Document G8K9do7y5Mvmr6wLQB3VrnZV

ST0853I 92 PLAINTIFF'S EXHIBIT POISONING DOW-1629 A Guide to Clinical Diagnosis and Treatment S E C ON D EDITION By W. F. von Oettingen, M.D., Ph.D. National Institutes of Health, U. S. Public Health Service U. S. Department of Health, Education and Welfare W. B. SAUNDERS COMPANY Philadelphia 1958 London o? I ST0853I 93 1958, by W. B. Saunders Company Copyright under the International Copyright Union All Rights Reserved. This book is protected by copyright. No part of it may be duplicated or reproduced in any manner without written permission from the publisher. Made in the United States of America. Press of W. B. Saunders Company. Library of Congress Catalog Card Number: 58-6405 ST0853I94 DEDICATED TO The Many Physicians Whose Observations and Reports Have Enriched Our Knowledge of Poisonings ST 0853 I 95 Preface to the Second Edition IJuring the six years which have elapsed since the appearance of the first edition of "Poisoning" new types of poisoning have been reported, new methods for the detection of toxic materials in biological specimens have been devised, and new procedures for the treatment of poisonings have been proposed. The introduction of numerous new thera peutic agents, some with potentially dangerous side effects, has necessitated a more detailed description of these side actions which do not represent actual poisonings, but the knowledge of which is of vital importance to the correct diagnosis and the proper treatment of the patient. On the other hand the list of chemicals and poisons causing certain functional changes have been revised and an attempt has been made to restrict these to the more charactcrisdc symptoms and to omit minor ones. It is hoped that these changes will increase the usefulness of the book. It is again an agreeable duty of the author to thank the- library staff of the Nadonal Institutes of Health for their untiring help in supplying the exten sive literature. Last, but not least, thanks are due to the publisher, W. B. Saunders Company, for assuming the publication of this edition. W. F. von Oettingen Bethcsda, Maryland v ST0853l96 Preface to the First Edition While death is the most dramadc manifestation of poi soning, subacute and chronic poisonings are far more common and often offer serious problems for diagnosis, which in turn determines the treatment of the patient and the prognosis of his condition. The incidence of poisoning, both acute and chronic, is constantly increasing as new chemicals for the most diversified purposes are placed on the market and are used in homes and industry. There are also many plant poisons which are of concern in rural districts, and finally there arc many drugs on the market which may produce side reactions of varying severity. There are literally hundreds of substances in use or to which one may be exposed today which may give rise to poisoning. Some of these toxic syndromes closely simulate infectious or functional diseases, and it is therefore of paramount importance that they be recognized. It is the purpose of this book to organize today's knowledge of the sub ject in a fashion which will most readily aid the general practitioner and the internist in diagnosis and treatment of poisoning. It is earnestly hoped that the material has been so arranged that it will save time for the busy physician in tracking down the toxic agent and instituting effective treat ment when poisoning is suspected. The book is divided into four parts. The first discusses the classification of poisons, the medico-legal aspects and responsibilities of the physician and the emergency measures and equipment necessary for the treatment of poisoning. Part two takes up the clinical diagnosis of poisoning. Here it is shown how diagnosis is based on the patient's history and the structural and functional pathology observed in the course of'a medical examination. The signs and symptoms are classified by body systems for ease of reference, and are dis cussed one by one as they present themselves in the course of a clinical exami nation. Under each is an alphabedcal list of toxicants which may be responsi ble for such a change. The physician will first turn to this section when confronted with suspected poisoning, finding under the symptoms he has observed a list of toxic substances which may give rise to them. In this section of the book there are also chapters on blood and urine vii ST0853I 97 ,nu ,<> iiit i-iksr iDtnoN changes in poisoning and on laboratory tests which are within the compass of the private practitioner or small hospital facilities. In part three each step in the management of poisoning is taken up separately. Emphasis is placed on the technics available for removal of toxic agents and on the symptomatic treatment which must often be employed at the same time or even preceding removal of the poison. The final and largest section of the book is an alphabetical listing of poisons. Under each poison is a short synopsis of the clinical picture and the treatment required. This arrangement is made with an eye to convenient reference by the practitioner. The section is based on the analysis of several thousand case reports. The book aims to supply in a single source the information needed by the clinician for the accurate detection and successful treatment of poisoning. Therefore, it does not cover the mechanism of action of various poisons, nor does it cover the animal experimental studies which were undertaken to study these mechanisms. For more detailed study of toxic agents the reader is referred to the various review articles mentioned in the text and to the larger text books of pharmacology. If this book helps the harried practitioner to detect poisonings more quickly and to take effective measures it will have achieved the author's aim. The author is indebted to Mrs. Florence B. Hall and Mr. A. F. Collins and other members of the staff of the library of the National Institutes of Health for their untiring help in furnishing the many journals and texts required for the preparation of this book. Finally thanks should be given to the publisher for encouraging the writing of this book. W. F. von Oettingen Bethesda, Maryland ST0853I 98 Glossary of the Abbreviations Used in the Lists of Poisons acute pois. acute poisoning occ. severe ac. high cone. asp. -- acute poisoning with high concentrations -- aspiration oral overdose parent. chron. chronic poisoning chron. early = early in chronic poison ing chron. late cone. sol. r= late in chronic poison ing _ concentrated solutions cont. expos. -- continued exposure cont. use -- continued use cion. clonic pois. prol. prol. use prot. rare rep. rep. oral exc. closes hypersens. ind. expos. = excessive doses -- hypersensitivity = industrial exposure sev. sol. subac. inhal. i.v. i.v. rare late lg. dose light = by inhalation , =r with intravenous injec tion _ rarely seen after intra venous injection _ late effect = after large doses -- in light poisoning sud. syst. trans. tonic worn. Page ix -- occasionally in severe poisoning = after oral doses -- after overdosage after parenteral admin istration = in poisoning in prolonged poisoning -- after prolonged use in protracted poisoning -- rarely observed = after repeated doses = after repeated oral doses = in severe poisoning -- soluble or solution -- in subacute poisoning -- after sudden intraven ous injection -- with systemic poison ing -- transitory phenomenon -- tonic convulsions = observed in women ST0353I93 Contents PART I. INTRODUCTION CHAPTER 1 Classification and Diagnosis of Poisoning............................................. 2 CHAPTER 2 Medico-Legal Responsibilities ................................................................. 5 CHAPTER 3 Emergency Measures and Equipment................................................... 10 PART II. DIAGNOSIS CHAPTER 4 Taking the Patient's History................................................................... 16 CHAPTER 5 Structural and Functional Pathology..................................................... 20 CHAPTER 6 Biochemical Changes .................................................................................. 124 CHAPTER 7 Laboratory Tests ........................................................................................ 135 XI MI CONTENTS ST 0853200 PART III. MANAGEMENT CHAPTER 8 The Rationale of Treatment .................................................................. 178 CHAPTER 9 Removal of the Toxic Agent.................................................................... 180 CHAPTER 10 Elimination of the Toxic Agent.............................................................. 186 CHAPTER 11 -.I*- v `m Detoxification of the Absorbed Poison................................................. 189 CHAPTER 12 Symptomatic Treatment ........................................................................... 190 CHAPTER 13 General Measures: Treatment of After-Effects................................... 203 PART IV Symptoms and Treatment of Various Types of Poisoning and of Toxic Reaction of Drugs ........................ ......................................... 205 Index 601 ST085320I PART ONE Introduction "V.*- CHAPTER 1 ST0853202 Glassification and Diagnosis of Poisoning The correct diagnosis of poisonings or of toxic conditions has become increasingly important. It is not only essential for the prompt and effective treatment of the patient, but in addition it may have other farreaching consequences. It may be of forensic importance and lead to the detection of a crime, or it may be instrumental in improving inadequate sanitary conditions and thus prevent later cases of a similar nature. The prompt recognition of a toxic condition which is due to the occupational environment may be of considerable economic importance for the patient in that in these cases the treatment of his illness and the resulting loss of gainful activity may be paid for through compensation by state and private insurance agencies. As stated by many experts, the incidence of poisoning, especially among children, has increased during the past years as the number of substances to which modern man may be exposed is constantly growing. The importance of some poisons as causative agents for suicide and for accidental poisonings has_ varied, especially as new chemicals have become readily available, while others like carbon monoxide and certain plant poisons have caused havoc for thousands of years. At one time poisonous antiseptics, such as phenol and cresol, were the prevalent cause of poisonings. The introduction of essence of vinegar for domestic use in certain countries has caused numerous fatal and nonfatal accidents. With the advent of illuminating gas and more recendy with the widespread use of the automobile, carbon monoxide poisoning has become much more prevalent than in the past. The unrestricted sale of sedatives and soporifics such as the barbiturates has caused an appalling number of fatalities from the intentional or accidental ingestion of these drugs. Similarly industrial poisons have varied considerably in their im portance as causative agents. Sometimes their dangers are recognized and controlled in certain trades and operations, but they may be used in new processes under different conditions where their danger is not so apparent or even not suspected. The same holds true for toxic substances sold for domestic use such as solvents, spot removers, insecticides, deodorants, and antiseptics. It is therefore apparent that the physician may be confronted with a great variety of toxic agents. Very often the medical examiner is unaware that a poisoning is the under 2 CLASSIFICATION AND DIAGNOSIS OF POISONING 3 ST0853203 lying cause for the condition of his patient and even more frequently he is not familiar with the toxic agent and its toxicologic properties. The clinical picture of parkinsonism may be the outcome of chronic manganese poisoning or of exposure to carbon