Document G6rvrNmjzwV529VwRNzbw2L2q

TD -> / f Ke 0019273 November 29, 1956 Dr. Roy C. A. Bock Ethyl Corporation P. O. Box 341 Baton Rouge 1, Louisiana Dear Roy: I send you herewith, without further delay, the information now available on the toxicity of AF-3. A few more data are in, but none of them contribute anything additional from the aspect of hygienic practice. I shall let you have additional reports later when they are available. We do not distribute brief reports of this hurried type very widely, and that is why you have not had this previously. It is the only extra copy I have. I think it would be wise if you were to suggest to the appropriate pedple there, apropos of my telephoned comment on the information obtained and circulated by some one on manganese, that no such information should be circulated for application to potential hazards, until it has been looked at and commented on by the responsible medical people. Sincerely yours, Robert A. Kehoe, M. D. RAK ef Enc. Witherup's letter of April 23, 1956 to Dr. Hymin Shapiro 001S274 COPY: Dr . R. A. Kehoe Dr. Hymln Shapiro, Res ear c h Pl anni ng Coor di nat or , Ch e mi c a l Res e a r c h Di v i s i on, Et hy l Cor por at i on, 1600 We s t Ei ght Ki l e Road, F e md a l e 20, Det r oi t , Mi c hi gan. . Oc t o b e r 6, 1056 ' De a r Do c t o r Shapi r o: We hav e now c ompl et ed t he t es t s n e c e s s a r y t o e s t a b l i s h t he c l a s s i f i c a t i o n of AP- 3 f o r s hi pp i n g r egul at i ons . The r es ul t s of t hes e t es t s s uf f i c e t o i dent i f y AP- 3 as a Cl as s B poi s on as def i n e d i n t he r egul at i ons of t he I nt er s t at e Commer c e Commi s s i on, Tar i f f No. 8, Se c t i o n 73, 343. Th e r ul es f o r s hi ppi ng s u c h poi s ons wi l l appl y t o AP- 3. A det ai l e d r epor t on t he t es t s wi l l be s ubmi t t ed as s oon as I t c an be pr epar ed. The r es ul t s al s o emphas i z e t he pr ec aut i ons wh i c h s houl d be ex er c i s ed i n pr epar i ng and wo r k i n g wi t h t hi s mat er i al , of 20 r at s ex pos ed f o r a s i ngl e per i od of 1 h o u r I n a n at mos pher e c o n t a i n i n g 2. 0 r ag. of AP- 3 per l i t er of ai r , 18 di ed wi t h i n 3 day 3. Thi s ma t e r i a l and pr epar at i ons c o n t a i n i n g I t , s houl d be kept i n t i ght l y cl osed cont ai ner s and used under condi t i ons i ns ur i ng no I nhal at i on of I t s- v apor s . I n t he pr oc es s of ma k i n g AP- 3, t he r e a c t i o n pr oduc t t hat I s t ak en f r o m t he pot and put i n t he r ec t i f y i ng c o l u mn s houl d be handl ed wi t h es s ent i al l y t he s ame pr ec aut i ons as t he pur i f i ed mat er i al . Si n c e r e l y y our s , / S/ Sy l v a n Wi t h e r u p Se n i o r Re s e a r c h As s oc i a t e SW: bf co: Dr . R. A. Kehoe Dr . F. F. Hey r o t h HE 0018275