Document G6aQn1myGjazwb2Z4ZjOVMRX7

FILE NAME Manville JMA DATE 1966 Dec 16 DOC JMA084 DOCUMENT DESCRIPTION Meeting Minutes - Asbestos Health Research J- M Confidential Memo ~ 4 eo AL 10260102160174670401638 AsbestosAsbestos ResearchersMMtg tee gMtg atat PHS 1966 wes hta e Ep tsys wa e ade ., . fn co del SARh E i An: dieolan thet ot # te De Anca ntimatanbendinds Alana ant ome arte J. FIDENTIAL MOMO FOR FILK Meeting on Asbestos Health Research Occupational Health Research and -------, RECEIRVEEDCEIVED --,--... Resasreb end Engineering Center December Engineering 1966 4 Training Facility C. SMITH SMITH 7110 411 259 Pulic 88 : U1.014S. BroaPdulwicayHeaClitnhciSnenravtiiceOhio JAN JAN 91967 December 1 , 1966 } LS & started the meeting by reiterating its purpose to find out what various : Dr. Brova the field of occupational bealth were doing in studying the potential workers in to arrive at any conclusions concerning f hazeris of asbestos The purpose uns pot the validity of data on this problem but merely to acquaint people with the scope unfortunately of each others setivities and to prevent duplication As noted later q used the meeting as a sounding board to review their many of the participants than to discuss programs in progress A list of the participants past work rather presenting 10 simute sumaries is appended Approximately fifteen others were there as invited auditors ; Dr. Levis # Cralley Palie Health Berrico Cincinnati Cincinnati veli na in the study appears retrospective history Cralley discussed the program in which 2500 people in each of k asbestos The industries were being compared with an equal cohort of mmuxposed people program vill sover approxiantely 25 years and include a retrospective histo1ry1as 4 a prospective futufr utue re Crallay's thought out and extremely complete and pointed samples used in almal tests way been boomme contaminated in preparation emphasized emphasized the importance of complete cercterization of all No subsequently trees metals radiation size sta ; material~ wood in asbestos research including Be pointed out that nickel and chrome have been piekod vp from grinding equipment ik As interesting side light who that pyrene is apparently broken down by niekol betion and this specific enzyme is destroyed by minute quiitities of estyme lainhart emphasised the problems of inctoermpmrietttienegorn aaylasssaifnidcaatsiodnidofoptohreurnscurbosniecqsuiesntly ' dq strongly recommendtehdeitrhattastkhesoprtehsaetntcurrent work in progress vill uniformly rapidly complete described by all vertere tresolita a statistical survey on 290 tale workers with at least 15 years Kleinfeld described workers entaide Sev York for the some 1940 - 1965 period ned m 150 sabertos found for both sets of vorkare exposure Dignificuat correlation between lung cancer was This vas more significant vith the individually as compared to population norm brackets for the tale and sabestos workers and only is the older age a Ye. workers Be reported on no current work or 8 ee ap Tere er emennaae ve me OAS 000605 VON 2186 eT ve ang ee mime ete 4 le oo paditathicetea hkl tlasinnte de avin nod dart. we es oe ie M. CONFIDENTIAL MONO FOR FILE -2- December 16 1966 j yen , : q Dr. Jan Lieben Pennsylvania State Occupational Health Director 1 Lieben presented a survey of past work plus current surveys in a small tova in operation where mesotheliom mesotheliom Pennsylvania probably Manhattan considerable hed been observed Many of the chees were consented to asbestos only by inference because of the proximity within several miles of the plant - a good case of incrimination by sasociation : Lieben recommended that a national register of meso.belim meso.belim ever be rs up to prevent prevent duplicate recording of the same canes in the literature and subsequent subsequent ecmpounding ecmpounding of cases during literature surveys Dr. 1. J. Belikoff Mount Sinai Kourital Belikoff reported much the work of his group and introduced them of Hammond epidemiology Smith animale Churg pathology Langer mineralogy Berkley technical surveys Schall industrial hygiene He described work which has already been reported plus continuous studies on the asbeston workers Three bospitals in New York do nov regularly take samples of lung tissue from all autopay cases examining for estestos bodies and fiber inclusione ce asked specimens will be correlated with