Document G6Nyyg2zZyd36zV7D3zokEoeq

SANITIZED REPORT M1K R 36a7a0y4). EXPLORATORY 26-DAY GRAL TOXICITY STUDY wim TELOMER ALCOHOL, TELOMER ACRYLATE, PFHS AND PFOS (positive control) BY DATLY GAVAGE we RAT FOLLOWED BY A 14/28-DAY RECOVERY PERIOD NOITOXToSrutbsNtoarncTe7s0N2`O80T5,4O8X4T,P-7r50o02f84o5,c3t,T27640322550233,8, 18-4043526,an1d-682491541 <page 1 of 451 - rg ZED ret SANITIZEL 000002 TELOMER ALCOHOL/TELOMER ACRYLATE/ REPORT APPROVAL PFHS/PFOS NOTOX Project 242933 ISrt.udyS.CD.iMr.ectdoerHoog . DMrasn.agWem.eJn.tAM. Frieling lees Date: @% Opell 1999 Abdhe.li2na ows: 28 Qpnid 919 Pogo 2 - 000003 TELOVER ALCCHOL/TELOWER ACRYLATE/TM PFHS/PFOS CONTENTS REPORT APPROVAL SUMMARY PREFACE STUDY PLAN MATERIALS AND METHODS TTeesstt SSuubbssttaanncceesFormulation ; GPuuirdpeolsieneasnd Rationale Archiving AlTlesotcaStyisotnen . TrAeniantamlenHtusbandry ROebcsoevrevartyions CMloirntiaclailtySi/gnVsiability FBoooddyCWoenisguhmtpst fon ClinVaitcearl. LCoanbsournapttorfyonInvestigations HCaleimnaitcoallogByiochemistry PathUorlinoaglyysis NOercgraonpWseyights HiLsitvoertecSahmnpollionggy StHaitsitstoipcaatlhoAlnoaglyysts RESULTS ObseMrovrattailointsy X Clinical signs NOTOX Project 242933 2 5 7 8 9 190 11 1a2 1132 1133 11 114 1144 115 1176 1177 1188 1198 1 2 2200 2 - Page 3 - 000004 TELOMER ALCOHOL/TELOMER ACRYLATE! PFHS/PFOS NOTOX Project 242933 RESULTS (continued) 21 BFoodoyd WCeoingshutmption 2a Clinical Laboratory Investigations 22 PatHChMolaalieconmrgiaoyctsaoclloopgtSyclocEhxeanmtisntartyion 222% 2 DisOMcriugsarsnioosHnceoipaginhcdtEsCxoannctlnuastiioonn 22 FIGURES 2 BBFoooddoyyd CWWoeeniisgguhhmttpstGafionn 2a382-.a2398 Relative Food Consumption 34-35 TABLESCl- iSnUiMcIaRYSigDnAsTA Body Welghte 7-360 eles RBFeooeoddytWCveoelngshuFntopotdGafiConnonsumption 6&.872 78.76 HCGlarisannniactaNoleliogBghiytosc-hOerngtasnt/rByody Weight Ratios 0971.711.801802 BiHoicshtoermiicsatlrydata Haematology / Clinical 113-118 TABLESMCol- ritnIaiNlcDiaItlVyIDSUiAgnLs,DATDaAtly Body Weights 1112250631-.-11911256520 :. BFRoeoolddatWiCeavinegsuhFrtopsotdGfCaaoinnnsumpt fon 116619-.116782 175184 KCeiylnitcoalMisBslioncghenViasltureys and Remarks Haematology / 165 HMaCOaerlcgimrananoitcsoacWlloeopfgigBychltoscF-hiOenardtgisantngr/syBody Weight Ratios 21285968.-.222828711 282-305 APPENDIX 1 Pathology Report 1-146 LAST PAGE OF REPORT 51 <Pagye 4 000005 TELOMER ALCOHOL/TELOMER ACRYLATE] = PFHSIPFOS NOTOX Project 242933 SUMARY ExploraPtFoHrSyan2d8-dPaFyOSor(aplostiotxiivceitcyontsrtould)y bwyithdaTielylongearvaAglecofhnolt,heTerlaotmefrollAocwreyldatbey,a 14/28-day recovery period. D(oVseehicTleevelCsontfroorl)t,his3 s(tPuFdOyS,], pr1o0vi(dPeFdHS)byantdhe30spmongs/okrg, bwoedryewesieglhetc/tdeadyto(Tbeela0mer Alcohol, Teloner Acrylate ). T-heEECstDuidyrecwtasiveba9se6d/4o/nEEtCh,e fB.o7lloRweipneagtegduidDeolsiene(s2:8 days) Toxicity (oral), 159. - OECD 407, Repeated Dose 28-day Oral Toxicity Study in Rodents, 1995 Tahdenintiesstterseudbstdaanicley, ffororamtulalteeadst in281%dayasqueboyusoraclarbgoaxvyamgeethtyolSPcFe-llburleodseS,prwaagsue Dcaownlsiesytirnagts.ofOn8emavleehsiclaendc6onftermoallegsr.ouApnanedxtrfaive3 atnrienaatlesd pgerroupssexwepreer tgersotuepd,wereeach a2l8lodawyesd o1f4 rdaeycsoveorfy.recovery and another 3 animals per sex per group were allowed oTrheonfcoellodwailnyg p(arreacmoveetreyr)s;webroedyewveailguhattedt:wiccelinwiecekally;sigfnosodtwciocnesumdpatiiloyn (wtereekaltym;ent) mclaicnriocsaclopypatatholtoegryminaafttieorn;4 woeregkasn waenidghattstheendenhdisotofpabtohtohlorgeycovonerya speerlieocdtsi;on of tissues. RESULTS T(e3l0onmegrlkgAlldcaoyh)ol: 1. Tdoetcarleasperdote(idn), agflteorbultirneatamnedntt.otaTlotaclholpersotteerionlwwaesrestill 2. Mdiedczroenaasle/dcoanfttre{rlo2bualnadr4hwyepeekrstrorpehcyovwearsy o(b3)s.erved in the pTainvecrr,easand(4)exoacftreirnetraepaotpmteonstis/asndinghlaed cpealrltianlelcyrosoris in the completely resolved after 4 weeks recovery. T(e3l0ommegr/kgA/cdrayyl)ate: 21.. BTootdaylwepirogthetisn,wergelodbeulcirneasaendd attotatlhecheonldesotfertorleawtemrenet (3) d(e9)creaafsteedr t(r)eatamnedntalbunin/globulin ratios were increased (30 mg/kg/day) 1. Taocttailvitpyrot(ei)n,andglopbruoltihnr,ombaisnparttinaete(e3)ntwneorterendsefcerreaasseed and _ atlrbeuartnienn/tg.lobPurloitnhrormabtiinostwienerewaisncsrteialsledde(c)reaasfetderafter 2 weeks recovery (2). - Page 5 - 000006 TELOMER ALCOHOL/TELOVER ACRYLATE/ = PFHSIPFOS NOTOX Project 242933 P(1H0S:ngrkglday) PF(O3Sm:g/kg/day) 1. tTortiagllyccehroildeesst,eroalspa(rtaatned a$)m,inottotraalnsfperroatesien,actgilovbiutlyin(,) and palrboutnhirno/mgblionbutlifnne r(atiaonsd a$)ndwearlekaldeicnreeapsheods;phatase activity wsetrie11 idnecrceraesaesded(a)ftearfte2rweterkeastnreencto.verPyrot(h4)r.ombin tine was 23.. LMiivdezronawle/icgehnttsriwleorbeulianrcrehayspeedrtraofptheyr twarseatombesnertve(d).in the aTfitveerr 4()weeakftserrectorveeartym.ent and had completely resolved 1. dBoudryingweitgrhetastmeanntd afnododrceocnovseurmypti(o)n.were decreased 2. Ttortiagllycperroitdeeisn,, agslpoaburltiant,e taontfanlotrcahnoslefsetrearsoel,activity () end prartoitohsrownebrien tiinncerea(s4e)dwe(r)e daefctreerasterde;atmaelnbtumin/globulin 3. wAeurteopsiyncbroedaysedweiagfhttesr wterreeatmdeenctreaasneddre(c4)o.verLyive(r wanedigh9)t.s 4. MTiidvzeorna(l/caenndtr){1oabfutlerarthryepaetrnternotphayndwarsemaoibnseedrveidn einvidtehnece anong males after recovery. Fcroonntrtohecroemspuolutnsd PprOeSsendtoesded iant t3hismg/rkegp/odraty iwtascaninbdeeedconthceludceodmpotuhnadt the positive with the most sbturikTienssg sanedverpeeresfifsetcetnst easffeFcEtUsS, imnacilnudleydfPn HtShe(1l0ivesrp.ikCaodmapyo)undasndwTitEhLOWcEoRmpaArLaCbOlHeOL D(e3s0pintg/ekgs/ldiagyh)t.ly reduced body weights in females (TELOMER ACRYLATE only) end sone pse1r1ghdtaycdhiedngensotirnestuhletblionodcleaafrtersysttreenaitcmentto,xic3i0tymg/akngd ToErLgOaMnERdyAsCfuRnYcLtAiToEnorat macroscopic or microscopic level. - Page 6 - 000007 TELOMER ALCOHOL/TELOMER ACRYLATE; ~ PREFACE PFHS/PFOS NOTOX Project 242933 Sponsor Study Monitor !| Invoten Contact Testing Facility RsitsutdoypaDtinraatcotgoyr Si Canter, Bldg 220-802 3M Toxicology Services St. Paul, MN 55144-1000 Usa Marvin T. Case, DVM, PhD 3M Toxicology Services TS3EeM.iaCegPnhotouetnre,in(B65l313d)g0:45272-012-0320-E01-8002 SBFaHarxbFarroacuroetn(ee6an5nt1)o-pe7r3a3t-f1a7n7s3 TS3EeM.iaCegPnhatoenurs, (B6l5S1dh)g:a2d72:2401--o100N7n-6084 Fax (651) 733-1799 HNOaTnOsXaBk.oVn.watnagr 3 . TheNether ance 5231 DD 's-Hertogenbosch oIrr.. 3SCH.. WdoisHeorog Fpaage as 7- 000008 TELOMER ALCOHOL/TELOMER ACRYLATE/ = PFHSIPFOS NOTOX Project 242933 STUDY PLAN Start of Treatment 0086 OOccttoobbeerr 11999988 ((fmeamlaelse)s) Start Recovery 0064 NNoovveemmbbeerr 11999988 ((mfaelmeasl)es) Blood sampling 0034 NNoovveennbbeerr 11999988 ((MMaaiinn ganrdoupRse,covmearleys)groups 1 and 2, males) 0056 NNoovveennbbeerr 1199998 ((MMaaiinn ganrdoupRse,covfeermyalegsr)oups 1 and 2, females) 1280 NNoovveennbbeerr 11999988 ((RReeccoovveerryy ggrroouuppss 11,, fmaelmeasl)es) 0024 DDeecceemmbbeerr' 11999988 ((RReeccoovveerryy ggrroouuppss 22,, mfaelmeasl)es) Urine collection prdaeydo7se :+ 1291--3102 OScetpotbeemrber19918998 ((RReeccoovveerryy ggrroouuppss 11 aanndd 22,) males) ddaayy 714 :: 1138.-1149 OOccttoobbeerr 11999988 ((RReeccoovveerryy ggrroouuppss 11 aanndd 22,, fmaelmeasl)es) ednady o1f4 treatment :: 0230--0241 NOocvteombbeerr11999988 ((RReeccoovveerryy ggrroouuppss 11 aanndd 22,, fmaelmeasl)es) eenndd ooff trreecaotvmeernyt :: 0157--0168 NNoovveemmbbeerr 11999988 ((RReeccoovveerryy ggrroouuppss 11, anmdale2,s)females) eenndd ooff rreeccoovveerryy :: 1091--2002 NDoevceemmbbeerr 11999988 ((RReeccoovveerryy ggrroouuppss 21,, fmaelmeasl)es) end of recovery : 03-04 December 1998 (Recovery groups 2, females) Necropsy 0043 NNoovveennbbeerr 11999988 ((MMaaiinn ggrroouuppss,, mmaalleess)) 0056 NNoovveemnbbeerr 11999988. ((MMaaiinn ggrroouuppss,, ffeemmaalleess)) 2108 NNoovveenmbbeerr 11999988 ((RReeccoovveerryy ggrroouuppss 11,, mfaelmeasl)es) _ 0024 DDeecceemmbbeerr 11999988 ((RReeccoovveerryy ggrroouuppss 22,, fmaelmeasl)es) - Page 8 - 000009 - TELOMER ALCOHOL/TELOVER ACRYLATE/ = PFHSIPFOS NOTOX Project 242933 MATERIALS AND METHODS TEST SUBSTANCES aThveatlsapbolnesorinfisormraetsipoonnsiobnlechfaorractteherisctoincpsletoefnctshse otfestallsutbessttancseubwsetraencetakdeatna.intAoll waictcho/umnitghbtefaofrfeectthetshetarptrocoefedtihnegsotfudytheinstourddye.r to determine if they conflict NOTOX SUBSTANCE 83484 DIedsecnrtiipftiicoantion BPuarticthy STteasbtilsiutbystaunncdeerstsotroaraggee coEnxpdiirtyiodnaste SSpteacbiifliictyGrianvivtenyicle TPEaLlOeMEtRo AnLeCdOfHuOnLtan waxy soltd 7No-t70i2ndicated by sponsor; treated as 100% pure At-roon temperature in the dark s0t7abSleeptenber 2000 11.%7aqueous carboxymethyl cellulose: not indicated . NOTOX SUBSTANCE 83493 DeIsdcenrtiipftiicoantion PBuarticthy STetsatbilsiutbystaunncdeer ssttoorraaggee coEnxpdiirtyiodnaste Desntsabiitliyty fn vehtcle TYeElLlOoEwR1AiCqRuiYdLATE 7No.t702i4ndicated by sponsor; treated as 100% pure At room temperature protected from 11ght s07tabSleeptember 2008 1Ap%praoqxu.eou1s.6caglrabdoxymaetth5y0l Ccellulose: not indicated NOTOX SUBSTANCE 83502 DeIscdriipeftfienoantfton White powder BPuarticthy 7No.t702i2ndicated by sponsor; treated as 100% pure sTetsatbilsiutbystaunncdeerstsotroargagee At roon temperature in the dark coEnxpdiirtyiodnaste S07tabSleeptember 2000 _ stability in vehicle 1% aqueaus carboxymethyl cellulose: not indicated - Page 9 - 000010 = TELOMER ALCOHOL/TELOVER ACRYLATE/TM PFHSIPFOS NOTOX Project 242933 NOTOX SUBSTANCE 8445618 : DeIsdcenrtiipftiicoantion PorfHfS-white crystalline solid PBuarticthy 1No-t70i2ndicated by sponsor; treated as 100% pure TSteasbtilsiutbystaunncdeerstsotroaraggee At room temperature in the dark Ecxopnidriytiodnaste s25taSveeptember 2000 Stability fn venicle 1% aqueous carboxynethy] cellulose: not indicated NOTOX SUBSTANCE 84141 DIedsecnrtiipftfieoatnion BaPturcihty TSetsatbilsiutbystaunncdeerssttoroargaege cExopnidriytiodnaste Stabfitty in vehicle pWhriotse solid TN-o6t29I5ndicated by sponsor; treated as 100% pure At room temperature in the dark s0t7abSleeptember 2000 1% aqueous carboxymethyl cellulose: not indicated VReantticolneale for vehicle Stability in vehicle B1a%seadqueonoustricaalrbfooxryrmeutlhayt]ioncsellpuelrofsoermed at NOTOX Sstpaobnsiolrity over 4 hours will be determined by the TEST SUBSTANCE FORMULATION Method Fhoorurmsulaptriioornsto(wd/ow)sinwge.reNopreapdajruesdtmednatilywaswitmhaidne 4for specific gravity of the test substance. Storage conditions At ambient temperature No chemfcal analysis of dose preparations was performed. - Page 10 - 000011 . TELOMER ALCOHOL/TELOMER ACRYLATE/~ PURPOSE AND RATIOWLE PFHS/PFOS NOTOX Project 242933 TThhee nTaetluarteiveandorpaurpFoosxeiciotfythiinsraetxeplfoorlaltoowriyngstuadryalwa(sgasttoridc.etseervmaignee)anbdasecsompare administered daily over 28 days and identify developmental compounds of lesser toxicity for commercial development. This study should provide part of a rational basis for toxicological risk assessment in man. The oral route was selected as it is a possible route of human exposure during manufacture, handling or use of the test substance. cutoeLnEs ETthheicparlatCocoom1itwtaeseroefvieNnOeTdOXanads argerqeueidredbybythethAertDiuctlceh A1c4t-.fuonncAtnfiomnaalry and the Experimentation. TGhueidesltiundeys:procedures described in this report were based on the following 2) OECD Gutdenine for Testing of Chemfcale, Guideline 407: "Repeated Dose 26-day 1) EC Directive 96/54/EEC, Annex IV.D, replacing EEC Directive 67/548/EEC, Part B : Methods for the Determination of Toxicity and other Health Effects; B.7: "Repeated Dose (28 days) Toxicity (oral)*. Official Journal of the European Communities No. L248, September 1996. Oral Toxicity Study in Rodents*, Paris Cedex, 27 July 1995 The protocol, study procedures and the report were not inspected by the NOTOX Quality Assurance Unit. ArcvING pNNroOo'TtdOaaXctoaBT..Vw.i,1a1wwibledlatweia,trhcdhrrieavpweonrttheaintdhfooulatlllowtihsnepgescpdioanntesanosfro'rs at least 10 years: written consent. Bae 000012 = TELOMER ALCOHOL/TELOVER ACRYLATE/TM PFHSIPFOS NOTOX Project 242933 TEST SYSTEM Test Systen Age at Start of Treatment Nunber of anfmals Randontsation Identification RSepcroaggnuieseDdawlbyeyirnatternCart1i:oCnDalBRgu(ioduetblriende,s aSsPF-tQheuality) rFeemcaolmeesndweedretensutllispyasrtoeuns(ea.ngd.noEPnA-,preFgDnA,antO.ECD, EEC). Source : Charles River, Sulzfeld, Germany Approxinately 6 weeks. 84 males, 84 females AgteneTreaastted5 rdaanydsonbeaflogroeritshtundyacsctoarrdti,ngbytocboompduytermweeaing.htA, whietahlthal]inasnpiemcatilosnwwiatshinpe=rfo2r0m%edofprtihoersetxo aconnnnaelnscenveenrte oinf atregaotomdensttatteo oefnshueraeltthh.at the Earnark and tattoo ALLOCATION rIdoeunptification TeSusbtstance NMaulmebser offenaanlneasls Amnailneasl nfuemmbaelress 11 MRaeicnovegrryoupgroup 1 VVeehhiiccllee ccoonnttrrooll 38 83 91.181 10957--110074) 21 MRaeicnovegrryoupgroup 2 TVeelhoincelre Aclocnothrooll 83 83 71-82145 110193.-111210 22 RReeccoovveerryy ggrroouupp 21 TTeelloomneerr AAllccoohhooll 33 33 2295-.3217 112215--112287)) 33 RMaeicnovegrryoupgroup 1 TTeelloonneerr AAccrryyllaattee 38 38 4313--4430 113279--113396)] 34 MRaeicnovegrryoupgroup 2 Telomer Acrylate 38 38 4459-.5467 114451--115423] 44 RReeccoovveerryy ggrroouupp 21 33 33 5671--6539 115537--115559, 55 RMeacionvegrryoupgroup 1 PPFHHSS 83 38 6753..7725 116619--116781,) 56 bRaeicnovegrryoupgroup 2 PPFFHOSS (positive control) 38 38 7871--7898 117737--117854)) _ 66 RReeccoovveerryy ggrroouupp 21 P_PFFOOSS ((ppoossiittiivvee ccoonnttrrooll)) 33 33 8993--9915 118859--118971) 8T3e4s9t3)suabnsdtances T(esluobmsetranAcleco8h3o5l02)(swuebrsetatnecsete8d348a4t),a dToesleomelreveAlcryolfat3e0 m(gs/ukbgstbaondcye veight/day. PPFFOHSS ((ssuubbssttaannccee 8844415461)) wwaass tteesstteedd aatt aa ddoossee lleevveell ooff 310mmg/gk/gkgbobdoydywewiegihgth/td/adya.y. - Page 12 . 000013 = TELOMER ALCOHOL/TELOMER ACRYLATE/ = "PFHS/PFOS NOTOX Project 242933 ANIMAL HUSBANDRY ACofnrd-ictainodnistfoned room with approxinately 15 afr changes per hour and the oenfvi2r1onCmeanntd acornetlraoltlievde whiutmhidiopttyinoafl50c%o.ndiLtiigohntsingconwasside1r2edhouarssbeairntgifiacitaelmperature Fclounodrietsicoennstoc1c1ugrhrteda,ndbu1t2 wheoruerscodnarskideprereddanoyt.. tDoevihaavteionasffefcrtoendthsetsuedyopitntfengalrity. GArcocuopmhnoousdfiaontng of 3-4 animals per sex per cage fn stainless steel suspended cages owifthtrweiartemenmteshunfdleororlsa.boArcactloirnyatciosnadtitiioonnsperiod was at least 5 days before start FDrieeet BVBA, aOcuceds-sTurtnohosutta,ndaBerldgipueml)l.eteEdachlabbaotrcahtor1ys aennianlaylseddifetor (nfurtornieCnatrfsi]andQuality contaminants are analysed on a regular basis. Results are examined and archived. VFarteeeraccess to tap-water. Certificates of analysts (performed quarterly) were examined and archived. TREATHENT Method Frequency ; Dose volune Dose evel - FOroarlnulgaatvaigoen,s wuesriengpalacsetdainonlesasmasgteneelticstosmtaicrhrertube, during dosing sOanmcee tdianielyefaocrh daaty,le7astday2s8 pdaeyrs,weeskp.prMoaxiinnagtreoluypthe aninals were dosed up to the day prior to necropsy w5ceaimlgleh/utkl:gatebdodwyeawekilgyhta.ccoArcdtuianlg tdoosethevolluamteesstwebroedy GGrroouupp 21:: 900mgmg//kkgg, bbo.ww..//ddaayy ((TVeelhoimcelre AClocnathrooll)) Group 3: 30 ma/kg b.w./dey (Teloner Acrylate) GGGrrrooouuuppp 465::: 31003 mmmgag///kkkggg bbb..www/..d//ddaaayyy (((PPFFOHSS,)) positive control) = RECOVERY Duration RReeccoovveerryy ggrroouupp 21:: aatt lleeaasstt 218 ddaayyss - page 13 - 000014 -- TELOMER ALCOHOL/TELOVER ACRYLATE/ = PFHS/PFOS NOTOX Project 242983 OBSERVATIONS Mortality / Viability Twice daily. Clinical signs i Daubrsienrgvattfheonstrweeartemennatdepertiwoicdededtaaiilyledin callilnicaanlinals: aanpcperoxiimneadtiealtyel4yhaofutresradftoesringdosainndg.anDcuering the preercfoovremreyd.peTrhieodtoinnleyofoneonsoebts,ervdaetgiroene apnedr ddauyrawtaison wAeTresryencpotrodnesd.were recorded and graded according to FMiaxxeidnunscaglreasd:e 4: grading slight (1) to very severe M(a4x).imum grade 3: grading slight (1) to severe (3). Mexinun grade 1: presence is scared (1). Body weights 2T5reaatnnden2t8.pertod : on days 1, 5, 8, 12, 15, 19, 22, 2R5ecoavnedry28.perfod : on days 1, 5, 8, 12, 14, 19, 22, Food consumption Weekly. Water consumption Sstuubdjye,ctibvuet anopprqauiasnatlitwaatsivemaiinntvaeisnteidgatdiuorningintthreoduced as no effect was suspected. CLINICAL LABORATORY INVESTIGATIONS B9l.o30oda.sna.mpliemsmewdeiraetelcyollpreicotredtounpdoesrt Tmiogrhttenetheexramiannaateistohnesftoar,Mabientweaennd 7R.e3c0ovearnyd pgerroiuopd.aniTmhaelsa,ninanadlsfowrereRecfoavsetreyd ogrvoeurpnigahntima(lwsithalsaomaatxitmhuen eonfd20ofhtohures)trbeeaftomreent oblroboidtalsamspilniunsg,ofbuatllvMaatienr vaansd Rperocvoivdeerdy. rBaltoso/dsexs/agmrpolueps waenrdecodlrlaewcntefdrominttoheturbeetrsopcrleoptatriendg tweistthsED(T1A.0fomr)haanedmatuonltorgeiactaeld tpuabreasmetfeorrscl(i0n.i5camll),biwoicthhenicsittrryateparfoarmeters a(n>d2.0132m1)a. `sFercoonndaEniDnTaAl-sanmupmlbeerswas17-c2o0l,lec3t3e-3d6,aft4e9r-524,we6e5k-s6,8, d6u1e-8t3o, i1n1e3x,pl1i1c5a,ble131 clotting of the first sample. - Page 14 -. 000015 "= TELOMER ALCOHOL/TELOMER ACRYLATE/ ~ PFHS/PFOS NOTOX Project 242933 HAEMATOLOGY TEhDeTAfoalsloanwinagntih-aceomaagtuollaongty, puasrianmgetetrhse wienrsetrduemteenrtmsin1eidstefdr:om blood prepared with Parameter Abbrevfat fon unt Instrunentfaotn Erythrocyte count/RBC m Sysmex K-1000 Haenoglobin/HB mol/l Sysmex K-1000 Haematocr 1t/HCT n Sysmex K-1000 Mean corpuscular volune/MCY 1 Sysmex K-1000 Mheaaenmogcloarbpiuns/cMulCaHr fool Sysmex K-1000 coMnecaenntcroarpufsocnu/lHaCrHChaemoglobin mol/l Sysmex K-1000 Platelet count an Sysnex K-1000 WRieGdthc/elRlOHdistribution % Sysmex K-1000 Total leucocyte count/MBC G/1 Sysmex K-1000 cDoiufnfterSeEnGtia(lNeuTteruocpohciyltse) 1(re1) Manual (Microscope) j E(OBas(oEpohsiilnso)p,hilLsY)M,PHBASO (Lymphocytes), MONO (Monocytes) Tchietraftoelloaswinagn ahnateim-actooalgouglyanpta,ranuestinegrsthweereindsettreurmemnitnsedlfirstaemd:blood prepared with Paraneter Abbreviation unit Instrunentation/Method Prothrombin tine/PT sec . tPianretiPaT)Tthronboplastin sec Sysmex CA-5000 Sysmex CA-5000 - Page 15 - 000016 "= TELOMER ALCOHOL/TELOMER ACRYLATE/ ~ PFHS/PFOS NOTOX Project 242933 CLINICAL BIOCHEMISTRY Tshaemplfeosllouwsiinngg ctlhieniicnasltrubmieoncthsent1sitsrtyedparameters were deternined fron serun Paraneter Abbreviation Unit Instrumentation Alanine aninotransferase/ pkat/l (ALAT/GPT) Aspartate antnotransferasel kat/1 (ASATIGOT) BBiIlLtIrTu.bin, total/ mol CCHhOoLlEeSsTt.eroTl., total/ mmol) Epos selective analyser 5060 (Eppendorf) Epos selective analyser 5060 (Eppendorf) E(pEopspensdeolrefc)tive analyser 5060 E(pEopspensdeolrefc)tive analyser 5060 : TTRrIiGgLlycerides! mmo1/1 E(pEopspensdeolrefc)tive analyser 5060 Creatinine pmol) E(pEopspensdeolrefc)tive analyser 5060 Glucose mol/l E(gEopspensdeolrefc)tive analyser 5060 urea mol/l E(pEopspensdeolrefc)tive analyser 5060 PPrRoOtTeEiInN,'T.total/ on E(gEopspensdeolrefc)tive analyser 5060 ALPrBoUtMeIinN, albunin/ on Epos selective analyser 5060 (Eppendorf) aPLrootBeuiLnI,N globulin on Calculation [PROTEIN T.