Document G6w28eLngr4n3mE2r6yM6EBjY
OUTLINE OF PROPOSED HOKOORAPK ON ASBESTOSIB
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Saranac Laboratory .Study under Prant Iron Aabaatos AeaoQlftUon ,
PART I KUKAN AS5EST0SI3
1 Human Pathology - a atudy of 25 autopay ooeaa, Illustrated
2 X-ray Pattern* In Aabeatoala, Illuatratad
0 Aah and Mineral Value* in Hunan Aabeatoala
4 CoQplieationa of Aabeatoala
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(a) Susceptibility to infection
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1 Tuberouloua 11 Non-Tuberculoua ill Cancer of the lung
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5 Disability, cauea* and comparison with elllcoala
6 Dlagnosia
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(a) History of adequate exposure (b) X-ray filn pattern (c) Physical examination (d) Aabeatoala bodies in aputun, their algnlflcanca
L* >- ... .
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(2) PAST IZ Sxoerlaental Aafrafl^ig
Z Methods <
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(a) Inhalation exposure to plant dusta.
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(b) Znjeotlon Into lungs through trachea of pure ainerals.
(o) Injection of pure minerals into other organs.
2 Species Susceptibility
Man, guinea pigs, rabolta, oats, white alee and rata,
dogs.
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3 Peculiar Charaoterlatloe of Asbestoels
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(a) Unusual localltalon of chrysotlle fibre in lunga. (b) Rate of resultant tissue reaction oore rapid than to
ouartz. (o) Reaction to chryeotlle not progreaalve after exposure
ceases; again the reverse of the situation in silicosis,
(d) Asbestosls Bodies
1 Coaposltlon and cathode of foraation.
il Occurence in different epeelee.
ill Foraation does not parallel developaent of fibrosis,
iv Oradual disappearance after exposure eeasse.
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4 Comparative Effects of Different Aabestlfora minerals. '
(a) Canadian Chryeotlle.
(b) Arizona Chryeotlle. low iron.
(c) Crooldollte
1 Bolivian speoloen, stiff and elastic.
11 South Afrioan, soft and flexible.
(d) Anthophylllte
(e) Aaoslte.
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(f) Trenollte.
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5 Effeots of Control Minerals .
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(a) Orannular Serpentine, sane ohenlcal coaposltlon as
. chryeotlle. .
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(b) Olass Wool, a synthetic silicate fibre.
(o) Bruoite, a fibrous aagneslua hydroxide aloost free of
silica .
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6 Chemical Coaposltlon of Asbestlfora ainerals in Relation to
Irritation.
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(a) Nothing In coaposltlon correlated with relative lrrltatir.
capacity.
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(b) Prellalnary acid treataent
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1 Hydroohlorle sold 11 Carbon!e sold '
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(c) Effeots of Alualnua
7 Physioal Properties in Relation to Irritation
(a) Length of fibre Jb) Effeot of Cruehing (o) Heat treataent
8 Mature and Significance of Aabeatoala Body
(a) Formation (b) Protective effeot preventing further Irritation Co) Ultlaate eolubllity in tiseue
9 Theoriea of Action of Aabeetifora Minerala
(a) Chemical - reaeone for conalderlng invalid (b) Meohanioal - experimental demonstration of.
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10 Compileatlone
(a) Infection, tuberculosis and other varieties
(b) Cancer of lung - experimental data suggestive but not
proven .
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11 Disability
12 Essential Features of Katardous Exposure
(a) Mature of dust - fibrous component and sits factors
(b) Atmospheric Concentrations - probably lover than for
quarts
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1 Inadequacy of standard lnplnger sampling method ` which does not oollect the dangerous fibres
11 Eleotrostatlc precipitat*<sampllng preferable but . method must be modified
(c)'Duration of Exposure
13 Recommendations for a Mew Standard of Safe Atmospheric Con . centratlone of Asbestos Dust
. (a) The Quasi-official standard-of 4 to 5 million particles
per eu. ft.
(b) Work upon better method of sampling
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(c) necessity for oomparlaon of results with X-ray findings in employees
14 Prevention
(a) Chemical means not practical
ir I
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1 Acl&osla necessary to dissolve fibre in lunga worst '
than Aabeetoala
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11 Aluminum Therapy Inapplicable
ill Chief reliance still upon dust prevention with '
special snphasla upon the fibrous components
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