Document GKQnVyaNO60OOYk23zyDMyoQV

April 26, 1945 Mr. U. Bowes, President American Structural Products Company Toledo 1, Ohio * Dear Ur. Bowes: I appreciate the frank comments in your letter of March SI and sense considerable disappointment on your pert concerning the manner in which our investigations were conducted and the results obtained. It is rsy impression tnat tils stems in large part from. certain administrative and financial difficulties precipitated porhsos by mutual misunderstanding. I ui. ^naole to identify a. weakness in our scientific approve and mu.t take exception to your view that reports of value to you here not oeen forthcoming. It disturbs me greatly to have you entertain any degree of disappointment concerning our studies apropos the biological activity of an industrial dust* There fore, I should like to present a summary of our effo:ts in your behalf and trust that It will influence you to change your views# 1. February 2, 1943 - Two samples of "Hydrous Calelua Silicate1* (Rotocloae . Dust and Sander Dust} - received from Owens-Illinois Glass Co* 2# May SI# 1944 - Report submitted by the Saranac Laboratory identifying the in vestigations made and the results thereof. (1) Botoclone Dust: . a* X-ray diffractions tudies b* Fetrograpnlc studies e* Animal assays ?ige 2. Sr. U. Bow** April 26, 1940 _ (2) Sander Dust: a. I-ray diffraction studies b. Petrographic studies c. Aniscl assays 5. June 17, 1944 - Kecelved & check for this service................................$250.00 Extended Studies 1. December, 1944 - Authorised to pro ceed vita investigations'at $5,000. per veil. 2. rebrutr;;, 1940 - -xporlncnt; started. 0. *ey 10, 1345 - First report sum;vted . giving evidence that inhaled haylo fails to proi-ce pulmonary fibrosis. A'o evidence of effect on an asso ciated tuberculous infection. 4. October, 1046 - Death of Doctor Gardner, 5. February 5, 1947 - Visit by Hr. Hazard and Doctor Shook to determine status of investigations. 6. October SO, 1947 - Second report submit ted. Conclusions: Kaylo acts as an inert dust when inhaled into the lunr. Its Influence on a tuberculous Infection Is equivocal. 7. January S, 1943 - Beeeived a check for.................................................... 15,750.00 to eover period of investigations from February 15, 1945 to Soveaber 15, 1947, ). "inclusive (refer ay letter December 12, 1947 The investigations to date shoe rather eonolusively that Eaylo la an inart diat per se and Incapable of pro ducing a fibrosis on inhalation into the lung. This in formation la of.definite value even though me cannot as yet give assurance that Caylo falls to stlaulate a tubercu loua protest in the lung. Z have every expectation that our eurrent studies will enable a very definite opinion in that regard. r- /' Page 3. t ttr* U. Bowes April 26, 1945 ** I agree that our investigations have takon a long time, but the nature of the studies dictates prolong;: observations to make as certain as possible the poten tialities of the dust when inhaled into the lungs. Tuir. can be determined only after months of observetion. ]o must bo so by reason of the fact that the dr.ily increment' of dust localised in the lungs by inhalation ar6 of very low magnitude and the Inflammatory response of tne pul-* nonary parenchyma to such localisations Is eo slur;.:i i5?lievo r,et it demands extreme potience on our part volt until the desired period of time has elapsed to warrant positive conclusions coneerring the p; ter.tial toxicity of dust when inhaled. I as certain, Mr. Bowes, that you are aware of t:ie above an*, that you appreciate also the impossibility of forecasting either the results of research or th timr nscessfcry to conduct it. All re car. hop'^ for i; l confidence t!;at the investig* tiona rill b* nursu^s ts rsyidly a.%u efficiently as poasiolo. Again, Mr. Bowes, I would be pleased to hrvs your comments, tfe are proceeding witw the investiga tions in accordance with your authoritetion. Sincerely yours. AJV:I3 CC; Mr. W.*G. Uaeard Arthur J. Vorwald, M.D. Director of Research ^ o: ;r;7