-ALBWMIN] AAlIbGunRtAnTIOGlobulin ratio : Calculation [ALBWIN/GLOBULIN AAlpkaline phosphatase! pkat/1 Epos selective analyser 5060 (Eppendorf) _ Sodium mol) EFIX 5055 Flame Photoneter Eppendorf Potass fun mnol/1 EFIX 5055 Flane Photoneter Eppendorf Chiortde mo01/1 Jenway POLK Catetun mmol EFIX 5055 Flane Photoneter Eppendorf PIhNoOsRpGh.arPuHsO/SPH mol/1 E(pEopspensdeolretc)tive analyser 5060 + Page 16 - 000017 "= TELOMER ALCOHOL/TELOVER ACRYLATE! PFHS/PFOS NOTOX Project 242933 URINALYSIS (Recovery group annals only) UarsisniegnesdamptolesthweerReecocvoellreyctgerdouposverancciogrhdtin(gaptporotxhienatfeollylow1i6nghrss)chefdruolne:all aninals - pdruerdionsgethe treatnent period on days 7, 14 and at the end of treatment * at the end of the recovery perfod, prior to scheduled necropsy. UDurriinnegwatshecoslalmepcltiendg pienrtoioda asnpiencailnsenwevirael,depursiinvgedaomfetfaoobdolibustm wcaatgee.r wAafsterprovided canoalllyescitsi.on the samples were frozen and stored at -20C at NOTOX until further PATHOLOGY NECROPSY. anAaTesatnhientalissedsuruvsiinvgingethteorthveapoeunrd oafndthseubsoebqsueernvtaltyionexspaenrgiuoidnawteerde. dAe1e1plyaninals aasbsniogrnneadlittioestherecsotruddeyd.were necropsied and descriptions of all macroscopic fPrrioonrthteo aeoxrstaan.guiSneartuinonsaamplbelsoodwerseampslteore(d1-2atml-)20fCoratseNrOuTnOXcoulnlteicltifounrtwhaesrtaken faennaalylseiss.froInnadgvreorutpesnt1l,y,2, no3 sanedrun6 s(aamnpimlaelwansumbceorlslec9t7e-d100f,ron11a3l-l116M,ain12m9a-l1e3s2 aanndd u1s7e7d-18f0o)r. poIsnsstiebalde, fruretsheerrveansaalmypsliess. intended for clinical biochemistry might be SnaemcprloepssyofandtheFixfeodlloiwninngeuttriaslsuepshoasnpdhatoergabnusffwereerde c4o%llfeocrtmeadldefhryodmealsloluatniiomna:ls at IdAdernetnaflicgaltainodns marks ABroaritna CCoalcocnun DEpuioddiednyunnides FEeyneaslewitnhamoaprtyicglnaenrdvearaenad Harderfan gland _ HTeiaerutn KJiedjnuenyusm LLuinvge,r infused with formalin OLeysnopphhangoudses - mandibular, mesenteric oPvaanrcireesas - Page 17 - 000018 <= TELOVER ALCOHOLITELOMER ACRYLATE! ~ PFHSIPFOS NOTOX Project 242933 PPeiyteuri'tsarypatgclhaensd (jejunum, fleun) if detectable PRreocsttuante gland SSacliiavtaircyngelrvaends - mandibular SSepmiinnaallcvoerdsic-lceesrvical, midthoracic, lumbar : SSptleerennun with bone marrow STetsotmeasch TThhyymruostd including perathyrotd TUrraicnhaeray bladder : UATtTerugsross Testons ORGAN WEIGHTS sTuhrevifvoilnlgowianngimaolrsganonwetihgehtssche(daunldedtedramiynaolf nbeocdryopwseyi:ght) were recorded fram the ABdrraeinnal glands HKiedanretys LOivvaerries STpelseteens Bsottuhdyabrsepoolrutt.e and relative3 (% body weight) organ weight data are included in the LIVER SwpLING FTrefotn ala1teraanlinaTlisversurlvoibevinwgasufntriolzentheinscihseodpuelnteadnen/eNcyr.opsLyiveart slaemapstles1 wgerraem sotfortehde at -20C at NOTOX and on 01 February 1999 dispatched on dry ice to the sponsor Arneaployrstiesd b1ys tpheerfosrpomnesdor.undienrathseeparreastpeonsdiobcuimleintty.of the sponsor. Results may be _ HISTOTECHNOLOGY ARTe1covuenrdyerlgrionuepd oanrignaanlsandwerteisspruoecessasmepdl,esem(bseeeddeudndearndNeccurtopasty)a ftrhoimcknaellssMaoifn2-a4nd micrometers and stained with haematoxylin and eosin - Page 18 + 000019 ~-- TELOMER ALCOHOL/TELOVER ACRYLATE/ ~ PFHS/PFOS NOTOX Project 242933 HISTOPATHOLOGY Stlheidesscheodfulaelld sunadcerrilfiinceedfroorgnanasllaMndaintisgsruoeusp a(nsienealusndeorf aNlelcrodpossye)grcooulplsecatsedwealtl aTsesfironosm oafllalalninaanlisnalosf a(lall1dodsoeseggrroouuppss)whiwcehredeiexdanisnpeodntabnyeoausplayt,holaongdisatl.l gross Beaxsaemdineodn ftrroematmaellntrarteslatoefRdemcoorvpehroylgorgiocupcsh1angaensd,2t:he following organs were also - Trvoeurps;from males of the Vehicle control, Telomer Alcohol, PFHS and PFOS ~ pa5nVcerrea`Fsrofnrfoemmamlaelsesofof ttheheVeVheihcicllee CCaonnttrrooll anadnd PTFeOlSongerroupAsl;cohol groups. AT abnormalities were described and included in the report. STATISTICAL ANALYSIS The following statistical methods were used to analyse the data: Uinntievragrraotuep donief-fwearyencaensalysis of varfance was used to assess the significance of tIefstthe(mvaanryi-atbol-eosnecto-utledstb)e absassuendedontoa pfooollleodw vaarnioramnacle edissttirniabtuetiwoans,aptphelieDdunfnoerttthecamparison of the treated groups and the control groups for each sex. wThheen Stteheel-dtaetsat co(umladnyn-otto-obeneasrsaunkmedtestto) fwoalslowaapplineodrmailnsdtiesatdriobfuttihoen.Dunnett-test ! ATeNveltesotfsswigenriefitcwaon-csei.ded and fn all cases p < 0.05 was accepted as the lowest Gdriosucpretmeeandsatawer(escocraelsc)ulaitnedtheforsucmoanrtyinutoabulsesd.ata and medians were calculated for Tpeosotledstavtairsiatniccess.werIendcivaildcuuallatevdaluoens,thmeeabnassisandofsetxaancdtardvaldueevsiatfioronsmeamnasy hanadve been mreoaunnsdedforoffa bgeifveonrepparrianmteitnegr., Tyheetredfiosrpel,aytwdoiffgerroeunpts mtaeystdsitsaptliasytitchse vsaalmueesp.rinted References: _: A- MCuWl.tipDluenneCtotnparfson Procedure for Comparing Several Treatments with & Control, 3. Aner. Stat. Assoc. 50, 1096-1121 (1955) S-inRi.1G.tanMeiolulesrStatistical Inference, Springer Verlag, New York (1981). + Page 19 - 000020 "= TELOVER ALCOHOL/TELOMER ACRYLATE/ = PFHSIPFOS RESULTS NOTOX Project 242933 OBSERVATIONS MORTALITY No treatment related mortality occurred during the study period. Onnecerofpesmya.leThriescewiavsingcoTnEsLiOdMerEeRdACtRoYLbAeTEandaiecdcidfeonltlaolwindgeatbhl.ood sampling, prior to CLINICAL SIGNS RTaElLeOsVERwerAeLCOnHoOtLed in one male {mediately and 4 hours after dosing. This was observed at the end of the treatment period until the third week of recovery. ATELhOuVnEcRhedACpRoYsLtAuTrEe was observed fn two Main group females in weeks 2 and 3 of the dturreiantgmentthepeFriirosdt waenodk(isn)twoof rReeccoovveerryy. gPrioulposfreemcatlieosn vaatsthaelsoendobosfervterdeatfmnenttheanodne fienmnaeldeiatdeulryingandth4e fhiorusrts awfeteekrodfosriencgo.very. In general the findings were observed Agrohuupncfheemdalpeosftruorne wweaeskob8seurnvtield tfhmeedeinadteolfythaendt4reahtomuresntapfetreirodd.osing in one Matn APEHhSunched posture was observed fmediately and 4 hours after dosing in one male sateenthe4 henodursofatfrteeratndeonstinguntiinl onteheMasiencongdroudpayfeomfalreecoovneroyn.e oAccsaismfiolnaratfintdheingendwasof treatment. APEhOuSnched posture was observed in two Main group females in weeks 3 and 4 of attreatthmeenetn.d Aofstwheellitnrgeatomnentthepearbidoodm.inal skin was observed in one Main group male Odtihsecrolofuirnadtiinogns osfuchtheasskailno,pecwioau,ndss,alsvcaatbiso,n,scaalemsi,ssifnigssutraeisl wapietxh,blreededing on the = apanwds/,orswceolnltirnogl aofnintahles.earTheasned feyiendianbgnsormwearleiticeosnswiedreerednottoedbaemoonfgnothetoxtirceoaltoegdical rsaitgsnifoifcatnhcies aagse ianncdidsetnrcaeisnroermaicnoeudldwibethiantttrhiebutreadngetootfhebioblloogodicaslamvpalirnigation for procedure. - Page 20 000021 "= TELOMER ALCOHOLITELOWER ACRYLATE! ~ PFHS/PFOS NOTOX Project 242983 BODY WEIGHT `BToEdLyOVwEeRiAgLhCtOHgOaLin of males was decreased at the end of the recovery period when acnoimmpaalrsedrteomatinheedchoorwreevseprondwiintghincontthreolravngaelueosf. cAobnstorollutevalbuoedsy. weights of these BToEdLyOMwEeRigAhCtRsYLAoTfEfemales were s1ightly decreased when compared to control values at the end of the treatment period. pBoedsy weight gain of males was decreased at the end of the recovery period. Adbisfoflerutewitbhodystwaetiigshttiscalofsitghneisfeicmaanlcees. were also below control values, but did not PBroodsy weights and body weight gain of females were decreased with statistical sStiagtniisftiiccaanlcesfirgonnifwieceaknce2 woafstarcehaitemveendt uinntitlhethmeajoernidtyofofthecasreesc,ovemrayinlpyerifoodr. asbtsaotliustteicablodysiwgeniigfhitcsa.nceAnoinngwemeaklses,3 banoddy4weoifghtthegraiencowvaesryrpeedruicoedd.wAitbhsolute body wsetiagthitssticoaflthseisgenifmiaclaenscev.ere also below control values, but 1d not differ with Broadnygeweasighctosntraonldsboodvyerwetiheghttregaaitnmenotf aannidmarlescovreercyeivpienrgiod. remained in the same FOOD CONSUMPTION PAbEsHoSlute food consumption anong males was slightly reduced at the end of the 4wneotekorbescerovveedryanpyemroiroed.. However, after correction for body weight this effect ws ApbFsOaSlute food consumption of females was reduced from week 3 of treatment until twehieghetn.d of recovery. This effecpit was Tess apparent after allowance far body Aweneokngrmeacloevse,ryabpseroiloudt,e fbouotdrecloantsiuvmeptifooondwacsonssluimgphttiloyn wraesduwcietdhiant cthoentreonld voaflutehse.4- _- TwehiegrhetwebreetweneondainfifnearlesncerseceiinvifnogodTEcLoOnVsEuRmpAtLiCoOnHObLe,foTrEeLOoVrERafAtCeRrYLaAlTlEowaornce foranbdody contro animals. - Page 21 - 000022 - TELOMER ALCOHOL/TELOMER ACRYLATE/ = PFHS/PFOS CLINICAL LABORATORY INVESTIGATIONS NOTOX Project 242933 HAEMATOLOGY. TEAdLfetOcerMreEaRs4AedLweCeiOknHs,OfeLmraoldesb.lood coll count, haeaoglobin and haematocrit values were AAfrtteerr 42 wweeeekkss rreeccoovveerryy,, rperdothcrealnbidnisttirniebuwtaisondweicdrtehasweadsindefcermeaalseesd. in males. ; per fads. TELOMER ACRYLATE Adefctreeras4ewweeakss,notoatpaplarernetd balnoyomdorecelalftecrountthewa2-s asnldigh4t-lwyeekdecdrreuags-efdreeinrmeacloevse.ryThis Aofftenreu4trwoepehkis1,icdigfrfaenruelnotciyatles laenudcociyntcereacsoeundtrreelvaetailveed ldyemcprheocaysteeds rveallatuievse fvnalmauleess. : PParrottiharlombtihnromtbionpelawsatsindectrimeeasweadsininfcerneaalseesd in males of this dose group. AAfftteerr 24 wweeeekkss rreeccoovveerryy,, prerdothcrelolmbidnisttriimbeuwtaisonswtiild]thdweacsreadseecdreaisnedfemianlensa.ies. pAfrtiesr 4 weeks, total red blood cell count, hasmoglobin, haematocrit, total bnluomobdercoefllpcloautnetl,etshaaenndaptroocftrthroamnbdinprottihnerowmabrien dtiencerewaesreed diencmraelaesse.d Tiontaflenarleeds. AAdffecttreeerras42edww.eeeeikknss.ferrneeacclooevvsee.rryy,, prothranbin tine no statistically and total platelet numbers were significant differences when conpared to controls were observed. : pros Ahfateemrat4ow{certeksa,ndmeparnothcroormpbuisncultairnehwaeermeogdleocbirneasweads iinncfreenaasleads.in males and After the 2- and 4-week drug-free recovery periods no statistically significant differences were observed. - page 22 - 000023 = TELOMER ALCOMOL/TELOMER ACRYLATE/ - PFHS/PFOS NOTOX Project 242933 eerste CLINICAL BIOCHEMISTRY TELOMERALCOHOL After 4 weeks, total cholesterol, total protein and globulin values were dacreased in males. After 2 weeks recovery, total protein was still decreased in males. Values were decreased in males. After 4 weeks recovery, total cholesterol, total protein, potassium and calcium TAaEflLtbOeuMrmEiRnA/wgCelReoYkbLsuA.tTiEnotraaltiocsholweesrteerionlc,reatsoetadlinprroatleeisn.and globulin were decreased and AAfftteerr 42 wwaeeokkss rroeccoovveerryy.thteostaeldpirfofteerienn,cespotwearsesiunmotanadppacraelnctiunanyvaaalruee.s were decressed in mates. Apfottearssi4uwmeevkasl,uesaswpearretatdeecraenatsneodtraanndsfearlabsuenianc/tgilvaibtuyl,in trotaatliosprwoteerien,incgrleoabsueldin inand Dates. After 2 weeks recovery, glucose values were increased and sodium values were AGdfaetlceerrieuans4ewdvaeliaunkesmarlweecesor.veerUdyre,ecaretwaoastsaeldipnirncortmeeaailsnee,sd. iinnofregmaanliecs.phosphate, potassium and pris tArfitgelryc4erwiedeekss,, atsoptaalrtaptreoteaimninoatnrdangslfoebrualsien vacatliuveistyw,eretotdaelcrecahsoeldestaenrdol, aSlnbcurmeians/egqloibnulmailnes.ratiToost,al alckhaollienseterpohloswpahsatadseecreaacsteidvitayndancdhlocrhildoeridvealuweesrewere aAinfnytcmeroreraes2.edweaiknsfermeacloevse.ry, no statistically significant differences were observed VAfetresrbe4lwoewekcsontrreoclovevrayl,uestowtialthchsotlaetsitsetriocla,l sgilgunciofsiecaanncde.potassium values in males KpFrtoesr 4 weks, triglycerides, atostpea]rtaptreoteaimninoantdrangslfoebrualsien avcatliuveistyw,eretotdaelcrecahsoeldestaenrdal, aVTabluumeisn/wgerleobuiinicnreraasteidosinafndemaclhelso.ride ers increased in males. Urea and chloride AAtffottteearrl p42rwwoteoeeeikknss, rrpeecocootvvaeesrrsyyi.umnoasapsnuadgrhtcaaFtliecniduaimmnigvnsaoltuwreeasnrsefweeorrbeasseredveecadrc.teiavsietdy,andtcothallorbiidleiruwbaisn, increased in fates. page 23 - } 000024 "= TELOMER ALCOHOL/TELOVER ACRYLATE! -- PFHSIPFOS NOTOX Project 242933 PATHOLOGY MACROSCOPIC EXAMINATION MCaocnrsoisdceorpeidctoobshearvveatairoinssenatasnaecrroepssuyltdiodf ntorteatrmeevneta.l any alterations that were T4h1ed fneowt mdaicsrtoisncgoupiisch ftirnedaitendgsrartescofrdreodm tathealvlehiscalcerifciocnetsrolwergerouupn.remarkable and ORGAN WEIGHTS Apfrtser 4 weeks, Tver weights and 1iver:body weight ratios wers increased in Amaflteesr. 2 and 4 weeks recovery, this effect had disappeared. wIeneckrearseecdovebrryafnp:ebroidoyd wiesigahtttriabnudtetdestteos:tbhoedys1wiegihgthlty rlaotwioasutoopbssyervbeoddyawfteeirghttsheo4fthese animals pAfrtoesr 4 weeks, autopsy body weights were decreased in females. Liver weights and rTaivteirosbowdeyreweiingchrteasreadtioisn wfeemraeleisn.creased in males end females. Kidney:body weight A`fitncerrea2sewdeeiknsmarleecsovery, 1iver weights and liver:body weight ratios were still AFfetmearles4 waenedkskidrneceoyv:ebroyd,y w1eiivgehrt:broadtyiwoesigwhetreraitnicorseawseerde ininfcermeaalseesd. in males and wOetihegrhtschaanndgesinncorteeadsedinbPrFaiOnS:btordeyatewdeiagnhitnarlastiofsncliundefdemadleecsreaasfetedrab4swoeleuktse ohfeart tirnecartemaesnetd ainndma2wleeseksa.ftreerco2vewreyo.ksInrecadodvietriyona,ndatbesosltuetse:bosdpyleewneiwgehitghrtastiowserewere siTnicgrhetalseydTaofwteorr 4hiwgehekbsodyrewceoivegrhyt.s AaTt1autthoepssey.changes were Tikely to reflect AOLrCgOaHnOLw,eigThEtLsOMEaRndACaRrYgLaAnT:Ebodory wetghtwerreaticoosnsiofderaenidnatlosbetresaitnfeldarwittho tThEoLsOeMERof control aninals. - Page 24 + 000025 ---- TELOMER ALCOHOL/TELOMER ACRYLATE! - PFHSIPFOS NOTOX Project 242933 MICROSCOPIC EXAMINATION (see Appendix 1) ATfEtLeOrVER4 wAeLeCkOsH,OLmidzonal/centrilobular hypertrophy vas seen at a mininal or oSfTimgihntindaelgreoer sinlisgihxt mdaelgerse.esIonftheexocprainncereaaspoaptossliisg/hstinignlcereaceslel innetchreosiisncwiadsence Arfetceorrde2danidn 4sixweemaklsesr.ecovery, the Tiver changes had partially or completely grersooulpved and the pancreas findings returned to the level of the vehicle control A[ftaer 4 weeks, midzonal/centr {lobular hypertrophy wes seen at slight to moderate Adfetgereres2 wienekaslirmeacloevse.ry, this finding had partially resolved. After 4 weeks recovery, this finding had completely resolved. Apfrtoesr 4 weeks, midzonal/centr lobular hypertrophy was seen at mininal to Amofdteerrat2eanddegr4eewseekisn ralelcovmearlye,s tahnids.ffemianldeisn.g had partially or completely resolved in females, however remained in evidence in males. wTheererweimtahiinndertheofrtahnegemiocfrobsaccokpgircounfdindpiantghsolorgeycorednecdounatfteerredtrfenatSmpernatgueandDawrleecyoverrayts cofonttrhoils aangde tadreastterdainratasn.d occurred at similar incidences and severity in both DISCUSSION AND CONCLUSION PFoFlHlSowoirngPFOdSaitloy moraalle aanddnifneimsatlreatiSopnrsaguoef DTEaLwOlMeEyRrAaLtCsOHfOoLr,atTELlOeWaEsRt 2A6CRYdLaAyTsE,, PtrFeOaStngernoutp-sr.elated changes were most pronounced fn the TELOVER ALCOHOL, PFHS and sHeeepnatoicnelalnuilnaalrshryepceeritvrionpghyPFiHnStahendTPiFvOeSr.toIgnetthheerTEwLiOtMhERhiAgLhCerOHOlLivgerrowuepigthhtes was Thheipsatilcivehrypeenrltarrogpehmyenwtasisnontosatccolmipkaenlyiedrelbayteidncrtoeastehde hliigvhererweeingzhytmsa.tic activity wiansmertaatbhoelrtspienrgsisatexnetnobsiiontciec itcowmapsounsdt.illAnoonbgsermvaeledsatrecteheivienngd PoFfOStheth4is-weeefkfecdtrugfree period _ MpiannicrraelastoofsmTailgehst erxeocceirviinnegaTpEoLpOtVoEsRis/ALsCiOnHgOlLe fcoerll4nweecerkossisanwdashadrecroersdoeldvedinafttheer the recovery period. - Page 25 - 000026 ---- TELOWER ALCOHOL/TELOMER ACRYLATE/.~ PFHS/PFOS NOTOX Project 242933 Iinnveosnteigoartiboontsh osfexetsheabfltoeordtrsehaotwmeedntt.hatThevamroisotuschpaarraacmteetreirsstiwceredecsrleiagshetslywerreed!uced ~ ttoottaa)l cprhootleeisnteraonld gilnobaulllindosfen galrloupdsoseexcgerpotupsf;or the group; tasrpiagrltyacteeridaemsinoitnratnhsefePrFaHsSeanadctiPvFiOtSygraonudpsp;rothrombin tine in the PFHS and PFOS groups. dIrnugt-hefrmeaejopreriitoyd.ofAcpaosesssibtlheeseexpclhaanngaetsionwefroernotthesoebsecrhvaengdesanycmoourled baeftelrivaer2-dwaemeakge Hasowetvheer,litvheer oisnlyinmvioclrvoedscoipnicthechasnygnethensoitsedanidn tmheetab1oivleirsmweosf thheepsaetoccoemlplouulnadrs. hsyhpoeulrdtrobpehynotiendtthehatTELtOhVeERmaAjLoCrOiHtOyL,ofPFvHaSluaensdrePmFaOiSnegdrowuiptshionnlyt.heMarraenogveero,f viatlues tChhaatngecsan1nbecelxipnieccatledbifoorcheanniisntarlys opfaratmhiesterasgenoatndedstarfatienr. 4 weeks of recovery but i niont thaeftesrtud2yweietksseweemsrevecroynsiudnelriekdelyto thhaatve tohcecyurrreepdresbeyntchaanncee,ffeActtthoifs trteiantemepnoti.nt gFrlouucptsu.atMioornesovienr,eleucrteraollyetveelsleavnedlskwiedrneeysweeenighattsawlleretimiencproeianstesd aifntearlltrdeoasetment diynsffeunmcatlieosnraetcemiivcinrgoscPoFpOSi.c HToewveevlert,hesien tchhaengaebssenacree ocfonseivdideernecdetoofberenoafl little toxicological relevance. Hhaaeemmaotgolloobgiincaalnd/eoxranihnaaetmiaontorciertveavlaelduessliignhtalnyinadlescretarseeadtedredwitbhlooTdELOceVlElR AcLoCuOnHtsO,L, nTEaLtOuMrEeRaAnCdRYnLoATfEu,rthPeFrHSeavniddenPFcOeS.ofHoawnevaenra,emiscincreespthoenseefwfaesctsobwtearienedsliatght in miascrdoousbctoepdi.c oOrthemricrhoasecmoaptiolcogliecvaell, chtahnegetsoxinoctoeldogiwcearle nroetlevsaunpcpeortoefdthbeyse Findings ctoorbreespoofndliintgtlesigrneslevoafncteoxailcsiotybaencdausaegaitnhethvealuteosxiwceolroegiwciatlhinimptahcet rainsgeconofsidered historical data. Arneceeifvfiencgt PonFOSb.odyThiwseigehftfecatndlfaosotdedcounntsiulmpttihoenewndasomfosttheprroencoouvnecreydpaermioondg.feBmoadlyes owefigthrtesatmoefntf.emaOltehser reecfefievcitnsg onTELbOoVdEyRwAeCigRhYtLATgEainwearned sfloiogdhtlcyonsruemdputcieodn awtertehemaeindnly s1esenattatachtehde teondthoefsethefinrdeicnogvsery period and therefore no toxicological relevance CGlbisneircvaeld siingcnisdensutcahllyasina ahlulncFheidvepodsotsuereg,rouppisloeirnecatifoenw aannidm/aolrsroanlleys. wAetrethis low rienpcriedseenncte aandcletahresienvdeirciattyionobsofervteoxdictihteys.e symptoms are considered not to _ Fcroontnrotlhecornepsuolutnsd pPrFeOsSendtoesdedfnatt3hismg/rekpgo/rdtayfwtascanindbeeedconthceludceodmpotuhnadt twihtehptohseitimvoset sbuttrikliensgs sanedverpeerseifsfteecntts aesffPeFctOsS, imnacilundleydinPFHtShe(1l0ivemrg./kgC/odmapyo)undasndwTiEthLOMcEoRmpAaLrCaOblHeOL D(e3s0pimtge/kgs/ldiagyh)t.ly reduced body weights in females (TELOVER ACRYLATE only) and sone pse1r1ghdtaycdhiadngensotinrestuhletblionodcleaafrtersystrteeamtimcentto,xic3i0tymg/akngd TorEgLaOnMERdyAsCfRuYnLcAtiToEnorat macroscopic or microscopic level. - Page 26 - 000027 ---- TELOWER ALCOHOL/TELOVER ACRYLATEL- PFHSIPFOS NOTOX Project 242933 FIGURES 27 000028 -- NOTOX Project 242933 BODY WEIGHTS MALES GRAM omer py A 200 -. BW-0S8R-LDYEC--981 -- oo re a FZ A EES A sZtef Set 7 Z4or 0 . 