disulfide. A Korsakow syndrome may be due to alcoholism, but may also be the consequence of carbon monoxide poisoning. Hepatitis may be of infective character or it may result from exposure to hepatotoxic agents such as carbon tetrachloride. On the other hand, the physician should not be misled in his diagnosis by impressive and widely publicized reports on the toxicity of certain chemicals. For it is just as dangerous to interpret erroneously a clinical picture as the result of exposure to certain compounds. For instance DDT, which has been publicized as being responsible for a great variety of pathologic conditions, had in most instances actually no relation to the condition of the patient. It is obvious that such mistakes may have far-reaching consequences in that the true cause may require a different therapeutic'approach. It has been customary to classify toxic substances according to their most characteristic action, such as nerve, liver, or blood poisons. Such arrangement may have certain advantages in that it affiliates specific toxic substances with specific pathologic conditions. But on the other hand, there is no poison which affects one organ only. Sooner or later, primarily or secondarily, other organs will be affected and in some instances these inj uries may predominate, so that a liver poison like carbon tetrachloride may cause an obvious injury of the kidney or may be responsible for dysfunctioning of the heart muscle. In other instances the sequelae of acute exposure may refer to one organ, and those of continued exposure to another. The inhalation of high concentra tions of benzene vapors results predominantly in disturbances of the central nervous system causing headache, inebriation, somnolence, loss of conscious ness, and occasionally convulsions. Chronic exposure to the same agent will cause a more or less severe inj ury of the blood-forming organs and will lead to leukopenia and anemia. It is therefore obvious that such classification is not striedy justified. Others have arranged toxic substances according to their chemical charac teristics such as aliphatic and aromatic hydrocarbons, chlorinated hydro carbons, alcohols, phenols, alkaloids, glucosides. Such classification may en hance the understanding of the mechanism of their action and may allow the appraisal of the toxicity of chemicals with known chemical structure. However, it does not lend itself for the clinical diagnosis of poisonings unless one is familiar with the toxic phenomena of a great many different toxic substances. It appears impossible that a physician can keep in mind all signs and symptoms of toxic substances. For this reason in the following pages an attempt is made to give a patho logic physiology of poisonings by describing the observable pathologic changes in different organs and organ functions as produced by various poisons. A similar approach has been successfully used by H. H. Meyer and R. Gottlieb in their Experimented Pharmacologic and by L. Krchl in his 4 ST 0853204 INTRODUCTION Pathologischc Physiologic. It is hoped that the comparison of abnormal find ings as they present themselves in the course of a systematic clinical examina tion of patient, and their classification by toxic causative agent or groups of agents, will allow the elaboration of the toxicologic picture and thus lead to the diagnosis of the poisoning in question. In accordance with this plan the actions of toxic agents are discussed with reference to their effect on organs and organ functions which are noticeable upon inspection, or which refer to the respiratory apparatus, the circulatory system, the gastrointestinal tract, its glandular structures, the urinary ap paratus, glands of internal secretion, the central and peripheral nervous sys tem, the sensory functions, and the blood-forming organs. This is followed by a discussion of changes in the blood chemistry and in the composition of the urine as produced by various poisons, and by a number of tests for the detection of toxic substances or their metabolites in blood and urine. In the last part a short synopsis of the clinical pictures of various poisonings and side actions of drugs is given, in order to summarize the various organ find ings. In these descriptions the symptomatology is discussed somewhat sum- marily because the signs and symptoms produced by certain organ changes may vary in their frequency and intensity from case to case. It is felt that too detailed a description would run the danger of becoming a case history, and that a broader picture would emphasize certain definite characteristics where as details may vary from case to case. Similarly the management of poisonings is discussed from the point of view of organ functions rather than of individual poisons. In those instances where specific measures have been found of value they are discussed in the last part under the particular poison. It is hoped that such an approach will facilitate the diagnosis of poisonings and allow an effective treatment even in those cases where the underlying cause has not been established. CHAPTER 2 ST 0853205 Medico-Legal Responsibilities As in any disease, it is the duty of the physician attending a case of poisoning to save the life of the patient, to make him comfortable, and to protect him against further injury. Beyond this he has additional responsibilities. In certain cases the poisoning may indicate a danger to`` the general public, as in the contamination of drinking water or the pollution of the air by toxic gases or fumes. In such instances the public health authorities have to be notified at once so that steps may be taken to remedy the situation and to prevent further accidents. The occurrence of other poisonings, such as cadmium poisoning, may point to the appearance of cooking utensils and other food containers on the market which are plated with cadmium and it is obvious that the public should be warned against their use. The poisoning may result from the inges tion of food or food products contaminated with toxic materials used as preservatives, food dyes, and other agents added to make the food more appealing. Poisonings may result from the domestic use of insecticidal mix tures, dry cleaning agents, floor waxes, and similar materials which contain toxic substances. In all such cases it becomes the duty of the physician to notify the proper authorities so that appropriate action may be taken. Similarly poisonings of an occupational character have to be reported in order to avoid accidents of similar nature and to secure for the patient the benefits provided by law. The laws and regulations regarding the reporting of occupational poison ings and diseases vary with different states of the Union. The most recent compilation on this subject is that of V. M. Trasko (Occupational Health and Safety Regulation. U. S. Dept, of Health, Education and Welfare; Public Health Service. P. H. S. Pub. No. 357, 1954). According to this source industrial diseases including poisonings are reportable in 29 states as listed in Table 1. It will be noted that these Have to be reported to different agencies in different states. It is, therefore, advisable to familiarize oneself with the local state laws and regulations regarding this question. Some states publish lists of those occupational poisonings which have to be reported by the examining physician and may add to and change such lists as the necessity arises. Table 2 is compiled from the publication of W. Fowler (The Reportable Diseases. Pub Health Rep. 59:317, 1944) and shows which occupational poisonings were reportable in certain states at that time. It 5 6 ST 08 53206 INTRODUCTION should be pointed out that in some states the term "benzene poisoning" may also cover poisonings by nitro, hydroxy, and amino derivatives of benzene, and that in addition to poisonings from carbon tetrachloride, those by other organic halides or solvents are reportable in others. Table 1. State Agencies to Which Occupational Poisonings Should Be Reported STATE AGENCY BEUA&KS Alabama State board of health, county and state health officer Arkansas State health officer California Division of labor statistics within 7 days Colorado Local health officer immediately Connecticut State dept, of health within 48 hours Georgia State board of health Iowa '' Local health officer Kansas State board of health Kentucky City or county board of health Louisiana Department of health Maine Dept, of health & welfare within 10 days Maryland State board of health Massachusetts Dept, of labor & industry Michigan State dept, of health within 10 days Minnesota State dept, of health within 5 days Mississippi County health officer Missouri Division of health within 24 hours Montana State board of health, div. of ind. hygiene New Hampshire State board of health within 48 hours New Jersey State dept, of health & dept, of labor within 48 hours (lead) New Mexico Local health officer New York Commissioner, dept, of labor Ohio State commissioner of health within 48 hours Oklahoma State dept, of health Pennsylvania State dept, of health & dept, of labor & ind. Rhode Island Dept, of pub. health South Carolina State board of health Utah State dept, of health Wisconsin State dept, of health Other states, as, for instance, Massachusetts, may require every physician treating a patient whom he believes to be suffering from an ailment or disease contracted as a result of the nature, circumstances, or conditions of the pa tient's employment, to report such information. The department may issue a list of such diseases which shall be regularly reported on by physicians and may also add to and change such lists at any time. Some states require the reporting of all cases of dermatitis from occupa tional exposure and others that of certain diseases connected with certain trades. So, for instance, Kentucky requires physicians to report petroleum MEDICO-LEGAL RESPONSIBILITIES $ T 08 53207 1 workers' diseases, such as respiratory, gastrointestinal, nerve, and eye dis orders. South Carolina requires reporting of poisonings from refrigerants such as methyl chloride, ethyl chloride, dichloroethylene, methyl bromide, ethyl bromide, methylene chloride, methylformate, dichlorodifluoromethane, dichloroethane, and sulfur dioxide. Poisonings of suicidal or homicidal character and accidental poisonings should be reported to the county coroner or medical examiner in every jurisdiction of the United States. It is obvious that these different responsibilities require considerable pre caution and extreme thoroughness on the part of the physician in order to safeguard the interests of his patient and, in many instances, also of the community at large. t ST 0853208 INTR0DUCTITM KISNOOSIM + +++ ++ ++NOXONIHSVAV + YNIlOaVD HXflOS +++ ++++ ++ + ! +i ONVisi aaoHa VXNVATASMNjtd + ++ + omo S30A AY3N ++ ++ + + 4- 031X311 AY3N & _c c A3SH3f AY3N .3 3HIUS<mVH AY3M 3 B ,o ixnossm M Iat, ouu3 VXOS3NXITI ++++ 4-4-4- 4- ++ ++ + 4-44- 4-4- 4- + oKviAavre 4- ja it auivrc 4- u Oi xsoniNas + +++ + 4-4-4-4-4- + 4-4-4- G4 15ju SVSNY3 4- 4-4- 4- VM.OI 4-4- 4-4-4- 4-4-4-4- 4-4-4- xaoixoaKMoo 4- oavaoioo VKV&VIV 4- 4-4-4- 4-4-4+ 4-4- 4- 44- U -D 2 2e *5zo a .a JS 5 8oa. 3 o o t> ~a v U "g "O 'E .2 .fl </> ti .2 2 S S .I-SS~t--C_c/}.a!4f)l cNC4)e.S3SO O* =t/>i G'-B'-B 3 r- n W b O E SO u w 22 -4-2r> 1<2> CJ OWC -CBk E um td e-i/i04>cacacccej2.c-c>* C4> CN *S TW3 J4>5J U 4) tt9ffSl rs rs .2 u -2 cd o -C u <2 ^*" 2 >e> 2 ->cw *(2<<<sauuouuuu(ju OS MEDICO-LEGAL RESPONSIBILITIES + 4- + ST0853209 9 + 4- 4- + + 4- ++ + 4- 4- + 4-4-4- 4-4- + 4- + 4-4-4- + + 4-4-4- + + + + 4-4-4- + + + + + 4-4-4- 4- 4- 4- 4- 4- 4- 4- + -L 4- 4- 4-4- + 4* 4- 4-4-4- + 4- 4-4- + + 4- 4-4-44- 4- 44- 4+ + 4- + 4- 4- +++*++ 4-4-4- 4- 4- 4- 4*4- 4* 4- + + + 4-4- 4- 4-4-4-4-4-4-4- 4-4- 4- 4- 4- 4- 4-4- 4- + 4-4-4- 4- 4-4-4-4-4- 4- + 4- 4-4- 4- 4* 4-4-4- 4-4- 4- <L> ^ j s3 5 M l-c 2 3 = cC ^ V .2 bO <4 Et _3 j<=J ,_ _ ' <M _ 2 -- <J ., 3 3U -- * >* -*j cU -=^rj -33 3Jims O 3 "S o 4> mc0boJC -OS-o2s. "oC--5 X 3.2 IS<r-t> OUC/2 '(SI 00 OCJ go ~.5u2Z i3 c"n3 X4u3 >3M 3(A <3u5 oj h cy3 3 r4 ue c 2 oc S ASBESTOS 247 -s-To8!m.extract (2 cc. daily intramuscularly) and dimercaprol (fiAL), 05 cc. every six hours for forty-eight hours and then 2 cc. daily for six doses intra muscularly, have been suggested. This medication should be combined with general supportive therapy such as the intravenous administration of 5 per cent dextrose to maintain the water balance, vitamin therapy, and oral hygiene. Arsphenamine encephalitis appears to respond prompdy to therapy with dimercaprol (BAL), and toxic hepatitis to acetylmethionine (Thiomc- don) given orally or intravenously. Beattie, J., and Marihall, J.: Brit. M. J., 1:547, 1944. Fiaher, S., Holley, and Fein, G.: Arch. Dermat, 55:57, 1947. Hanger, F. M., and Gutman, A. B.: Trans. Ass. Am. Physicians, 55:179, 1940. Hattersley, P. G.: Ann. Int. Med., 28:452, 1948. Shirbal, J. J., and Thurman, F. M.: Am. J. Syph., 19:17, 1935. Zierz, P.: Arch. Dermat., 190:463, 1950. Artane Artane (trihexyphenidyl hydrochloride; alphacyclohexyl-alphaphenyl-lpiperidinepropanol hydrochloride) is a crystalline material which decom poses at 258.5 C. and which is soluble in water and slightly soluble in alcohol. It is used in the treatment of paralysis agitans. Dryness of the mouth and blurred vision are not uncommon side reactions and nausea, dizziness, and confusion may be complaints. Large doses may give rise to hallucinations. Dohay, L. J., Constable, K,, and Zier, A.: J.A.M.A., 154:1334, 1954. Porteous, H. B. and Ross, D. N.: Brit. Med. J., 2:138, 1956. Asarum Asarum europaeum (Hasclwurz) is a small perennial herb which con tains aseronc (2,45-trimethoxy-l-propenylbenzene). The leaves of-the plant were formerly used as a diuretic, diaphoretic, purgative and emetic. Decocdons of the root were used to induce abortion. Its ingestion produces nausea, vomiting, diarrhea, and hyperemia of the pelvis. At least one instance of successful use of the plant for abortion is reported. Von Octtingen, W. F.: Nat. Inst. Health Bull., No. 190:324, 1949. Von Sury, K.: Munch, med. Wchnschr., 57:26, 1910. Asbestos Asbestos (magnesium-calcium-silicate) forms fine, slender, flaxy fibers and is used as an insulating material. The inhalation of asbestos dust causes asbestosis, which differs from silicosis by its slower development and a certain type of pulmonary fibrosis. The earliest symptom is dyspnea upon physical exertion, later accompanied by a harsh, nonproductive cough and fleedng pain in the chest. Most patients show a reduction of the vital  248 ASPIDIUM capacity, a satisfactory respiratory volume, and hyperventilation with a considerable increase of the respiratory rate. In more advanced cases anorexia and cyanosis may develop and there may also be emaciation and finger clubbing. Many asbestos workers show asbestos corns on their skin caused by hyperkeratosis around asbestos fibers which have entered the skin. Asbestosis is characterized by a diffuse interstitial fibrosis of the lungs with areas of catarrhal changes and the appearance of asbestos bodies in the sputum. It is a progressive disease with a bad prognosis for which there is only symptomatic treatment. Several authors have reported cases of cancer of the lung in asbestos workers, but their number is too limited to allow a statistical evaluation. Baitender, H., Denolin, H., DeCosta, A., and Englert, M.: Ann. mal. prof., 16:546, 1955. Behrens, W.: Schweitz. Ztschr. allg. Path., 14:275, 1951. Doll, R.: Brit. J. Indust Med., 12:81, 1955. Eliman, P.: J,.Ijpdust. Hyg., 15:165, 1933. Smith, K. W.: Arch. Indust. Health, 12:198, 1955. Aspidium Aspidium (male fern, Filix Mas) is used as an anthelmintic against tape worms. Toxic effects may be observed even with moderate doses and are characterized by irritation of the gastrointestinal tract or symptoms from the central nervous system. In light cases there is vomiting, colic, and diarrhea, followed by headache, dizziness, more or less marked dyspnea, yellow vision, and amblyopia. In severe poisonings the pulse is rapid and the patient may suffer from fainting spells and may pass into collapse. He may become delirious, suffer from muscle cramps, trismus, clonic and tonic convulsions, become comatose, and in many instances develop visual disturbances such as nystagmus, hemianopsia, amblyopia, and amaurosis. Psychosis may be observed occasionally. The liver may be affected, as in dicated by the presence of jaundice, and there may be some irritation of the kidney as indicated by the presence of albumin, casts, and sugar in the urine. Treatment. This consists of gastric lavage, saline cathartics, and enema. The irritation of the intestinal tract may be alleviated by demulcents. Otherwise the treatment has to be symptomatic. Hail, M. C.: J.A.M.A., 63:242, 1914. Selander, P.: Ann. Pcdiat., 173:259, 1949. Asterol dihydrochloride Asterol dihydrochloride (6-[betadiethylaminoethoxy]-2-dimethylaminobenzathiazole dihydrochloride; diamthazole dihydrochloride) is a crystalline material which decomposes at 269 C. It is freely soluble in water, methanol, and alcohol. It is used as a fungicide in the treatment of dermatophytoscs k SlUCA Shellac ST08532 I 2 533 Shellac (lacca) is a resinous exudate of the bark of various rcsiniferous species of Schleicheria, Butea, Ficus, and others, caused through puncture by the insect Coccus lacca. It is one constituent of lacquers and varnishes. The prolonged inhalation of the mist of such lacquers may lead to chronic exudative pneumonia with induration. Hirsch, E. F., and Russel, H. B.: Arch. Path., 39:281, 1945. Silica Silica (silicon dioxide) occurs in quartz, sand, flint, chalcedony, opal, agate, and Kieselguhr. It forms colorless, transparent, and tasteless crystals or a white amorphous powder. It is used in the ceramics industry, and it is one of the hazards ia^stone cutting, sand blasting, mining, casting, and other trades. Inhalation of silica results in silicosis, which is essentially a fibrosis of the lungs. Its onset is slow and insidious. In the beginning of the disease symptoms may be absent except for changes revealed by x-ray examination. After the process has fully developed, shortness of breath upon exertion, cough, and pain in the chest are the most common subjective signs. The dyspnea is not affected by the patient's position. The objective signs are shortness of breath, cough, prolonged expiration, altered breath sounds, and rales, impaired resonance, and the characteristic roentgenographic appearance of the lung fields; however, there is usually neither cyanosis nor clubbing of the fingertips. The blood pressure shows no appreciable rise, but there may be hypertrophy of the right side of the heart. Electrocardiographic records with chest-wall leads may demonstrate changes in the ST-segment and of the T-wave at a time when these are not demonstrable by the extremity electrocardiogram, and indicate an increased hemodynamic burden placed on the right ventricle. They may be observed in the absence of clinical symptoms of impaired' cardiac action. Other electrocardiographic findings are indicative of right ventricular hypertrophy, but these are not so much related to the silicotic process as to the degree of emphysema, which affects the action and the position of the heart. The silicotic process may arise and continue after discontinuance of the exposure to silica, and there is no therapy to stop the process. Persons suffering from silicosis are prone to contract tuberculosis. Trauma caused by some siheious substances, such as tglass fragments, may result after varying periods of time in the formation of granulomas at the sites of the original injury. They show a typical sarcoid reaction. Treatment. This consists in discontinuation of the exposure and sympto matic and supportive measures as indicated. Crossland, P. M.: A.M.A. Arch. Dermat., 71:457, 1955. Giering, J. T. and Charr, R.: J.A.M.A., 113:574, 1939. Hormann, J.: Zeicschr. KreislaufTorsch., 39:624, 1950. Sayers, R. R. and Jones, R. R.: Pub. Health Rep., 53-.-.1453, 1938. ST08532!3 Index Abamn, 213 Abdominal pain, 62 ' K v Abortion, 82 Abrin, 205 Abrodil, 388 Abrus precatorius, 205 Absintbe, 206, 524 Absinthium, 206 Abstinyl, 345 Acacia, 206, 595 Acacia Senegal, 206 Accelerators, 207 Accent, 369 Accommodation, loss of, 108 Acedicon, 207 Acetaldehyde, 208 detection, 135 Acetanilid, 208 detection, 136 Acetaniline, 208 Acetarsol, 209 Acetarsone, 209 Acetazolamide, 210 Acetic acid, 210 Acetic ether, 351 Acetone, 211 detection, 136 Acetone cyanhydrin, 212 Acetonitrile, 212 Actonuria, 132 3 - (a-Acetonylbenzyl) -4-hydroxycoumarin, 593 Acetophenetidine, 212 detection, 137 Acetphenarsine, 209 Acetyladalin, 213 N-Acetyl-N-a-bromo-a-ethylbutyrylcarbamide, 213 p-Acetylaminobenzaldehyde thiosemicarbazone, 471 determination, 162 Acetylaminobenzene, 208 Acetylaminobenzylidcne thiosemicarbazone, 477 2-Acetylamino-13,4 -thiodiazoie-5-sulfonamide, 210 Acetylaniline, 208 Acetylarsan, 333 N-Acetyl-N-bromodiacet/lurea, 213 Acetylcarbromal, 213 Acetylene, 213 Acetylene tetrachloride, 559 N-Acetyl-4-hydroxy-m-arsaniIic acid, 209 Acetylsalicylic acid, 213 Achromycin hydrochloride, 560 Acidosis, 126 treatment of, 201 Acid red, 347 Ackee, 264 Acne, 33 Aconitine, 215 Aconicum napellus, 215, 378 Acridine, 216 detection, 137 Acridine red, 347 Acrodynia, 34 Acrolein, 216 Acrylaldehyde, 216 Acrylonitrile, 216 Actedron, 228 ACTH, 312 Acthar, 312 Adalin, 286 Adanon hydrochloride, 424 Addiction, 94 Adermine hydrochloride, 515 Atlrenaline, 350 Adrenals, injury to, 83 Adrenocorticotropin, 312 Adsorbents, therapeutic use, 184 Aethusia cinapium, 346 Agate, 533 Agene, 459 Agotan, 305 Agranulocytosis, 122 treatment, 200 Agrostemma githago, 217, 527 601 * 602 ST08532 I 4 INDEX Albuminuria, 129 Alcohol, 352 Aldehyde ammonia, 207 Alder, 595 Aldrin, 217 Alepsin, 344 Aleudrine, 394 Alfalfa, 218 Alkali, 218 Alkali violet, 234 Alkavervir, 218 Aileron, 477 Alkylmercury, 219 Allium sadvum, 219 Allodene, 228 Alluritis cordata, 585 Allyl dibromide, 219 l-AlIyl-2,5-dimethoxy-3,4-methy!enedioxide benzene, 237 Allyl-isopropylacetyl-caibamide, 530 4-Allyl-l,2-methy!enedioxybenzene, 524 Allylsulfocarbamide, 572 Allyl-thiourea, 572 Alocaine, 511 Aloe, 220 detection, 137 Aloe ferox, 220 Aloe perryi, 220 Aloe vera, 220 Aloin, 220 Alopecia, 37 Alpha -chloralose, 289 Alpha-cyclohexyl-alphaphenyl-1 -piperidine- propanol hydrochloride, 247 Alpha-methylphenethylamine, 228 Alpha-naphthalene, 207 Alpha-naphthylthiourea, 220 Alpha-3-phenylnaphthylamine, 207 Aludrine, 394 Alum, 220 Aluminum acetate, 221 Aluminum ammonium sulfate, 220 Aluminum chloride, 222 Amanita muscaria, 222 Amanita pantherina, 222 Amanita phatloides, 223 Amanitine, 302 Amarsan, 209 Amaurobius ferox, 540 Amblyopia, 112 Amenorrhea, 82 American ivy, 479 American woodbine, 479 Amethocaine hydrochloride, 558 Amidon, 424 Amidryl, 343 Amino-anisole, 372 Amino-azotoluenc, 223 Amino-azobenzene, 347 Amino-benzene, 232, 347 p-Aminobenzenesulfonamide, 547 p-Aminobenzoic acid, determination, 162 p -Aminobenzoxy-1 -di-n-butylaminopropane sulfate, 270 Aminocresol, detection, 137 p-Amino-N-(2-diethylaminoethyl)-benzamide hydrochloride, 511 3-Amino-4-dihydroxy-arsenobenzene-methanalsulfoxylate, 448 p-Amino-dimethylaniline, 372 p-Amino-diphenylamine, 372 3-Amino-4-hydroxyphenylarsine oxide, 467 8- (4-Amino-1 -methylbutylamino) -6-methoxy- quinoline, 510 3-(4-Amino-2-methylpyrimidyl-5-methyl)-5-0hydroxycchylthiazoline hydrochloride, 568 2-Aminonaphthalene, 263 Aminonitrophenoi, detection, 138 2-Aminopentanedioic acid, 368 Aminophenol cthylether, 476 Aminophylline, 224 Aminopterin, 224 4- Aminopteroylglutamic acid, 224 2-Aminopyridine, 224 Aminopyrine, 225 detection, 138 p-Aminosalicylic acid, 472 determination, 162 2-Aminothiazol, 226 Amithiozone, 471 Ammonia, 226 Ammonium carbazotate, 228 Ammonium chloride, 227 Ammonium hexanitrodiphenylamine, 251 Ammonium picrate, 