Document G6d3zoEVdx3GXpxrnRE79dvbN

HFM -003516 58. Bastenie, P.A.; Ermans, A.M., and Deles- 76. Parker, L.N., et al.: Thyroid carcinoma' pessc, G.: Chronic lymphocytic thyroiditis and after exposure to atomic radiation. Ann. Intern- cancer of the thyroid. In: Bastenie, P.A., and Med. 80:600-604,1974. Ermans, A.M. (eds.): Thyroiditis mid Thyroid 77. Hayek, A.; Chapman, E.M., and Craw Function. Oxford: Pergamon Press, 1972. ford, J.D.: Long-term results of treatment of Pp. 159-170. thyrotoxicosis in children and adolescents with; 59. Hayes, H.M., Jr., andFraumeni, J.F., Jr.: radioactive iodine. N. Engl. J. Med. 283:949-: Canine thyroid neoplasms: epidemiologic fea 953,1970. tures. J. Natl. Cancer. Inst. 55:931-934,1975. 78. Dobyns,B.M.,etal.:Malignantand benign' 60. Crile, G., Jr., and Haxard, J.B.: Incidence neoplasms of the thyroid in patients treated for . of cancer in struma lymphomatosa. Surg., hyperthyroidism: a report ofcooperative thyro- . Gynecol., Obstet. 115:101-103,1962. toxicosis therapy follow-up study. J. Clin. 61. Duffy, B,J., Jr., and Fitzgerald, P.J.: Can Endocrinol. Metab. 38:976-998,1974. cer of the thyroid in children: a report of 28 79. Conard, R.A.: A 20-year review ofmedical:- cases. J. Clin. Endocrinol. 10:1296-1308,1950. findings in a Marshallese population accident 62. Clark, D.E.: Association of irradiation tally exposed to radioactive fall-out. Upton, with cancer of the thyroid in children and ado New York: Brookhaven National Laboratory, lescents. JAMA 159:1007-1009,1955. 1973. 63. Pincus, R.A.; Reichlin, S., and Hcmpel- 80. Schoenberg, B.: Multiple primary malignant mann, L.H.: Thyroid abnormalities after neoplasms: the Connecticut experience, 1935-:: radiation exposure in infancy. Ann. Intern. 1964. New York: Springer Verlag. (In press.) V Med. 66:1154-1164,1967. 81. Horm, J.W.: Personal communication. 1 64. Winship, T., and Rosvoll, R.V.: Thyroid 82. Schottenfeld, D., and Berg, J.W.: Incidence ..- . carcinoma in childhood: final report on a 20- of multiple primary cancers. IV: Cancers of the/ year study. Clin. Proc. Child. Hosp. 26:327- female breast and genital organs. J. Natl. Can-. - 348,1970. cer Inst. 46:161-170,1971. 65. DeGroot, L.J., and Paloyan, E.: Thyroid 83. Schottenfeld, D.:Therelationshipofbreast * carcinoma and radiation: a Chicago epidemic. cancer to thyroid'disease. J. Chronic Dis. 21: JAMA 225:487*91,1973. 303-313,1968. -.if. 66. Consequences of thyroid radiation in chil 84. Itoh, K., and Maruchi, N.: Breast cancer in;: ; dren. (Editorial) N. Engl. J. Med. 292:204-205, patients with Hashimoto's thyroiditis. Lancet. 1975. 2:1119-1121,1975. % 67. Refetoff, S., et al.: Continuing occurrence 85. Maruchi.N,;Annegers, J.F.,and Kurland,!' of thyroid carcinoma after irradiation to the L.T.: Hashimoto's thyroiditis and breast can neck in. infancy and childhood. N. Engl. J. cer. Mayo Clin. Proc. 51:263-265,1976. Med. 292:171-175, 1975. 86: Mittra, I., and Hayward, J.L.: Hypotha-' 68. Becker, F.O.; Economou, S.G.; South- lamk-pituitary-thyroid axis in breast cancer. :. wick, H.W., and Eischstein, R.: Adult thyroid Lancet 1:885-888,1974. ': ;! ,, cancer after hegdand neck irradiationininfancy 87. Mittra, L; Hayward, J.L., and McNeiUy,'1 and childhood. Arm. Intern. Med. 83:347-351, A.S.: Hypothalainjc-pituitary-prolactin axis in 1975. ' breast cancer. Lancet 1:889-891,1974.. -/ 69. Favus, M.J., et al.: Thyroid cancer oc 88. Mittra, LrMammotropiceffect ofprolactin - curring as a late consequence of head and neck enhanced by .thyroidectomy. Nature 248^25-irradiation. N.. Engl. J. Med. 294:1019-1025, 526,1974. 1976. 89. Schottenfeld, D.: Epidemiology of breast1? 70. Modan, B., et al.: Radiation-induced head cancer. Clin. Bull: 5:135-143( 1975. ? and neck tumors. Lancet 1:277-279,1974. 90. Henderson. B.E., et al.: Elevated serum.;::: 71. Shore, R.E.; Albert, R.E., and Pasternak, levels of estrogen and prolactin in daughters of !- B.S.: Follow-up study of patients treated by patients with breast cancer. N. Engl. J. Med. /. X-ray epilation for tinea capitis. Arch. Environ. 293:790-795, 1975. Health 31:21-28,1976. 91. Sommers, S.C.: Endocrine abnormalities-.. 