Document GmENkQGOKN05r600j9dpyLxjx
------
merottice correspondence SO
interoffice o~espondence
Subject:
~ubject :
DDIR~AAFFTT MMNEEEEEETTRIIINNNGGG wMMiIItNNUhUTTEERSSic.-- HODGE
MEETING WITH H.C. HODGE
EN CONFIDERTA/al BML
aApprriill 2266,, 11997799
TTHHOOSSEE PPRREESSEENNTT::
M1F..lT7o... FF.DC.
CCGHGaarorssidieefgffefii--tt-hh221u1.88----22o23f2200--c22aE8lifornia
L3HLJRi...o5CCCDh!..... HKLKNLoraraedoZozlgggeesehhrroctnee--- -U2-2-.22232212-o3368f666s3S--eE11California
RJRiRR...IIhAAEAE....L NOOPPPebbereleenonsrrddkoeeonrrp--ggrr-22=aa11ss8322ss--132286----328222200--22E8
ER.IAA. POrboekdop -2202-3768-2B
F.A. Ubel - 220-2E
Those present TShaonseFrparnecsiesncto
met on April 12, 1979 at the Hilton mCeatlifonornAiparilto12r,evi1e97w9 raetcentthe rHeislutlotsn
Hotel wHhoitcehl
in ianre
SraenlevFarnatncitsocotheCalFilfuoorrnoicahentiocarlesvieiwn Brleocoedntprreosgurlatmsawnhdictho are
drieslceuvsasnt ftuoturtehe plans. Fluorochemicals in Blood program and to
discuss future plans.
RR..AA.. PPrrookkoopp bbeeggaann PC-307 is used in
the meeting cthoembmieneattiinogn
by giving background on FC-807. bwyithgivainhgydbraocckagrrboounndsiozningFC-a8g0e7n.t
FottoCfo-8ggi0iit7vsvee ipsooriiillunsceiaadnpnddleivnwaauttsceeeorrsmbirrineseappteeasillollneeannncwcyiyitnhttdooiarppehaacpyptederrrfoocaaoanndrddbaoppdnaadppietesriribvbzoeoia,anrrgdda..nadgenOOatnnee
oppIfetettiiiitttssiioomnnparnwiwuanafsscaicptgglurreraaennttdueeseddbsyiinnirseattachhseetinallngaatteepinedr11if99r66l0e0u''cosstroofffoocorortdaniitaetsdssduiluutssfieeovneyaa,ssl
asnudch.a sfulcuho.ride
WwIiittthhis eomttahhnyylulfaaacmmtiinuneer..ed ethylene carbonate
bSSfyuuobblsrsleeeoaqqwcuueteedinnnttbgyrrpeeseaaerccqfttuliieuoononntriooaofoflctrttahehneeaecstssuiuulollfnffooonnwnyaialmtmhiiddfeelPuOwwoCiir1tti3hhd/eHy0
eaatnndhylaaemmnmmeoonniicaaarbggoiivnveaeteFFCC--f88o00l77l..owe((dSSeebeeyaattstteaaqcuchehenetddiaffllloowwrssehhaeeceotttisso)]n
wiItth isPOCsIo3l/dH20 It is sold
as a 35-40% solution in isopropyl alcohol.
as a 35-40% solution in isopropyl alcohol.
Fo..rAng..aniUUcbbeellflrrueeovvriiineeewweeddlervreeelccsee,nntthuddmeeavvneelloohppemmaeelnnttthss aininnd
the areas of ethpeidaermeiaoslogofy
serum saserutmhey
organic fluorine levels, human health and epidemiology as they
he serun organic fluorine level of the individual who was rreellaattee ttoo tthhee fflluuoorroocchheemmiiccaallss iinn bblloooodd pprrooggrraamm..