228 Ammonium sulfide, 228 Amnesia, 88 Ampelopsis heteracea, 479 Amphedroxyn, 424 Amphetamine, 228 determination, 138 Amygdalin, 230 Amyl acetate, 230 Amyl alcohol, 231 determination, 139 tertiary, 231 Amylene hydrate, 231 Amyl-mercuric chloride, 219 Amyl nitrite, 231 Anamirta cocculus, 502 Andira araroba, 304 Anecdne chloride, 545 Anemia, 117 aplastic, 118 hemolytic, 118 pernicious, 119 treatment, 200 Anertan, 437 Anesthesia, 102 Anethaine, 558 INDEX Aneurine hydrochloride, 568 Angioneurotic edema, 32 Anhalonium lewinii, 423 Aniline, 207, 232 detection, 139 Aniline black, 234 Aniline dyes, 234 Anisocytosis, 119 Anorexia, 61 Anoimia, 48 Antabuse, 345 determination, 154 Antallergan base, 515 Anthisan base, 515 Antib, 471 Antibason, 438 Antidotes, chemical, 181 Antifcbrin, 208 Antihistaminics, 234 determination, 139 Antimony, 234 detection, 140 Antimony oxide, 234 Antimony sulfide, 234 Antipyrine, 236 detection, 140 Antistine, 235 Antrypol, 554 ANTU, 220 Anuria, 79 Anxiety, 22, 86 Aphasia, 93 Aphonia, 50 Aphdria, 259 Apiol, 237 detection, 140 Apocyanum siriacum, 378 Apolopappus heterophylus, 362 Apomorphine, 237 therapeutic use, 180 Appetite, increased, 61 loss of, 61 Aprelosine, 378 Arbor vitae, 574 Areca catechu, 238 Arecoline, 238 Argemone mexicana, 238 Argemone oil, 238 Argentinan, 471 Argilla, 396 Argyria, 25 Armazide, 392 Arnica, 238 Arnica montana, 238 Arsacedn, 239 Arsanilic acid, detection, 169 Arsaphen, 209 Arsenical pigments, 242 Arsenic, 239 detection, 140 ST03532 I 5 Arsenic trichloride, 243 Arsenic trioxide, 239 Arsenic trisulfide, 243 Arsenious chloride, 243 Arsenious hydrogen, 243 Arsenobenzene, 245 Arsenuretted hydrogen, 243 Arsimina triloba, 245 Arsine, 243 Arsphenamine, 245 detection, 141 Artane hydrochloride, 247 Artemisia absinthium, 206 Artemisia maritima, 526 Arteriosclerosis, 60 Arthralgia, 101 Arthriticine, 503 Artificial respiration, 192 Arysanthium cinerariaefolium, 513 Asarone, 247 Asarum europaeum, 247 Asagrea officinalis, 589 Asbestos, 247 Ascaridol, 288 Ash, 595 Aspergillus fumigatus, 365 Aspidium, 248 Aspirin, 213 Asterol dihydrochloride, 248 Asthenia, 20 Asthma, 43 Atabrine, 576 detection, 166 Ataxia, 98 Atophan, 305 Atoxicocaine, 511 Atoxyl, 538 detection, 169 Atractaspis microlapidata, 536 Atropa belladonna, 249 Atropine, 249 detection, 142 Auditory disturbances, 115 Auditory acuity, decreased, 115 increased, 116 Auramine, 234, 250 Auranria, 251, 347 Aureomycin, 301 determination, 149 Auricular fibrillation, 57 Auripigment, 243 Aurothioaurocidin, 369 Aurothioglucose, 369 Aurothioglycanide, 369 Avandne, 393 Averdn, 578 determinarion, 174 Axerophthol, 590 Azalea mediflora, 378 Azalea pontica, 378 603 604 ST08532I 6 INDEX Azine, 349 Azoimide, 379 Azotriphenylmethane dyes, 347 Bacillus polymyxa, 506 Bacitracin, 251 Baku, 409 BAL, 337 determination, 153 therapeutic use, 188 Banana oil, 230 Banthine bromide, 427 Barbados nut-tree, 395 Barbenyl, 486 Barbiphenyl, 486 Barbiturates, 251 detection, 142 Barium, 255 Barium carbonate, 255" :' Barium chloride, 255 Barium oxide, 255 Barium sulfide, 255 Barracuda, 256 Bayer 205, 554 Bead tree, 413 Bee venom, 257 Beech, 595 Beech nut, 257 Bejuco de Pconia, 205 Benadryl, 235, 343 determinadon, 153 Benzalkonium chloride, 595 Benzanthrone, 258 Benzedrine, 228 Benzene,_258 detection, 143 Benzenehexachloride, 259 determinadon, 143 Benzethonium chloride, 260 Benzidine, 261 detection, 143 Benzine, 366 2- (Benzohydryloxy) -N,N'-dimethylethyIamine, 343 2 - (Benzohydryloxy) -N.N'-dimethylethylamine8-chlorotheophylIine, 337 Benzol, 258 Benzo-a-pyrcne, 261 Bcnzosulfimide, 523 Benzothiozon, 471 Benzoyl-pseudotropeine, 584 Benzpyrene, 261 Benzyl chloride, 261 2-[Benzyl-(2-dimethylaminoethyl)-amino]pyridine hydrochloride, 584 Berberine, 379 Berculon A, 471 Bergapten, 374 Bemacaine, 511 Beryllium, 261 determinadon, 144 Beryllium oxide, 261 Betabion, 568 6-( Betadiethylaminoethoxy) -2-trimethylamino- benzathiazole dihydrochloride, 248 Beta-methylacrolein, 316 Beta-naphthol, 207 Beta-naphthylamine, 263 Beta-quinine, 517 BHC, 259 Betel nut, 238 Betula oil, 437 Bichloride of mercury, 417 Bilberry, 588 Bile pigments in blood, 126 Bilineurine, 302 Bilirubinuria, 132 Biot's breathing, 43 2,2-Bis-(p-chlorophenyl)-l,l,l-trichloroethane, 323 Bis-(diethylthiocarbamyl)-disulfide, 345 Bishydroxycoumarin, 331 detection, 152 Bis-(p-hydroxyphenyl)-phthalide, 489 Bismarck brown, 347 Bis- (mono-isopropylamine) -Auorophosphine oxide, 439 Bismuth, 263 detecuon, 144 Bismuth subnitrate, 263 a, )-Bis-( trimethy [ammonium) -hexane dibro mide, 375 Bitter ash, 361 Bittersweet, 346, 539 Blaasoportoby, 565 Black balsam, 484 Black color of skin, 26 Black lead, 370 Black widow spider, 540 Bladan, 375 Bladder, inflammation of, 80 spasms of, 80 tumors of, 80 Blepharitis, 104 Blepharospasm, 105 Blighia sapida, 264 Blindness, 113 Blister beede, 277 Blood, bile pigments in, 126 cholinesterase content, 129 coagulation time of, 125 color, 124 hypercalcemia, 128 hyperglycemia, 127 hyperpotassemia, 128 hypocalcemia, 128 hypoglycemia, 127 hypopotassemia, 129 increased uric acid, 128 INDEX Blood cells, fragility, 125 nucleated, 120 sedimentation rate, 125 Blood vessels, degenerative changes, 60 Blowfish, 565 Blueberry, 588 Blue halos around light, 115 Bolus alba, 396 Bone changes, 38 Boric acid, 264 determination, 145 Borneol, 558 Bornylacetate, 558 Boron hydride, 265 Borothane, 265 Botete, 565 Botulism, 265 Bradycardia, 57 Brain, 84 Brass founder's fever, 27 ' Breath, odor of, 39 acetone, 40 fetid, 39 garlicky, 39 shortness of, 40 Brilliant violet, 234 Brimstone, 551 British Anti-Lewisite, 337 Broad bean, 362 Broke back, 329 Bromadal, 286 Bromates, 266 detection, 145 Bromides, 266 detection, 145 Bromine, 268 Bromoacedc acid methyl ester, 268 p-Bromoaniline, 473 <x-Bromo-(a-ethylbutyryl)-urea, 286 Bromoform, 269 3-Bromopropene-l, 219 Bromsulphalein, 551 Bronchial secretion, increase of, 50 Bronchial spasm, 43 treatment, 190 Bronchial stenosis, 51 Bronchiectasis, 51 Bronchiolids, 50 Bronchitis, 50 Brucine, 269 Buphane disticha, 269 Buphanine, 269 Burning bush, 361 Burning in mouth, 64 Burns of the skin, 36 Burnt lime, 405 Bursine, 302 Butacaine sulfate, 270 Butadiene, 270 Butalgin, 424 ST085321 7 Butamben picrate, 270 605 Butanaloxime, 271 Butanediol-1,4, 271 Butanol, 271 Butapyrin, 390 Butazolidinc, 490 Butea, 533 Butesin picrate, 270 Butethanol, 558 2-Buaxy-N-(2-diethylaminoethyl)cinchonin- amide hydrochloride, 328 Butter of arsenic, 243 Butter of zinc, 596 Buttercup, 520 Butyl acetate, 271 Butyl alcohol, 271 p-Butylaminobenzoyldiemethylamine-ethanol hydrochloride, 558 n-Butylcarbitolthiocyanate, 404 Butylhydroxycinchoninic acid diethylamino- ethylester, 328 Butyn, 270 n-Butyraldoxime, 271 "B" wood, 595 C-6, 375 Cachexia, 20 Cadmium, 272 determination, 146 Cadmium oxide, 272 Caffeine, 273 determination, 146 Cajeputol, 361 Calabar bean, 500 Calciferol, 592 Calcium chloride, 274 Calcium cyanamide, 274 Calcium gluconate, 275 Calcium hypochlorite, 292 Calcium oxide, 405 Calcium phosphate, quadribasic, 573 Calcium superphosphate, 275 Calomel, 275, 419 Calsol, 357 Caltha palustris, 276 Camomile, 558 Camphene, 558 Camphor, 276, 558 Canadine, 379 . Cancer of lungs, 53 of urinary bladder, 80 Cannabis sadva, 412 Cantharidin, 277 Cape aloe, 220 p-Carbamylamino-phenyl arsonic acid, 278 Carbarsone, 278 Carbazotate, 228 2 -Carbethoxythio-1 -methylglyoxaline, 278 Carbimazole, 278 Carbolic acid, 487 606 ST08532 I 8 INDEX Carbolineum, 315 Carbomethane, 397 Carbon dichloride, 559 Carbon dioxide, 278 Carbon disulfide, 279 determination, 147 Carbonic acid anhydride, 278 Carbon monoxide, 281 determination, 147 Carbon tetrachloride, 283 detection, 148 Carbonyl chloride, 494 Carborundum, 286 N-(7-Carboxytnethylmercapturi'0-methoxy) * propylcamphoramic acid disodium, 416 Carbromal, 286 Cardiac dilatation, acute, 59 Cardiazol, 278, 483 Cardol, 411 Carvone, 558 'v- - Casandne, 332 Castor bean, 286 Castrix, 287 Casts in urine, 130 Cataract, 111 Catatonia, 92 Catechu brown, 234 Cedar oil, 287 Cedral, 287 Cedrcne, 287 Centruroides sculpatorius, 529 Cephaelis ipecacuanha, 390 Cerbera thevetica, 464 Cevadilla seeds, 589 Cevadilline, 589 Cevadiae, 589 Cevine, 589 Chalcedony, 533 Cheilitis, 62 Chelidonium majus, 288 Chemical antidotes, 181 Chemosis, 104 Chenopodium, 288 Cherry mahogany, 409 Chestnut, 595 Cheyne-Stolces respiration, 43 Chili saltpeter, 454 China berry, 413 China clay, 396 Chinacrine, 516 , China oil, 484 China wood oil, 585 Chinese cinnamon, 305 Chinese tea, 273 Chinosol, 384 Chloral, 288 Chloral hydrate, 289 detection, 148 Chloralosane, 289 Chloralose, 289 determination, 148 Chloramine-T, 290 Chloramphenicol, 290 dcterminadon, 148 Chlorates, 291 detection, 149 Chlordane, 292 determination, 149 Chlorguanide hydrochloride, 296 determination, 149 Chlorinated lime, 292 Chlorine, 293 Chlorine dioxide, 294 Chlorine nitride, 459 Chlorine peroxide, 293 Chloroaminophenol, 372 Chloroacetic acid, 439 Chloroacetophenone, 294 Chloroaniline, 294 Chlorobenzene, 295 2-Chloro-buta-13-diene, 298 Chlorocaine, 511 Chlorodiamines, 372 2-Chloroethanol-l, 356 2-Chloro-10-(3 -dimethylaminopropyl) -pheno- thiazine hydrochloride, 299 2-Chloro-4-dimethyIamino-6-methylpyrimi- dine, 287 Chloro-dinitrobenzene, 295 N-(2-Chloroethyl)-dibenzyIamine, 328 Chloroform, 295 determination, 149 Chloroguanide hydrochloride, 296 determination, 149 Chloromycetin, 290 Chloronaphthalene, 297 p-Chloronitrobenzenc, 473 Chlorophenothane, 323 1 - (p-ChlorophenyI) -5-isopropylbiguanide, 296 Chloroprene monomer, 298 Chloropicrin, 298 2-Chloropropanc, 393 Chlorosalicylic acid anilide, 299 Chlorosulfonic acid, 299 Chlorothen citrate, determination, 139 u-Chlorotoluene, 261 5-Chloro-2-toluidine, 299 Chlorpromazine, 299 Chlortetracycline, 301 determination, 149 Chokecherry, 302 Choline, 302 Cholinesterase, determination, 150 Choline succinate dichloride dihydrate, 545 Choreiform movements, 96 Chromates, 302 determination, 150 Chromium trioxide, 302 INDEX Chrysanthemum cocdneum, 513 Chrysarobin, 304 Chrysiasis, 25 Chrysoidine, 347 Cicuta virosa, 304 Cicutoxin, 304 Cinchonine, 304 Cinchophen, 305 detection, 150 Cineol, 361 Cinnamene, 545 Cinnamol, 545 Cinnamon aldehyde, 305 Cinnamon oil, 305 Cinnamonium cassia, 305 Cinnamyl acetate, 305 Circulatory collapse, 56 treatment, 195 Citral, 404, 558 Citric add, 305 Citrullus colocynthis, 310 Claviceps purpura, 351 Cliradon, 398 Clorox, 306 Coagulation time, decrease of, 126 increase of, 125 Coal dust, 306 Coal oil, 390 Cobalt, 306 Cobalt acetate, 307 Cobaldne, 306 Cobra, 535 Cocaine, 307 detection, 150 Cocculine, 502 Coccuius indicus, 502 Coccus laca, 533 Cocobolo wood, 594 Codeine, 309 Coffee beans, 273 Cola nut, 273 Colchicine, 310 Colchicum autumnale, 310 Colic, 73 Collapse, circulatory, 56 Colocynth, 310 Color vision, disturbance of, 114 Coma, 88 treatment, 199 Compound 3953, 577 Compound 42, 593 Confusion, 89 Congo hardwood, 595 Coniine, 311 Conium maculaturn, 311 Conjunctiva, corrosion, 104 hemorrhages, 104 inflammation, 103 Conjunctivitis, 103 Conquinine, 517 ST 08532l9 Constipation, 74 Conteben, 471 Convulsions, 94 clonic, 94 tonic, 94 treatment, 198 Copper, 311 Copper acetoarsenite, 242 Copperhead snake, 535 Copper sulfate, 311 therapeutic use, 181 Coral snake, 535 Comcampion, 217 Corncockle, 217 Cornea, discoloration, 105 inflammation, 106 turbidity, 106 ulceration, 106 Corn rose, 217 Coronary thrombosis, 59 Corrosion of conjunctiva, 104 of skin, 36 of stomach, 70 of uterus, 83 of vagina, 83 Corrosive sublimate, 417 Corticotropin, 312 Cortigen, 313 Cortisone, 313 Cortisone acetate, 313 Cortone, 313 Coryza, 46 Cotimizin, 392 Cough, 44 treatment, 192 Couhage, 443 Coumadin sodium, 593 Cow cabbage, 374 Cowhage, 443 Cow-itch, 443 Cow-parsnip, 374 Cowslip, 276 Crab eyes, 205 Creolin, 314 Creosote, 314 Creosote bush, 595 Cresol, 315 "Crinex" wool, 564 Crisalbene, 369 Crocus sativus, 523 Crotonaldehyde, 316 Croton oil, 316 Croton tiglium, 316 Crow eyes, 543 Crow foot, 520 Cryolithosis, 364 Cryogenine, 532 