Document G6rZxnaO18nabg8xvwe03zooq

r 0 GENERAL CHEMICAL EXPOSURE (1) MONSANTO STUDY - J. Killeen (3/78) SCOPE: - 565 former Monsanto employees. OBJECTIVES: - Proportional mortality analysis of cancer deaths by site and occupational exposure. CONCLUSIONS: - No statistically significant excesses in (9) digestive categories. - No apparent prostate cancer excesses in department. - No prior reasons for suspecting excess genital, diges tive cancer deaths. - Non-statistically significant excess in digestive genital cancer deaths. (2) NIOSH STUDY - R. Spirtas (7/78) SCOPE: - 465 death certificates of 484 employee deaths between 1950 and 1976. OBJECTIVES: - Epidemiological study of employee deaths based upon PMR & PCMR by race, site, age, exposure period, and national origin. CONCLUSIONS; - Slight excess of digestive, genito-urinary cancer, not associated to specific etiologic agent. Not statisti cally significant when compared to Hampden county races. R&S159538 o GENERAL CHEMICAL EXPOSURE (Cone) (3) STUDY/VISIT BY PETERS/MONSON (6/78) (OSilA Health Hazard Survey) SCOPE: - Analysis/Evaluation o (2) prior studies: Monsanto (Killeen) NIOSH (Spirtas) OBJECTIVES: - Determine whether further studies or medical evaluations are necessary. CONCLUSIONS: - Data from both studies are consistent with no demonstrable effect of working at Springfield Plant in cause of death. (4) UNIVERSITY OF PITTSBURGH STUDY - MARSH (12/79) SCOPE: - 2490 total cohort of employees during period 1949 - 1966. OBJECTIVES: - Analyze long-term, cause-specific mortality patterns for Monsanto-Springfield employees and ex-employees and com pare to mortality experience among general populations in U.S-, Massachusetts., and Hampden County. CONCLUSIONS - Fever deaths from any cause ... less than expected. - Fewer deaths from all forms of cancer ... than expected. - Slightly more deaths from digestive and genito-urinary cancers ... than expected. - No new evidence was uncovered to show any worker-health problem at Springfield Plant. V i' R&S159539 j 0 GENERAL CHEMICAL EXPOSURE (Cont) (5) UNIVERSITY OF PITTSBURGH STUDY (3) MARSH (10/31) SCOPE; - 2479 total cohort of employees and ex-employees during period 1950 - 1976. OBJECTIVES: - Determine if any association exists between digestive, genito-urinary cancers and certain chemical agents and/ or conditions specific to work environment. CONCLUSIONS: - Methodological problems, small numbers, and questionable exposures did not permit definite conclusion. - Statistically significant rectal cancer excess, and nearly statistically significant prostate cancer ex cesses in specific OEC ... may warrant further study. n (6) UNIVERSITY OF MASSACHUSETTS MASTER THESIS - T. Liebling (2/82) SCOPE: - 211 total cohort of employees during period 1976-1980. OBJECTIVES: - Identify any excess mortality associated with particular chemical exposures or work areas in the plant. CONCLUSIONS: - Significant excess of buccal/pharyngeal cancer observed in employees who may have been exposed to formaldehyde. R&S159540