4
The serum organic fluorine level of the individual who was
pprreevviioouussllyy
rreemmoovveedd
ffrroomm
fflluuoorroocchheemmiiccaall
eexxppoossuurree
when
when
his
his
Exhibit
| suum1204 mee
cote maven
Wad Avaiabl by 3M fr Inspection and Copying a Conficental formation Made Available by 3M for Inspection and Copying as Confidential Information:
SSuubbjjeectctttooPrPortoeteccttiivvee OOrrddeerrIInn PPaallmmeerrv.v. 33MM,, NNoo.. CC22--0044--65330099
7 3SMMAAC0D0S9S6T7T7T7S5
11220044..00000011
nsseoesrrsuuumnreoodrr.ggaanniiTcche ffllluueoovrreilinneewaslleevvfeeollundrroossteeo
to bteo
70 7405
ppm p+pm5
has recently been phpams. reTcheentlaymobuenetn
moefasFuCr-e1d4.3 inThehislevuerlinewaswasfoufnodundto tboebe45 22+0 5ugppmf.or Tahe24 ahmoouurnt
opferiFoCd-.143 in his urine was found to be 220 ug for a 24 hour
period.
"SSeeerrluuemncteoodrrggaaennmiipccloyffelleuusoorriiatnneeCollreedvvoeevllass, hhaaDvveeecatrrueercceenanttnlldyyCbbheeeemenonlimmteeeaa.ssuurreeIddn
on
on
sceolmepcatreidsonemwpiltohyeelsevealts Comredaosvuar,edDeicnat1u9r76 anadndCh1e9m7o7,litteh.ere Ihnas
bceoemnparLiistotnlewicthhanglee.vels measured in 1976 and 1977, there has
been little change.
whTeheere
serum organic fluorine mseearusmuroerdgainnic197~8luoprriinore
levels of 15 Chemolite employees tloevetlhseiofbe1i5 ngCheimnovloiltveed emipnlotyheees
wppfeaalrccuekkoaarggmiiiennneaggsutrooaeffkdenFFCCi--nr11e44c133o9..7n8tlypRRreeippsoeehraaottwetdommeeaastssohuumererieermmueebnnneettixssnpgecooftfiendvttohhleeeiivlrreedvassteieinrrouunnmtsheoorriggnaanniicc
Cflloeelvvnueetollra..innienaIItntnioaoorkrngeganannwiiircctehcellnieetnvvleoeyllrssgasnwwhieeocrrweeedfalalslusosomooreidhheiiugqnhheieesxrrpescutttshheaapnndecteeeexxldppeeevccattttoeeiddob..nes
in
the
7
?
OCGcfouaunsserteeaosmuioflfntatstthihewoehinlihlwigighhtbheiinrniooenrrvoggiraaeg~nwanienicidclcetleofvvleesuLleo]ser~iidi~nef sai~eesnr~y,us,sume:,srprbbeauucstttweedttrhheeetomeeanbndetteii.rrteehessAoett
softudryesuwlitlsl wbielldonbee artetveimepwteidngtotoseereliafteanyexpeorsru~rsewetroesmearduem. orgaAnic
sftluudoyrinweilllebveelsd.one attempting to relate exposure to serum organic
fluorine levels.
Eight serum sanplos from rural Eaingdhtinoserrguamnicsamfpllueosrinferomlevreulrsa.l
China were analyzed for organic ChOirngaaniwcereflaunoarliynzeedlevfeolrsorrgaangneidc
anrdoni0n.o0r0g4anipcpmfltouor0i.0n1e7 lpepvemlsa.nd Oirngoarngiacnicflufolruionreidelevleelvselsranfgreodm
0f.r0o4m4 0.t0o040.0p7p6m ptpom.0.017 ppm and inorganic fluoride levels from
0.044 to 0.076 ppm.
TTthhreeaceienppgiiddeeammbiioooulltoogg3yy500ssttupudedyyopliiess
still in progress. satndillinvionlvpersograebsosu.t
The study involves 1T00hedesattuhdsy. inSvoolvfeasr
ttrhaecriengdocasbountot35a0p0peapreoptloeboanwdhaitnvmolivgehst baobouctons1i00derdeeadthass. "uSnousufaalr
ctahuesrees doofesdenaotth"a.ppear to be what might be considered as "unusual
causes of death".