03 I 7 I ` WEEKS re GGOPW 21 ((TVEELHOQMLEERCAOLNCTORROOLL)) CIIIIIT goes move nate) ee GROUP 4 -------- GROUP 5 (PFHS) seme GROUP (PFOS) 28 000029 -- X NOTOX PrPorojjeecctt 242'933 BODY WEIGHTS FEMALES GRAM ------ w -7 coer BW-SPLT - 2 08-DEC-98 300 Ee =A EN TTT 0 _ 00 2 + 8 WEEKS C------I----T----eT--e-- GGGRROoOUUwPP 2s1 (a(VTmEEHLoIOCrMLEeER CAAOLNgCTOaRROtOLLe))) 29 ems----- GROUP & --==----=--- GROUP 5 (PFHS) --ssmmsss GROUP (PFOS) 000030 ~-- NOTOX Project 242933 } - BODY WEIGHT GAIN MALES BVG-0S8h-LDYEC--98 x meaner covery 0 = . oT Sf 0 [ F 7 Aa NoA Alfif = # i 60 \ F 40 x -- 0 0 2 4 8 ves SoooGP 3 (TELOMR AGRYLATE) =------------------ GROUP 1 (VEHICLE CONTROL) wesessseeseseoe GROUP 2 (TELOMER ALCOHOL) E ZIT T -----s--s--e----- GwcRooOUpePs4 iernss) 30 000031 ~-- NOTOX Project 242933 -7 BODY WEIGHT GAIN FEMALES x en recovery i 100 BWG-0S8P-LDTEC--582 . : % "0 PETAFe Tm FA i 7 Nj 7 i! 20 7en" \\7 - o 0 2 + 8 WEEKS "= eeeeeseseeee GGRROOUUPP 21 ((VTEEHLIOCMLEER CAOLNCTORHOOLL)) m ===m == =m==GGROOURP 43 (TELOMER ACRYLATE) --------- GROUP 5 (FHS) eee GROUP (PFOS) 31 000032 -- NOTOX Projiect 242933 -- FOOD CONSUMPTION MALES FCO-LSAPLRT --91 G/ANIMAL/DAY |TREATMENT [RECOVERY . EresE i A2 == == Noo 20 0 . 5 - 0 2 ` 8 WEEKS = cecareceeeees SSSSCSC GGRROOUUPP 21 GOP3 (((TVTEEEHLLIOOCMMLEEERR CAAOLGNCRTOYRHLOOALLT))E) -------------- GROP 4 ---- = ------- GROPP 5 (PFHS) ----ses--ee-- GROUP (PFOS) 32 000033 "-- NOTOX Project 262933 -) FOOD CONSUMPTION FEMALES (G/ANIMAL/DAY |TREATMENT [FeoveRy : 30 FC-SPLT - 2 01-MAR-99 = == | Et 5 . 10 5: -o 0 2 + 8 vans OP 1 (VEHQE CONTROL) wsesssssseaeees GROUP 2 (TELOMER ALCOHOL) ==== =--==---- GROUP 3 (TELOMERACRYLATE) ----------------- GROUP 4 ET cops ens sven GROUP 4. (PFOS) 33 000034 -- NOTOX Projectokt 262933 - RELATIVE FOOD CONSUMPTION MALES RFC-01S-PMLATR--991 G/KG BOTDeYATVeENIGTHT/DAY 120 DN 100: 0 @ feconRr ~ TENSeka, anSIN NEE Sead "0 20 - 0 2 4 6 == seeesaseseeses GROUP GROUP 21 ((TVEEHLIOCMLEER CAOLNCTORHOOLL)) -- om -------~ GRO3 (TELOMER ARYLATE) --m= GROP 4 e -----e -----e ---- GROUP 5 (PFHS) GROUP (PFOS) 34 8 weeks 000035 -- NOTOX Project 242933 -- RELATIVE FOOD CONSUMPTION FEMALES RFC-SPLT - 2 01-MAR-99 6/KG EAT BODY WEIGHT/DAY recovery 120 ZS! , E BiEmEa sema. h 100, eT ~~ = NN S -- v2 60 40 20 . _ o 0 2 + 8 WEEKS ------------ OP 1 (VEE CONTROL) m"eeeosasemnsesoees RGROOUPP 32 ((TTEELLOOMMEERR AALCCROYHLOALT)E) m ----l -- wPrSk GR) ree GROUP 6 (PFOS) 3s 000036 TELOMER ALCOHOL/TELOMER ACRYLATE: ~ PrvsImROS NOTOX 242933 TABLES - SUMMARY DATA 000037 36 _ NoTOX Project 242923 -= svuT-osonu e-s1 MCALLIENSICAL SIGNS (SUMMARY) GROUP 1 (VEHICLE CONTROL) star oo.craoe) oman TBOeE ALaAsAseALiAAaRsNAsRNesAdARaANiABsABi AABe NAAsAS sc / rm / oc Nora 3) Gt errrrenirierinsisosJenUssLecnesoeseereeense hnaorma (3) ahoaea (3) GS t ero ie m SHI, eee GCF wIeenie MINIM. NrooRresni0a)n) Nhoorens:Le3)r pmras sem sca ans (3) vasacus G-UNI IT , eee 8LR r ere MEr UMreN ee NO m err HE n NN, ING, o.oo GI t orrerrrin so MI T MT I eee :T:oMaPaaedrticaeennrtvaColrfauaaettofmefacncttheed(htCinMgi)hzeasltAsci(0n3.d0i0vildeusaslTBt:hga4rn.a0d0e5bs. 1 =between 5%and 15V,.... A =sorethan 950) - 37 000038 o-- NOTOX Projieect 242933 -- MCALLIENISCAL SIGNS, DAILY (SUMMARY) GROUP 1 (VEHICLE CONTROL) B sx poxe .cance) wm: TseocoBen dS. sc /rm / mune Naoamen S Gt en A E IE B5uanRGEamE (1) ooiaew3)m GFt BBerrien By B Prinsuipeen sssei rsiseo rndion smss sou2-5so5n 0- 5a . :MFediaenvoarflauefcfoefctutheednhaingihmceaslts i(n0di=vliedsuasltdhaainly5bg,ra1d=ebs et5%waned19e%,.n.., A =morethan 95%) 38 000039 -- norox project 242933 -- snTsoin s- 5 ACLLIENSICAL STGNS (STaaaRY) GROUP 2 (TELOMER ALCOHOL) saons coer mom BBoE mneiasn si AAtAaSiA is sStaA sisAid son rn race Nome 0) m=orsme 0) RS re Ses S co o IIn, Somme T$Gh1oNnBodafatnevrTaClrueLenotmfetnthe(LhLiREgTheSsAe:tB r0s.t0v0I iaum8)E4:R08 beeen 8 am 350, 2 re han 50 39 000040 -- - CinLiIeNsICAL SIGNS, DAILY (SUMMARY) fr samy `GROUP 2 (TELOMER ALCOHOL) ann Fm se 1 rom + nace oS t EEm E pri . i G$oYFetoirmaoutSneftacttheed igahteset(r0 ivteisas tshaatnTEcriheserve 58and19%,..., A =morethan 959) 49 000041 NOTOX Project 242933 ~- sneT-asoln s-]5 MCALLIENSICAL SIGNS (SUMMARY) GROUP 3 (TELOMER ACRYLATE) Star voce) mane TDOaEs!: ALAAASSE ATAAEAe AA EASAT SARA scr/ om / snags nCorEm 3) Naowrm (3) NrooRrELeR)0 s(i3)te) OSai MUIoan o8F iH n EMEL. ooo. mHiEEL eevee scans (3) GE niin, 3:h;oMaPoedractaetnnrtvaoClfruoeanttfmoaefncttheed(KshHniLlg)zhaelsstA:i(0n0.d0i=0vildeusaslBtihga4r.na0d0e31s, 1 =betvSehwannd I... A =sothranSe50 41 -- HoToX Project 242933 .- MCALLIENSICAL SIGNS, DAILY (SUMMARY) GROUP 3 (TELOMER ACRYLATE) Ssxeoota.cave) wm, RTeocoved ry S sx/ om / sunoce Ra Dsnms (1 $Git r reir e A: sruTs-sTuaxnT-sS ML odianvalueofB thehighestiTnivHidudaalilyTorT semen 50 mt 150... = more chan 950) 42 000043 NoTox project 242933 -- MCALLIENSICAL SIGNS (SUMMARY) GROUP 4 snTeasls- ]gq star nox.coe) scan / Fon J munoce TBOEs: AmAaAssAReAsN lARa AAB stASe ASERd SAGAD s[ca=ns (3) Bmsome (0) S Gt errrreri eno ter nn 8 rrr seenerens etree TG:oNaPacatfiteaenrvoaCrlrfeuaaefctofaefacntuttheed(nhaHinHgi)hnseasltAs:i(n00d.i0=v0ildeusaslBitghra0and0e3%s, 1 =betSbwandeISe%,.n.., A =more than 95%) : 43 -- [Ep -- -- MGCARLLOIEUNSEICA4L SIGNS, DAILY (STAY) EaxEa go.cons ms, sons acon rn)mm = RG 6S cE oAoR n wnsaoos rie, wn 0g< S BaEmEuN s rRoDr G$ oes n [T--R-- SGEBE orn oRnEe 1oe Ga EE rErR ; o$r YeFttan TtunLof onHgEhar oR ii city E miMesace 5T hsat250, A = orecha95n0 44 NoTox Project 242931 .- MCALLIENSICAL SIGNS (SUMMARY) GROUP 5 (PFES) sa1n7s5ux00-539 zattox.cece) sosToRs TDIsE: AL AAU AAIAS AAARAaAsAeAA aAsAe S xan rim / mises nDTsmEa (3) Gt smo mmrrento anos . T3iinPMeeeardfcietanentrvotarfleuaaettofmefecnttthead(ah1in0gf5hr)easltsAt i(0n0.d0i=0vilduaelBfrags4rn.a0ds5e01s, 1 =boc5w4 aecden 15%,., A =sorethan 350) 45 000046 -- - CMALLIENSICAL SIGNS, DAILY (SUMMARY) `GROUP 5 (PFHS) s101 go.coms smoomy HRGED FOSTURE (1) scan 1 ron 1rma F-- EBIR Gy Prrrssssasossssrtrarborras G i eooer E EE EE G1 ationvaeioef nhe hia ghestLI ivE dtityTcrnsdaenmen 58ct 350, 46 A = orecha35n0) 000047 _ Not0x Profece 262933 -- GMcLRAnOLNUEIESCA6L (SsIoGsN)S (STMMARY) nas san oo cen BE eal on rn rues snuncsonsi AwoeBeTA (3) 8 cerrerssessesScHeArMcIrLrvmses rensseneersne PG$11RFStRonETtounLroLfEcoSmBghEar ta(P sivMicEuAns gR,aiTns 2 een 5 st 50, mre m50) 000048 --- NoTox Project 242033 -- CMALLIENSICAL SIGNS, DAILY (SUMMARY) GROUP 6 (PPOS) xcan e now.cl oe) EE: sToeocdo e dead sc / Fm TnogE Tia>mseame 00) GS t eriR n EE L snpsroiw v-y1a > GtMevdaL luie oh fathenhBigheEst nPalE vidudaally graTdehs een 54an 130... A =sorethan 359) 48 000049 ----- Noor projec 202933 "- snucasoax -- 313 FCELMIANLIECSAL SIGNS (SUMMARY) GROUP 1 (VEHICLE CONTROL) stanoo.cao) men BmEa A pavessrA liesebA itiS ond san rn mone ALOPECTA (3) po Bt ensinennsseeeenss irene sre srr ------------------__o ) 8 revvinnsiensnnii rere SM ees anoa rm 3) nronrman0)) orrencnyRa0d)i oi rem ten Noavemod0)erm) NoEarmRo0)naam pr sous &$n BEET Som E rere ER IE II Soorneon HHLNIIGL RR GIT SG om I REEL 8S HIE I RRLE a... SERBHI St errr SH. co. rrr JHE -- nssons sEaLmsray) Seoerime I EI RL N. E HoRaTnHe Sram RT rAeeB 5.00--BI -- E C08 1E botvoR rn50amt. 130.0... sorethan 35%) 49 000050 NOTOX Project 202933 .- CFLEIMNAILCEASL SIGNS, DAILY (SUMMARY) GROUP 1 (VEHICLE CONTROL) sotanono case) WES: eDmoonvnER2y s Dee binnndSe sn / ro / susace p= re orem, 3) Gt nernvieriAateinnign ET -- oa pera (3) N=om 0) Nroarsmaan (3) or ree m 3) ormieensze3)) Norriedeanm, e3)1am) orvcen,a(3)ram saamasa3)) G S eL omR @O errs Ha l, eo HEHEEHDL......... 8 m dam nam . oSi d mmmaa .... ..1..1..... m mm n mII o$ m Ea L OO o dUE HML eE ee snTushone1aa . -_ 8:: YPoedricaenntvoalfuaefoefcttehdehaingihmeasltsi(n0di+vildeusasltdhaalnly3g%,ra1d=ebs etSwhaendeSVn, .., A =morethan 95%) 50 000051 Nozox Project 242933 _~ sva-1s9on--5815 CFELMIANLIECSAL SIGNS (SUMMARY) GROUP 2 (TELOMER ALCOHOL) sta vax.Grace) Texan STOaE ADvAaAesAeAaNsAaAsAeAiAaAiAoAeArAtAiAaSsend sou / rm1 once Ee] nt ee oarca 3) pe S MHE IcovI dI es e InL Gt curenniisnniiiee nines. JAR. Ho:aMFoatfEttaeRnrvTCarlLeuneiEmoaEfntthe(ShHiLgEDhesAtsiBn0d.iU0v0iIduaRlBigIr4aI0d8eEs Leen 5had 250,00 51 6 erethan350) 000052 -- NoTOX Project 242933 -- CLINICAL SIGNS, DAILY. (SUMMARY) FGERMOAULPES2 (TELOMER ALCOHOL) ZSo10o0moxcate) WES: sLeocoouenRZyane denedSe sco ron 4 manoce Mmoo ) r3) OS i erve BE TEE eerie looar=etme3m) or aM E IE loora ea3m) GS t eoEHE EERL eerie sGoumzst0a)n $ Gt cere HHI L cree : sGasms 3a) m GR t erere E HL ereE erenrees swt2-5-swuAnR-4365 ' . . GStt MPeedricaen:va3l2ueeofifctthead hmingfhreasltl i(nt=iv1i0du2a3lcdhaainly30g7ra1d=ebs ecu5%aenden 52 15%,. A =morethan95%) 000053 wosox protect 20233 -- svehsaan n<]1 cTGLRoDOovUuIPECsA3L (STIEGLNOSMER(SAUCMRMYALRYA)TE) masa axaposecee 28 S nh E iI eu N tiE se dh arose 1) scan ons soca G1 ememrime IML i psurorm)en 1 a= rmen 1 o$ mEEmEm 1$remreeeserJsEIeEeEseoesrreeroerserses = eneran 0) i E22mSemanm 0) 2TeSaiat0)) mmm -- i$r m ee ESEUEI s orese JH... D $m S E--R -------- H$aMtradHEizFe TatRuLn oLEfchTnBigEraECtrR0ivAiaEl grIates| seen 58 wt 150, 53 8 = oretha9n50 000054 _ HOTOX Protect 242933 -- FCELMIANLIECSAL SIGNS, DAILY (SUMMARY) GROUP 3 (TELOMER ACRYLATE) Lsioaionx.cae) Ws: eDomoocveeRby enedeni sosrune RAEDFosTURS (1) Su / von 1 nace Frey o$ B MUNE I 0 Ail ovnssinssnssoinsoonts pratea 5stan (3) o$ a HUn I.. .. Bh corsvisossonteomsersndy so2-5s5om -51s9 9FMeedmianmvaeSlEueSoefattehdehBighEesEt.indiI vidual EdallTy Tgradess erv58eanrt 150... A sore chan 950) 54 000055 NoTOX Project 202933 sru-Fsuni-e19 FCELMIANLIECSAL SIGNS (SUMMARY) Grou 4 sar oo.cece) meaner TSHeE ApAAaAAsAseErAABsANAlAi NAsAsNNeA S HNHED POSTURE (1) sc / ron / vusace sTaRnRea oTvEers 3) oarsem 3) awroirEaEnmsna0)do sons o) GS i weo rnn er n sd IIIT S @ cocrerenI ers SEIR MIL vE eo ssumsessreseresesnensesms Son ceerieerieeni es A JTU E RL E III La. 1, GS ere I II II NE Gw reo T n EI RNE L G6 erin AEHINL ea BEEastteannme (3) [RECsomaEnms (3) seone/mTemIeoTInn G Se orm rm MeEHe tL se ees G$ eren AIY IM H3i:nPeHeoradcfietaenrv3aS2lruoeadteomffeantcttheed(ahUniRgfLhoeasltsA:(i00n.d0=i0lvoisdeuBtihga4rn.a0d0e3%s, 1 =bet54awnd1e5V,.n.., A =morethan 950) 55 000056 -: NoTox Protect 242933 CFELMIANLIECSAL SIGNS, DAILY (SUMMARY) GROUP 4 soareoo.cance) WEEK: sToeocoveRyRudebrn 5. sn/ vor 4 vunace Fe) 8 sssersssrosmtsniessuiends R[m sEmaenme 3) Gt eadd ennan #2r0seanmeTea@)moanmraaT 8 L cer1 s l 1n 0 soca/smrxciRsaTInoy "IEOTEERrEeDamIAPNRAEBYE (0) 06 g vvvserssenss en tnies sve-2s8o0x3--3280 9S: NFcetricaennvaoltuSeeeofcthaadhaingihneeslta i(3nt=ivliedsusslthSaanllSy00graIde=sbetween Sbsnd I5%,.... A=morethan95 56 000057 Horo protect 242933 sou-psoni-)23 CFLEIMNAILCEASL SIGNS (SUMMARY) GROUP 5 (PFES) rca sta oa Gos) rewBeE bE een ineiess eereaeses ntased sosrane HUNCHED POSTURE (1) tzemngaiies senate de - pSKIr N /FeUR / PLONGGE Gt corer ABIL : o=mens 3) o C u Hm Em ER m S. , hsom re 3) n Gi en SI i L s= ams 0 w=n 5) soo/nmeeme r o p Hm EE NE RI . eheeE MLL G$HoaFltotRToE0nE vTalEoRS neofkthE aehBigET heEstLnBBs3iE0viNd mEgra1des1 becvenn 3and 57 258.. A morecn950 000058 wotox protect 242933 CFELMIANLIECSAL SIGNS, GROUP 5 (PFES) EstBan po.crace) sn/ ron nace fa ren naor naoccra m 0) seoar?e i(1am DATLY (SUMMARY) Vs: rToeocovhee denne gSi isomvpvmssseesmissssdlsl o$ 1B pm E S m E m u em n B cora resm sree sun2so0nan--3232 - G$:1MHEavTadluLeoaflchn eBhighEestiI ndivdiaidlyTugrTaadless evesno wt 150, 6 = rethan 350) 58 000059 NoToX Project 242933 FCELMINAILCEASL SIGNS GROUP 6 (PFOS) sa vaxce) rosTune. (STMYARY) meme TDRrE AviAesAes Ai AAARs NAABs N n senTsoh-a23 baAsReSAdS Sn / rm J wnace FCrEeEre aroerreecznd(o3)m orroecnnsa s(3e) m OS F errr A n IG , a. GSeren om I, I. OSroemn 2EE0, TI. Re stan (1) ly 13min eyribsssttsssimites totates russ Bisons me Sic e eree s eee HG3:o;YnPooadrfoatmennrcv'CaorlfounSectorfafanctttheed(hmiLigrThaelsstAo(d03.i0=v0ildeusasl8tgthraan1d0e53s0. 1 =batueen 5%and 15%... A =morethan 359) 59 000060 NoTOx Protect 242933 CFELMIANLIECSAL SIGNS, GROUP 6 (PFOS) oxat n vox.cance) sca /Fm 4 sunoce praec=ornyy Rieasd)ane (3) sae stteom (3) REasTmaandme (3) 2as)an (3) DAILY (SUMMARY) WES:T`omaocovBeRy e Beene S GF MILn m nI n o$ H aIsIsLiIzLa OS f co HE L eI ens BGp onceontornlifucsosnsonmesrint 1$ sovncereiiifB uvinsibrsrunt sve-2s3o-n1aR--3254 OMariaenvnalueeoiftdhehnigehleslti( otlv1idulBdaallyTTgrTadeTs he5c3anet19e%,n A =morethan358) 60 000061 NTOETLOOXMERProAjLeCcOtHO2L4/2T9E8L3OMER ACRYLATE/ PFHSIFoPFOS BH09S-WD5C.-981 BMAOLDEYSWEIGHTS (GRAM) SUMMARY ReATENT VGCohapmsi GAToocwpoeLrr GrAeeMgveAInTe GOP4 rGiOsP GEoSes oVvx 11 eSW ome. 2Ci08T PY hi i22W9 25i.04 ii2sw8s a1i00 - owrx s1 emsN oe =iis i2it7a j2at 2iio8s =i1es 2ii,s WoyE s 2 esW to. 2iis8s 2iis Fiiwys 21i2 2ns i P7ys i woye 122 esW two. m2i07 aiimne 75is aiir 2Pi0as 72i wovs1s esW tmo. 2Pi5y2 228s p2ib8o3s 2ii8 aafdss P2iy oWvx 13 ESW ome. s2iz8's ao2ie S1i004s a2i62 a3in04 s20i% owrx m esmtow. P2i7o4 a2i'6s ahisd 2ai6s.5 2ai0s7 aSii oWye m4 esWmto. aFiy F2ia4 ais F20S4 Soiims s3iss ; owrx m eNmsoe. 5Fi3r6) 0ais aii3o wSwirs =3uh 03u% "1+: oumnett-Test based on pasted vartance sfgnificant at 5% (*) or 1% (**) Tovel 61 000062 NTOETLOOXMEPRroAjLeCcOtHOL2I4T29E3L3OMER ACRYLATE/ PFHS/LoPFOS BS09W-D.EC-982 BMOADLYEWS EI(GGRAMH)SUTMMASRY Recovery Gaopei msaope TGOHPOR GORA FGsPS Groes e - Tome. MCWL AGATE WoyE 11 eNstmoe ParYs 28a aiu `022 a0u waiis - Wove 51 ENsrmee. s8ta po`set] azts `smnts sEza =@ owrx 82 EWSome. Swass 37 1 2a 6 P3Ya 8ls i wWxou2 SVEtmee. a2:8 3a:50s a`mno p`wr) was iom WoyE 2ou estmer v 3=24 aFYs 2oms a80 u7ss a7` s Wore 31 seWrMee. wF3tC Es2a] 3792 3a3% 301 s5t7 w[ReE 4 sW)to F2e02 sm5 s 3223 ass 3=a 3se oWarx a sseVstmoen. 3w3 1 Sts 3w78 3@7 8ns 3,stms wora mesWmoe. a7s soma 23a6 os6 3o=s sa5n e 1 ++: ounnett-Test based on pooled variance sfge nfficant at 5% () or 1% (*1) level 62 000063 NOTOX Project 242933 TELOMER ALCOHOL/TELOMER ACRYLATE/. So PFHS/PFOS' BSW 3 09-DEC-98 FBEOMDAYLWESEI(GGRAM)HSUTMMASRY meaner S TGordiEhmM pe:EGfN oore: wars wsearops ames wwrero1 we i w Biy wi wiBe eliom aiow 3 W or e5 reem wim o m oiw miom oi@m oHBym 00kosm w or o8 revmm iEwoe oiW w miow iwB m m%wmHs wweorm # iew 0iwweHis B m i m di iBwmy 55m%e wwoer Sieme B iws B.iom iiwm B iom BWiwe we i wwoer eome #m we Biome iB me Bm2e oiW m Biwee Wweorm 3eWme B wim BYoime w i omBL oB im imee WoyOEmemvWn R m i oB wi iBowN oiBme oiB m Wiwre W or mReB mv B m i oB mi BwiTc Bo%ms oiBme imBMe Dane Tes dese an ested var face sfiticnt at 55 (1) or 15 (+) Toven 63 000064 NOTOX Project 242553 TELOMER ALCOHOL/TELOMER ACRYLATE! aE PFHS/PFOS Bhs. 4 09-DEC-98 BFOEDMYALWES EI(GRGAM)HSUTMMASRY eewmes OO Jr-- wgSowir:r: wHWomaE: Toaoopees oes Gwuees rogues wwreo1 roevmmw oma Nem OE ow m mEW,ms aBym, i : Bh : BmsW i7use } aororseo3mem woomoomm,s {mBs ,ime o:B m B:awe owess eei me :w om ow 8om, EimeL imfsh m6e oawrog1 evems, w o: mw omi m hRaBe, aBeh 5a e oorwow1 3eoemm, w E i w Fh oiRme a iBe w:Bl mi5e owreppeeiwe 7mBoBwGs, i3aw B3omy m Bs m3ih oawrommem:oes, :m oomm, aiae R,m owsh0h o:0m wwoomm woi mme w 3omc omR 3 B a3w Hm3s m Bs om3 wweonw vo3emme ow7m oiOmB, BaiwW Boms oBma imo --To-----ou--metre-Ttestrbasts otn pteelerd varrtanncsrsgamfti-cantnat-5%n()mor -1% n(+)mlovned ieme 64 000065 NOTOX Project 242933 TELOMER ALCOHOL/TELOMER ACRYLATE/ A PFHS/PFOS. BWG-SUM - 1 09-DEC-98 -- MBaOlDeYsWE-- IG-- HTGAIN(1-- ) SUMMAR-- Y ---------- ene BEGaerai TwAohcrem: Gosaarewdre Gur4 GwPsenGOR wor i1 iFewh Soue FoyEseim M i i or semiWe i Bow PneOiwF HBuiiH wwwon Fieme s0i Wor P1 eiOmW "iBa wwwoez iOemF 5iB0 e WwPomeiFne 5Hia Wwr Pom Oiewe aHioe 00i0 i.Be faGo o Boie &Go o iui uiin f in odiun 01i B i Hi =0iB iL 1 nn1 n i 0 H ai 0n=i B i R=i 5&i biy aionni @iTe s7i iI) "If)o s8i iHaA D Pi 5ain iF 2 Ei"W if5he 5Bie =6Hys =i$e P3i i5Ba 0i 0@i iBoo 5 oifa f+ + Dumett-Test based an postedvarface stgnificant at 5% () ar 1% (+) level es 000066 NOTOX Project 242933 TELOVER ALCOHOL/TELOMER ACRYLATE/ =. PFHS/PFOS BHG-SUM - 2 09-DEC-98 MBAOLDEYSWEIGHT GAIN (%) SUMMARY recovery G(GEoipLnie Woyi1 niSeome. 759 wovx s1 ewvsow. a@7 Worx 2seVsmo. `2s . worx 2neVSwo. :ana wwoots WSehwe `so worx T1o VSetwow 8o"i worw O meS Vw 357 wovx Saos wWSe e 2109 worw 4meWSme 3105 GAmOoRReCI TAGGoOAeRTsIE GORA FGePS oGePs S &5= 3as a8 7` 4 I ] ins na2 `7a nas 7` 3Bne 3oa 3fe 3Es 3"fa 3o5s 3u soo 3 `l7e o"me "`Hs Bna aBs f"is aBs e &fa ndes fPYa nBe &dnee B0e nBa 1a 3Sne 3onu 3ons129 37m2e 3omHe 371032 3ias 3Ppoid 371061 [5wxeoomos "1+: Dummett-Test based on pooled vartance significant at 3% (*) or 1% (+) Tovel 66 000067 NOTOX Project 242933 TELOMER ALCOHOL/TELOMER ACRYLATE/ Wa PFHS/PFOS BWG-SUM - 3 09-DEC-98 BFEOMDAYLWEESIGHT GAIN (%) SUMMARY ener uEGrnhi wWMoEEsSR: sHSorSSs ead mmusomors Bweol wB; ee BwoesioeB we Bwrl wiowe BwoPn wOB Mwe BwoPs oOweB SAe .b UE b. .le .30 cbe 4L vow:ho. owod .owolws wsukL b aFE b.SE l;h ;kb` BowwH oooR wm oH ooww ooon wwoHwou ow wu B moB w BwmBB woR m wWPp eBBwe wWoPm wBB we WwoPm eOwF Bwrrom i;wowe oN Fm oB rom omR own eom Roomw Woouwu oDwm onwBom oB omw noomw noR m uome D wom ooB owwooowmoBhosw owh Won wwe oB A w Hwm Oomn m B ES m n Omon TT neeTar and on pated etre strict ot 6 1 or 3 7) al po 000068 NOTOX Project 242933 TELOMER ALCOHOL/TELOMER ACRYLATE! PFHSL/PoFOoS BH0G9--SDUEMC-- 984 BFOEDMYALW ES EGAIIN(G %)SH UMMATRY RECOVERY @VCOUTHCPRL1LE GALTOCEOLPHOOW?LR ATCGeROLYoLPeAIRTE GOW4 PrGiOsPS GEOdRE oWarE 11 eSTmOR. 57 237 717 2he z5n0 1&51 N 6 [ ov 5Nr mNem a5 4 ai s 3o5s s 3 3& 1 7 7 oWri 82 eSNTmOR. a75.0 5`.4 32 5 "5.7 e 2 s7 a oWrE 12 eSNTmOR. "7 2 "a6 p`6x "5 1 "7 2 77 2 WoaEr 21 SeNTmOE. a s 7.` 8 5a` o` s o6as. aH O Woaer 31 Nestmom. i3as 3750 3i"s 3"51 3"6 3a10.3 WorX m4 emSTO. 520 1 5ed F6E)2 a37 aols os N 3 3 3 3 3 3 WorE z4s NmSeTmO. 13527 Fy5s 4 533 8 =23 8 273 6 03.0 i WovE 24 mSNeTmO. 53i6s 5ps l 53300 5s30s 32a i32ts ": Ouanett-Tost based on pooled vartance sigafficant at 5% (*) or 1% () Tevel 68 000069 TNOETLOOXMERPrAoLjCecOtHOL2/4T2E93L3OMER ACRYLATE! PFHSIoPFOS FC0-S1I-MWR--951 MFAOLOEDSCONSUMPTION (G/ANIMALIDAY) SUMMARY TREATENT GCVOoECpLEi TGAOCEPHR? AGTCROROYRLEAIRTE GUP4 prGiOsPS PGroOs s eomss 11/82 vVSte.omgevw. 2 i2` s `i7o [i3o ih24 :o7s Wonss 28013s dVS1e0om8.w 224 7 @:a :nos `ols :721 his Wokssi3s4.. TNEoRie.e 34s ii,s :is 2:Fs `iz 2:7 i| owsx 24.2 MNSEooMe.w 524a i3i s a`1 sh2t4 :=is :3a0 OBVEEARN TOFREEnAtsT rea CVGoNEpLCi MGTEOCOPeLZR ATGGeROeIPArITE RAP 2 oGUsRPS PGrOosRE = "1+: unnate.Tast based on pooled variance significant at 5% (*) or 1% (**) level 69 000070 NTEOLTOOVXERProAjLeCcOtHOL2/42T9E3L3OMER ACRYLATE! PFHS/P- FOS FMOAOLDESCONSUMPTION (G/ANIMALIDAY) SUMMARY -~---.e-- RecoveRY \CGBAoiRpnLie oAGOCePLr: CATEGOoAPeTSRE - owass 1isz MNsEtMierd. 2F2Ss 22 @2ie Woszeu VEstmioo 2ie 2is ai: e Voesse2t03s ENSTRiORd. jE1o Eiy i = i vWmss1309s.m wVSeTiaOeR) ai= izo =2 i EoKs 24228 SvVetime.o a1= 2=i @wio BOEVAENRoRFEdCeOaVrERsY wer GVCooEopLi GATEOCOPEH?R TAGGeORYeRAnITE o = GORA pGiPs S 7T2s 2o3s a22 0 i2 xpol i i aS 22 i i i2 iz= GOP4 EGSORE FC0-1S-WiR--992 FGrOasRS 2o2 r o2 o z2 i . i zi4 #GROosRE FY 1+: Dumnatt-Test bused on pesled varfance significant at 5% (*) or 15 (1) level 70 000071 TNEOLTOOMXERPrAoLjCeOcHtOL2/4T2E9L3O3VER ACRYLATE/ PFHSISPFoOSo F0C1-sMAR- -993 FFEOMOADLCEOSNSUMPTION (G/ANIMALIDAY) SUMMARY --e- TREATENT CVGTeoRlpLai AGTcOEoPome?Lx ATUReRAoITrE GORA pUriPs S GproOs R Wokss 1L2e vNSeiTmoOs) 045 11h 2 12 1o: s `ixs :o1s Woesexs'a2tlss EvSTai.oeov.) 2i4 s :2o,s `11 :ons `2ia o1: s woesesiasiem SvbeTomORw i74 s o2 s zinz &2f} 2:is `ioWowEs 24 ENSiTmoEs.) 