Document GKbkjMgKMZ18oX2KXn3EEQOJY

Juno 27, 19314. Mr. C. Willoughby S* I. duPont do Nemours and Co. Chemical Department Experimental Station Wilmington* Delaware Dear Mr. Willoughby: Your letter to Dr# Kehoe of June 13th has been turned over to me as Dr# Kehoe eill be away this coming suaroer# We note that Dr# Kraemer is attempting to base his clinical treatment with colloidal lead on the blood lead-level* apparently using that as a guide to dosage# As Dr# Kehoe has reported, the blood lead-level is a variable factor and we have not enough data to establish the, normal variation except, as you have probably noted, enough to form an opinion that the normal is In the neighborhood of 0.05 mgs# per 100 ccs# ; Prom the studies of Weyraueh and others it would appear that there in considerable variation in individuals and in groups as well as a probable partition between plasma and cells# In '/lew of the possibility that lead is associated with the phosphorus in the blood s treaa, some worie certainly should be done to establish its partition# We have some references to work indicating that the lipoid phosphorus of the bio d is increased in lead poisoning, though no distributions of lead in blood in relation to phosphorus partition have been done as far as we know# You are quite welcome to such data as we have on the blood lead-level, and we will be glad to detail our method of preparing and treating samples if you so desire# It would seem, however, since you are dealing with an entirely different group of people that the best procedure after all might be to deter mine the normal level and range of variation for your own particular group# W would be happy to offer any suggestions for atfcack upon this problem if you will let us know exactly what you wish to do# Very truly yours. WFMjIS Willard F. Machle, k.D.