pathologie information The date They are now starting as expanded progrua with 10,000 insulation workers It vill also include building trade workers indirect exposure neighborhood residents of a plant in 1942 geographic plus latent period for comparison of general populations They are beginning a progren to survey air pollution by looking for nineral fibers on air filter membranes They will study trace elements such as nickal iron chrome ecbelt and magnesium in vorhere langer has not yet defined make up of may subestos bodies by the aleroprobe studies are encouraging Finally smoking habits will be studied sad lthough reliko reiterated the strong effect of smoking even in the asbestos workers group Occupational Esolth Bureau was represented by The Bureau 1 checking chrysotile uines and mille end has found dunt concentrations generally high They were eritical of most management although Bone vere specifically Tuberakku indicated that the California Burneu has under way a study exposure 600 asbestos workers They will also check a large group that had a limited time exposure during large -time building operation Tabershaw stated that their investigation shoved large quantities of asbestos fibers being used in butaation of both power plant and in the ship building field He and Lieben vere extremly vritical of the AI nloppy installation procedures especially where trowellable cement emtaining sabestor was used He emphasised the large and intermittent intermittent But concentrations encountered during installation . oy AI . Oe oesee: OEY Be PR CRM BER TERRE + O Gm a re, 7 4 come - z. Mee * a Pde oh. cone a 335 24 fh Rin AE K. CONFIDENTIAL WENO FOR FILE -3- December 16 1966 Dr. B. Cuyler Hammond Rammond revieved the statistics und emphasized the importance of adequate sampling There appears to be a probable relationship between OI cancer and asbestos exposure No especially requested that various investigators pool their date so that it might be possible to obtain statistically significant data on a large basis as contructed to statistically significant date in each of a myriad of small investigations Smith described the progres now being started by the QAMA grup and introduced Dr. Corbett McDonald of Mc0111 University who is supervising the vork Smith briefly described Manvillu's positim and our interest in srriving at factually correct inforzation Be emphasized the use of anosite primrily in insulation and therefore by asbestos workers He pointed mut that Johns Manville did dave large population of workers who are continuously monitored and that employment and health records were available to the Public Health Bervice as a source for epidemiology study Dr. Baith noted the availability of standard samples of asbestos athersis from the Johannesburg Pneumoromiosis Research Unit Pe. H,, . Wolfeta Dalted States H^ber Wolfsie noted that 500 people in their Atlanta Georgia textile plant are being studied clinically Dr. C. C. Blackwell Jr. Americas - Blackwell spoke briefly on their cooperation with the Publie Realth Servies in studying degradation products from brake shoe material Practically no asbestos vas observed in the degradation products except under extremely h^'veree panietype stops This subject will be reported in a separate latter George Dr. V. Institute Sen~ ta quonsored . Orexpation sa4 Deel remmesta Vright reviewed ita fumesions and operation It emtojas representatives from government Labor and industry end has a scientific commision primarily medical doctors including Dr. Marvin Kupehner Paul Ketis and others including Dr. K. Pelaar vho is a time secretary Their purpose is to 1 develop information on bealth aspects of asbestos and other minerala on a retrievable beste 2 provide by industry with current information and 3 engender research others with no internal resourch To seremplish this Dr. Fulmar vill travel extensively visiting vorkers and hopefully pollinating research activities The Institute vill receive proposals and attempt to fund meritorious projecta ee a eet] a rms om r+ boas . 