mFRoONwT LpEaGw((5s)) 176 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT LPEAGN((sS)) --_ AAALOBOrrEaaEccCIiIAaA BoPOETmRHTFPERRMOOVNET ELAEAG((SS)) 1 wo AmwommLITISS DETECTED 17 wo AmvoRmLITIZS DETECTED 1 No AmvommLrTEs DemacTED 160 No mvormrnrss petacTED . @ n &s: na5 s5s nn 251 5Sa0 && aa ' 181 NO ABNORMALITIES DETECTED 192 asosscra som FRONT PANS) 199 no amommureIzs peTsoTED | 184 wo amvomgwrTiEs peToTED 105 wo asvoumsrres oevecrsn 2 n --_ . He `Company Sanitized. Doesnotcontain TSCA CBI - i Aries Oo coe ginn.om mme ammri LnnnoooonmrrrmmmmmI nome wr sm Lo - || ~ ges H24768: OneGenerstion Reproduction Study in Rats Dupont13784 -- APPENDIX F INDIVIDUAL CLINICAL OBSERVATIONS IN P; FEMALE RATS DURING GESTATION | || --~ = --- Company Santized. Doesnot contain TSCA CE H24768: OneGeneration Reproduction Sudy in Rats DuPont13784 ~ INDIVIDUAL CLINICAL OBSERVATIONS IN P, FEMALE RATS DURING GESTATION EXPLANATORY NOTES Note `This Appendix contains data from females with evidence of copulation observed. -- | 1 Tm { "Company Sanitized,Does notcontainTSCACL H24768: OneGeneration Reproduction Study in Rats Dupon-13784 ~~ se 20760) REPRODUCTIVE AND FERTILITY EFPECTS WITH H-20768 IL INDIVIDUAL CLINICAL OBSERVATIONS IN Pl FEMALE RATS DURING GESTATION GROUP: T1-0 DOSE: 0 MG/KG/DAY amos vomER oBsERVATION FOIBRSSETRVEDDAY OLBaSsE?RVDEaDy 97 vaoma mus ss sem postive 95 sem rostIve 100 sem soszmve 101 sem roszrve 102 seam sostrrve 105 seems sostTve 104 AAsLoOpPEEcCIIAA pBOETRHmFNREONT L3G(5) ASeLRORTMECIpoASTBTOITVHE,FRONT EAW(S) 105 seem sosTIvE 105 AScoarbmcCmHaESTcust Sem postive 107 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT PLAEWG((S5)) SALeOePrECIrAosRtIIGIHvTE HIND QUARTZRS 108 sem zostmve 105 sALeOPmECIsAosRtImGiHvTe FRONT LEG(S) m0 sem sosrTive 1m sem wostTIvE nz ven mos o o o o o o 0 o o o o o0 22 o ao o o o 2os 0o 221 o0 2o o o 7 2o 0 0 0 I o Trao- i `CompanySanitized.Does notcontainTSCACBI 24768: OneGenerationReproduStcudtyiinRoatns Dupont 13784 --_ a 20750 REPRODOCTIVE AND FERTILITY ZRFECTS WITH H-24768 (--]INDIVIDUAL CLINICAL OBSERVATIONS IN Pi FEMALE RATS DURING GESTATION Rove: 11-0 Doss: 0 Mo/KG/DAY prTp-- onsemzion CFIoRcSmTmvDEADY LCaas?senady Ww vemos mo 1m sem sosirive ns som postive ns vaemow mu 17 sem sosimrve 16 sem ostrive 1s spe sosinve o o o o o o o o o -- i |~ : |{ r -- e------Tha-- is eit-- ---- -- ---- e | Company Sanitized. Does not contain Tsca ca HL24768:One Generation Reproduction StuinRdatys Dupont13784 ~~ 2065 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 TNDIVIDUAL CLINICAL OBSERVATIONS IN Pl PEALE RATS DURING GESTATION GROUP: Iv-0 DOSE: 1 Me/KG/DAY Ano, omer onseRvaTION 121 sem rostrve 122 ses rostrIve 123 vALaOmPEoCsIAm30uTH FRONT. PAN(S) 124 sem wostTIve 125 AAVALLGOOIPPNEEACCLIIAABBBLOOOTTGHH FPRROONNTE LE2A0A((8S)) 126 sem sostTve 1 sem sostrve 128 sem rosteve ~~ 129 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT PLAEMG((SS)) VAGINAL PLOG 130 aon EG 31 vaom mus 12 sKLeOVmECTpAosBtOiTvHeTROVE 2AH(S) 133 vaonws moe 136 aALuOoPpEECcIIAA pBOoTmH RFROOVNET LPEAGN((SS)) 'ASNLPOOEPPREMECCIIPAAOSBILATESIFEVTEHTIAINLD QUARTERS - 135 'ANuOoBpEECCIIAA BSOTTHH FFRROONNTT PLNENG((SS)) ASLPOEPRMECIPAOSBIATCIKVE OFIsRsSETRVDEADY LGABSSTERDVAEYD o o o o 07 pi0 00 o 22 o 0 0 o o o0 0 221 o o o o 0 20 2o o o 00 22 0 2o 7 2 0 o 22 o : 1 2 . | Sr------Tre as e-- ens---- --e PompanySenftized.DossnotcontainTSCA CB] BH2247668OGnneeeGreinoinReproducttiioonn SSuddyninRaRtass__ DDuubpoone1i3s7i8s4e ~ mau RERONUCTIVE AD PERRILITY EPPBCTS WITH H-24768 [--]NDIVIDONL CLINICAL OBSERVATIONS I 71 FEAALE RATS BORING GESTATION amour: 1-0 pose: 3 workosma awn, wna [re-- FSumenoar Bagoe meay ne vacow move NE ---- 1 sem rosie 1s seam vostve TE raahgogi a g-- h) [TA -- [A ---- 10 srw vos p Ww viens ma .o o. .. .o .:; na3 0o o. .0 o. ~~ - | | ; Tae [BompanySenitizod.Doesnotcontain Tscacer 120768: One.Generation ReprodSutucdtyiinRoatns DuPont13784 ~ ut 2006s REPRODUCTIVE AD FERTILITY EFFECTS WITH H-24766 [--. CLINICAL OBSERVATIONS TN P1 FENALS RATS DURING GESTATION Gov: vi-o poss: 10 e/xa/ony aL some ossemazon 1s sem postrive 146 AaSovtroeasmcsicsxaosrsseoormmverFRoONwT 1n8iG(s5)) 16 aSveosmscrpaosaiTmIvoen 109 NaSLstOoErnEsCeIrrNaoLssEaiFvTenmFRoONwT pL8a0n(s5)) RRioorrmaeenonn ssoommi: aoww a2(0(S3)) 150 aRSsoiormresCeipraosisBaoormmismForwo pLEaGnSs)) 12 wom moo 1 von ro 156 sem postrive 155 seme sosimive 15 spe sostive 157 sem posimive se som sosmive 10 sem sostorve 161 seem sosimive 102 sem soszrve 10 vem nus CPraesteosny arsetmnovadr : a2a n oo0 23: i2 ai o:a 2io o o o o o o o o . o o || se --e----------------s-- por r----e ------em || - 144. | BompanySaniized.Doesnotcontain TSCA Cat H24768:OneGeneration Reproduction Sudy in Rats Dupont13784 ~ xt 20768 REPRODUCTIVE AND FERTILITY BEPECTS WITH 124760 [--.... CLINICAL GBSERVATIONS TN FI FEMALE RATS DURING GESTATION GROVE: VI-0 DOSE: 10 Mo/KG/oAY am wom onsrrIon 165 seme soszrrve 166 sem posmve 169 sem ostrive 160 seme soszrrve CFoISRESRTVOEMDY LoamsstEaDvAeYD o EN || . -- Tw {Bompany sanitized. Does not contain TSCA CH: H24768: OneGeneration Reproduction StudyiRats DuPont 13784 -- i ii REPRODUCTIVE AND FERTILITY EPPECTS WITH H-24768 [ lINDIVIDUAL CLINICAL OBSERVATIONS IN PI FEMALE RATS DURING GESTATION GROUP: VIII-0 DOSE: 25 MG/KG/DAY uns wmER opsERvATION CiomsnsvEDDa.v LGaaseemmDvaavD 165 sem rostrve mo aon me m1 sem sostrrve 172 AajLorOerPsEscCiiIcaAhBsgOoyTmH FRONT FRONT BAN(S) LEG(S) MOPECIA Bom STOR(S) wm sem sosrrve 16 aASLuoOoEmsRcCiIPaAOSIsBTooImmVEsFRoOuNrT 1s2a6w.s8)) --_ 175 VaAAsLGoOIePNsEAcCLiIaA7sB1Oo6TmH FFRRoONwTs LPEAGH((SS)) ALOPECIA LEFT SIDE(S) 16 AAALLuOOoPPmEEcCCiIIaAA pBBOOTTeHHnFFRReOONNTT 1Z2A3N.(8S)) Sear oSTTIVE, 177 sem rostrve 18 sem roszmve 180 seme rostTIvE 101 sem rostrve 195 sem rostrve 165 seme sostrIve 18 ASLeoRpRmciPaOSsIoTmI:VERow PAM(S) o o o 7 22g u a o 2a0 5oo 2ao u 2 o 222 . 0 o o o o o o o o .o o o 20 --~ . . | | | "146 | Company.`Sanitized.xDoes notcontTSaCAicny H:24768: One-Generation ReprodSutucdytiinRoatns DuPont13784 poo st 24760 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 [--] `CLINICAL OBSERVATIONS IN P1 FEMALE RATS DURING GESTATION GROUP: VITI-0 DOSE: 25 MG/KG/DAY ADA OBER oBsERvATION OFBISRESRTVDEADY OLBASSETRVDEADY 187 SALeOEPRECIPAOSIBTOITVHEFRONT BAW(S) 19 sem soszrIve 190 AvLaOePnEmCLIAmRuIGHT FRONT LEG(S) 190 sem postive 12 semw postTIve 1 1o zno o o --~ | --- he CompanySanitized.Does notcontain TSCA CB! H24768: OneGenenstion Reproduction StudyinRats Dupont13784 --_ APPENDIX G INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA IN P; FEMALE RATS DURING LACTATION || | | | | | 5 | Company Sanitized.Doesnot contain TSCA C5! 24768:OneGeneration Reproduction Study in Rats DuPont13784 ~ INDIVIDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA IN P; FEMALE RATS DURING LACTATION EXPLANATORY NOTES Note Test days for animal fates are determined from the initiation of test substance administration, designated as Day 1 of test. -- --~ - ws Company Sanitized. Doesnotcontain TSCA CBI H-24768: OneGeneration Reproduction Study in Rats DuPont13764 --~ 50 24768 1 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 ([DUAL CLINICAL OBSERVATIONS AND MORTALITY DATA IN PL FEMALE RATS DURING LACTATION GROUP: 11-0 DOSE: 0 MG/KG/DAY Anos yoEsR, oBsERvATION FOIBRSSETRVDEADY LOABSSTERVDAEYD $7 SNoACARBINPOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 101 9% SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 110 95 SNOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 102 100 SNOACARBINFOIRCMEADLIBYTIEDSESIDGENTECTTEESDT DAY 106 101 NSoACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 101 102 CSOALCORRIEFDICDEIDSCBHYARDGEESIVGANGITNEASLT ODPAEYNI1N01G RED o 4. --~ 103 SNoACARBINFOIRCMEADLIBTYIEDSESIDEGTNETCETSETD DAY 102 106 AaLuOoPveECcIIAa BpOETRHINFERUOMNT LEG(S) ASLAOCPREICFIICAEDBOBTYH FDERSOINGTNPTAE(SST) DAY 103 0 a: : 105 XSOACARBINFOIRCMEADLIBTYIEDSESDIEGTNECTTEESDT DAY 104 106 AAuLoOePEsCcIrAa cBhOeTsHtFRONT BAW(S) SAALCORPIEFCIICAEDBOTBHY DFERSOINTGNLETGE(SST)DAY 100 I0 4 a 3 3 108 MS0ACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 101 . 109 ASLAOCPREICFIIACEDRIBGYHTDFERSOINGTN LTEEGS(TS)DAY-101 0 a . 10 SwoACARSIFNIOCREMDLIBTYIEDSESIDEGTNETCETSETD DAY 103 - . | "150- DompanySanitized.DonotecontsainTCA 21 H:24768: OneGeneration Reproduction Study in Rats DuPont 13784 ~~ se 20768 7 REPRODUCTIVE AND FERFILITY BSFECTS WITH H-24768 [--! CLINICAL OBSERVATIONS AND MORTALITY DATA IN P1 FEMALE RATS DURING LACTATION GROUP: 3-0 DOSE: 0 MG/KG/DAY ANDL NuMBER OBSERVATION OFIBRSSETRVEDDAY OLBASSETRVDEADY 12 SmoACRAImFvIoCmEmDwrBTYIEDsESIDEGTNETCETSETD DAY 104 113 NSoACARsIwFoIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 100 16 SNoACRAImFvIoCmEmDwIBTYIEDSESDIEGTNETCETSETD DAY 104 115 ASLAOCPREICFIICAEDBOBTHY DFERSOIWGTNEATWE(SST) DAY 103 16%SACRAIBvFoIRCMEADLIBYTIEDSESDIEGTNETCTEESDT DAY 101 17 NSoACaRsIFvIoCmEmDLIBTYISDSESIDEGTNETCETSETD DAY 101 --_ 18 SNAoCRAImFvImCMELDIBTYIEDSESIDEGTNETCETSETD DAY 103 139 `NSOACARBINFOIRCMEADLIBYTIEDSESIDGENTETCETSETD DAY 101 120. SNOACARBINFOIRCMEADLIBTYIDEESSIDEGTNETCETSETD DAY 100 --_ : -- me CompanySanitized.Doesnotcontain TSCA CBI 24768: OneGeneration Reproduction Study in Rats DuPont13784 PS (i 2060 1 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 LDUAL CLINICAL OBSERVATIONS AND MORTALITY DATA IN P1 FEMALE RATS DURING LACTATION GROUP: IV-D DOSE: 1 MG/KG/DAY An VEER onsERvaTION FOIBRSSETRVDEADY LGABSSTERDVAEYD 11 CSOALCORRIEPDECDEIDSCBHYADREGSEIVGANGITNEASLT DOPAEYNI1N0G2 RED o 1m SNAoCARImFoIRCMEDITBIYEDSESIDEGTNETCETSETD DAY 102 123 ASAoCpREICFIIACEDBOTBHY DFREOSNITGNZATWE(SST) DAY 100 o s 120 NSOACARBIYFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 100 125 AALLOOPPEECCIIAA BBOOTTHH FPRROONVTE LPBAGR((SS)) SACRIFICED BY DESIGN TEST DAY 101 0o aa 126%SACRAImFoImCmELDIBTYIEDSESIDEGTNETCETSETD DAY 103 -- 128 SNoRCARImFOImCEGDIT3IvEDSESIDEGTNETCETSETD DAY 103 129 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT LPEAOW((SS)) SACRIFICED BY DESIGN TEST DAY 103 o 4i 130 NSAoCRAImFvIoCmEmDLIBTYIEDSESIDEGTNETCETSETD DAY 101 11 SwoACARImFoIRCmEwDrBnYisDsESIpGeNtTeESrT DAY 100 12 SAALCoRPIEFCIICAEDBOTBHY DFREOSNITGNPTAEW(SST)DAY 103 o ` 1m NSAoCRmIvPoIRCmEwDIBTYIzDsESDIeGvNeTcETSETD DAY 103 136 nALoOePEECCIIAA oBOHTH FFRROONNTT LEBAGW((SS)) - AALLOOPREBCCIIAR L2E5FkT FTIANIDL QUARTERS SACRIFICED BY DESIGN TEST DAY 101 00 43 0 ai | --_ . | -- Tm -- | `Bompany Saniized Boas notcontainTSCA Cot H24768: OneGeneration ReproductionSudy inRats Dupont13784 ~ [i 20060 1 REPRODOCTIVE ND FERTILITY EFFECTS WITH H-24768 - CLINICAL OBSERVATIONS AND HORTALITY DATA TN P1 PEALE RATS DURING LACTATION Grove: 1-0 nosm: 1 vasxa/oAY mos mE ossaminnzon CPramssetnvoe>a aosptsvoiaDr 135 ANaoorrosaccsiinn spsaoocmmk: Rmooww mL2n6i(es)) :: :i. SaCRTTiceD BY DesToN TEST DAY 101 136 SwoACmRIwFoImCEmDwrBYieDsRSIoOeNvTeEcSrT DAY 100 137 ScAoCRuIFmICbErDsBcYraDrRaSsIOaN sTEmST DoArYmI1i0G5 RED 15 SwoACaRImFoImCEoDwsBYieDsRSIpOeNr7s5o5n% DAY 103 1 SwoACmRIoFImCEmD wBYEDsESIoGeNrsToHrSeR DAY 100 12 SxoRCaRaIFvIoCmEaDurBeYzzbsasbineTshSoR DAY 102 ~ 1 wSoACmRIoFImCmEDuBmYsDsESIdGeNmsTcErSsT DAY 103 146 SwoACrRImFoImCEmDusBYiepsRSIpoenrTshSoR DAY 102 |~ || --_-- | Te ee Compan Senizd. Doss etcsian TsoA CE F-24768: One-Generation Reproduction Stuy in Rats DuPont.13784 -- IC 2478 ] REPRODUCTIVE AND PERTILITY EFFECTS WITH H-24768 -AL, CLINICAL OBSERVATIONS AND MORTALITY DATA IN PL FEMALE RATS DURING LACTATION GROUP: VI-0 DOSE: 10 MG/KG/DAY perp OBSERVATION OFBISRESRTVDEADY OLBASSETRVDEADY 146 AALLOOPPEECCIIAA BBOOTTHH FFRROONWTTPLAEWG((SS)) `SACRIFICED BY DESIGN TEST DAY 102 18 AALoOpPEEcCIIAA ACHBEDSOTMEN SACRIFICED BY DESIGN TEST DAY 102 149 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT PLAEWG((SS)) SACRIFICED BY DESIGN TEST DAY 101 150 AALLOOPPEECCIIAA BBOOTTHH FFRROONNTT LPEAGW((SS)) SACRIFICED BY DESIGN TEST DAY 101 152 ASLACoREICPIIACEDRIBGYHTDESSIDIEG(NS)TEST DAY 103 ~~ 153 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTECTTEESDT DAY 103 156 N`SoACAREINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 103 155 SNoACARBINFOIRCMEDALIBTYIDEESSIDEGTNE7C2TSETD DAY 101 15 SNOACARBINFOIRCMEADLIBTYIEDSESIDEGTNECTTEESDT DAY 102 155 N`SOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 101 159 SNOACARBINFOIRCMEDALIBTYIDEESSIDEGTNECTTEESDT DAY 101 160 * NSoACARBINFOIRCMEADLIBTYIEDSESIDGENTETCETSETD DAY 101 | 161 NSoACARImFOIRCWEADLIBTYIEDSESIDEGTNECTTEESDT DAY 103 0 h o 43 oo s: 0 1a. . a . ~ . Iss Company Sanitized. Doesnot contain TSCACB 124768: One-Generation Reproduction Sady inRats Dupont13784 --_ a 2078 `REPRODUCTIVE AND FERTILITY EFFECTS WITH H-20768 [-...... OBSERVATIONS AND MORFALITY DATA IN P1 PEALE RATS DURING LACTATION GROUP: vI-0 pose: 10 wo/xa/oaY no, women onsevaTION CFoissmtvEoDav acsmeseanvvD 1 0SACRaImFoImCpEuDrBmYisbsESidaeNrsoTErSe?> DAY 101 16 wSoACaRImFvIoCnEoDusBnYreDsESIdGeNmsTcErSeTp DAY 101 165 vSAoCRaImFvIoCmEmDwrBnYizDsESIpGeNsToESs? DAY 101 166 StoACaRImPoImCmEuDrBmYizDsESIpGeNreTcErSETD DAY 103 167 0SACRaIsPvIoCmEmDwrBnYzeDsESIdGeNrsoTrEaS>R DAY 104 19 aSAoCmRsIeFrIaCEDmeBxY DESION TEST DAY 102 ~ . a | --_ . ese --------Ts--e --e SS --------eee---- `CompanySanltized. Doesnot conTtSaCAiCBnI 12015: OeGms ms bonis ~ 1 J -------- BOL. oJOo soir co es i ms i os. woman -- FmEE me = E E CRAARETE RETTR IRT EITERER vao "w IS L a EEAE TTnRRITn IETEEEIREau wo .dio i ormo RAEbIse wer ~ wn e mEEeRnEom m EmnEuy. t: d3 wpLE RmEm aR.n a .ED . H:3E q oupY RnoEmAo mERreEmmo LE. E.goo omppn RsrEeemaTsg nIsseeRnr E wopgE E rsrmAssY R sse er we ~ : | EoroanSatz sos eon TooA cot H-24768: OneGeneration Reproduction Study in Rats Dupont-13784 Pa [i 24765 1 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 ey! CLINICAL OBSERVATIONS AND MORTALITY DATA IN P1 FEMALE RATS DURING LACTATION GROUP: VITI-0 DOSE: 25 MG/KG/DAY AL NOE oasERVATION oFsIsRESRTvDEADY LOaBsS?ERDVAEYD 182 AALLOOPPEECCIIAA LBEoFmT HFIRNODNTQUPAAWR(TSE)RS CSOALCORRIEFDICDEIDSCBHYARDGEESIVGANGITNEASLT ODPAEYNI1N02G RED o0 ai o 183 SNoACARImFOIRCMELDIBTYISDSESIDGENTECTETSETD DAY 100 185 NSoACARSINFOIRCMEADLIBYTIEDSESDIEGTNECTTEESDT DAY 103 186 SAALCORPIEFCIICAEDBoBmY DFERSONITGNPATWE(SST) DAY 100 fl 187 `xSoACARsINFoIRCwEADLIBYTIEDSESDIEGTNETCETSETD DAY 101 -- 188 NSOACARBINFOIRCMEADLIBTYIEDSESIDGENTETCTEESD DAY 101 185 NSoACARBINFOIRCMEDALIBTYIDESESDIEGTECTTEESDT DAY 101 10 NSoACARmIFOIRCWEADLIBTYIEDSESDIEGTNECTTEESDT DAY 102 191 NSoACARmIFwIRCMEADLIBTYIEDSESDIEGTNECTETSETD DAY 102 192 SNoACARBIvFoIRCMEDALIBTYIEDSESDIEGTNECTTEESDT DAY 102 | _-- ise -- | CompanySanitized. Donotecontsain TSCA C6! H24768: One.Generation Reproduction Study in Rats Dupont 13784 ~ APPENDIX H INDIVIDUAL BODY WEIGHTS OF P; MALE RATS AND MORTALITY DATA ~~ . . | | Company -158- Sanitized. Do esn otc on ta i n TSCA CBI HL24768: One-Generation Reproduction Study in Rats DuPont13784 --_ INDIVIDUAL BODY WEIGHTS OF P; MALE RATS AND MORTALITY DATA EXPLANATORY NOTES Notes TestDays 1-73 = Premating period Test Days 73-87 = Cohabitation period. Abbreviations SD = Sacrificed by design `Summary Section SD. = Standard Deviation SE. = Standard Error N= Numberin Group -- -- . | | . Te CompanySaniized. Doesnotcontain TSCA CBI 524768: OneGenersion ReproductionStyinRs Duron 13784 --_ ia ince (--) REPRODOCSIVE AND FERTILITY BFFRCTS WITH 5.24768 S00 WEIGHTS (@) OF F1 KALE RATS AND NORTALITY DATA asoup: 3-0 cos: reson alli Ds som om x ow [RI :::3 eBiReooeeowuneess MMd mesdsms8 mgmda wWomeseaa aEaBmsnooweanes :: : mmBIaOooMEDnn mom omE EmsdoW mdHnnno@E3 dind oEmmmniynoa8oEns M8i: mmMesoidondmmeeses WWomwaddl oBoBnmmieoaoEnn B m Imnoa s ii3i m mBBeeasdooRmuden3ido GMHensowmnHslm oBMmio ooomd s diBoanen Fii2] W mBeLrooomm nhens mom aHieoomWmdses mmBGielh Bmmoaitoaadnnn --_ 233n hmmmeoeosolonommenIsodmoEsnsomeEEEmndS&EE8Snds WdB mSdoomsmee ii Mweso at waCitonhMoDsatmtoa EwoOamts%oaHaWnIs wdwtcsdw sosuwws | * . EomBpaCnHySantzad.Dose otcontain TSCACR! 'H24768: One-Generaion ReproductionStudyinRats DuPont 13784 PN fi is 207s 0 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 L INDIVIDUAL BODY WEIGHTS (g) OF PL MALS RATS AND MORTALITY DATA --e-- rove:-- e1p-0ee -- DosE: -- 0 eHOt/KGp/eDrA-- eYeeteeie-- eeten onoTweeosr: x @ mom mom sons Twz en 3: w8w1rs8y Wd aBGmeeslo Bes WdGeeDae WI mseaeessd NE slBeusds BIE BsHiesds 3D 5Bi35iY.2 SoBDo roAYawe9e6) els mows 33` 3 2 BS8e00 M mMiNsS B03 ds RoM0eou0 deed 3 Hdmel amy SsmEmnEi sad Geamiesss soi saarsori mmwomrawwesse soa m own 2i5 1 a8i5ss%e eS HBMES3E G3 fGBSeiSdc drs GMdn2Sa eo dBseeseEEds)osi me ou sdseellds mmwaooawwaoene so: mow ow i3ifl i3 G85h3 OBi8miNs3 83 Mai BNeeEnsY BES sS6Io7Ns SRS sHlease Ned sSdimeon Soa smaells s ooowwweennn mle mown 011 eB5oes Se B fHmEshMmd36 GE Ged ODs1meo2e Hole Gsweeenns san Gamuiasss Bon wssieloae mooowwweennn es ow owoan ~ 22a a $s i0e5aBaiese 3 mS BBde9od3s WSaemIds WMS wmsaernx BW hlsaadh Wh a3 ssedo omeoomwwnn sh sown P52.d wWeTeiOmamh3ss sCoBEs3S sHuMSoR sWiNyds sCeWhasE shnGy?a at a7 at at A aT ow ~ . . tei || CoipanySanlized.DoesnotcontainTSCA CBI HE24768:OneGeneration Reproduction Stady in Rts Dupont13784 -- [i 20068 REERODICTIVE AND FERTILITY EFFECTS WITH H-24768 LJ!INDIVIDUAL BODY WEIGHTS (5) OF 71 MALE RATS AND MORTALITY DATA Groom: 111-0 Dose: 1 we/KG/oY offios ps wom om wa ai3i snneeeeeoer mmmaemddad moowmemndasi dWmoaesse amEHmidla am EWsssaia&oanfme 3233% mnmeeesdoaoommomESead wmodmonnn mB nGmhoo sms mEBBIgn3o@d8ossn 33i Bmdiooamaesd n EeedoE addomEnoEdeiBlIoo8E #%%3 BeTBroEordomoenand WWdweesse aaE Emmiar o mmamdsen B nBaintoa m8is3d iiii B BHMeelseooonhadmioin@mBoEwIoSS GEGoeanddn EEaENesne @Eddnnloo8 @ mnn iiii FEmFCERoARRRnG EEnR SmH eH mS C d E dR nEEe: Gn --~ i Berm 8 Wr El ms wJioE mHA0$e E3sD4aes eaCtmEoS osuCamms auaotodsw aoatoagom aGnia ad --_ . ar CompanySaniized.Doesnotcontain TSCA cB H24768:OneGeneration Reproduction Study in Rats DuPont 13784 [i 50 24768 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 [--]INDIVIDUAL BODY WEIGHTS (g) OF P1 MALE RATS AND MORTALITY DATA Grove: 111-0 DOSE: 1 MG/KG/DAY ovoarrs: os oe om ws ow 2ii] GwGeo2a3 4daenSme 4GS020053 SSs0oaLss0 msGaSwlee SanBriasA 5ss3aa0li.as8 s5woOoaMwrSss65e) ii3 GGSa63v35e Gesheood dfGeeeadi a sSaRaD iGssEsaSs 3S2020702 sSsilsso s5 oooawrrs9s6 335 G$B55e38 GS0e27d0 BSdemssas sgSoalmaes Msdrmhead asslaesoo G53a1l33e soswoooaarwrsese 3338 GG855n3 SaBIidLn S9Si85e5 SBSoielsle sGsiaosii sdsewelsl wSsiesslswo (oooawwroese 333 BSB31E85 GGGue3ss GHaisSl aGBe9es3s DWeIsrlo aGeomdlos usenoss wwmm ooowwweonnn aa] $H203E2E33 iEGeebds Ssfneeozd aSBw9es GSso1so assssmaai sesenedss ww ooowwaeennn raiH BGGuEdi GSGoeEil dSBeoes se ss0ol8ls1s sssaeas Hsmamesan ssBmmeiasososw ooowwweeennn ~~ iia] $3H3e85d GBBi9s3 dSWewEse sdSaaman ssSnrosl ssSleeoni ss3sil3a ossmo ooowwwenonm wooo3. sTe7es5 4B9R.sl7 sCmwWeE Sh7Bb1e SC3Wa0iE8n sC0Bh.El0 5T5e0kl.ls0 by 24 at at al Pale --_ - . 