Crystalluria, 133 Crystal violet, 234 Cubeb, 317 607 608 ST 0853220 INDEX Cubeba officinalis, 317 Curasao aloe, 220 Curare, 317 determination, 151 Curdn, 395 Cutting oil, 318 Cyanamide, 124, 274 Cyanides, 318 detection, 151 Cyanoethylene, 216 Cyanogen chloride, 320 Cyanomethane, 212 Cyanosis, 23 Cyclohexylamine, 320 a-Cydohexyl-a-phenyl-1 -piperidinepropanol hydrochloride, 274 Cydotrimethylenetrinitramine, 320 Cyclopropane, 320 Cyclorite, 320 C. I Ol&YV'` * Cycrimine hydrochloriiM) 321 d-Cymene, 288 Cytisine, 321 Cytisus laburnum, 321, 378 Daffodil, 448 Dalmatian insect powder, 513 Daniione, 486 Daphne mezereum, 322 Darnel, 407 Datura stramonium, 249, 322, 384, 528 Daturine, 384 DDT, 323 determination, 152 Deadly amanita, 223 Deafness, 115 Death camass, 599 Death fish, 565 Decamethonium iodide, 324 Decamethylene-bis-(trimethylamine-ammo nium iodide), 324 Decicaine, 558 Decubitus, 36 Deerwort, 362 Dehydradon, 21, 72 Delirium, 89 Ddphinium staphisagria, 324 Delta Cortef, 509 Deltasone, 509 Deltra, 509 Dementia, 92 Demerol, 414 Dermatitis, exfoliative, 33 medicamentosa, 29 venenata, 28 Dermato-polyneuritis, 34 Derrid, 325 Derris eliptica, 325 Desmodur-T, 577 d-Desoxyephedrine, 424 r-Desoxynorephedrine, 228, 424 Desoxyfed, 424 Desoxyn, 424 Devil's apple, 322 Dexedrine sulfate, 325 Dexoval, 424 a-Dextrochloralose, 289 Dextrocymene, 288 DFP, 336 Diacetylmorphine, 374 Didakene, 559 Dialkylphosphate, 325 Diamidogen sulfate, 379 Diamine sulfate, 379 3,3'-Diamino-4,4'-dihydroxyarsenobenzene, 245 p-Diaminodiphenyl, 261 4.4- Diaminodiphenyl sulfone, 326 determination, 152 1.2- Diaminoethane, 356 Diaminon hydrochloride, 424 Diamino-phenols, 372 2.4- Diamino-1-toluene, 576 Diamox, 210 Diamthazole dihydrochloride, 248 Diatomaceous earth, 326 Diaphoresis, 21 Diaphoretics, therapeutic use, 188 Diarrhea, 21,71 treatment, 196 Diazomethane, 327 Dibenamine hydrochloride, 328 Dibenzothiazine, 489 Dibcnzyl-0-chlorethylamine hydrochloride, 328 Dibenzyline, 328 Diborane, 265 Dihorohexahydride, 265 1.2- Dibromoethane, 328 3-DibromopropeneT, 219 2,7-Dibromo-4-hydroxymercuric fluorescein di sodium, 422 Dibucaine hydrochloride, 328 determination, 152 Dichapclatum cymosum, 538 Dichapelatum toxicarium, 329 Dichloren, 458 Dichloroether, 330 Dichlorobenzene, 329 Dichlorodiethyl ether, 330 Dichlorodiethylsulfide, 444 Dichlorodinitrobenzene, 330 Dichlorodiphenyltrichloroethane, 323 Dichloroethane, 330 Dichlorohydrin, 330 Dichloroisopropyl alcohol, 330 Dichloromethane, 433 2.2- Dichloro-methyldiethylamine hydrochlo ride, 458 INDEX STOS53221 609 Dichlorophene, 331 2.2- Di-(p-cblorophenyl)-acetic add, determi nation, 152 Dichlorophcnylamne, 492 Dicodid, 335 Dicoumarin, 331 Dicoumarol, 331 Dicumarol, 331 determination, 152 Didakene, 559 Didromycin, 336 Didroxane, 331 Dieftenbachia seguina, 332 Diethazine, 332 Diethylamine acetarsol, 333 Diethylaminoacetarsone, 333 6-(/9-DiethyIaminoethoxy) -2-dimethylamino- benzathiazole dihydrochloride, 248 Diethylaminoethyl -p-aminobenzoatejrydrochlo- ride, 511 Diethylaminoethylamino-4-methylthioxan- thone, 407 N-Diethylaminoisopentyl-8-amino-6-methoxyquinoline, 504 10-{2-Diethylaminoethyl)-phenothiazine, 323 Die thylaminoethyl-9-xanthene-carboxylate methobromide, 427 Diethyl-/9-ch!oroethylamine, 333 3.3- Diethyl-2,4-dioxo-5-methylpiperidine, 438 3.3- Diethyl-2,4-dioxo-piperidine, 438, 513 Diethyl-dithiocarbamate, 207 Diethylenediamine, 503 Diethylene ether, 333 Diethylene glycol, 333 Diethylene oxide, 343 0,0-Diethyl-0-(p-nitrophenyl)-monothiophos- phate, 477 Diethyloxide, 352 Diethylphosphate, 325 Diethylsulfone-dimethyl-methane, 551 Digitalis, 334 Digitalis purpura, 334, 378 Dihydan soluble, 344 Dihydrocodeinone, 335 Dihydrocodeinone cnolacetate, 207 Dihydromorphinone, 335 Dihydromycine, 336 2.3- Dihydro-3 -oxo-benzisosulfonazole, 523 Dihydrostreptomycin, 336 Dihydroxy-arsenobenzene-methanolsulfoxylate, 245 m-Dihydroxybenzene, 521 0- Dihydroxybenzene, determination, 168 p-Dihydroxybenzene, 383 1.4- Dihydroxybutane, 271 1 - ( 3,4 -Dihydroxyphenyl) -2 -isopropylamino- ethanol, 394 1- l-(3,4-Dihydroxyphenyl)-2-methylaminoethanol, 350 Dihydroxysucdnic add, 556 Di-isopropyl-duorophosphatc, 336 Di-isopropylpho<phate, 325 Dilantin sodium, 344 detection, 153 Dilaudid, 335 Dillantin, 344 Dimcnhydrinate, 337 Dimercaprol, 337 2.3- Dimercaptopropanol, 337 determination, 53 therapeutic use, 188 4-Dimethylaminoantipyrine, 225 Dimethylaminoazobenzene, 347 dl -6-Dimethylamino-4,4 -diphenyl-3 -heptanone hydrochloride, 424 2 - [ a-(Dimethylaminoethyl) benzyl ] -pyridine, 512 2 - [ (2-Dimethylaminoethyl) - (p-methoxyben- zyl)-amino]-pyridine, 515 2 - [ (2 -Dimethylaminoethyl) -2-thenylamino] - pyridine hydrochloride, 427 4-Dimethy!aminol,4,4a,5,5a,6,ll,12a-octahy- dro-3,5,6,12,12a-hexahydroxy-6-methyl-1,1, 1-dioxo-naphthacene carboxamide, 469 10-(8-Dimethylaminopropy[)-2-chlorophenothiazine hydrochloride, 299 Dimethylaniline, 338 Dimethylazobenzene, 347 Dimcthylbenzene, 595 Dimethylcarbinol, 393 Dimethyldithiocarbamate, 207 N- (3,4 -Dimethyl-5 -boxazol yl) -sulfanilamide, 550 Dimethylketone, 211 Dimethylnitrosamine, 338 Dimethylphthalate, 339 Dimethylphosphate, 325 Dirpethylsulfate, 339 3.7- Dimethyl -9- (2,6,6-trimethyl -1 -cyclohexenl-yl)-2,4,6,8-tetraen-l-ol, 590 0,0-Dimethyl-S-(l,2-dicarbethoxyethyl)-dithionophosphate, 410 3.7- DimethyIxanthine, 567 Dinacrin, 392 Dinitrobenzene, 340 detection, 153 2.4- Dinitro-l-chlorobenzene, 341 Dinitrocresol, 341 3.5- Dinitro-2-hydroxy-l-methylbenzene, 34! 2.4- Dinitrophenol, 341 detection, 154 Dinitrotoluene, 342 Diodrast, 389 determination, 157 Dionine, 359 Dioxane, 343 3.5- Dioxo-1,2 -diphenyl - 4 -butyl -pyrazolidine, 490 610 ST0853222 INDEX Diparcol, 332 Diphenhydramine hydrochloride, 343 determination, 153 Diphenyl black baie, 347 Diphenylhydantoin sodium, 344 Diphenylthiourea, 207 Diplopia, 113 Dipyrone, 434 Direct blue, 234 Disodium 3,3'-diamino-4,4''dihydroxy-arseno- benzene-N-dimethylencsulfonate, 549 Disodium phenoltecrabromophthalein sulfonate, 551 Disodium succinate, 545 Disorientation, 89 Dispadol, 414 Dispcrmin, 503 Disulfiram, 345 determination, 154 Dithiopropanol, 337 Di-o-tolylethylenediamine, 207 Di-o-tolyl-thiourea, 207 Ditubin, 392 Diuretics, therapeutic use, 186 Diuretin, 567 Divinyl ether, 346 Divinyl oxide, 346 Dog parsley, 346 Dolantal, 414 Dolantin, 414 Dolophin hydrochloride, 224 Dolosal, 414 Dolvanol, 414 Dormiral, 486 Dormison, 435 Double vision, 113 Dramamine, 337 Drinalfa, 424 Drinupal hydrochloride, 296 Drisdol, 592 Dromoran, 429 Duboisia leichhardii, 384 Dulcamara solanum, 346 Dulcin, 347 Dumb cane, 332 Durathion, 477 Dwarf bay, 322 Dyes, 347 Dymarsan, 209 Dysmenorrhea, 82 , Dyspnea, 41 Eak, ringing of, 115 Eau d'Arquebuse, 524 Ecchymoses, 35 Edathamil, 357 Edema, pulmonary, 51 EDTA, 357 Efocaine, 347 Efroxine, 424 Egg white as antidote, 183 Ehrlich 594, 209 Elastonon, 229 Electrolyte balance, 193 Elephant's scratch wort, 443 Elm, 595 Emery, 286 Emetics, therapeutic use, 180 Emetine, 348 determination, 154 Emotional status, 22 Encephalitis, 92 Endocladium temulatum, 407 Endolat, 414 Endrin, 348 English yew, 556 Enhydrina schistosa, 536 Eosin, 349 Eosinophilia, 120 Epanutin,344 Ephedrine, 349 Epicauta cinerea, 277 Epinephrine, 349 determination, 154 Epithelioma, 36 Epsom salt, 409 Eptoin, 344 Equanil, 415 Erections, 82 Erethism, 85 Ergot, 351 Ergotamine tartrate, 351 determination, 155 Eructions, 70, 71 Erythema, 30 Erythema nodosum, 31 Erythredema, 34 Erythrosin, 347 Erytroxylon coca, 307 Erythrityl tetranitrate, 352 Eserine, 500 Esophagus, corrosion of, 69 irritation of, 69 paralysis of, 69 strictures of, 21 Esperal, 345 Estimulex, 428 Estopen, 480 Etamon chloride, 560 1,2-Ethanediol, 357 Ethanenitrile, 212 Ethanethiol, 416 Ethanite, 570 Ethanol, 352 detection, 155 Ethanon chloride, 560 Ethene, 355 Ethenyl trichloride, 579 Ether, 354 determination, 155 INDEX 611 Ethereal sulfate in urine, 133 J Ethenone, 397 Ethenyl trichloride, 579 Ethine, 213 Ethocaine, 511 Ethozyacetanilide, 212 Ethyl acetate, 354 Ethyl alcohol, 352 Ethyl bromide, 355 Ethylcarbamate, 587 Ethyl chloride, 355 5-EthyI-dihydro-5-phenyl,4,6,(lH,5H)pyrimidine-dione, 510 Ethylene, 355 Ethylene bromide, 328 Ethylene chlorhydrin, 356 Ethylene chloride, 330 Ethylene diamine, 356 Ethylene diamine tetraacetate, 357 Ethylene glycol, 357 v Ethylene glycol dinitrate, 358 Ethylene glycol monomcthylether acetate, 431 Ethylene oxide, 358 Ethylene tetrachloride, 559 Ethylene trichloride, 579 Ethyl ether, 352 Ethylhydrocuprein, 359 Ethyl iodide, 359 Ethylmercaptan, 416 Ethylmercury chloride, 219 Ethylmercury phosphate, 219 5-Ethyl-5-(methylbutyl)-thiobarbiturate so dium, 571 5-Echyl-3-methyl-5-pbenylhydantoin, 435 Ethylmorphine hydrochloride, 359 Ethyl nitrite, 360 5-Ethyl-5-phenylbarbituric add, 486 Ethyl tctraphosphate, 562 Ethylurethan, 587 Eucaine, 360 Eucalyptol, 361, 558 Eucalyptyus globulus, 361, 558 Eucodal, 335 Eugenol, 305 Euonymin, 361 Euonymus atropurpura, 361 Euonymus europaeus, 361 Eupatorium urdcaefotium, 362 Euphoria, 92 Eurenyl, 486 Euscorbius europaeus, 529 Excitadon, 22 Excitement, 84 Exfoliadve dermadds, 33 Exophthalmos, 109 Extrasystoles, 57 Eyeball, abnormal posidon, 109 destrucdon, 112 Eyeground, congesdon, 111 Eyelids, ptosis, 105 Facial expression, 22 Fagin, 302 Fagus silvatica, 257 Fainting, 55 False grape, 479 False morel, 373 False white cedar, 574 Fatigue, 87 Fear, 22, 86 Feer's disease, 34 Fenchone, 558, 574 Fennel, 558 Ferric chloride, 363 Ferrous sulfate, 391 Fetus, injury of, 83 Fever, 21, 26 treatment, 198 Ficus, 533 Filix mas, 248 Finger cherry, 363 Finger nails, discoloradon, 37 inflammation, 37 malformation, 37 Five-leafed ivy, 479 Flickering, 112 Flint, 533 Floropryl, 336 Flowers of zinc, 597 Fluorides, 363 determination, 155 Fluoroacedc acid, 538 determination, 158 Flushing, 22 Fly agaric, 222 Formaldehyde, 365 detection, 156 Formalin, 365 Formic acid, 365 Formic acid methyl ester, 433 Formonitrile, 380 p-Formylacetaldehyde thiosemicarbazone, 471 Fourneau 190, 209 Foxglove, 334 Fragility of red blood cells, 125 French chalk, 555 Friar's cowl, 215 Fuadine, 234 Fuchsin acid, 347 Fucomarin, 374 Pugu, 443 Fuller's earth as adsorbent, 184 Fumagillin, 365 Furacin, 458 Furadantoin, 457 2-Furanaldehyde, 366 Furfural, 366 Furon, 463 G-4, 331 612 ST 0853224 INDEX Galerina venenata, 366 Gallotannic acid, 556 Gallotannin, 556 Gamboge, 371 Gammexane, 259 Gantrisin, 550 Gantrosan, 550 Garantose, 523 Garcinia morella, 371 Gardenal, 486 Garget, 500 Garlic, 219 Gasoline, 366 Gastric lavage, 183 Gastric hemorrhages, 70 Gastritis, 69 Gelsemine, 368 Gelsemium scmpervirens, 368, 378 Gemalgene, 579 Geraniol, 558 Germalgene, 579 Germanin, 554 Gesarol, 323 Gexane, 259 Gifblaar, 538 Gingiva, discoloration, 64 hypertrophy, 65 Gingivitis, 65 Glass, 533 Glaucoma, 112 Glossitis, 66 Glosso-Sterandryl, 437 Glottis, corrosion, 49 edema, 48 treatment, 190 Glucide, 523 Glucochloral, 289 a-D-Glucochloralose, 289 Gluside, 523 Glutamic acid, 368 Glycemia, 127 Glycol, 357 Glycosuria, 131 Goa powder, 289 Gold, 369 determination, 156 Golden celadine, 288 Golden seal, 379 Gold sodium thiosulfate, 369 Gossypine, 302 Goyl, 209 Grain dust, 370 Granuloma, 36 Graphite, 370 Green hellebore, 590 Green vetch, 399 Green vitriol,. 391 Groundsel, 532 Guaiacol, 371 Guanatol hydrochloride, 296 Guanidines, 207 Guarana paste, 273 Gum arabic, 206 Gum Gut'tae, 371 Gymnothorax flavimarginatus, 371 Gynecomastia, 82 Gyremytra esculenta, 373 Habu snake, 535 Hair, discoloration, 37 dyes, 372 loss, 37 Halazone, 476 Hallucinations, 90 Halos, blue, 115 Halowax, 297 Haselwurz, 247 Headache, 84 frontal, 48, 84 Hearing, impaired, 15 increased, 116 Heart, hypertrophy, 59 Heart muscle, injury, 58 Hedeoma pulegoides, 482 Hedulin, 486 Heinz bodies, 120 Helleborein, 372 Helleborin, 372 Helleborus nigcr, 372 Helleborus viridis, 372 Hell oil, 397 Helvella esculenta, 373 Hematuria, 130 Hemlock, 311 Hemoglobinuria, 130 Hemorrhages, 35 conjunctival, 104 retinal, 111 Henna, 372 Heparin, 373 Hepatitis, toxic, 75 treatment, 196 Heradeum tana turn, 374 Heroin, 374 Herpes zoster, 34 Hexabione, 515. 