1 RPI f rere nme ageme Gemma mm wy MA ciel a nem chbttne Detalles ky a? ae . nile Bed . . valle Retention oo . eo ot se . Ondohc ot he e sbi - jn on bE! Ree ee MEHO FOR FILE A. CONFIDENTIAL oh. December 16 1966 Dr. Corbett McDonald Madill University McDonald revieved briefly the program at McGill to study rays of Canadian asbestos workers including both Manville personnel and Thetford ares personnel The program vill include histories of past employees and study the mining and milling groups as distinct populations Be emphasized the need for the pathological examination group to come up with a new and acceptable classification system for rays McGill's study vill start approximately March 1967 and they will adopt their own classification system if one has not been finally accepted by that time During discussion it was noted that the Thetford mines contain from 2 to 5 per cent Free silica while practically none has been noted at the Asbestos Quebes deposit Dr. Pedford Kettering Radford questioned whether rados content was being measured since this is known to be an extremely potent factor in bronchial cancer No radon has yet been observed in chrysotile deposits although some has been found th the crocidolite and amosite deposita probably due to the proximity of uranium to the latter Dr. Churg Mount Sinai Hospital Hospital a Churg emphasized the difficulty of recognizing mesothelioms and that classification vas not always unanimous He suggested that a panel be constituted to entse all doubtful rays to scure scaformity of diagnosis Dr. Paul Gross Groes is so smpleting a year study with three specion of animals exposed to inhalinait nhi alao tin on chambers He has attempted to get greater retention of dust by Lye treatment of the trachon but this was set successful He did obtain 14 per cent of primary tumors in rat~ bet nonin bansters or nice The suly other occurrences reported in rete by euch tests ben benn by Neguer in suly suly of tests The reason for this is unexplained possibly the type of in My heve been diffurae ndnbte responsible Cralley suggested that type milling technique may have added trass alloys to the fiber for emple Crailey found an Lacrosse in BI after grinding Groes has studied a variety of fibers to fateraine whether malmstor bodies are specianf d mi aye be related to the preseonf csaey izorquale fiber such as fibrous attapulgita glass fiber aluminum siliente fiber unidentified but probably kyani BLC fiber 464. ma mlavat allfeste sad the glass produced asbestos bodies attapwau s l notgdi efit nie te SIC produced protein severing but without iren celer All duste gure an inert dust reaction Be thought carcinogenicity sould be due to some added function and not necessarily ee to nagancium silinite Bynthetic chrypetile prepared at Kellee Instivtiaugt ire um intertsr adaprc obeh redena o fl ibl rosy is eae et 1 Qe tag oF Oe wmsny learned oer eaten jas yt i Saeacectmaaeaciasyntidlan? jpatine hnS it M binsit.all lin ain Ben st sk Nits ApEn aan snes ch a oy cine ade adi Amen ts M. CONFIDENTIAL ae gee MPO FOR FILE $e December 16 1966 Pp Ne bas suggested the possibility of getting a purer form of chrysotile by destroying any pyrene and ridding the chrysotile of trace materials by vento pyrene using aqua regia vould harm fiber or treating with o thelating agent The night be removed by heating the fibers above the decomposition temperature of pyrene He is planning to lood asbeston or apathetis chrysotile with trace materials auch ag Fe Ni Cr or NM and also check pyrene with or without fiber this would duplicate V. E. Smith's work He is exmaining the effect of specially prepared glass fiber dust approximately 1 mierou in diameter using a phenol formaldehyde or starch binder Orone suggested the name of FERRUOLIQUE body as a replacement for asbestos body since these forms are apparently caused by other types of fibers Te indiested the need for more study of the nature of the FERRUGINOUS body in wan and a studoyf the development of the FERRUGINOUS body both ia mea and animals He suggested Langer of Mount Sinai Hospital already has more work on isolating PERMISINXB bodies from people and using the microprofboer raised the study He Dr. A. such a prog unr dertva ay question of beryllimentant although he had not yet observed may la a feeding study of rata 6 per cent skrysotile we included in the food for 1 year with so resultant abnormities Gross requested from the writer specifie samples of fiber which will be reported later and suggested that we collaborate on a report after he has completed further work with a vider variety of specially prepared fibere Smith reported on his work which bus wirendy been covered in a pointed for file Asbestos Health