163 EBaySanitzed.Does notcontainTscAcar H-24768:One-GenerationReproduction Study inRats DuPont-13784 --_ 1s 20760 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 f J BODY WEIGHTS (g) OF PL MALE RATS AND NORTALITY DATA GROUP: V-0 DOSE: 10 MG/KG/DAY onoEwasr: 1 es 2 x 6 @ 53% 245 555% 55% aa& &&& &&& ~ 772 w5pee.nd XN mRTeoeosd dSweiusoea MdJedeses smdeaeres 9ssae3nn aadae1sn 4aids9eo2ls 2BBo33o3s 0 BSeiln 3 deehs eWandsa aaasslesso waaomhna aesolo Be3u5ds de3sES Yd3me0ua wa dno asdelmlsss easmoaas asmenss BBJ0as3 dMSoeassd dd3ae9sn dabosevsse duiessaos dmdeeesisrs adsoealsn ZBBoeiwnds 3bG2e0 a mdeeos dwdoaoadz saamsesss saseedye aaaemndda m3P2Ee dJ Maedaoes Eelesi$ae0s5a wsaeeslsos eeaesless saalawds7 BHBeEssl 3E339asDIdIEaGo dueeshar dssoehns oa0masi ooasllsss 3BR0eE3eS Sa OsE asWeierer7 wdaoernsa waeeilna msweenas eeaslas aa3s10 aRmfass aT0EoDn eNasne 4S3Gnan aS0ien efBannl 2 at at at wt aw | --~ . - 16 CompanySanitized. DoesnotcontainTSCA Et H-24768: OneGeneration Reproduction Studyin Rats DuPont-13784 --_ i 24758 REPRODUCTIVE AND PERPILITY EFFECTS WITH H-24768 { ] INDIVIDUAL BODY WEIGHTS (g) OF P1 MALE RATS AND MORTALITY DATA Grove: V-0 DOSE: 10 MO/XG/DAY ow TEST: os oe 0mm Bs 9 mL owen 55 SGa0rS6e3 SGaaamoia assoeae)e sssaedzl sssemeaess mssieaoo ss53i2s.s2 wwSmOooNwws9s8 528 8$W33S0456 BGmaeisa a3 33m7a6 sosemenss asse20s0s ssamsmiai si5es6ss0s wwwooowwwssee F3iH] 52S05506 GsHeiaac7 aSGsa6s3s aswoss dssaeesessd 4sg0wo0ls &Esnsess7 swwmDoooaawr sssene &ii SGfeeyil SDdeonnns dSGeemeiss seeaeans susseoess sssoeeaees sssaaaiss ssooD ooawwvesos &&& GBG975366 fiSoaeedsn dfGeaaemssa Ssaamolileee dsseeas sd sasollsos asseseiiiscoss oomawwveeennn a&& $SG3i35a0 Sae0mo8s SaSImmsso sssommbisa sssaeelnoe 0sde7smi s3303e3000ssssbD ow(wwvreaenmm &@& BGSih5ss dsdiadose SaG3me3ao3 assmeoees asaepoaoss lamoisdd 66a9903 5sDD w((warvvooonmm ~ 7i7 GGS6e3d3 nfGamlds dSBeeelsss sRseoeSed dWsseorrs Emssenss saSodse3as wwsmooomawreesnmm o5oo2s sWSeoe aRmSEaE swBds30 swWwdl sLCmhEai 5Cd.6n93 5nC0a.ll0e 2% af a7 Ww wt ow Ti6sCompanySanitized.DoesnotcontainTSCA CBI 124768: OneGenerationReproductionStudyinRats Dupont13784 --_ fi us 20768 RESRODICTIVE AND FERTILITY EFFECTS WITH H-24768 LJINDIVIDONL 50DY WEIGHTS (g) OF Pi HALE RATS AND MORTALITY DATA Grove: viz-0 Dose: 25 wo/xe/oAY onoTeesor: 1 ss om om x ow amos, wwe 7i ZJeeeed04 2Ja2esd 3mMaieos sawaleos aa3sr6is3a aaIsmssas aa3sselmlor 77n DDSeeoao 2MM0as5 smelssa aaamslis aawlneosso aaaslssss aaamnliiss 7&a SSBeae:i dddoana dJaeebsoe wddeeleys 3EossEs sEaeemelsn easissee a&& BSIemede dddaame la Mddes7eld I0anesds ddonanls saameiass esanaean &aa BBBeeiaia da 3aas aMJmm0es diaeeess dnmdions swaesnes damwwis 5&a faBaeess dd3mp3aa PWdeaedsd aaalbwsyee andonars msaeemlns aasmnidos --_ 555 3 JBooos dedmlaas Sddoermiz adwweed sadessess waselisss assmassos 555 BIBeoid B ddemnaBdWDens BambsSls WaBe:nh Eaamrsias Gsaaneis wS5mE 2h5S.n7hoo3Nh03n9 dheWeal 3 mnad aSeWeslinamsnes 4S.an3n at wt at at at aN aw | Tice: | 'ETpanySanfiized.DoesnetcontainTSCAcet H-24768: OneGenerationReproductionStudyinRats DuPont 13784 --_ ne iy REPRODUCTIVE AND FERTILITY EFFECTS WITH H-20768 L INDIVIDUAL BODY WEIGHTS (g) OF P1 MALE RATS AND MORTALITY DATA Grove: VIZ-0 DOSE: 25 MG/KG/DAY on Tost: 0 se on om sm amo sme 77s 93D020555 4sG2mm.s9 0sae8md6 4sm5ia1a 4ssi8me2es 4m1s0s0.s0 45911297.19 S5DD (((DooAaaYrr 95s66e)) 777% $6 G303 G6$50638 uddsaeemlss samsoisiss sSa0mm0sa0 dPse1mn7os sgi9aa9y75 8So (((ooaaarrv53o66)) 7a1 63$9379250 nGo0rS0s G3ai1nl5gs3 ssaeasallies ssa0ee0os7 mssiietsee aSs6as3 ww (o(ooawar ssdee0))) 55a 55 362 aa 3ssa esHosrssa osHirelsso idssassgso sssunelelzss sssesrvs SD sb ((oaavwrs9e6e) 5a BS33030005 SSSee6sl4 SsBt0es1d sssaoaiszs sssmsmaos sssoielas ss5sieasl $sbo (((oooaawrre ooannn) aa5 3B$0007660 aSSee0ls8o 9SBle1eiz dsBewiess dsscieaelona assaedss S5s5a00.l58 sSSboO (((oboaarrr aaannn))) 555 $ S0028 85$G55a5s44S04e0l a0sm1ea0s S9d06e50s0 ssaoiarsas 3el11e27ss3s sS&O G((oaawrrvoaannn) ~ 5%3% BS$0009577 SiSs7me6o Sdiaesnse sgsabla7s sdsiadrse sSsoealloss ssseieaesssSsbD (((ooaawvroaonnn) woaoxns wSiesr ammaaa aSsanse sWBenR sCeNWzsS sCSaans sthaohs x at at at a ala | 167Company Sanfized.DoesTotcontainTSCAcay H-24768: OneGeneration Reproduction Study in Rats --~ DuPont-13784 APPENDIX I --~ INDIVIDUAL BODY WEIGHT GAINS OF P; MALE RATS |~ | | Ee `Coifipany SanMized. ticesnotcontain TSCA CBI HL24768:OneGenerstion Reproduction Study in Rats Dupont13784 ~~ INDIVIDUAL BODY WEIGHT GAINS OF P; MALE RATS EXPLANATORY NOTES Notes TestDays 1-73 = Premating period Test Days 73-87 = Cohabitation period Abbreviations Summary Section SD. = Standard Deviation SE. = Standard Error N= Numberin Group | | --~ . - . Ter IopanySanitized. DossnotcontTSaCAicna H24768: OneGenerationReproduction Study nRats DuPon13784 - f ue 20760 ] REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24760 -- INDIVIDUAL BODY WEIGHT GAINS (3) OF P1 HALE RATS Grou: 1-0 Dose: 0 o/xa/Y onoarreesr: 1 es 15:2 2:28 20-36 3643 43-50 imo, women 231 s3$53s a1w07a7 ma waa m13l03sa 1as70e m320ss0 m1160a33 i:: ia$s45 Gd3eal5s wa olae a32sls7o asaessa d22e0ae0 2i0s3ls ;:5 5 35633 8d4s3 msmss1s h3miss a1m9rss m2 lsasa -11am ess 111 i 3360 ma3l817 8mwhas amsmaees maaa3s ubLlas m1 mas 1Fisl GSde0eo isaenne wwwmaa3 aaimhs mama3a mmdeals a1en3g i7i $Sfe3an @am:nizss amRsnse mdonbae madeans 2R0n0 doaaasan --_ 1230 G3@645d5 da3oass pe2ao aaIwsses adwsesss 2maa0sa6 17a82a7 242 33F53e saoemsna mmBl1ss amDivIre oRlwses aLBelY b1ois siomel 3sTsoe a7iase me1as3 asdsan sffsnn a1ian 1n8sn% x 2 wt owt at at a 2 | [ -- we EompanySanitized.DocsnotcontainT5CA CBI H:24768: One-Generation Reproduction Study in Rats DuPont-13784 --_ se 20768 REPRODUCTIVE AND FERTILITY BEFECTS WITH H-24768 [--] INDIVIDUAL BODY WEIGHT GAINS (g) OF P1 MALE RATS Rove: 1-0 DOSE: 0 MG/KG/DAY onaTvEsST: S056 se-63 63-71 7178 78-85 ss-s2 1s ANDNAL NUMBER 12 3 1637 Ls 133.03 wz o9l2s mls 1sl3s 1 27.0 Ten 6e4a m229a07 67 ae 35 s w36ooweile a5 194 0G1E a0 sgzn 2.4 16as 221 a13s3 a2m3l6 176 3360 75 5 3S3o8 227s5 112763 ne Gel 3 sos s 11002 2 als 1523s a3:m3a3 wa al 1u0 2 5S5391705 assise assss 1s2s 0-6123a 226m69 200 es 84 4 0s 9s 219 b1t 15 [377 10 adlaes 4 0ow0 ea wsos ss 11s5l2z 185 aa7s sls aa2sa2sl10 1u6w 18 1136s 122 msllss 3 mmia oemlas 23 a 1210 0924 2an0l307 aa 33 el --~ 210s 21 129079 116a6 m7ias 185 ios 70 1sls m1l8s0 sz as 583a a2las 7a 2696 223 20 1S 33 8437 123 awe 7sl3s we m 47 as mio si aly as2r a20a0as 77 als wseDn.n sz a2m8s 15 1T2e6s 33 10s.n5 a2 120041 21 11239 0 7sl5s 2l00o0 2a 20 13 w 2 20 2 2 2 2 2 | ~~ . . I BompanySanitized.Doesnotcontain TSCA CBI HL24765: OneGeneration Reproduction Study in Rats DuPont13784 --_ fi i 24760 1 REPRODUCEIVE AMD PERSILITY EEPECTS WITH H-24768 INDIVIDUAL BODY WEIGHT GAINS (3) OF P1 NALE RATS nove: 111-0 Dose: 1 o/K/DAY onoTaersst ie es as 228 2635 3643 43-50 J-- f22F6] 3G$9o9.s5 mddezoa oammaua smDeBsAs m2Bbas s2m6a12 a1ne7h 2358 S$Gi0se1 BGaLss mdsieasyn 3dm0es5s a1de3essd zlaaas.b uaala1 33FS SW3si1 mBseans swLezls 2mB3as mmBsss gBseEos ladene 333s% 3BG7e70a aG%3e7 asSlwsee ezadezid zaaim2si msslsss weellles 33 3W205IRBaDse mBeSse 1wdaabp wasosa mm2eahsm aoasluln ia@ BBS8oo3 bHGleSeo aBeisn 2mh62s7 noaesss naeshro o1wall2s --_ i@is 3BS8as S#WeE0s MeBeEB BmDsao ZBomasy maaab3 1us0sh7 iis isSehoundWdaE foEmena 2RB0eS0 m2Ba2E oBwpas abalans saoexyn aor6so aeI7s meiar oWImsna efisenn 2s10s aWasns wt oa wt at at at a --_ : is `CompanySanilized.Doesnot containTSCACBI F-24768: OneGeneration ReproductionStudyin Rats -- iji ff ] REPRODUCTIVE AND PERTILITY EFFECTS WITH H-24768 INDIVIDUAL BODY WEIGHT GAINS (g) OF P1 MALE RATS arovp: 111-0 DOSE: 1 MG/KG/DAY onoTaetsst. 50-56 56-63 63-71 7178 Tess gs-s2 Ano Nos 2285 x 17s6 12: 04 0as 1s6a7 nls 57 81 1253 7s2a sz 7537 8s 2FA 30 lLoss 2`2e2s @4 204 e7a2 ao-0oo 7.6 as 77s8 11 3e7s 61 5a2n l1o3l6s 11 1l5e.e4 1a 4 ass es s0a7 sz seles 1908 1s8ss 7.3 3336 i20s06 ils 2f0o0s8 181 a7s.s6 1303 ans -3 23s.l8o mio a80 isle 3 39 2503s 162 2520 2008 0S0e7 alTaso -Tael0s e317 -12l0 d7.o4 sls a0 2 w16s7 143ss aasse S1la m13is s12l0s4 nls a9 17 as 1207 9a -- aBs as 1a7s s7 a1ss 162 2l4o3 ae a2nas sz n2i1e 2-0953 208 25 iac l1o5lss diolte lsezs 1a2l1s a258s 115930 hy 26 ele 24s so 137 aie a 5.0. pes 131.2 aSeE whso os 12 12 s3l4s 20 796s 1s e9n9 a7 2 2 2 2 20 2 DuPont13784 1-92 a2w8aa a25m0i0e8 2s6e0l0s9 328133 222080266 2241ss 2a0m0i0s9 3323650000 22ms3 22160033 22809030 320m2l1s 2s6e3l3s 21s --~ . 1mCompanySanftized. Doesnotcontain TSCA CB! HL24768: OneGeneration Reproduction SudyinRats REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 DuPont 13784 INDIVIDUAL 20DY WEIGT GARNS (3) OF P1 MALE RATS Grove: v-0 DOSE: 10 MG/KG/DAY onoTaExSsT: 18 eas 1522 2228 28-36 36-43 43-50 AnD, NOUBER 5a0 5 33.%3 B03 o3es sal aa1s 3 a24as a7 amsah mle w26l5 as 21042 sie 52 5 2a07 B05 laolls en aesiiss71234s 1w8e4 sla 1167 as a175l.s0 65 5 SWiis $2 amlias sas smlss as 123003 132 2msl0se6 2is2is a1 628a.0 ais 555 s0 339504 D0 amlss wa 7 ser a2 ma33 as 1oassis 261 2s0iss 28 1u3a 180 aa & 3So0l5e 3s sameo des mdell m2 ale2e 24 2a7s 21s 2100a1 24 2s1o4 62 &5 56 3B0l3a 02 zoaa a2 solss as aoses 28 2is7is 2s zms3 as 229406s as -- &5a 3$BsIa mmsessz mwahn1 omamo7a eles 1 msss 2a e1l0s uz n70 2 #366 $35 wess ds mmms22 2220 als m19s0 ms a1ns als 28s0 22s 5E.a0. SE 33.29 8 D38l2 B55 msas i 122032 2s 2s7 es 2a an 2 175a .7 als H 2222222 -- Tne CompanySanitized. Doesnotcontain TSCA car 124768: OneGenerstion Reproduction StiundRatys Dupont13784 --_ (a 20760 1 RSERODUCTIVE AND PERGILIT EFFECTS WITH H-24768 _-- INDIVIDUAL BODY WEIGHT GAINS (9) OF PL YALE RATS arour: v-0 Dose: 10 wo/ka/ORY onomeess: sos sess em Tre Tes ese in smo yee 8ES a mF1J6raA 1d00 Eammo CleBaE E1Nscn. S1N0Eh0 aS21s16h12 Ho B30 an S28 2h al zen 55a5 3 PT5r0 BBdeEs 5 BE ahBdne Wn BaB3In0 a NdNEnE gE abNhEn aamaannn Gan ml H55 @ mBmaeiooonmdEsnoou33s3 RSEnee 55 ad wn aes kwsn5i 0 wheihne aaansnhi don an awn @aa a W B45oi obe iae: wBaene H3EE3n BfBnno w9Bemnn dBalasgs Wn Bn NS WT an wl els --_ @&a @ WSiodnaene oe 3h 8mEmnE ms B79n3 BaAsnn aan 1s #aS3nn Gwdasnl Is sms 5I@% W BL5E0 ESoodwdnn omOaaSon adsGnm3 8aNlDe wNBnEE adGeenln a Wiad WS RI Bo se Sols sm8Faa 1ei ar 3mMa3 zEO3mWo at at aT 32E38 ansBeS at at aGanlsa aesknsG wat a -- . . Te | CompanySanitized.DoesnotcontainTSCA CBI H-24768: OneGenerationReproductionStudy inRats DuPont 13784 -- se 20068 J REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24760 _-- INDIVIDUAL BODY WEIGHT GATNS (g) OF P1 MALE RATS Group: vII-0 DOSE: 25 MG/KG/DAY onaTvEsST: ie ss 1522 2228 28-36 36-43 43-50 AOL EER 77% 3 3 25.2 ao w39s.6 ae 0 sms 3:3 2915 a2 110sa me 278.39 1s l8s2 13 77 a52l0e1 3000 aesa 21025 2sl3s 21580a 427s 27 50 5B0s3 Gls alies ae m1a m7 e10as 2s 282 10s eas a 1a 196s 201 aa 8 239026 35 026.063 37 22827 a1 24s6 mle 2mlas aso 11737 26s 1246a6 aly a8s0 86 6 Go S10 aaler asls 22071 ee 21894 212 aalsss 21s a2:22 210 asilzy 283 aa8 8 $3055 Ps osalsiss a1 23ss es 12s9 2055 218ss 26s s1las 1s 1172a8 sls --~ 100 0 336%3 $200 336s7 asia sazs 2es 2s3lo 202 321 300 12801 2903 11s 2008 %9 55 a32 300s a3l0s7 288 323622 290 2185s3 17:2 212098 243 2250.14 244 1e6l0s 87 % 1 sls 6 ow 1a m2 wa 5n.y 55 a702. assls 3as 19e.o6 2e0s0 210a0 146.06 15 fd io 12 1a as 12 H 2222222 | . 1%6Company Sanitized.Doesnot contain TSCA CRI H24768:One.Generation Reproduction StudyinRats Dupont13784 ~ ue 20763 (1 REBRODUCIIVE AND FERTILITY EFFECTS WITH H-24768 INDIVIDUAL BODY EIGHT GAINS (9) OF PL WALS RATS Grove: vIt-0 Dose: 25 WO/KG/DAY onarvass: so-se sees em Tits ress ss 1: mo women 77ns WWseu inDs37 BaoeDss oa0w9rn waslass w16r31 aaam7es 777 BwS5ee0 81s3aa lzBoene 3l3s6 LaGEeh mi1h7 m2aas0n 7aas 1Ws0r0omeas 3dSons ahlissn Bedehlls aoswslhs iammslss a&@ W150s33 0wdesae owS3llase i33z52 mzmaez 1n33iss aaaumas ln oooss 5 2G12 ealeses awSlmesa wo0sn3 m1hass ooewlnss aagsenelhs 55os wiSoEealwnas oe7wr7l BwMaE1 owN5lE5s aa3osl am2w0sls ~ 525 eWWoee daSnlns BwEEle aaennn naarsha sllssls amsoomlrss 555 2Nw00i5EWaSwMe Bwmsle oo3ns hawlals d32hh kaawslh wSonnE! 2ceaa Reo1m1a B1Ba3E W1asE3 wN3ads eassaa 2f0ahn0ns H #0 wt at wt wt at a | Tie | `CompanySanitized. DoesnotcontainTSCACE. 24768: OneGeneration Reproduction Study in Rats --_ DuPont.13784 APPENDIX J -- INDIVIDUAL BODY WEIGHTS OF P, FEMALE RATS DURING PREMATING AND MORTALITY DATA | - mw _______ `Company Sanliized. Does not contain TSCA CE" H-24768:One.Generation Reproduction Sudy in Rts DuPont-13784 ~ INDIVIDUAL BODY WEIGHTS OF P; FEMALE RATS DURING PREMATING AND MORTALITY DATA EXPLANATORY NOTES Note TestDay7l = Last day of premating period that data were recorded. Abbreviations SD = Sacrificed by design `Summary Section SD. = Standard Deviation SE. = Standard Error N= Numberin Group | --- ww `Company Sanitized. Doesnotcontain TSCA CBI H24768: OneGeneration ReproductionSudy inRats Dupont13784 --_ (a 24760 7 REFRODICTIVE ND FERTILITY ZFPECTS WITH H-24766 --- 12 5o0 WEIGHTS (3) OF 1 FRIALE RATS DURING PREMHITNG AND MORFALITY DATA cove: 13-0 Dose: 0wo/xo/AY onoaesse: 1 sos om om x ow sno, ves 55= 100 JvBoeses on daaehsos Bee dImnmsaee des aBmemSaa ama aNasesudos seo aN25es0 ana ad2se6an4 ass 1ii0nn 10 niBesdd Mad Bdaeeeods Ro aaaihmaae nn maaiaNend dha I aSmos we eddeeneyd aka dggesen mss 111000088 BSBeoeysi BdBieeys BmaeDos dmdnmndas Iamm0no dsmeeEdn dadoee i1100 fret SBS0oe0ls3s aaBeesd aMawIesaD dE0ee1on adgmmenas smgsei5sd ea0ease fo ns 3M 396 dey aes amen i3mna lDBo3ao3ss0 iaBieool dddiueeoss ssdaapssas madse02s gadeaeess asawemdes -~. iiiss $SHao8si Gdaaamosyna aaaamnna saimaeaad aammmlos aadmmaeos asgeass i| Fide i $0B56e68y IoEmnSas Fmdeialnn EdaweSss mBaeoessa asdnesyd Bsgeesnd sp5ne weSsaeenmhn2n mBBDssO en hs 2f0Ns0e 2u6h9ns0 2f7ha.En0 B af at at aT at WY a -- . . Tio `Tompany Sanitized. Does notcontain TSCA CBI F-24768: OneGeneratioRneproductionStudy inRats DuPont13784 --~ [ 56 20768 ) REPRODUCTIVE AXD FERTILITY EFFECTS WITH H-24760 _) BODY WEIGHTS (g) OF P1 FEMALE RATS DURING PRENATING AND MORTALITY DATA Rove: 11-0 DOSE: 0 MG/KG/DAY onDATYESS.T: 50 s6 a n Am oBER, 50 9 226650.14 2953 72726.25 ami 2270320.54 913 2288521.30 sSDD ((DAAYY 111001) 29009 sp (oAY 102) 10001 102 2273950 2307 a2e73z 741 222787659..0430 3208361.10 ssDD ((DDAAYY 120018)) 285.4 sD (AY 101) 110083 105 22989987 2614 3370330.51 eelo 29889.053 292.3 239042..79 SSDD ((DDAAYY 220032)) 205.7 SD (DAY 104) 110078 108 23604'1s 3e's 321729.078 3211 a278s12 37. 328154108 SspD ((ooAAYY 110070)) 3261 sp (DAY 104) 10190 pros 3355021022 esis 3m0345 2066 3a0m0s1 2983 321836072 SsDp ((oDAAYY 110034)) 307.7 SD (DAY 104) 12s fr G7a0l0o7 e702 320100 30903 229m3l0s7 31006 230351.57 sspp ((oAAYY 110004)) 324.0 sp (AY 104) ~~ 111155 nr eZseils2 5105 2a92s.2 2897 235121)2 3072 23710021 Ssbp ((AAYY 110003)) 30611 sp (AY 100) 1198 120 3e7l50a5 3860 326090..7 31 229191013 306.1 231820.31 SSDD ((DDAAYY 110013)) 3185 SD (oAY 100) esoa.n siz aTmoos 38 21741 3s 2116s2 33 2919.44 3h x 2 2 2 20 - . ILC 124768: OnGeeneration Reproduction Study n Rats DuPont13784 _ fi diiia 1 BBY emer nmrs: sn, snes ii11 i3i 1ii 3Fio FFiHo Fioni _ iiEnnH ibiY i-x : ARTROPORTIVE AND FERTILITY EFFECTS WITH 24768 ee emo ees me mare wo roan es Grove: 10-0 eenose: 3 wore st se: : eis om om x ow nmpeaeeseooaMamm3arrommmeesss mes mand daaemmdis md dEaslSa nn ammonio damn aRsesSs aa mmBEdOSoORBDEEeeSd mes Es mBhydue mil fm33nd0 md mfBeasns ami eddamssa ms wggaannn ons mmPIaDeodmOeeIsn mer nes dddaewess Me mdgadis md EmBanoe deapeenss wn mn mm0ons son mBmeOloOoBmgedsr mel Ome admmdsl mY dfmenn ded Gamminl Een Gawmemenan Gm aemens Sel m m neem pmed abe ner omfmlis ws miBeend am ddBesml nol mmaaths mn aaaaannn ed #nmesDenoBpdeeyl ddomneg mRHeEil RdmOnn moEanDn memasdn ESHER re rH ae2el3oNamm0Ss oo mWsoYsmnoeWCEndE a at at aT sEeoEnn at mEeuEad at aumunad a ; . . TT BoipanySantized.DossnotconainTSCA CBI I ---- ~ pg FE -- ML DL e rn m moeeT sm nesL emomene so wa = oneon | | Bornsts.sosrtcn T50n H24768:OneGenerationReproduction StdyinRats ___ DuPoni7s --~ ( uv 20758 1 REPRODUCTIVE AND PERTILITY EFFECTS WITH H-20768 _-- AL 50DY WEIGHTS (g) OF FL FEMALE RATS DURING PRENATING AND MORTALITY DATA nove: vi-0 Dose: 10 Ha/KG/DAY on'oraerssr: 3 3 = mos wwe i124s oo18so2.so0 eB20ao3a2 gaalemesss aaabwmse2 azmea2as m22a0l32e 332356s21l.2s0 111% RoReiIesD eoBsee saceeasso wsseeasas saaeemeoss 2asmeesso a229sm5s3o 595 fHSieoes. GBBaossws aaddeeoss asdeeossn ssmemsse rademwses aasmemines 1115336s $3$a003: GBGieeaso amaalaasa ssmeesse saeesnsss saamemss 2agia9ss 1113555 J9Do3av0si8 GGGaiisselsmeainao dasoeelosd asawsseoa 3zae6maaol l22619s8007 11166620 oD$l37s5 3d10o37s aBasesllso eaamama zmzeieeoa aaessrios aazmmeiiee --_ 166 16s oSolssa 1790 8i.o3e iste 2s00e41a3 asassselees aezmssiares m2281o02.s34 23a0em11os fe616 Moiozdwsa BMoeeeals EdaeCoe IsamEaiSos Mspo0Y7s EmaeiEss e1se3nl6ds3 sS=E!y 20T52o.2s6 ahnMssE mWeNIas ama Bs 2"0RNl7Es 2`9Gm.na8 1t9Na2Sd 2% a wt aT wt at oa | |~ . || . BCH BompanySanitized. DoesnotcontTSaCAioant H24768: One.GenerstionReprodSutucdyiinoRants Dupont13784 -- uu 20758 REERODUCIVE AND FERTILITY BEFACTS WITH H-24768 [ --- 1 500Y WEIGHTS (g) OF 1 FEMALE RATS DURING EREMATING AND MORTALITY DATA ecovee : vi-0ee Dose: 10 -- wpo/xep/DAYeet onorreesr: 0 sow om pe-- 131i158 2efegie.ss 2saemess 2aa8me.ds1 2az7me1sa4 >ss>aGGAarYr 11100082m)) 111332089 15 JS$aa7sn ddBaaeena Ms3eeasds m2solsasos m5a oooaarralononn) S033 deo Jara ars 8 AY tom 11155% 135 JDIoon0waa sadsaeolyes aaemmseisss 223009980720 555D (((oooxvv i11o00n33))) 3031 Goss aisle 31905 5p (ov ion) 113133576 S$fe3al0vo3e eeisesasa z2ae9oaase 22391992633s 855 Oooaaarrr lilooownn) ii1ae35 SrSe3rsv0s emeaienos aeaselisea 22a68o10772 555 GGoaaarrr 1li0oo3nn) ~~ aa 1166s S$0o6s3 3S339530 diews mSelass aseerlas aoezs 23393sa4ss s5s GaGaaxrr 1t1o00n71)m 27 s Garon i116s66 BSSo1e3s fsdeeeenes saaevel ss o227n3saa. a5s GGGaAarY rlloooza)) seppae.n 210s56s33 2hM e9e E2E390527 3m0as1 at at at aw ~~ | |! - . TiS CompanySanitized. Does not cantain TSCA CBI HE24768: OnGseneration Reproduction Sudy inRats Dupont13784 --_ ( i Saco i REFRODUCTIVE ND FERGILITY BFPECTS WITH F-24768 INDIVIDUAL 20D WEIGHTS () OF 71 TRIALE RATS DURING PRENTING AND MORTALITY DATA ereerra-- cove: viEzEioer Dose: 25 wa/KO/OAeY tersmeme oromiiss: : ss om om ow @ mos, wee ii1n%0 in TI aemda Ter Hemsesss Bed BBmsaiane din dMawmTse sen gI2n0en0o ses sg2ee6al4n ama aaamlizss mz iR7nAs 7 I0e3es Bes ddRnwNiss By EdBNeeDas dna GmdeiEsnR hn IaaNamGas ma saaansne ad aaammeiese as iiR7nY BmIeoedy ney dn3mesiy adn aadbmsda 30 aamkenan amy Mamse0er Bes maasshds mb daammeilne sal iiine 19 nmTeeers me mdaoehdn amd mddeenld ims anm0e3)l aml Edme3sd El InImSSD fer Gaseenlle al -- 111a9 i m3i03303 3Gao9msd%s EBaemess mmmeenln 3gguaess daansssaa aomassnees Bsa ahs mi Pnl ded mh sels iiina FH BBBeEEs edGeesaa BOs hdmeeaas ed AmBeEss I0 Inn BOE dEdnlhl BD aaammnise Sel wFaaEen JoSSses6umHr3ne afmMnaS aMeoSnst aMsmasEd 2E6B4nE6 27f5he.En1 4 at at at at at a Tee CompanySanitized. DossnfcontainTSCA CBI F-24768: One-GenerationReproduction StiundRayts DuPont.13784 --_ [i 56 24768 REPRODUCTIVE AND FERTILITY BFFECTS WITH H-24768 - BODY WEIGHTS (g) OF PL FEMALE RATS DURING PREMATING AND MORTALITY DATA Grove: VIII-0 DOSE: 25 MG/KG/DAY. on TEST: 50 ss @ n TAL NouBER 16790 m 92161.73 3:03 2290900.03 29003 228916.09 20611 239022..48 sSpD ((DDAAYY 110022)) 30615 SD (DAY 100) 17723 78 eesllo0 eels 22986910s3 200s 320006..34 20.0 331016..77 SSDD ((DDAAYY 110003)) 288.9 SD (DAY 103) 171785 m7 e27s3i0s0 36.1 227066.37 2000 3209300153 26000 3300006416 SSpD ((DDAAYY 110030)) 2731 sp (DAY 101) 171789 180 2s7i2z7 3974 22608057 36.0 220870.88 3247 229929.052 ssDp ((DDAAYY 110073)) 32.5 sD (DAY 100) 181821 183 2S903088 3858 239094009 296.1 330120..21 2943 232955103 SsDp ((DDAAYY 110023)) 294.3 SD (DAY 100) 11885 186 327660s5 3560s 32713038 2610 3216370.71 2801 32088176 SSDD ((DDAAYY 11003M)) 293.4 5D (DAY 100) --~ 1T8e7e 189 2296660.48 206.7 32616..01 2612 236351.20 2618 3216871.33 sSDD ((DAAYY 110041)) 261.5 SD (DAY 101) 11% 220095003s 228369.011 226803.33 2296301.55 SSDD ((DDAAYY 110022)) 192 3153 310ls 3230s 32604 sD (AY 202) esDn. SIE 201070.31 28t6.e4 29e1l.a8 29a6s.s9 3s 3 3s 3s 2 2 2 20 --~ . . iE CompanySanitized. Doesnotcontain TSCACB" H.24768: OneGeneration Reproduction Study in Rats --~ DuPont13784 APPENDIX K INDIVIDUAL BODY WEIGHT GAINS OF P; FEMALE RATS DURING PREMATING | oe "Company Sanitized. Doos not contain TSCA CBI H-24768: One-Generation Reproduction Study in Ras DuPont 13784 --~ INDIVIDUAL BODY WEIGHT GAINS OF Py FEMALE RATS DURING PREMATING EXPLANATORY NOTES Note TestDay7l = Last dayofpremating period that data were recorded. Abbreviations `Summary Section SD. = Standard Deviation SE. = Standard Error N= Numberin Group ~~ -- . | . BCH -- {Company Sanitized. Doesnotcontain TSCA CBI H24768: OneGeneration Reproduction Sty inRats Duron 15784 _ ASPRODUTIVS A> PERTTLETY REPEC WITH H-24768 (--] 20D WEIGHT GAINS (4) OF PL PENALE RATS DURING PREANTING anon 130 JA---- o. res srs, sme re eas asa mas we en oes =n2 i 2RB5OOBREBDSD 42H 08O8u 0 B8o3Yw0 Mu D waHeD 43 4 3 an i Trond omE ol oad Bi i 10 nw: 3 Hp ome oer 2b 38 1>=% 1 Emg1rroaouonBdroM2mmdoiowmmseodu aohdns loaaoWd3udl od5uuddd -- EHI] BTeiooaR3ds W8o3 oBaa BBeIW33 aad 1iwn] $B3i3 B0%B3ioBso3%5: komsR oaUo l woa8e8 o33u3 _ . . "i Fompany Santzed.Dossnot containTSCA <1 H-24768: OneGenerationReproduStcudtyiinRoatns DuPont-13784 --~ fi 5s 20768 1 ---: REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 BODY WEIGHT GAINS (g) OF P1 FEMALE RATS DURING PREMATING Group: 11-0 DOSE: 0 MG/KG/DAY ow TEST: S056 sess eam am AHA BER 90% 59 mw1i s3e3 wsals ms7o Nz 202 0 slo 10001 102 3a770 2271 w7s0 mssbs 234 23 so ena 110038 105 B3a aIsllss ss as as3i asoolls 25 92 110087 108 18327 l12s 26 37 21ss m7l8s9 e713 10190 m 1B320 eslas wsiz wmn2 81 a3 ss 000 1113182 3 N50 s3ls w2ls assls 21 13 ule el ~ 11185 G0s3 a2071 2lso oelzs 1178 119 262s w1i4s 2005-05 au1s 9e23 122 1033 120 2056 as ala ous i r5e.0a. SE sssa a7s6 1s6s 3a0s 15 1 12 2 | 20 2 2 2 -- ` 1 [CompanySanitized. Does not cantain TSCA 81 H24768: One-Generation Reproduction Sy iRts DuPont13764 --_ f us 20768 1 REERODUCTIVE AND FERTILITY EFFECTS WITH H-24768 _-- VIDUAL BODY WEIGHT GAINS (9) OF PI FEMALE RATS DURING FREONTING Grove: 1-0 Dose: 1 kone omer ees asm mas ae en ae seas amen mEimH 2WC63s 1BB2IEs aWsys3oamne Iwurs 3TdanE 3eisn E1132rs aBsnEpeodSmh wpMlsy Leeyhs ooaBdenEs aisnmh o3adb iii wSSiaenIae msh3aYoaGSmsl EG5Es 3asdmen gignan 1a25 3amnedoowBtnSnoowBNnEn aoda8naiwmnid g3wn%e 38 F33H% aPT danidaoEwidaEm nWnsm dadMns aE Nns 33dann F35d% wSsse SEBGonooawWnaE ds 19 fHsosel aw3enms ugi sd ~ iiian waS5ieooamdsoieoodisdse dadande nN10nn5 RNa5dn0 aasnd 1ii6G 2W3 3ins1e35 a2as%a aMan2n BmB3da0 wWfsEe 3333 d sa35ne BneeoonEmee woTenee aammees mImamn oaadda aasnne B af at at a at at ad || | --_ A . . ------ ------------ BompanySaniized.DossnotcontainTscA cay H24768:One GenerationReproduction StudyinRers DoPowlyse --_ se 20768 [ 1 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24760 BODY WEIGHT GAINS (9) OF FI FEMALE RATS DURING PREAATING amour: 9-0 Dose: 1 wo/xaronY onoamiresn: sos see em 1m Jno woes m32 0FEs3CeT 2GI4h LTaola ssea1sn 15265 w2S35i0 oo7s@l%o 3assrs 7aw7nl 1ki3sx W o7s3 as Was33m53h2 aweboal 11333% a2Sss31w22a a70h7a a2 ellss fei13s 1070335 ws8ehz 2s333s 1so2o6ass 131b3%8i 1B33031 alNTl3Ss0E mBaaEl wwseeeais --_ 11316190 Naa:o aB3ls3e afan mNlss so als 11860 3ni5h aMEaern aaH73E 0wesld sm5. 2 56T3 il680ssonsweo 9h:u0 Bs wt at at ad - R Te Eompany Sanitized. Does not conTtSaCAicBn 24768: OneGenerationReproduciionStudy inRs Dupont13784 --_ xs 20768 IL REFROUCTIVE AND FERTILITY BEFECTS WITH H-24768 en B0DY WEIGHT GAINS (3) OF PL PRAALE RATS DURING PREMATING Grove: vI-0 Dose: 10 wo/KG/DAY onoTarEsT: 16 eds as 2:28 2636 36-43 43-50 mos EER i11a3s6 2B 20:. 738835 aB9hn7 aYssesr 3wo.as6 l22sys 9ow4alhs 15116068 W11w95:3 wAmaso mf03a5 m1@7ss oa2gnas owason a3is3ld 111555 1a 124% dawlsoe wBaads a1lee2se wwabos oumzha o1u1l3 1113555 220s330a m%s wBmsEr oeSalsns ah1eos ao1am2aa aeslos 11357 139 3 we %: wh 30 31 BEas aaa aise eo 1ssh 167 aisioes assbllss 116616210 D12e0%o3 w8as33 pbbulenz a 2N3s mwaasi awsfoo:s ows3ld0s ~~ 1116663 2S23552 3Bw1hl aG34s 7s7ns amslias oamlizs 2os00esls 11106%67 1B283s%5 af8ssa m1eo3a a21s24 aBmsohs ma3hls 12s2s | | w5Sm5E. 01$3017M5a 1W32E% w7Bh3h mUia3s w9Gra3 1eaa hk x at wt aw at ow" a a --. . Te CompanySantized.DoesnotcontainTSCA CBI H24768:One.Generation Reproduction Study in Rats DuPont13784 --_ us 20768 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24760 (--).. B0DY WEIGHT GAINS (g) OF FI FEMALE RATS DURING FREOATING Group: vi-0 Dose: 10 Ho/xa/oAY ou'onaaresn: soos ses en 1m nm omen 1rb4isrd ws1a5os.1eah mnHann osomenasd 1115185 PsS6sr0 ic9oe3sJ oMf m1 a an 1553 dBevhasoohmonanalnWgloai RsE i51s nHiais ooaasnsn wNosEe ahsnesdds i113%55 Dw23a3 maSeihs awanls aswmelss i11aa% 3 aa3 3aa3En wIsdammoaeaalss - 111666 B353050 L aSnn s anwse amaasdn 116666 a20o2o s3sn5l aWN3EE Nmmnss sioe ln a 3vse onsiosons8as oaEnnde wa 2 22 | --| -- es CompanySanitized. Doosnotcontain TSCACBI H24768:OneGeneration Reproduction Study in Rats DuPont-13784 ~ 5 20768 [--] REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 BODY WEIGHT GAINS (5) OF 71 PEALE RATS DURING BRENATING Group: VizI-0 Dos: 25 MO/KG/DRY onDTaEsST 1s eds 1522 228 26-36 3643 43-50 ANDHAL NUMBER 16177190 mB3ae30 2lm0rh0 1m2i5 55 2E3h wa 170s7 27 e9n8 3ssa sls als 1mm 3371 o30e5 75a 2sa2i asso mmaa 17sa 1177ss 176 28lo Bs 13a 18s w17a m7 lsee Zi aosns m2 a104 ss 1ao0l0ss 11778 7 1s 67 l1o2 as 1w1o 1 sess 97 1io2l me 6s4a 40 0it0s 3 11808 18s5 l2as 137 wwms 1san 1161 ease 161m3 2; d1e6l2s weas wasz melre 1133-201802 t1e6as GB5a mmloe 1a8s1 a7s0l mnliee 1s3s d0osis 110067 14ss eNlse wssls asas aalss aal3s oslls --~ 101598 m16z3 aYes s2o wwile iassa m32s oGua 111959201 nw5ss &0 aW2s awBnoE 220325 1H36h3s was1lh0 a15a7 il p5op.d 5.26 1h6o0 2W7e 7e7s 1T0e2n 1a06 4an9h Ii 2a as ale 13 1s ale N 20 2 2 20 2 2 2 | |~ . | 196- `CompanySanitized. DoesnotcontainTSCACBI H24768:OneGenerationReproduction StudyinRats Dupont13784 --_ wu 20768 [ _-- ] REPRODUCTIVE AND FERFILITY EFFECTS WITH H-24760 S0DY WEIGHT GAINS (g) OF PI PENALE RATS DURING EREANTING Grove: vizz-p Dose: 25 wo/xa/mr onoTarass: sss ses em 1 amos wee 27069 B3Go3o 3n3%eh waBwsnn sswezis RR7AA w9$3i0 93o3ahn wmhnan awwens R77i5 3ifosE8dENnE wSainaoawmndn 711750 4wS3eiomnaan o6iunl aowamsn 11106023 0Sa350 on i6e1 wBoaoiommsnss 11100605 a$Pn3osNiEra a33s53 aaTnalsl ~ 111005 wWwesh Wadnneo a321s saadsl 11559% BaEI3HS CaCn SwRaJ) esdd s=omen 6Se 3o edsoo seIr:s euBnso 2 wt oat a { --_ . . | Tor || CompanySaniized.DoesnotcontainTSCA CBI 124768: One-Generaion Reproduction Sy inRats Dupo 13784 ~ APPENDIX L INDIVIDUAL BODY WEIGHTS OF P; FEMALE RATS DURING GESTATION | | ~~ || - | ETE Company Sanitized.Dossnotcontain TSCA CBI 124768: One-Generaton Reproduction Study in Rats Dupont 13784 ~~ INDIVIDUAL BODY WEIGHTS OF P; FEMALE RATS DURING GESTATION EXPLANATORY NOTES Note This appendix contains data from females with evidenceof copulation observed. No gestation data were collected for females with no evidenceof copulation (whether a litter was delivered or not). Abbreviations G = Gesution NLD = Evidence of copulation observed but no litter delivered; data excluded from statistical analyses. - = No Data `Summary Section SD. = Standard Deviation SE. = Standard Error N = Numberin Group --_ --_ --_-- `Company Sanitized. Does not contain TSCA CAY HL24768:OneGeneration Reproduction StudyinRats DuPont 13784 ~~ 55 20768 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 [a]INDIVIDUAL BODY WEIGHTS (g) OF PL FEVALE RATS DURING GESTATION Group: 11-0 DOSE: 0 MG/KG/DAY cesamvasT:IOn o 7u2 asmaLtus ANIMAL MBER F5%l 55 230033.011 2070 332260.18 33sla sse.l esis s4e0l7l.s0 sels 10001 202 2301378 25's w3assls 338 a3seslss 3831 aasisa asal0 110034 105 3Jo2sliee 943 a3e7ss 317 3e9r1i 35300 age7il 40909 101078 108 2S812607s 32507 332675 300 3msa9lls8 sls d32e0l7s amiz mo 111009 238:8032 3as2s0i3s 3ma2sls 4a0s1s2 mm2 3300770075 3du1e2lss 3a6s1a 29-98a mo m1s4 e32e0l0s 3eal2ils 338963.053 4o4a8s.e7s py 11s6 320580s7 s0o1l7s s3wllsz 4a6rs2ise b1r s S29006070 3e3e2 33s1e3lss 4a0s7ss 10s 31s>l0 332 7 se2ls asl 5.n0.n 30B23.07 3w2a 3a6l.s7 aas HSE 228 236 243 2sls --- . a Animal delivered prior to collection of Day 210 data. 200- | | EBompanySantized DoosnotcontainTech ror H:24768: OneGeneration Reproduction StudyinRats DuPont-13784 SUE... ess rc ss -- 5s 20768 REBRODUCTIVE AND FERTILITY BFFECTS WITH H-24768 Group: 1V-0 DOSE: 1 MG/KG/DAY cesatvasT:ION o 712 msaamrs ADL OBER 1m22 123 32012.088 332309.i0 336m0l.a2 aas8si2s 2960 32601 asia a3si2 f1r20 126 232070023 33066ss 333080l3s asreilas 2008 32707 3el0 aa3ls 1128 a2l8s2 a3s:i13a a30r0ilss a3s0s8i0s9 mo 121390 131 220996021 e30l90e5 m33l11z9 431868.60 2065 3342 sels ans 131332 134 2383950072 2m9l6s7 3a3l0s3 m52i70l0 29707 391 3m ans 113356 1 3322650012 336900073 3a9l90r2 s50u1ss els 30a 338 as -- 11398 3320m04 m30ss s3e2s s32a0s1 wo 110 32604 3267 36a 316s wo pr1i0s2 103 22003010s5 3a3i2s0lse 336s920l3s aaas2llo0 30805 3wslo 31a 60's pr 20002 32ele Isls azsls 5.e0a. 0215a B2e2n s2e6s5 assed Hpi es 2046 2as 2sis 2a0s | 300CompanySanitized.DoesnotcontainTSCA CBI H24768:OneGeneration Reproduction SyinRats DuPont13784 --_ 5s 24768 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 [m--]INDIVIDUAL BODY WEIGHTS (g) OF 71 FEVALS RATS DURING GESTATION Grou: vio Dose: 10 MO/KG/DAY esTaAvsT:ION 7 1 ps SAtvanresr Anno, woe h145d 147 Jaoma.n : Beia: ss 2d9e>s6ts aam= s no 181498 150 malsss Sal 3e60s.8 en 2 390.9 eas a4s8e2z9 ase 113321 135 06-.7 7s 329 3a 063s an- a ass 11335 136 3Ja0ss 323 s3e7l als 3e9e6n2 ees aazrns ades 113387 139 320733 - mals2 ss e3l7- ss s3e4l1s9 - wo 116610 162 Z2e0e. 30s 33003.99 amas 3m30ss ssl 34190006 ass --_ 11663 265 30223 sls ee s 31 3 so-ls sa2 z a3 161667 168 BSe9al3s 05 wama ean eselsos maz aanss aus se5. SE 220a00.s7 3wss as 3w2.o0 ss 4m32s ou 20 2 20 20 202: DompanySanitized.Doesrofcanain+ctkcB 524768:OGneneration Reproduction SundRayts Dupon13784 PP a1 20760 REPRODUCTIVE AND FEREILITY. EFFRCTS WITH A-24768 [--; INDIVIDUAL BODY WEIGHTS (5) OF 71 PEALE RATS DURING GESTATION crave: visto nose: 25 osxo/mmY aeSsimer:zon o a wom aimmame, somos omen 16m00 es Wn adeiaeon sadenmos 8awwdla m77 I HBesy MBMeeeos sWdeearsy aaaewss F77i BH3ee0ad5 wa3r3se dddeeasya aaaseeads ii1a Fmi:Ia XEstR2 sA H y2eEnR:e i11n0 Ewo:os dwee:la Fseeiss iass2ls iiianes mBei:lee aab:sd vNeD:sE aahs2ds _ i1ie5 6W:6oo0d2:1 mdea2 sn Waie:sl 115551 FBSoReoRsn CwaEmsRe ddeeels dsaens1s sFe2en 0w.ee4onmms2E ahsNasd aBnNlds 5 2 wT 6? a | "0s otmpanySenSenBistnozteca.ndta.in tacr 124768: OneGeneration Reprodacion Susy in Rats --~ Dupont.13784 APPENDIX M ~ INDIVIDUAL BODY WEIGHT GAINS OF P; FEMALE RATS DURING GESTATION | | i| | || OOOO | "24 | Company Saniized. Doss not contain TSCA cB 24765:OneGeneration Reproduction Study in Rats DuPont13784 --~ INDIVIDUAL BODY WEIGHT GAINS OF Py FEMALE RATS DURING GESTATION EXPLANATORY NOTES Note "NTohisgeasptpaetniodnixdactoantwaeirnescdoaltlaecftreodmffoermfaelmeaslewsitwhitehvindoenecveidoefnccoepouflactoipounlaotbisoenrv(edw.hether a liter was delivered or not). Abbreviations G NLD = = GEevsitdaetnicoen of copulation observedbutno litter delivered; data excluded from statistical analyses. - = NoDaa `SSuDm.mar=y SeScttainodnard Deviation SE. = Standard Error N= Numberin Group -- S20L s- FA ---- EompanySaniized.Dossnot cantain Tsca cay H24768: One-Generation Reproduction Study in Rats DuPont13784 -- 56 24768 ] REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24760 (--) B0DY WEIGHT GAINS (3) OF P1 FEMALE RATS DURING GESTATION Rove: 11-0 DOSE: 0 UG/KG/DAY aDasATYaST:ION 01 76 em om asmmamas ANDIAL NOHBER 00%1 32.170 23.000 1s0e7zs 1s3lss 10905 335ss 324022 s7r0 11s07 101021 33900s3 2198035 0s0el9s 1125083s 110038 3s4i3s 329205 e7a6s7 asaiis 11005 2a5l4s 33132 ssesoo s1l6s22 107 1s 02 ais 6s wp 110089 a32l0s0 2220083 ase3s e12lss 11m01 $S7a 230a aeeis 12a 903 wo 23 1 3 a3llss eaz sZsa --_ 1s 1116s aal7a 3000 322320 36s ee9l3o2 1sase 72 1907 718 19 aa1z 2a617 73a95 1a0n10s2 nl 1s sez 1310 120 - - - - w5e.a HES w3s 21635 eslss 1a2s1s6 22 21 e193 2 2 22 2 Animal delivered prior to collection of Day 216 data. 206CompanySaniized.Doesnotcontain TSCACBI 276: On rion Eton sy ne ors ~ [EE ------ SII... 2 ve 0. rs som su J J sn sn,wane { | || Company Sanitized. Doesnot contain TSCACBI HL24768: One-GeneratonReproduction StuindRatys DuPont13784 ~ [ --_ REPRODUCTIVE AND FERTILITY SFFECTS WITH H-24768 TADIVIDUML BODY WEIGH GAINS (g) OF PL FENALE RATS DURING GESTATION Grove: vI-0 DOSE: 10 MG/KG/DAY GesDATYaST:Ion 07 um wean on mSmoaoss AL ER 11456 Fr nWae . eamas 2 2s0-e9 w2ean = mo 141089 150 $B2o 30 221s ea 0 mo ea 1is3e ie 115512 153 s-da 32a 350i w:a ws as= a iso is15a5 158 B3as 23 2a0e als asssos ao iamniss im: 115578 159 wBaa 2 naln - earpn - ams=is uo 161610 162 230 $6 22.s6 ls 2 dn 763 1sss add 116638 165 B2s ss d=e 21s m>a s~s ser 27 116667 B31a 3mlae ssoeaz 1siss 168 az 3 ena iol rm5a. 3S9s 2ow65 7ms2 1a34n8 Sx E 203 2023 207s 20sl | I . "208CompanySaniDoetsniotczonteaindTS.CA C51 24768: One.Generation Reproduction StiundRayts DuPont 13784 oo 50 20768 `REPRODUCTIVE AND FERTILITY EFFECTS WITH H-20768 (--) 20DY WEIGHT GAINS (3) OF P1 FEMALE RATS DURING GESTATION Grove: VIII-0 DOSE: 25 MG/KG/DAY aesamvasT:ION 07 74 ua on asmamrvs ADL NOUBER 116790 0 308 1aials 7ee3ls 1110a1 11mm 27lo 21s 9e6z7 1157333 11773 23033 23577 ssazs s1aas 1177s6 32512 28112 7s9lss 1sl7s m178 G3l0s 229605s osissa 11e6s02 118709 27-.7 2-s s-na 7-s 181821 2-3 2-8s s-ls - le 118836 2-.6 3-0 9-2a 153-.4 118856 62.506 236.00 sesa 113870.30 Ps = wien wz ama 1189s0 23055.80 220577 s8e9s0 u14a3s 119912 a2628 231s6 7m7a 113a8s f5o.0. . wsz ass3 2a2s3 ssasz 13sl3s 20Ts 2011 201s 202h "2m[EompanySanitized. Doesnotcontain TSCACBI H-24768:OneGeneration Reproduction Study in Rats -- DuPont13784 APPENDIX N --_ INDIVIDUAL BODY WEIGHTS OF P, FEMALE RATS DURING LACTATION --~ . TT || ompanySanitized. DossnotcontainTSCAC!" | 24768:OneGeneration Reproduction Study in Rats DuPont13784 ~~ INDIVIDUAL BODY WEIGHTS OF P; FEMALE RATS DURING LACTATION EXPLANATORY NOTES Notes Unless stated otherwise, animals with no data did not delivera litter and therefore had no lactation data collected. Test days for animal fates are determined from the initiationoftest substance administration. Abbreviations SD = Sacrificed by Design = NoDaa `Summary Section SD. = Standard Deviation SE. = Standard Error N= Numberin Group -- | | FE | CompanySanitzed.Doesnotcontain TSCACBI H-24768: OneGenerationReproduction StudyinRats DuPont13784 - sv 24768 7 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 (@ i 0... BODY WEIGHTS (g) OF P1 FEMALE RATS DURING LACTATION GROUP: 11-0 DOSE: 0 MG/KG/DAY. LADCaTsA:TION o a Amo NomER El 323.9 3.5 sp (av 100) 5 336.3 35.5 sD (OAY 110) 5 339.2 381.0 sp (AY 102) 100 35.9 360.1 SD (BAY 106) 101 320.0 336.4 sp (AY 100) 102 3207 36.0 sp (AY 101) 103 35.2 Ms. sp (oAY 102) 100 347.5 3600.6 sp (AY 103) 105 326.0 346.6 SD (DAY 106) 106 336.6 336.3 sD (DAY 200) 07 - - 0 ((oaarx 107107) 108 341.5 367.8 sp (AY 100) 109 280.8 308.2 sD (AY 201) 10 343.5 360.9 SD (DAY 103) m - - so (oaY 108) m es 32a sp (ay 108) m 326.7 3321 sD (AY 100) 14 386.3 390.1 sD (AY 108) 1s 33.1 357.7 sp (oaY 103) 116 305.2 320.9 sD (0AY 101) mw 32.8 344.8 SD (AY 101) 18 315.0 335s oAY 203) 1s 307.2 366.0 sD oAY 201) : 120 30.8 357.9 sD (oa 100) : | |~ . | an: | Bompany Sanitized.Dossnotcontarn Tse car F24768: OneGenerationReproduction SudyinRas DuPont13784 --_ [Tec us 24758 REPRODUCTIVE AND PERTILITY rs ss EFFECTS WITH H-24768 Grove: 1v-0 DOSE: 1 MG/KG/DAY saacmvasr:ion . nos women m ses as.z sow 10m 12 uss sz so ow 102) 12 wa nee sow 100) 126 M24 sas so ow 100) 12s w1s 3e.4 sway 101) 126 nos se sp oa 103) wr - - 5 ony 100) 126 amo amas oar aon 129 362 200s Gav 10m) 130 aro asa os oar on) --_ mm me mss oar 100) PY 02 5.0 soar 103) m su. 3.9 soar 20m) 14 ser was oar om) ns sm. ame sp oar 20m) 136 68 65.8 sD (ow 100) 7 2a m1 sp war 100 1s - - > (oar 100) 1 we ams os oar en 10 - - > oar 120) 10 ses es so oar 100) 10 347 aoa soar 0m) 10 377 6 so oar 103) Tee 316.7 316.6 SD (DAY 202) -- -- BompanySanitized. DonotecontsainTsca car H24768: One.GenerationReproduction Studyin Rats Dupont13784 - [i ss 20768 ) REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 ---) _-- B0DY WEIGHTS (3) OF PL FEMALE RATS DURING LACTATION aRovR: VI-0 DOSE: 10 MG/KG/DAY wTaacvmsa:ron . nos wows --_ |: 245 246 -ss mus 50 av 100) so mario 10 10 -. 