4"i2 :Ind `i2s os `=07 oPsR OBVEEARN TOFRheAeNsT em CSBOiMpRaOi:L AHGCoaOePHs? AGTGAeAPeTSrE GUP4 GriPs S #GrOosRE 2 2 u zn z 1 "1+: Dunnett-Test based on pooled variance sfgnificant at 5% (*) or 1% (+1) level 7 000072 NTOETLOOXERProAjLeCcOtHOL2/4T2E9L3O3NER ACRYLATE/ PFHS/PSFeOnSg|? FC-O1S-IMMAR- -994 FFEOMOADLCEOSNSUMPTION (G/ANIMALIDAY) SUMMARY -, RECOVERY VGIuCPEi CTRL GATLEOLCO?WLR ACTGREAYLLPOAIRTE GORA GprOisRS GPrOosRE - oWesak 111a2 EST.M0ev. ou To 22 x1 2oe a 02 Nios 2 2 2 2 2 2 : WavEs s2 e MSVETMoOEwL 02a2 xj2 y n02 8 x12 2 22o's 2o2 a NWeYaSrs121139 MSVTE.MoOEVw. 2B1 s 2 i z=in iBS =io i= MWress1397-422 SbETAONEL Nios 1 2= i 2= 22 2= i i i 1 i avs 228 BEA 2 2 2 = 2 1 Nios) 1 i i i i i J bOeVEnR ORFENCOAVERSY GVCoOIpRCOiE @TALOoCOePHOR2L ATCReRUYoLPArITE GPA pCrOisPS PrGoOsPG ve 5 = 2 =n 1+; Dumnatt.Test based on pooled variance significant at 3% (*) or 18 (+) level 72 000073 NTEOLTOOMXERProAjLeCcOtHOL2/42T9E3L3OMER ACRYLATE! PFHSIP~ FOSTM . "(RGE/LKAGTBIVOEDFYOWOEDIGCHOTNISDUAMY)PTION SUMMARY MALES - TREAT VCGEoafpamie TAGcHooOpwR:L -a oWess 12s wVSteieneor.) 4pan7 :32 VowEsS s2/i3s ESVATLo.w 1@5038 1:303 oewassissiem WSNeitmgeh 4a 5i s | wowes 24228 vSVteonieve. "a4 s 5i`t BOEVAERN OTFREeATwIEsNT --_-- wean GBCoRipGniL: TAGLOoCOPeHO:sL 102 100 A@TGOHAPOTIRE GPA :u3s8 h213 1:2038 1:2032 55: 2 *5i "3: 4 i24 GTAGOoRRAeITE GOP4 0 100 pGriPs S 1h7m1 1h2081 2:as :6 GEASPS 100 ROF1C--SMUAMR -991 GProPs E 3u: 7s 11`054 55: "e:h GprOoRsGE 108 FS ---- +1 ++: Dunnett-Test based on posted variance significant at 3% (*) or 1% (+1) level 73 000074 TNEOLTOOMXERProAjLeCcOtHOL2/4T29E3L3OMER ACRYLATE! PFHS/JPFO.S (RGE/LKAGTIBVOEDFYOWOEDIGCHOTN/SDUAMY)PTION SUMMARY MALES Recover VCGOoNGTpR:OiL ATGLOeCOPeHOrL ATGCOReYPLoATE Wouerss 11182 SNMTeiOaoRYs.) T0s 2 0uss 2 aor9 2 WoeS 2Bu dSeTm O Nis) "on 2 i07 2 26 2 WOENSS 1241-319 MSETROYRY. No) i1d. jies wio EoEsS135/4m hSTe.m0sEV. Nog) 1a iBS o i woresam?as MHEAe z "u Nios) 1 i i BOEVAENR RoFECpOeVEaRYs Cem CVGOOONTCPROE1L ATGEOCEPHR? TGAOGeRRYLrIATE " n w ORS EGSOPS -a1 aos 2 3 TM58 2 01 2 inj= i8 nI 78 i i @@. n i i GORA PGriOs P RF0C1--SMUAMR--952 GPR78OWS 221 a02 2 i7o ijas inra pGrOosRE 1+ + Dumett-Test Based on pooled vartance sfgnificant at 5% (*) or 1% (7) level 74 000075 TNOETLOOXMERProAjLeCcOtHOL2/4T2E9L3O3MER ACRYLATE/ PFHS/LPFOoS ROFLCWSR--993 (RGE/LKAGTIBVOEDFYOWOEDIGCHOTNISDUAMY)PTION SUMMARY FEMALES eA CiGOoNaTpRrOiL AoGOCePLrz ArGCORoYRLeAITE GOP4 GwnPs s GprOosRS moss d1isz wVSe oom.w 141038 1100 :5109 :b10d8 wuss mily voaersm 3813s d51emoe Vow 421044 1i2085 1:0"a7 1:p0e7d 1:2009 :o10a3 wosm1a5. vVSeiomdme.) 116083 1:078 :5170 1x08 :5107 i71050 wonxs m4am NSeoimed.) fe0n `5102 i21088 :a101 10:hd8 :osss VOeVEnRt ToFREvATeHEnNT vem CBGioNnpR:i ATGCooOepRs:L TGAeOGReRMArITE GuPs PGsos bGrOosRS 104 104 07 1s 108 102 1":Dummett. Tost based on pooled vartance significant at 35 () or 15 () eel 75 000076 TNEOLTOOMXERProAjLeCcOtHOL2/42T9E3L3OMER ACRYLATE/ PFHS/FPFTOS RFOC1--SMUAMR-- 994 ("RGE/LKAGTBIVOEDFYOWOEDIGCHOTN/SDUAYM)PTION SUMMARY S FrEMrALES S i e --e E te RECOVERY VGCoBTpORiEL @ATLUOCOPRHO2RL ATCEGRLAYOLPEAIRTE GORY PGiOPS PrGoOsRG Woaerss 11182 MSETAOR Nod 31038 2 212074 212047 51032 10182 2 2 h1a0 2 : WoaXrs 2a1 SVveTimOoR) o92 z ao2s7 iEso 2 2saso Ho2z 238 WNYeSs1241139 NBSTE.Ao0N6Yw. 1%>. i 2 abs p"o -. i i i i WoEsS13914m bSTEOR. Now) 2= 1 2= i oLL i 8= i = i oosA i oars 228 MEM nt 5 a " - { Nios) 1 i i i 1 i VOVAENR ORFECOEVIERSY ew CGVOoNUTpREOiL AGTLUCOOPHEOIL ATCGEROYELPARITE WPA EGdUPS PGroPs S 0 5 4 Cl " El "1: Dunnett-Test based an pasted variance significant at 5 (*) or 1% (**) Tove 76 000077 NTEOLTOOVXERProAfLaCcOHtOL24/2T9E3L3OMER ACRYLATE/ PFHSS/PoFO-S HE0M9--SNWov-.981 AHFATEEMRATOWLEOEGKYSSUMMARY r MALES ee eees --e ------t ea-- TReAENT WGGioTPnRLe GTAOoOReLI GfARPoMATeTE GPs s GPS sGps _-- ee ----- HeUToLoGY PAWETERS [k3i Nseaow. 1o'm Ioenmm mon wSVnoe 9oi1k soisd wirn rWSeLnO. a0i)o4n7 goIowss wuv eiSwoe. iisie umf4e wToa aVSLE. o19)wms oaLomn wmooei eSW OmE. 00244 Imand3 w3on aST0ey oZ&se IomFo apnues ESowe. w03e i1af16m . moeh vNSeDn. 3im53 2im50 sei . wiSeone. o9oeam 4o0dadm . eio. weVSato. oi0)o0r ioooonn w e. VeSTmO. EKoo)oom 0o40w0 w!o, IiSeto. oio)uwss ooieomn eh n SNeome. EKoo)smu o2o4 os oeImm Eoeynm kioehm i8es% 0o47l oo3es sh4sd aoisl 2oo4samn oo9)own bIoomwc kboi)oms Imid r s3xm3s ism8a ksiyso sioeym EloF)own bILoawg jbipaese m5Ie ima Iomia 0)mg 2am2 mF0y3o omiFo ofmiso i1w58s wi5e im06e i7um 2id1z 2wi4r 3ia0 02i77 ioomw iboorm. oIouhe boI)ouk 2ooorm iso0o0o iboeemr F0bS.e0s0s I0o0w% oo9)oomm ooIoom ooioom ooi ma ooioopm eo2olss obieosms iopaoy EFoo)essm. Icbaaws ooa)oen 1":Dunnetttest based an pooled varfance $10. at 5K or 1% level. +: Steel-test stg. at 3% level 77 000078 TNEOLTOOMXERProAjLeCcOtHOL2/42T9E3L3OVER ACRYLATE/ PFHSfIPoFsOS HEM-SUM - 2 09-Nov-98 HAEMATOLOGY SUMMARY MAFATLEERS4 WEEKS TReATENT CVGOEUMHPRGOL1LE AGLTOCEOLPHOORILR ACTGERLOYOLPWARIT.E GORA EUSPS GPrOosRE HABIATOLOGY PARAETERS sotre VSeaTnE. 019)69 11034.0 0F1y69 0f1y8.4 o5whae 01w6g sercr eWSenv. 1o136b.1 1b416a.0 2i711 iiemya 051688 B175a "1: Dunnett test based on pooled varfance sig. at3%or 1% Tevel. +: Stesletest 31g. at 5% level. 000079 78 NTEOLTOOMXERPrAoLjCeOcHtOL2/4T2E9L33OVER ACRYLATE/ PFHSSon/PFOS H0E9M--NS0WVM-9-83 HAFATEEMRAT4OWLEEOKGSY.SUMMARY FEMALES Tene GaTuRPELL GoMaOerLrr aGToEveSa GPs GFsPs wFaosre HABUTOLOGY PARNETERS nkicd rCeRn E RiiRm Aeimt S eim Esie ei+ sAc ea i : m"an rSWeTnO, 90i13 eoEysss exis fg2o0s ioosrt 03is i Kwenr eWSaoe. 0wi.9z7 o0kyw.3s50 0o%.o3n0 0SI.o37w7 kgob)sasy obfiodns i wnyl eS one. b21i 5 miie mi30 Eymii E)s2%a siio wfoon eSWwe G1ky sd roiwsss vLi ea bELS)easw rbieums oirauns wmen eSN owe. w0io mhioe m8i3 mokyss fim83 a oaii on reS nhe. omide bxEmyz 0io'me m0ia 0ioma 0ofim3a paners eSN ome. niime m1i5e ui3se inuie FywFs ikuttw . Poid eSnoe. fi7241 7iFyes m2fn3 7iEy6e he6ids s2is4 i sen eSV one. ooiomm ooiowns ooEayo kcoK)oomw obioomw obkyoom : { vSNeome. ogiooow coioow c0io0w ociooun ob'ooww boiioooos w! o. eFowe, ooimoe o0io6mm isoomoem coEyoown cbi'ooww o5ii0o0 who. eSi owe. ooinolmi koog om ooi'oym kocK)eomw soioowm oo3oomr ei n eNSome. iioomms ooi)wosu Bob)sows boioewm isobosw ooieosm "1Oumetetest based an pasied variance 13. at 55 or 1% level +: Steeles af. at 5% Tove]. 73 000080 TNOETLOOXMERProAjLeCcOtHOL2/4T2E9L3O3MER ACRYLATE/ PFHSa /PFOS HE0M9--SNUoMv-- 584 AHFATEEMRA4TOWLEOEGKYSSUMMARY ~ FEMALES -_-- TREATIENT @CVOEONHTIPRCOL1LE AGTLEOCLOPGHEI?RL GACTRePYLLMSAeTRE GORA pUriPsS GProPs G ---------------------------------- HASMATOLOGY PARAETERS osrec STNe.a0ev. h1a5).4 uw 1056.0 i 01..0 1 0H.5c 1 0w.3s ES a04ge 1 erserc SrTNe0aEv. h115o.y9 0115.0 01158.7 0305 21i6..08 21167.5 1": Dumnete-test based on pocled varfance s1g. at % or I level. +: Stesl-test sfg. at 5% level. 000081 80 NTEOLTOOMXERPrAoLjeCcOtHOL2/4T2E9L3O3VER ACRYLATE/ PFHS/--P_FOS HE09N-DSE.C.985 AHAEFMAT2TOWELEOERGKYSSRUEMCMOAVREYRY MALES TREAT VPNoRIlL: GTAeCMeOPrH? TACRRoWYLPeAITE GAP4 pGriPs S #Groos s HADHATOLOGY PARNETERS Riec nSNeowe. o37i2s8 037.%04 os na 7o3.0m0 o63 n7 o730n1 moll eSWTmORY. 9os.h1 5o3 is ao3 7s o3aie 8o3 6i 00s s3 weinr SeTNonev. oos oa oos dso 3ogodw oo3 uorl g3ooems oasdoees w"v SeNTaOne as5i.7 35i1.3 03%5 5o.s4 5156%.3 s310a fvaocit SvTWe0emv. o31o2 o3128w0 31o2o9m 31oms 3zoowm 1o3 aomn wmcin rSWeome. 203%s 2350 2303s 20 3s 2303s 32oss won rxSeaoe. 10s %1 10s8%.7 o31s.4 3153 h31o4 03m%1 poahTEErs vWSeenv. u130n6 10150021 1i186 1"3000 12088 a107 waic wSWeTonev. 5oiss 1832.40 253 1 13282 3o2s4 n9)e sia rSVeome. oo3 aoz og3 oasn o3onos ooomles 3 oaoue s 0ooam s i . eNSaoe. eos mss o0s o0ms oo3 osm oDoomm 3 oaooms 3 so0.o00m8 aYso SwTWe0neY. o93 o%o oa3 odnn oo3 4wm oo3 oon 003 0%m 0bs.o0w0 wo o, SeFW.n0ev. 3ogaons c3oooim oo3 sa oo3 oom oo3 owm o030o0ms wi en. eWSone. Q3oosss oo osm oo3 moem oososm 3 oosny 3 0ooam s *1*: DummettTest based on pooled varfance $10. at 5K or 1% level. +: Stesl-test stg. at 5% level 81 000082 TNEOLTOOVXERPrAoLjCeOctHOL2/42T9E3L3OMER ACRYLATE/ PFHSI_PF--OS HE'M0-9-SDWEC-- 986 . AHFATEEMRAT2OWLEOEGKYSSRUEMCMOAVREYRY MALES TREATY GVCOBUMUPRCOIEL TOALoCPwOHeIOrL TGAGLORmYPLEAIRTE GOR4 PrWiOsRPS GPrOoRsGE HABIATOLOGY PARNETERS serec eSN7a06. o316l.6 30155.2 0317s o31f6 o215d.2 031555 esrer eNSTa.oev. 13pe6t.2 301s3. 11360.0 13330 0215.2 u13 %r "I: Dunnete-test based on pooled variance sig. at 5K or IX Tavel. +: Stesl-test sfg. at 5% Toval. 82 000083 TNEOLTOOMXERPrAoLjCeOctHOL2/4T2E9L3O3MER ACRYLATE/ PFHSIPaFrOS HE0M9--SDUEMC--987 AHFATEEMRAT2OWLEOEGKYSSRUEMCMOAVRERYY _FE--MALES TREATENT _-- QCVOIPMRaLOEL TAGLOCoORHeOIL AGTGEORLYOPLNAIRTE GOP HAMATOLOGY PARAMETERS pGrOsPS pGroPs S TsTc wSeNT.a0nev. 370.0052 o63 l4s7 3o6m6 3ossnt 03Pr 3 o6i533 3 molt rSeT.oev. N 02.10 3 oaze 3 0073 3 o5.t0 3 oass 3 sois a wner STe.a N o04s06 3 3gooess 3oolbdiz 3ooomrz oosws 3 ooosme 3 |i w"v wNSeoanv. 0557.5 3 35h0a.4 s32e4o 3272 732.19 a09.63 twoean NSe7a06. gLo r 3 3oLoams 3oas0s 3oLoamw 3greanm sosaoe wmeoell sNSeTnORY. 23 e2y 023 4 3o2i3 30246 3o2ss 3o2.d1 r*ow weWSaone. 3w5s 31o5i.2 11353.4 3L157.3 3i10i6 3o15i.7 ! oPnLATELETS SMTE.A0ev. N 1126952 3 j3oresd f3e1066 53uu 1o3 5e 321094 : aeic vNSe0n6. 3i73s 3207 3373 6173 3T6so 325185 seia. STNeoaev. 30o0s7 o3ooomm 3ociose o3ooomm oo3 ow 3o0oam 1 wNSeTOnRY. 300000s8 3o0.o07 3ooeiss 30o0o0os 3o0o0ls 030..000082 450 SsT.e0wRy. N o0.0o00 3 gooowm 3 00.00000 3 Dooomm 3 oooomm s 03o.o00m0 s7ow, SeTNoaEv. o3oooere g3ooow 3oooor | 3Ooooim o3oool 3o0.o0m2 iwen. STe0mEv. N 0o3 5w0e 5oooemm 3eomms o3oeomm o3oswm 3ooeomm "17: Dunnott-test based on pooled variance 1g. at SK or 1% Teel. +: Steel-test sig: at 5% level 000084 83 NTEOLTOOVXERPArLofCeOcHtOL2/4T2E93L3OMER ACRYLATE/ `PFHSSIPoFO-S HAEMATOLOGY SUMMARY AFFETMEARLE2SWEEKS RECOVERY TREATENT BASMATOLOGY PARNETERS GVOBPE1 CONTROL GALTOCEOPOHkOLR ACTGREUYLLOPARITRE GUP4 EGyORS seeTc [sTN=.oev. 1603.40 03w4s 10s6 3 0"3et 3 moiec 2 erErS [ST2O. N 3125..65 01..34 3 31n5i.1 01.s8 3 151.37 2 HE0M9--SDWEMC--988 GPrOosP sois 2 01.80.7 2 "17%: Dunnett-test based an pooled varfance sig. at 5% or 18 level. +: Stesl-test sip. at 5K love] 84 000085 NTEOLTOOMXERProAjLeCcOtHOL2/42T9E3L3OMER ACRYLATE! PFHS/PFOSe HE0M9-SDWEC-985 HAAEFMAT4TOWELEOEGRKYS SRUEMCMOAVREYRY MALES Reamer VGCOouNTriRO:eL TGAaLooCreL:R TSAGhMRYoPArsTE GORs wOsRs bGiaosre BUTOLOGY PARNETERS nkic rWSeaoe. o13 ss to: ww oels ro3 on eo3 ma osees m"an vSNeone. 203 61 02321 323 31 9o3.a2 35a0s 5a3.20 wewnr eSWnoe. 3osmss oo omm. oo3 omm oo ems oo3 mee 3obemn t w"v rSNehae. m3ie o3mia 3sima 3s8ma 3sjesr s3iml n3H eVSwDs 1g e2z6 g3iwa d5Loemm o3 oanr d3wers tds eanm wmeein eVSOwE. 30081 3m53a a3m4e 30m%6 m05 7a aIs a a5o eSW mev s0w4s 0so%mer 3xma o3mese 3n5e x3137 PaLnTEETS eNSone. 103i02 5ws id"s u3Wwm faw3 s 3170m Ia mWsno. 03m%2 m55 0s h3moe 3sias 7J3 7 33142 si a IsVeto. 0o3 1o8 s3ooomm oo3oomm. oo3 oom 3ocoome oos odme eio wSNeenr oo3 osr oo3 moe cc3 oaws mos osm do3 oors oo oono w? e. EWSomm. o3soao 3oDoww Sc3 ooww o3daowm so3 oaow d3oeoe . 1w! o. eWStmo. og3 oos oo3 ooml o03 o0n% oo3 oemm oooomm oos oemm wi en. eiSome. oo5 sem o500m% 03o0m8 o3oesss b3oesss oo: mo "1: Oumnett-Tast based on pooled variance 31g: at 5% or 1% Tove). o: Staan-test stg. at 5% level 85 000086 NTEOLTOOMXERProAjLeCcOtHOL2/4T2E9L3O3WER ACRYLATE! /PFHSIPFOhSa HEM0-9S-U0MEC-1508 AHAEFMAT4TOWELEOEGRKYSSRUEMCMOAVRERYY MALES Tene TVCNEER TTACoOEWkL TAEGoYeArTE hs Pros HASATOLOGY PARNETERS eSro eSN ome. 021.%1 10234.0 mo3 he wiz e 07 52 03140 e4r =SV oe. o21a0 o1O25.2 360s 0216s h21e.s2 23156 "1: Dunnett-test based on pooled varfance a1g. at S% or IX Teval. +: Steol-test sig. at 5% level. 86 000087 NTEOLTOOMXERProAjLeCcOtHOL2/42T9E3L3OVER ACRYLATE! IPFHSIPFOoSse HE0M-9S-U0MC--9181 AHFATEEMRAT4OWLEOEGKYSSRUEMCMOAVREYRY FEMALES eA GVGoEIpRGiL: GTAlMCooPRr?L| GTAeOGoRRYeAIRTE GNP4 orGsUPS GprOosRE HABKATOLOGY PARNKTERS wocm SVaF.n0ev. 3c4o si3 o] 6[32m 6o39n9 3608208 6o35i6s : man eNSmo. 903 13 90.24 a35.20 pe9s]1 i033n o03 7s weSir esW ene. 0o3 8o7m so5 laomr oO3 mo soOom oos omm o3ooed wnv e5N 0nan 57 s8 3j7d 72.54 53365.2 53574.2 533 58 weToir wSNeEnoev. 31coam 1c3 osls 3toeemm Lo3 wm d3noasu rg3 aoms wmeail eWSTmORY. 23he)4 035%3 2o3.u1 x31; 203.50 n03 s won SrTVe0aevr. 1I328 031%.5 031513 103286 31pe5s.3 0315s PaTnELETS eTW oae. o53m 53i80 91326s 3oom i3n s5i94 woei sSeaoe. 03c8o oi3 ts 3377 6o: 2l 623 s3 83273 si o seSWatne. og3omsat 3ogeolms eo3 oosl o3oeesm od3 oonn 0o3 0omm eio weSNaone. og3 ooml 0o3 0ss oo3 ooo oo3 okm 30oo0m 0D3 0osw as?so. aNSoe. o0 0o0 o0s 0o0 3ooomo 0D3 o0w g30o0o0 00s.006000 w o. ESN twe. sg3ooess sooow og3 moew ocoooe eD3 mosw o0:.o00m8 wTenL. eNSomw. o03 s0s2 0o3 0s oo3hsimo oo3 aens od3 omwe 003.s0wm "1 Dumete-test Based on pooted variance sig. at 5K or 16 level. +: Steel-tast fg. at 5% level 87 000088 TNOETLOOXMERProAjLeCcOtHOL2I4T2E9L3O3MER ACRYLATE! /PFHS/PFOSva HEM0-9S-U0EMC--9182 AHAEFMA4TTOWEELEOKGRSY SRUEMCMOAVREYRY FEMALES meme HDUTOLOGY PARNETERS Soer ovSonw. e&r eFowe. RVoipLeit ATwChoHerRe:L TAGRaoAreTyE Gaps pmusrs Ewrooses 3a26a 8bm%32 awis moea 30u3g 34na 31B370 owse 3iBr 3IBo $o1fa 3ius "1: Cumnatt-tast Based on pooled vartance sfg. at 5 or 1% level. +: Stasl-test sig. at 3% level 88 000089 NTOETLOOXMERProAjLeCcOtHOL2/4T2E9L3O3MER ACRYLATE! PFHS2 IEFOS CH0E9--SNWOV--981 CALIFNIC4TALWEBEIEORKCSHEMISTRY SUMMARY MALES TReATENT GVEoHIpCLiE CONTROL GTALEOCLHROIEILR AOCTRePYLLOIAwTRE GORA EUgPS pGroPs s awaattn ENSFm.0ev. 001..162 001..1601 o0i.e61 o05.n57 001.6%7 o01.s06 arattihn) vSWFe.moev. 021..3880 o2Fa6t2 o2ii5e8 021:330 0a1.2m6c a014.m4 wmoritt SeT.m N 2i u s21 21 1 21 2 2i Bl i rceaollls. STMNoeeav. o2uw.s00 01i4a4 L0i4a7 o11k7 001:.29070 ao1ske reaalLli seSaone. N 0014.280 001.268 o03:3m8 0oi.a6t5 ooIas ox1dds REiAThINNE MSEoAeNv. N a`i 3i a2i 4i @51 s12 eoeuowiclolse dSe0a6. N 6a572 i s0.d9s5 sau5 1 Ww i6T5o9 A1a R 6T.3a8 3 rewearl} SeTonev. W 6j9d i 7L.o0 i 6171 i 6io BR 7175 i 71.26 1 PaRnOTEIN T. MSNEoANe. i52W.50 si2:W4 z 2si5et m2W2ec 2s8 e i s2:0 ens i Monaan wSWTeoaev. 0Ww.53 ii7d 1i73 r1as 04.0 1 2ha. i canos sNSeome. i72w55 Mhiaas 2e10r Miisos hBaIL i 22ia i NG RATIO MSNTe.ev. o13r1 o1i2 0 o1t2s 1 o1i2. 3 o1i34 I o1t24 wW aekart rSeone. N W7i7m6 W8Iw.0t8 7Li.e70 8ii.i0s0 915880 7ii2i8 "17: Dunnatt-test bused an pooled varfance sg. at5Kor 1% level. +: Steel-test fg. at 5% level 000090 89 NOTO Project 24255 TELOMER ALCOHOL/TELOMER ACRYLATE/ -- PFHSIPFOS oes- 2 09-NOV-98 CSaLIgNeIeCr4ALweBEIOknCsHEMISTRY SUMMARY nner arGurrte: mor: AR mors wwes dw meoors ewes EurRprOoseSrv e. 1R e m Ow Rim waMmE 3iwemB s3owm% aimm sH oor OER N A 14Mw2.6oCoW42w.9 oom 3.w2 B o1w3.0owo13w.3 1oo4wu2.9 : rWEom vBonh wSe REee a$mB a4mBe oimm sias W owenOW ev n AonEoEnoe iveWma 1R w9 oE eae wAo on3ow MaoweEm aw0 oe1omm aamm wih m ho3 m iwLe u3ee 17 cnet tot and an sadvi ane +1. a 34a 16 evel. 45 Stl st. at 36 lw. 50 000091 NTEOLTOOMXERProAjLeCcOtHOL2/42T9E3L3OMER ACRYLATE PFHScIPF-OS CH0E9--SNW0V-+ 983 `ACFLTIENIRCA4LWBEIEOKCSHEMISTRY SUMMARY FEMALES TREATENT GVCOUONTPCRO1EL GTALEOCLOORHMOIRL GAGTOREVLRIOAMITRE GORA PrUiPs S GProosws ArtAhT) SENTowev. 0o15i2r 001..0457 0o1.3e5 0o45z2 001..5075 00ja.362 AsaatTl(?GT) dSTe.ev N 2bx.62 u 021.5973 02.3.24 20..3308 2 In 2[x43 4 2o.s32 1 sprtrh. eSN ewv 31i 2ii 31 311 211 31H racoluielsTT. MSNeem. 2h1emd 21.i2o6 20I.a4009 1204.332 Lo2emc 201.035 TmaIlLi rNSeT.noev. 0o1.6e0 0o1.5s7 0oa.3i8 o024.s56 001561 001..156 CoRElATININE bNSEoAYv. "3u ai 34i aqi 3i a:u roouowclo]se vSTe.0mev. N 6x10ds 501.:9508 s[1xud 6o10500 5o1.40r2 5fi.9o8 . pweer STe.a 8hl3 a14s 517 9j.i0 00s5 11052 : N i 1 iW 1 1 iW : aPiROTEINT. SMTEEM . N 3uw59 is2W8s i2W50 i26W55.2 o1f4 si1s : nIos vNSTe.ev. r1a0 IsLnae siu8 s2i2e 531.7 w11u7s caomLIN bSeEv. s2u3e s2u4o a5a 22.%4 aair a24s N i WW 14 fn 1 i NoRATIO SvNToeev. o11x1 10111 o1Ir1 La2o 1o11l o11t1 aaeent SeTn. a0i6s N 14 s01.o35 uiains 042380 p41i.06 4ii30 "1: Dunnatt-tost based on peated variance sg. at 58 or 18 Teel. +: Stesl-test aig. at 3% level. 000092 91 TNEOLTOOMXERProAfLeCcOtHOL2/42T9E3L3OVER ACRYLATE PFHS/PoFnOS A`CFLTIENRIC4ALWBEIEOKCSHEMISTRY SUMMARY FEMALES eT CQVHOPIRCOLG.E ATGCaEOPRH? TAGCOREYRARITE GORA rGOsPS mINoOlRGlPHOS WSJTEOMRY. o2I3x8 msoolwl WSeTmOR. 1iwe2 mPooTlASlSIIN NSeTOAeY. 10p4e 3 mooinllc eNSTwoeV. 2a2.056 mcuoolRoe NSvTemOR. 3ior a23l3s8 202.442 0%m:8es 0owhe oo24au oains 420.660 02I..6008 iz 9i2 o42.6i2 Io2a4t8 i1ie0 i0ea.7s 40i2 oW0a0 2o2.s60 012:.3566 iz 2i2 CH0E9--SNUOMV-- 984 G#roOs s 1o20.3n9 1ia0ys 0I083 s21.o6r0 :2ao "177: Dunnett-test based an pooled variance sfg. at5K or 1% Tevel. +: Stael-test sg. at 5% level 2 0000393 9 NTEOLTOOVXERProAjLCeOcHtOL2/4T2E9L3O3WER ACRYLATE! PFHSw /PFOSl CH0E9--S0WEMC--985 CALIFNIC2TALWEEBIEOKRCSHERMEICSOTVRYERSYUMMARY M_AL--E_S --m TATE iGGanrLei GoACweweAr:L GaAGooAeeTsE Gore mmasrs wBrooses --_--_-- ee---- AwaalTiEn SNveone. 39o%e oo3 ke ooem 3oomh oo$ mR o0s sH Awaalrion eSme 32as0 ad mh 3d2am 2:omm 23aes o51hm sERuEr ei mA : 3 3si ia3 i5s 2:5 33i cmaolsit. eSowe. 03L%s 13beg 3o1em 801sm. 8otmw 54aBm mmiai VeSomv. 00:s % 03osm oo3 mm 3ooml o3bee o3omR cwenre euWwhe = : 2i =23 73 3 55 aswaonse VSwehne 5asne 3feem 5oemm 3aonmc xo u 3e1md wmairn wiSone. 3c5e8 73a33 3e6s7 ssoos oa7 7a8 47 OotTE T. eS ear 3mis mi3 esc 83m5e 3me wa3 r assm7s Moiaan ipSeone. 5m6o 3mi5 moss m3ia. 3mis smoly aaron eSi hwe. 3m30e m:I)e 3Ioma m3feis 3o5me mI3 a Nom VSene, a:1l1 3o1d2 w1o0 3o1i1 o81i1 105 1s uweeen eSN one. 3e 2e es3re 3ismm s3twe o3emm 3siea 145 Dunnetttask based on pooled varfance $13. at 3 or 1% Tove. +: Steel-tes a1. at 3 level. 93 000094 TNEOLTGOUERProAjLeCcOtHOL24I2T5E3L0OWER ACRYLATE IPFHSIFFO-S chFeRs.A6 `MGALAFITLENERGSA2LWEBEIOKCSHERMEICSOTRVYERSYUMMARY emer E GGoirniRMwSwoem: mors mors one egooes wmwes T[O--N--V . = ow O ven mroEss veWnhse moeEm OWVenR SowUe ivrPene E 1m HR$am a3nB aM e m$am ae $ 5M wa m3mee wae $ $wowas oans $owues $3E8 TE E m owT om am $0ne $dieu gzme m a w$1s am wo : 3:om 33ow i3om i3mmi3 1 Dunnett bad on stad va anc 85 AE 3 16 Tra. +: Soules tg. at36 ev. 94 0000 95 TNEOLTOOMXERPArLoCjeOcHtOL2/4T2E9L3O3MER ACRYLATE/ PFHSi/PF.OS CHE0-9S-WDMEC-- 987 A`CLIFNICT2AWL EEBEIOKRCSHERMEICSOTVRYESRUYMMARY FEMALES TREATIENT GVEOHIPCLEi CONTROL GTERLPOEIR ALCOHOL AGGTReRV.OLoAWeTIRE. GUP4 3GUPS pGrRoUsP AkLaTt(iET) vSTe.m08v. N ol0.o4s7 3 o0la.63 3 o03.4t9 0o.o5n7 3 0o.5z2 3 o0.o4r5 3 AkSaTt(iGOT) STb.E0ev. NW o2is.53 3 20.66s1 s 20.1s0 3 32o.5s8 o1l6s 3 02.1079 3 wBmLaT. STM.e0w8v. 13 N 3 i2 3 2o 3 3i 3 03 3 12 3 mCoHlOLlEST.T. STM.E0M8Y. N 023 136 01.49s2 3 o17a4 3 o2.m41 3 201410 3 02.8072 3 t mioGl = ST.0ev. N 00.2649 0.0.0433 3 3 0o.6a1 3 00.2763 3 300..0450 0[.0=8 s wCeREAiTININE STNM.E0AeNv. 32 3 2" 3 5a3 7 3 3"4 3ai mcoulcolse STe.a08tv. N 37i.e3s4 06.65s2 3 o73s1 3 r7o4t 71.578 3 3 o7.i6s0 3 wmeorl) STe.0nev. N 350.78 7s.34 3812 se1t 70.46 3 3 3[x 3 PiRlOTEIN T. ESNTa.t08Y. 3285.6 a3.87 3 a61.61 oa.i2 3 a6.z4 3 5"3.026 CoaMnean STEN.0m8Y. 32$.27.2 322.87 Ia)e a L2.r8 3 101.4 3 32135 ocLnoBLIN dsTe.aonev. N 33113s 22.80 3 235 3 3a15e B3:3 .1 3 h2e.)1 3 NORATIO STEN.a0t8Y. 30L1o o31z1 x31e1 o31o1 30[1s o1i2 3 kaear ST=.08v. N 3o.l3i02 s 331.1600 L4o3s jx3.85 3 3 331.2207 3ars3t "1: Ounnott-test based an pooled varfance 1g. at 5Kor 1% level. o: Stael-test sig. at 3% Tevel 95 000096 TNEOLTOOMXERProAjLeCcOtHOL2/4T2E9L3O3MER ACRYLATE PFHSI=PF=OS CH0E9--S0UEMC-- 98& A(CFLTIENRIC2ALWBEIEOKCSHERMEICSOTVREYRSYUMMARY _FEM-- ALES -- ener GCiHrnRie sATahCeeLe: TGAGoeAesTE Gwps e mwes Hups 4 mnoolklprose VeSaTtON. 