Program Mount Bins Hospital November 9 1966 He poinoutt e thd at harsh fibert were apparently re desging the soft fibers and that benzo lus chrysatile more more dging them sgrene Dr. Kenneth furth emphasised that the use of harsh fibers vie almost insignifienst " compared to soft fibers Some of their moviedge of hard versus suft fibers som compared compared emphasise can be attributed to informatics from Bedellet Dr. Gelibeftried produred emphasise emphasise the importance of march fibers by noting that these might be produred during man of asbestos materials at high dehydration and that this material would temperature be released and emseguent during removal possible possible inmuiation There is a technical validfi ortty he inferean ndcDer. K. Quith oesr^b,yd mpansizing the low wonge of chrysotile in inondation materials Dr, Porte A, Mediral" Consen Ginrleston Beuth Carolina NcIver described past work with bongles wing staceyheres loaded with 190 millia portfeles per cubic foot derived from 197-1_chrysotile 197-1_chrysotile He acknowledged assistance of Marille is supplying materials Thay re currently investigating asbestos and virus with no positive resulta te date. . ome ete ay weg OV OEEY BATS Cree Pe oe Neeerer Toe eee Peassambenatil a> oa aliens Reh tion mM ome at Pa tm es ee . MIMO FOR FILE N. CONFIDENTIAL -60 December 16 1966 Dr. Sidney Speil Manville Johns Manville's Spail revieved projected program in studying surface characteristics of asbestos In addition the general program to study the decomposition products obtained during the installation and service life of a variety of products containing asbestos was described The fact that chrysotile is not indestructible was noted 4 12/23/66 This presentation is givm in more detail in a letter to Levis Cralley dated Dr. Arthur Langer Mrunt Sinai Hospital Langer reviewed his work currently in progress at Mount Sinai on asbestos bodies This who covered in more detail in my memo for Chrysotile in Asbestos Realth Studies November 3 1966 the analysis of file Synthetie Dr. Paul Cartier Cartier reviewed his work on the clinical studies of Thetford workers and commented on the availability of a large population of workers for both retrospective and prospective studios 1 Dr. Arthur_formli Arthur_formli hay~-nState University Vorvald described his experiment in which for the past few years be has been collecting particulates and analyzing gases by means of a large coalcal collector ove 6 street corner is Detroit During this year period 14,000 suble fest per minute , . of air has been collected Samples of this material have been examined by Juhan Manville { aInndclufdreadnkilny tihte imassh s no^pmaeatel hroie paes lles sOsuprrocbolmemmenttas d wilel tbeerr etphm oertiaemdn ouse netpasraadteltyypelaoffsihboerrt report In addition Torvald has been carrying on a rather extensive series of tests wing interpleural intraperitoneal and subcutaneous injections of four different specias of animals with three different types of fibers The resulta have shove considerable between the spesics of enimals and are not com differe difn fert ent Forvald pointed out the extreme poisonous charseturiatium of beryllium TH aiiligress per suble meter in the permissible limit however this taxie fusta bes alvays re- sulted in orth and not is say manereus resection. The second day una to be devoted to a critical summary and to planning bured of the info grer catem d ia n tht e pri evioo us n day This was led by Dr. Clark Doeger of Chiifornia Praskly this dineunion vaatered remarkably vith very little semblanc semblanc of an integrated program arising during the meeting Ropefully after all the data are rized by Dr. Cralley it may be possible to me the data presented during the first day na a basis for integrating or at least collating the work being 4000 at various agencies All participeats vere requested to send in a written summ of their presentations is so much or as little detail as they cared and to make any comments they wished to guide future research programs Dr. Gralley promised 84 OFF OE AEE OGES 8 SED Ie CERNE ENCED AREY . es er ane help tepetten te ba nfuenditipaPhdbatt A me eli ea M. CONFIDENCONFIDENT TIAL COINFIA DENTLIAL KIMO FOR FILE -T- December 16 1966 to distribute information to the participants It vas suggested that Health Service consider the desirability of holding such a