HH..CC.. very
Hodge conmented that data from this Hiomdpgoertacnotmmeanntdedthatthatthedatsatudfyromshotuhlisd
epidemiology study is beepidceamriroieldogyoutstucdayrefiuslly.
vCCferruriiryttteehrreiirimaaposrtsstaeeatttendtffoorarttnthhhdatbbtyyhheatttwhheoetuhlNeN.d.CCs..trIIua..dtyhessrhshohoauouclulcdldedpbbeetbedffaocotllalalroorwwifeeerdddo..mouttDhDrri..scarHHteooyfddpueggleeloyf.
ssfstttuuuurdddtiyyheesrff,oorrsbtuaiittddeeedntnthtiaitftfhyayititnnhghegeNhhuawumtomauianlondnhaheleraaalltCtthahhenrceeerfaffcfeceIcecnttpsssttitdttuahhtataenan
dfartoam tfhriosm wdoautlad fnrootm
atnyipemalof aagnriemea.l
studies, but that the National Cancer Institute would not agree.
SWuabdlaetAutsoaPbrloetbyec OrfdorernsnpePcailamnearvn.dWChopNyoi.ngCa2s.0C4o3f3i0c0ntal nformtn Made Available by 3M for Inspection and Copying as Confidential Information:
Subject to Protective Order In Palmer v. 3M, No. C2-04-6309
11220044..00000022
awac0se7775
3MA00967776
PF..AA.. UUbbeell ssuummmmaarriizzeedd
physicians regarding
aatheccoonnsvvieegrnrsisafatiticiaoonnncewwiittohhf
tstwwlooigMMhataylyoyo
eCCllleiinvniaictced
plhiyvesricieannzsymeregsatruddiiensg tinhe sosmiegnioffictahneceCheomfolsiltieghtelmyploeyleeevsa.tedNo
ddleeiffveiirnniitteeenzyccmooennccllsuutssuiidooinnesss
wienresomreeacohfedt,heeCxhceempotlittheatemtphleoyveaelsu.es
were reached, except that the values
Nwoere
were
vcveeorrmyypastslilibiglghehttllwyyitehelleetvvhaaetiteredhdaiasnntddoirinynososfommeeianlicnssotthaaonnlcceeissnwgweeesrtreieofnfe.elltttThtoe~ybbeecould
cnnooottmpammtaakikebeleaannyywitsshttaatttheeemmieernntthiuusnntlleoesrssys
otfhey ahlacdohoalchinagnecsetitoon.exaTmhienye
they had a chance to examine
the could
the
employees personally.
employees personally.
DDrr..
HHooddggee
wwaass
sshhoowwnn
aa
summary
summary
of
of
the
the
abnormal
abnormal
findings
findings
in
in
those
those
33M
eemmppllooyyeeeess
wwhhoo
hhaadd
kknnoowwnn
fluorochemical
fluorochemical
blood
blood
levels.
levels.
He was
He was
ggiivveenn aa ccooppyy..
TThhee
rreessuullttss
ooff
tthhee
pphhyyssiiccaall
examinations
examinations
done on Decatur and
done on Decatur and
CCoorrddoovvaa eemmppllooyyeeeess llooookk
vveerryy ggoooodd..
There does not appear to be
There does not appear to be
eevviiddeennccee ooff showed more
a a
wwoorrkk
related
related
abnormalities,
problem. The Chemolite employees bpruotbltehme. majTohreitCyhemofolittheeseempalpopyeeaersed
to
bbseehowrreeedllaamttoeerdde ttooabnaaorkkmnnaoolwwinntimmeeesdd,iiccaabllutpprrthooebbllmeeammjooorrritmmyeeddiioccfaatttiihooenns..e
apIptewaarsed thteo It was the
ccoonncclluussiioonn
ooff
tthhee
pphhyyssiicciiaannss
wwhhoo
ssuuppeerrvviisseedd
tthhee
examinations
examinations
that
that
tthheerree
ddiidd
nnoott
aappppeeaarr
ttoo
bbee
aa
pprroobblleemm
wwhhiicchh
could
could
be
be
identified
identified
as
as
wwoorrkk rreellaatteedd..
AAddddiittiioonnaall
aannaallyyssiiss
ooff
tthhee
ddaattaa
will
will
be
be
done.
done.
J3..AA..
PPeennddeerrggrraassss
rreevviieewweedd
data
data
on
on
workplace
workplace
concentrations
concentrations
of
of
vVaarriioouuss
fflluuoorroocchheenmiiccaallss
iinn
AAllaabbaammaa
aanndd
Minnesota
Minnesota
plants.
plants.