2.4 363 50 way 107) sp oar 02) 209 150 ss. va asa wes sp GAY soar 01) 101) 15 152 -ma mos s wax 10m) so oar 03) 15 130 dea mss aaassso Gar GAY 03) 103) 155 136 vos 322 d sesess ax Gar on) 102) 157 150 05 s! ss wax oar 108) 00 159 160 sz amas GAY 0D) nus zs GAY 0 10 12 320 amis ws 6s. so oar 03) s GAY 10D) 0 Po sea - az - so 5 aren onx 10m) 265 266 w65 nea eMzasso GAY oar 101) 03) 297 aoa 38s Gar 108) 168 342.6 364.47 SD (DAY 102) --~ - ns Eompany `SaniSanDiootsnioztceondta.inTscacai H24768: OneGenerationReproduStcudtyiinRoatns Dupont13784 DUEL... i 3 sms sat --_ 4s 24768 1 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 Rove: vIII-0 DOSE: 25 MG/KG/DAY saacmvaer:zon o s rp 168 0 29.7 a1 36 ams so owx 10m) so oAY 10) m wea wna sp wax 10m) m m se wee wes 30.3 soar 103) Sp oAY 100) v17s4 Jes 8s onx 109) saa 37 sp oar 100) 16 m nse wa amo uss so wax 109) so owx lon) --_ 169 aaa - sz - sp > oAY oar 109) 10m) 100 0 we 20.4 ws 36.6 soar sp omy 01) 103) 102 0 217 seo wea se som 103) sp oa 100) 104 -- ax 10m) 105 106 ws9 wea a354.m9 assp AY ow 103) 100) 107 205.7 Mes sp AY 01) 108 109 wa ss 9 32s4ssoGaaro0nm)) 190 0 a0 sze s21assSoGaarvloen) 1 ma ams soar) - | |~ : | --_-- CompanySaniized. Does not contain TSCA CB H-24768: OneGeneration Reproduction Study in Rats --~ DuPont-13784 APPENDIX O --~ INDIVIDUAL BODY WEIGHT GAINS OF P, FEMALE RATS DURING LACTATION --~ . . | 216 | Company Sanitized. Does not contain TSCA CBI Pe. 124768: One Generuion Reproduction Study in Rats Dupont13784 INDIVIDUAL BODY WEIGHT GAINS OF P; FEMALE RATS DURING LACTATION EXPLANATORY NOTES Notes `Unless stated otherwise, animals with no data did not delivera litter and therefore had no lactation data collected. Abbreviations - = No Data Summary Section SD. = Standard Deviation SE. = Standard Error N = Number in Group --_ | || --_ . --_-- . `Company Sanitized. Does not contain TSCA CBI F-24768: One-Generaton Reproduction Sudy in Rats Depont-13784 ~ sv 24768 1 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 [o-- 50DY WEIGHT GAINS (5) OF PL FEMALE RATS DURING LACTATION Grove: 11-0 DOSE: 0 MG/KG/DAY avs. oa nm wpe 0" 16.0 2 uz 59 we 200 12 101 14 10 23 100 20.7 108 or 205 20.6 206 "0.2 -- 207 - 100 20.3 109 24 110 1a m m I mw st 1 ne ns pr 116 2.7 i wr 2.0 110 2. us "0.8 - 120 10.1 - -- Company Seniized.DonotecontsainTSCA CBI 24768: OneGeneration ReprodSutucdtyiinRoatns Dupo 13784 --_ I24758 ) REPRODUCTIVE AND FERTILITY EFFECTS WITH K-24768 _-- BODY WEIGHT GAINS (g) OF P1 FEMALE RATS DURING LACTATION GRovR: TV-0 DOSE: 1 MG/KG/DAY LaacvasT:Ion oa no wOmER m 2 0w.g7 3 "2 120 2.1 125 10.5 126 5.4 127 128 12 1s 3.8 130 na --_ 131 as 1m a2 133 5.6 10 15.6 ns 38 136 0 7 "6 ns : 139 10.2 240 - wm 2.0 12 1.7 ws 5.9 144 "ou | |~ : - ETH CompanySanitized.Does notcontain TSCA CB! 124768: OneGeneratioRenproductionStudyinRats Dupont13784 ~~ f us 24760 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 . BODY WEIGHT GAINS (g) OF P1 PEALE RNS DURING LACTATION Grou: vI-0 DOSE: 10 MG/KG/DAY sacimierzon os mos, wom was - 106 1.6 110s 10. 115000 1sas 151 : 11552 w"0o.6 --~ pe 155 0E.n0 156 10. 115 36.0 116509 020.27 10 1s 11062 55 or : 11065s w10.e2 | 0 00 n1e t --~ . Z- [Eompany Sanitized. Doesnot contain TSCA CBI H24765: One.GenerationReproduction StudyinRats Dupont13784 L i 20768 1 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 INDIVIDUAL BODY WEIGHT GAINS (9) OF PL FEMALE RATS DURING LACTATION GROUP: VIII-0 DOSE: 25 MG/KG/DAY aceoes: o ot mo wom --_ 10 2.4 mm0 1296..65 m 0.6 11m7a 2r6.y0 ms se i1m6 112a 1m7e9 sBe 100 ne p1r2y w6.z0 110003 15.4 11956 c1.0 100 2n.a8 1100 nPRs m1 a 192 20.5 - || |~ : | En | Company Sanitized. Doss notcontainTSCACBI H24768: OneGeneruion Reprodction Sy in Rs --_ Dupo 13784 APPENDIX P ~ INDIVIDUAL FOOD CONSUMPTION BY P; MALE RATS DURING PREMATING _-- || Company Sanitized. Doesnot contain TSCA CBI 24768:OneGeneration Reproduction Study in Rats DuPont13784 --_ INDIVIDUAL FOOD CONSUMPTION BY Py MALE RATS DURING PREMATING EXPLANATORY NOTES Notes TestDays 1-73 = Test Days 73-87 = TestDay7l = Premating period Cohabitation period Last day of premating period that data were recorded. Abbreviations Summary Section SD. = Standard Deviation SE. = Standard Error N= Numberin Group --_~ ~ : | Tm p---- | GompanySanftized.DoesnotcontainTSCA CBI H24768: One-Generation Reproduction StudyinRats DuPont 13784 --_ fi 5s 24768 ] REPRODUCTIVE AND FERTILITY EFFECTS WITH H-20768 Lo VIDUAL FOOD CONSUMPTION (3/day) BY PL MALE RATS DURING PREMATING Rove: 1-0 Dose: 0 MG/KG/DAY onoTaEvSsT: 18 eas 15-22 2228 283 36-43 4350 AL EER z1 3 a26s.3 372 m26s6 en m28s4 mo 22870 2907 3292.7 32s 2390015 30s 03.s0 4 5i : 230a2 le eeon zea 2m6s7 ma 2as4s m2 228907 32 228131 3 623873 57 5 Z0oo foe A ddarse amdiooss saallrsse amasasl aemsiisoa az1s5eh3 n0 In 23065 201 a 3s 4s s35es sas a2ssl 267 0zz4 260 2e9e4 261 22882 261 b1o 1 32640 33 d23e. 2 mmo2 Zo aa2e als a29l0s1 zl 2m8s3 mz 220520 263 n1 10 3Iso BG Ramss ME a as ms 2o4s0: as 2s6es mls e0s mn mmaa ma ~ 2I0 2 II300s65 asllos dle 2Z2e aes asjllooss saiese zs 2e8n0 ae 2a4saa as 12 2 Z3e5e fs aBel 2 amai N32 aaras me 2a1s2s ma aasileo wz aas0s 210 SEoa.n Six 226120 Gi 2B6a3 oa 2B3n os 2B1a oa mGsn os 2hsh ols 2h6ns oh w 20 2 2 2 20 20 2 Te CompanySanized.Doosnotcontain TSCA CBI HL24768:OneGeneration Reproduction Study i Rats DuPont13784 --_ (i st 20768 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 --- 00D CONSTMPTION (3/day) BY P1 MALE RATS DURING PREATING Rove: 1-0 DOSE: 0 WO/KG/OAY onomneset: sess ses em 1m mos ome 21 5 32.35 21 m3as 26 m2.a4 2s a2s9s0 aso 35 : i2s0 297 2252 m0 aalss sie a2s2 304 7: 5 aGsl5o es 3W2os 267 0 3s m4 ma3s mi 1112 3 2a ia mmlos gee amsss 3s a2ri0s sls 113s ZB1iias aail2es a3ms7ao aa2s 26s 11 Z9a8o 2045 226a0 20068 ~~ 118 20 223s Zo z20:o1 amess 298 a2sss 20 22 2 ZZso I awmsa ea maos aes aaees 262 2 35 me ms aa 5o.y 5 6e9s 15 2B0n 05 z2a os 2B3i ou 20 2 20 2% | --_ . . mse "CompanySanitized,Doesnotconte 7S~A 231 F-24768: One-GeneraionReproductionStudyinRats DuPont.13784 ~ 5is 24760 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24760 (i)... 00D CONSUMPTION (g/day) BY PI NALE RATS DURING BREMATING aRovP: 111-0 Dose: 1 MG/KG/DAY on TEST: 18 eds 1522 2228 28-36 36-43 43-50 ANTAL MEER 226 zn 22330.73 2a0 s23e.s5 262 e24s1 255 m20s9 260 22.840 27.6 m25o.5 26 2267.18 247 220 30 3Z0e0. 263 2253.s3 26 02659 281 221638 02 229713s 27a i 262 273 232s 273 322 3 33627s 30s amsys 2s2 32:633 261 m26s 284 3227s5 ass masoia 251 2a2l sls 335 36 Z3e67s 2300 m2s7i7 za 20615 a1 2288. 291 2a8s 3200 2w9s3 304 22178a 21 33 39 222005 235 maezs 3s massa 32s 228s0 a0 22806 m2 22710 ls 22:604 3h a0 2 2S90036 a0 322906 20.2 a3e0s 29s 32920ss 313 029006 02 229402 298 3281.44 292 - 55a 22770s 338 amsss as3 222s93 222686538 226872 27s 22890 26 22719s 247 ao6n 226647 336 masss 4 w2i6s0 ls 226686 30s 2282.4 30a 228635 323 228731 3206 A 5.0. SE 226.44 5s 272.s1 os 2a0l.s0 os 22871 os 282.39 os 228a2 os 272.a9 os h 2 2 2 2 2 20 2 -- . . 26`ompany Sanltized. Doesnotcontain TSCACBI | H24768:OneGeneration Reproduction Study in Rts DuPont 13784 --_ f 5s 24768 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 --- 00D CONSUMPTION (3/day) BY PL MALE RATS DURING PREMATING Grove: 111-0 DOSE: 1 O/KO/DAY ouaTsEST: so-s56 S663 637 1m DAL NOEER 2256 2 23s 265 2m833 ae 2248 ao 2s6a6 ale 22s 3 230675 Is 0ml7s 0s 22s1 2 2 es as 32a B25601 s2a5z aasss a28e1 2s 253 27 2s 33a 2I03 a0w8a m2s3 a2r0s0 3n6 Z2e0e3 aas2s 2m6s 2002 33a89 33B02a75 msma72s mmmoas 2m1s als aa i 259072 35 3m0lss 293 2a99s aed 2306s 2a --~ iiass BIiE amlss aa2s salss 35 ms aes 2 aa 3B3a mao wmra lass rsmoa. 0215 225 m2e3 22s3 xSE 2Gs 2os 2os 200 | || ~~ : | | - `Eotmpany Sanitized. Doesnotcontain TSCAC51 124768 OneGeneration Reproduction StinRyat Duron -- (i ii 1 REPRODUCTIVE AD FERTILITY EFFECES WIR H-24768 BIL. cocoon i mono vs sm noc amcor v-0 JU I.ows ve eas asm mas ae ses ees awn sma "22 mnedsioEaa173 mmBayioBahl1s mnhsse ommwiss aRxaId 38a 1 mnaooa mmi BRRYnsooRBmdioonEmiid BnBiyt e3Rsi i55% Mmeeso Rdnsono nkoSmnomownid 3mBEe BoButds nB3ii3 a53 Bnmyiioonommsee BmWMaso oBRMiiioomlmie oBBn@ni RBBiII aaa RHBsyeoomoBomisao moo3mm3oRER3is BomReo: HEmSyinRnsas aoH RH3ee8oo3WWmisooEmmnse oxkonnm mkonsie BnBes snNnsd --~ s&a IBB3e0Bsdmea omm mse Bkmse onomRia BEBmDS BnBlas 23 mBRy3o0romioEmm 3t ndBds nBHoiomouins omnRid wixw ws0s3 sammae wWwae omwae0 mousmi mooeaTd aoosma : 0 at at a a a a | -- . ------L 24765; One GenerationRegrodacion SuidnRasts DuPone 13784 _ fi us 20768 RSFRODUCEIVE AD SERGILITY EFFECTS VITA K-24760 -) 000 CONSTHFTION (3/day) BY PL YALE RATS DURING TREATING anon: v-0 o-- arotwes: sos see em am nv omen i" i BB02iioonnm::s namneo Ba2Ses #3 We an mo iii H BBHnoioo@RneEn aaBsnn aBaosn Be mi B30 H55f h BeoaionoBn kBoaann waasds &a@ #3B3owaknei mBBpeE mooasnd &a8 BB BiEBo%shne wBk3ne0 aaaeo -- Gaa mB#y3ioRkm3En oaBnme RBasd 6 n3oome ge ad ia5% EmBEeeS mdeis BdSnsC B3n0 w5oa5t wcSsee wwSofe ma4an1 aausds i 2 a at al ET Company Saitzsd.Dossnot contin TSCACE H24768: OneGenerationReproduction SudyinRats Dupont13764 ~ [ s 2760 REFRODCIIVE AND FERTILITY EFFECTS WITH H-24768 a FOOD CONSUMPTION (9/day) BY P1 MALE RATS DURING PRENATING cous: viz-0 Dose: 25 w/K0/DAY onozarese: 18 sas 1a 2220 236 36) 4-50 mo woe 77s ma FOsC mS2n 2BS33E03 mBS aE GmhlasSEm3 alas n<s3sh) 7778 32B0s23a disanea eBasGe aGmsass sbaellaas ze2e8an3 seallaso 7a& aaZae ddkeasos ea301s aabihea 0ele2sl mzielsase 2200018 255 MBBnolodkeo BBmsIe aGmesas ob1eas aBmisln a n2a% 552 33Z06e0 GGSeezsn Glkles deNellSs moda2sp ma3e0ass 0wsn ai5 3Z20s5 mfaesazi madsuz p2san 2m1aam aajaoa0s mamla0s !--_ p55y 3I Ba7 5 aSmoae whmssh am3oi1 maaa3l asaomona ammisos 555% aB fr a: Bdess MBRlSes 3Wom2ea amRlmsIORibLlns zBOEasD spEmyS 2ZGaSionmwssl mBoses aoBons mBaonk mBa2ER2Goals a' wt wt a at al ow | |~ -_-- . =m {EompanySanhized.Doesnotcontain TSCA CE 24768:One GenerationReproduction SwdyinRats ____ DuPoncl3784, --_ [ ss 2060 1 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 _-- FOOD CONSUMPTION (g/day) BY PL MALE RATS DURING PREONTING a Group: vI1-0 e bose:e25 Ma/KG/DAY AD onoTnEsST ose sem oan 1m nnn womER I77s PSJoroa aBEe 23677 a mh 77Ww ZZaoena hsdaissn mm3naa maaesasi aIas 3I 301 dhdiess mBmaoa 2aslosn 2aa BBBaaao ldpaeas 2awssl aaasel a58 BBBoaa mwoe doe mmllss a1 3m9hs 30s 5b5e fFSEio aes me maz ml ma 29s --_ p52it w32a33 mmhses aahemo saaeuors 555 BfB3or0s I dnnn hmBllns aaSe0ss sSmfiasa a2FRsI a2mmo mKB21A0 2T0a 2 at wt ow -- Ee CompanySanitized. Doesnotcontain TSCA CBI H-24768: One-Generation Reproducion Study in Rats DuPont13784 APPENDIX Q INDIVIDUAL FOOD CONSUMPTION BY Py FEMALE RATS DURING PREMATING || ~ - | Te | Eompany Sanfized. Dossnot contalhTSCA Csi 'H24768: One-Generaion Reproduction Studyi Rats DuPont13784 - INDIVIDUAL FOOD CONSUMPTION BY Py FEMALE RATS DURING PREMATING EXPLANATORY NOTES Note TestDay7l = Last day of premating period that data were recorded. Abbreviations `Summary Section SD. = Standard Deviation SE. = Standard Error N= Numberin Group -- ~ . = --_-- Company Sanitized.DonotscontsainTSCACB! H-24768: OneGeneration Reproduction StiundRayts DuPont13784 --_~ 0 5s 24768 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-20768 (1. FOOD CONSUMPTION (g/day) BY P1 FEMALE RATS DURING BREATING Rove: 11-0 DOSE: 0 MG/KG/DAY ono1a8rSsT: 18 sas 1522 22-28 2836 36-43 43-50 ATL NOEER 058 110.s9 2116.84 2m0i7o 2s0l8s 21908 220054 2110s1 10505 l20o0 120010 i1s8l0a liasaa a1e8s7 2108038 1170 1002 T1e3z 11009a 1sl2o 1a8s0s3 2a0s2s 1a85ss 2190020 110038 a20701 210075 i1sl2e a1sisa 1s8l3o zaa7 210912 10108s 119s7 iIsliss m1i8o3 220000 1i8e2s i1ess 1181s7 110078 a2l0o0 1200079 22010102 2200088 2202588 2205104 2203.44 11003 I2o7 1209028 imsl3e 22000037 1280l5s 12065s8 11983 m12 2I0o0la1 1is3le wissis 129037 a1837 w1a0 1180073 ~~ 131 1s 0 103 1s 12s0l0e2 2s 118s 1s m2025 190s 210807 101 220025 188 1199a7 1909 11mw6 1m7e 1m8l7e 1m8z3 11ss 118035 m1lss 210a0 111189 I1l0os 2m0a3 2m2lae 220286 2m0i0e6 m1i2 21634 120 LR Lr bl 12 des mle 182 P5e. 191.30 131.24 11a3 210s0 1a9a7 12907 1a9l.s SE 203 202 2003 203 202 204 203 --~ | me | TompanySanitized. DoesnotcontTSaCAiCnBI 1247665: One-Generaton ReprodSutucdytiinRoatns DuPont 13784 -- 54 2076 RESRODUCTIVE AND FERTILITY BPPECTS WITH H-24768 [--) FOOD CONSTUPTION (g/day) BY P1 FEMALE RATS DURING PREGATING cove: 11-0 Dose: 0 Ma/KG/DAY onDraeser: sose se em 1m mo woz 5555 W waae WE wmss haelss ma 19 11001200 Ai1s53o0 mLoaal m21a1%z wn1shs 11100083 BZBroo mBdeaEs akBnS 2Dn0ia0 11100088 H0 wir o1Lwais o1 Bmsa a2n0i3 1011910 11B99a33 3 5 DE 3aD6ss0 asblloes rnmeazl a11a7 ww1ao5 mwwasa 0 11s0 --_ i1s fo a 1 11 a 1 208 mBoso 1 11a3 10 1i13s FmWCeiI a1m5e wmsa a1tst7 sSe5E. 1oe ai s m073 moholn 10M62n wt a? at a | -- . . =e "CompanySanitized.DoesnotcontainTSCA CBI 24768: One-Generation ReproductionStudyinRats `Dupont13784 ~~ (i 5s 24768 1 REPRODUCTIVE AND PERTILITY EFFECTS WITH H-24768 --- FOOD CONSUNPTION (3/dsy) BY PI VEWALE RATS DURING PREANTING Rove: 1v-0 DosE: 1 MO/KO/DAY ouaTvEsST: 1s eas saz 228 2836 36 43-50 RIL OBER mi in wfoel 33 10802 Ba 12091a bis 1m9s3 aes 220061 as 117s3 ams 219sa 16a e1r5t 18 f3o5e fas 2faos as 2b0lse mls mmisr 10 aowsn 208 maess 187 m1as 201 i5e 15 j3e0 $3 aaes fea zaleeaess 2m0i7 wo 232 iin smlss 1s m11s6s 1330 3 3 1% jo 1 204 22 amu7s me l20n1 az 2i10 an 210a0 as 21308 mz 33 135 5 Ia 105 2B0e 22 Basisl as 2l0i6 ms 1b8h7 26s 2w1e3a 238 w20ls a 13e6d 36 3fe57 Io alass dss soaos dss a1s9ss 203 212.84 223 2032 aa m20a2 als ~~ 11309 1a 1$85 I 11ss 130 ow;13 2007 smss 2005 z1isasla emzs a 1a:2b 10 1103 10 I 5 3 1d3oso fs mdesls al 210a3 ws zslss ah 919s0 ws q1e4 20 wxsSieoen. 210T28s3 12h0.e%8 12ma9is9 22Bo0n3s 22Go0ns7 22Go0.kk0 22uo0lh3s -- . . rer ------------------Eprimreeset "CompanySaniized.Does notconTtSaCAiCEn! H24768: One-GeneratonReproduction StudyinRats DuPont13784 Pe. st 24768 1 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 (a FOOD CONSTUPTION (g/day) BY PL FENALE RATS DURDNG BREMATING Group: 1-0 Dose: 1 MO/KO/DAY onaTEsST: so-s6 see) 6371 1-71 nL NBER 1m2 123 B10e 5 m11lh3e wl2m 2e a1 19as 182a5 138 B3310 We mBlhe 11 walos sls m1ia 1s ` 3Ee8 129 D##o85 1 20 I ma3a 12 w20a0 aes 11530 132 6 va 5 1a9z0 21 ma2s nl 2102 ma 131305 135 Gfleo 35 aDsh als ma27 als 2s3s 20s 131367 8 #W#31151mm53s mas2 22 2m0s as -- r116i309s f3dl5aa eemllzee m2a0 11 11803 1903 p1r2 pr 223s Lh Balsa 20a mmha 2002 1 200s 200 we5ap ps 12s2 03 aG0n os mGal ols 2i03 ola | x 2 20 2 20 - `GompanySanhized.DoesnotcontainTSCACBI H-24768: One-Generation Reproduction StuinRdatys DuPont13764 ~ 5s 24768 ] REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 (m--] 00D CONSUMPTION (3/day) BY 1 FEMALS RATS DURING PREMATING Grove: vI-0 DOSE: 10 MO/KG/DAY. onavTsES.T: 1s sas 1522 2228 28-36 36-43 43-50 ANDO NUMBER 116685 107 117023 ire lmeala iso lms2 2008 i1eas 2014 i1s6s6 1803 e18z3 197 116090 2003 11669 150 f2e176 192 2 211 216 lms0 204 a2024 208 22025 213 22a21s87s 12502 23 1m512 15 D2121 fai a2l3ss isl7 amliso 203 2a05ss 203 221480 200 a21l48s1s 2224s 9 131585 156 21090s0 196 119262 isla 211937 as 29386 203 22a00s22s 2n0.74 a 220025 sls 115587 159 ileess 233 2107080 341 e11s7 28s 220:000 266 119938 263 11845 215 113609 261 16160 162 153s4 1308 18722 2008 3ow0l6s 2:6 1168s0 aa 694s 237 1188023 2004 120as 216 -- 161683 165 11i43s36s 2129006 13 weise we1 120a4 13 21001 1s 2e0z8 187 11875 100 111666788 15s 14 mmliss 208 wwisr as i20s05 12 a3ls 2 2132 2007 12eis2 1906 5.e0n. sz 1236 G4 12917 0 21s 04 220a2 os 220a3 os 202.s0 os 2200.68 N 2 2 2 20 20 2 2 --_ . . 2: CompanySanitized. DoesnotcontainTSCA CBI H24768:OneGenerationReproductionSudyinRets __ DuPonela784. --_ [i uu 2075 ) REPRODUCTIVE AND FERTILITY SEFECTS WITH H-24768 -_) FOOD CONSTNPTION (g/day) BY FL FEMALE RATS DURING SRENTING eecroup: vi-0 D-- ose: 10 wo/xo/DAY onnnaasse: ses6 see em 1m sino ome 11w83r8 13 9633 weaasa dm20oa5s 1l198s03 b11r560 3Dji6ss sBaesene zm Gaes 3; a1lhs fe31t5 B3 f3e0 Bmmnol Emwphea aa1ass 115556 2i0a30 addmleeaa 22 d0s 21s0l0ss7 115515758 Zffooos eZ19sos wmaeoas 1s2sls 111666012 IFrs Foc 7A S de t 1a4r1o --_ 11616685 J9 foass 23 d0ess aBm0Ia 1D280h24 111666768 4 hWeaba was akmzsinalsse mSaE5. 