302%0 032%m 3oaems aapm 3o2mm 3iaaBp msonn NSehme iw3 ee 5beh}s 0 3ie 3wifss 3owse oaes | m[aElC So. 30so% 3osme a3oems 3aowm 3owwn saonh mMoCllI WSMeon . 3O2.W6 . 2sd.e59 3o2.o57 o32.6e8 a:2.6f8 3s286 cmuims ivSeone. 31 5} :z 3"7 3:2 2i10 1 Ounsatt-tast Based an posted vartance 13. at 5% or 15 Tov. +: Steel-tost s1g. at 5% Tews] 56 000097 TNEOLTOOMXERPrAoLjCeOcHtOL2/4T2E9L3O3MER ACRYLATE PFHSIPFO-S CH0E9--SNWov--589 A`FCTLIENRIC4ALWBEIEOKCSHERMEICSOTVREYRSYUMMARY -- MALES _--m---------- TREATHENT GECHOPREO GCTOEORELIR GTAGoPAeSTsE GNP4 PGrOisP CProosws r---------------------------------------- GAaTthT|) ShN tee. 3o05n9 o30.o68 3000630 o30.i5r8 s0oi 0so6z asattiion) vWSe7m06. 3o26x5 230.4 3o2.a06 s20s99 32o.4x0 sLoeir wseulrd. SeN TmoE 31s 32i 3is 3i8 52i 230 + mcooluleistr. wNSeTnV. po3eis so1i2s0 031s 301838 30Lac 3ovra mmioall reNSTaOr. 003136 0305s8 o30.i53 3o0.o5r6 3o0.l3s 3o0.4z5 Hcaee vent N 33i% 3= 3{= a3 3o 32 omiwlels sNSeTmO. 3oa0i 73i.4s5 73i.o0s8 [p3 n9 as5 snc 3oeam EYmein vNSeEmO. 063 33 30623 6sos 73075 283 3 3o6s0 aPnROTEIN T. SvNoeenv. oa3 fa 3ossec 33m3ac 32m5os H5moa 255050 aniot sn STNv.e0mev. 032% .6 o23.s8 2i7.0 23is. 307%3 2307.5 chlom SNseoae. 03s%s 3236 32.5)4 3h.t3 23i.%0 32265.9 : NoRATIO NwSome. 3000s 3o1i0 3o1o0 03oi9 3o0s9 3o1t0 Garan weNSaor 30pe8 3562 3isa j3siea 565.00 sooins "17: Dumnett-test based on posted variance s1g. at 5K or 1% Tevel. +: Steol-tast stg. at 5% level 97 000098 TNEOLTOOMXERPrAoLjCeOctHOL2I4T2E9L3O3MER ACRYLATE! PFHS/> PFOS= CH0E5--SNWoMv--5100 A`CFLTIENRIC4ALWBEIEOKCSHERMEICSOTVREYRSYUMMARY e MALES eee----------r -- eee GVGamii ETAcoeowe:r ahGacorrede Gaps wmaers wows em eerste mere: mosacn,oros eVSaone. ds3 Wa $dahe d2E6 5 eETc 22$ 8s i3apm msonm Wehwe 3w e 3ies i3wfas 3wof ae 3wie wofr } mPionms JSeene. d3sRs 3SaRmTc SsEsTc BaS Tme s3amne i3egee i CmALiClIlUM EWAo. 5o2:o58 32a.4w8 * s32.m48 * o32.m46 23M.489 3i2.e48 * cmunm viSen efi0 1033 i3100 13i00 03i 3z07+ 17: Dumte-test based on poled Arfancn 51g. at 5%or 1% Teva, +: Stael-test ag. at5% evel. 98 000099 TNEOLTOOMXERP.roAjLeCcOtHOL2/42T9E3L3OVER ACRYLATE! /PFHS/cPFoOS CHE0-9S-UNMov--9181 CALFITNEIRCA4LWBEIEOKCSHERMEICSOTVREYRSYUMMARY FEMALES ene GiGonEpL: TAGaoGreLr TGgRuoAeeTsE Gaps [GOiPS cups eGaltn eSNome.. EoEm o2 m o3 h 3ea o3 f o: n JGaaren eS3 eme. 3o m 203 m% 03le 2a3ms@ ao3 mh oinm smauirn. eS3 emer 2i3 2i5 3i5 2i5 23 2i3 mceoisnt. eS ome. 32ds 2o sm ao Rm 2o mh 20 0% 3aomm mmiei eSome. 0o3 sm oos mm 3oowa eo: hmo 3ooeas oo3 mx cnaenoe vVSeen . a33 3:2 3 "3 3i 3i omawns eS me 73w6 ows3 s eo3 mw s3iuk eoS sd L5IeB wmern vSVene 7j3 3d 7333 s3io [3i 7o5 0s 551077 T0ENT. eSme, 3aoFs 3w25s 3mi1 3e4s ooss hieoa . noi a eS owe. w13 a m34s m33 e mi3 e womFa o23 me coiomm Sweenr m23 5e im3 e iw3 e w2i r mi5 a m3 s Nemo vSNeon. I0n0 1o8 0l x3Lto 30oso Lo fo 10 0 nSeeen VeSnwe. 0S2d8 3sImN am s d3zRm 32MmR aN mB "1; Dunnetttest Based an posted variance 1g. at 5% or 1% Tovl. o: Stael-test sig. at 3% level 99 000100 TNEOLTOOMXERProALjCeOcHtOL2/4T2E9L5O3VER ACRYLATE! PFHSIi FFOS ACFLITNEIRCALWBEIEOKCSHERMEICSOTVREYRSYUMMARY _FEM--ALES T_e--ne GCVUNEERGS: GATOEHPRL:R mDosnprose eisome. 3o13wm soInm msionn Nseome. 31w%a h3Lee mPaollms NSveone 3vaa2 3oemu EcuEeNrm NCemO 3SR32m mcoulmls NSeome. 14300 1033 1 TSAGERAETIRE mes mwses 3o1mm 3oawm 3s2a 1m77 3owFs hwte os3 em ou3 mn s3ofm 32B m a3 S m 3aeSI 1:i00 33 33102 G0E5-SNov-1523 mHoers i3aEg soisw osoa l 3a1e 3h105 1: Dummetttest bused on pooTed variance 31g. at 5% or 1% Tevel. +: Steel-test fg. at 58 level. 100 000101 TNEOLTOOMXERPrAoLjCeOctHOL2/4T2E93L3OMER ACRYLATE; PFHSo/PFnOS AOFRTGEARN4WWEEIEGKHTSS (GRAM) SUMMARY MALES -_-- TREATENT --_-- GCVEOoHNITeCRLOlEL GTALHOCLOOPHWO?RL RAGTOReYLPLOAeTRE OPA pGriOsP Boy . SeT.a06v. N a2s 8 is asis sI0gs 5076 a.088 SAIN STe.a06rv. W ol2s.o0r0 o1l.o9r6 8 01.0965 02..0080 8 01..0986 ` HART eSTa.0n8Y. n 0L113038 5 8Lii1n44 o1l5s7 8 0L1i1s05e 8 oLo1s0s7 8 Liver nS=T.08Y. 1103.405 01.06.035 8 5o.l3e6 8 jr2.00 8 1B6a8 8 KIDNEYS SeTa.n08Y. 02..3380 N 8 o2.3e4 8 021.12s0 8 2o.z1s6 8 e2o.z34 ARES STM.E0N8v. W 00`..00056 5c0.o00s8 00.000m7 8 0o.l0o4o6s 5 00..000509 5 Lea [S=T.08v. N 00..518109 3 00..056695 8 00..506675 ` o0l.o5r7 s 0s0..057m6 Testes S[T=.08v. N o2.8n7 8 o08z 5 o2i7s8 5 2o.t86s 8 2o.8s0 8 OS08-M0EC-.981 oprows s a21 5 F2X.I0I0 s 0Ll118013 8 @a1.5s0 e o2l.i1s 8 .0/006163 s 080/.053568 o2.l8s8 8 "17: Dumnete-test based an pooled variance stg. at 3 or 1% Teva 101 000102 TNEOLTOOVXERPrAoLfCeOctHOL2/4T2E9L3O3MER ACRYLATE! PFHSIPFOSers oH08--SDEC.-582 A`FOTREGRAN4BWOEDEYKWSEIGHT RATIOS SUMMARY M_A--LES 0 TReATHENT _-- GVBaICpLE CONTROL GATLOMCWOPHEO?RL GAGTREYIvLeTnE GOP owres s Pmroosws s[ orwCY eV m 3a: s 8ais i80ss :706 90) 82au s[)am seWSaTnE. 080.06s 800.028 080.%6 00e.06s6 0s0.06s 0a0068 reoynt saWS7y06. S soo 03 8ons os0omr oo: mmee oo` osme oaoauns 3v)er SrTWe.aoerv. o831t os2.x30 o3ai.07 2ao9n5 soadge 0ae 3m% e K5o)vrs STeNonev. 080075 o3ol n 08o.0n5 00: 7%0 800..0756 00e.5675 a[2ves WvTeome. 3oozo 5soewm 0so0o2n o8caons b`ooos 8oooum i s3)we STNeomev. o80m1 3w0o1w8 8doouss o:oluss 8coaues o@oesm T0)EE Newtev. 300.09s1 s0057 3a0.01 o0a.l94 3o0.n0 00e.3980 1": Dumnate:-test based on pooled varfance s1g. at 5K or 1% level. 102 0001. 03 NTEoLTOOMXERPrAoLjCeOcHtOL2/4T2E9L3O3MER ACRYLATE! PFHS/aPRFOS OAFRTGEARN4WWEEIEGKHTSS (GRAM) SUMMARY FEMALES --_-- TREATVENT GVEwHIPCLlE _-- CONTROL 8o0Y w. wSTe.a0n8v. N 822 BAI rSeTa.oev. o1l8o8s N s HEART NeSTa.08Y. Oo8s2s 8 ver rSeTa. N 05602 5 KIoEYs sTE.a0nev. p1.t50 N e ARELS STdN.0E8Y. 0Q.o0o6y 8 seen STe.a08v. Ww 0Q.4o2s3 8 owRIEs dSTe.0aev. 0o.1o24 N e ATLEGCLWOOPHRZLR ATCRERULYOLPNAIRTE 1as 6 eis20 o1l9o9s ol18s5 8 7 oloesst 8 0ol7o0r 7 a7l.s1s8 8 06.947 7 10116s o1i8r1 3 7 00.000694 s 70o.0s60 o0o4m0 8 o0e4s7 7 o0.1o33 8 o0b1ss 7 GOR4 2i0s8 s o1l5o0s 8 oososr e 6o3n3 8 011573 8 0o.0wm s oo8 ssm ooda 8 pUrPs S 1mm o1l8s 8 oceoss e oonn 8 o13z1 8 0omos 3 o0oam . oooam 8 OW0-8S-MDEC+-983 pcroos p 1167+ 8 o1lo8s s o0.o74m8 + 8 7[2.900 s o14x8 8 oooomo 8 oo8 ounk 0oaims s "1: Dunnett-test based on pooled variance sig. at 5% or 1% level. 103 000104 NTEOLTOOMXERProAjLeCcOtHOL2/4T2E93L3OMER ACRYLATE/ PFHSh/ePFrOsS OAFRTGEARN/4BWOEDEYKSW.EIGHT RATIOS SUMMARY F_E--MALES TREATENT --_-- GVEoHpUlE COME GATOLeRGePMRZL TAGeGUReLPAnITE GOP [Boevte. SwNTe.a 2ae i8sm i28s0 is2s8 BRAT SrTNeoaev. 0o8.i8e9 0s0..0952 070..0963 0.o.0t1 H[A9RT wNeSWTa.0rEV. 0sod0or o80l3w 7o0oam 0so0ssm L[i3ver sSeNaT. sossn o83.n40 o73.s19 a8 1ert o*vers jSTe.m0ev W o0:0n3 e o03.m07 p0x.76 7 o8xdm w0o)Rews STdNeoaenv. 0o8.u00s6 o80ems o7ooom O5ooeim sen NeSTw.oey. o081o9m% oo3 omme oo7 ws o8oza ouRies STNw0eEaV. 08000180 :0oo.i0z6 7o0o0m o0o0i8s e OH0-8S-UDMEC-984 PrOiBs S 1283 0x3.e9d4 o3oodk 330.33s8 s00.076 oo8 oom 8oooe o08 0ss PGroes e 1s17 8oLlootr e 3s0aamm aalss s 080.703+ osoomm 8oomo b08 .o0m8 "17 Dunnate test based on poaled variance sig. at 5K or 1% level 00010 104 NOTOX Project 242933 TELOMER ALCOHOL/TELOMER ACRYLATE/ Toons IPFHS/PFOS. OW-SWM - 5 08-DEC-98 A`ORFGA2NTWWEEEIEGRKHSTSR(EGCROAVME)RSYUMMARY r MALES eese. Temen sNVaTBrREi GTALHuCOOrHOR:L TGAeGPoAe)TrE Goes E Goes Hmes _-- ee wor. eNSome. 3=7 3iae a3ut ai3"6 32& 3i10 wan Nesowe. 3103k8 o3Lym 13oms 8eanm 3pLke 33a%e } veer IsNoto. 3oLie Lol ee S3Lom 3dLos s:Liuee 3siea 1 LIVER VsEAoN . o82m4 830.27 93i.8a9 31i0.30 93p.5E5 3M14e.07 * t KIONEYS ESAoNe. 8e2.s04 2d3.0e8 2s3.4a1 2a3.3R9 2d:.1R8 28.65 Rows vVSeone. 3ooo o soooe 3ooesss 3o0o0ns :oooens 3eoaoe se W5w0wa oc3 aosn 03obsi 3o0lsy oo emm o3oessu 3bouems TE Vseowe. 3d2as 3ozwi o3ske a3amms 1 23 a 6%5so; 1": Dunnete-tast based an pooled vartance s1g. at 5% or 1% Teva]. 108 000106 TNEOLTOOMXERPrAoLjCeOctHOL2/4T2E9L3O3MER ACRYLATE] [PFHS/PFOSre OW0-8S-UDMEC-.986 AOFRTGEARN2BWOEDEYKWSERIEGCHOTVREARTYIOS SUMMARY -M_A--LES EAN _-- VQCUNeETeR GAToPOe?Rs TGAReIPnLeASrTE GPs PGriPsS GProosws s[ ow. Er Wew 530 a3u2 fn34 as"s a ia0 sam eVSmoe. 5o0o6 0o36os 0030s6 oo3sosk 3a0lt6s 03033 ; w)ear eNSowe. o303b2 g30os o3oosm csoamne o3oess 3yoasne v)er eSNnoe. 2a35n8 323.0675 032.%06 o23 nm 3o2.n99 s3o7n00 K)ors SNeome. 03066 053.0686 30[5 ET350 30aog 3o01x0 Rows Neiw 3oooorm 3oodoems 3ovoals 3Dooos 3aooon 3ooaros [s4e NSeT.m0ev. 30co1s o3oodne 3d0e1w% oos omm osoioe 3oootme TE NeSome. 300.008 300.6%8 00.%0 300.%2 3oonm 3o0.o8t0 "1:Dunnetttest based an pooTed vartance s1g. at 3% or 1 Tava]. 106 000107 NOTOX Project 242933 TELOMER ALCOHOL/TELOMER ACRYLATE/ edt PFHS/PFOS F`OAeRFuGTAEALRNEW2SWEEESIR(GERGCAOMV)HERSYUTMMASRY ee Tener --_ GGRoeuErri GWeuEorEn: mmMoearsee wort om veeEw J;eBwm 3om 3oxm 3xow e;Fmeo m $Mi3 e wm $ wn oar P:eeno $oMme RE$om $Mosmm $uowm we iPewee 5r1e8 emm oo$em wrmm oes vWvehe M LW em B$ 8i2m0 iwge ores v;heano e$Mms RReos o$WwEs o$uowm mem feFweo cd Rm $oduE u$eame :woma owes Vhveene M$omEM$sEm Oo$ WaE $uoigs OH-SUM- 7 08-DEC-98 w warsonmors z3om 33om u$immm u$inm $uamsee oomse owwm aosz usmm $aimm $ooomm aomuse owuws $oumm $ueaym o$umm 1 iatt-tst band on ested van 81. 48 5 or 18 ev. i 07 000108 NOTOX Project 242933 Soars BS TELOMER ALCOHOL/TELOMER ACRYLATE: PFHS/PFOS `FOAREFGMTEAARNLIE2BSWOEDEYKWSERIEGCHTORVAETRIYOS SUMMARY _-- meaner --_-- GGf owL c GArrc] mwes Gar wGoornw. ieWmhe :Bwow3 m i w3FS &wove iFeo a o h soM RFo m ou me r eiSeo$gcam $oolm oMEm woeRs w ty eeiFee $S sn RE$sm IaRs Ms0m awvers eiemo osRs Mo Rm :E om M$on rolows iFveene MsGo 0ne0m 0e m o$umm s&eo iSeome. oGemn :osemm eoemss esamm oEswes FvvemZ ons oom em ows ON-SUM - g 08-DEC-98 e mrsongars io m 33om ao km ii$cwo oo wms ousme :3amm eimz we ee $ooep ooems sooam o om om oun oom nos "17: Dunne tst Based on goed varance 545. at 58 a 1% teva, 108 000109 TNEOLTOOMXERProAjLeCcOtHOL2/4T2E93L3OMER ACRYLATE/ . 'PFHS/PFOS= OH0-8S-MDEC- -989 AOFRTGEARN4WWEEIEGKHTSSR(EGCROAVME)RSYUMMARY MALES _-- TREATMENT --_--_-- GCVNEOHTIPROOLLLE AGLTUCEOLPHOORZLR ACTRRENYLLOPAWITRE GPA PGHPS.S pGrRoOsUPE Bovw. MSTe.m08v. a85 N 3 3363 a3m 3 3 3"%ar 2335 3 w4u4 3 AN SeTaOn . N 31os7 2.l0o5k 3 02..0039 3 02.1151 3 2o.o0n2 3 02..0007 3 : HEART N= ST.08v. 1.o1l9o6r 3 10.200s7 3 oLlaor 3 10.1 299 3 10.1018538 3 o1.l28s1 3 ver STe.a08nv. N 11.03.777 3 9o.l7s8 3 310.60.30 01.08.505 3 oseee 3 1n5a47 3 Koes STs.eomev. N o2.n44 02..0462 3 3 o2l50s 2o.5z 3 3 o2.2 r 3 02:.2418 3 ores SeTm.t06V. w 30.o0i 00..005009 3 o0.o0o5 3 g0o.n0a8 00..006073 3 3 00..000696 3 sea vSeT.n08v. N 00..064104 3 00..05802 3 00..05611 3 00..70287 3 00..056552 3 00..16326 3 Testes SrT.e0nev. N 2o.i8e6 3 o3.d1a9 3 0a.016 3 3o.1m0 3 3o.0n9 3 03..207 3 "1:Dunnett test based an pooled varfance sig. at 3% or 1% level. 000110 109 NTEOLTGOMXERPrAoLjCeOcHtOL24/2T9E3L3OWER ACRYLATE! IPFHSIFROSeat ON0-8S-W0E--5180 AOMFATLEERRS4 WGEEKAWSEIRGENHCTORVBAETRIYOOSSDUMNYARY -- eme-- ri--e--s--GWop-- Ei L--GTe:---- meurss---- Gore--E-- oames--m-- ars ee Gime oomeeAwe ese oE or. e: W n w 3 w$3o m oFSw o83 m w&3 m w&o vei emo e3 8n0 em $ MeEm :om0 woeme om w5) ereiFeo o0 Wm0 M Sems dmo m om sm mom :oomm w&e eFV weo 3 D 23$ mB M am m$am 3a8e a3$ me owrs eiFnee 0w$ 8s0. em $ e0$ s stse 0w g omo$ m oores yVFeewo c0$ o8 :e28oD $edMw sSamu $ocomw $oooa s&eo ei whe d$chi 8e$ s MamEs Ma$ iam :soum oo$ mm EE 5 ew en iST.0ev. $0.04 em em am o u $0.02 $0.05 ame ose 0.02 $0.08 0%: Dates Based on pasted vanes 1g. at 5or 15 Teen 110 000111 NTEOLTOOVXERProAjLeCcOtHOL2/4T2E9L3O3MER ACRYLATE/ . IPFHS/oFFeOS OH0S8-UDEC--9181 `AOFRTGEARN4WWEEIEGKHTSSR(EGCROAVME)RSYUMMARY FEMALES TReAENT GBCOoiNpcGieL GTAHNCEPLR? GATRPoArTSE GUP4 FiGsOFS EGyRE --_-------- worn. SvNeome. F27a0 mi 223 6 2335 i32s 32it08 an seNSaone. Lo3otn 301.9076 Las ooss 031.%96 o31o8 0sL0oss i rear SrNteaot. oo3 usst o3Qset g3oossm 3oomse sooseos 3ooosm ver wNSeone. 7i30n1 c0so7r e8s s 7s1.350 so3 nx 703.5409 i Kors SjWTeOe. 03160 03e0s8 31o3t4 3Loess o316z2 sLoeis rewis STwN0eenv. 0o3.o0r6 o0a o0ls 0o3 o0m2 oOs oo 0o3 0os oa3 oom sue wNTome. oo tuss oo3 uisw 3ocuasi 3oolsduu 0o3 aomm oo3 omk owetes SvWTe.0mev. 30caoms oo3 oam oo3 udss oo3 osk oo3 udes oo3 aon "1: Dunnott-test based on pooled variance 1g. at 5 or 1% Tava). 111 000112 NTEOLTOOMXERProAjLeCcCtHOL2/4T2E9L33OMER AGRYLATE/ . PFHSL/PoFOeS OW0-8S-UDMEC--9182 `AORGFAN4T/BWOEEDEYKRSWERIGEHCTORVAETRIYOS SUMMARY _FE--MALES e_A--nen GVCOiMRaLI: GfMiCPbRe1Lr - WoAeeGssE woes GwePs gfasre wGoaw. eVSome. 33a 3mi 3=6 ni s Pyi 32i0 m[9an eSitme oo ms oo3 ms oo8 am oo ml oa3 mm 3oesn . r eisow. a3oimm oS3 samn oo3 own e3aonm. 3oomaen 3o0m : wR egi omw. 3idme se mm o3shm 3am 3simm a3: e8 atoves esW ao. ao w e0 m 3ooeh 3oonm oe nm o03 m%e oorrons viseon . 0o sm od3 aoem oo oem oo emm eo$ aomm o3ooum me esomm. o3eeams d3ooaw o:oews o8oemse o3ouar o3omae i oneies vsVeom. 3adoss 908 00ms oo$ oe oo3 oomn oo oemm oo3i om 1 Dunats- ast based on pooled vartance af. at 3% or 1% Tovn 12 000113 TNEOLTOOMXERProAjLeCcOtHOL2/4T29E3L8OMER ACRYLATE/ AHINSITMOARLISCOALFD10A-T1A2WHEAEEKMSATOOFLAOGGEY * MALES AND FEMALES PFHSI-PFOS PARNETER SEX x WM STO. MN WX samnc ]7 "50 crsm oomx osse 715m man flF "5 o2.s8 0035 oass 1100.48 wrin ; "50 oosues ocoos ooms 0o4dms wnv u7 "5 wsmss 11s B5a a6.76 wwi aru "Py L1a oeeoss risms ruame mwocn F "0 wBr 71os nms1 %m3s IPLATELETS Wv "50 nuiye E6d0 11s s5on ; "50 w2r2 o0s7 wmea nulg avnac Fu "Pl 5w.2e 2267 5o3r 1w7s sioron Fu "0 oooar ooeos ooos o02mm een Fu 5"0 o00s6 o0w0s7 00 00.002 meeon o7u "5 0o o0 o0 . PiR re) ]F "5 oosws oowo oowrss 0ossm wroey o7n "50 ooosm oooomm 00 o0.l0o8r8 PBrS 7u @" wBs21os nie o5w7s ewrer 3"% Bs35181s wnse wwha HIS2-2S-UAMPR--991 caanttainueaurse ffrnotnraSvpernaaguse nafvulseiyon.conDtursa]taratthee WThiiacihterdacaavtavieTdabtIhTeItvyehoifclaeta(fnnogecnoenrfadlen0c.e9.% fNnAtCeIr)vavlisawere caleatated. 113 000114 NTEOLTOOVXERProAjLeCcOtHOL2/42T9E8L3OMER ACRYLATE] HAINSITMOARLISCOALFD13A-T1A8 WHEAEEKMSATOOFLAOGGEY! MALES AND FEMALES PFHSIPFOS HI2S2--SAWPR-- 992 pone SE 0 aw sTooe. WN ow nmoc uF % 2a4 eomn s3m% e7g6 "man fuF a p9.o3 1oss 756 5un5 wirn u' a 0ow9e 0o0o0m 0oasn oouuns : weny 7 0 B5a 2219 #s3s sae . i wo on Fu %a i1sm ooeosm 1os LLaam : mwocn foFw r)y an1e ooss mm24 mwee Panues 07 3 wnso wums o0s 1153155 on uF a@ wwse 1o8s 2w7e wisz wanc ; %2 a2 2ss "61 i 9 seeson Fu %Py oouas ooim oooo oosms 0een flF EFa) o0w0s9 oowse 0 0o.o03 } rwenowOF a oo oo 0o 0o . ie ]F oomse ooiis 004ss oosas wreyowF aF ooeom oaoms 0 0o.1o05 owre fl7 a wuez 11 a wnss mwae eprdr u7 wwes 211s wnse mwas +cCoaanntttieantuaoaruses.frraanvaSnoraaiguse IDnafwulseiyon.conOtursoltoratthse wThiincihterdocaevfavTeTdaptIhTeicvyehoifclGeat(einmogecnoenrfato0n.c9e% nNkeecr)vatvisawere 114 000115 NTEOLTOOMXERProAjLeCcOtHOL2/4T2E9L3O3MER ACRYLATE PFHSIPFOS HAINSITMOARLISCOALFD10A-T1A2 WCELEIKNSICAOLFBAIGOEC.HEMISTR*Y MALES AND FEMALES WET SX N A STO. MM wx aatmien W Foss 0o6s oomm ooums oloss AastktiicoT M LEs] 22m6 oosm 11ss aasa soulr. N Fose 25 1i 12 54 ; coolier. N ross 129058 o04s 1toms aalmm I aTmIoGL} NLI om ooea oowm o0%u oaeu mcolome WPo oest a .` =a ES mcoulcla LMoIs]t 260 oLeo saws a7u4s mwearlt PPE os 6a11 2116 3is 812s8 RaOENT. K Foss "a412s4a #237 mmss MIaan FWome w5s 21s u2s4 muee aanww M Poss uWss a4ss m=1a aa7s i NT emo W [Im] 01 5 o0.i1 0076 11 3 oawte i NPooms zosw wtws a2ssm m7s8 smooolnl] WFooms wwaa 16 mwss uiess Pmolols H Foms a8m 00ds av5m ssym aooulmmE M Poss 10ot0 3s 55 1i0t6o HI2S2--SAWR--993 ccDoaanltteitanautaoerudas.ffraotaraSvpernaoguuse fDnafnulseiyonc.onDturea]toratthse wThiiacfhterdecaovfavieldabtihleitvyehoifclGeat(einnegecnoenrfailden0c.e9.% nNtaaCrl)valvisawars 1158 000116 NTEOLTOOMXERPrAoLjCecOtHOL2/4T2E93L3ONER ACRYLATE PFHS/PFOS HAINSITMOARLISCOAFL D10A-T1A2 WCELIENKISCAOLFBAIGOECHEMISTR*Y MALES AND FEMALES NER SX NA STOEL Mn. ma eowouliln Fwoss mmool,l SPH. MF5o1s 2260 o0w0 2aua 228a 22 bosm 220 aamm HI2S2--SAWPMR-- 994 DCoanttianuaoruas fnrtornavSepnraogause iDnafvulseiyon.conDtureo]toratthse hTiicathtardecaevfsvteldubtfhieievyehoifclGeuts(innogecnoenrfadlan0c.9e% INnitCelr)vavlisavere 116 000117 TNEOLTOOMXERProAjLeCcOtHOL2/42T9E3L3ONER ACRYLATE! IPFHS/PFOS HI2S2--ASPR-- 955 AHISNTOIRIMOCAAFL1LD3A-ST18A WCLEIENKISCAOLFBAIGOECHEMISTR'Y m _MAL--ES AND FEMALES. e P--_v--E se N STE. Mn = sawtet FWoown oosm oalms oome aiim waatvier FWooan d2a6 o0em 1lse 3a%w Jamiurr w Powm 52 1i 21 s4 ; pcnotst PWoma n1e: ooess tosm a2m : mioal, a [I o0as 0olms oomm i1aam ii smGooilm1oe W Poam 7a 54 5z 2" maotsie L4 E m s 2 om1m saeme 1wae wwaelr) w Powa 5573 U[PsR sr 5I%n aMnENT. [W I w mwse oasss xde a ann a w Poam =mis8 n2s wsae aaitmin w Poam wws2 4A2h oMwe fe nemo [W I w o0s7 oozx 0a54 aaa Jnaee F"ooan F3ECT S Le vas gs soootnt FWooan wwoo 2a7 mwsa iuees milos [I a ws a o0m% Tamm 3shm mcauiml: [w I w 1000s 33 5i6 i10Y7 CcaoDlnacttuiatnauacoreueds.firnotnraSvpernaoguuse fDuaswlieoyn.conDtursoltoratthse wThiincihterdacavoevTeTdabtih1eitvyehoifclGeat(efnnegecnoenrfaoln0c.e9:% iCnc1o)ruavlisavere 17 000118 TNEOLTOOMXERPrAoLjCeOctHOL2/4T2E9L3O3MER ACRYLATE PFHS/PFOS AHNISITMOARLISCAOLF D13A-T1A8WCLEIENKICSALOFBIAOGCEHEMISTRY ' MALES AND FEMALES e ETE se N e WASTE.e Mw eet acmo w [M I a 22s oonr 2a%m 2asm mooRll.] PSHMFoom42 2216 oomu 2iems a1ms HI2S2--SAWR--99 ccoaDnlatetitanaucaserudes.firnotnraSvpernaoguuse fDuawslieoyn.conDutsrotoratthse wHhailchterdecaeviavieldaptihTeitvyehoifclGeat(eInnegosnoonrtalon0c.e9% INkaeCrl)vavlisavers 11s 000119 TELOMER ALCOHOLITELOMER ACRYLATE/ IPFHSIPFOS. NOTOX 242983 TABLES - INDIVIDUAL DATA 49% 000120 NOTOX Project 242933 TELOMERALCOHOL/TELOMER ACRYLATE PFHS/LPFOLS MORT2-4I-NFDEB-- 991 MWOARLTEASLITYDATA : GROUP 1 (VEHICLE CONTROL) wosNomSe ov mReeen F31 Rooixoov]ire 1 oGGioiaevvvaee 5[5 rGieoh]vr H3o oiiebohevraass f Br R] R GEoGsEo.lC0oTccrT-ao9an0 rGGeelaoiciotcoonTne GGOGEGGEEETTS3a8 GGEGEIELOIGCESTTCgT3sa0 0GEGEHToe oGca2aNoNovvv-..s33n88 GGgaanNaoovva--a c0Ca33t00e93r88 00Sa3h0oovvy.-aa9nn8 SGahNoovr-e3s8 ALES `GROUP 2(TELOMERALCOHOL) wowsEoeGSee ove Rreee ne 7iBoosvreanv Bn oNeve GGEo6go.-0ccEcTTr5as8ns oo0x2xh0oa1v-o.9a3r88 GEGETne 0 Nov.33 f I5 roGiioo]vvas Hoe EGGEEEGIECCTTTIa3os0n 00G3a3.hnNooovvv--naaesn Eo tora T niieinvenea GG0G6GCE0ITE30sTa 000a33NMoav3m.0 BF 5 oRrGi] ec GEGGIEEOICI0TSC33TT00 co03y-ahoovnr-sase8 eemiiomeeeeeremereememt . : 120 000121 TNEOLTGOHXERPrAoLjCeOcHtOL24T2E9L3O3UER ACRYLATE! PFHSIF-Fo- S : MMOaRTeAsLITY DATA `GROUP 3 (TELOMER ACRYLATE) wonsEomHe oe nAoAmen F F8Pa RSa e]v B3u$otrshe eenrr $ 4 8 aee a rnn aoaEEn EweagaacsRrm98 SSaarooorrrra SoSSErEiTnrR oeSSehrrronanr ppEErrEnaassHSiaaeerrddnn SSiinn i Sern !; Saheosu4p noseSmEe oe Anemen 4F8Pia Sons oer %Fgai wtaehbennn B243 iiteeern a& annk sEwasoxcnRrTan SsStoeorrrraaae ESCSealiEenrna HsSSioeeerrrrnsnn XrSaTsEt morn eBirear sErn SSoerna MORT24--I7NED8 -5)2 fiat 000122 NTEOLTOOVXERPrAoLjCeOcHtOL2/4T2E9L3O3MER ACRYLATE! PFHS/PfFOeS MORT2-4-IFNEDBL. 