In most
In most
ccaasseess
tthhee
wwoorrkkppllaaccee
ccoonncceennttrraattiioonnss
of
of
fluorochemicals
fluorochemicals
are
are
low-lower
low-lower
cttahhraacnninssooogmmeeenstt.iimmeeFlwWueeoiirggohhceehddemaaivvceearrlaaggeesssaltrrseeccooammremmeenneddxeecddeptffiooorrnskk.nnoowwnnDueoorr tssouusstppheeeiccrtteedd
dcduausrscttiyynonngaaettnuusrr.ee
woFrlkupolraoccehemciocnac]entsraalttsionasreareexcehpitgihoenr.s.
workplace concentrations, are higher.
LeDvueelstoofthoenier
Levels of one
ooff
tthheossee
mmaatteerriiaallss,,
FFCC--114433,,
hhaavvee
been
been
reduced
reduced
to
to
an
an
acceptable
acceptable
Vvaalluuee..
WWoorrkk
iiss
uunnddeerrwwaayy
ttoo
rreedduuccee
eemmppllooyyeeee
exposure
exposure
to
to
other
other
fflluuoorroocchheenmiiccaall ssaallttss..
RR..AA..
NNeellssoonn
rreevviieewweedd
rreessuullttss
ooff
9900
ddaayy
ssuubbaaccuuttee
toxicity
toxicity
studies
studies
uussiinngg FFCC--9955,, FFCC--114433 aanndd PFHM--33442222..
Of these compounds FC-95 was the
Of these compounds FC-95 was the
mmoosstt ttooxxiicc..
IItt
pprroodduucceedd
ddeeaatthhss
in
in
the
the
monkey
monkey
at
at
4.5
4.5
mg/Kg
mg/Kg
and
and
iinn tthhee rraatt aatt 1100 mmgg//KKgg.. TTaarrggeett oorrggaannss haemopoietic tissue, stomach 2nd small
in the rat iinntetshteinrea.t
were liver weIrnemolnikveeyrs,
haemopoietic
the apparent
tissue,
target
orsgtaonmawcahs
atnhde
sumpaplelr
iGn.tIe.stitnrea.ct.
In
monkeys,
the apparent target organ was the upper G.I. tract.
SatePeas rae Palmar vi aCoagags oT Made Available by 3M for Inspection and Copying as Confidential Information:
Subject to Protective Order In Palmer v. 3M, No. C2-04-6309
11220044..00000033
s3MnoAo0s09e6r7r7r7t7
.
Thhee lliivveerr organs in
aanndd the
ppoossssiibbllyy rats fed
the kidney and G.I. tract were target Ft-h3e24k2i2d.ney InandtheG.Ic.asetraofctmwoenrkeeystartgheetre
wwoaarssganccshheemmiiinccaatllheeevvriiatddseennccfeeedooffFM-GG3..I4I..22.ttooxxiiIccniitttyyh..e case of monkeys there
FFCC--114433 pprroodduucceedd lliivveerr monkeys hematopoietic
changes in cthiasnsguees waisn
rats at the erfatfsectaetd thaet
highest dose. In hliegthhealstdodossees. andIn
mtohnekreeyswashemeavtiodpeoniceetiocf gtaissstureoinwatsesteifnfaelctetdoxiactitlye.thal doses and
there was evidence of gastrointestinal toxicity.
H.C. Hodge also presented his summary of results of the 90 day
Hs.tCu.dieHsodgoen wsetruedie1s.5onmg
aFlCs-o143p,resFeMn-t3e4d22 /FKCg-14f3o,r FFMC--3144232
hiasnd anadnd
suFmCm-9a5ry FFNC--394522
(oafttraecshueld)t.s (ianttatchheedr)a.t,
ofThetshee aTnhedse3
9l0evedlasy mlge/vKegls
wiiennretthhee1.5mmoonnmkkgee/yyK..g
fForor FCF-C1-4935 For FC-95
atnhdereFMw-a3s42m2meifnftehcetralte,velandin3 tmhge/Krgat
there was n~rueffect level in the rat
haanneddrennoo adpdapatetaaarsffoorrtoeessbtetiimmaanattiiinnnggdicaa atnnooioneeffoffefeccttlivlleeervveelleffiiennctttshhee fmmrooonnmkkeeFyyC..-95,
TFh4e-r3e022apapnedarsFC-t1o43beaatnalilnddiocsaetiolneveolfs liinvertheeffreacttsstufdrioems.FC-95,
FM-3422 and FC-143 at all dose levels in the rat studies.