1,23,4,5,6-HexachIorocydohexane, 259 l,2,3,4,10,10-Hexachloro-l,4,4a,5,8,8a-hexahy- dro-dimethano-naphthalene, 217 Hexachloronaphthalene, 297 Hexaethyltetraphosphate, 375 Hexagene, 320 Hexahydropyrazine, 503 Hexahydrothymol, 413 Hexamethonium bromide, 375 Hexamethylencdiamine, 376 Hexamethylenetetramine, 428 Hexamine, 428 Hexanitrodiphenylamine, 376 Hexanitrodiphenylamine, ammonium salt, 376 INDEX ST 0 8 53225 Hexasodium sym-bis*(m-anunobenzoyt-mamino-p-methylbenzoyl- i -naphthylamino4,6,8-trisulfonate) -carbamide, 554 Hexylresorcinol, 376 Hippomane mancinella, 376 Hirsutism, 38 Histadyl, 235, 427 Histamine, 377 Hoarseness, 49 Hoechst 10820, 424 Homatropine, 397 Honey, 377 Horse chestnut, 527 Hueva vegetal, 264 Hunger, 61 Hyamine, 260 Hydantal, 344 Hydelta, 509 Hydralazine hydrochloride, 378 ... .... Hydrastine, 379 Hydrastinine, 379 Hydrastis canadiensis, 379 Hydrazine sulfate, 379 1- Hydrazinophthalazine hydrochloride, 378 Hydrazoic acid, 379 Hydrochloric acid, 380 Hydrocyanic acid, 318, 380 Hydrofluoric acid, 381 Hydrogen phosphide, 494 Hydrogen selenide, 382 Hydrogen sulfide, 382 Hydroquinone, 383 detection, 156 Hydrostrychnic acid hydrochloride, 442 o-Hydroxy-4-aminobenzoic acid, 472 Hydroxybenzamide, 524 Hydroxybenzene, 487 o-Hydrorybenzoic acid, 525 17-Hydroxy-11-dehydrocortisone, 313 (/3-Hydroxyethyl)-trimethylammonium hy droxide, 302 3-Hydroxy-N-methylmorphinan, 429 5-Hydroxy-6-methyl -3,4 -pyridine-dimethanol hydrochloride, 515 a-Hydroxyphcnylacetic acid, 410 4 - (m-Hydroxyphenyl) -1 -methyl-piperidyl- ethylketone, 398 3-Hydroxyphenyl-trimethyIammonium-methylsuifate dimethyl carbamic acid ester, 449 3-Hydroxyphenyl-trimethylammonium-bromide dimethylcarbamic acid ester, 449 2- Hydroxy- 1,2,3-propane tricarboxylic acid, 305 ct-Hydroxypropionic acid, 398 8-Hydroxyquinoline sulfate, 384 m-Hydroxythiophenol. 571 Hyoscine, 528 Hyoscyamine, 386 Hyoscyamus niger, 249, 384, 528 Hypercalcemia, 128 Hyperglycemia, 127 Hyperosmia, 48 Hyperpotassemia, 128 Hypertension, 60 Hyperthermia, 27 treatment, 198 Hyperthyroidism, 83 Hypocalcemia, 128 Hypodermodysis, 186 Hypoglycemia, 127 Hypoglycin A, 264 Hypoglycin B, 264 Hypopotassemia, 129 Hypotension, 60 Hypothermia, 27 treatment, 198 Hypothyroidism, 83 Hypoxia, 40 Icterus, 75 /9-Imidazole-4-ethylamine, 377 Indian arrow tree, 361 Indian balsam, 484 Indigo, 384 Indophenol reaction, 136 Inebriation, 86 Infusorial earth, 326 INH, 392 Inhiston, 512 Ink berry, 500 Insomnia, 85 Insulin, 385 Intocostrin, 317 Intraocular pressure, decrease, 111 increase, 112 Intravenous infusion, 186 Intraval sodium, 571 Inversine hydrochloride, 412 Iodates, 385 Iodeikon, 564 Iodides, 386 Iodine, 387 as antidote 182 detection, 157 Iodine compounds, 387 Iodoethane, 359 Iodoform, 389 Iodomethane, 433 Iodophene, 424, 564 Iodophthalein, 564 lodopyracet, 389 determination, 157 Iodoxyl, 388 "Ipe" wood, 594 Ipecac, 390 as emetic, 181 Iproniazid, 390 Irgapyrin, 390 Iris florentina, 465 Iritis, 110 Irococaine, 511 613 614 Iron, 391 Iron perchloride, 363 Iron sulfate, 391 Iron trichloride, 363 Iron vitriol, 391 Irritability, 85 Isoamylacctate, 230 Isoamyl alcohol, 231 Iso-amyne, 228 Isoflurophate, 336 Isoniazid, 392 Isonicodnic add hydrazide, 392 l-Isonicotinyl-2-isopropylhydrazine, 390 Isonorin, 394 Isophen, 424 Isopimpinellin, 374 Isopropyl alcohol, 393 Isopropyiarterenol, 394 Isopropyl chloride, 393 Iso-safrole, 394 *- Isuprel hydrochloride, 394 Ivray, 407 Jamestown weed, 322 Japanese lacquer tree, 505 Jatropha curcas, 395 Jatropha ureus, 395 Jaundice, 75 fequirity beans, 205 Jet beads, 522 Jimson weed, 322 Jug fish, 565 Jumbo beans, 205 Juniper virginiana, 287 Jute, 396 Juvocaine, 511 Kalmia augusdfolia, 378 Kalmia cuneata, 378 Kalmia latifolia, 378 Kaolin, 396 Karophen, 209 Katatonia, 92 Keratitis, 106 Keratoses, 34 Kerocaine, 511 Kerosene, 396 Ketene, 397 Ketobemidone, 398 Ketonuria, 131 Kidney, injury to, 77 Kieselguhr, 326, 533 Kornrade, 217 Korsakow syndrome, 91 Koryfen, 414 Kryogenin, 532 Kussmaul respiration, 43 r Lacca, 533 Lacrimadon, 103 INDEX Lactarius vellereus, 398 Lactic add, 398 Lapis lazuli, 587 Largacdl, 299 Laryngitis, 49 Laryngospasm, 49 Larynx, edema, 49 Lassitude, 87 Lathyrus sadva, 399 Latrodectus mactans, 540 Laurel oil, 399 Lauron, 369 Lawry's seasoned salt, 369 Lead, 399 detection, 157 in hair dyes, 372 Lead acetate, 399 Lead arsenate, 403 Lead arsenite, 404 Lead line, 64 Lemon grass oil, 404 Lethane, 368 Leucine crystals in urine, 133 Leukocytosis, 121 Leukopenia, 122 treatment, 200 Levo-glutamic acid, 368 Levo-Iimonene, 288 Libido, decreased, 82 increased, 82 Ligustrum vulgare, 404 Limarsol, 209 Limbs, abnormal position, 38 Lime, 405 Lime water, as antidote, 182 Limonene, 558 Linalenol, 558 Lindane, 259 Lips, edema, 63 inflammation, 63 Lithium chloride, 405 Livazone, 471 Liver, cirrhosis, 76 fatty degeneration, 76 inflammation, 75 yellow atrophy, 76 Lividity, 23 Lixivium, 407 Lobelia inflata, 406 Lobeline, 406 Loco disease, 530 Lolium temulatum, 407 Lophophora williamsii, 423 Lorchel, 373 Lucathone hydrochloride, 407 Luminal, 486 Lungs, cancer of, 53 gangrene of, 53 Luridine, 302 Lye, 407 INDEX Lymphocytosis, 122 Lysol, 315 Lystenon, 545 Lytta vesicau, 277 Macassai oil, 524 Maculo-papular eruptions, 31 Magnesium, 409 Magnesium-caldum silicate, 247 Magnesium oxide, 409 aj antidote, 182 I, I i Magnesium silicate, 555 Magnesium sulfate, as antidote, 182 i Magnifera indica, 411 Ma Huang, 349 Majonia pubescent, 378 Makare, 409 Maki-maki, 565 Malachite green, 234, 347 Malagride, 209 j? Malathion, 410 Male fern, 248 3 Maleic acid anhydride, 410 Malonylurea, 251 Manchineel, 376 Mancellier, 376 Mancinellbaum, 376 Mandelic acid, 410 Mandelonitrile-/3-genriobioside, 230 Mandrake root, 505 Manganese, 411 Manganese dioxide, 411 Mango, 411 Mansonia, 594 Manzinello, 376 Maple, 595 Mapharscn, 469 Marcazole, 428 Marihuana, 412 Marsh marigold, 276 Marsilid, 380 Mardus yellow, 347 Mask-like face, 22 Master wort, 374 Mate tea, 273 Maxiton, 228 May apple, 505 Meadow saffron, 523 Mecamylamine hydrochloride, 412 Mechlorethamine hydrochloride, 458 Mecodrin, 228 Medicago sadva, 218 Melia azedarach, 413 Melianthus major, 378 Melitoxin, 331 Memory, loss of, 88 Menorrhages, 62 Mental deterioration, 92 Menthol, 413, 558 Mepacrine, 516 Meperidine hydrochloride, 414 Meprobamate, 415 Mepyramine base, 515 Merbromin, 422 Mercaptan, 416 Mercaptoacede acid, 570 Mercaptobcnzothiazole, 207 2-Mercapto-4-hydroxypirimidine, 572 Mercaptomerin sodium, 416 m-Mercaptophenol, 571 Mercupurin, 416 Mercurialends, 421 Mercuric chloride, 417 Mercurochrome, 422 Mercurophilline, 416 Mercurous chloride, 275, 419 Mercurozanthin, 416 Mercury, 420 antisepucs, 422 detection, 158 diuredcs, 416 Mercury fulminate, 422 Mercury oxycyanide, 422 Mersalyl, 416 Merthiolate, 422 Mesantoin, 435 Mescal buttons, 423 Mescaline, 423 Mesothorium, 574 Mesquite, 595 Metacortandracin, 509 Metacortandralone, 509 Metafuel, 423 Metahydroxybcnzene, 521 Metaldehyde, 423 Metal-fume fever, 27 Metal line, 64 Metandren, 437 Metanil yellow, 347 Metaphen, 422 Meta-phenylenediamine, 207 Meta-toluenediamine, 207 2-Meta-toluidine, 207 Metcorism, 73 Methadone, 424 determinadon, 158 Methamphetamine hydrochloride, 424 Methanal, 365 Methandiene bromide, 427 Methane, 425 Methanol, 425 determination, 158 Methanthiiene bromide, 427 Methapyrilene, 427 determination, 139 Methedrine, 424 Methemoglobinemia, 124 treatment, 201 Methemoglobinuria, 131 Methenamine, 428 615 616 ST 0853228 INDEX Methimazole, 428 Methiocil, 438 Methorphinan hydrobromide, 429 Methoxyphenol, 371 Methyl acetate, 429 jJ-Methylacrolein, 316 Methyl alcohol, 425 Methylallene, 270 2- (2-Methylaminoethyl)-2-thenylaminopyridine hydrochloride, 427 3 -Methylamino-isocamphane hydrochloride, 412 6-Methylamino-2-methylheptene, 463 0- Methylaminophenol, 465 p-Methylaminophenol sulfate, 439 Methylamphetamine, 424 Methylaniline, 207, 479 Methylbenzene, 576 Methyl-benzoyl-ecgonijK, 307 Methyl-bis-(/S-chloroetHyI)-amine hydrochlo ride, 458 Methyl bromide, 429 Methyl chloride, 431 Methyl cellosolve, 431 Methyl cyanide, 212 Methyl-dodecylbenzyl-trimethylammonium chloride, 260 2,2'-Methylene-bis-(4-chlorophenol), 331 3,3'-Methylenc-bis-(4-hydroxycoumarin), 331 Methylene blue, 234, 432 Methylene chloride, 330 Methylene-dianilide, 207 Methylene dichloride, 433 1,2 -Methylenedioxy-4 -propenylbenzene, 394 Methyl formate, 433 Methyl'hydantoin, 435 Methyl iodide, 433 Methylisomyn, 424 5-Methyl-2-isopropylphenol, 575 Methylmelubrin, 434 1- Methyl-2-mercaptoimidazolc, 428 Methylmercury chloride, 219 Methylmercury iodide, 219 Methylmethacrylate, 434 Methylmorphine, 309 N-Methyl-N-nitroso-N'-guanidine, 434 Methylparafynol, 435 Methylpentynol, 435 dl-a-Methylphenethylamine, 207 Methylphenol, 315 N-Methyl-4-phenyl-4-carbethoxypiperidine hy drochloride, 414 Methyl-p-phenylenediamine, 207 Methyl-phenyl-ethyl hydantoin, 435 3- Methyl-5-phenylhydantoin, 435, 436 2- Methyl-4-phenyl-2,3,4,9-tetrahydropyrindene acid tartrate, 485 Methylpicrate, 581 rac/y- (2-Methylpipcridyl) -propylbenzoate hy drochloride, 503 2 -Methyl-2-n-propyl -1,3-propanediol mate, 415 Methylrosaniline chloride, 436 Methylsalicylate, 437 Methylselenide, 531 Methyltestosterone, 437 Methylthione chloride, 432 Methylthiouracil, 438 determination, 158 Methyltoluidine, 207 Methylviolet, 436 Methyl yellow, 347 Methyprylon, 438 Meticortanodrazin, 509 Meticortilone, 509 Meticorton, 509 Metol, 439 Metrazol, 483 determination, 163 Metycain, 503 Mezerinic acid anhydride, 322 Miadone, 424 Mild mercuric chloride, 419 Milk as antidote, 183 Milkman's syndrome, 39 Milk sickness, 362 Miltown, 415 Mimusops heckelii, 409 Mineral carbon, 370 Mint, 558 Miosis, 107 Mipafox, 439 Miracil D, 407 Mitral valve, injury, 59 Moccasin snake, 535 Monk's hood, 215 Monobromoethane, 429 Monobromomethane, 355 Monocalcium phosphate, 275 Monochloroa'cetic acid, 439 Monochlorobenzene, 295 Monochloroethane, 355 Monochloromethane, 431 Monofluoroacetic acid, 158 Monohydroxythiophenol, 571 Monoidomethane, 433 a-Monothioglycerol, 570 Moranyl, 554 Morbilliform eruptions, 31 Morel, 373 Morphine, 448 detection, 159 Mother of pearl, 442 Mountain laurel, 378 Mouse bane, 215 Mouth, dryness of, 67 Movellan, 442 Mucuna pruriens, 443 Mucanoin, 443 Muracil, 438 dicarba INDEX ST085322S 617 Muscarine, 222 Muscle, atrophy, 38 contractions, 98 spasms, 98 twitchings, 96 weakness, 103 Musquash root, 304 Mussel, 443 Mustard gas, 444 Mustard water as emetic, 181 Mustargen, 458 Musdne, 458 Myalgia, 101 Mycifradin sulfate, 448 Myciguent, 448 Mydriasis, 107 Myocrysine, 363 Myristicin, 445 Mysoline, 510 Mytilus californianus, 443 Mytilus edulis, 443 Myvizone, 471 * Nacanol, 554 Nail bed, inflammation, 37 Nail polish, 445 Nails, discoloration, 37 malformation, 37 Naphazoline hydrochloride, 446 Naphthalene, 446 detection, 160 Naphthol, 447 detection, 160 a-Naphthol orange, 465 Naphthol yellow, 347 detection, 160 a-Naphthylamine, 447 /3-Naphthylamine, 447 detection, 161 2-(1 -Naphthylmethyl)-imidazoline ride, 446 l-(l-Naphthyl)-2-thiourea, 220 Naphthuride sodium, 554 Narcissus comparabilis, 448 Narcissus poeticus, 448 Narcissus pseudopoecicus, 448 Narcylene, 213 Nausea, 61 and vomiting, treatment, 195 Neoantergan, 235, 515 Neoarsphenamine, 245, 448 detection, 161 Neocaine, 511 Neocid, 323 Neodonal sodium, 571 Neohetramine, 235 Neo Hombreol-M, 437 Neomcrcazole, 278 Neomycin, 448 Neo-penil, 480 hydrochlo Neosalvarsan, 245, 448 Neostigmine bromide, 449 Neostigmine methylsulfate, 449 Neoteben, 392 Neothesine, 503 Nephritis, 77 treatment, 197 Nephrosis, 77 Neptal, 416 Nerium oleander, 378, 464 Nerve gas, 450 Nervousness, 85 Nesdonal sodium, 571 Neuraltin, 476 Neuritis, 101 optic. 