12Gs35 ooBmsaa mahssn 2Go0ah2 20 22 ad 2% | mre-- re re----aeeeeoe eeeeeeeeemeste ee s err er ees P | Company Sanfiized.Does not contain TSCA CBI H-24768:OneGeneration Reproduction Study inRats DuPont 13784 /~, I i 2068 1 REPRODUCTIVE AND FERTILITY SPFBCTS WITH H-24768 INDIVIDUAL 00D CONSUMPTION (g/day) BY P1 FEMALS RATS DURING PRENNTING Grove: vIIT-0 DOSE: 25 MO/KG/DAY onDTaEsST 1 seis 15:2 2228 2836 36-63 43-50 ANDO VOHBER 161790 im 1B.G0 163 2a0z7 203 o0.m8a Ble 2190.76 2001 1as8i.n6 1s 220001 isl 1a637 20.8 m72 7m 1fe93 167 217s las meos 19 m16a9 1s o18z3s gen 22049 199 a20s6 202 117756 71 i20e0s0 fe 11920s 1s a1o9s8 ws 116335 ma 11390033 ies 2m0027 12 119s8 20 171789 180 iisses 205 1lasn 20 a1l3o m0 1197a 204 1208035 2008 21920ss 218 11949 22s 1011205 D18200 187 2a0es 7 mmns lls m201s 2a was1 201 2204 2 2a008s 200 118550 136 2fe7o 2008 0le7a awa m16e2 as aess aa 1m73s 20a 1om9as m1lss alo; -- 0138 189 I2o0 De 3 as bi Aass bls m27o Ds m22a Bh aa0s wl aalss 1h 219901 192 ZDs1 As 2o00ss ma 1a3s2 a1 lwena wz 2mas zi 2alss =o m19os 2a r5ma.n sz 191.s0 04 20U.s0 03 20A.n4 0% 19M.r5 oa 2T0e2 03 20i.s7 20i.s5 03 oo x 24 20 2 2 20 20 2 | 20: | EompanySanitized.Doesnotcontain TSCACBI H-24768: OneGeneration Reproduction Study in Rats DuPon-13784 --_ i 5 24768 1 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 INDIVIDUAL FOOD CONSUMPTION (g/day) BY PL FEMALE RATS DURING PRENATING Rove: vITI-0 D0SE: 25 MG/KG/DAY onaTvEsST: s0-56 se-63 em am ANDOL NBER 161709 m 219a.0 119933 22010 21090.46 Joa 2:0 2 200 mim3 178 Z3o2s mmiza 2201s 21037 feo 205s 2s 1903 171765 im 1122 21132 2a00us 1s8l%s 13 les ws aes 17189 180 a1179s05 11s7 oar 2u00s7 mo 1a8e%s al 11882 183 2Z0o3 D5 22D:0i04s 1m62s wa 2a023 wa 11885 188 210s5 f8 a1asa 23 mlas ms 21837 al --~ 11188898 21070 mr 220080 wa 2a0s07 wo 220s4 us 19fe0os 192 11001 210928 2210s5 22000409 17 20 al al Hes5l nz. 21019.4%8 22020373 22200a48 220001.222 --_ . | | . Tans Companysanitized.DoesnotcontainTSCA CBI 124768: OneGenerstion Reproduction Sudy in Rats --_ Dupont13784 APPENDIX R --~ INDIVIDUAL FOOD CONSUMPTION BY P, FEMALE RATS DURING GESTATION | --_-- =m Bompany Sanizec. boss not contain sca caf 124768:OneGeneraion Reproduction Sd in Rats Dupo 13784 --_ INDIVIDUAL FOOD CONSUMPTION BY P; FEMALE RATS DURING GESTATION EXPLANATORY NOTES Note `This appendix contains data from females with evidence of copulation observed. No gestation data were collected for females with no evidenceofcopulation (whether a litter was delivered or not). Abbreviations G = Gestation NLD = Evidence of copulation observed but no litter delivered; data excluded from statistical analyses. - = NoData Summary Section SD. = Standard Deviation -- SE. = Standard Error N = Number in Group || --~ EE Lompany Sanized. bossnotcontain sc. 1.24768: One-GeneratonReproduction StudyinRats Dupont 13784 --_ ss 24768 1 REPRODUCTIVE AMD PERTILITY EFFECTS WITH H-24768 i)SUL FOOD CONSUMPTION (g/day) BY PL FEMALE RATS DURING GESTATION anoue: 11-0 DosE: 0 MG/KG/DAY GESaTvAeTI.ON 07 7 we om aEmmarovs Ano woe 057 m2s3 mde0a 2I47 22 10509 225s0 2256a 22318 22s1 102002 2m0z1 22473 2as4l8o 2223 110038 2B0s 2d5s1 2m0a8 223a3 110056 22610 22s1 2m20 22410 101078 2Zss amlay 2a0n1 220a wo 10190 226602 225ss 2201 224681 mhl mlio m2las uaa aas wo 11m5 2ss mo 262 2m13 2z6la --_ 1156 mslos aslas aass salrse 11m8 63335 2233a3 al0s 2226 1209 325 e<a 25a 26s w5ma. 2d6s 2250 2G3h9 2a0hs uSE 210 23os 2om 2os ~~ . || a 7ainal delivered prior to collection of Day 21G data | Tas Company SeniDtoeisnzotecondta.inTscacar H-24768: OneGeneration Reproduction StudyinRats DuPon-13784 ~ 5s 24768 1 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 (-- 00D CONSUMPTION (g/day) BY P1 FEMALE RATS DURING GESTATION Grove: 1V-0 DOSE: 1 MG/KG/DAY casAmvasT:IoN 01 14 wen om samarmus ANDI FOE 1m22 123 2m6l.s9 203 2206s4 24 2211.39 ma a2l7s1 al 121285 126 220s2 2s 2212s 207 2alas ass 22206s 247 1f2e8d 129 226510 25 22625 201 allesn 306 225a3 257 mo fe13i0 132 2258s 236028 a2s3l3o 22517s 333 a7 als 303 133 3s 3280%5 226638 228009 22612 305 308 ala 34s 113m6 138 22658 2a679 w23i1ss 22810s9 ass sls m2 247 xo ~ 114309 ris 2m0l3s 120aa melsso daass 2802 268 2907 22 wo 114632 168 221878 220125 2266004 22465065 2603 258 26.4 26.2 sDn.n sz 232.43 22680 298a2 263.15 os os 1s 0s x 20 20 2 2 L~ . | | 2s | CompanySanitized. DoesnotcontTSaCAiCBnI H24768: OneGenerationReproductionStudyinRts Dupont13784 --_ fi 44 20768 REPRODUCTIVE AND FERSILITY BPFBCTS WITH H-24760 _--). FOOD CONSUMPTION (g/day) BY 1 FRIALS RATS DIRING GESTATION Grove: vi-o Sos: 20 Wok/DAY csamiiez:on or 7a wm om sSnaamroe mons, amen 1iis 3E24eooE1:E2 1m:6ns 2a0`0n wo friia 0 aRsaoE2sSas zmEeae 2aaaadn ii5 sB:iss aE:eD Ra<mDs aa:ina i3iB38 d aSenid ata oh 2aa aBao iii f3`e3o 3d:n0 aa2mmoe mm2as wo iiia dBIoena amhuinns 2mn7nS 3ona2dn ~ iiiea esioa Ea:ise Na`iaIOR2.3a iii WR RE E aM ohn Bhheen bhBnSo saeiEny mwHaeE aaCsO wBKm1Ia0 au1mso H owt wT ow #~ 7oToodt GbaetaEavlecruetanroet.a ctoolrledcatveed 0o.n7.DaFyoi7e,6 iannder0r.o3r1.. thus correct food consumption could | e- | CompanySanitized.Doesnotcontain TSCACBI H-24768: OneGeneration Reproduction Stady in Rats DuPont-13784 --~ I i 206s 1 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 1% 00D CONSUMPTION (3/day) SY PL FEMALE RATS DURING GESTATION Grove: vIII-o DOSE: 25 MO/KO/DAY aeDsATYAST:ION 07 716 em om mstastus IAL NUMBER, 116790 m 5 2s 220s3 220649 220180 28 243 269 253 mm32 178 22s2 22415 2z65 s: 25.4 33 as 268 2807 177ms6 2332 mml3s 2m6s7 2a4l8 Zz mio 213 262 171758 180 2=0 a=es 2-65 28-01 2.0 262 260 25.9 P1Y82 183 3-0 26a 2-58 25-07 %.4 2.5 20.0 207 118885 186 2-67 2>8a 2-63 2=1a i ma wma 22 --_~ 118878 2-66 2s:lz 2ss 262 181590 223.a8 2233.69 220815 224s0 119912 2250.08 22514 226s3 2256027 a 55.05. 210s8 251.s3 216s0 251.24 03 03 03 03 H 20 20 20 20 | = . . 27CompanySanitized.DoesnotcontainTSCA cat H-24768: OneGeneration Reproduction Study in Rats DuPont 13784 --~ APPENDIX INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS IN P; FEMALE RATS DURING PREMATING AND COHABITATION -- -- | as Company Sanitized. Doesnotcontain TSCA -* H24768: OneGeneration Reproduction Study in Rats DuPont. 13784 --_ INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS IN P; FEMALE RATS DURING PREMATING AND COHABITATION EXPLANATORY NOTES Note Days of cohousing for individual females are identified in the Appendix, "Individual Animal Estrous Cycle Stages in P; Female Rats During Premating and Cohabitation." Abbreviation --- = NoData -- -- | Company Sanitized. Doesnotcontain TSCACBI H-24768: One.Generation ReprodSutcudtyiinRoatns DuPont13784 --_ INDIVIDUAL ANIDMUARLINEGSTPRROEUMSATCIYNCGLEANPDARCAOMHEATBEIRTSATIINONP; FEWALE RATS GROVE 11-0: 0 MG/KG/DAY -- anna NUMBER WaOMvBsERoOpF | VEROCFENT PEoRrCENT | PERoCFENT cWrEeANe eRecora DATA DAYS IN DAYS IN DAYS IN LENGTH INTERVAL COLLECTION ESTRUS DIESTRUS BROBSTRUS (days) (days) 9978 320 35078% 3587%% 153%% 6a.l5s0o 110 9100 2236 320388 6558%% 1a9% 4410200 35 110012 222 227788 5s0an8. 253%% 45..0000 22 110034 2232 3a588 664188. 2a3s% 4al2oso 23 110056 2231 328288 567288 202s8 44.0000 31 110078 2212 3237%8 7573%0 100%8 44..5000 21 110190 220a 3358%% 6s58%% 0a8 4al0s0o 1a u12r 2263 2232%8 622088 155%% 5a.l0s0 35 ~ 11113s 2215 31218% 75168% a12s% a4030 15 111156 2231 3B0188 517488 1s83e% 142..0000 31 11178 2232 2335%% 5592%% 1B8Y8 4asl)s 23 112109 2315 333%% a5s2e8 w10s8 44.0000 -1- | --- Ba BNovideevnicdeencofe cofopucloaptuiloantidoentewcatsedf,oubnudtbautnimaallidtitdernowtasddeelliivveerread;litdtaecra.excluded from Stavistical anaiyeis. | Te | EompanySanitized.DoesnotcontainTSCACBI H-24766: OneGeneration Reproduction StudyinRats Dupont 13784 --~ INDIVIDUAL ANIDMUARLINEGSTPRROEUMSATCIYNCGLEANPDARCAOMHEATBEIRTSATIINONPy FEMALE RATS GROUP TV-0: 1 MG/KG/DAY TT AMBmEaR avs oFommor vmooFmnw owercew peoFcaw cmreiws emecormu COLLDEATCATION DEASTSRUISN _DDAIYSSSTRIUNS PDRAOYSSSTRIUNS L(EdNaGysT)H IN(PdEaRysV)AL 21212 222 sat oSsot 3odo 3.50 22 121203 22 193% s7m% 0088 aallor 11 112256 221 20E8y 5on 1m8s asllooo 33 12287 223 as2s 3S99%8 BFy ER eer 33 121390 220 f10e0 oont 0a8 d53o3 31 113312 220 293%a soam s 8 as as 33 1133 223 130908 aor mov alpsi 31 113358 22 32a% 5579% wsw al s.00 2i 7 21 fis san wale 1 . 113398 2n0 asims aann 0o8 do a00 1a 110001 2201 53 39a%n aoo edoeo 81 110623 220 29390% asas 183s asllsoo i3 16 2 a Ex ou doo 2 | a Evidence of copulation detected, but animal did not deliver a litter. | Company5Sa1nltzeid.Doesnoe tcontain TSe CACBI e H-24768:OneGeneration Reproduction StudyinRats DuPont 13784 --_ INDIVIDUAL ANIDMUARLINEGSTPRROEUMSATCIYNCGLEANPDARCAOMHEATBEIRTSATIINONP, FEMALE RATS GROUP VI-0: 10 MG/KG/DAY TTT oMNUnMPsER mavms ooprmonoFn pomromw ow F m wcrwo ue m PRecon rmL COLLDEACTTAION DEASTSRUISN DDIAEYSSTRIUNS PDRAOYESSTRIUNS L(EdNayOsT)H IN(PdEaRysV)AL 110456 223 26100% oone B8y s5.l0o0 51 1487 32s 2678% 754086 30 4a000 z 11560 220 2so0u 5S70%8 mov se alo 2i 151521 32s3 2 saEvy m26o8 aasloo o3e 115543 22 Soau asonn ywn alaeo 3a 115565 222 236600 EsoXn mso alsolo 52 115578 221 1200 soa8n 220%0 aal0oo 2i 115609% 32s 2277 soaunt Ww saooo e2e -- 116621 2213 26148% aan my sdloo 13 163 2 32 EN RE 2 116665 32s2 army as8o m se ae si 7 116667 2235 320880 5s2i8t oy ddoaos 35 168 2 35 EY By doo 3 || B2 NEoveicderevonipcdseeyn;coef docafotpaucolepaxutclilaoutndieoddnetfewrcaotsmedos,btsaebtruitvsetdaincbiaumltalaonndaeildylsniiovste. dfeeltuisverwasa olbistteerrv.ed in utero at |~ | & RNSootaeetvviiisddteeinncccaeel ooaffnacclooyppsuuillsaa.ttiioonn wwaass ffoouunndd bauntd anoliltittetrerwwaassdedleilvievreerde;d.data excluded from ||| ETEa Eompany Sanitzed.DoesnotcontainTSCA CBI 'H:24768: One-Generation Reproduction Study in Rats DuPont-13784 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS IN P; FEMALE RATS DURING PREMATING AND COHABITATION GROUP VIII-0: 25 MG/KG/DAY TT NUMER OF PERCENT DERCENT PERCENT MEAN DAYS OF oF or OF CYCLE PRECOITAL ann DATA DAYS IN DAYS IN DAYS IN LENGTH INTERVAL NUMBER COLLECTION ESTRUS DIESTRUS PROESTRUS (days) (days) 117609 2222 2372%8 5s5a8v a58s 54.23030 22 m17n2 2214 a33w% saase 110388 40000 a1 117734 223 330%8 56718% 1098 300705 31 117765 2214 a33n8 s5a28 153%% 40000 a1 117787, 2224 2338% 50988, 11838% 3l0o7o5 42 181709 2315 2290%8 6178% EENY 44..0205 --1 181 2 25% 08. 25%, loo 118823 2315 252688. 368188 11038% 44.0000 --1 118845* 2335 220288 77418% 9a 47050 --3 --_ 218876 2212 2373%% 582%8 45%8 a30e75 21 118898" 3252 a2s7t% as8e% 95%% 44.20s0 --2 119901 2232 2339%8 577%% a0% 4415000 23 192 23 30% 528 EY 400 3 --_ ab NNoo eevviiddeennccee ooff ccooppuullaattiioonn wwaass ffoouunndd abnudt naolliitttteerrwwaassdedleilvievreerde;d. data excluded from statistical analysis. 253 Company Sanitized. Does not contain TSCA RI H-24768: One-Generation Reproduction Study in Rats --~ DuPont13784 --~ APPENDIX T INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES IN P, FEMALE RATS DURING PREMATING AND COHABITATION | | me Company Sanitized. Does not contain TSCA CR! HL24768:OneGeneration Reproduction Sudy in Rats Dupont13784 -- INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES IN P; FEMALE RATS DURING PREMATING AND COHABITATION EXPLANATORY NOTES Notes TestDay53 = First day of lavage. Empiycells = NoData Abbreviations D = Diestus E = Ess P= Proestrus X= No sample or stage could not be defined from sample. || | | --~ || | 5 TT `Company Sanitized. Does not containTSCA CBI gyJN otiiniznininaiiic SO CCHHAE ~F EC CHCHE 3 ECE CECH 8. |BO | EEE EE | EERE EE | ECE CHCHE EEE g | ECREEE g SNERZENNNNNNRNNNNNNRNRNEEY (eT TT LTed i ER RTT TTT RTE s EIT TTL [TTR olSULTTel 3 RITE |] lel [1lelfao ](J 5, | EH Jeieme|lEleeelllJel Je| 28 [fleece a xa-g-) Zo ZR] Retell Iolela ellcle Re) gy (de RE CeelE ell ~ Bo |x] dei RE = BR co | EL EEE ar | [Elke Ee aleoeo Ca le) aa | [A] EC |l E olaleIsles fl FERRNENN- 25 BEE. -B-BERE- 8B 5 El EEE Ele ER 8 El eRe REE |o ER -RR | 5 Fl QE Ea |e eRe lolol ls Ee flo sl 8 El e-0- Ea EleFE Rss 3 OE [|Eletelelaiele Rs oleae {- SNNEE 58-8 - BREE - - -&- - -EEE j 2 FL RR clo R= EE i: [=| ell =laR a lee lel dz [= RE =lolcl =els Reloale} HIE [Tolle= En lolol ER oe] log E [1 elelel= Ea Relea Eo loEe = go" Io]1 Tel~i e = FR =| CompanySanitized. Does not contain TSCA CBI . i : i 3 :5 3 3 8 ii3 Eos iP FH 3f 3 i i: 5 fz 3iss is 5% i ts . 2s ~3 3 EH HT 5 ELH 4 8 EC TT EL TT 5 EC EL TTT RTT CTT ETT a (EE 2 CEE g EEE g ELH TTT LRT RCCCRTR TT g REIT UCT I | ele[1 ele!J 228 || RLE Ee ReCelL | BlLe BE RoR ] ole) : 29 |B(eeimkEakE REEAcR E CE lR e sl a i 1 [FERRE : asks 3a[ | E Eee e lalel l-RES -lB=ole] 3i | gs |[a Eee aE El - -E i s2o 8 || EFTEEE EolRe R=Re=I< c=loER 33 Jb | Ee Re 4 | El A EEEE i: AEI F | ENN- EE-ei -BREEREl- 8 -RR35 BEFl- GEE 23 8 2 [|Elelelel= Ch - ==lleEQ 3 [1| eeoleela ellBelelalallala} 5FZ | EENNl-e- - BEERlSe clEa- E58e-8 -BBeEE 3z [I [[[lelelelel-R- Re laRee lass la) gl & [| le El elal- Re Relle ealeae] % _e8 I [olEl= e | EE ~B=|< a = | | i3 3 i | ol & Company Santzod.Dossntcontain TSCA BI % BL ETT ETTTT ETE ERs EI [RCE g EL ETE ERE & LR TBE RC lta TEs g LL Tl Css g LedTE Cel RCT 2 GL TBETel Cs Cele Ee i tel eT 5 | | E ETLOEaTE E ELem eE e EEe EeHR] 2fo8 || [eBlLT]T[eabllollleellSsels slesmse< EElLsie) ~| EEcHoe [ e[lTET EEE E oR epe = -I | oafe || E ELTLER l =e o a ~lEee ||FBEER|NEI E INER -&-T 2CBl EE ERa -e -R -a BEE-C BEEE 5EI NEENNzEe -5--- - -- BBEEEE-RRBEEEEooo- BE-EB-L 3 [| leRetalalolatelsRl Sia oe lesa) | GENER AES Ee | (=| Ea = = =] = |ld5 II i |(eE ]|[ale ale lERs aeleeolR e EfRe = | IER CEEEe- 0-5-8080 85 | a EeA -EE 3~~ [FEE LL EER Elsie 7 F2al le] L] A A i i, 44 84 i 53 8 3 F- ig: g&3 HRaE iBaglis lsJA 3382 8ir 5si,ts aiEf FiHy Ui g% 8 $5 ss f55i5d5e5 Jiuaius [sSioafoes `Company Santtized. Does not contain TSCA CBI El E IBI TRETTR Z EC Te a TTR 5 EC RTT Ee Telta TT g Ee le ETT RTT i EarTearTT erTTT & RHR a eT eT 2 EEss 2 Sa a] Ts Ts Cele Tess TT i EC alLala Te TT =8 |RC OEEe ee eaeE ee LLET Er | EOTEREL EERE ECE ERE eS | EE ER 25 ie 1(2 |EgEeen RIeEb lleilaRel elolC e cE R ~ EF [ge Ee ER at | Eke ReEEEels 95 | [AREEREel Re- Ol - 5 H3I os 5a B3F 4iHI f5 --3 | ERs El a-RR- Rel CelEgl-| [oT= = Co <P ~ = | == = a Re El leefellasa} [EEE || p EAoReEeEe BeE rn Re l Ee | NFaaEn ERaGReE BelE i el BEE 668 | F HEl RE ==FEE ol| 2 3 : g i 3 5 3ki 3 93 [HN wt i ge 11 8 3 iif it iif # 3 | `Company Sanitized. Does not contain TSCA CB: HL24768:OneGeneration Reproduction Sudy in Rats DuPont 13784 ~ APPENDIX U INDIVIDUAL MATING DATA AND GESTATION LENGTH: P; RATS i | | | || - | | `CompanySanitized. Doesnotcontain TSCA 81 H-24768: OneGeneration Reproduction Study in Rats DuPon13784 ~ INDIVIDUAL MATING DATA AND GESTATION LENGTH: P, RATS EXPLANATORY NOTES Abbreviations = NoPlug/Sperm Observed or No Litter Produced ~ = NoData --_ i | ET | CompanySaniized. Dossnotcontain TSCA CBI Pe __ pailin} sm sm rs DsEma i cm 8s mWhE O1M6S THEETE mTiSl JTE.ISTE STWTSE | | | tremens CompanySanitized. Does notcontain TSCA c= I E-- (i)a -- mes-- cini 1 c ma vrs mi mTeEONGAaSl ECHElT OTeMn JESh SSeE 121 25 + - * sats SGWEE 23 - CompanySanitized. Does notcontain TSCA CBI H24765: OneGeneration Reproduction StuindRatys Dupont13784 --_ 520768 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24760 iJ J-- "INDIVIDUAL MAEING DATA AMD GESTATION LENGTH: PL GENERATION GROUPS: VE-0,-0 DOSE: 10 MG/KG/DAY mANoIuAsLS wANpDOeLA mOBeSEsRVEtD wMNaDeALsYz OBSmEoRoVED PLROIDEUCDED LEGNEGSTTHA(TdIaOyNs) purs ida aa5 :.: :: =-z 1115980 555 ::: :: 5FH : a 51133525 555 ::: ::: az5 1113335550 i5E ::: ::: @@on 11e33d &0a ::: ::: 522 11160001 46a ::: ::: 532 --_ 11166050 &&& :: : :: =2 : 2 11166%s7 %773 :i: ::: @@a | | Ps . . No Litter delivered, however, one live fetus as observed in uterus at necropsy. ee | BompanySanitized. Does notcontain TSCA cri FL24768 OneConraion Reptoducin Siy n Ras RSERODUOTIVE AND FERFLLERY EeFSCTS WITH H-24768 (--] Jres-------- NPIVIDON, NARI DATA AND GRSTATION SANGRY 1 CBAERATION Duron 13784 afcoe wA een meeseemwgliwig mee 4 ummA tomoenl | En Company Santzd. Dossno conan TSCACB: H24768: OneGeneration Reproduction Study i Rats --_ DuPont 13784 ~~ APPENDIX V INDIVIDUAL IMPLANTATION SITE DATA, IMPLANTATION EFFICIENCY, AND CORPOR LUTEA COUNTS: P, RATS | | | |- || 266 EompanySanitized. Donolscontsain TSCA CBI H.24768: OneGeneration Reproduction Study in Rats DuPont-13784 ~ INDIVIDUAL IMPLANTATION SITE DATA, IMPLANTATION EFFICIENCY, AND CORPOR LUTEA COUNTS: Py RATS EXPLANATORY NOTES Note `When the number of pups born was greater than the number of implantation sites found in the. uterus at necropsy, implantation efficiency could not be calculated and the number of implantation sites was excluded from the statistical analysis. Abbreviations -- = NoDaa Pa = --_-- | Company Sanitized. Doesnotcontain TSCA CB H:24768: One-GenerationReproductionStudyinRats DuPont-13784 ~ INDIVIDUAL IMAPNLDANCTOARTPIOORNA SLIUTTEEADACTOAU,NTISM:PLAPN;TARTAITOSN EFFICIENCY, GROUPS: 11-0 DOSE: 0 MG/KG/DAY NAunmibmearl BPourpns ImNpulmabnetratoifon ImEpflfainctiaetnicoyn sites @) CoLrupteoara Count. 97 8 10 80.0 12 98 18 19 54.7 19 99 6 17 54.1 18 100 1 15 $3.3 15 101 12 i 85.7 14 102 15 15 100.0 15 103 3 14 52.9 15 104 15 17 88.2 17 108 1 13 84.6 14 106 16 18 88.9 18 107 ---- -- J -- 108 16 16 100.0 16 109 16 16 100.0 17 110 15 15 100.0 17 m1 ---- --- = --- ~~ 112 18 19 54.7 1 113 16 17 94.1 17 114 17 18 94.4 18 115 13 15 86.7 15 16 1 12 91.7 12 17 12 15 80.0 14 118 13 1s 86.7 15 119 17 18 94.4 18 120 15 16 93.8 7 --~ | -- = | Company Sanitized. Doesnot contain TSCA CBI 'H:24768: One-Generation Reproduction StudyinRats DuPont13784 ~ INDIVIDUAL TMAPNLDANCTOARTPIOORNASLIUTTEEADACTOAU,NTISM:PLAPNyTARTAITOSN EFFICIENCY, GROUPS: Iv-0 DOSE: 1 MG/KG/DAY ANnuimmbaelr BPouprsn ImNpulmabnetratoifon IEmfpfliacntiaetnicoyn sites CoLruptoera Count 121 16 16 100.0 16 122 12 12 100.0 12 123 16 17 94.1 17 124 17 18 94.4 18 125 15 17 88.2 1 126 15 1 88.2 18 127 --- --- -- -- 128 1 15 93.3 16 129 5 10 80.0 13 130 12 13 92.3 1s 131 7 1 63.6 1 132 16 17 94.1 1 133 6 7 85.7 s 134 1 1 100.0 12 135 17 18 94.4 19 -- 136 19 20 95.0 20 137 12 13 92.3 3 138 -- --- fi -- 139 I 17 100.0 1 140 -- -- -- -- 141 10 10 100.0 15 102 1 15 73.3 16 143 18 18 100.0 18 144 1 15 93.3 16 --_ |-- ae CompanySanitized. DoesnotcontTSaCAiCBnI 24768: One-Generaion ReproductionSudyi Rats DuPont 13784 ~ INDIVIDUAL IWANNPDLANCTOARTPIOORNASLIUTTEEADACTOAU,NTISM:PLAPN,TARTAITOSN EFFICIENCY, GROUPS: VI-0 DOSE: 10 MG/KG/DAY ANnuimmbaelr PBourpns ImNpulmabnetratoifon ImEpflfainctiaetnicoyn CoLruptoeraa sites 0) Count 145 -- --- --e --- 146 18 15 94.7 20 147 0 1 --a 4 148 16 18 88.9 18 148 18 18 100.0 18 150 un 1 78.6 15 151 --- --- ---- --- 152 16 17 94.1 17 153 15 17 88.2 1 154 15 15 100.0 15 155 18 18 100.0 18 156 12 1 85.7 1 157 -- --- J -- 158 16 17 94.1 1 159 12 12 100.0 12 ~ 160 16 17 94.1 It) 161 12 1 85.7 14 162 fr 15 93.3 16 163 15 17 88.2 1 164 --- --- --- --- 165 15 16 93.6 16 166 13 14 92.9 15 167 16 17 94.1 16 168 1 1 78.6 1a i | Tm Ee sh a ss sf a | || `inmepclraonpstya;tiotnhuse,tigceisetnactyi.on day was miscalculated. Data were excluded from |- =e`.CompanySanitized.DoesnotcontainTSCA 1 24768:One-Generation Reproduction Study in Rats DuPont13784 ~ INDIVIDUAL DMAPNLDANCTOARTPIOORNA SLIUTTEEADACTOAU,NTTSM:PLAPN;TARTAITOSN EFFICIENCY, GROUPS: VIII-0 DOSE: 25 MG/KG/DAY ANnuimmbaelr PBuoprsn ImNpulmabnetratoifon IEmfpfliacniteantciyon sites ) CoLrupteoara Count. 169 12 24 85.7 14 170 1 14 78.6 1a mn 16 16 100.0 18 172 15 16 93.8 16 173 1 17 100.0 BY 174 16 16 100.0 16 175 16 18 88.9 19 176 15 15 100.0 15 1m 15 16 93.8 16 178 16 16 100.0 16 179 -- -- ho -- 180 15 17 88.2 17 181 16 16 100.0 16 182 16 BY 94.1 20 183 16 16 100.0 16 ~~ 184 --- --- jo --- / 185 16 16 100.0 16 186 13 13 100.0 22 187 18 19 94.7 19 188. 18 18 100.0 18 189 1 16 87.5 16 190 13 16 81.3 16 191 1 15 93.3 15 192 15 16 93.8 18 |- Tae CompanySanitized.Doesnotcontain TSCACBI H24768: OneGeneration Reproduction Sudy i Rats DuPont 13784 APPENDIX W INDIVIDUAL PUP SURVIVAL: F; GENERATION = - Company Saniized. Dassnotcontain TSCA CB: 124768:OneGeneration Reproduction Swdy in Rats Dupont 13784 ~ INDIVIDUAL PUP SURVIVAL: F; GENERATION EXPLANATORY NOTES Note less stated otherwise, a dash ("-") indicates that there was no litter delivered. Abbreviations - = No Data -- `Company Sanitized. Does not contain TSCA CBI LT T T RYNE ... _ es i ss [ini sr ---- vm am P-h pe-- ae `CompanySanitized. Doesnotcontain TSCACBI 24768: OneGenerationReproducdtyiinRoatns |iii 1 J ~~ Luss REPRODUCTIVE AND FERTILITY BEFECES WITH H-24768 INDIVIDUAL PUP SURVIVAL: PIA GENERATION Grove: TI-0 DOSE: 0 MG/KG/DAY wom op wie ops mmo sow Rome wwe 5557 s$: ss: s:: w 2w01 ow u7 F1i2] 1a7 12100035 :55 255 353 102100876 5:: 5:: 5:: i1H m09 oa5: fe52 ASpH --~ m m52 oa5: a5: I5H: 11111s7s :i: 525 3:: 11m F8r 1: fe1: 2i: sS5eE!an niFee RR 12sm 728m =22 Dupont13784 | | EE | Company Sanitized. Does not contain TSCA CBI 524765: OneGeneon Reproduction StinRyats ~~ mae IL RSFRODOCTIVE AND FERUELITY SFFBOTS WITH H-24768 sormpnt (continued) DDVID FUR SURVIVAL: FIA GENERATION Grove: x30 oosm: 0 wKarNY wosen or sms wes maw sow ssoonmse mwa PFL EIE B52 5i: BM o 34 4i: <:i m FB r u a 1: 0<: iiFoor !5 3:? :$: iiil `:: i:: :: - Hiiioos:; ow5 05 ~ niuoso :: 3:: 3;: mnm o o3o ;:: 3:: froHaeyn efFsh ECSerh eTnh i 2% a 2 Dupo 13784 ~ " ET | Company Sanitized.DoesnotcontinTSCACB H24768: One-Generation Reproduction Study in Rats --_ 524768 [= REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24760 sormx (continuod) INDIVIDUAL PUP SURVIVAL: FIA GENERATION GROVE: II-0 DOSE: 0 MG/KG/DAY wamem oF wes ANODE ___GEX RATIO (LES) BORN ALIVE 0-4 DAY ViPmTY 59% 5 00..2785 0.38 110000.0 100 110000.000 10000 h10i0 102 oolme 073 1200000000 10000 1100007000 10000 110030 105 00.1650 0.45 105020.03 10000 1100000000 10000 110076 108 ols:6 10000 0.50 100.0 110000.000 11005 m 00.7630 2 105030.08 - 110000-0000 1nz -- a 00.3580 oles 1100000.00 10000 1100000.00 0000 11716s o01es oa 110000000 10000 1100000000 10000 111105 120 0ola 71 or 1100000000 0070 15006020 10000 Ho55a!n sik 00..51376 0.037 29..046 ola 591.27s oa 2 2 2 DuPont13784 --_ . . | ae | CompanySanitized.Doesnotcontain TSCACBI | 124765: OnCena RaposoSud Ra ~ (a-- ms SO -------- sora pension worvzp me scRvIAL Pa GEERT J nan or acs uns vom mae od oar vmonm Dupe 13784 | | ~ . 