1H..CC..
HHooddggee
qquueessttiioonneedd
wwhheetthheerr
ssoommee
of
of
the
the
toxic
toxic
effects
effects
observed
observed
iinn tthhee aanniimmaall ssttuuddiieess Surface active agents
might be due maireghtknboewnduteo
to tboe
low surface tension. cloawpabsluerfaocfe catuesnsiinogn.a
Sppurrroofbballceeemm
ainctitvhee
in the
gaugte.nts Itarewasknopwonintteodbeoutcaptahbalte soofmecafulsuionrgochaemicals
gut. It was pointed out that some fluorochemicals
aarree
tthhee
mmoosstt
potent
potent
surfactants
surfactants
known.
known.
FF.LAA.. GGrriiffffiitthh observed with
pointed out that toxic effects such as those pFCo-i0n5t,edFoWu-t342t2hatandtoxFiCc-1e4f3feacrtes csoumcmhonaswitthhosseurfactants.
observed with FC-95, FM-3422 and FC-143 are common with surfactants.
R.A. Nelson pointed out that the liver effects are probably
Rr.eAv.ersNiebllseo.n pointed out that the liver effects are probably
reversible.
~-~~
H.C. Hodge pointed out that a buildup of fluoride ion can be \ Lik
dGoHf.eeCtt.eafcclttHueeoodddrgoenmcoohvpseetomiincrrtaaaelppdsiiddiolyyuttoiinntfhlauttthhoeeraidbbeobonnueeii..lodnupTcThhouuoussfldeefvbvleiiuddoeredinnedccteeeectooieffodnbbrrcieaennaakktbddhoof eewwnn% e .\_i_e) F
moofref,luorsoonceh.emsihcoaullsd
betoccooflllllueeorccittdeeedd
at the end of a chronic study ion could be detected in the
at the end of a chronic study
bony,
bone. Bone should be
aanndd aannaallyyzzeedd ffoorr ~flluuoorriiddee..
4
f
by
omntt
H5..CC.. Hllooddggee wwaass tthheenn aasskkeedd ffoorr
his recommendations on future work.
his recommendations on future work.
Aftera brief review of customer exposure to 34 fluorochemicals
ADfr.terHodagebrireefcomrmeevnideewdofthecusftoolmleorwinegx:posure to 3M fluorochemicals
Dr. Hodge recommended the following:
Made Available by 3M for Inspection and Copying as Confidential Information:
SiePratOredecapvasr vG3 a at3000 + HN Subject to Protective Order In Palmer v. 3M, No. C2-04-6309 1204.0004 1204.0004
s3MnoAo0s09e6r7r7r7e8
1. IItt ddooecss nnoott aappppeaarr tthhaatt tthher~e iiss aa ttooxxiicciittyy pprroobblleemm oouuttssiiddee 33MM.. fIlIoowweevveerr wwee ddoo nnoott kknnooww iiff tthheerree aarree ttooxxiicciittyy pprroobblleemmss Qduuee ttoo eemmppllooyyeeee eexxppoossuurree.. RReedduuccttiioonn iinn eexxppoossuurree sshhoouulldd hhaavvee ttooppprpirioorriittyy..
2. MMeettaabboolliicc iinnsstteeaadd ooff cchhrroonniicc ssttuuddiieess sshhoouulldd bbee ddoonnee nneexxtt.. SSeeqquueesstteerriinngg kkiinneettiiccss aanndd mmeettaabboolliitteess sshhoouulldd bbee llooookkeedd aatt..
3. RReepprroodduuccttiioonn ssttuuddiieess,, iinncclluuddiinngg tteerraattoollooggyy,, sshhoouulldd bbee ggiivveenn hhiigghh pprriioorriittyy.. TTwwoo ggeenneerraattiioonnss sshhoouulldd bbee uusseedd.. SSuucchh ssttuuddiieess sshhoouulldd ttaakkee lleessss tthhaann oonnee yyeeaarr..