72. Hempelmann, L.H., et al.: Neoplasms in . in women with.breast cancer. Lab. Invest. 4:' persons treated with X-rays in infancy: fourth 160-174,1955. survey in 20years. J. Nad. Cancer Inst. 55:519- 92. Beatson, G.W.: On the treatment of inop--- 530.1975. erable cases of carcinoma of the mamma-- - 73. Silverman, C., and Hoffman, D.A.: Thy suggestions for a new method of treatment with roid tumor risk from radiation during child illustrative cases. Lancet 2:104-162,1896. l? hood. Prev: Med. 4:100-105.1975. 93. Stadel, B.V.: Dietary iodine and risk of : 74. Information for physicians on irradiation- breast, endometrial, and ovarian cancer. Lan- - related thyroid cancer. Report of Workshop on cet 1:890-891, 1976. the Late Effects of Irradiation to the Head and 94. Edihgton, G.M.: Dietary iodine and risk of-... Neck in Infancy and ^Childhood. CA 26:150- . breast, endometrial, and ovarian cancer. Lan- ' 159.1976. cet 2:1413-1414,1976. 75. Jablotr, S.; Belsky, J.L.; Thchikawa, K., 95. Williams, R.R.: Breast and thyroid cancer and. Steer, A;: Cancer in Japanese exposed as and malignant melanoma promoted by alcohol- children to atomic bombs. Lancet 1:927-932, induced pituitary secretion of prolactin, TSH and MSH. Lancet 1:996-999,1976. 0Q 1 '191 h CA-A CANCER JOURNAL FOR CUNICfANS ' United States Shipyards Irving J. SeiikoM, M.D. and E Cuyler Hammond, Sc.D. CLINICAL LATENCY OF for example, where individuals simply ASBESTOS-ASSOCIATED CANCER working near "asbestos workers'' are,ex posed to the same dusts. Risk extends even During the past 15 years the important disease potential of asbestos exposure has been clarified, The principal hazards have been demonstrated to be cancer of a num ber of sites; gnd asbestosis. Among asbes tos workers, approximately 20 percent of alj deaths are due to lung cancer, six per cent or seven percent to pleural and/or peritoneal mesqgielioma, and there is an to individuals not employed in gn asbes tos-contaminated environment:-mesothe lioma has been found ampng family con tacts of asbestps workers residing in the same households, as well as amqpg people living within a quarter of a raiie or so of asbestos plants or other facilities which . have; used asbestos-containing materials. Although mesothelioma is not neces- excess found in several other categories (e.g., cancer of the esophagus, stomach, colon-rectum, oropharynx, larynx, kid ney). Table 1 provides ananalysis ofcauses of death among 17,800 asbestos insula tion workers , in , the United States and Canada. followed prospectively from January 1,1967 to January 1,1977. < Risk of :asbestos-associated disease hasalso been observed in workers in other trades where asbestos exposure occurs-- (_sarUgr the most ccmimon disease-resut^hS . fromasbestw exposiije, it provides a very useful index of such problems, 'since it is only uncommonly seen as a result of^ex posure to other agents or without iden tified cause. Large scale investigations of ' .series of cases of mesothelioma in France, Great Britain, the Netherlands `-'and else where have demonstrated that the large majority of these cases can be traced to : prior asbestps exposure. For these neoplasms, as for all can cers due to asbestos exposure (and, in deed, for extensive asbestosis as well), a Dr. Selikoff is Professor of Medicine, and ; rather uniform characteristic has been CDirector, Environmental Sciences Laboratory, Mount Sinai School of Medicine, City Univer sity of New York, New York, New York. Dr: Hammond isVice President, Epidemiology found: the disease usually does not be come clinically evident for 15, 25, 35 or more years from onset of asbestos ex Cand Statistics, American Cancer Society, Inc., New York, New York. posure. The initial decades are periods of grace with no illness or disability. While This is a special report from the Environmental - some early X-ray changes may be seen Cancer - Research . Project,- American Cancer Society and the Environmental Sciences Lab after five to 15 years, they are limited in oratory of the Mount Sinai School of Medicine extent and not usually accompanied by ofthe City Univerfity of New York- significant symptoms.They merely dem- VOL 28, NO, 2 MARCH/APWL1978 sori Q)l7