2 re CompanySantzed.DossnoconainTSCA CBI 0 Sn EE ---- ~ AN (i. FTrss tbo' J emo ron mn pe two snort ve | | on Company Std.Dossecon TSCAGS! 124768; OneGenertionReproductionStdyinRats (_) ---- Pe. prem RSERODUCTIVE AMD FERTILITY EFFECTS WITH H-24760 INDIVIDUAL FUP SURVIVAL: FIA GENERATION Grove: 1-0 Dos: 1 MG/KG/DAY mmo + ow wom oF Fors saovrte ova m m mo8 u n bi1d 1ii6 o o Eo oB n iii iii io is w3: pra2 Pr`: o ama a5 1125 i15 Bn nH oa n: inw: aif: ~ Fw iT on2 i2: iio 3 ow Py 1% iW wn w ow n! i` 01s W Wooonn Fio HF3 oFiaaSn nTGsae mBoamke wa3ade h at 2 a Duont13784 i|| ~ . | || . 0 Company Sanitized. Doesnotcontain TSCACBI ~ FS ---- [iil] Sosp m (cin-- aan wnt 3i. wmaom na ~ mid ~ `Company Sanitized. Doesnot contain TSCA CBI 52465: OeGraton Reprints nt ~ (om PR emconcra we FILER TESS WITH 24768 oro,seurmeonssortaeo:nsioTuienttCRUTCH avo: 10-0 ums 1 vm son en of rs vrs freee ~ . Company Sanitized. Doesnot contain TSCA CBI H24768: OneGeneration Reproduction Stdy in Rats [i) armor min --_ fen REERODUCTIVE AD FERTILITY BEPECTS WITH H-24766 INDIVIDUAL FUP SURVIVAL: FIA GRNERATION Grove: Tv-0 bos: 1 MG/KG/DAY sma op Fors, ANDBL SEX RATIO (LES) BORN ALIVE 0-4 DAY VIABILITY P1i3Y2 0a2.15E500 111000000.000 221000000.000 1113268 aaae8s 1p10r00e:t8 1550:0830 ii125 aol5e:s 110000:..00 21000:0.00 1fa3 h 00o.6 5l1a 111000000.0000 111000000000 Ei8H o0l6e58% 1110000000000 110S00a00t00 -- be6on aosi: i1000o0000 1502030 1pir3 o0.i5r0 20s0:i.a0 110080%..00 piie 3eHEd 1110000002000 31500050000 sbboden 0GE.i5d5t 90T.134h 98pi.E0e] hb 2 2 a Dupon13784 | me {EompanySanized.DoesnotcontainTSCA CEI ~ re ei re ser ----ci St SHAT e eo m || | `CompanySanitized. Do note conts ain TSCA CBI OR RE _-- ~ IC one ser RS SPSAR OTR nnnrvmonssmcnonsoinsssn JA -------- som snot ne vp -2 : ; | | EE | CompanySanitized. Does notcontain TSCACBI 124768OneGenerion Reprodaston SyinRas --_ po [-- RESROTICTIVE AD FERTILITY BEFECTS WITH H-20768 ara smn NIDIVIDON, FUP SURVIVAL: FIA GBERATION Gaoup: vi-0 Dose: 10 wo/Ka/AY om or ors maw ssw Rgoinm me o H w o w ow:. ow!- BWwooouw%0% ok 8u1 kooun3 mmmooooooEsE 8B ou Bou mBmooooxn B &: fon wwmoomooowE B n ou E fou -- w%oo o8n 1B on Eou hr 30s oB s: Bou: B Ww ook 8 nFEk fyHroSun w1Ea3 aanMwnh oiawehn $F ST Duron 13784 Tomine Tad one Tive faves in uterus at necropsy. | THe | [---- ---- H24768: One-Generaton Reproduction Study in Rats PS s2060 tA REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 sera (continua) INDIVIDUML FUP SURVIVAL: FIA GENERATION Grove: VID DOSE: 10 MO/KG/ORY omen oF Le TRS amou oom: Rsaovme ows w 1165 a.5- :3- :3- 11145980 755 557 s57 1335512 ::: 55: 58: 1113335 1Pya bSs 11008 135509 75: 5;: 3:: ~~ 116166102 75i 575 5` 5 1F266r0 :: 1s: 1:5 112666876 s85 335 s`: eS55aE!n [ t2ahe EEo2uds oaillzeo 111 DuPont 13784 --J . + Animal had one live fetus in uterus a necropsy. wCompany Sanftized.DoesnotcontainTSCACBI $4768:OneGenerationReproduction StudyinRats [i_>) rn cin ~ 424750 REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24760 INDIVIDUAL FUP SURVIVAL: PIA GENERATION Gerovee: VI-0 DOSE: 10 MG/KG/DAY women or FOS PUES mous so msoem oad 1H waon- 3.: pr_: i115% 552 352 32: 11m 353 w7: 1:7 ry:7 111335 13 ::i : ::i : :5i : 1o 3 wou5 a25 ify5 a66 ows5 ft)5s 055 1616665 is: 2i5 2i5 1i6 `: :: :: Ss5iea5n" nh osn ob1asm 1salla;e H 1 1 19 Dupont13784 | = Final had one Live fetus in uterus at necropsy. | ieee | 28: | `Company Sanitized. Doesnotcontain TSCA CBI 124768:OneGenerationReproductionSudyinRats __ -- (d424i76n0 ) orn coins REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 IDIVIDUAL FUP SURVIVAL: FIA GENERATION Grove: Vico DOSE: 10 MG/KG/DAY womeR op ops MDA & SEX RaTio (mies) BORN ALIVE 0-4 DAY VIABILITY 11117a 0.-:3 100-2.0 s-2is 1iB3%Y 5 o00'.ls4a 111000000.000 : 01050000..005 1i55 0o01.l33e38 1110000000.000 12100000077.000 b11e35s8 o015le< 1100>0000 020000700 111365%0 o0ol.l33s%1 111000000.000 2110000000.7000 --~ 6a 16 0o013l3ss% 111000000000 30300000070000 i16as5 0o.l7=e3 110000:.000 1300002.000 65 0o1l5a5 110000000 100000700 55we5Ban 0o0.i.0353607 100aa..l00a0 0a2.s25s 1s 5 29 DuPone13784 | --_~ < Piral had one live fetus in uterus at necropsy. . | Ex | `CEompany Sanitized. Doesnotcontain TSCA CBI H24768: OneGeneration Reproduction StudyinRats - (ipe ern ci REERODCTIVE AND FERTILITY BFPECTS WITH H-24760 INDIVIDUAL PUP SURVIVAL: PLA GENERATION GRour: vI-0 DoS: 10 Me/KG/ORY mn oF waz UES Amo oo somw ante oes pay vimm i1ii15a 100-:.0 200Bo.0 ii1a% 101100%.0:000 iE 200500:..00 : i1i3 1110000::.000 11100000...000 11i5% 1100:0:00 11000:.00 ii1% 1F20r00i0e.0d0 111000000.000 --~ iiia 11100000:000 i : 11f00i00x0: o iii 1i1000000.000 11100000-.7000 i 1%: 00:0 HF8oSaan 10502..05000 525o.50ss 3 Dupont13784 --_ Animal had one Tive fetus in uterus at necropsy . "EompanyShnitized.Dossnotcontain TSC 51 H24768: Ono-Generston Reproduction StudyinRats ~ (u524--760, omen stein REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 INDIVIDUAL PUP SURVEVAL: FIA GENERATION Grove: Vico DosE: 10 MG/KG/DAY men or rmass woes mmow st omy ave 0-a bay vmasmm P1e 100-.0 53_.3 111417s 1100002.700 1020.0 100.0 1153 13 10100200.00 11000>0.00 1113355 111000000.7000 111000000000000 1113336 1100002.000 11000020.00 i113a5% 212000000...000 11100%00000 ~ 111666 1010002..00 110%0:00 16116656 110020000...000 111000000.000 1% 10000 1000 vSe5aE"n 1020.0..00000 5910.3553 i PH 1 Dupo 13784 -- . . hina had one live fetus in uterus at necropsy i {BompanySantized.Hoes ofcontTSaCAiCBnI H24768: One-Generation ReproductionStudyinRats ~~ w20768 [I REPRODUCTIVE AND PERFILITY EFFECTS WITH H-24768 sormDc (continied) INDIVIDUAL FUP SURVIVAL: FIA GENERATION GROUP: VIII-0 DOSE: 25 MG/KG/DAY EER oF F0PS, mmass mw wsoem oar 161790 112 2i 20 mm12 1163 iiss 1fd 7m 1Fi6 176 116 171785 116s 1163 115 1w7m8 i1% 179 2 11< 5] 1e8y0 51 516 1156 118823 180 1i 1166< 116 --_ 11189657 i1s1 5i5%d 1Fe Fe] 1h9i8 11 i1] 1u 19910 iia n1 nnu 192 is is u sesoa.n 1T31s 15i.z0e 1i0l9s S5 E 203 2om 2oa DuPont13754 | . . | | T9- | BompanySanitized. Do note conts ain TSCA CBI HL24768: One-Generation Reproduction Study in Rats ~~ {i5i20l7i68n } NE REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 INDIVIDUAL PUP SURVIVAL: FLA GENERATION GROUP: VIII-D DOSE: 25 MO/KG/DAY NnEER oF ALE FPS aman eso usorme ors 117609 53 ca 5` 77mn 75 5 75 ` ;: c m75 176 15 5 15 5 a5 5 1im78 79 105- 0:5 0?5 313320 77 7 77 7 77 7 1118555 i:5 :i 5 :a 5 ~ 119976 198 05 s 35 s 05 s 129909 191 as s 1 : ns 92 5 5 5 5o%a!n SE i7.h2 od 27.m2 Sw 2 71 ols 5 222 DuPont 13784 | 9- | CompanySanitized. Doesnotcontain TSCA CRY H24768: One-GeneratonReproduction SudyinRats -- n20760 iJ REPRODUCTIVE AND PERTILITY BEFECTS WITH H-24768 [rm -- INDIVIDUAL FUP SURVIVAL: FIA GENERATION GROUP: VITI-0 DOSE: 25 MG/KG/DAY NBER OF FROLE 70PS mmo s sow isovmee ows 11m7609 ous5 157 5; 1 7wooo 7a 5 5 1:5 15s R171i765 7:` 75: ;:` 171173890 -: : s: : :: s 118812 55 wow 155 255 ~ 11189856 z7: 7:a 7:2 w0e7 189 13:3 373 373 11w 9901 w7: 10s5 5:5 HSoaz5!n 2os3os% 72o1as5 12o1mm x 222 Dupont13764 |~ . | | ---------- ere edeee | Company Sanitized.DossnotcontainTSCA CBI 120768. On rionRepost as ~ Rammer: as BRE R760 ( --; somo (esosa Grom: vaca oosn: 2 womne [ep---- si om mao ous son sve oct ony vasa Durones w= Company Sanitized. Domote contsainTSCA CBI irsom gem ys ni ~ rere 8 mS ea (E.) esmmonsrceionn aman JA -- A SNL AICS CompanySaniDtoeisnzotecod nta.inTSCA CF! 16 OmGeren sotynts Pam ~ SeAaTn R ST If Ji in,senrsng.omsiToinnnhcmESES er et vom ---- ee NEE HIE || a Company Sanitized. Does notcontainTSCA CBI 24768: OneGeneration Reproduction Study in Rats --~ DuPont-13784 ~~ APPENDIX X INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F; GENERATION | | || ~ e . | E Company Sanitized. Does not containTSCACBI 1421765: OeeenReprdcionstynhs pire ~ "REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 (--)} iso, SEES cn,smassp: in cmon PADRE wHI IeE evPTeI" n ilsoonee coimoininon FE or ---------- i2 wo roevsmams oAeErE I I eottoso mneimeess aarrees ~~ JE a-- errlcce-- s ope JJEE ---------- ---- J so 5 rie--s--m--r--e JR -------- | st114 0NO memos ABNORMALITIES rere DETECTED JFER -------- FaRt ve emnseres--ses . . J ------ ~~ I 24765 One Genaton Reprodcion uy nRts ~~ REPRODUCTIVE AND FERTILITY EFFECTS WITH H-24768 it rer fr---- JE sm oSml..o.raNO ---- PI -- 00 #0 sews Tere JAR A------ 115 wosevens eres Taree ---------- ---------- 319 we reson rion 190 #0 ssomawETEsS cere --~ B------ NR ---------- 153 wo Ammaress sEmaces MI ------ SN PU JU -- B---------- PR VR I . PR Duron13788 . - es Eompany Sentized.DiesnotcontainTSCA 57 H-24768; One-Generation Reproduction Study in Rats ~~ sss REPRODUCTIVE AND FERFILITY EEFECES WITH H-20768 [--] sermons (continued) INDIVIDUAL LITTER CLINICAL OBSERVATIONS: PIA GENERATION Grove: vio pose: 10 wo/KG/TAY awmooms memComnox mesalyee ossmATIns 146 Yo AENORKALITIES DETECTED 148 NO ABNORMALITIES DETECTED 145 wo AmoRGLITIES DETECTED 150 No AmvORMALITIES DETECTED 152 NO ABvORGLITIES DETECTED 153 wo AmwomaLITIES DETECTED 156 wo AmommLITIES DETECTED 155 NO ABNORMALITIES DETECTED 156 Fo ABNORMALITIES DETECTED ~~ 156 No ABNORGLITIES DETECTED 159 wo AmoRGLITIES DETECTED 160 NO ABNORMALITIES DETECTED 161 NO ABNORMALITIES DETECTED 162 KO ABYORMALITIES DETICTED 163 No ABVORGALITIES DETECTED 165 NO ABNORMALITIES DETECTED 166 NO ABNORMALITIES DETECTED 167 30 AmvoRGLITIES DETECTED 168 30 ABNORGLITIES DETECTED Dupont13784 --_ | - CompanySanitized. DoesnotconTtSaCAiCnBI H-24768: One-Generation Reproduction Study in Rats ~ FE (i) en eroornsm, s(moinnas 2 cn oEs R en --on-- -- a, --" EwOr ms 1F1 G m--r--s--o--es i 74 --m--e--s semen F on rGe-- e e-- en-- ve FeOr vo --sn--e--s--see--rs itte m sems es I FO -- ---- ---- -- F-- G-- ---- NG | te 190 NO ener ABNORMALITIES rrA DETECTED - -- | LITTER SUMGRY: 1 `SUBCUTANEOUS HEMORRHAGE | ||| ~ - | | `CompanySaniDtoeisnz ote condta.in TSCA CBI DuPont-13784 HL24768:OneGeneration Reproduction Studyi Rats DuPont 13784 ~ APPENDIX Y INDIVIDUALPUP WEIGHTS: ; GENERATION | | ~~ || a. CompanySanilized.DoesnotcontainTSCA CBI H-24768: OneGeneration Reproduction Study in Rats ~~ INDIVIDUAL PUP WEIGHTS: F; GENERATION EXPLANATORY NOTES Note Animals with no data either did not mate or no litter was delivered. DuPont13784 --_ --- ae Company Sanitized. Does not contain TSCA CBY H24768:One Genruion Reproduction Study in Rats Dupont 13754 Individual Pup Weights (grams): Fy Generation ~~ ---- Grows 12-0 Lactation bDaasye 0 sa/karday pee pss Tos a s eetPP TSF e TeTET TETn [ f e eerse f ee Tee e as d enTed s sleo[e T ese or T ler[e er rT f1 er aT l] en] bo p Sass esTene es eo srleesrs soe lse a TT1] bo [e eme mae tmeleesrT asT teTTTL TT FT 1 [TesteslsolesleolTTTTTTT 1 hoe lgte Teestoeoe sadesratfeedslT enlariaT tfos ata T ll Lo bo s res eserss e prerteeTe e ra a a ra hoe FI Tee7oah7 mratePeHeaf7 eosftP eereeLfP eotesfI atAes ss 1 --~ bE 0 retere reee ESsy bbf e oo eee ess Toossr rssestTTooe eafeorre resaesefasT t d 1F 1 bo IfTeF essssP ieefP eaTreeareesTeeaTleeT ss FesTo ewsST y bb e E PIee S re etee re s eaeee Sy beP eessssTeete aoesasTaTerasfroa aseTreoao tasToes sa [Tesoe] e e be be I P PeP e pf e e ee e Te rt e eea fed Testees esa ra re a bhee |p EerJeeolszeolT se rT e rT eftrT aoe reT [reTaTT r TT] bone [oe 1seleelealesl[ ea T lT ee1 le1 o1 ] [TeTesTe780796s rs[7a] | [TT11] bfo eg I P Eme P ae e tseesTaeb s a7a sD T raeT Le eeF aT DrieDT ert sefTeeesfaea [ra oo Company Sanitized. Doesnotcontain TSCA CBI 124768: OneGenerationReproducion StuindRatys DuPont 13784 Individual Pup Weights (grams): Py Generation ~ Grow: 1v-0 Lactation DDoasye:0 1 ma/ka/day afnrimealinudp Pup umber FF Jr arr arr sTale srer rTse Ts[wF [uF ln) be e C70 e 0P eee Ee PP NN | Feros oa alsofeos TT] fr E [eR TsR sfH sse tT seT erT ers s e s 1t1 sr s1 l be [oe e Teatee s eleaslT sl eT se a s1 o e+ te] s [I CeTc eaP tePTolCeErc1 P lCPs C1Cs P fA1 sst|| be C p P 2Ce P 0PP e mIe B r s | P ee rr a r t ] lE e [sl7ale oemelmale osloo1l1er| fr CP eTeotsoe leal" r Te TF s bs o Te eteata es esf leala 1 r T maT e a r Fs F 1 pr [H CefsoteolTs F e FF1] ~ |e TeTeatssle esle soe lere lse aleslenl1e|s EE CeItestealTT n F n nF s ] eeleostteeaa{lwmrelfoofloossf To T] ] be [Cp ose slsaeleolsosalee r1e T eT11 b [Ce Tee ilseselr l eesteers ose ere iel r]e|s| [Ce Teatsslesle1 alesT |s T sl pb e Ee A r r ee e t e e ] [TeTealealeolseleerasloelsTlT eo] l pe F er t ] be [oe Tee raatf e eT ol Aeaten1 te1 sl fp o [Te Ts2le saleolee eselseorlesea| rr lssls|sl | k [e Ce a Tslalees nrTaernelTeesr[loeotlreaaallsT elT aels11ol | pe EE E EE E { --_ 306 | `Company Sanitized. Does not contain TSCA CBI H24768:OneGeneration Reproduction Study in Rats Dupont13784 ~ Individual Pup WLeaicgthattsio(ngrbaamys)0: Fy Generation Grow: vI-0 Dose: 10 va/ka/day nRuisahelr SPeuxp p tuber [CTJ e ei eef e zf e r sr ela s oe r lms le e nly ne le nye urlsv )] bo [E elae alsoe lsalseelseslresslsts(esalasle sele ssle salsaarlataelsss]] poe CPeHl rrr E eo Fel7ilesle eeleresleee lerlrotes, bF o [FeTeaTes e alse leadlee eessa loaT lTt eT T atT T sol be F I YC e I estE abes resTy T s 11 | be P Fer F re be e Fe TrioTe e ers esltsls salo ree ll1 al|es bP o FeTre elror lesle eaalle+ar 1 lrola 1 ea1 l bo FeefTesseaeslseo s1elT seerTn ne1t reT ea T n1 t Te1) o1 l ~ fbp eb E [e eTef p leae la sad lsor lsela esie esarld esosle T renTeT ae 1 d 0 0 I ISy br TPEelral SeR sl A 1en+tI IeT r Fts T en F Ce rolr ralessl se rleereeslate a ralserT e T bo DfY erY stY eaedeaedI TY F | bp e e [ed Tsf alerale sap lss alsbalL d sae leC e sl|saaT lpsT ae le|l ol be E [ele rele maloatralyayTF 1111 bF o [seTesleslvslre elvalmol3lroeale 11 | pe [P S sTeA leoleileelesls etlesiealeais|sl|| be PE EY VE R7E g0pesR enI S se | bP e I sPYfPe WY rY pmE e amadeT B sT er| bboe PP[HeeeSTdseaeldseadelE deF iE lsalFeF 1 slE E 1 sa1 sE eT ls1E T o]r [Ce TeisTeolas1l1s1 oo1tTomTl1e1 nt | --~ a Animal had one ive fotus in uterus at necropsy. || Company Sanitize3d.0D.eesnotcontain TSCA CBI H24765: One.GenerationReproducdtyiinoRatns DuPon.13784 ~~ Intvidual Pup WLeaicgthattsion(grDaemys)0: Py Genesation Group: vizz-o Dose: 25 ma/ka/aay aMnatvmear1 ubep p tuber bEo rF F irp se t TTesar m ssa o te r F s rsF[dF se wT s ae lT en s] bbno Fe efeaest er tes nrT eH ae s Eea] be F eF estee re TTeeeaaTTteeeseTTeeaasree te salaTeeT aaalstT aFaeT rs ss T etsT e|a|t bber E E F E r e EaEr s spr oeoeptse esn e eesrTr eeseeTs eaes l be FEeP eTdP e eTberaePClE deeT aat T nP ee1rs TytTP e1 el bber FE E eTr eaf tp eee srbeeuf rtoeetdee e "aremrTsas aTttteT aee rsT s tde1 aer be FE P eee P sa esPef aPtteEaee treCaWirr N a~Tere TreT rr my T a e T1 s ~ |SE eE e nee SS BT Be bnP FF eer o s Ter e eaesrTTeeee enas TeersTrs eeaee eT ot teT ae ]t e T1 s r bo PreNsBP sPedPPPCNECT E PPNP T PC7 || Fe 2esare eatt err islese see r e sti er B err ses 1 tes] | beEEE CP e CP 2e tee s Bs | bbe oe eP CenP E s sEE POa s e EW PCNCaETee EPaTHsomo as Bs | bFo eCesTseafrrreeefr seeaTtsseTeoaTet 1 elreearrT s eerrrT e1 aailaee1 esot[eel s1 n[ae1l1 es] bbooEEdf P e ePrP bet r aes er rr e es e ren| F CF e Tertee sTesTe eeslr a eesTTeerslar eeaste ee rte1 se t1e1 s1] --_ wo | | `Company Sanitizod.DoesnotcontainTSCACE! H:24768: OneGenerationReproduction StudyinRats DuPont13784 ~ Individual Pup Wteaicgthattsio(ngrdaamys)4: Fy Generation Grow: 11-0 Dose: ma/kg/day AMniinrbaelr _pSuepx p tuner F I Jif i slifsTg el [els Ts nlnl+InTs) [o CP eff osha eals [ bea F lT m1 sioae [ F (Cei T fes epfi ie nef5e0a .a6t50l e --61]5e T .6[2i L 5n [0b [1 30o .2. [o 301 7 1s 0.3) fo [CeasreTn5t55aohs.scohea]nelTo0femsoafoaifofale[1 1 | fore [r CeTz as sh f mu oa 1lo s1ml T eo l s aT h h T T eo T a] a l = C Ce ho O st 1R eT i y aTll a1tE 1e es1 ] [CCeeffoeosfmoasrhohe]| 1 TT [ TJ TT TT 1] [[Ceg f esaizlwusha s osh he iee lenons elfeueshll[ seo 1h1 s [[CCee f mo mhaulsehhne T ea hT T o lT onT heeT [ le1 nn 1 o el l boo [ E eop lsumos era e h1 sh s 1 ss bF o [elesTesenter releT sfosl[TT1 ~ fee |Cee melzsss osrualssles eel [[CCee Tf odriii ssz toaliooi sh]os e )osoa soosh af]i| oes][ ch1 es fo [CeTsM selo s b oo lcohooh[o iT oo sohT sei [TT o oaoliT a ie olih T ola1 e sT d s bn e [efsafTeT sr F fT os l Te Ts1) bH e err e r eeee er rr F[Ce eTsd losTe orTe [reeseT frofoa T [1 be [F Ce safa irseo sbee seoa ell LseoHdoa zDlass sl f| oon |s ) bs |[CeeTessluosasTuoaolluasoeos leol e 1 TTs Ts T beF[Cfe m feedl L ush[z1a T T hh T ne ] 1l bo [f CeT mse lus l he T n s rT aha sT omes le ha1s a1l bP e [f Cefsf TeeE hushe iehb anreee lsT ea ] sT if1a bo [ee lenfm auafllsasfli eu.soessol e[a1e aTe_aTfe in1e, bf e [Ce h e er fn eT r ra eF sf F i ou Trs T ee aT h a T o 1 s "s 1 -- [Ce leafsifmIo1al7o TsTf1 o1 al | Te | `EompanySaritizod.Doesnotcontain TSCA C-1 Individual Pup Weights (ozens): Py Generation ~~ Lactation Day 4 -- J -- cope 0-0 e saver 3 mT afkaTrdnyy Twa TE ~~ I CP EPG FG CPE TPE NT By i T3112T3Ta7] [Taz] [ema malsmelel[aelnel | 1 TT pe PERRI [eme eel s 1 i Ts T pe Pepeshestoeis hee HH Ne MOYVYMYNYVMYNYNMYNYMYNYNMSVSM-- [oe TeaTs3Ts |e To T a T lT so Tl 1 [Ce Araliaelse aializa[al isa0n .7 3[i 1 os be heaterpee k [er malea ate ss ana e elals 1 | [Te TsiTveslie7iealios| 1 1TTT [--eTosT Hoi a i[a Hot s i1 ea1 lo 1 s be ERs Ee Ee 1 weed ee ce TT rTTTT |g 1isalissall iaa s(ta oaa[ li | se T li T z pe EHSHERE ee e mivleelaslaealias| 11111" pe PEHRRRepee |g ialass elias(iz.a(aieliz.0 ais | 1T1 po EHR Espenus har mealsTeslsalas 11111" Femas TT 1111 aes es sansies 1 11 be HE eehos oor -------- hss esses TTTTTTT 1 Fe sass 1 1111 TT1 T 1 Ie sae essa -- 11T--1T"1 pe PeprthebedetedS 1 es Tio2T30.21s.0TH0.219.3 [10.0[16.2 70.5 5.8[9.3[t0.a| | "oe Tselss se odes TTT "T] [--eTioolai0 ss10.298[T0150[Fo.5fi02 [|| ET har mers nT aaeRes Te TmisTyee s sr T eT sT T a --i T-- oTl 1 eeedee eT 39 TeTeiTess eier[ose[oa 1 T ] [To 19517 880 933 s29 ss 1 o1 [ 8 15| ebbLL errr rT har [Cems eems memes 11111] [Ce Tmoelmor misarganal[1111 I [Ce mosmosans 1 TT 111111 has [--Tio.eTioelv.30830.810.0183[an3]Tos [1 [eo TssTo7Tso 8s 83 v0sros esl | 1 JazearelaisT aii a a aa a ia 1 01 az] . be EHR pepe pea 1 | ~~ --_-- | Company Santzed.DossnotconTtSaCAiCBnI H24768: OneGenerationReproductionStudy inRats DuPont13784 Individual Pup Weights (grams): Fy Generation ~~ Grow: vI-0 Lactation`DDoasye: 4 10 ma/ikg/dny afnirmaeudp Fup msbor [oCe TE TaF leF salF s eF llF es mum nurs) be F CeE rTETTr [elet sTt es[etsselHassaleiee oln ralToelreallseas]sa|| CaefT ossa maresT [T T] T bP o ef fivp e ab fro.etae f aahsr oshee ioial do boaadb1] o ) bo Ip C EP Er PC PEEPe EC EYd EE PENFa EV t FT e| IC 7)SO| pber P CE e r mma H r os [fe5i7o5.5[a7sfranoa.l.ef[eeieotrziooesallrrrafooeaT ioT T sl] T sa oe FmPEdEFaChPEoElYdFPsShosNmaEnsma | bs F PE P0r 5 PC CY ee Be s | I Cl 5 PE EPC Ee YPeCYCt PE FC n PCH ntet | bb F [CefA tocofr1os1f1 ioca1 ioal [CCs0osfsfaaoslaal TTT| bo IeC pCPCeFEdEPuOEFaC hFYeEFEsFhWeL WEt75eT EVdH EhT assal| hoo [P Cefre iaSrht ooda1aT ia eaT fl aT fi s ] ed bP o IC EPC FPEENFPE EF EEIEC PEL EP T Cs P i | TCsefTrooaamsmasssleaallessalT TT T T T ] he [pCe eazoaafrrtsfie siisdol orT em EE TTTT1 be F IC EPA C EOEFOE FFU ENFSP EPHFPFP | be CpeeTlIEmare asf1e1 aeree 1 ee C epreshf aises de1f ma1s1a 1fT oT so Tr1d ] || bo IFCeEeP)l7ib3aB a immer s| Tesla ofa olsolssleslTTT PP CPeT FnFa EFr EFsN fT H aTeTo1a 1 f 1Tm1a| | -~ = Pinal had ons 1ive fetus in uterus at necropsy. i | IBompany Saniized.DoesnotcontainTSCA BAY 124768:OneGeneration Reproduction Study Rats Dupont13784 --_ Individual PupWeTiagckhattsion(gDraamys)4: Fy Generation row: vizz-o Dose: 25 ma/ko/day aJnuismbaelr uSepx pup wmber I E [FSm0slm0a 0 mal 01e0 Ee1SnC+ 0aIVlBe1E s CCee [f issi Tastsse e1sl o1uilT aatT os 1 l te[E s Jio-elao.ofse o]ss[soo] |l Ts T da [CsTErP EoP.FmU)oEP.EsPfH oPENsIEhPAoIET PEsNElT EtIEPsT ENEtET aMinT el| fs [o[ eTs.e [0.