111 retrobulbar, 111 Neurobarb, 486 Neustab, 471 Niadrin, 392 Niacin, 451 Nickel, 451 Nickel carbonyl, 452 Niconyl, 392 Nicotiana tabacum, 452 Nicotine, 452 determination, 161 Nicotinic acid, 451 Nicozide, 392 Nidrazid, 392 Nifos, 562 Night blue, 234 Night shade, 539 Niperyt, 483 Niran, 477 Nitrates, 454 Nitric acid, 454 Nitrites, 455 detection, 161 p-Nitro-aniline red, 347 Nitrobenzene, 455 detection, 162 Nitrochlorobenzene, 457 Nitroerythrite, 352 5-Nitro-2-furaldehyde semicarbazone, 458 Nitrofurantoin, 457 N- (5-Nitro-2-furfurylidene) -1 -aminohydan- toin, 457 Nitrofurazone, 458 Nitrogen, 458 Nitrogen chloride, 459 Nitrogen dioxide, 461 Nitrogen monoxide, 463 Nitrogen mustard, 458 Nitrogen tetroxide, 461 Nitrogen trichloride, 459 Nitroglycerol, 459 4-Nitro-3-hydroxymcrcuri-o-cresol anhydride, 422 Nitromersal, 422 618 ST035323C INDEX Nitromethylurethane, 461 Nitronaphthalene, 460 Nitropenta, 483 Nitroprusside, 461 Nitroso-dimethylamine, 338 2-Nitroso-dimethylaniline, 207 Nitroso-methylurethan, 460 Nitrous fumes, 461 Nitrous oxide, 463 Noludar, 438 Norephedrine, 228 Norisodrine, 394 Norodinehydrochloride, 424 Nose, bleeding, 47 dryness, 47 hypertrophy of mucous membrane, 47 increased secretion, 47 irritation, 46 septum perforation, (47 ulceration, 47 Nosophene, 564 Novaldin, 434 Novocaine, 511 Noxal, 345 Nucleated red blood cells, 120 Nuclon, 471 Numoquin, 359 Nunol, 486 Nupcrcaine, 328 Nutmeg, 445 Nuvarone, 436 Nux vomica, 543 Nyetal, 286 Nydrazide, 392 Nylon, 463 Nystagmus, 110 Oak, 595 Occupational history, 17 Occupational poisoning, 5 Octalene, 217 Octin, 463 1,2,4,5,6,7,8,8-Octoch loro-2,3,3a,4,7,7a-hexahy- dro-4,7-methanoindcne, 292 Oculomotor cramps, 109 Oculomotor impairment, 109 Odor of breath, 39 Oil of cassia, 305 Oil of chenopodium, 288 Oil of mirbane, 455 Oil of sassafras, 524 Oil of sweet birch, 437 Oil of teaberry, 437 Oil of turpentine, 586 Oil of vitriol, 553 Oil of wintergreen, 437 Oleander, 464 Oleum infemale, 395 Oliguria, 79 w-chlorotoluene, 261 Opal, 533 Opisthotonus, 96 Opium, 464 Oppression in chest, 45 Optic atrophy, 111 Optic neuritis, 111 Optoquine, 359 Oral cavity, discoloration, 64, 65 irritation, 64 Oralcid, 209 Orange I, 465 Orange II, 347 Orarsan, 209 Oreton-M, 437 Orris, 465 Ortcdrine, 229 Orthodichlorobenzene, 329 2-Orthotoluidine, 207 Ortol, 465 Osarsal, 209 Osmic acid, 466 Osmium trioxide, 466 Osteonecrosis, 39 Osteosarcoma, 39 Osteosclerosis, 38 Osvaran, 209 Ouabain, 543 Oxalate crystals in urine, 133 Oxalates, 466 Oxalyl chloride, 467 Oxazine, 349 Oxazone, 349 Oxophenarsine hydrochloride, 467 Oxygen, 468 Oxymethylene, 365 Oxytetracyclene, 469 Ozone, 470 Pacitane hydrochloride, 321 Pain, abdorriinal, 62 in chest, 46, 54 in neck, 55 relief, 197 Pallor, 22 Palpebral edema, 104 Palpitation, 54 Paludrine hydrochloride, 296 determination, 149 Palusil hydrochloride, 296 Pamaquine, 504 Panmycin, 560 Panrone, 471 Pantocaine, 558 Pantopon, 471 Papaver album, 504 Papaver somniferum, 504 Par, 477 Para-acetaldehyde, 474 Para-acetylaminobenzaldehyde zone, 162, 471 thiosemicarba- INDEX Para-acetylaminobenzylidene zone, 471 thiosemicarba- Para-tert.-butyltoluene, 477 Paracain, $11 Para-aminobenzoic acid, determination, 162 Para-aminophenol, detection, 136 Para-aminosalicylic add, 472 Para-bromoaniline, 473 Para-chloroaniline, 473 Para-diaminodiphenyl, 261 Para-dicholorobenzene, 329 Paradust, 477 Para-ethoxyacetanilide, 212 Paraffin, 474 Para-formyl-acetanilide thiosemicarbazone, 471 Parakill, 477 Paraldehyde, 474 determination, 163 Paralysis, 99 ,, Paranitroaniline red, 347 Para-nitrosodimethylaniline, 475 Para-pheneddin, 476 Para-phenylenediamine, 207, 476 Paraphos, 477 Para-sulfonedichloroamidobenzoic acid, 476 Parathion, 477 determination, 163 Para-toluenediamine, 207 Para-toluidine, 479 Parazol, 330 Parazone, 471 Paresthesia, 102 Paris green, 242 Parkinsonism, 92 Parodtis, 75 Paroxyl, 209 Parthenocissus quinquefolia, 479 Pawpaw, 245 Pear oil, 230 Pelamis splaturus, 536 Pellederine, 479 Penethamate hydroiodide, 480 Penicillin, 480 Pennyroyal, 482 Pcntaborane, 482 Pentaboron-enneahydride, 482 Pentachloronaphthalene, 297 Pentachlorophenol, 483 Penta-erythritol tetranitrate, 483 Penta-(n-digalloyl)glucose, 556 Penta-erythrityl tetranitrate, 483 Penta-methyl -benzyl -p-rosaniline hyd rochloridc, 436 Penthrit, 483 Pentothal sodium, 571 Pentylenetetrazole, 483 determinadon, 163 therapeudc use, 194 Perawin, 559 Perborate, 484 T085323 I 619 Percaine, 328 determinadon, 152 Perchloroethylene, 559 Perforation peritonitis, 70 Peribronchitis, 50 Periostitis, 38 Perlon LT, 463 Perna disease, 297 Pernicious anemia, 119 Persian insect powder, 513 Perspiration, 27 Peru balsam, 484 Pervitin, 424 Petechia, 35 PETN, 483 Peyote, 423 Pfaffcnhiitchen, 361 Phaseolus coccineus, 484 Pbasin, 485 Phellandrene, 558 Phemerol chloride, 260 Phenacemide, 485 Phenacetin, 212 detection, 163 Phenacylchloride, 294 Phenantoin, 435 Phenedrine, 229 p-Phenetidin, 476 detection, 163 Phenetol, 372 p-Phenetolcarbamide, 347 Phenindamine, 485 Phenindione, 486 Phenobarbital, 486 Phenobarbitone, 486 Phenol, 487 detection, 164 Phenolphthalein, 483 detection, 164 Phenonyl, 486 Phenoquin, 305 Phenothiazine, 489 Phenoxur, 489 Phenoxybenzamine hydrochloride, 328 N-Phenoxyisopropyl-N-benzyl-/3-chloreth yla- mine, 328 Phentolamine, 490 Phenurone, 485 Phenylacetamide, 208 Pffenylacetylurea, 485 Phenylamine, 232 l-Phenyl-2-aminopropanol, 349 Phenylbisulfhydrate, 571 Phenylbutazone, 490 determination, 164 Phenylcinchoninic acid, 305 1 -Phenyl-1 -cyclopentyl-3 -piperidine-1 -propanol hydrochloride, 321 Phenyldichlorarsine, 492 Phenyldimethylpyrazolone, 236 620 ST 0853232 INDEX Phenylethylene, 545 p-Phenylenediamine, 207 Phenylethylmalonylurea, 486 Phenylglydnamide-p-arsonate, 585 Phenylhydrazine, 492 Phenylhydroxylamine, 492 2-PhenyM,3-indandione, 486 Phenylmercuric acetate, 422, 493 Phenylmercuric borate, 422, 493 Phenylmercuric nitrate, 422, 493 Phenylmercuric oleate, 422, 493 a-3-Phenylnaphthalene, 207 Phenytoin, 344 Phethenylate sodium, 493 Pheddine, 419 Philosopher's wool, 597 pHisoHcx, 493 Phloxin, 347 Phosgene, 494 , Phoshill, 477 Phosphine, 494 Phosphoretted hydrogen, 494 Phosphorodiamedic fluoride, 439 Phosphorus, 495 Phosphorus oxychloride, 497 Phosphorus pcntachloride, 498 Phosphorus sesquisulfide, 498 Phosphorus trichloride, 499 Photophobia, 108 Photosensitization, 34 Phthalein, 489 Phthalic acid anhydride, 499 Phthalylsulfathiazole, 500 Physeptone hydrochloride, 424 Physic-nut tree, 395 Physostigma venosum, 500 Physosdgmine, 500 Phytolacca decandra, 500 "Pick me up," 228 Picramic acid, detection, 164 Picric acid, 347, 501 detecrion, 165 Picrotoxin, 502 Pigeon berry, 500 Pilocarpine, 502 Pilocarpus jaborandi, 502 Pimpinellin, 374 Pine, 595 Pinene, 558 Pinus palustris, 586 Pinipicrin, 574 Pipcrazidine, 503 Piperazine, 503 Piper cubeba, 317 Piperidine derivatives, 207 Piperidone, 513 Piperocaine, 503 Pitch, 503 Pitayine, 517 Pituitary gland, 83 Planadalin, 286 Planocaine, 511 Planthion, 477 Plasmochin, 504 Plasmoquine, 504 detection, 165 Platinum, 504 Platinum hexachloride, 504 Plumbago, 370 Pneumoconiosis, 53 Pneumonia, 51 Podophyllotoxin, 505 Podophyllum, 505 Podophyllum peltatum, 505 Poikilocytosis, 119 Pois & gratter, 443 Poison ivy, 505 Poison oak, 505 Poisonous galerina, 366 Poison rye grass, 407 Poison sumac, 505 Poke, 500 Poke root, 500 Poke weed, 500 Polamidon, 424 Polychromatophilia, 119 Polycycline, 560 Polycythemia, 117 Polymyxin, 506 Polyuria, 78 Pontocaine, 558 Pool root, 362 Poolwort, 362 Poplar, 595 Porphyrinuria, 131 Potassium, 507 Potassium-antimony tartrate, 181 as emetic, 181 Potassium bromate, 266 Potassium chlorate, 291 Potassium hydroxide, 407 Potassium iodates, 387 Potassium iodide, 385 Potassium nitrate, 454 Potassium oxalate, 466 Potassium permanganate, 508 as antidote, 183 Potassium tellurite, 557 Potato, 539 Precipite blanc, 419 Precordial distress, 54 Prednisolone, 509 Prednisone, 509 A1-* -Pregnandione-3,20-dione-11,17a-21 -triol, 509 A1'4-Pregnandione- 17a,21-diol-3,ll,20-trone, 509 Presidon, 513 Prickly poppy, 238 Pride of India, 413 INDEX Primaquine, 510 Primidone, 510 Primrose, 510 Primula cortusoides, 510 Primula obconica, 510 Primula sieboldii, 510 Primula sinensis, 510 Privet, 404 Privine, 446 Procaine, 511 Procaine amide hydrochloride, 511 determination, 166 Profamina, 229 Proguanil hydrochloride, 296 Pronestyl hydrochloride, 511 Propacil, 515 Propanol-2, 393 Propanone, 211 2-Propenal, 216 Propene nitrile, 216 Prophenepyridamine, 512 Propisamine, 229 Proponesin, 393 Propylmercuric chloride, 219 2-Propylpiperidine, 311 Propylthiouracil, 512 determination, 166 Prostigmine bromide, 449 Prostigmine methylsulfate, 449 Prostradon, 21 Protamine insulin, 385 Protoanemonin, 521 Protoveradne, 590 Prune, 595 Prunus melanocarpa, 302 Pruritus, 34 Psoriasis, 34 Psychosis, 91 depressive, 91 manic, 91 Pterocarpus angolensis, 595 Ptosis of eyelids, 105 Puffer, 565 Pulcgone, 482 Pulmonary cancer, 53 Pulmonary edema, 51 treatment, 190 Pulmonary emphysema, 52 Pulmonary gangrene, 53 Pulmonary hemorrhages, 52 Punica granatum, 479 Punicine, 479 Pupil, rigidity of, 108 Puran, 295 Purging nut tree, 395 Purpura, 35 Pustular erupdons, 33 Pyelectan, 388 Pyoctanimum aureum, 250 Pvramidon. 225 ST 0853233 Pyranisamine, 515 Pyrathin, 427 Pyrethyldione, 513 Pyrethrum flowers, 513 Pyribenzamine, 235, 584 Pyricidin, 392 Pyridine, 514 Pyridine-3-carboxylic acid, 451 Pyridoxine, 515 Pyrilamine, 515 determination, 139 Pyrocatechol, detection, 166 Pyrogallic acid, 515 Pyrogallol, 515 detection, 166 Pyrolucite, 411 Quartz, 533 Quelicinchloride, 545 Quicksilver, 420 Quillaja saponica, 527 Quinacrine, 516 detection, 166 Quinidine, 517 Quinine, 518 detection, 167 Quinophan, 305 Quinosol, 384 Radium, 519 Ranunculus scleratus, 520 Rat's bane, 329 Rattlesnake, 535 Rauschbeere, 588 Rauwolfia serpentina, 521 Rayless golden rod, 362 RDX, 320 Rectum, ulceration of, 74 Reflexes, decreased, 100 increased, 100 Regitane hydrochloride, 490 Regurgitation, 70, 71 Renal congestion, 77 Renal excretion, decreased, 79 increased, 79 Reserpine, 521 Resorcin green, 347 Resorcinol, 521 detection, 168 Respiration, arrest of, 44 artificial, 192 Biot type, 43 Cheyne-Stokes type, 43 increase of, 40 Kussmiul type, 43 slowing of, 41 Respiratory depression, treatment. 192 Restlessness, 84 Retching. 70 521 622 ST085323U INDEX Reticulocytosis, 120 Retinal hemorrhages. 111 Retrobulbar neuritis, 111 Rhinitis, 46 Rhodalline, 572 Rhodamine B, 234 Rhodanides, 568 Rhododendron (erugium, 378 Rhododendron Aavum, 378 Rhododendron pontkum, 378 Rhodomyrtus macrocarpa, 363 Rhodotypos kerrioides, 522 Rhus diversiBora, 505 Rhus radicans, 505 Rhus toxicodendron, 505 Rhus vermifera, 505 Rhus vernix, 505 Richweed, 362 Ricin, 286 i Ridnine, 286 Ricinus communis, 286 Rimnifon, 392 Ringing of ears, 115 Risus sardonicus, 96 Rosary beads, 205 Rosemary oil, 522 Rosmarinus officinalis, 522, 558 Rotenone, 513 Rumex acetosa, 523 Sabadine, 589 Sabinol, 558 Saccharin, 523 Saccharinol, 523 Saccharinose, 523 Saccharoh 523 Saffron, 523 Safranine, 234, 347 Safrole, 524 Sage, 524 Sal. ammoniac, 227 Salicydic acid, 525 detection, 168 Salicylamide, 524 Saline, therapeutic use, 188 Salivary glands, inhibition, 74 stimulation, 74 Salivation, 66 Salmiac, 227 Salvarsan, 245 Salvia offidnalis, 524 Salyrgan, 416 Sand, 533 Sanochrysin, 369 Santonin, 526 detection, 168 Sapindus saponaria, 527 Saponaria officinalis, 527 Saponins, 527 Saprol, 315 Saxin, 523 Scarlatiniform eruptions, 31 Scheelium, 586 Schleicheria, 533 Schweinfurt green, 242 Scilla maritima, 528 Scopolamine, 528 Scorpion, 529 Scotoma, 114 Scratch wort, 443 Scurocaine, 511 Sea onion, 528 Sea-snake, 536 Secale cornutum, 351 Sedicin, 530 Sedimentation rate, 125 Sedormid, 530 Sedulon, 513 Selenium, 530 detection, 169 Selenium dioxide, 531 Selenium oxyfiuoride, 531 3-Scmicarbazido-benzamide, 532 Semikon, 427 Senecine, 532 Senedo burchelli, 532 Senecio canicida, 532 Senecio ilicifolius, 532 Senedo vulgaris, 532 Senccionine, 532 Septojodid, 385 Sequestrene, 357 Serjana lethalis, 378 Serpasil, 521 Sevicaine, 511 Shadow cells, 120 Sheep laurel, 378 Shellac, 533 Shock, circulatory, 56 treatment; 193 Shortness of breath, 54 Siderosis, 53 Silica, 533 Silicon carbide, 286 Silicon dioxide, 533 Silicosis, 53 Silon, 463 