4. CCaarrcciinnooggeenniicciittyy ooff fflluuoorroocchheemmiiccaallss sshhoouulldd bbee llooookkeedd aatt.. SSttaarrtt wwiitthh AAmneess tteessttiinngg aanndd ccoonnttiinnuuee ttoo mmoorree ssoopphhiissttiiccaatteedd mmuuttaaggeenniicciittyy tteessttss.. ILff_aannyy ooff tthheessee ttuurrnn oouutt ppoossiittiivvee ~tjt wwiillll bbee nneecceessssaarryy ttoo ggoo oonn ttoo aa cchhrroonniicc ssttuuddyy..
RR..AA.. NNeellssoonn qquueessttiioonneedd tthhee rreelliiaabbiilliittyy ooff tteesstt ootthheerr tthhaann tthhee AAmmeess.. TThhee ttrraannssffoorrmmaattiioonn tteesstt mmaayy bbee oonn tthhee wwaayy oouutt.. DDiiffffeerreenntt rreegguullaattoorryy aaggeenncciieess aarree nnoott ggeettttiinngg rreessuullttss wwhhiicchh aaggrreeee.. MM..TT.. CCaassee oouuttlliinneedd pprrooppoosseedd ssttuuddiieess oonn FFCC--880077 aanndd ssttuuddiieess bbeeiinngg ccoonnssiiddeerreedd ffoorr FFCC--9955 aanndd FFCC--114433.. ((SSlliiddeess aattttaacchheedd)) AA qquueessttiioonn wwaass rraaiisseedd oonn tthhee FFCC--880077 ssttuuddyy aass ttoo wwhheetthheerr tthhee FF..DD..AA.. sshhoouulldd bbee aasskkeedd aabboouutt tthhee pprroottooccooll.. IItt wwaass ssuuggggeesstteedd tthhaatt wwee sshhoouulldd pprroocceeeedd wwiitthhoouutt ccoonnssuullttiinngg tthhee PF..DD..AA.. ssiinnccee tthhee ssttuuddyy iiss sscciieennttiiffiiccaallllyy vvaalliidd.. RR..EE.. OObbeerr oouuttlliinneedd ppllaannnneedd wwoorrkk iinn tthhee mmeettaabboolliicc aarreeaa..((SSlliiddeess aattttaacchheedd)) TThhiiss pprrooppoosseedd wwoorrkk iinnvvoollvveedd mmeettaabboolliissmm ooff FFCC--880077,, ppeerrssiisstteennccee ooff FFCC--9955 aanndd FFCC--114433,, aanndd sskkiinn aabbssoorrppttiioonn ssttuuddiieess.. IItt wwaass ssuuggggeesstteedd tthhaatt HH..CC.. HHooddggee bbee ggiivveenn mmoorree ttiimmee ttoo ccoonnssiiddeerr tthhee pprrooppoosseedd sslliiddeess oonn FFCC--880077,, FFCC--9955,, FFCC--114133 aanndd tthhee mmeettaabboolliissmm wwoorrkk bbeeffoorree bbeeiinngg aasskkeedd ffoorr aann ooppiinniioonn..
SMMuaabddjeeecAAtvvtaaoiillPaarbbollteeecbbtyyiv33eMMOrffodorerrIInnIssnppePeccattilioomnneaarvnn.dd3CCMo,oppNyyoii.nngg2a-ass04CC-oon5nf3fii0dc8eennttiaall IInnffoorrmmaatitioonn::
Subject to Protective Order In Palmer v. 3M, No. C2-04-6309
11220044..00000055
33MMAA00000966T7T77799
ADDSNDUM
I called Dr. Hodge on April 20, 1979 to give him the acute oral toxicity data on FC-95, FC-143 and FM-3422 which was generated at IRDC prior to the 90 day studies. He asked that the following be added to the meeting minutes:
The study of levels of FC-807 or its metabolites is of utmost importance in determining possible future problems. It should be determined if FC-807 or its metabolites are present in man, what level they are present, and the degree of persistence (halflife) of these materials. If the levels are high and widespread and the half-life is long, we could have a serious problem.
i. RAP/ko
Attachments
MMaaddee AAvvaaiillaabbllee bbyy 33MM ffoorr IInnssppeeccttiioonn aanndd CCooppyyiinngg aass CCoonnfificdeenntitiaall IInnffoorrmmaatitioonn::
Subject to Protective Order In Palmer v. 3M, No. C2-04-6309
11220044..00000066
33MMAA0000996677778800