- 00.s7[e a5.n6e[srf oosalitoa 0sa]ls3o [T oen 1 T fi To| rn [[ oe TFssplsT.TafRoe.saslsesulsopalosslhseas losslo1 s sle) al fs J[CaoTfiorsls.-d s2sf[soae[f0i.o. aa]5]01 0.31T9.1 1[2500T[sT .oa]7 | 70] .5 PR I[ePTNEsPaFClFsCPS.YFIoElCPSeYoFLasACtIlCP1 CsNIEaEIleT sfT es| fore [jCeTaeos.lavfesa laostrlos.allss" eal fa1 aill T e os.tT eiloT sssl FPS IF0CPE3FECCPPSJEFCUEEIE PFIEPC FECECRTENC]PNPE EC EEN Ms | er [r CeTs.ofior alsasTsT lr aT afT osTl A bE e Ce r m r m r PPR [CoTs5ToiPsE TFEosEsaW]F0.Y61F9E.0EEnCoCcTalscel11 be [C CoTe sielp oloi lsisi osdi osd[a edefe ot stn or l ia 1 m fe ["e oT306p 15.5[e 6.0o]5a .d4[so.f 6]T sas[o T ssfsT s osfmaal lTe T 1 T s PY [CTS oeTs:5Ts.5 ses.6[soa]95[S 5I0[IrI oelaT oe[soT s o1 a[5a1 | bes [C{eTm i0:2a [10.l 0010m 0 30o.6.a2sfall aceafm asscai fl[ ieosT tla T slT 1 i] o | bhe or[o[ elC zs e zfiii loltn eiioa a lesf lli s aai s1lea lsmp eoT ssz al[1 ee ]alrmn r1 se]a s1 l1 f ls1i ee1 ] o sl| foe Co oTeala raloses arT leTsT rT e aT T leTn1 s 1 le1 1 sl [ToT [0.0 s.0 ss]0.1[5s[roe se[0.5[ee 7 00]509] pe I [Ee P FFY. EERs sslT arer li mal1 r rr a 1 rfro 1 rs ] -- bor [Ff CP Pi HFEsEFCl Pstm aI lz l1 olW 1 is n] eh [[op CseTr iesa sTarasfinna seflaosaJtl a1sie1 o T sh1 o T s] | IFC]PPEFE FCP ECA FE FCPSECCIFEU NI I | | -_-- se CompanySanitized.DoesnotcontainTSCA CBI HL24768: One.GenerationReproduStcudtyiinoRants `TRADE SECRET Study Title H-24768: One-Generation Reproduction Study in Rats Volume 2 of 2 Laboratory Project ID: DuPont-13784 DuPont.13784 Aurnors: Eve Mylchreest, Ph.D. Joseph M. Lewis, B.A. STUDY COMPLETED ON: October 19, 2004 PERFORMING LABORATORIES: E.L du Pont de Nemours and Company PH.a0s.keBlolxTM5L0aboratory for Health and Environmental Sciences Newark, Delaware 19714-0050 USA. ELL du Pont de Nemours and Company Regional Analytical Services (RAS) `DuPont Chemical Solutions Enterprise: Jackson Laboratory Route 130 Chambers Works . Deepwater, New Jersey 08023 USA. . Worx Request Nove:] SERVICE CODE NUMBER: J | | Ia | | -- | Page305 of 524 Bompany Sanitized. Dossnot contain TscA car H-24758;: One-Generation Reproduction Sty in Rats --~ DuPont 13784 _ APPENDIX Z INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS Py ADULTS || | | | - sw Company Sanitized. Doesnotcontain TSCA ARI |Lo 3 3 i i ig g 3k 2g3i 3 fF 1 mamansessssnssasuaness ] e Hd AdAdSNdANsReRR2R3A8Sk8 ;$ g5. : gd f ~omweeremzaunssnsaasaasy | sermon ~3 z ! g f g ii . ii ; 3k ii 82 ER ES BE Nan Tn deR ooe nTNm EMn OT. poS| 8 . 8 S8RRARANNINRSRASIISILESS | BompanySanitized.DossnotcontainTSCA cBY Toe i | i 3 if . id : giic isi J I I Tunsmvinevuiann 3 & Su i eevee acsadaqehaaages | | [CompanySanitized.DoesnotcontainTSCACBI .2 z z g g i83 . i i i 3 suddediddddsdnddssandaisd B 57 gy ooemgasasiongigeecesacen 3 k : BR 35232303203%3RR00EIE0NE 8 5 31 eeneceezssesssssasavazes `CompanySanlized.DossnotcontainTSCA CB .2 :2 d g 2 : g, 3Hid i 31 i=: | ig, F fra ARIE I I Log Hy i maann gIIs ISRAo REARn RANY `Company Sanitized.Doesnotcontain TSCACBI "og 2 | | a g i R 55 id Ea 1: 2 8 i:2 5 FB | : : EE GERBARAARRRERRASITITSSSS i BrveySeitot martes "RY .g i : i : g . y2: & 3d 3 8 3 3 i|Log| | k tg <3 Es og znessaiessigaiesizasages g a J mrmmeanamannamanmannnnnns ige&. . 38f sausaassszassoezessessan BpmpanySaniized.DossnotcontainTSCA CBI . :: : g i gi 2 3 853 1EE1. i= EY op azsasqnennosnnacennannn | 8 2 H aedmMmanmenYmsnnnendacng { g | ret ~ 8a 3 { i PRRREECSRUSISERRNRANALR "og 5 | Li3g giBE 8w 3k a. g{ =i 3 i g 4 dgoagsdsdgssnadsdrasdadgdedrdsazssdsdrdaidaadnns STU nnn df L 3 : i AR RRR RaARRAanan { BompanySanitized.Dos otcontain scacar 2 i ` i i i gg FR] if ic1 ? ie 5 Udiddndaddansdinddndndn 1.3 be gl 4 BY RRARIGOAEARRINERRINNIREZ IR g 3 ; 1] SEN3AIRNNARARRRIRAAIINSS | BompanySanMized.Does notcontain TSCAcB "oy i LE g gy 82 ; ii i 1Fdi E i 2 is ARBRALRARARRARSRARRANESR Bompany sanitized.Dees notcontainTSCAca "og z |: : g 23 fy iz . | Hi if i1 >i pi FREE ESRESENeLsEEREiEiEEsEEEcPaEENEEnLeEaEEEnRg 3. gaNnIsiaNaiissInasiia | 8 = a8 ARARRRIRRRRS88338358358808 : * i g g2 : L qd if BE. "CompanySantized. Does notcontatnTarn mor i Cs CI d: fy 1 | i : ) 2 ==sgzugzsunuasnnaInsnaas | `CompanySaniizee.DossnotcontainTSA car - 3 3 g 2 i iz 2 5. ii iFi f | EE 18: i j ie C2 Cr, | | i 2 Hd Lg g% HB | | dedvevmememvevmememmnes "Company Saniized. Doss notcontainv0ct | | Og i ! |: fyge . i2 y 2: FE ii | EE 9 M AeaevnendesevIieedInveen FH g { i i 28 seveoanNnEARLARTTITLELE i pe g ~ BE RRIIRABARAAAAAZTILZLIRIE CompanySantizsd. Doss notcorteTac cay ~ og f | g | Lg r 3: = 5i 58E8%2 3 2: 3% : . oapmasgsssnsnantanne |# i5 3 : 88 EERRRAARRRRZISR3335332as 5 ikB " 5 | "CompanySanitized. Hoes Hotcontain TEARFRY Ton LO cot HE noa I. $4758: OneGeneration Reproduction Study in Rats Dupont-13784 y APPENDIX AA INDIVIDUAL ANIMAL PATHOLOGY DATA P; ADULTS | | | - { -- | CompanySantized:DoesnoteniainTSCA CBI | "or | i 8 8 Boat fi a EE 50s i Erie go t i 88 Honig[AHa]& i: aha BE Blea a Fa on oil gdPoa8 BEE Bd y Riis gIiHg: db EE gmi ppahl BHiEo: 3 : TPOoEE d mEE EH MoaHIL i \ ; 1: =BalLGiaugiinhnh flril| HI | a 31L: ogdiH engoedT mBialln gdirriiitl Big mBBEogooo I Cfof ggeoleohiT amolH epBB ooE om,iL mcdniE pE iiminahg ErmanSunsostcn rsa t ! pd 3 io Pon g B 1 sPo ob pf tt i8s h5d iy bl | foe Hol , Hyiid lal gies ong Chi Toy, 3 Phin BEE os: BEEN | . gf gig |84 irr Effarllidiin CompanySaniiized.Does notcontain TSCA BI ~ oi i cop jit I % 3i E;I | Tis i 1 3 g =" 8 2 g f or i I] hh |Co 8 EyBg =a fei 1 4 | ifs EEE iE g1!i: iFgop ; jiPgg Bs faren b2d8 Palit oee |~ :3 i PsFd Lielehibnd "Company Saniized.Does hot containTeanat ~ : ] go . 3co if of bit PL a I ! E iy |id MEE BE fli i foii1f IC.d SfiFhETEnEE [8 2 gd 3 be | reer - bo 1d po gs : { fs gog 3 g $d 8 g i: :i Feil 8 Biifl HH | I goE s R1E 8 i2 I~ 3 | | : iin EE Fae iv CompanySalzs.Doss notcontain SCA CBI | 4] 3 : i EOE | TRL LeH if, EI i i i HE 8 i| tg: fi | iE : ir Hin | i 8 fi e i `Company Sanitized.Does ld 3 gg - I : Po g i | 3:i { tI y if bi i | gi 3 |i Lo gl Lpadtd id i Il vo Hl iy HEL J ie EIH NEET i i Efi og 3 Flying L|o || PaHiEiliini, EE Fred `T#mpany Sanhized.Docs no containTSCAcB ol i: PiEf l Lo SEL LE pp i $i pila fig hh Ld i 38 He 8 llts:& S | 4 E ; i Pita1n: Blyersastattwins | |7 i pd 1; iiroid TL 3 8 | . fp atl MERI | fo hi EL EgIrinEdE :, El L an lii 8 3 Cb pl 3 cPh2a rRaEEr Bd od qlEt ~ PE Pree bd CompanySanflzed.DossnotcantareTens any ; pi oPol Ci i3 H if E RH Ch Hi ghd 1 iy 3giFI 3 f ae jiil g RIEL : Po, rit Cd CpfgHleit iae od: BIdii 58 CompanySanitized.Dossnotcontain i : :| ; Pl i3 H il E | P; o 11 1: Ed INEHy AH EE gil hl ? LE0gre ' i El] Lil ily | dh ii of li:ng boii C l- B| H EHi Hnd CompanySanitized.Doesnot | [FN i 3sPoioHIr l pH sf 1 gq antl A a ES 8 g Eo. 52 8 ; 4 3ic cohgei n 1F1a , ey lidi : biill |! i8B5oaEl888iE ou. Pa ! {Sompany Saniized.DossnotcontainTer cat |I~4 Cd 3 ! ! i by o pl n | i SEE| pd ty ii Loeg HSE l JIi HHiH | | i 7: Hl sid ` | pg Hind fyiiii NB SLUM | i : TI i JH z g H:EL `EompanySenltized. Doss SE Pon I yo H Hg 8 I] sf itd T R I [| gb Pe ii Fe on ; pi iE g iE yic H piRlFE Lr EEN] 1 EEE 3 o F222 33 Cd 2 BGE lHEigiEire tr adit EompanySanitized.DoesnotcontainTSCAC81 | Coli BE EEE | : io : o3b of>edH for hh iiill Hgiee | 3 LL HH CEI 2 HE ELE fd Ld1 :Lyfi HBEEid5 Cd Co Hi AEE EA CompanySaniizet.DoesnatcontainT8a cpr | I I : :ofPoaEF yo Bip Pop 2 8 Pisa | i i FH EiEfEs s 3F fo g ii: a pild 3 EE : hRn IN For kL ~ 8 reed 1 CompanySanlized.Does hol containTSCA CBI ! p| i FE og pop:Po iro it | it, ad ~ itd pad ; E itIr SiTgR]E ' i: oI giF2 i: iig in8 nn Sindhi .J SEE ATH EbRe 8 FBE Eiiihee CompanySanitized. Doss netcontain TSCACBI x i :i i PE og : i f: do itn ih I~ fe LIE RE iT MER iy rgd FI hyo :1 1, Hiiun lire as LCga dr intl 3 CompanySaniized,Doesnotcontain TscAcar g i . } i : FI iq 1 iE 3 gE a 2 ER n 8 TL TRE | i;l i M EE E i. pf Tolardo i: id gz giir. hh rel fd sp 52 1 ie: bt gad EE i : ili 5 go 2 Bil 5 EEE EEEH BfggEIEF | ` Bremen Doh8 i: iiTl i Cbd EH | HT; RE I HIRi ii 13 L| r hgi pge | I: E: ig yi 12 3 : fig fF NH cli Lfdi ipl aLdihl CompanySanitized.Doesnotcontal a od 11| RN ] go 8 f x I i !> I Co td f i IH iiF: HEHi Po AI | yr of |: CH bei BEEd oo | fei ov YE | _ notcontain TSCA. Tot 3 Eo | pg gEeId :: i by if zMpBdE ; retbooofod ir g ic polo i g iid ial gf iid caf i {od Ls 3 jEEE 23 Boaaal it fern i sie PE fared `Company Sanitized.Does notcontain TSCA | id thi 3 g p H i; :Podibd e 4 fiAl irPol sbigit: Loo E HH d i: 8 go, | HH EPEiLEdTI 328] 8 CofE FEE us 4 3d emersonne. :I a. i i` ff ioil i poa l : {bai g 5Eyic 2 gh EEirdg 2f%d [iii t fos EBE zs Hii ~ 3 PE free id | `CompanySanitized.Dosenotcontain TSCACB; | PPoo | : 15 i if ? z i;[I ok frill S Ei E 1 pr adill ` EL 5 FE] ) Pjog 1 daEEE [ERLE] pin ~ PP treed Cot i : i id i 5 8 i |i gg by 1d Eo | LH ir2 og ntl pg fd :. Pte gi El) Hfdn 8s BE reli : Thi Ld7] ad llhl i - 3 FE Lees il | | CompanySanitized.Doesnotcontain TSCAcs | 3 3 1 3 : THEr tg l Is i4 I Hrd 8 8 1 lfr g8d ER if Cote i 3 sag if !: gi Bi Poli : Egiola Cr ~3 { 8 85, EF EP learil `EompanySantized. DoesnotcontainTSCACBI | Pol ~Codg 1did i ipopdod 2: fred | td gil LE Bg Ey ; i. 4 1i: 7i IEEE Es3i8g Ffoi ih Cah Ld oH g |3 EEE 2 FEE AErt ee 3 ge EEEEEEE Ef Pere dd EompanySanit.Doesnot contain rsa cr | i 7 pd Ho | i Ilge CCllaelegbo Ji EE ig ip ? ig gii.os 1! iid T1E: gl ji; I Eiiidis Lg|{ 9 | ir Hind Sie d d Sg gg5 EiimpanySenitized.DossnotcontainTSCA 5 |E 2 i Pond 3 i | Pol : 2# gE L 5& i Poy El 8 BE og HE ipl i0idzi ERE i8 tli $d pel | i EiEtr5 E idE e i HEL 3 0i1.x dBiLygdLli 1 Eo oa I ci fii | & Ef fgg BE {I : qld 5s I ~ f 3 Pp2 ifiiiidngith || Eoosn tcrns EGA ot oi Pi onif Ph : i fr 4 ros LE Poe Hh sly y E3P i! g : : ge php Bs iy FEE 01 HHH l| EEdE jL EiiId Rd | EompanySeniized.Does notcontainrsacar | 7g i Ft ` : fil PoE IE Phy 4: P EEid [- Eola ain ; HE !Po Po. BE IELHoft boii Lg EE dedi } CompanySanitized. Does notcontainTSC: rg | ; k i poh E| I1 N HE L; ; 1: 13: ||]i g pe: dl fs $88 is i lp h HdH H | ~ { JHHpii in ! Bompany Sanitized,Does | | of id .i z g gi 8: Ei i - fyi BE. 58 % . iis HH $58 3 31 dig id 1% : g8 i i go BEEg8 EBFE PERE as AEEo f L H <n 0g L5P3HaH | CompanySanitized. DoesnotcontainTSCACBI 23 : i : : Ld i 3 { & ~3 i . 3 iioc3 ii ipdd oor so:ii iiiirtsd i a f i# ligE i oi HE 8 8 , iE asi) 3 zg 8 Ey 28 Pa El 8 EN3 HERE Po,BEER BE EoTfogEg E3E8Y Rin 22 Sez TF i a fF tere dd EompanySuntizedDossnot conteTschcat | Poi ! i : ; i:PolFiro H Cl 8 Pio dE Po hr Pe jaf fs g |.1I; i8i3l ii 8 yg o BEER EE LCo r i His la ~ Pp leet BompanySanitized.DossnotcontainTSCA cist Ty yd | id | 3 i2 i' 1 8 I Ht bo EEz 8 ig 3 dH Ha gE og HEHE g2%if gsgf 1}3 %| |Lgi:Te igrdl EEE IF Codd t s Cei Llenii de Corps pests i Pol cb: Gd ip 4 i iltei fi ili giig gHiil ThggEeEE En 3 p hih el EE bin Cd jin Cd ihn 2 8 HE Pr" I ; po ob : i x8 : il ogre ony iy td (HE iy i] fie cif fi ' 1 HR | i i ih 2 3 EE i hii `Company Sanitized.Doesnotcontain TSCA CAI od i: Poi i gg ii :g (RP fs i g FR p:i3l fg Bt pr 3 4 FE BEE gg 588 4 ; MIE } i 1g; BE : hfai a i 88 |3 RIE | EompanySanfizec. DoesnotcantataTera m, Clds P . E2 A I rg pI bi PR , HITRE p8, b5d gif ppl Ring : i gi gy s> 8% 1 2 . HHY bof2 i PosBEsEs zsF ! Lg f1EE Ed | Sees sont | oa i 3 Poa d:ol fhrai fg i) 1 i8 fy od SE EERE Ee i8 :} ptr 1] ho lh 3 uw 5 58 Pe dg | ipl i 8 iz tani | TEE ERLE oe Cb, ~ 5 A | Eompany Santized. Does notcontTSaCAiCBnI i1 Dol : : ,] ig + i1d |; ii 5 Bgl, Hit ili Ci s hl :i: ELliie]f eisf | i gid gt |i1 i: i sB Ehief E d io1l I : IN | jEEn ae d| ir Bh Fold SE | EompanySanfized.Doesnot, i Tot Cd | nd | HER i HH | 8 | : of fil ~ GEE aad : LIE5 : | cE G Eo ii iy if Es id BE 8 is EEE ' i Iahie HE 8; Py. trgt H 8 la 1bo b hhigt [|I | 1Coy& TE LH eile s 8gE SBEEERE[RDF8 8,5 EF 3g Jilalh 18 Bree bd [EompanySanitized.DossnotcontainTSCACRY s5 | [I i il 3 i i if 1 HHE E j gf hHY hifi: il iH y fi] RE Hod | iPleiiiigs |I If < NBI E R E I wi | TH hn | | | oo `Bompany Sanhized. An Pol 3Poy8 i i i od g rg ig id HH st HIE] : PpiEhe8 gi ;5Fd f8 ' g fi1: Tileji edot iF jubgd PERE ae | `CompanySanitzed.DossnotcontainTSCA CB |7 0 Bh Poh og by il hd iy ii :8 : go 8 LE if 1d A i; | Bild : ir dn , fig 1% |2 1 h ggldi 3 :gop BEEiR iLE i Pliny Lg33 ipfliinp iI081EE E3 ET1 `CompanySanitized.DocsnotcontainTSCACBI - Cy A | i 7 ei | ih Ly ali : co dd | fi: i 8 ly IRE | Pn |i, iu boing Nn alll i SEE PEER Ch |~~ 3: fFIp liinth i |i ne ; ] i & pCo od foBl ielnl Li] Hy HH i yg ; i 1 Si iahl | oo : HH |j Erin ay hn -| Pr Leer dif ompanySantzed. Dossnotont Ny i TI oll 5. OF 2polo1 gd Pol iid SoiE gi Peds 2FA8% s1388182g Cd shih gi: pil 1 | Jiig! ; Foi ig a. ! F TIENEIL gEy ~ od PE free bd `CompanySanitized.Does notcontain TSCA Cif boTot Cy pot Pol i 58g HE popod iidi ih, i fifi go1: iil gn HR i : gg 1 |i NIBN ie Lo] jn Celina Ld dil | 2 Ef Bree id | | BpanySantized.Doss not containToca oot lL | . oa :o0 d1 ; YEp Of i elf i Poi | Pig fiyt, F 1gi,p i0d1 fg E r I1le 1} : io EEL BE : yy Hi EO fog EE 33 :Pog i BEEH iE IF haraes |Pod fiingrei ~8 bedded ! [EompanySanitized,Doesnotcontain TSCAGRY Cd oq i 8 Coleyi | SgIs[I Pe 8 iip Hot Eat8iNEgE HRT g gs 7 g J be di 2 i, 5i 1:f 13 i: 1 alibi { FE a opEEE zg8 E S.50 8 g . $3 Eiid% BB EIEEEE (EompanySanitzed. DoosnotcontainscacB) Tt |3 z Chipeo id 5 i if i: 1 fi of ii poo55hg i iy I hihi 2 fg 1d od 8, id iPfve5 de .5f 8% Cog g5 oa: giFEEipiEE jo qn z 1 ogiit bl Cbg 5 NqEoBE liiggggNffft | | sd FiI liN ges - 3 Ep leet Eompany Sanltized.DoesnotcontainTSa rg |"og3f i iPo | ph | Foor i; iHE5 g {i ifgliai i: ili if _ i TREN ibgE E wno yi Eg 8 $80 Ge Eg g&a# d E8 goj ib: i iugidlt Ppfie gs 2 , 88 FEiBgi Lod |g ~~ 3 Seidl ee g 5. 1iifsi Ey PE Free id | p: Bompany Sanitized.Doesnot contain Tens amr o| f3 : g j i i 825 io8 ! <i # 8 oe hE 3: iEl { Pop CerP. oflo fo hp at gab i gh i31d 88 83 fei bd 2 5 iE ; 88 5; iiytt L PoEliEs Cl hb 1 1FH [ HEH E Z1| : al8 ii Pf4 g PlEi olaab ogtgia1 LLoEd irEE iddaitiid `CompanySanitized. DoesnotcontainTSCAcB ry | TohI} if a li || i a11d : # = ii! Po i a PEEL ; dia Pll jg BE op: Sidi Cd BL iih CF } `Company Sanitized.DoesnotcontainTSC/ Po 1d ro Ld ph : ;1 3 iF 8 Pol Rl do2 i bye fp 8d p L--- n 5g 5 Preo hd P4 e3 f: aiz PgEEE rs LCgl dhehh | ` mersot to icin5 | Hoele Jb2 He FR HA rho Clogro8 |5 i or i1 ff # H yY e deed Lisil ce ail yy S CLER HH i 2 + I8 i $38, 99 ; ---- -, | i : iPooiro: i ios i gh fisb,f p nDdHt Ppo pi 0 t5eg n84 ; 4 fy ig 3 FP o,zEg 58 1Ci sdr82 bEn REDnDO CompanySantzsd.Dossnotconta TSCKET ~ og Z| . . 2 2 ; Bid io t Po op jit | gih ,| fdyii il alll : ih HH iy is IE TH 3 i 11g fi g po, rift 8 PopEEE re 5 a [irr ig Ld gorebl i2 HEL 2 ! `EompanySanilized.DoesnotcontainT&eA ~~ cLhoidl o A 1E E[iEL iPE , iIHiEEEdE E E 1 pz r lfLi5ii2 ta]tEB :. E Hiiy r fsils:id01 dPo1r: H pig lil CL Pire |C]d eigik ii BompanySanitized.DossnotcontainTSCA cAI 3 i8 3Po is p i3io Hi} ig 11 i, Bl Ihi igilt p diay5o|qn ] hi i io,fgtiiikti gs | cp HH - 34 Pr85 Lil: Eompanysanitized. Does notcontain ~ : ;bo1 d po i i: 8 .8 i gH i1 Hji : i, frie pl ri : i FE shout Bi ERE rh 3 FI ;g ig i: [i g go i 181 [BF oIgEBE zs i cp ili | BompanySeize Does notcontin 5c ome / | ol ? :Pogii 3 LE | 2 TRE A HE Eg Solber54 gE ` por alli d iy1 2i g Tliggid i: BE EEE 23 CLof& ip lini Le EZ BE... IF greets m------ 3 Pog ; hd i if Pol & 3 gg tH Po 0 3Pg li 5 oo | Cd oopPiittil1 Et 4 pp liiR]p CompanySantzed.Doesnot containTc om 3 { po pH : A fil i . ii, di fo oa gg EP i fy EI i|o 31 d lfgdti i I PERE 2s Bompany Saniized.Does notcontain TSCAcr = 23 . io i 2 3 gE 8 i] Pol os Pd itd ty if gr | Hl I: Hh - gg d2 11 1118 :3 itir: dsi8F]6 iy HERI 55 IRE 3i Tig o id 13 dil | Ig s BEE iit 83 8d | |l &a ~i 3cffqri ofEseSge SsEedPvlpeFs. FE Ladi { BompenySaniizod.Doss otcontainTsca cay , : | [I i3i FE i 1 ff oiF bgiz fl EA EIR 8 gf ii Eg sd . ALE J be If 3 be EN Lib 1g! HY 1 Lgl Pit gz lo sd Fis : Pp HiR EspnSstomc - Co 3 |Po Po | hHal IH Po hHoil i, ij Lo3 | | pity HIT i8 | lth CompanySanilized.Bosiriof containTSCACBI I 3 LE. i iE Po EI : 0 & by fd ph ai : i SIRE : i Pilly Jiy hoagn01 iPj ol; isite hlo Ch 2 gee 2 i{ `Company SaniDoetsniotzconataidnTS.C; mC o hai | Ez ii 3 | i 3: g1 B i iPol: i: if 41 I Hi l Eg fr fs :1 [i or alin Chain dirSE lLir ly |i OTE | ~~ | . . : ip f Pooh Pod fie: SF1 i1E H If.. ~ gtd i EEbogyy Bel pl i. 15 H88 g25 iil TE oy EEE sd 1108 flaraee 1 cpE bid fags 83 Ld3 Pi F fE rei | ECompanySanitized, Do note conts ain TRA Aer -| i . i pd I i HH i Pn rg I byoad iy if Hobo g . g 8k | if Za 8 BE HX gagg io iElEi: cf [iii] Lf { 8: 3 jalithin d & oPE oorgge EF free dd ZompanySanitized.Doesnotcontain TSCAC81 : ip A. od I g ep y ob fg C1F oTfRE By iiif jo HE Pi i 2 i 8% & 8 `EompanySanitized.Doesnotcontain TSCA CBI | "oe sd sh | iifo515b= FELHy fgof dpos re4t d 1 Heil ]1 oeFbgloiring | Ra Ld De lh | 3 i g HH PEF orerid 1 i 2 g i i SEH 1? : 5 8 fg if 8g pai 0. 