conference about 2 years the Public again vithia A very large percentage of the time vas devoted to a review of former and nevly proposed classification schemes for classifying rays In general it seemed that a large percentage of the participants mecially the state public health officials had already in their own siads convicted asbestos Oa the other hand a reasonable number of participants especially those concerned with actual laboratory work were sincerely interested in selestifically sumaining the specific nature of the problem and to pla down the role of physical and biological parameters involved Dr. K. C. Brows the purpose of this meeting was to bring together researchers the various chemical sephasized again ibat Its purpoes vas mot to critically evaluate the results of past research and therefore he had no intention whatsoever at this time of releasing any report to the prese other than the fact that a group has not ta review research in progress This ma especially directed at one participant who recommended that the group go en record publicly soncerning a relationship between asbestos and lung ser I believe that the presence of Dr. X. Smith nad wyself at this morting helped to convince the participants that Janville is actively stud they proi bln em tgo anxious to resist towards a rapid sad conclusive mIREDILI actively the question whelber & an: public healt^ prublan dosa in fort exist Shad Speil oh 2 + NA Sem Geen memammins ' SUE Crier -abeg neue saat ca teed alii nediitien dab iel ny ad hls wth haha eee pwr i we he Baten vlna le a ) 4 oe ae, N. CONFIDENTIAL * : . MEMO FOR FILE Appendix 8- December 16 1966 Occupational Health Research and Training Facility ] U. 8. Public Health Service 1014 Broadway Cincinnati Ohio Agende for Asbestos Meeting Wednesday December 1 1966 9:00 .M Welcome Dr. MurraCy. Brown 9:15 a Presentation of scope and status of going research projects - the list of participants in still tentative others may be added Dr. Murray C. Brown Moderator Dr. Levis J. Cralley Dr. William 8. Leinhart Dr. Thomas 1. Kilby Dr. Morris Eleinfeld 3 Dr. W. L. Wilson Dr. Jan Lieben Dr. Irving J. Selikort Dr. Irving X. Tuberabav Dr. Thomas 7. Kancuso Kancuso Dr. B. Curler Rammond 4 Dy. Kambeth V. Both 4 Dr. C. C. Blackwell Jr. Dr. George W. Wright Dr. J. Gaurgs Dr. Paul Groet Dr. William 2. Buith r 4 q 4q Thursday December 8 1956 9:00 6.1 - 19:00 Discussion of further research noods Dr. V. Chark Cooper oderator 1:30 - 3:00 p.a. Review of definitive knowledge of health effects of exposure to asbestmo Dr. N. Clark Cooper | 3:00 3130 p O mmas7 . Dr. MurraCy. Brows PES Tt T ool 7 leaaien nel eteaee met w0 a OM 1 were ue mens se CEI oat REN ALE IT RUA Ne DR tS Nera ae AS rritae AL102601755 AL102601755 AL102601755 AL102601755 Peemarey 7 Pooterering Kovember 14 yale het SRN UPALCH PAROREE T N SS Deborntorien i 4 SID BTA TA { 1 Twirleigh Twirleigh Dickinson Dickinson Univeraity $ Health Reach Tab194 Tab194 t Mito H. J. xeri P. } Miller Miller Pa of Fezlth els Perena of laboratories laboratories er Washington D. C. a enmre Tubite Merlth Surview Cn Impt of Health rducation & Melfore Melfore eat Division of Confpational Confpational Cincinnati Ohio Health V. H. hepris 1. K. J. Chulley A Public Heelth Service Service ee Department Department of Pekith Edera Irm & Welfare Welfare ARN Division of Cocupational CocupationaCoclupational Health Ae 3rd C. Ata S.W. Piter Net Washington D.C. 20201 Polla Health Bervice tare D. of Enolth heation & Welfare C. Pompey Chil 11. I. Etv Etv Sawtenstal Cancer Bection men Hitional Cenear Instituts Instituts Bethesda Md 20014 eo ,Vi Mount dinal Koryital 1 8441 10 01 New York B. Y. 10029 - 111pt Gormley Chory Yule Daivarsity School of Redfeina Napt of ASATORY 310 Cedar St. ce Now Ixven Conzastleut Conzastleut Ee se tt Amarizen Cancer oa s ry e - P. are oho Resinte Fig ae Tene, fe Rretiyt ) Panech Panech Meta 12. 12. 