Document GmBooN27ZJGp7wL50bENgYYv

I.VMt lI. O A T lO N r x O H * Dept, of Medicine & Environmental Health B .G .Ward o'T- February 25, 1981 Analysis of Biological.Samples for tetrachlorodibenzo p-dioxin (TCDD) J. T. Garrett G. W. Buttler TO George Roush, Jr. -- 1 L, m At this time facilities capable of analyzing biological samples for the 2,3,7,8 isomer of TCDD are as follows: 1. Prof. Michael L. Gross, Director Midwest Center for Mass Spectrometry University of Nebraska - LincoiTT Department of Chemistry ( Lincoln, NE. 68588 SUBJECT TO PROTECTIVE ORDER. Tel. (402) 472-3507 (Assistant Director: Phil Lyon) Dr. Gross has been involved in federal government agency and industry work over a period of four years. His group has analyzed a broad range of biological samples of human origin. Until 1979 his analyses were TCDD specific, but not specific for the 2,3,7,8isomer. His group now has the capability of quantifying the spe cific isomers down to ppt levels in s u i t a b l e ^ n j a t r i c e T h e y have experience in spiking and recoverv of both C and C x 2,3,7,8TCDD. 2. Prof. Thomas Tiernan The Brehm Laboratory Wright State University Fairborn, Ohio Tel. (513) 873-2202 and 2203 (Joe Solch) This group was extensively involved with the Air Force on the Agent Orange project for monitoring 2,3,7,8-TCDD in blood. Their expertise is in blood work. The project has been severely reduced since 1979 due to changes in interest within the laboratory. 3. Profs. Rudi Buser & Christopher Rappe University of Umea Sweden World class capability on all types of human samples. Provides samples of all 22 isomers of TCDD in high purity to all workers involved in this analysis. High credibility. At this time the Ultratrace Laboratory at MRC, Dayton is reluctant to perform analyses on biological samples. Certain exceptions have been made in the past such as research interest projects; e.g., monkey milk 02S48 G001795 IN-10M ( R E V 2/78) ' "N #- -* George Roush, Jr. Page 2 and monkey embryos for PCB's, but there is little interest in pro viding a commercial or routine analytical service for such samples. Despite this, their technology and expertise appears to have developed to world class level. Brian G. Ward mlw f GOO 1796