3 8 i * ilpi ft 3LI s Pefos iaid d 3 =gop tPrEiELbS fgoeee ogg SF oggg 4| | i bhi CompanySanttized. Doesnot containTSCAcor i 3 i: i :3 ;f id if 3 ie of ged gifg fe gfit iEL8 fi osiEg g EE . TE igo g8g2 08 ER : i,Eo JHE i;] L3I g E8r8Esg ESg Hi BEE : EEE 5 ga o8az Cd fn | ~3 Egoego Preirlezibdh | CompanySanitized. DossnotcontainTSCA AY  i Pl : i: LoPoa i fe : Fo id i | gi 2 Pi HH | frill nn fifi EH i 1 Hig 1 FEbERiIiEs : = Ela ~Lg | iiysForel ] CompanySanitized.Does notcontainTSra. a: Ld | i pd Looso ii ytoy sfpbbif iLE8 id it 3IdEEE4 MffgId R58 3 A bs 1 3 EE 3 2 8 28 gE Cb | 1 i |4 : IBoEgNIEETER2E: s BEF BE i $d Ir | | [Bompany Sanitized. Does notcontainTSCACBI | i of gHo rt fri iF i i. jeg 5RE aw fpiie as Helis | : 21 ii ~ 3 PELE | [Epeny Sanftizeid.DoesnotcontainTSCACB L, i bo i sd $ 8 poPood i i zg 7 8 id eo hd x 8 i8 ll i fz 11 ico: ERE F on dnt ii 3 f 'E y30 iii gt fIZBRFiHE: il]f : ; il 1 fF faaiss : Bf oggy 88 i s fh oEEEEE &Ids| d C4 ei 8 lSo.il BeE | Eompany Sanitized.Doesnotcontain TSCA CBI - | dp i Po Pi oodof i iF 5 Cb:: hif! d { gi: i 1 Pilg El ph HH boiid gs uIEEHE ah | {EompanySanitized. Does notcontain TSCAcat | EL LL Poll Joopl p i i zig, i HHig MH fis5 PoTlLy [5DE8RsI (6 gditail Lf ip Ep db f si 7 FEET Lod Ta Lass . BE EERE: BB `Eompany Sanitized. Doesnotcontain TSCACB! m1 5 iiii z ir if, gi pr ig 8 iy Plya Pod 1 i; T e d HEI jp Ed gigs ifs ey s BE Iii di E henl i PE giiota Cl Chinn i i RIE | EE i BE H8 E 11 ! Eompany Sanfized.Does notcontain T8CACBI - } : i :i PL i iE a jo i 2 8 i ge BH ig 8 8 Eo ] : gi Berl fi 0s 548 {1 FIL Hib 88 8 fg id Ld sii ; i 53 i1 F LgUilE ilL eiis 2 BE gs fEE 5s -3 58 free bd CompanySanhized. DossnotcontainTSCACit iHE Pod i go :| iili: | go: fil L|Co oEPE 2or EagI i8g iE aibll : 32g3s8 SoEfE g8E ' Cl 1 go 131 if 4 3 Ee I| 3 Pog! HiiHi | Pogiig zs LLogd 1 { jipiiliidinen EompenySanfized.DoesnotcontainTSCA CBI g BN f i 5| | 2Po boi i Ho 1 || Iid 1 i CE dn ji ild TE 1 Play g bp g CSfE Hilt gi oo | Hh ; | i | i Sanitized.Doesnotconttain TSCA CBI ~ } Pol : 3 Po 8 p3o i8b8e pioioih syPooanby if | g 8 fF Eg Lo: gil ig i 8 8 L 4 2 EHH it, e iiy L 0 12 f3ig gli1ei8dgga:Bodsi EH o5, bgE tiE ihR iE gy4 :5 + $f FoErlECTiE Ld3 Bo4e B 8 EE EE od PE Cree id "EamoanySanitized.DoesnotcontalnTERA At oi I : PE ii Gcobpai ifgp I iii LTHoE Hn ; I 5 iy iy 1 gf541TE HiI i d Hpl s : HTN] f Cs inn CH } [BompenySanizod:Dossno(tcontainTSCACBI 3 1 iN :ii)5i1b3d Fin HE Rl Ljei aHii l |i: HiiEl | gy 3 5 ! i Ho ETRY gg Ei i TIN] |1 iii bod Lo i Eegg 58 |aE RiEbHeeEs 06 LI EspnSwit bce containTSCACBI rg i 3 FR a Ei EHR | if, rid hiFg 0s Ea fy i | 4 iy Io: 1 b Eo Pt Rh I Li g ile gir ee { {EompanySanftzed.DossnotcontainTscA car ~; . 2 t :Poh g 10 iiy ! aL Pi - gc ;1 H i E 4 P21ig01 i HEiE i 1g | Pig PD Hillis | H H E ; oo Eompany'Sanitized.DoesnotcontaiirnTSCA C81 LT gi "ot ; i i. :8 | ;i C : H i of ji Hi EfpE 1 Ey if li ; 2: ::i i Ha H |4 - | Lilt TOBE BEEE wow Pe oriit fgils `CompanySanitized.DoosnotcontainTSCA CBI Hi i83 i i ) |] 3 ; Sid i iP i 2 iy i H) n ] A li | )} at ~f| Hl - : i | Pod "oe i j ;1 ; TE 3 Po. 3 iB g C CoE E HHo fo 588 58 i, irq iE ii F3 di iipi 2| f Po. b BEE nid CE1E hn ~ 3 LF reer dd | Company Sanitized. Do note conts ainTSCA CBI ~ Cd3 ` | . . if ! ;| 1 ir! 3rifiB f2 i iy 5 2[I 8 gwn id ii io fr 1d 84 BS oo: L5 g8 . on i 2800 A Hte i3 jit 5s Til iy gLps 2 g sig Bf io jig i Pog BREE 41 :i : EpgoErEiEn1gs I Co . s BhE oErEiRE i CC 9 SO 8E8sEs F2 HHg ii ConyStet. ose THEA Pol BE: ii z i `i iE7 onBEi Col Popo Eo Py dd zg i BE Ex 1 i, 1; 1! 1i : Eyiiifind{y1 Cor ly { iF ogoEE ge ~EEE dd { "Company Sanlized.Doos notcontainTSCACBI Po 1 1 hg : fa i || tz jo hi | i: 1 F te28 8 :. loli,d 1 died | 11 il 1 : RH ii C| bi Es 2B pREE dp edit { CompanySanittzed.Doesnotcontain TSCA Aa | ot . i ip 1! Poi : Lo ef | 4 i fp ed yo 8 i: eg Hd ie i = fg 3 . 3 EEE 8 HH Ey digf oi po Hh 3 [I [HE Pi BEDoe CH Lf pp Ell t EompanySanitized.Dossnol conten TSCACBI |l 33: 1;: i} i od 8 8 Pon 4 5% a PoI HE { H io Y i2 g zk 1 2g 8 1 EE = jg oit: ashpgaEe sori : fgiiiis CL dilly L 1 REHL | . CompanySaniize.Dossnotconta ras on. - | | :: }Co ipo 5 |3 so {g i2 ii ff g8 a ho'! i pg Bt i f: y 3 8d ih } g p f it s ai5H8ili i i || Lg 1i p gHhH : EEE : Bai "shiiig dl Ti HFI EE 4 LF tees || BN - Eompany Sanitized. Dossnotcontain bo hy |Z ii Po] 3i3 ii8Lo: t :7 a fe . i EbLiol pE0d 0 og8 gbiygas i". PE i;Eg # i8 ; litt ` iE. rody E, RE 3g i: ff gidf Ig Tree8 HE iii EERE vor HH i boas LE ] fyiigis i c 88 085 Ff 8 Biigi EE4Ea & 2 8 ggg EE Ll Hl 83 P8E8T] FgErEeEerEEEbGdE Lompany sanitized, Do note conts ain Tscacsi ~~ 2 iNn | | Poa CLE | IE | p i qeo] fi og: ag igif E! a j i{; i8: | cy I $1: 3 T HH IE L fe dHin fi Pbo of .mnHn i Ld pp |CC 3 CompanySanitized.Dossnotcontain | R 1f | i iE ` boi if % 1 FEL y ge fg L i l1 || i HI g H 1 eeh d EBRRENE fi 5 : |CC ih iinin EE be _ CompanySanitzsd. Boos notcontain Ld :| 1gi | Pod z 8 g;B 8 1 g iii fped 5 Lz Ei d i: hel ifp1u 1ogF : Bia it i fgg PE SETEE EH | EdmpenySantized.Dossnotcontain TscAcar "os | | i1 i i i joid] | 2 | tl if hiLil Hil | i it; PE ibis | ii i HBi8i i f - El | i | |S Ha h SS Doesnotcor 2 ii i3 piodr Boa i gf sit I is Hi Hi gad oo Solfaeori Hia sd e8 :. byog dmgif ge L1obohom : i: b O ifEfEf Cd ~ | sh EF mth Oat EompanySanitized. Doss notcontainTSCA GRY |, 5 Ld . [I heh p Eo H ProgPohg 5it; 1 1hoH pf ail ; 8 EEE ! 11 $1 na 3 2 pi g 5 3 3 iE 5... CHE $ | 3& 2 BBFf 88 g ER . BEuw EEa beEaEdE il `ompany Sanitized. Dossnotcontain TSCAcat . i i mw 2 ; |i i : in || fy | i i | | Ll i i FHRg y | I i 21, Hi i e ih HH Ii || L emer | L| , . 3 fy i iE a : iff i ig 8 z pid Pod fy il fi 8 ER i Th gfoEi EaE st)8 .i 2g 2 gif 2; FT hh bi Pte ii IEg I$of:1gt i Pin 3 2 EESFe 7E8E 8 Ll tah P| d# P Si ol riih [EompanySanttized.DoesnotcontainTscA car LL ji Sr yh i gi :op pd CEH ibe ltd iE.E idiadiEl4 2 s5d 5: ir 15 ii iso dt 1i1;alfi |1 L ola eai te {3 sd . ! CompanySenitized.DoesnotcontainTSCAcay o 5is5, 8 oITRE fel fr lg i1 fg: BE : fliaig | si ia | ------ | : : ip io TRY 2 ug Bh toHpo | Co: k if cfadiifg:g FE :: ' ; 'BEE" zBgE i | i : FREE Su linn PE fpr: | _ CC "CompanySaniiized, Does notcontain . ; i ii 1 i 8 Pod rg 0 gd 5ig;z | 8 PPo ot iy gr : gE ERE 1 0 : s 19 : Fd i 0 Lied gd 33 iy | 5 sad 3 gs & Ha S55 8d HH 3 ie EYPi1ea1 | Lod |2 - ab 28 BE oEELl EE Lele Coo d,0, E EE 3g. diBeplls EE free dd Saniiod. DossnotcontainTc coy i . {| Ph qe ie Hi iPoida i Ii zg FE i8 iE 1; f fil ff ig fprod Bil5lg 28 8 Lad 5% : 5 I 1H8gEEet g HE1 riijd 11 eid i Pgiie ae NEJ sg HH8 c EE 55 | CompanySanitized.Does notcontainTSCA CBI - : LiE Po Ch 3 &5 io gg EE APR 1, fg tf HY LH 8g 3 s 58 2g g Byi 00 Tiaiflei HE hin ||g EHEEE ee El R Ed RE Pd | i il i Po:3 por S5c 008 Li oo if | itd fgai8i% Jiig fbh fr r a high d Fog EL g: BE ! lin 7Fo ahs BiEE!3 Cd EH ~ 3 PE frre bd | CompanySanitized.Doesnotcontain Tsea = , 3 id 3. 3g 27 3 HE s Pol ri i 5pi ii Ef g 8 fgtd [ iRiiA Lr hh 2 E & . Ph g 31 aIPEiRong : {gBEE 2s 1g ili 8g 5: ! `ompanySanized.Doesnot contain TSCA Cx: | = gd Point ' iff Po rg PE frad bh Ee 8 , Pr 588: gi lo: 1 gEF Pooeii8b8 bl 1: fF R FiI ts | Sho o 8 FEEE3 E S| i8 a 5 5 | no ~ | oPl on ipoalr 2y Pg 0d frog i, ig ELIE i ylgE RE E% N LEEg E8 F[EII si1e8s 5i; $b fd i EE Caran dE iiih 3 PE deed! | Company Sanitized. Does notcontain TSCAcat | I | i7 H1 d1 | i EE Lig L 2g E i 52 3 dhe ih EI be 1d :Flyshiitngdd CL | ee ] 1i gc 1 a) 1i0hyi H HHiiHdl iTig H HIn RE 3 iPp Hi | z i 88 zg i Li Fn 5 PESlHeeIid B | Company Sanitized,Doesnotcontain TSCAcal | -Co i Lo BR | HE 2 1 nDoLbi ERtEH | i Plog {3 588 58 F He n Hn : ffir gs RELI : : see bi `Company Sanitized.Doesnotcontain' - Yolo i ai ; | i 1k | rt ped | 5pro 1 ite iHEiiHilE Phis jd gin yl Shi osd Ci PC Egg 3 ca thEL id ~ i LPF feerid | EompanySanitized. Does notcontain Tse ARI foal L Crphfii| i; i iE Gs 8 gif i SEE hi gi] P g 1: a hp z 8 : : Po, iit Plil as o Hoag EE ~ E Pp iH iiili | Eompany Sanitized.DossnotcontainTSCACBI - Cy i fo i i: Lo | 8 . i| i De Hl dHlh i 8 i FE !po Po, bh i Pi |i D Bnihh e : fl | h ay 2s CompanySanitized.DossnotcontainTSCACBI . i bob HE | ; . in BifEoobmo Eri ii. bciefl] ; gla CE| inh HI (i : s BEE 13 | Ci HH Lg Pla _ - "CompanySanfized.Dossnotcontaln T { oi ;. | : z ie5o | lint , i i: i: j1 Hot i ii ii Hill Pi E : 2 Ela i & Ei g BEE 23 iL Li FE i || a | BN not containTSC/ Toi Ld - lit al I FOEiL : lo gfgT dH ifopd TE PEi: 1hp yif ii :SHLEH PCF gEifag |~8Pood2lefilegnzhg gitf EompanySanitized.Dossnotcontain TSCACBI A y f B: nie 3 H : i Ho 23 i5 i1 bH i : ol | l | Pe dl fl . BOE i gFhi i : : Bgl ` irl ~ | oh Company. 1. Doesnotcont rf id | i: in a iff nob: rg [HI iy id FH di i so 1ifig 00 ; 2 SC| yf4 dPC de bing comimep--g--r--a--n "ot id i ;i Pon , 1 tha i1 gf 0 | cc by gt Hop ig & gf 5 . it gel Por508 fai EEE geeg Bg CH od PE lead lt "CompanySanftized.Doesnotcontain TSCA CBI - 4 3o 3 ii I Poh 3 Fl] (ji i 5 oh | lal I TI |i i BRL pi Es HE Isc8 CrP|oi ha | : Ppt C | F `CompanySanitized. DoesnotcontainTSCACBI | Im op iby Eon 8 i Poi g Ea EE Ho A. Hi fe: E Bi fol | bn SEF g8 d fr1% Piigjlbi 3 Fi 11g ii i Pog HE Bop BE zs Cd TH | 4 pa pd % 8: | CompDrsanyT56sR oh Tf i 3 25 | (Po HA | i Pp | Pipl I ft hd | 5I g iidg EEyEiEd h giflie Pryor dgibna Chitin 5 RILERE LLo yE i EiC8r8EelBEniEEntgks | `CompanySanitized.Doesnotcontain TSCA CBi Tot id in | pot! 3So iE fg; 1 iii Be Hil gloEo; g# i. EirL, EEi ih h o g J n hl EE TTR NE Hi | "CompanySanltized.Dossnotcontainvers ami lL m {0 # 2k{B I. i g B 5 fg 1d ot 3 : bg id i is a] ig , pr gg | peli CI EILE 3 gj; bi jEET 2 Ld dni Erevan Si CiFoh aHrE d Pog TE A HE HiE Lp58i0 td Bi 1 Peiggllfeate | LP freed :: i Py HH iif |:: ipo,FyHCihiiififn! Cd |4 |~ g fgg FE 2 fF Bie ng :'FIERE E (CompanySanhized.Doesnotcontain i| E iponEpl i 1 if Go ji fp SR Po {fg 2g 8 1 1 Hal gif Li |] Eo, ii fH | |i g EfTiIi Lg Hild | PE Lead | Company SanDlosisnoztcaontdain .TS Foon To 3 A] 3 1 io 3 iB 8 Ho gg 01 TRE Big gd BEER] Big 10 food Lid Ed . 3; 1d fies 14 Ey Z 5 . pg 8% Lp iy hn 3 Py Hh Sow 8g o i fg EEE Cg | 3 HE i Bd Spon | CompanySanitized. Does notcontain Tsca cs) : Po Bp ful po sc 8 Eid Pos is : Po il EI BitE i ty bPprdd 1g id | flea Lgo g qH rHolioipnheiifstfn | sevmmstmarran ;i {Pooilo d Cole g :] iGHyeH8sF | ib: : H ii ol | je 1H | i | 4 1; po i fii Hil] Lg |ne Le lee _ CompanySanitized.Does not. r 8 gs i | 3 iif || ii iis f8 : il 1 fy 28 fp ed Pog LI g: 1; FHnr ii1d8fose8t: . gid gsi #1 % be, Lit roy 1gf i: 2 sig Ee ji Bi SE wag 1 F Faiaas 2 BE fgg 3 |i Tf 8954 EE |Lg& icfa olrigighiosi:n rt PP Leer bd CompanySanitized.DoesnotcontainTse or. Sobol : 3 Po 3 i : A rg PEE Co gg SI TE ] iff bsnl by if gE Poy g 1: Hii CL hn 31 felTEi 1 LPaglhinlos L| d# r3 eSigLidpid | `CompanySanitized.Does notcontainTSCACBI | Pogl HEi [I i ; gf 8 z Pe EE id tl thy ad it i: i EI FH jo irl fsiegd oEfk ii; Hf FH : eo rhil i gi s BsEa BREAEECR4C4 Lo : 8g 23 PE Ladi "CompanySanitized.Doosnotcontain TSCA CRI EEEERE ii EkLob: i111 Leh fy i 31 iil LEE ES Pi it ibo iH ii ef : ] i, iil n Cl epfgielegnahs L . B13 55 ~ | Pf [hn CompanySanitized. Doesnot. lp dq $3 Eq I BBoEofRiLetf BLog BE bgigifgd L| ol i iif gi ipe or adil 3c fF Baio g HEEyT Hi dgj z Bie ogsa; lg FEET BETHEL ENE RL gp lil gEEE 1: Ld AEE Soro ashsmc" : :! i P| : Br : Po Fr g: p ] o4 I1: gh 3 g hl 5 gf y 1 hie f Hi 1 gi030 RB SH Le hdl mp Suites Sessmotconee 2 i 3 i Jg I io polii 2Po iidos fFIeos HE LRL E ' 2 E be Efl B1rHoly b Hiid] i Hrpgd EEE | ; |} .Phi iHniil rEHI i 1 do || _ " | ! a he CompanySanltized.Does notcontainTSC/ g .i oo Pool E : i il: og i 8 3 fp 0d _ i8 si fic i]t gi ae pon gig hiei ] Po r giitfs ~ 4{Ld: Lg irl g HH olt Hl hii | CompanySanitized.DoesnotcontainTSCA CRY - i Pod Po g sop fil ig li ii I Ht I ig & os 558 58 . FR Gil PolFya pilf 58 0, Til Lgi : FiloPpifee Cl RL BFF did ER -| 34 E2Ed Wilhin Fadil | CompanySanitized.Doss notcontain Tscacay 3 iioifr ProPood nt fT fi J sf EB L EH i1 * PPEiLest ! oh clingogREl ldgs Ly th { CompanySanltized.Doesnotcontain Tsca ory bord Po3 2 iF gE 8 8 gE Pod : i 4 hBk L: 4e i 1i1fiiff fgodo tiiff i|ai iby iii gFE iBy: |r lfiHgioHati eli L| og ~|g { Lf5 e4 liei PEHIEdEReEeREd CompanySanitized.Doesnotcontain TSCAC81 ~ id 2 as : fl : i Hod IIH i id I j HE : i: iif In ' di Pel H Bon ia oid ; |-! |i | | | | CompanySanitized. Does notcontainTSCA ct ~~ | 5 :; i : ogi Pol Pr o g tiy l if 1 Pe ii li $88 Fg : iii 00 H;Py H pPehzyH 0sd I IH : ; i 8 gd : TRIE Fal L iy PEE ; -- rf Co ! Lid ipooio ! NER Po ros pid 4 i FE pif nt} ; 3i b olLii i fgEEE 2 i : 88 5888, | sii ---- bpo or :3 1i: f1 PoyP8 oggiiggtd fl fgg TRI] b5 e hl E2f gk pEoERl aHhH iIg ElHiEnEgD EE -i HI TF tree bi Company Sanitized.Doesnotcontain TSCArar "og . od Poa | dip ~ lard gi i ol Ho Pil g ro:8 ip;:2 8 8 8TRE ph:e LE Ha BS i [gd 1 |3 |1 |1 Fl Pep 1d 1 gi; bf tH iid is L Logd ~ HBoirlile: e PE Ladi CompanySanitized.Doesnotcontainrsa mer HI rif pori iBytotf gp 0 + gbiid if gid : Po 1d BL g i: z 1 g hg ih 1] 1 sig Bs jiigifli Feie id Pd siaittnih - || jf i | Hy fPr5 e ii |iE hHil Hi i bgHl if iih FH iA | : Pri _ ~~ CCLg i : Po 3 of iil | i51d poy id gs;: {z af 38 fig lEE iid i; i TEETH] iphF sH88E5s aLro fiit Cb 1 I i i, i118 C| l2 eqp lfEEeGieid B ~ 8 A PE liar id || `CompanySanitized.Does notcontainTSCACB "og 3 2 ) i yh i 7 oI Po ipl FE il Cl SE ail i fio cag Bf : LEH Br lrg if gi i if i ; i PgginEiE in33 |Lo i I CH Cp illiid RN 5g | `BompanySanitized.DossnotcontainTSCAcay | ~ 1 Hf icifiE og Ch poy htt | i: i ge ro hi Sy ii if id qboa FA Silat E3EbL qe i : HEIN Pogiii a `CompanySanftized.Dogs not cantainTSCA ARI - rad A HT IREPople td pe an 2g sil 5 Hn i fig ik EI n SI TH fogoee ge Cy LH ~| 84 HrErC bEREadEdE | CompanySanitized.DoesnotcontainTso ar : i Fl Pol : bpd Ghai] I i1 : |iFE HiEy 1 4: ji Li if i STINE LHSHI i s BE pEiE | | Company Sanitzed.Does notcontainTSCA BY To od | iPo LI Pod Hn | gy pid 1;Ig& 1 ERE NE HN bir ipod giEbfYe Hi Hi il 5i fg; B1 IF pit EIR 2 g& 8 Ig I~ 3 fo8 53 PE Laid CompanySantized.Dossnotcontain soa can | | CoE . ji &8 7 Ep 1Poor8 : Bp gy frat ipSo o0 yaldd HN id ~ | gc8 EN 25 t Po is 588 5s Ply be: BE oPolry digln 3bof iioi s igz Co ] | ~i : BE BEDE ss BoaiiE es cH hy FF Bere BE CompanySantzed. Does not conti75. ory "3 5 :i i i Chg do Bp RIH Hi E i I ito i writ bel |] $1, i 5 i ! hy gd EE ii bo i Sf ip ln BompanySanitized.Dossnot cont [Co ad] 5; i LHI lof || 3iffy Po iBs:i r::g dg B12Pyy51gi fB Pe gil Hd : i iile | gii: EiEhEn C1 dn go: P i hgilina Lf Rh ~f LE read id . `CompanySanitized. Doesnot cantatn Ter I ; Pol IH C1 z i Poy qt pon ; I. Hi 10 i . phn iT,hy j EI f 3 5 gfe Pliilfl 1H28H4 28 ii ggfogk fiElEeEe L 3: HPpiliial Company Sanitized. DoesnotcontainTSCA 68} Cd2 |"1 aE i 2i : id . i i | ii | i Bln | iFto , iHEi : | i1 :| Hi |fri,g P lso ] : TsHilbRiEit: HLiHii dHHi gEES L| g FEF lees _ | | Sill -- stoma i Po ~ 32 iFo di yi! { if JE HY H1 [iEIl] ;. i EE g P diyrodlnn b: oi.bi i in ziofeBEO pEEiEnCeo L| d tr Enid ss-- ~ o 1. 1d i Pol : if AE TIi = HE5 Sg ge i PE 24 8 $88 5g dy hil 58 EEE 3 z ig 25 Hi x n 3 fog Git EE 3 fg BEE 1: L| d3 | i8F R3 ap3 `Company Sanhized.Doesnot containTSCA68) ~ Ii; | i 1 iig |B i Pood Po Hy Bo I! id i FHei | igcd lL ill i i fs: | | -~ ol byl Baill TH FE oss ML - | oH scam - gd ON i ito gr 01 hGiis f Ly oali iy3 frfgl ]!i iiglgjh :iBeE s BEE 83 C1 Hi | &} Ld PgfE tesgE gsPF PF teerid 1 "CompanySanitized.Doesnot contalnTSCA CRI Pog NEE piel fee Hi : fi, pd g Php | |r | ail | : ||| `Company Sanitized.DoesnotcontalnTSCA CBI "x wr odd i gofod8 Pod gE TRE JLoIbLo b HyEa 1 E 58 dtr ined 3 3: 3 TF Pill gig iE 1 fF; 381 zs E08 gE Lg dr Bh | {3 Shen cp iid : 8 fF 2 . | |-- 3 id $ a 82:[I iLEoe d5b0 i PhFyE] :11yjg tedt f ii FPoHrth He lrglbig piHiEiRiId Pel: 4 Cb ipl oop iil id 3 i P8 g Br Eg E uoen | a8 13 Eo Of Og EERE 4. 4 gD gr: 0 ~ % Pp raid A Sperm | | 1 ! ol: : i E: i3 o i alj. i| ir HTH iEpLo.d 8 . 3 Bi1} i e ddBsi;filg ny leg11 : C1IN. i g BBoEw oEw 53 Tei NO HH `CompanySanitized.Doss notcontain TSCACRI : 1 3 iE 8 i 2 Ef EI rf ef yy oo Hi iff iii ETE 8 . AREER be ih 1 3 Sig Es ;PoLrI efgl; iBE : Egitigs CLygH ir lip LE88 sll 8ggy EE DampanySzolizad.Dossnotcontain TSCACBI To| i i - a 8 Codd || ; ! ifypo1dd dot HE 8 ~ lard ii 08 ia BL 1 i: rei Egai 8do S88 5 nh hi J]oa pPt iliing 8 | g2 Sh E Bii 8 gg BEHEE fg fgg, EE ~ 8 FE Lied | i: CompanySanitized.DoasnotcanalsTSAA 01 | [2 .i Poi i 1 i 2 LI i i i58 f gE 8 HfEi 1d 8i ME iff FE sifid pseidi ii:f : :, PE d ficEbd ii | of Cr3i ig ~3 or ibn bE 5, rib il EINE pfq E2R8E8 3Co4 22 Sezg FF Hoiiidgre iF feee Bd Company Sanitized. Doesrot contatn Tena mer. | "oy j; i e i : 8og .i : Pod 1 ilo fiai hd ~ | fH is EE Bed :. iE gi gt BEE ys 3 "ii. gig fo gg El E88 22 | pesto ometsomscRer: i:{ : 8 3 :E ro | H1HEN | ii iil : lh ili ;1 i!: | i ys il ibi Boot $80 4 SASH ; ff TRE 1 Bia | I OH LL | i `a Pod 3pooFR r8 i fr il NE id ETH Ly de ibid (RN 1 IF b ; oo. a Hifliid ~4 { ili `CompanySanitized.DoesnotcontainTSCA CRI Poy 1 ., . pod 3 Poi 0 tor ha if Pa i i 34 1p 0 g Le ht TRE Hy sian Lote 3 i; hei jg BE: i: CpF riag df | Folin LI d8 aFwaHdEo E SCEdDEREs He E CompanySanftized.Doss notcontain TSCACB | ~ ois } I i Po :i fSE d 2Po $e Epa ER i708 8 , dii EL 4 1yf EEE pt Lind Plhiled :[EEE biEiiElg]g } RIE iCo od faed rnil ~ 3 PP tree dd Tog og yoi ;i 7I Ho Po Coyle Be oe I se hat Eify 5d En Bg 08 EI fr, lini y1j 1t;i iHiEL i : pli il ETH | | "oy Sd LH i8 iPa f o LE Hd | Py hid | PE id z HE CoE hoo S| ola7gd& o ig 8 PE8 Boy asl CEE EB BE 83 58 g fe: 1g gf fg 2 = HE iin NSETRE |4 SE biddise "3 Eryosemtes | PoCol & 8i 3 gE 1 2 gf Por td THRE] i {fi fe Eid ; gi: (hid 11 i : fig 18 Lo]bo:th sHlEiINdE C~ e4 iSfHLE inLe | `Company Sanitized. Doesnot contain TSCA CRI -~ 3 C| r $ ad8 & | yp Bid if i Poy itd I sZPi 8g , 8 E iE ai br ili | if Bef id # he gf) iy ab 3 LdE ~3 | : fF og Pp gEEE That LE faedid `CompanySanitized.DoesnotcontainTSCA Ae bo 3 g fg 08 LELo 8 8% gE gd 1 iE id fi, 4 1. HTH 1100s DP hig 3 : i g s 81 FEE | 1g H iEE rl5 CompanySanitizad.Goes notcontain TSCA CBI