939 MMOARLTEASLITY DATA GRO5(UPFHPS) AOLsNoECeROuPSeY omer `Fmdeant TO 6&& ooowsvaavrsss @7 oooiislliaaovvvsssses 7773 ooihhalddoaovvvsssees 777 osleednvesesen ; 7 oGanoecaas dQQ8Ee..o00cCCTTT-..999888 000666:1.000CCCTTT..939888 60661.:000CCcTTTi33s880 G0G6E6.0O0CCCTTT339888 GG6E.G0ECTT.5388 000222--.NNMooVvv---599888 0G2G3.3-M.N0NoVov-v-595888 000333---NNNooovvv---959888 000333--NNhooovvv---09888 0033.MMovv-5508 | `MAGLERS6O(PUFOPS) -- SR aL sNaE-- CRnOPSeY -- omer -- FTERADE-- NT To ---------- 8a ooossailoorvvsssss 00066.6.000CC-TT933888 000222--.NNNooVvv---595808 o85a occaahnnooovvsosens 06G6.E.00OCCCTTT.553888 000333-,NN0oo0vv1--.035888 8a oosiiooavrvsasss 60G660:.C00CCTTT.5.35888 0G033M3-NYNNo-v-9-99888 ; 5s5i0 o1isa8delocovsvsses 00666:0:00CCCTTT533888 000333-.NNNvoovv---90o088 55 ooercc.ass8 0068:0OCCTT3588 0033-MNoovv-0.8 122 000123 TNEOLTOOVXERProAjLeCcOtHOL2/42T9E3L3OVER ACRYLATE/ PFHSI/LoPFOS MFOERMTAALLEISTY DATA GROUP 1 (VEHICLE CONTROL) aLsaNEECoROuPeSYd ODER `PTRRMEATENT TO 95579 ooassstoaavvvssssee 1010100 oooesgloaavvvsssses 11003 coeglNoovv-ssse 111000567 222000H4K00ovvv-sss8e8 `i 10n0m9 00o4cE0oCEeCc99s00e 000888-..000cCCTTT-..999888 000888...000CCCTTT...999888 0088.0.C0T.C95T88 000808...000CC7Tr...955888 0080..00CCTT.5588 08.0CT.58 000444-.-HHHoOOvVV---999888 000A55...H44O00VVV---999888 0053..MM00VV--9588 000383.--MNMaovvv---559888 0055--NAoVv--9588 03-HV-58 GFREMOAULPE2S(TELOMER ALCOHOL) AOLsNoECRnOPSeY oTER TFRREATENT TO 113 oosstaovvo-s9e8 111s67 oodeslosovv.sssee 112890 dcoeeelhoavvvsssee m2123 20 K0okok vvsee 1112265 40e4dDesEcC.oeon8 0OB8..00CCTT.-5988 08.0CT.58 0044--HNoovv--9988 04-Nov-98 , 0088-.O0CCTT-9988 0043.-NlOaVv--9988 0o0s08...000cC1rT...995888 000s35-.aNAovVv---s59a68 0o0888...000CCCrrT.'595888 00G3s3..-HhHoaovvv-.-9s3888 O088-:0GCCTT.-5588 0055--HHoVv--9988 08.0CT.58 05.Ho0v-98 MORT-IND - 4 24-FEB-95 123 000124 TNEOLTOOMXERprAoLeCcOtHOL2/42T9E3L3OVER ACRYLATE! /PFHSIPLo FOS MFOERMTAALLEISTYDATA `GROUP 3(TELOMER ACRYLATE) wowsEmuR ov mRoene 1BfR roasao]rm olSesivv]a 5Bforedeeavnrs dGdn eovbs ONE Gorse ofGnroaOcercTscnl suse oanovae GGGoir0sre eoosstyosvoae GSSEoooctccss oo03rraaaovoo-yvaaan GGGEIioooccTttssee oo03 sMroov-aaann oGoTr oovsae FGERMOAULE4PS UTsacouen ER Tene -- us eoaveonrr is Seva GfanroOcarT9c9 gooaueotnve-arsyss fra mci i 5Bace oev Bo oeov ppparrcaahicaaa GOT bryan BBoRe aivoas BR TffrrIaacc id Siena Goranoslo ss MREEER GGoEcTe oo3aroyaan MORT2-4I-NFDeB.-095 000125 124 NTEOLTOOMXERPrAoLjCeOctHOL2/4T2E9L3O3MER ACRYLATE/ 'PFHS/-PFOS MFOERMTAALLEISTYDATA GRO5(UPFHPS) ADAsNoECEROuPSeY omER TFRREMATENT TO 11661 oesnsovo-sse 11664 o0ssNoOvY-o%e8 116656 oGel-Noovv-eos8 116678 coseNdoovr-sosn 11609 22004k000v9s8s 77 o2d0Ec0esn 475 oo4aoeEccessn 0088.:00cCTT-9988 0088-.00CCTT'9988 0088..00CCTT-.9988 0088.-00CCTT.'5988 080-8:00CCTT-9988 0088-.00CCTT-9988 0088.:00CCTT-.3988 0Ga4--HtaoVv--9988 G0d4--tooVv--5988 0035-.4HOVV.-9988 0055.-MH00VV--5988 0055--H10VV--5588 0055--101VV--5988 0058..1N00VV--3988 i FGEMRALO6ES(UPFOPS) DOL saRHEECDRuPLSEYD OTER TFRROMEAD TO 1mm8 oosdnoovrsse 9is 81 ooastioovvsess 06Nov-%8 882 ooggMMoovvss i18s5 16 o2e0n0o0v0.9ss8 2010098 w 11980 o0cr4aepcee .cos8e 11 caecse 00B8--00CCTT--9988 00B8-.00CCTT..9988 000888::-00CCCTTT-'955888 0088..00CCTT..5588 0088.:G0CCTT-5988 080:8.00CCTT.9988 08.0CT-98 0044--MH0OVV--5988 0o44-NNa0vV--9388 00055s---Ntt0ooVvv---999888 00ss-.t1oovv..9980 0055-.H1o0vV--9988 0055-.N1O0VV--5988 05.40V-58 MORT2-4I-NFDEB-. 996 125 000126 NoT0x project 242933 McArLoEvScas sens GROUP 1 (VEHICLE CONTROL) sToima<)3 statoa.ce) TahEr! A bsA s dA asA s AA ma 2 Cirirriiriiiiriiriiiiiiiiiiss SoTraR sE (ofa eIi TIL GIA ofTaEToR hy G1 i AL cL GILLe. ee ; fAGrEoeEedt(aar7 CRier Go AGL oor, Ge A. ooo SERrace Py : S(=T G1 i IL, ooo [E =Nao=ten OF re @ PLLrLLiLaLIaEaLIaLLaIiINiiiiGiLiiiLiiLiLiii Gt crrrenennene sss AEs SSEa ordewn 3m}acs C3 oo LP LLLLLLL L hhbdddddddddL ididi ibiidid, hao Piaaaaaiiiiiiiiiiiiiiiiiiiin i via em 0roam cLpoN,sta sor m4msGr SiG:oHaig2he0s0t%gFroadtsis ma) A: 0.00 3: 000 126 000127 NOTOX Project :242933 GicRuenOvUsiPca1n, (sVtEamvIsc,LEpCAOTNLTYROL) azaroo ces fr-- wana3 SReooebTamm of oe [p-- amo 15 woeose a 0rumencue. sumswore mmsce BRE SYM-IND - or ghtaly r aden 127 000128 Kotor pro3jec 242523 seHxoh= MCALLIENSICAL SIGNS GROUP 2 (TELOMER ALCOHOL) stan oe.couce) momen TmHEe! ALAaAsse c AAAs AAAAAs AASS Te 5 SI rn re oe II ERE EERE EASR SE SE wR 7recs ote ten saaaaiiiiiiniiiin ini STR [rec [rc -- rriiiaiiiiiiniiniiiiiiiiin SFRae = siiiiiiiiiaiiiiniiniiiiiiiii SRR ec REEdon srririiiiiaiiiiiiiiiniiiiii SE FR 7 once rmicArzzaarterim) piriniainiiiininiiiiiin SO rR race =) rnb . SE wn 7Face Toa IRIE thre naam) EG, Tohoree LI SII aA arma SaESaSnSOOOONONY FPirna-- Titer-- Editmacs 0) a0 0.00 3: 400 128 000129 NOTOX FrPreoyject 302933 Sv2e3i5n78-53a MCALILNEISCAL SIGNS . GROUP 2 (TELOMER ALCOHOL) szav oa.cane) macan TmRsE: AL AAA AAAE AAAAAAAABABAAABAGNRAEAD SER Fase friiaaaaiiaiaiiaiiiiiiiiiiilg camrc 0 FURTHERCLINICALSKS WOTEDTHTHIS GROUP. _-- T:inHaigahfetsetrgCrraedaetsmeat (LM Ai 0.00 B: 4.00 129 0130 00! LcuEnvSican stavs, aT GROUP 2 (TELOMER ALCOHOL) Py -- fr woos 25 Sor RESho cern eno 26 Sone peck [rg 3 SnTTRm mAeaebDeo rEam smo 39 -- 8a7)srace o tm A mm 0renceosz wre 7mscote Higathly egrantes A ------ 130 000131 woTox project 242933 suHr-uRo S- 6 McAuLmEvSIcan Stans GROUP 3 (TELOMER ACRYLATE) stax pou.cuce) mena Bsre a basses eet s dansea basores -- So rece fteo BToERm an Cr frtiiiifiieiiiiiiriiiiiiiis DIN 6 NPI oooL Gr MULL eee eseenes j ooa ytrem1am(ro)fece & hpriadbaihiiiiihiLiUbiLihLiihidiiliiiiiiii Jeroeaomn en HL oes we aTByoaarn / Rasece o L PrIriLiL iiIinAiNiLiRiiA iiiiL iii a . OFORHERLDA SIGSBOTEDTHTHESGRE FG1inHaig2hietsetrgEroadaeisane wa) A 0.00 3: 000 131 000132 Notox project 242933 MCGALRLIOENUSIPC3AL (STIEGLNOSM,ERDAACIRLYYLATE) sTmEoAo cance) ves: sT ecovmy s, p-- E akhd e ern 0 rE CLD Stas or I ms GE spor on _-- Highest catty grades 132 000133 worox progect 242933 soHemS- o . cMLAoLvEIScar sTans GROUP 4 star pox.cao meen TBEa bN essdA AaAAsAAsASi AR AA Na AA Ad RSAD ST re TR en Soi[n TweaRbfardaE ce p Sm rn pases dTisot To wan owis a em HII GDAHLLAI EILIA PL . D=axf(3)e ET= TaFsR) Ree 0FonER CLOGSTC Gh @ LPILLLLLLLIT LL TEDTiTs Ree aa AI LN dddLLL PFinTBi--te_r--Eelam 0) ni 0.00 8: 400 133 000134 NOTOX Project 202933 MCALLIENSICAL SIGNS, DAILY GROUP 4 saxtoioxn.cece) EES: T soemDS. ama 61 S"aN(n5oierwei,ern()0)ed even III, aDdEzaEnnsma om n(3)em vevam oS r imma IM-mum nun, B(aa5r2nkReGarmmE 1) ve mam OMe LR rma, 2 frTeoaeew(3a)te Grhe: Mrscsontsrnssmsessssasssnns TOFURTHERCLD SIGSYOTEDDiTISGRO so3e5m50-8g -_-- : Nidgallyhgratdes 134 000135 woTox project 242933 sptr ro 30 McAuLmEvSicar Stans GROUP 5 (PFHS) sz oo.qucn) meme TBEE A biviseA rtAaAoAA eiN AcNeAA BARAGRD SToE i rheRdrea ET oo Ee we oon e LE LLLhbl hhbILLi LILLL PRR PIII DLL Son wm wee ac isCaovicecn. oeAke 0roncmon,sta orm nnn aswa H5o;Hwo2t2e5s0:5gEroatdheesnt (0) hi 0.00 31 40 135 000136 HOTOX Protect 242933 MCALLIENSICAL SIGNS, DAILY GROUP 5 (PFHS) siaatoian.crac) WEES d secoe n; Bb S. ama 76 oHAsSEDroSTRE (1) Or Brsssrorasione amas79 E RfED=STAn DE (3) Bt sessediluatsomsronsistaion R(iC2onsTvhioon,mRsect0a)n Or evi aI, : TTfoae(3)m Bt Tvrensrrensssnnssnnernnnns MoFURTIERCLDUION.SIGNS FOTHD ITIS GRC sTnarnas -_-- Highest dailygrades 136 000137 worox project 242933 cMAuLvEIScaL STaNS GROUP 6 (PFOS) sanome.cuoe) po-- E B=el)inr oF rTEh mone TBEe bS iAsAeNrAtAA iAiAeSssrA aiaeatN aAaBnAeBAGdAD rrirrriiiiriiiiiiiiiiiiiies Bt PRRDLI ttINI IRI LI ALI N I SaTors 6 sec PR L ARR E RRER EE LRARR II ET = PRI SEER meGR| Giiiiiiiiiiiiiiiiiiiiiiiiiiii ws : 0roRriencLpen.sx Bor 21 IsGece Si5:oHnigShEe0s0t%gTraidteshe a) he 0.00 3: 000 137 000138 NoTox Project 242933 MCALLIENSICAL SIGNS, DAILY GROUP 6 (PFOS) soaonoow).cave) WES: `TRreocoonverBy enne nbinenniSe mas 95 E To e s YOf erireraeiAIL HO FURTHER CLINICAL STS NOTED TH THIS GROUP stEeme13 -- ee ---- eee r ------ Gi Highestdallygrades 138 000139 NOT=OX Proj3ect 242933 - SYM-IND - 14 25-FEB-99 cFuEmMvATLcEaSr, sTaNS GROUP 1 (VEHICLE CONTROL) meer sx oneucer PwEe AA LsessdanA ssdasosA NsAtAsIEaABnABeRD RaTaiasnntaee0 femSone,e3n8 en Se LPLLLLLILLLLLIL UIhhIhIIbIbbII o SDLITEEL ALISILEIEL RERLEhELhEL hEEbEL bEbhL EbEbEhLEbiEdL!HH. TIIIIIIIIIEItIiItIiIL E Ba T Caan ra a HEH EEAEEA E EHH L HE kh nnnnsnnnannnn : ra Donnas EAT o ra:Ame oram) G1 AASSSSSELoo. ooo SSE G1 SSSAooo SEMIN ooALL E Torr an of ster) poe o DLUiLLEhibibiibabibiibib ibibibhibbbibbbidbibid SE 7Rae Neem eh BHceE=naR a DIT J 1 errr Geer AL SiPoon-- E00 olen a) A 0.00 Bi 400 139 0140 Notox project 242033 so2n3-ores1-555 CFELMIANLIECSAL SIGNS GROUP 1 (VEHICLE CONTROL) . mono sta oo.caso) BTOER ALANA A AS RAS ANEAAAEANeAAT AAs ABAD O fEsoo EtRorterm T [OS e A CITE aes tan 50FURTHER CLOICALSIS YOTED THTIESGROUP FinHaigShtesotrgraatdaeasnt (HM) A 0.00 Bt 4.00 140 000141 NOTOX Project 242933 FCELMIANLIECSAL SIGNS, DAILY GROUP 1 (VEHICLE CONTROL) stteanripaax.crave) [rg svioses: coS vey RE amas 105 STSaoanasrd0T) ra mas 106 Gr oa. S Nhoabcza a (3m) aewnOh rine lL | mas 109 E orbicr niaRe(3c) Ot ere Minn ANmboGertnaow3GO))Len) Go HNL es 0 MIMoI oo . a odra : amas 11 : sN[orm eser nee rennin AMATI HAoloowwmrzatm)3)) ssssmsonssniiisnemsse Gf eo Afnlao=graa 3) Gere MIL o mun... Artlrdpiieecrerh re0))e o mmm... TO FORTIER CLDIIONL STS YTD TH IS GREE s3o55m38-5156 : Highest cally grades Tl 000142 ox protect 24332 sms cFGRuOpeDmPcsa3n staus (TELOMER ALCOHOL) sx fo cons pon a : . Se ESHA sa 25 rn JIS IIL EI PILI INIIAL ges 117 Ch SKIN /FUR /PLOGGE Fates t ists as at atti atny PERI IEIIEEERATAERAIAIRRAERT SO FoR PUGGE sa 122 ne SKIN /FUR /PLIOGE rng Leal, : or A Priiraitaiiiiiiaeraeiiiiiiiii rrr Brtiriiiiiiiiiiiiiiiiiiiiiiii : mn SKIN / FUR / PLMOGE oe mo, amo 123 : wore SKIN / FUR /PLGGE Piiiiatiiiairiiriiiiiiiiiieies errs Brraiiiiiiiiiiaiiiiiiiiiiiiiii SKIrNs7:Fm J PeGE Priiiiiiiiiiiiiiiiiiiiiiiii: [Fr-- o ------ So HLigEa EgraEs wy Aot0 mao 142 000143 NOTOX Project 242033 FCELMIANLIECSAL SIGNS, DAILY GROUP 2 (TELOMER ALCOHOL) se1catoiooxn.)cece) EES: sed con Bebe. mas 121 Senre Ofros Gr ora, MA(GoGErEDo.ermG0)1) 6 uz. or amma. = Ren amos 122 E Nlaompeetn e(m3)) 6 mz, ulmommvserR0e)3o)n G ... 12mm, O evetzni, s[GaEem=ms= a(1rn Gt ervetniz, 0 FORTIER CLIVICAL SIGHS WOTED I TIS GROCR PToron]s) G-- : High-- este dal-- ly grt a-- des ---------------------- 143 000144 Notox project 242833 sv3en0- a19 cFEuMmAvLrEcSar Stas GROUP 3 (TELOMER ACRYLATE) sxc ax.cce) mena sBEm A bsA A sd A ieS ts RAINS Ee ERE REARS AA 15oasms 0) ervvemessseree eessensssssaAnHnL ! at . Sm Tn ra LLIN Tecra teem) [o= o5ycneonm--s_ =X Barnstead re rrr AL es AEs osToiR:msome (1) Ge Rn iiriL EgIrIR iiiiE ciiiiLaeLie,d 1 Sn von 7re T= DIINO Sov Jrac en) RS PTI SSa Hoatwrsn 7(rofises a dR rdrA daLhUR aLERlAEEiRiE EadadR ddda1l Fosmon iy ny Te Keoemn PILI $ Cpppmmmnnst Rann P Siok 0-- 0% E--ne wa) ne 000 mi 00 144 000145 NofoTreoxX Projprodect 242933 - sv3e5 nn -- 020 CLINICAL SIGNS FGERMOAULPES3 (TELOMER ACRYLATE) sa oax.caace) manan TBOER AAA R0E5A8SARTA AaABAa LAN S EAREABAEAS mas139 Prriririiiiiiisiiiiiiririees SaRNror7DeFrOiRaro7(3s)PURG(E1) A AI A A Lh Ot erreen TL = amas 161 Srrrrrrirrrrirririiiiciciris S/nmawce Dinninnii ad amos 142 Srrrrrirrriritsitiriisiciris ET PRIN 0 } nas163 Prrreririirieririiiiririris SONroreeTEi)Ra (r3)oe & hdi h hr dhdii sdi ih dddidi ddadrr dbadbeibi ehbeiedddh bdadddh 1o o2wm00o0r rsmarc6))) Bt werousermsesmatsmmasspinors oe URI FoFURTHERCLOT STSFOTEDIiTHISGRU? lS:oHaigGheetsetrgFrraeadtemsent (LMU A: 0.00 3: 4.00 145 HOTOX Project 242033 FCELMIANLIECSAL SIGNS, DAILY GROUP 3 (TELOMER ACRYLATE) Eocat0i0oxn.cruoe) 08: s2eco is sbisrarsbonsini amas18 SPafroDmTorn)oPse0)a(1) amosS13E9eresocnes SNaoreatmrioarn(o3s)Fnae d1) haan amas 141 o mmm, oie o mm, smn, 1 SE5 OD TSTRArG e(3) cs Ot sesvrressonstoasoistn ma 1a . SoHE TRai7rsads orsonrssmtspprrmmerinnitl BoFURIE CuDwoNL STSNoTeDTH xsGrae stuT-atunp s-2y1 -- eee -- Ete emeeeneeni : Highest dallygrades 146 000147 wotox project 242333 4 CFLEIMNALIECSAL SIGNS GROUP 4 ( saroax.cue) mos 167 ERaertenOFe son - 2 25-FEB-33 mone S2ar nsaasielbseTass teased ireiriiiiiriiiiiiriiicoos PRRT RARRRRR ATILI I HRL I iL SSrw eaof ec 2EEeN mEane 0 0: Bd I L LA 6 rev III... S TToetw en opFecs EULAPR AS AE RRL ASL ARI RBI AIL IAI AR"I 2I2N) adWT iReCHETDG pnosTTUaREls(1) Ernr Re SoA= tsnn iion )(ofa Srvara tan @ LLLLLLLLLLLLLL bbdidhdddihisdy covers UNI DIDIDDIDIILIILIIIN a DLLLLLELLDLNLLILLILIL IIIINIEIIIIILdIh reer EEE errr ee AL SoenrnTnn JorFece =) mam emT i ReE SmhasE am) o PLLELILILTLILILILIIIbShbdL bibibdbddy ddibhidhdd 0rome cup:sxe vom imas ae SP ioa22-- 008E-- liane wa) A000 30 0 147 000148 NoTox Profect 2:42033 FCELMIANLIECSAL SIGNS, DAILY GROUP 4 ( 1) sTxee ipanx.caave) ES: Tsreovcreodenns. deeeenbennniSe amo 159 E Saoxts)Y 3) E Bt conssonscomm)simmnsrrnonide R#t2EeDsSmohaBmmmeE 0) 0) 8 polpratsndrrmsersenironn 6 renters Miers sTArTeeEnRciYo,aRDBIr/EeSDaGe:HHsROmaEuEioFxoyRwRUIBGY )(3) EE ran Gi -.ooveeersieniaresennnens HOFURTHERCLOVICALSIGS OTEDIi ISGRO sv5eann-5253 Gt Highestdatlygrades 148 000149 Norox prag5ace 242933 cFrEoMvArLcEaSr, sTaNs `GROUP 5 (PFHS) saanom. ace) su$%me.-2393 momar 2S8a h siasi dees tease SToosTrs GFee STE o =) 0) Fos PRD EHARRb SESRRi RARSi SSARRi SSSREEAN 6: 1t1e11r1Be1rS2r2U2Er21e12e111es1s11v1s01s1 e1s1ss1 1ss1ms21 ss2s2sA s2ss2s. i2se0ss1 PrRnnnnI Smotte7reRr 7(ofooo SaottoerrRh r(oFecs Snre ws o D LLLLR LELGGLLLLT L L LL o PLLRLLMLLLLLLLL LLhhhdbbbd LLL DIEIIIIIIIIIIILIINIIEIIIINN Ames 173 SoR[toteve=n orr e Tasman ER Ha BErrrsrasresriiaitaiataans @ LELLI LLLNLLE LL hbddibibidi rdadahiLi LL G1 eed ATH AMI ns SSaSeaitrrseRa 7opf ecs == SootsrEia fio a ties HEREBen 10 urn como.sxe o PLRLILNLILILILILILI LhdhbabEbbILLEL LLL Gn MII @ B2 IIER IIIII LIII IA L RIA R IL I ) LIES, orm mmasGee : GF:Htig2hes0tgrEadese po) 2000 m0 Tee 000150 [I CFLEOvEICSAL STQNS, DATLY `GROUP 5 (PFHS) oixkgoo er wast sEcoben, -- S BEsR T ama. 74 Err GE B hmn m ar an i amo. 175 i: SKE RIE tNao/xFrw URR /hPeUMOGE oett at J [SE ---- -- pri or apere dtiy geen 150 000151 worox Progect 242933 sopupraa cFEuMmAvLiEcSar srans GROUP 6 (PFOS) sanom. ace) meen SEeE N beeA At AAAs ANe A AsASAeAAAtIAD . i pov oonnTeas(1) Toe TT or rensrTosaa1) st(oorEna t6Eam STot=vs n0)7re Sm ron wes ws SottiT ahr,a piece Bd A RE Ls GILLIE LLL Lg Sa Gu eereeneneALeINe,eaIeIeRe.s Pp -- on I LILLI IE LI LL PERI o E LILLE E hhdRdbEddEdR iR didRdbddE DLL 5ron wees To hina 5 Ta (=X Sm ree can DIILIIIDELIIIIIIII Sooa vto Grf ec PPRRIAILBIDRIIAIIRN E{RRi RRM RIIHMLE 0FUERCLEC ST NOTED 4 a GR SiPe S0-- 50 E--lianciev) A: 0.00 3: 000 151 000152 NOTOX Prefect 242033 FCELMIANLIECSAL SIGNS, DALY GROUP 6 (FOS) sExreipeox.cae) EES secovedsye Bede5. ma 165 So[sen 2SwwBwn3e7 aE amo 106 Br seitherseersess SOUitadS)FoRnPIum(3a) s or amu. no 167 E eTnadT) Ar B (01 6 nua... 12 nara 0 6 aun... 1Rp2EDSsrTmAyRnT (2) (3) : rorssonlibies Of evita, mc amas 150 SMaoaarearm)a (0)mee [I BO FUKNER LBNL SIGS NOTED I TIS ROU sonu-3- 72 Highestdallygrades 152 000153 NOTOX Project 242923 MBAOLDEYSWEIGHTS (GRAM) B1w-7mwan -a3y meaner ajavms=s. i1 25 :3 F2Y is3 Fr)3 FiY 2 5< rer---------------------------------------------- + waczE cannon) 331 3 m m mo o oa a m eH maosa cdadwm mo ae mo20d om aw3mmm om damms0 om dM omm R3a9m ue om 333 3 m mfos ae3B8s fm Gl dBaeee da aammseo awe aaass om a33msa d3 3s 6dd am iBS mo aE 05 m mo eBe adwe Bmse moem asms odme awmm B0e oIn i m w wa om w m iodo maaooemm aamm omwwms Ew a=wms onwmawm onm6ms om me aaommm i# T moz m aozsZ m7 o 7mmom o3 w %ow a@ wow 2 (rma oxen) iis1 2% 2ame daamsa as a2am ms om 3admoo Fo awoma as mowm0w am 3m33me m sEma m8asm om im iB2 i dm1ee me aaaac ae a@oamen de adameo 3a 0goamm a3wmwb 30 a3amsm amo 8B3e ws a8e 3i amoso me Wawm H ds Wae aEW B am dm 03m 7 wom ms a 2% aw as am om . 332 2w m08 a os a32 ao0sa daamwm mamnom 9mas a05m 310 3m 33am ou 3 (rma Me) 33F BLmeo aeddea 333 m mmW dm sBe 83 ;mZe6 amomw3s a wom 8 aw ms g8&" 2 2m 201 d2 ao22m7 wo 32 ao mom mae 8i EmCwR ae oozmmee diaemm o3wme aaommd dadme oaame aaasm aaammwoe adgww aw @ am ws ms ow Ba2B mes mO m28o5 Smaoma aaae)e aaacse 3oamee E de mE e de Ioamw dWwemm M aums Waam aaam wwame daaMm aam 3dwew oaamm aa3 3am4 a 3 dw am aw am aw aRd30Ea0 B 3 oB m R332W mO 6 W3a Bsaeow ddaaee dm sks 3aa E 3s aAda 3d 153 000154 [ASect 24 fRrS ares BODY WEIGHTS (GRAM) recom TTT TTT TE TTR TTR TEeeTE TR| = is 1 1 2 2 2 3 4 . < [IT ppm--wm i= zom=mr e zm=r wZmTm zm om= nZmze =o ee nw=e = fif]E I =Z==T 5 =Z2T 2 2Z=2z 2 =Z==z = z === zZ=2 2E 2z=2= 2 = ZoZ oo F Z== F 2Sf 00Bm Oom BBom OmB omOB Z=z z=Z == == BgB yo oonBwow BOE Bmooww oommwomm OE 8 oom mmm sweoopm B oB -- ooo&&mo o3o8w@ 5=8B oomm gE EX won 2 emma aceon) MH 5 5 3 8 B OZ 8gm===T f= ===om = ===om 2 =m== em=I=Z 2= ====em== == ====mo==z== E3EEFg om=0=- 0==zm.Zz =oz=w=z =o==wzz zoz=m= =z=== E===E z=== =E== Eo on mo o =z zZ =z = 7 ow om ow a ow -- 13BE00 oOmBEROOoBBmR Bo8OEmN 8XOoEBm 8B oOmB R 8Oom E$Oo9mB E B8om OEB2= ; [Ep -- EIf P T= == o==om == = 2=-mTe' = z=5mz%r = 2=gmzm z= ==ZsTe = zE=Ce=Ee z= =z=m=e = ===ve = J 88$ w=T m =oZ=mz om om =Z=ozw oo Zo==wz ow Z=oZzwz o# ==Zz=z = =z=== = ===z= = ==== = gm0mBomBow oBoomw w0H owo# OWN om ow oW BmBooE @BmBoOEoBmw 8oOogBm o@m 88om wom + g8] 2. ==== = ===m=== e =Z=zz e zz=== z=ZT= = =z = 2 2 ==zZzT ==zOE ==== 154 000155 [RS 3 -- MBoaDcYswExGHTS (GRAM) a 17-MAR-93 =F me= TE E ETEREETTR TTR EETE Ty -- B woooo 0@mBm 5000p @ooOommBmmomBmOooBmoooommmOoomeBooooommmm oooo@mmm moowoomm mow oowW mmw Hooonum aM J 888 BBm0mo8 oxmoBm.oOo@mBmBo ommoomm omoEomm omooBwB oBoBomBm OM OH oOmBe m3o@ Hm ou s emer wm wm wm wm we 88ge E mMmm0mBooBmBOoBm ommmoomB oopmoowmmm oooommmm om oooammmm om oooonumw ow woowmmum am oHooHlmm ou RBBA o0ooo0& mBmB EoBBBEBooo@BmmmOoomo moEmomooommoooooB@mooomoommmomooowmBn omomoB @m oNm88oN Bom 3 BPooBmw om OooBnm om OooBmm om ooOBmm me OooBmm ms am omORRo. m wm om om o@ mOoBm aw ron 88 8wokm00BB gm #@moo@m ommMoooomomomooommmmoooooommmmm oowooowmmmm oowoamew ow ooaoxmm maaoowm an a R88 00 oBW0mB BOmBmBm oommOOomR@momooommmm omoooopmrommoowooomwmm oooommmm om ooowpWw ouooBwuH ow om fom 8 00O00H8 om wm Bom omow oommBoom@ommoBoomw 8BOR2Bom o&Hz oOzB ow &&oomm ow 8&ooBm am =oOW 155 00 Notox projHect 202933 MBAOLDEYSWEIGHTS (GRAM) BwF-tuEp R- 4 recoveRy oniess 11 i5 33 72 i2 i3 PFi x =1 oo 4 E5+86] =wmon =sE e E= smh =mOmmm =wocmm =owme = oCae z.o=:ee ae z= . F2i5H W w m 2 o o os w m& HaoW %sw wowmw ooW ws To I - I om m o om o= E: = = = a8a w wo ow moomoomm owWwmm oWWwmw &#@0 &#o@0w @W @m o9 W@ a wr ww aw me aw we aw em wm wou 5 (ors) &&ry =m To osm==z ==me =Eoe zZZ o=Z Zoo=Z moz o= 7&&% =T o o oT s ==o-oo == E =ZoZ zZZZ oomoo=zoZZooooom==omZooooo=== a =o =z oz = = === 7% 352 3o9o7m #a0 m a oaws =I =Im --I-m = 1] wo ose ms a am am 73n 30wo 8od oiBr 3oH5nC B 3Hm57 d3a60m 3Wa6wm5 a3imm 39E W 2 R E38 wow & (eros) . 