81 Nax York 7. I. 10017 10017 Goyder rr ron Heessetvwatte Teale Sule 68 Probe lace Maeirnd th rere mcupational Czby14 37 Baleal ... Barvica 4005 2817 281728172817 ame ae pee, ere Name Same 2 ee Pe , . Seven fae? : 2 4 Seah. al aeBa bea e toa rn N te. ' Nyy . we t wn Ain id ws . ~ ace Ne ay me Oe Dy ne Be dhe! wk: et an oe of . -3 NOV 16 1966 Laboratories Wingfaity Wingfaity Tumor Citave Registry d Dept. of Pathology Ottava Canada Pereconel Phareftsz) McGill University Dept. of Spidemiology & Health 1033 Pine Ave. West Montreal 2 P.Q. Q.4 i National Cancer Institute of Canada 790 Day St. Toronto 2 Ontario Canada J. C. McDonald } j A. J. Phillips 4 Quebec Asbestos Manufacturers Assoc Comupational Health Advisory Group Quebec Corrubent Occupational Health Advisory Group La be formed Deyt of Vines and Technical Fon Metallics Division 4 India St. Ottawa 1 Ontario Canada Surveys E. M. Woodroofe GREAT BRITAIN AND IRELAND Asbestosis Research Counsell 4 University of Curbridge Cambridge England } J. M. G. DETR Asbestosis Research Committee London En W. J. Smither . . , a4 "4 Queens University Buy at Thereupeuties and Pharmacology Belfast Forthern Ireland Medical Research Comme Pasmoronicsis Research Unit Llandough Hospital Penarth Glasorgas Welas Walab Rational Behool of Medicine Cardiff Wales P. C. Elme C. L Voda J. C. Vagner J. C. 6114CS J. V. Mi~ mora V. Timbrell Ministry of Labour a London V. D. Buahansa . .. ' Chester Beatty Research Instituta Isstitute of Cancer Research Royal Ceneer Rospital Palhas Pond Londra S.V. 3 Ragland 3. 9 Barington F. J. C. Ros R. Beyland Beyland : t Se CRE oo toa FT ce CL A Ie rmpeerarnactgn ade Ts , Ren eae oweAE ar aotFae ary oe oA a eat eR Oh ld aa ee Ale tee on inte ela wear) 2dt onal mane aaroy . POOR meme ees oes \ ogo \ \ St ao At fe! \ oecparene! i cy ie he mle eee oe BU cee eee ae en me a ee aes dU ee Mab cad Bea cee tee ke We Wate -: : . H } , . i K45 aa we-rt:mo oe mes ee AN eles Acces.ae ee eat Tir Se ityaonmers Anahi ponent ae eT cen SRC oe sperane e ay ate wet caentortneins as eee tate dee Ub Laboratories London Rospital Medical Dept. of Pathology Whitechapel Rd London England School Paiversity of Reading Radira England Trinity Collage Dept. of Pathology Dublin Ireland Ministry of Pensions London England and Retional Insurance Enfety in Pines Research Establis Sheffield England The Royal Featson Mespital Cancer Research Dept. Bill St. Glasgow Bootland Leadon School of Pygiene ^ Tropical Medicine Dept. of Docupational Health & Applied Physiology University of St. Quenna Collegn Dundes Scotland Andrews Personnel D. C'B Marien P. Holt J. Milla D. I. Young M. T. E. Medanghey J. Vittie 0. Negelschuldt R. P. Penedek A. Peacock M. L. Nevhouse R. Whe00 A. Ronch C. R. Rell ITALY Clinico VOTO Dept. of Immology Via St. Barnabea Milan Italy University of Turis Institute of Pathology B. Parais C. Vigliari 6. Hottura BOUTH AFRICA Presocontouis Presocontouis Radical Duress Deforte St. Johannesburg bouth Africa 0. K. Crwar University of Cape Town Dept. of Pathology Cape Town South Africa Medieal Behoel O. Thomson Comell for ScientiMe & Industrial kassarch 1. Vabatar Prevutontosis Research Unit ?. 6. Not 1038 Johannesburg South Afri rmereee 7+ hoe Tm eee ee mee ct comet ge ee * Laboratories AUSTRALIA Department of Public 57 Murray St. Perth Australia Realth FINLAND Tampere Central Hospital | Tampere Finland Institute of Occupational Fealth Heartmaninkatu 1 Belsinki Finland FRANICE University of t-on Chaire de Phors'opathologie das Voles Respiratoires NOV 16 2956 Personnel Kiviluoto L. A. T. Recio P. Caley University of Munich Institute of Pathology Erazberbans Leninatiass Leninatiass Stadt Germe Democratic Republic and the Erhebungstelle of the German Central Institute of Occupational Dreadon German Democratic Republie Health . University of Kial V. DontenvilDontlenvil 0. Jacob N. Auspech B. Klein 11/13/66 Ts TOR a = ~~ ae em ae rarer meyer eee remem : . cM Le Dale ale bE Raa ise be nel, te teat tle ose ute Laboratories University of Kansas Medical Center School of Medicine Dept. of Pathology & Oncology Kansas City 3 Kansas U. 8. Dept. of the Interior Bureau of Kines University of Michigan Dept. of Pathology Ann Arbor Michigan ^ University of Pittsburgh Graduate School of Dept. of Occupational Health Pittsburgh Pa Council for Tobacco Research New York ; Chicago Mediem Seboal Institute for Medical Research Division of Cncology Chicago Ill Jefferson Medical Collage Institute for Clinical Science Philadelphia Pa Glass Fiber Mfg Pro yT. P. Kanenso W. Poal B. C. Bockett U. Saffietti F. Cafis P. Smbik F. V. Bunlar~-n Hello Institute Pittsburgh P. Thetford Im ustrialkista Thetford Nincs Quebec Canada Kinistry of Health and Welfare Occupational Health Divisim Ottave Canada Secre Coeur Hospital Montreal Quebec Canada A. J. devilliers Director Biological Unit Chief - ow of Pathology