Silver, 534 Silver nitrate, 534 Sincaline, 302 Sinus, irritation of, 48 Skin, black color, 26 burns, 36 corrosion, 36 cyanosis, 23 dry and scaly, 28 gangrene, 36 granuloma, 36 greenish color, 26 hemorrhages, 32, 35 INDEX ST 0853235 Skin, lividity, 23 pallor, 22 pink color, 25 ulceration, 36 vesication, 35 warts, 36 yellow color, 26 Smaldne, 306 Snake venom, 535 Soap, 537 Soap root, 527 Sodium acetylarsanilate, 239 Sodium p-aminophenylarsenate, 538 Sodium arsanilate, 538 detection, 169 Sodium aurothiomalate, 369 Sodium azo-a-naphtholsulanilate, 465 Sodium bromate, 266 Sodium bromide, 266 Sodium chloropladnate, 504 Sodium 3-diamino-4-dihydroxy-arsenobenzene- methanol suifoxylate, 448 Sodium diphenylhydantoinate, 344 Sodium ethylmercurithiotalicylate, 422 Sodium 5-ethyl-5-(l-melhyIbutyl)-2-thiobarbit- urate, 571 Sodium fluoride, 363 Sodium fluoroacetate, 538 Sodium hydroxide, 407 Sodium hypochlorite, 306 Sodium iodatc, 385 Sodium iodide, 386 Sodium nitrate, 454 Sodium nitrite, 455 Sodium nitroferricyanide, 461 Sodium nitroprusside,'461 Sodium perborate, 484 Sodium phetenylate, 493 Sodium N-phenylglycinamide-p-arsonate, 585 Sodium 5-phenyl-5-(2-thienyl)-hydantoinate, 493 Sodium rhodanide, 568 Sodium silicate, 594 Sodium silicofluoride, 363 Sodium sulfite, 554 Sodium sulfocyanate, 568 Sodium tellurite, 557 Sodium thiocyanate, 568 Sodium p-toluenesuifonchloramide, 290 Solanidin, 539 Solanine, 539 detection, 169 Solanum dulcamara, 539 Solanum nigrum, 539 Solanum tuberosum, 539 Solantoin, 344 Solantyl, 344 Somnifen, 540 Somnolence, 87 Somonal, 486 Sorrel, 523 Speech, impairment of, 93 Sphyroena barracuda, 256 Spider bite, 540 Spinal cord, 84 Spinal pressure, increased, 93 Spindle tree, 361 Spirit blue, 234, 347 Spirit of turpentine, 586 Spirocid, 209 Spleen, enlargement of, 81 shrinkage of, 81 Spotted cow bane, 304 Spruce, 595 Spurge flax, 322 Spurred rye, 351 Squaw mint, 482 Squaw weed, 362 Squill, 528 Squint, 109 Staggering, 98 Stenosis, bronchial, 51 esophageal, 69 gastric, 70 Sdngaree, 541 Sting bull, 578 Stinging bean, 443 Sdngray, 541 Stinkweed, 322 Stippled cells, 120 Stomach, corrosion, 70 inflammation, 69 perforation, 70 strictures, 70 ulceration, 70 Stomatitis, 65 Stools, bloody, 72 Stovarsolan, 209 Stovarsurol, 209 Strabismus, 109 Stranguria, 80 Strawberry tree, 361 Streptokinase-streptodornase, 541 Streptomyces aerofaciens, 301 Streptomyces fradiae, 448 Streptomyces griseus, 542 Streptomyces rimosus, 469 Streptomyces venezuelae, 290 Streptomycin, 542 determination, 170 Strictures, 70 Strophanthin, 543 Strophanthus hispidus, 543 Strophanthus kombl, 543 Strychnine, 543 detection, 170 Strychnos nux vomica, 543 Stupor, 88 Styracine, 484 Styrene, 545 623 624 ST 0853236 INDEX Styrol, 545 Succinate disodium, 545 Succinylcholine chloride, 545 Sucoitrin chloride, 545 Sucrol, 347 Sudan IV, 347 Sulfadiazine, 546 crystals in urine, 134 determination, 170 Sulfaguanidine, 547 Sulfanilamide, 547 crystals in urine, 134 determination, 170 2-Sulfanilamidopyridine, 546 2-Sulfanilamidopyrimidine, 548 Sulfanilamidothiazole, 549 Sulfapyridine, 548 determination, 171 Sulfarsphenamine, 549 . Sulfathalidine, 500 Sulfathiazole, 549 crystals in urine, 134 determination, 171 Sulfhemoglobin, 24 Sulfisoxazole, 550 10-Sulfo-/9-naphthalene-azo-betanaphthol, 3 47 Suifobromophthalein sodium, 551 Sulfocyanate, 568 Sulfonal, 551 Sulfonamide, crystals in urine, 134 2-Sulfonamidothiazolc, 549 p-S-Sulfon-dichloramido-benzoic acid, 476 Sulfonmethane, 551 Sulfur, 551 Sulfur dioxide, 552 Sulfuric acid, 553 Sulfuric chlorhydrin, 299 Sulfurous acid, 554 Sulfurous anhydride, 552 Sulfurous oxide, 552 Sulfurous oxychloride, 571 Sulfuryl chloride, 554 Suramin, 554 Swallowing, difficulties in, 68 Sweet birch oil, 437 Swift's disease, 34 Sykose, 523 Sympamine, 229 Syncaine, 511 Syncope, 55 treatment, 195 Syndrox, 424 Syntho-San, 260 Tachycardia, 57 Talcum, 555 Tanacetum vulgare, 555 Tannic acid, 556 as antidote, 181 determination, 171 Tannin, 556, 574 Tansy, 555 Tapazole, 428 Tar, 556 Tar camphor, 446 Tares, 407 Tartar emetic, 234 therapeutic use, 181 Tartaric acid, 556 as antidote, 183 Taste, bitter, 66 increased, 66 loss of, 66 metallic, 66 sweetish, 66 unpleasant, 66 Taumellolch, 407 Taxicatine, 556 Taxin, 556 Taxus baccata, 556 TEA chloride, 560 TEAB, 560 Teaberry oil, 437 Tebethion, 471 Tebezon, 471 Teeth, corrosion, 38 deposit, 38, 63 discoloration, 38 impregnation, 38, 64 Teflon, 557 Tellurium, 557 Tellurium oxide, 557 Tellurous acid, 557 Tenaline, 427 Ten eighty (1080), 538 Tenesmus, 73 TEP, 562 TEPP, 562 Tcrpenes, 558 Terpineol, 558 Terpin hydrate, 558 Terra alba, 396 Terramycin, 469 Testes, atrophy of, 82 Testoviron, 437 Tetrabromofluorescein, 347, 349 Tetracaine, 558 Tetrachloroethane, 559 Tetrachloroethylene, 559 Tetrachloromethane, 283 Tetracil, 345 Tetracycline, 560 Tetracyl, 345 Tetracyn, 560 Tetradine, 345 Tetraethylammonium bromide, 560 Tetraethylammonium chloride, 560 Tetraethyl lead, 561 Tetraethyl pyrophosphate, 562 Tetraethylthiuram disulfide, 345 INDEX ST0853237 625 ac.-Tetrahydro-0-naphthylamine, 563 Tetrahydronaphthalene, 563 detection, 172 2-( 1,2,3,4-Tetrahydro-1 -naphthyl) -imidazo line, 564 Tetrahydroxoline, 564 Tetraiodophenolphthalein, 564 Tetraiodophthalein, 564 Tetralin, 559, 563 detecdon, 172 Tetramethyldiaminobenzophenonimide, 250 Tecramethylammonium bromide, 560 Tetramethylammonium chloride, 560 Tetramethylenetetramine, 207 Tetramcthylene disulfotetramine, 564 Tecramethylthionine chloride, 432 Tetramethylthiuram disulfide, 207 Tetranitromethane, 565 Tetraodondae, 565 ,T._ u v Tetrodotoxin, 565 Tetryl, 565 Thallium, 566 detecdon, 172 Thallouj acetate, 566 Thallous sulfate, 566 Thenylene, 427 Thenylpyramine, 427 Theobromine, 567 Theobromine sodium salicylate, 568 Theophylline, determination, 172 Theophylline ethylenediamine, 224 Thevetia nereifolia, 464 Thevetin, 464 Thioacetazone, 471 Thiamine hydrochloride, 568 Thiantoin sodium, 493 Thiazinc, 349 Iniazone, 349 2-Thiazylamine, 226 Thimersal, 422 Thiobicina, 471 Thiocarbamide, 573 Thiocarbazil, 471 Thiocyanate, 568 determination, 172 Thiodiphenylamine, 489 determination, 172 Thioglycerol, 570 Thioglycol chloride, 444 Thioglycolic acid, 570 Thiokol, 570 Thiomerin sodium, 416 Thiomicid, 471 Thion-dust, 477 Thionylchloride, 571 Thioparamizone, 471 Thiopental sodium, 571 Thiopentone sodium, 571 Thiophos, 477 Thioprene, 570 2-Thio-l,3-pyrimidin-4-one, 512 Thioresorcinot, 571 Thio-rubber, 570 Thiosemicarbazone, 471 Thiosinamine, 572 Thiosulfate, detection, 173 Thiotal sodium, 571 Thiotebenzin, 471 Thiouracil, 572 determination, 173 Thiourea, 573 determination, 173 Thirst, 68 Thiuranide, 345 Thomas slag, 573 Thorazine, 299 Thorium, 574 determination, 174 Thorium oxide, 574 Thorn apple, 322 Thorotrast, 574 Thrombocytopenia, 121 Thuja occidentals, 574 Thuja plicata, 595 Thujetic acid, 574 Thujone, 558, 574 Thymol, 575 Thyroid, 83 Tibione, 471 Tin, 575 Tin oxide, 575 Tinnitus, 115 Tiobicina, 471 Tiocarone, 471 Tiosecoto, 471 Tirian hydrochloride, 296 Tityus serrulatus, 529 TNT, 3* J Toad fish, 565 Toluazotoluidine, 223 Tolu balsam, 484 Toluene, 576 determination, 174 Toluenesulfonamide formaldehyde, 445 2- o-Toluidine, 207 p-Toluidine, 479 Toluifera pereira, 484 Toluylene diamine, 372, 576 Toluylene diisocyanate, 577 3- (N'-p-Tolyl-N'-m-hydroxyphenylaminometh- yl)-imidazoline, 490 Tongue, inflammation of, 66 Topocaine, 511 Toxaphene, 577 Toxicodendrol, 505 Toxilic anhydride, 40 Tracheitis, 50 Trachinus draco, 578 Treburon, 578 Tree of life, 574 626 ST 0853238 INDEX Tremetol, 362 Tremon, 97 Trethylene, 579 Tri, 579 Tribromoethanol, 578 determination, 174 Tribromomethane, 269 Trichlorine nitride, 459 Trichloroacetaldehyde, 288 Trichloroacetaldehyde monohydrate, 289 Trichloroethene, 579 Trichloroethylene, 579 Trichloromethane, 295 Tri-Clene, 579 Tricresytphosphate, 583 Tridione, 581 Trielene, 579 Triethylene melamine, 580 1,2,3-Trihydroxybenzene. 515 Trihexyphenidyl hydrochloride, 247 Triiodomethane, 389 Trilene, 579 Trilline, 579 Trimethadione, 581 3.4.5- Trimethoxyphenylethylamine, 423 2.4.5- Trimethoxy-l-propenyIbenzene, 247 l,3,7-Trimethyl-2,6-dihydroxypurine, 273 3.3.5- Trimethyl-2,4-oxazolidinedione, 581 Trimethylene, 320 Trimethylenetrinitramine, 320 Trimethyloxazolidine*2,4-dione, 581 Trimeton, 512 Trinitramine, 320 Trinitroanisole, 581 Trinitrobenzene, 582 Trinitroglycerol, 459 2.4.6- Trinitrophenol, 501 Trinitrophenylmethylnitramine, 565 Trinitrotoluene, 582 detection, 174 Trinitrotrichloromethane, 298 Triorthocresyiphosphate, 583 Tripelennamine, 584 determination, 139 Tripoton, 512 Trismus, 96 Tropeolin 000 NI, 465 Tropine mandelate, 377 Tropococaine, 584 Tryparsamide, 585 Tubercazone, 471 Tung nuts, 585 Tung oil, 585 Tungsten, 586 Turpentine, 586 Twitchings, 22 of lips, 22 TY, 320 Tympanites, 73 Tyrosine, crystals in urine, 133 Tyvid, 392 Tyzine hydrochloride, 564 Udolac, 325 Ulceration of esophagus, 69 of rectum, 74 of skin, 36 of stomach, 70 of urethra, 81 of urinary bladder, 80 of uterus, 83 Ultramarine, 587 Umbradil, 389 Unconsciousness, 88 treatment, 199 Undecylenic acid, 587 Uradal, 286 Uremia, 79, 127 Urethan, 587 detection, 174 Urethra, ulceration of, 81 Urginea maritima, 528 Uric acid level in blood, 128 Urinary bladder, hemorrhages, 80 incontinence, 81 inflammation, 80 neoplasms of, 80 spasms of, 80 ulceration of, 80 Urine, acetoacetic add in, 132 acetone in, 132 bilirubin in, 132 blood in, 130 color of, 129 crystals in, 133 cystine in, 133 ethereal sulfates in, 133 hemoglobin in, 130 leucine in, 133 methemoglobin in, 131 porphyrin in, 131 oxalates in, 133 sulfonamides in, 134 tyrosine in, 133 urobilin in, 132 urobilinogen in, 132 Urobilinuria, 132 Urticaria, 32 Urushiol, 505 Uterus, corrosion of, 83 hemorrhages of, 82 ulceration of, 83 V-8, 369 Vabrocid, 458 Vaccinium myrtilis, 558 Vaccinium uligenosum, 588 Vagina, corrosion of, 83 Vagolysen, 347 Valerian, 558 index ST 0853239 Valzin, 347 Vanadium, 588 Vanadium pentoxide, 588 Vanillin, 484 Vapethos, 477 Varidase, 541 Vascular degeneration, 59 Vascular spasms, 36 Vasoconstriction, 59 Vasodilatadon, 59 Vegolysin, 375 Ventox, 216 Ventricular fibrillation, 58 Veratramine, 589 Veratridine, 589 Veratrine, 589 Veratrum album, 590 Veratrum grandifolium, 589 Veratrum viride, 218, 589 Veriloid, 218 Verpa lecheguana, 378 Versene, 357 therapeudc use, 187 Vesication, 55 Vesicular eruptions, 232 Vesdbular disturbances, 116 Vetchling, 399 Victoria blue, 234 Victoria yellow, 347 Vidine, 302 Vinegar, 210 therapeudc use, 183 Vinethene, 346 Vinylcyanide, 216 Vinyl ether, 346 Violet B, 234 Violet RB, 234 Viosterol, 592 Viper, 536 Virginia creeper, 479 Visda saliva, 399 Visual disturbances, 112 Visual field, restriction of, 114 widening of, 114 Vitamin A, 590 Vitamin Bi, 568 Vitamin Bg, 515 Vitamin Di, 592 Vitamin D2, 592 Vitamin Ds, 592 Vocal cord, paresis of, 49 Vomiting, 61 therapeudc use of, 180 Vomiting sickness of Jamaica, 264 Waxpaxin, 593 Warts, 36 Wasp sting, 257 Water blue, 347 Water glass, 594 Water-hemlock, 304 Water moccasin, 535 Weever fish, 578 Wernicke syndrome, 91 Western red cedar, 595 Westocaine, 511 Westrosol, 579 White amanita, 223 White arsenic, 239 White bole, 396 White cedar, 413 White flag, 465 White hellebore, 590 White sanicle, 362 White snake root, 362 White vitriol, 598 Whortleberry, 588 Wild pepper, 322 '"U'Wild wood vine, 479 Windsor bean, 362 Wintergreen oil, 437 Withdrawal symptoms, 94 Wolfram, 586 Wolfsbane, 215 Wood, 594 Wood alcohol, 425 Woody nightshade, 346 Worm seed, 526 Worm weed, 206 Wrightia tincturea, 384 Xanthates, 207 Xanthopia, 114 Xanthotoxol, 374 Xylene, 595 Yellow cedar, 574 Yellow oleander, 464 Yellow vision, 114 Yerba dellos Perros, 532 Yperite, 444 Zentxopil, 344 Zephiran chloride, 595 Zephirol, 595 Zinadon, 392 Zinc, 596 determination, 175 Zinc chloride, 595 Zidc cyanide, 597 Zinc dichromate, 597 Zinc oxide, 597 Zinc phosphide, 598 Zinc stearate, 598 Zinc sulfate, 598 therapeutic use, 181 Zinc vitriol, 598 Zinc white, 597 Zygadenine, 599 Zygadenus venosus, 599 627