8a# =HOE= 3Entm n=m m LS == == = H8a =T-T ZZZTTT ZZzT ZZZTTT Z=TT om==m oo=mzZoom oommooo oo=m F5H&] = Bo= woz oZ omw Z=omm oZow.xoomxo= o:mZ IoI omImooII 5 Woo ow WW mom om = a wm we ws ws am ee 855 3BamE domme mdomeee omdmsm 3do%mm d3w m% sdamw dw3sms aaam 156 Noto project 202933 3 wooo 5 17-NAR-93 FBEOMDAYLEWESIGHTS (GRAM) : `massan =PA tToTrT TTT 0% T3 E %TE TwE owTE TTR R ETR oom 3 vacua come M B nai fm0B Woo moBomm ooBBmome omOOaBWm om mom Bo3Bm oomBoOmBe om om oa2mzm omooommzoooommme mom aw Bw wwooooooommE aoa8s RoB@OE Bm mOoOmBB wooo om 3B OOBB MOOBB 8 0B mBoom ooaBoBmm o@mo om omoamenw om SB$ F wo mBom omooA wme owms mowmm onoamw HOR OB OB 2 OB ow we ms om OmoBm ooOm Bmom omB moH BoB 2 ae 3 (rma aca) oF ZH OH B 8 = mnH moO eO omB mo woo oOBmEe om BBOoBm oOBBBom omooammm BoB OE OBR BBoBBm oomB=omm OB OB oooommmz oH oooomnmm om WB# woo ooo8 odd #28 odmBmm oomnmoom 8 o@ ooBhloRomooB @n mopooomm @ 0B oomommm omooommm &B o@m oo@omnm om mom mBooooOm om o|omm ow wm Hmom oOmBom am owBmm me 3oBmn om me me oBomm oBom m mooHm wok = a 3 (mam am & . EE Bm BE 5 = mBB moOO ooOB mnB BoB ooOoWmBmooBOoBmBm m w5OBm BooaBw OE Bom om ooommBms om ooOommmB3ooommma omsooommz om om om wBB Booo oO OoW Bm mood omoOdmm omimEBm omoiompB MW on m ooommm Bo2 omm mmmmM oommoomm om omomoomo onoomame o mom wm ow ms om wm aw mw w w Ho o om m m 8|om 8mow omoomm oownmm Boomm oowmm oom &m mooNm wom) G wwwooom oeB wo BE OomBe oBBOwBm OB OR moooRmB omB3ws ozoBazw omB=amm omoommwr OE OR OH om om =oiomm on 157 000158 wotox project 242933 a15o5nRa oS6 BFEOMDAYLEWESIGHTS (GRAM) wwee momToETff TEE0%E TRoyTE TE TRoE wnTR = 0 + maaresee cam)Rmee rmem mm oese me =ee =ee sesn #B &f$ %# = 0=TZ==IzZ =Z IzZ Z=Z z ZZozz Zz zz =oozzm =z ==o=o=IZzo=== zz = = BR = = Zz zzz. z= =z = 1w68 onWmooBm oBom oomm Bomm == ==- =IZ I= wom ow wm ww = oe B HBBoo 0om 8EBE ooZBmm omOoxHm Ooo2Bmm #Bo2m oBoBmB oEoBnmmB oom Bo&m mo=#m ace 3 (rma cae) ###00===z z==Z i === === =Z = Z==z o==z zo== zo=== ## 0 Z00=z-= Z===Zz- ==Z=z Z===z Z===z ==o=z ===Zz =z = o== == B Bo oB n oomm oo#m oom# w#m ==- ==z =T== F mB Boo Oom RnSoBwm oBw om moOmB oOo om m m om= wom o m om o mom BEoo x B2H OBmB o= om#5 B2 oB2 B o= ; aon 3 (ren acer) B = om im mm mr am wm owe 0BEx 1 T-- == == =oz = =Z=T = == = == =ZT ZTZ---zZT =-- &z=-5B- == =--==--- EB BnooOom=Zz =zoo=mmooz=mm= z=oo#=w z=oo=m# =Z-=z z==== === ==== woom om ow ow aw ma oe w8Boo oB0m oOBmB oBoOmB oOOmBB ooOBm@mo3oOmRm m mOB om mOB moOmH wom) Mm om om mmm me ae wm om 1#487 =--= pu==z =Z-_zT = =z= --=o-z - ==z -- =oz - o=z -- == 158 000159 | NoTOX Project 242923 FBEOMDAYLWEESIGHTS (GRAM) swT-mauno s- d7 meaner jmms=s 1 i5 oe - 23 12 is3 i3 20d =d EF0)d wow, fei13ts0 I i1mao ldoeme mim aoammm am ddmwmm Im 1Goam ow oabmms mo ooseaa fe Baamw im i3ouhs jie65 w TB mSom B odmomom oomB mWn omm omm oomm mn ao=o m33mooooonmmm mmO2onm i 15%5 iwee das oo domme aBs #o8s mo0y B3mf ome iBmS 10 -- ee ee oe 5 (eras) . 611a0 i w1w aammm amoGmE mooam dm dadwm dn admm m omsiomm am am aadasene 3 aa0m B oaa He a i6is&s ie im me oolmsda mB addaeew aimse as 1a1 om admoso ams 3m3e 3% xBH8me me ma3t iies w moodews iwm damk aIs domm dosa 33mm BbSe iimnn in m = wo= w m mam daomwS ds aaRe. omm ow omoomme amc ome om aoammm am mooemm Be aaaewy Be 775 -Boa= =dw W=e o Wm r im oiH BoE m:Re Goo 6 (eros) : EimYn 150 m mmo ooowdIm 1g aodddwmm 3damz a dmwdssmo lmoeom 1m aoiomamsn Hdwdss a0 ado8aw da iiFsso a 8m ammdem de nnnsas am a1a%p 33 aaas md aaomea ds aaas da 3339 se 0ah0e ais 618 wm Imme iamm aamy 1dommo dass aasn easa 1=82 50 W =me a= moda 82we dg iam m mom m wwomm am ms 1% oowmmc de aam mw iaamm hs i Bm we Im ae Im wp ods de bi in 159 000160 NoTox project 242933 FBEOMDAYLWEESIGHTS (GRAM) BuTr-mawnols- So Recovery op= es= i1 i5 3s 72 i$ i3 @d i 5 - kB13=5l0 ==m==m z ==m== =Z e ZIeI== I= = i38B # #a3s ms om mm osm omoomme =I= III IIIZZ II I i 1ei5d 2m0io8 2oGmm 2wo3mme mm 3o7 oo5o5m 2owam2 2m 860 m850 a338 10 _ = == ee s (em) ii0s 6 == s= o=z ==== =T =z ZZ oZ o Z ozmzmo: Z moZ o= 1i6165% = =-= == === === Z Z Zo zo ZZ omo oo: mm oo= ii6esn @w=o ooommme aoow wm oo=wm o=oem. =IIII ZZ IIIII m a aw as a wm ee ae bimin3d 2Am0e0 awa22s6 ao5m I2a3me 2Go2ym8 o2m8em am209 2BB5y0 08a268 wow (eros) 7mwmsn 150 - =m = o===zm z ==ZZ=Z meZ =Z I Zmemzoomz zoom =oz iird 1 = s = o= E=z oon ==== = Z ==. ZoZIoZooomxm:moozmoz=mm == = ZZ IZ Imo iitses womme oomm oB m om 0I II= =I =II m mw om wm ow am a a b158d09 wvineooidsm7s mm 0l4 m2a0s9 a3a8 23o1m3 aRp1 ee aBom5ee iiau1 160 000161 5 MALES BODY WEIGHT GAIN (%) momen ows 1 5 8 12 15 19 250s} } 2 25 28 ne 1 (mus camo + i3 os a om om om om om om $B5 0rBx B8E 5OB 30% 2#0 #=2z &og : : 0B 8 0B oF 0% 0% og & # g 7 # =z 9g =z : 3 0 12 16 28 3% o 50 53 58 i1 ToSH1 2O0B 3o3% 33 250 855 5 73 ane 3 (mae aes n EE EE EE 332 00E %B E0O%R 08OBB O0B% 240g 82 88oz -88u i 3 8% oom om BOB x om 0&8 ow ow x of om 2 5 1 Fry 30 B 0 o 52 aa 3 (ram ana 33i S0840% #085%B 0% 0B o83x o&o%&# 2o8 o8og &&8 3 SE #0 o o& os8 # && B o#BRwn3 o0W%W 3O% 0#W8 w"# 38B02 aes 8 8 HB % #8 & 3 161 000162 [ rox ro-- sece 20293) SRida Fic . BODY WEIGHT GAIN (%) TTT TEE ETE et e 0 tt ms 1 1 2 2 2 3 4 ` " are csr)ey mx 10 zm me wm er P P i PF Z z ZZZE E ZOs Z z ZO3Z %EZoooofz oooozzzz ow Zoooozzz oT ZoooozzTzoozo=oooO=Ez=ZZooo=z=o=zz : P 84] F2= 80% &F a.wFwom=8OF 2% OBR oEoOF nonooOZ OF Oo: oo-omzn om Ioz o5@mo =o= o=m gyo 02 8& wore 2 sme ses i3 88 O&F EBF Ood% O@5 0u%m y g }yp z moZ =zz Z =ZoZZm Zm Z Z==z Z mZ%Z ozm ZZZ Z om oz z zmooozz=a mooZZZzzzomo===Z2z ===== #yg $=%0% z=80z%% z=&ozm zZ8oz%3 ZZF3z ozzZT oZzozzz =o=zz ==== :; $8H 7 8C B%eTo 0x%a%n 33%e O#nFu F 5Eom 0R8o8- O3F = 3OF = OIG soB res ranm tions? em eo y zZ Z Z=T Z ZZzZzzn 8 Z =Z Z Zz Z Z z%Zz z= Zz ofZZzzX ZZZZoozzz Z =oZzZzzzz z =oz=zz=zo ZT ==o==== & ga HFF OF08 L088& 0O%F oeoo OO%F Oows nnoomn oozz ~ =z= - oozm = oo== = 09F %%% B5x3 2O 83&ow o8Fw OE8oBzn RoBoBmm B=0oB%m 3=0o%m wen $g oZ=zX Z Z=eXm ZZ omz Z eozfm ooozzm ZZoom ooozmz ooozzm o=== rez 000163 ad - Mn ass nn BODY WEIGHT GAIN (%) [T =ws ai i5 T 33 FY) 153 133 . a1 Eil 21% #83 $$$0B3 oxopy #B2 opor o# 8% 2ooz 5280&08%8 Ji 3@8 2cs E FBEE oFFER xB3R 38EF 5FOE5B &Fm733 Ce oe oD Drs woH8ore em sw403 88ooBm g x8 B3Bom os3o3m ooogzw . &xow og #& 883a 800oB8w a $2 8 0B o3 o& & #4 2 om 8n3n =o 281 woe mon ao sz i# $08FF 8 $so 8x 235 C$o O0E45 om x om Fxi8] k330 B33E2 oz on 8 80B% 3 &8 0x 3%m 83 FF ry F2x xOaE1 6x 8 5 8= 8 zx x 8oe O2oR =OF a ow I5 385 oe oo ##4#8 m2 om# OE %@3 163 000164 [Re 4 -- MALES BODY WEIGHT GAIN (%) maze 17-Mar-93 TT TT TE Tams 1 1 2 2 2 3 " ` 4 w88mi]a z=ms mz=z =m2z mE =z: g=eze 0% mom om o@ ===om ==z= === === 8g35 20%00%B z3030xm% 2oO%O%BW 2O8OW%% 8 2o33w =z=w=zm B o===m ow o=I=@m om o===m om 8 m FF 5.m 00% . 8 ox 8 3 o u cns f8 (mn ==0m a= ===ozm ===omm o===m =z Zozm =Z=eIm ZzmZTeTZ.o===ezz ee=E=Z 2(o F z=z=0s% 3===3 =3==wm owxz===. =zz.ox=zw =I===z =I=== =Z==Iz ==Z=EZ Roof Boos zo om om 3 ow ow ow oz z= oo = = B3nnEF 080&0&% 2$&0% &3nwm o38ROmB &OOFF &5BOB 0#ooH4w OE 5oFu wO30R% i a8on ame =mm = m= gE#8 == == I2Z ===m z I==m z &==m== = ===z =E= 8#8 88 ==T=43T T === T===wowo===z % B ZZzzTT== oo%w ZT==Z..ozII=z o=z =z= Z ZIIT ZEZ=Z == == : #g 003&%3 BX os E8%E om 2880BB ow ow 58w 35 z8&38% -- X3aI& 3@0a% 22wu:#%% 164 000165 NoTox Projoect 242933 FBEOMDAYLWEESIGHT GAIN (3) shgT-imaunpl-sd5 monen miaassw TTi i5 -_-- :3 i2 is3 Fr3 2` EY< %i Gow 1 macs cans) 552 1% QQ0 i2 84 555 3 i13t Fd21 ie B 555 2 i23 3 332 7 332% 3 i i 1iis%ad 0% 3oo 3 133 8 1P$y3s ia15 B35 i33s ai 3333 Fia] 5 ib@sY a i i1o08 33 73 o3 2Fd 3i 33 i3 33 3 |i i110s%7 i =o 8 0I5s 7 0S2 3 oiumw o11m i Fi] oF2my 3 2 F2 2 Fay x33 3i@ id ` ` 7 5 8 33 in - - - = ZZ 23 n 3 zEH 2 (rma scan) iim8ws 83 o 134 i 158 ai2 i23 3 bo it 232 F 2@2 i in@ 5 3 33 iiksd 12 330 3 3$ P]3$ i8is] 3 Fd aa5 3 i13 i3io 333%# i18 8832 ifeA s3 4 i3 33 25 i F3H i 3Hd iemrst 8: e 3o 25 e 7 i1 8 i i fr] Z uFy n32% i8 B 32 s3Fsy i EF] 3 33 Eiin -3 ssa 23 r 2 n3 x3 x3 8a oom 3 (rescaem acrraTE) 8i2es 5 o8o s 335 3 s33 boi1 iins Pd is i ia2 ii2 i is 37 FH] 332 3 foirst Be 3333 i7 2 153 5iB i3s1 FHii i] is i FH 5ii 33%] 23 3337 3 E7d 3 si iis S Ey8 5i 3Bn x3 i1bgsd ia Ee 3T o aTFr]3 83$ un ai t aiu 312 J 3Ey 33J 2 33 iias -=0 =3 25 r1ooxuoox3% iosm 3 x5 woma( ii1aes is 380 3 37s 1 3ss iis1 3B 2n F] 3n i i25 32 3 332 3 is 3 i 3 kd B i 3% 3 165 sorox project 242933 ngT-rzaunpls- S6 FBEOMDAYLWEESIGHT GAIN (%) ee eee e ----te---- pe A5vss i1 i5 8: 11 44 13 2i 25d 2H = ------ wou 1 (vmcze cans Hya" ii ==== === ==zz Z ==m zz Z m==zz ZZ = ==ez=m ZZ m z o Zeo==zZo=z== oZoozZ = =o: iird 10% S == E ==0z8 EZ =E z Z w oZ T w ZoZZZoo=oZozzoo=Z = z=o= zoo==z i 5 08.4 # = = oz = | iiiwan Fit =B3 0800o5m m=0HB OF4OaB = 0% 0% & 2Ow B =zOzW @OB 8o o=Oe BOE= or gog =80m z ES - = Gao 2 (rman ace) 2 2 Zz 2 = x = Hiwne Hi =====T =TZ Z==z Z IZZZZooo ==ommzooo==o=mmz oooZ =mzZ ooZ mm=ooo: om= ii2 a = == zT T0Tm Z=BoyIZ ZZZoomZ0zo=oOm===oIZzo =m= oIm o=mzom: ooo:== 83m 00% 0% & 0% z= = = = =2 50o% n203 f 0s 8 e wwom= =ooes mwom: : F#Fol = 0&22002@0B 08=2 05&2 0587 87& 0&380883 om 3 (rmarem scmam) B8Ioin 1 ==== = ZT T ozm Z Z=m z mZZZToo om=m om m==z=oeDm ZT ZZ oz Zo= =ooezzoooe::: moo: 28iHi I== 0==0%z8 O=Z 0T ZTZ0 oooTmo0=s ooT mz= oZmzo ooo mo=z oo:=oo= EH 8 8 7 8==== m 3% os ae ae friiiif 2==3 02302% 230B3F o8&f 6&9% 2SS83 o85m5 o25&m 5 = om ( iii1s T ===Z mZ = ZZZm oz mZ Zo=ooo=oe zoIooe =ZooozzZe omo=o= oz= =ooo= =:z 8 = o= = =z =m omoo=moomoo= 166 000167 NOTOXx Projprodect 242933 sweT-itkwap s- d7 FBEOMDAYLWEESIGHT GAIN (3) r-- t ---- ce -- -------- ----------e ------ =owsa TTL1 15 2 i7 is3 is3 2` Eld 21 -_-- or a 58130 fl 3 3 ii5 Fi1 i1 ii2 i22 F35 3336 sn i 333 3 33 3 f58e5t i " 88 mi3 Ss o33 m b2 m3i i7 =2 7 iE 3t n3a 73 o3@u 3 ii% s8 1i :i EF1] i3 33 3i 33 83 10 = ee oe 5 (eras) ii1se8 i 330 3 i33 i 388 Fd12 ii 11|5 352 a ii25 EF] x3zn o 232 3 iiiees isisse 333 o 343 3 4$ FH33 it2# i8Fs] 3ai 23i 3 233% 3 33@ 3 3 3 i fd he 5 i 8 iis x3 33 E3i 3 . m iimn o s un 2 z = 3 a oo i1 3i 1 ii Fiy 5 F3l 3Fy BiHn -0 =$ 3 23 T u ni ExH n 3 x3 : oom 6 (eros) ! iimmn in 00o 0 E5e5 4 u83 3 o2o 3 i2s i1s2 1 ut 123 3 2F3 5 3336 i EiiAsn isisn 33o 33: 0o 31 32i 3 12: i 1193 F83H] aa a23 Fd iiiF] 25i Fi 7 i 8 7 7 o8 1i 3i 33% %3 @a i11s85 fr1e% Qo e 11 e 32 1is i 3i 5::3 Z un n m1nF2r] ii5 op=my 5 Py 33 kl - = 222s 2i e ei xEY 167 000168 NoTox Project 242833 weT-trwkpas- s5 FBEOMDAYLWEESIGHT GAIN (3) _--m-------- Rev mmws 1i 5i po mass o - 23 23 En)2 is1 2i Etil 2:8 -_-- @oma( - 818350 5 Ee E eE=E Fy = = Fy E ZITI= ZZ=o=zz iffsdt io 4E3i) & &&8@ ii2 2$f@ =Z=T II=ZZ IZ = === 5 3 @ a3 w5 i 8i% %2 33 32 @3 i8 a8 88 5i 5i%s 10 em = =e ee oe 5 (ers) ii0s1 6% ==oom== zm Z=m == m ==z mm oEZZ z EZ ozm =Zoe om =mooe m o=zZoe mo:o= i1166% i ==- === won ===z wm === = zZZ ZZoZ==moxo Z mo oZ ommoo== = Zoom m= k1d6 ia F3y 3% a = =I =mz= imm in T i2 RFy 38 B2"E 8 =Fsye @ =BoomT 3 Ir5r 8o3 o w@e ze@w ii E7ds -3 25 =a 82 23 25 5ES xE] 05 oe 6 (rros) : i Ew7mmH 1 == ==m=T e z Z=eIZZze=== SZ = oT ZZoo=I o==xmo==o=o===Z ib8sr is S == =E= = T0% =oZ =T ZZZ TZZ ZD mZooooozzmmmoozzZm m oIoZoZo== i1s85 iT 33 33 3 2E == == == == 1i1s5m i5s 5Fvry 3 0F2ml 3 0F3Bl a 03m @ =5BowFeZ i zw3%r iEi ow3wzo=wZ3ee 23 i#a ki - = = 2i z # z3 a3x 33 M3u 1668 000169 Notox Projoect 242033 MFAOLOEDSCONSUMPTION (G/ANTMAL/DAY) em m= ys. 1maoo eas BaNaR mn1: Fe3-1m7wRpR--s51 secoveRr 1bd eaTSaRaa 3NI ou 1 (vmcLe canst) 133 233 FH22] ziin 33 3 E] i ES 5 wove 2 (ream moon) :ii :s7 2ii 323 3a10 iai i 3 35%3 ou 3 (reLaeR AcE) i2 2i3 3zin FiF3]l 3F3i0 FE] 533i wR 1iis FE7i 332 3i F2EHl] bd] 353i | wou 3 (ers) . uii ii2 52 33 33Fl Fd i ES wo 6 (eros) . i 222 Bin %3 33 P33l @ % 7 FH Z F] Zm e= T= = 3 3 3 Ey r7T e32m == == = = eE w m m Dem eo=mo 2 2 3% 5 3 ommweo,m I mmemm DIe=e i 3% 3% i e Fy sen m m Iem e FH % Ed 73 w=5r s=D e xi=m 7 Fd a 169 x protec 202933 ozo 4 AFOLOEDSCONSUMPTION (G/ANTHAL/DAY) samo BP B r: om 1 vs cannon) iH[ y E a z5 on 2 rma mon 1I," == := wo 3 team ave 32FETa=% wom Fi #2U0 ==5 [np-- a7E 2 z=7 on & ron no : E2 =7 retun 01-MAR-93 } 170 000171 NOTOX Project 242933 FFOEOMDALCEOSNSUMPTION (G/ANTMAL/DAY) momen m& =ys C Fi T eas e isa aai owe 1 (vcs common) PF4 Bn E1F] 3 22i fr2B F]2i 4 )a i 2 2(rman con i 233 FHi1] Fa2H] i2i 228 3 i a EE Go 3 (mR sc 23 21 12 2i 23 33% i1s FH2] i3 ia oom 4 332 FH18] 222 2i3 n3i 8 Ed 2 E a cou 5 (ers) aa 8 12 B i1a 233 fi2i @ Hd 2 3 8 Gow 6 (eros) a&ws i21 80i] B2i 821 . & HS x Fo HS rSeimuoRe-s33 RecoveRy. F in EE : T9 NR =53 om n w E Twe we = 2 3 FP Wt 5e n2 =m m I= =ID & 2 2 FH =ZSmm woem w=m F2l F 3 ER2 F] 3 ea 5m = = 32xa o Fy Dm n==mm=I i32 a=s3e n sme =w=e ==me i2 171 000172 Horox prorjeoctses 3202933 FFEOMOADLCEOSNSUMPTION (G/ANTMAL/DAY) recor == mys Ea1 owe 1 (vaacis common) . iii= -=nn orn 2 (rere acon) 2B Z=eze #5 wom 3 ream acme) 3in =E--o i= wma 35n =---- @= aon 5 ors) : 8iaa --I=-~ i wou 6 toro) 8i ==-- a5 reenR]- 172 000173 NOOK Project 242033 R(EGL/AKTGIBVOEDYFOWOEDIGCHOTN/SDUAMYP)TION MALES GROUP 1 (VEHICLE CONTROL) Rereet i+ 3 monar oaa5mrss m1os eas sSah ads 3i1 11n00s7 a]ame E5aH] 55a i male a al RecoveRy. iun Z5F e eiaAsg 1a BR 2ew3eo I=mZm ==em bs 7 % : Recover atow=ss aim0 331 ==-- i 7 173 000174 Noto project 242933 RELATIVE FOOD CONSUMPTION M(AGL/EKSG BODY WEIGHT/DAY) GROUP 2 (THLOMER ALCOHOL) manor = mys imeoweass saBaR mas: 5i5 n 1m0w5 eaa5m 255 033 i os wm 5 = & ows mamt 3si --== 3 areS-itRwaol-sd2 Recomm iin w5aw 5 eT d ih am mUia m5Bm. m=Iemw Iexe=e 3%7 174 000175 =REERLxAGTIBVoEoFkOWORDLCCONISTRMEP)TION , Grou 3 (rEzouERACRYLATE) mo oEws 1-8 81s isa 22-28 ro 18 eas dads 193 I 8 88 82 % | pr gg=me oF ij] ===0% 3E 3T%T == =3 ' 1s 000176 NOTOX Project 202933 R(EGL/AKTGIBVOEDYFOWOEDIGCHOTN/SDUAMYP)TION MALES GROUP 4 ( mone teowmss Lmaoo eas asBaR aa iinse m m mo a ow s i a5a 3P0 bd Et 5 5 E] Recon n= oess amtd Bn bii] =5 me(c-empit4 nocoveRy i1n8 2&]: eaT d dO ais eBmR Emw me =am== 77 176 000177 soto proface 242923 RGE/LKAGTIBVOEDYFOWOEDICGOHNTS/UDAMYP)TION LES GR5O(UPEPS) neSeimns}5 =wBe omhr eR 5w P3o0oom 00m@B oo80mm% aoso maiWoo me Rmoy d BEw"R o2n 3m m8&2% m H5n O0m w" 2T== 2.8 wm : jo==ve Ea4 P3i BE o=z% 177 000178 NOTOX Project 242933 RELATIVE FOOD CONSUMPTION M(AGL/EKSG BODY WEXGHT/DAY) GROUP 6 (PFOS) meme wmss 1w8 owes i5N2A1 2338< F2o3 m Hneo a ie a w %5 w25 a moo a5 Rocovezy or=nss i a33 ==we a = recS-imuuApR-sS6 recov 1na eaTa en 1aMR 2 % 0wTom =o=em 8 & 7% 7% 178 000179 Rf(aC/tEGepsLooFrA0w0DeTCxONIGSoaTaVErtT)IEON GROUP 1 (VEHICLE CONTROL) oes EB aSvs BTe seas 1WaE 222- i088 #8 i oB =u o soEmE x3iu=== = F #o EeET EE 5 0% uw 3 179 000180 NoToX Project 242933 R(EGL/AXTGI_VBEODFYOWOEDIGCHOTN/SDUAMYP)TION FEMALES GROUP 2 (TELOMER ALCOHOL) Re1co-imapnl-sd3 one a mmess T moo i eas s saBRa aaa1 i3 WwE oo Edaem To3Ew o2m 3 WB sacovmmy i1n8 elTGaRis aMaE eo myr rmove 10% 3 I =te I=wm @5 i mecoveRy $ omwss Em1 332 ==--~ 3 3 000181 180 otox project 242933 RELFOAODTCONISQMVPTIEON F(EGM/AKLGEBSODYWEIGHT/DAY) GROUP 3 (TELOMERACRYLATE) mw=ess iWa HeaOs SsEar aa1 3ni3% PmmW r ooHmmOMm moWmim socom om es 7 a i3 --== i5 nefornei- )9 ai8 eadTMies1y 19M3E2 = Wm| o= omwe B05 =a= ===e ww 181 000182 NOTOX Project 242933 (R G/KE G BL ODFYA OWOEDITCGOHTNI/SDUAMVYP)TIEON FEMALES GROUP 4 ( ec-[zuop t- e10 mana waess. u1ws eaas oe n33 LHHeo eiaa0: Ww sSah mas` oiCmh EE]iooe me aw RacoveRy awn =--15% ea leeA asia m=ez wo mZ e ZwIeD 55 @ } nacovERy { aoSwmass amt 33 =-- 3s =a 182 Notox Proj4ect 202933 R(EGL/AKTGIVBEODFYOWOEDIGCHOTN/SDUAMYP)TION FEMALES GROUP 5 (PFHS) arocaur--5151 mone mys & imaoo eas Baz mea: aa8 imBmoeo wMwese aio0mw aodeme a mW om ae ed Tbed i=winrn eas le9aa 1U2 i mo7em m=e w==e 5w W sscovery i o=ws mas1 a48 =--= & w 183 000184 NoTox Project 242833 R(EGL/AETGIVBOEDFYOWOEDIGCHOTN/SDUAMYP)TION FEMALES GROUP 6 (PFOS) mena io5wss imeoo es asSaR mam0 ia m00s oa5w7s 5a58m o35s @ wow ab aw o=ws aa1 &8@ -== a Ws areo-immoar--5132 secovemy 1i8n easTiA e 192Va3 EZ 5E owD= , = 103 3 0] 184 TNEOLTOOMXERPrAoLfCeOcHtOL24/2T9E3L3OMER ACRYLATE/ /PFHSIPFOS KEY2-2I-NWDAR--951 KEY T0 MISSING VALUES AFTER 4 WEEKS Aa1n13,4t,ea8l41,991,,5721,,4958,3,, 1946,54,, 56 177, 179. 120, A6135n3,t,7e2a1,4s1,,77,3632,8,,5751,698,,59,89, AAnnitneaall 1622,5 174 A26n5.t,e3a667l,. 2,7401,17,4792,!18,30,19,79, 7. 88] 89] 50 Anteal 46 and 59 AND REWARKS HAEMATOLOGY / CLINICAL BIOCHEMISTRY +o = EDTA sample clotted ee x Citrate sample clotted +"1+2 = PdeIvTtaftninpglacsumravenotnotreedprfoodruciPbIlTein plassa Serum sample showed haemolysis "+ = ALAT 10 serum not reproductbls AFTER 2 WEEKS RECOVERY Anteal 75, 169, 166 AFTER 4 WES RecovERY Anieal 14,29, 61,78 Aatea 127 <-- = Citrate sample clotted --- = Citrate sample (partly) clotted +++ = ALAT fn serun not reproducible 185 000186 Noro Project 22933 AHFATREARTO4LOWGEYEKS MGARLOEUSP 1 (VEHICLE CONTROL) wSeohgRal<s3d aoc: mans RDeomw TmaMc) wRan weWr OEnev o=x wmo h 1F-E2 = 2 2m PfoiomErs d33E HooaaTEnmRo 3s3fss 3b oB0ooooeemwm 88ow37e eMFdEm ow BBB1yd0 HmImERe BiH B#m3Ds BY oowu dw oes a@Bai Bd diMimEa DE ###331 BI oowws Bonas i ME EBDE o n owwares oz oz pmr3a BT BobEmh Re BBBBYUiYOBBBOmBB BB3Y0 BONB mocctcor manarms : RnmeomL o wee fseo. B. mso. [= Loo. =3 =3 - i i T=z T, io o=T =z=ZZ o==wmmooDoI meooo=mI Zo=moI om==oo ozoEEaEEsDOEEmDds : T8 $0 omaomimse dEsTaheegs odepeaoewse BSpaR%w Se MGpEEaRRs BER BdoEmEYe GR B iMd3a 33RiiIa BB03 o8a5sEMFE oooodlnmses ooogioboehss dbdoRow dR ooowHwe SE SdoaRew GR iMit3gs M3 iiiSsh BI #H0 ONS3% owainm hoso oceasw oooenm bsaase diFa 1isd 186 000187 Notox project 242033 AHAFRTMEARTO4LWOEGEYKS GMARLOEUSP 2 (TELOMER ALCOHOL) BaxY-omoukpAal<s2s `mBaToLor aAETERS amamw TfAc m)an oir wT= T=e wmen 6Th aFAre ComBvoo ooeEeaxw aaeda Bs ea eeoasm38Sa3y4 I1I3nmme mmmass Bwiaaad eam wi lia Bn ua 5STM2258 fi B22o TsEmmm sasasp iowa 8d oeoidas s1wai IDmmidee BmBrSa h8Hi3d bJ59hB5 oar m7 Di BE hd ng . y i inodemm saals3 Boom 93 oeeladmi 8F3s egs ds imidmnm EBBoSn bie EL n#uo3s Bn aHS5eGa5i7 i Bem h a8E3 eossl sSmh IIddse BBNs nLSn HhHo mnarow pasETES eammau on T=mT 7eo. w w. p? ean E7S =or ii1] 3 w7a63 73 ooomise oo0llo0aas oooomom oooooaiss ooomsmem aiisssse ois ool oo ob oom ies 11156840 isd 332 mwll3sd a0 oooiimsd aoaw0os oooowmn oo0ol%ms ooossasm iiivesed 0G ool ob oo oes dhe dd1ee3sss ine 2Z363o i mdal07s 0 oooldeoss 8 os goglooas ooly 9oo0md0ee oom godoeosss oad oooeewsme oom i11e3gs3 iy 1di6es3ss 13 33 WmS8 eolBe sglmesd 0000 eomosl ooaed 1i5sa iisees 187 000188 NoTox Project 242933 AHFATEMEARTO4LWOEGEYKS GMRALOEUSP 3 (TELOMER ACRYLATE) Ene3e6o%vaono<s33 --_--mm------ nares paneTES -- mamaomy m5h mian wAr PTo eT we maN n T r SeA r 3 #3 0o& eenm 8seal kw a oo0de3 od s30e B30 D1iadase nmms33 Ins ng BnnEad id nm5g5u7 53 : 3B oom &ems ae2ld #0 oi sd eeemwwo fsfssn cas mi iIImdEe mBBssy BBn3i30 IE BS 43 BBdYRa HN i:| 8@@ 8 eewmxs em 5aaaa us eSoaawes oe mB BsS id Iidws mBBoSI Zi Im BY nhBsin ni HdsYist oe @ e 8 xe ooaan mB3E iIEn BBEY BBUi a5f00 -_-- 1anancsy panes -- enomn i-- -- woene ---- fs.--=eT-- . S m-- o. w-- w. o-- eH. =P-- r =E-- a 33Romessis 3 oda loelamsm oodlodlsee oo00do0 oi of Sam oooioosmm cox ooowssses iGnee oa 139 Bm=as Bs 337 @ m32k6 93 oOolmlaes low ooooo%mls oli 0Q0%e% 0 oOoooamm oom oooesamr ows i33a3 ine e1b4gid ies 8@@ $0 uond32 wa OooEes oul oo0eo%s 90% 0oooa%dd oan oooooomk cow ooommeee bas dBBaai 1d iiieess i 8@ 87 ooss odobeis 00%% 0o6sxs aoseis diesd bdeed 188 000189 NoTOX Project 242933 AHAFETMEARTO4LWOEGEYKS GMRAOLUEPS 4 ( Ha3w0n3-s3o ET Ba pens C an_m--mow ec man ienr Eeyr C a= mm=im n o8 n oeEa z E 2R ee2xmsea7 ssa af ee o.4a06msmm34 oa sels D1IEmaee mRmiie Tad ome m#W3Ia ng wBBRRm don | 5 $#00 7T 8 Esa8l $ #0 e =a oeeases Bsm7m70e od = imitdnmn BaBSly == =iEiIHn =bh7pi oes @1 ins | d$ ioeg8 ds 8ea & es su oooueass smasee IiGe Bmmois DRE BY naHuaas BI ow 88860 eas @3 I as Bi 532 a am a odes sz aE E30 Bi a --_------ maroc panETEs _C mameo--rm, on = 7 mF m o. P a w. ti een ==m = =wT S $ & IH dme 2 M3 go0aagmm coe d0o9oms ow ao0o00p0 ob oaoouomms oo ooomeeems ows hMagss 1a eB1da7 deo g $i$o mw8e2 oooculolees 2oo9%eo0sl 2ooo8lbabon 0o000okx 2 oobaoaki ou iA1e3d De i2bae as i $8 a wmWaen. 9% oooldeas Qos ooolloee obs oooolope oom ocaooolss oom oooeaasnn osm oDDoes es =d16673 1s | a@ uTze ooelme agooless oolodoe oowos oosemm 1i4sg. aSo ee 000190 NoTox Project 242033 HAAFDTMEARTO4LWOEGEYKS MGARLOEUSP 5 (PFHS) wegen 5 asaroLor ANETES moaenm aAc )man wr nEedv s F8E eucsEx 7so1 %8a. TTaaen as8fa% AB nE eR w Te weoslF 7%nooeefmRm a8a3s BBem dm 580d 09e33g sd@ms3a eeodds36%313s oeededt BBS3ed0 oooiies B3gs3i ooied m5E a=r omien o8 v 1rIadmme maaese ohumide TIDaiamme mBBozon oc Bnhons mIiimEme BAAeSs iBaE IIimdFes mBmYeu MnB3sg iihm BnsY Ehda E[srer wSsnii a356n75 ai3inl wi3nG &21 foaimos vec a-- 5T%. . m7 o. w e. soem. w=m w=m &&gan7833 ooowdss ocollsoes ooooommm ooooownl oo0ness mnaa --13a J&8 m$7E3% pgdlaansss 0ooloe0iod - 0oa0o0mm o0om0oamm oooawmkse di1esad 1bIsad 777 B3w3i5 oeOlalsee oddaoosoes o0ad%0e oooooommk oeoemmmse ls ig &dbaad 777 aa831 oGodlmes oc0le9os%s 00o%o%.m oooonomam oooewssss mbag b6paa7 7 S&o5 pNmE Goedls oSoemw oodleess eomeos oIoT == 190 asBmmrEaoO6zoecerros -pre-- nn NmemraexL oBmeEmWn LBem W wErH F mF av Om= Bm= = P== T PEW ov `Pareies oo 88 8 moE oR Wom o pfr Bosom BBoooMm omm ommow JE mmr Bmee gHa l OTFOFF =m oPPEE TEE FE 00EO0L8 dHEOEfm iHmm osfm8 MSHm OBf MBEd ie 000192 w amdm eT `GROUP 1 (VEHICLE CONTROL) m mmmorw a HmOm eRmR EBE FF ner E omu mS "w,a F Www rm amen #3 3 Eoin fm oBs me Eom om ogmomome om Lm #8 oso om oH Box m o_HOoma=EmoEnnTpRm RR REnH y -- -- -- oa om BO8B iooomw ffmi 8og HiM oBH oOH 192 000193 NoTox Project 242033 newS-zauno s- dg AHAFETMEARTO4LWOEGEYKS GFERMOAULPES2 (TELOMER ALCOHOL) ----------------,-- Some PENETERS s en--_m--me_-- mRae man wir =T e w=e emied w8 w maame r m wo = rsa 7=x2 ne 8 a7 oo=am m8=:a 1D=mm om=@as ems gm Bi W=was H3 i=wna 570 fnwe eoenesx 35a3%s mo en Es oeedsen SsW1se ea sa ILnaimra daarre IE WNL hH2dd3 na HHanEYe da mmmoo oeef]sn ea8a3 eh a7 oooede 3m73a iI idmm 3Ba3Ed hLHnnE BdBoNYy ee Eh IN We mi ie m is os6% a ooiee 3sy iimw BawYe EHhy? bie a-------- `mBoroLoor mvETERS enmxos ovenc 5T55. . n m wo s2 ees m o Fr. a sf e mF moE eoe ]s FmmE.ooosue I He .5 =0S.h3o5 O30.%0a00 goonooss lOlalaodss oooloeens o0al0oo0s SCooluses o0Ol0ld%d ooosls ooldedss m o. WJ ao. 7Loc ek, P=L 0d=.e00w0 bio0s.0o00 o2o%mess dfmreiase gooooam oooluoasw oo0m8se% diinsis lloalaiaddn aaooossl oooesas 1a33ae3 dalodaddwo oooobbmim aagsselon a1i3saa Doolded oolobimo ocsams Iises eee "=er 162 11135s iilesd Bi1as 1HB4ea3 193 000194 Noro asec 242933 AFmFEmTuanEtRoess&oWcEyEKS GROVE 3 (TELOMER ACRYLATE) wEoE o - 9 [re------ EaDEoL OREMC R" aWwT mooFv POaB = we vn ROW Formers BBB BoiOomdmRroonMi1 0 eogrmmumomomMeem Boof28 dm Er mmbfemmo oBBm yr@o omonmni omom=me HE OB) oom BB BBBoOoOo oEmRsomoonnnomoWoMkoRomERBnEEEfoDmommHodmrEpreoaoomRrmm o1m3Booerrkomomo8eee wFBBOoooooofT EseooooBmnA urMomAanEM3O mobmm noE omBroomome@ooomums matzo: manera mBmoEl Wweme S8OP6. p.opemo, rowo. meLoe, [n 3 m=) - BB BBPo EooOEdnHEmRmeoM ooasEmmem oMoommwe uouE lmm E oosoweme T8nBr1o0wEmS um oem oo B F BFOE OE OECA dEI mw dmom oA owm omemmA osm oem mr Bn ud ae M WWB BooOoo W oOsdH3omo ffdmmm Rodoof mEme ooutmmmm um mwsu osrlmm mnssoaem esee mndBaYrrn iiuan i 194 0001: NOTOX Project 242933 ESm55an-305 AHAFETMEARTO4LWOEGEYKS GFERMOAULPES4 ( ------------------------------------------------------------ eNoomn Ame em me eanemAe E e mkey m e=eeeeeeeemeiten w webvene roAeees Fiusr emS a--e1 wow 8g 0 9-3 03a sg--do. 3 LI-ass mm=an INS an wf=ls ons Bm=Yw de miFomr feww mea. asalde oo0ee3sr SsfEsn es iiTwma aaasl3 mwndan ide WS i nfbhgn be m mmo e em n3 a8seu moan 8g eeoameee SW7eG oa 3 IIidmEse BBWSeB Iam Bu WwiSSd BQ bHHeaR wBo ek8% 8as oeaes s3mi Inaimm Bans fHdn hBEE --- maces; PanETRS e mn_oa--o_mr-- oweh wsf . 7. [ e E NT 7 = = =or iuwgss is l72a11 og--oomn Sion od=oets ol ol--oaom oom ob=obmi 00m ob--aaw caw i--iieas iy li--enee leg jio1sts 5 8S&53s5 dgooooenms ooSlloaalg 2lo0omm oooddaisno oooemsses ii7ead dom oldie ow oss is 1118ss3 1f fBeiE 5 7$7s3 0 ooOmrs ss oom ddoaeldsa oll 090%m% lads oooonommo obs oooeewmms ome idesga Is 11164ads dee iif ssso cSlloom oolosl oSllalm ooddids ooesso deaed idanrg 195 000196 HoToX Profect 242933 AmFATmEaRT4oLWGEYEKS GFERMOAULPES5 (PFES) [ Toad oncsooy mavens R Wmmeomw mWeM mm man rW A Fnev =EE E R NCE i F i1g EesRm ssse eelateA 8e3i ILaEy RA mde Bmss mumy 16i i @5om goEps grR saaa16es i fw sn epM03hwMse mEEsinre oh Es M1MM3EE80 aHmdedDte BBn1Esg7 LR Hi RS oBonmRmne BE : mmwooooooegE@moosoeor woofs er ooeomwd ed m8Rn3e an Mi MBB RT R30 m8 in BHByyl Be bBuYem Boom oa om 85 MHD Bs oa re eet------------------------ nNamm w5ee i@1 3e333 i i ado7an2 dw i io sr ng87s m mmoooOE @33 0 BFR sm. wm. om oseeesahoeeeeesss Sodsaeee bdpeeons oooowshmss oodBoeaeemns Gawieems eooeesm me. ww! e m em Scoeoemw A oooeolsm ne 0 ogmmep eas ooossSee eofsRe fm ocamms 8oSom%e%e SS spaREmSE ofosime SGSowRwe odoaEak goieemm EE m B am e nbnona gmimoe HBHiSa 8BB1dd i3mneLe3d, a iMd2 fjMeoit dB#eS3s 196 000197 HOTOX Project 242933 AHFATREARTO4LOWGEYEKS GFREOMUAPLES6 (PFOS) wmwSoizaDn-5132 ABOTLOG, PRNGTERS e ma-- maesm,_--imhmmm)an eI r =T s T=her wmien w8 n ames iimsom I2x3 =iney m0 im is =a=0 =s=e ee =i=a =2 = pr==ed ise ma Ba ==El ds mmiooo oTns3 wassse ms en as eoosess 7EEEs east Es iIidddmme daa3nd IE do lW3da Hn iBBwhR BS : if fmr r ge ]a) Be Ss ws eoenNdd #omm73y ord IDmmEEe aAAeGe ds as H5HiY8 dn NBHgpE dos Boom a od We In WE {3 BR --_--,,,-- `oro pNETERS mmoesm, ovanc seTs. =T . 25 0. o w. iF=Y= - mimoo imo Ts S=--ess = =a--oe = =o--om = =c-aw = io--rss = wBn3ys3 wy 3BonSs Wn 1in is au4il 9) ooioooms oSolloaasn 0ooog0m oooowoms oobeesss iiiga oios olan ge oo Ooms ia 31607s9 308 1is88e5 18 3737F oooolloi ooolooidd 0oaod%dm oooonooo coagoaemws iiegda glo ol oom ogm ose ded Idiseses dad m1500 4833 oloml ooosl 0o8o%m ooewss ocsaesss iieesr deeod 197 000198 wozox project 242923 AFHATEEMARTO2LWOGEYE.KSRECOVERY GMRAOLUEPS 1 (VEHICLE CONTROL) we8eaan-3133 moron: enerms Mmoewm Mm 0 e manm mW r Fnev == moeE I kHaAs TES @B5 0oorezdEe os3s1 ssMuwEe mBsEey MiMmMEe #omm3e Baod1uoommmm A-- r -- -- a -- ------e --r -------------- MJ am Ee8e7 eirta eI ms e we ee I pd eeeem=etOB tt BB5 a008381 oHeoaElm MosmoBsw oMs4oo8w 0So6oh.n SfomEm HaeRes BumYda 198 000199 wotox project 241033 AiFmTmeEasRTo2WLEoEGKS RECOVERY GROUP 2 (TELOMERALCOHOL) wSc3413 ----i--mm--Tear--r-------------------- Tr mwEoeEs om moER, E BF e r T=pE ee= ee etv setB e ere BB3 ooaoemsmoRoonMss MMeaEgm oommaBDomoiMmEme moommBa3 pomw2omoosmm eesarmarnrmornee-------------------------------- Dmme oxe woE mm te TB ix --R----e--e -- ----e peFneeenErTeEEmeee BB3 OoOoNwrsDOOME smEn om OooMm oueommm osoooomwm omommmee Eommeaa momee 199 000200 NoTox Project 242933 AHAFETMEARTO2LWOEGEYKS RECOVERY GMRAOLUEPS 3 (TELOMER ACRYLATE) mes3I8u5DHan--513s nao PeNETES awmma Tm A emm an iwnr wEed . a= o=man Ie "Aeames &a aeemmm 8a8337 o09a3% Elsmsso Iiiaaimna aamsse mBbaYas uB3Ry% -------------------- : mamaomn wGhemf mmm. e. wT e. e Se w E=m 4@ RmB33E0 ocobeeslm oeoenms ooooeoo eoooGmn ocoaesmsms ah1ea3d BMmSsa 200 NoTOX Project 262933 AHAFETMEARTO2LWOEGEYKS RECOVERY GMARLOEUSP 4 (1) `mame ems Mmammo TmAc m=an i 5B 90 en 9ekm s6aas7 oc0a3wsme _-- `BaroL0T PANETSS _maam--mo aan 7=mI sss o; lado ocseossms oooeoosm new-3z5NaDR-- 3156 eFde =we memwa m n SoAws mFmies mi1daaemm HammUae HBm3Is0 1HWHRm 7E ,, -- y Z = = =FE 0 oooom oocooamm ooomasasn Diies8so 6h1a23 201 Nozox Prefect 242933 AHFATEEMARTO2LWOEGEYKS RECOVERY MGARLOEUSP 5 (PPHS) WE-3z3NaDR-- 3137 `meat: MANETS mamoms mmhe mwan wir nxv anoeaeseEl 88e33s oeoiise HsWeeIe o=n m =abwo aiamddsem mHmEsi NMaEp0 aroe me BB oro paNaTES aammen owhe f= TR F N = = 77Z%s amaT Ti om ooann Soobhoie 0goe%em ooooeoms oo0assgess isss e=15e3 202 Norox project 22323 [eSoTn]s A`FETABEIRATO2LWOEGEY.KS RECOVERY MGALRES6O(UPFOPS) A ----s--anar--oca-- r maw--erm-- s ----eees------------ = Maaome Tm M-- Wman CW E FE = = T EFA ) 3 8$ 00 fex e88s3 MeseEdm RmBEaIOIMiWEw fBmfIa Bo1lu0 uuwmem --p mmoccr_ uoeo;te-- ewets-- t -------------- _RNmEO--EL m wee fSs. 80 00mH%aE aaealEs . ms o. M2 0. osoeeemsw ooolaw SMoeEEm LogH. = oB r E = oT doosEmm HBsyee Mi10yns 203 000204 HOTOX Project 242033 AHFATREMARTO2LWOEGEYKSRECOVERY: GFREOMUAPLES1 (VEHICLECONTROL) um30nMAR1-595 -_-- maoPRET 0 ma_F a--mw mmhe =man =A ES m I= omien VF ooFr Aarms 1iFeCs n1nm 3ee c 0e3dmeassmeus E1RaGGm mBBLaID OmBHYe? wm 8 _-- mamepmeTs mmaenm _-- woehe = f m7 B e. wT ow. ei nm ES = =3 ws wr 5s7a3 o0g.sm9ss5 0ool0me0es 0oO.al00da0 ooooolnm ooosmaem 11 1632 3h1i7s 204 HOTOX Project 242033 wme30o%D0aR--5259 AHAFRTMEART2OLWOEGEYKS RECOVERY . GFREOMUAPLE2S (TELOMER ALCOHOL) _-- Baroy msETERS m Tn_em--aoms TRahc m3)an wr ESnev r == wmaaen von orA es m mmo oeosesw awesds eo0mea mgmdEi ui1am3m BmmaSsn HlowEde BuRm -_-- `mace maweTmRs _maam--ma Gahe F = E C[ C = TTT m =-- = =Fy iimzo 1sS9s6 ooolooekms ooaloodmss oo0.%o0e0 oo0oo0mm% ooossmem 3aads HHaife 205 noTOX Project 242933 AHFATEEMRATO2 LWOEGEYKS RECOVERY GFREOMUAPLES3 (TELOMERACRYLATE) EM-Sat-Dwa-n-251 naresPETES == _m a amousmmE m)an w G1 e Ey a r = msaen em wSF ma om ws i em eE888e3s o0o4md2 3WgtEs dI1aimge B#m3da BRisIYs 6u5s25m -_-- maroc: sas i _aammo--s voarc T=. =T . mCCso. CwT o. TmPw, m =on = w=o jkWeeo a4sw%oo ooollemss oooooso oocoodwm aoonoos ooosmsese i116saae iHseesss 206 NoTOX Project 242933 AHFATREARTO2LWOEGEYKS RECOVERY GFERMAOLE4USP( Wew-SozvmDa--3313 -_-- moToLoot mars _enmmo--s wRamc mWo an wIer B=E Bm1m ooooennm a5se 0eedaaee asedaa o=r imTomen von iiimdmses mBBaSG fmWaSn Aams HHaBRe ------ mac PNETSS _B TNao--mw Gaeh f=mT Be. = w w. t een m=n E=a m EoE a8S ooolnossso Oo00ll0ses 00al00o0%e0 o0000oms ocoamwsess diiesedis ei1egs 207 NoTox ProjH ect 242023 AHAFRTMEARTO2LWOEGEYKS RECOVERY GFERMOAULPES5 (PFHS) new-3ziNzp --3233 _-- 1aoroLoot PETS _F mmaa--mw TRAR m)an wis nr Em i wSo mw' anwwb oFAoes mfoeo Eenm es8i a ee0ad3eem #sm3ia aiummdee BBmoYne BH0SR i=$o8 -_-- `mnaroioot mmeTIRS mmoawm _-- on w F mC T FC C P m = = =Ea m mwom E3so ogo.lw0o8 oO0.ll0e0ak8 co0Bl0%0o ooooomm ooossmsee iios ei--da 208 fsoEotEpTcA-- `GR6O (PU FOP S) HRT ET DmmmoouxFmIacE mEm rywa WwB rOOE PF= O=B D S= oTrTaW oaFwr Ha TEES STEnn mnmew moemL i eHwnaOB Om Fss. PEiP.m PmiEomO , mT i0m. Ocw[ m mPE mBe 2 Emmao 209 000210 oTOX Project 242933 APHATREMRATO4WLOEGEYKSRECOVERY LGER S1O(VU EICPLE CONTROL) _-- Pr- em_a--m_w-- oFmc BnBooooo7mmR S3 V wr a5es oo0sammm Hm-3z0u%D0aR--5255 wT= ewe =o = wmoaen oV n wmmsyo Ea1aeam B Bmis IHiwda SmAame 3wS%6e1 `mao avETES -- aamamr woene -- f=mT -- Bao. m w. wBoo aBBEEo aooieEs 0oo0lo0e oS8oo%m oboooasms ioaE n = B =or ocoesmsm wo 0 bs i26mas 210 NoTOX Project 242933 AHAFETMEARTO4LWOEGEYKS RECOVERY GMRAOLUEPS 2 (TELOMER ALCOHOL) HDS0DTn-- 3256 enmemw mFamc a FPI ER TEJ --.--. mon H1e4r nev a+s1 oa0em3se6 sm3a3 w=n imoien 0 maaaEm BBmiEo BuBIIg vaores BaoEyn Inacio panes mnmaem. mGne f= m o, w w. 3poe =BE =Fy 333 m1300E73 oo0adak%ms 0ocdo%dw 0ooo0wm0 oOooasf oooesess BBay iiaeHs 211 vorox seesece 240s waSeind27 ArmFamTzEmRzro4rWoecEtKS RecoveRY GROUP 3 (TELOMERACRYLATE) e sree mae na e. pEr ONRac ee"O eeewBr OFmv f a ewn33 iEwmwomEmrt uoom Roormc,,Vwveommamas Mm1EEm BBmrrY 3B npe Ouomm I --r oncee mana s oee m--s epr--m ------ = E =E Amon wee =. . G umHe ONsMmE ERsWeom IaS oOsMomR. EToMevoTmm. owreaLommmo, nw mm oom = oomram = wormrg BE - 212 000213 NOTOX Project 242933 AFHATREMRATO4WLOEGEYKSRECOVERY GMRAOLUEPS 4 ( wo3r3nTan2-393 _-- `moarooymers 000 me_omw TRAa man C w in mFdW =wem e men m gVen aHm ames aaa saTwnd 8ss3ad ecoaaeme s3seee i1E3mEs B3w33a0 BmBFei mEHmRS _-- mnaToucoy maser nm_em--me aonc smT . TMF . mo. CCw wT . fLoew.= EmSr = Te=m TTT . a88. 1389327 oc0oo0sms ooollesls awoe8oe oo0w0as% o0os3we% mDfo Bm--em3 213 NoTox Project 242933 nE-SIoNaDn--5259 AFATEMEARTO4LWOEGEYKSRECOVERY MGALRES5O(U PFEP HS) -------------- maoouet PeReTS am_ma--amr mmhe man w i w Fi wF=F mmam n mw oeoT;A a 7BBoegmesm e8sdag oe03amm smse3Ea ia1s3ess BBmEia mBB2iE 0885H0 -- maoroLoomane T aa_m--omw o18n5 w FT m 3Bo. = w w. om ES = =Fy nB B o aE dss 00g.o60s0s S0o.ol0sa8 00g.ll00a0ld0 0a0d00mm ooossaos shmeao 1bm0sss 214 NoToX Project 242033 AHFATEEMRATO4LWOEGEYKSRECOVERY G MALRES6O(U PFOPS) wewS-izon--3359 _-- `Boros ETS m oa_me--amn memman w I r fdmer r w=n mw in w w aame B $s 0 s aTm aowds oSeamumee mEmm bs iI12me6 #Bm3aE BBw7ia0 HBwAm -_-- maorouoopeneTES _mneo--mw. aoh iwmC I BC ao eI wP . t eenm EE = o=r 5$ 25 mW1i5s oo0lae0s oo0sel0so oooodokem co0o0os% aeolasems 1B1a32 nNH9aa3 215 NOTOX Project 242933 AHAFRTMEARTO4LWOEGEYKS RECOVERY FGERMOAULPE1S (VEHICLE CONTROL) | mew-35zvDan--3331 -_-- `moro ems _C emo--mw man ICE E T F = E TmaR n oeaFos nowo oeoranm a39da eoedmas mmsm3a IiusmeE 2BBFia BBmIda 83s5u2 -------------------------------------------------------- `mores PARNETIRS moaam _-- aane iFN C = C P i m = ==] =m mi wooos 8s oi0.oo0e0 o0Ol.lo0ep0xs0 0a00%90 oooooom oooassne Bdmeeo iMoiees 216 Notox Project 242933 AHFATREMRATO4LWOEGEYKSRECOVERY GFREOMUAPLES2 (TELOMERALCOHOL) WeM-FIvRD A- T3H3 -_-- soroiootmes _m nwme--es Wm m emm an wer Eniev r == m=an ow oeormAama FFmEesC ess sa oo04le0 w wmse s 1i3pm BBmEEs BBnlia o58m6 -_-- maaLorPes C Ma_ma--omr owehe T= T Bao. T ww. een ==7m = =wr mH wos ooae33 o0o0oo5n5 oo00al0dds 0a00o00e0 oboeoomms ooossoass 1BHya. aMd 217 NOTOX Project 242933 AHFATEEMRATO4LWOEGEYKSRECOVERY GFREOMUAPLES3 (TELOMERACRYLATE) HeM-3z5uaDr-- 3333 _-- Baro PETS : ma--o_om--r TmA emmar 3er CeEdr 7 w=e m mwien r w4w amaAen wiog wgseew a8a3s oe oiassBfSs dmIaEEs oBBmiFa mBB8si3 essmaa -_-- -- oa_P a--mr voens f=mI C3BC e F deo. tm = =E = C=a Miida 1973e3 0ogmwessm onooblwo o0o0oe0m 0oo0aasnd eoosmse mhm2gs. 11gedSe 218 NoTOX Project 242933 AHFATREMARTO4LWOEGEYKS RECOVERY FGERMOAUPLE4S (1) _-- mamoLoor PETS eamaowm TwAa m)an Iw A m Fi = md# os 8 2E2ks asalsa oSo4mm2 Hssse3ad 0 1ii2df6em maomoo PETES awmaon aon {=m m FiEB e oo0e0us8 oooooomm 7FE oC0.l0e0o0 oO000o0% nEw-SoIvaDr--335 mEinNE BaBm1Ys0 OmBE3s30 OO a Es n ao 56 ES ooseessws mWa3s0a0 =TT 1MM0Efg 219 NOTOX Projectv 242933 tT AHFATREMARTO4LWOEGEYKS RECOVERY GFREOMAULPE5S (FHS) 355arN-E3T3] orcs pws mmaoma wm m mmo an mir m Bmso omoomn 3aa2 oe9sa3er w Fd m = assaenoe iuoame3% mh in E Tona BdmaId BBonIi, a59 maoLos pes mamaoms owna [37 T. FE > ES =wo E n me H os . o 009000m66 ogSlo0ss0 oo0.oo0o0 0a000%0%i ooessaes mnBgse i31g2s 220 NoTox Project 242933 AHFATEEMRATO4LWOEGEYKS RECOVERY GFEMRALE6OS(U PFOPS) He-FzuoL-A36 FE -- macyPNET _ nTmoomws TwLa mye-- n Iw A eFd - Tw Bmo eme mimn F - 4ww A r aA s m fmoeo eemalaou7 o0osdmss ssdhe 11I33am8 mB33sm3 mBB83s30 u39e5%8 EE ri. i na_C o--mw o2n f=mT m7 o. P w w. teen = =EE = =or B51y m7Tao4 oogwoesms coolloassms a0o00e0 ooooosmm o0osmsee dBmago | 1Hmfe 221 NOTOX Project 242933 ACFLTIENIRCA4LWEBEIKOSCHEMISTRY LGREOUSP 1 (VEHICLE CONTROL) oz3-0z5uupam-953 Nmoeum _-- MuAaSlT) 1iPooesemm is FI esdam i s soe oms s 88 5 %eeHl uB0o0 e9k% AwSaCdOT wBeTld. EaE Nm d3a d3SamEm i3 aEdlmae 333 3iimEh. 333 r3E 33 mGeRiLnT. mTWmeE,iO | GwT eEnRDmsa ee mo22nn , 1 is ooeemmm a30sBB seseSa e83s miImeeo Zo. 1uoomlm Im x33 Se 8 85838s an 5s iiZman is w8 osm %o3R% od 3 $eg3nu 8883f es 98 ZE Taa E G sX 3 R aao ie i3333 maomw --_--_-- PaOnTENT. AaBN 31 : 4 oossss RmomEee s s msE=si mhdsil asos amys3 RkwriE n noooEw2s8 mkmaey M BEE E mmei -_-- mR-_Ea--Ew mGuiclT mGemimE 1i3oiz8se aamw 3 FI 38EEE55 78sig1 Eu &0I5w 5 FBI Es E + aI5g] uBo IEBE 355 GoOnSHEN Ne 2 NS oASall mmTRM eG 7m s msceA orln mmFeomeanstn B oBma O iG laa BE i 2as8 a23m:m Te da a1ea8sn3 aifm an On B Ro3n0i SIi8s d m3 13 oess9 TFFsmm es Ia 1dE8ys3 i{4Rn%F en Op RBEEdI i3idY RS id w7Ee: REaimmoo 7s Fm vaar3n ifno aad 08 mBRoD 1ORs 72 dIme sNese f4fa 222 NoTox Project 242933 ACLFITNEIRC4ALWEBEIKOSCHEMISTRY MGARLOEUSP 2 (TELOMER ALCOHOL) cuEH-mvEp H- 2 -_-- mAaDmL _-- AetSlG) wASNaGon wBIeTl. & mCelod u. mTvImeGi,OCT eEeNnTOT SGeon ees m2one2an,n B Bno oeonens x om dBonERes dm 332 3 a em am 3 o i1m omiohm oa32 aom ok x Teeiane 58edz se ad a#z0oooeosmws 3xaa% 133 3 ok dw 3 dohw boommm 3xx iTsa oooomon ok fx a8Sn. ax 8 37#0 doosae aiEEas. 333 $0 em dm 3 fHIeEoooososm xx Is fm 2 eh fs 88a31 S580 553 a oe 3 3 om ol RN is 2 -_-- _mAmao--mu oRnOTEL 7. 7ABRGN| GALOBIN CF AG MEO SALaE l emTeeoinrn70smmseeolodtn mmFoemn baaAsTar Bm00 oooo%sH3es 35 hRm5se0 ws EmmEso ma R11d1 id a 3 m3 ds nSgms4oo2E36m% ea Zs 81180139 0Oea8Bs gn of 2m2 osoHssee mmpEea mB3Ip iniiso 1d 3 8% Bs BIO Te0eh aZIsae ad8aa1lk oGifap sena Fae aaaddn of 33#0 sRBlsi &s RWm3ya0 B30 BdBysI iiidpd E743 wsTsNl BEamEmo ldaassn oOLmfE op ue ra as 6 #0 wi m0 827 03 al Bn ds --_-- -- WNeoma --omeu-- lnleoee wGeeeEdeEe e ----------------e B n0 F aE mFE ionm B a3 E0 % 3 a5s 5 iF 3 r. aEs oa5mm B F EoE e m $oEs dn dn 238 mw 223 NOTOX Project 242533 ACFLTIENIRC4ALWEBEIKOSCHEMISTRY GMRAOLEUSP 3 (TELOMER ACRYLATE) cmES-omannp l-s33 -_-- MNemaews _-- vAaIsdG| GAaGriO wBEEeT. -- B 03 eeeewm #0 va aaammmda dw 3 3#B00 esoEs an3iakm sa iw 3233 gg 8a oneoms 8 on iroamg ie 333 a& om iEcm 32 -_-- mGeOlO UdT.T mTed,l |TCmReW ErAeTRDeEaail eeRs mmoammn simoemoaomm oe nd om R3 e8S3n0 aiso 5 7d im mh os eou 033B fe om xn acA sE ]a33 ae 83 Dree oIoeomsm 33 hms 3 733a aa87 se 53 5feo oeosm 5oH asEs 0os _F RADa--omu anFROTEDN 7. A5BRGN| oGLrOBAEN AGRTe O WAaFrd mA Deoiiosmmseeaonlm mmFeoemblahsdtin 3B0 o0oHmBs1s0 soommeee EaRie313Iag # oomdse kBas B B1 i3 d ezsalh Fazmsm ad1aa0dn0 ai$imE; gs 30 dws Oh 3 4 MEs330 msBEEo RBm3iE0 BL B33 iiiii 4 s sTmmoo asddeme oses 33sm ddaaaesnd dd{aead aaa5n 3Si &&a omHnhs wae kEBSds mi HN5Ds mE 0iidi id ge eon am I imo 83 du addaaaysn den OOfffH 8B @ ws BL ks ii #8 a dae Im _-- Nm-_Ra-- Ew wGiifir mGeimn F 3 is020m8 aomm $y#0 0ooraresm aam a@FH E FI E W ]im 8& Errhgw aaaam # niew aamw 224 NOTOX Project 242033 ACLFITNEIRCA4LWEBEIKOSCHEMISTRYGaRrOeUsP 4 ( ongS-imaunpl-edo -_-- _wmoa--eus ADaTuGd ) wASa(rGdon wBAeIlTd. = mGeenir MmwOemGd,OGmw AeTnOm RGeoeA r eSohnRm . 2 08eogm ii2nd0 222 #0 es Im 3 mi1om8 iuoEss xX3N iE om i sa 1:a0 Ea1ly8 78 6 s 8#0 en8es% 3arsm 333 0 om an 3 oE 3s o eomm nX3N iE om ox TTsaaw 535%9 TE Es B B 5 oxsve a ow Em dow 333 3h. 3 iiammRoooomem 8@ Eo ool 3% aTsE8 6g6ai% 5 8 aa eom%o IiEa 33 i oH osok && o 8 a5 -_-- _wAam--su oEnOTENT. 5ASRGN|FGSFAOSS 80 @Hmsss WwmEao #momo3a S F0 m Rs EHE kmSssvSE+mmsiSR s # i s 8s 3Hf 3mkEi RBw7Is0 as8 @ 8soae3n Hi kdmssd m3 aBmIE BE & wr mi BI NG RTe b11i3a iidn1 1ni3id 1ii3id iidd VAi Eat nmTRh eS osemsoeeorlow|mRPoemAanstin TaLo3et EFzeam aa0ed8d OGeffe wTsmeho iIdmsmo diewnds 0oR%f gd6go 3Im6no 88ms0df iufn eesrg oeIimEo Teo 3H g1a8n3gruOinR 8s OB em 8 Wd iB ---------- ee eee -- -- MNmEoRu--e-- eGeleim--Gm--eaio-- n ------------------------ i2 $s Si2ms iaanwm 8#3% 8% 1a5dm FE8AI Is am aF$ R m iy d5a EH] 8& E FE w oa 225 NoTOX Project 242933 oES-zovapme- s5 ACFLTIENIRCA4LWEBEIKOSCHEMISTRY GMRALOEUSP 5 (PFEHS) ------------------------------------------------------ 1 mammomu AaStCiE) GAeSdOT --_--m wBIeLEdT. |T mGReLlEdST. mTaem ,d| mGeErNTETecmeorn 0om2 ee &&& 0oos%ke Fanmms 312 & op in i i nimooosekm ea oh %3om 3% p72e.68r0 7% 777s1 75 nB so 0omuo%a iximaE iii no oe im 3 eooBmm o0e%mm 33 oEoed x 7aaa83 &a5 71 58 B i Be e es s a ai18Ea 333 nook im 3 om 3 oeohhn 333 RE 7p3e63 pert 78o33s 53 BEwa aieN i3 oosn oeBh 3% en8 d5a _-- eN--a_mu-- oonrn 7 oAABD G5SI NG ROTGALaPh rr =mTeRn iGn70s=msceolartn mmRoea mtsaern &esmoH#E2 @ Wn hBmaia By fmmule Ri 1I1f03 13 weeaeo da3m6m ge ze 0aaasd 0Ga%H aed iE . 3 ae&e 3B30 Hmksui mEmLys 11i33d nog Rd RE 13 0 wseor dIEnWs Te de idwaEdn iS{E8h aes Of BaA oom#as5h 7 He mwR3id ome aBBSeE mae 1i0i33 id dSaiiss 8 dE 3nmdde1Al8Es Re aed isGEdF On s BaW i B Bs RmE LIa w7sa IimmaaElE ooRh _ NNoRu mC-- eulte mGee, ie ,-------- a&& Fo2rm6e adamn0 B 8@ EEEFN imaamm B n no Es ERE aadno nB a ooE EEEE aa5mm BoaEse aian 226 OTOX Project 202933 ACFLTIENIRC4ALWEBIEOKCSHEMISTRY GMARLOEUSP 6 (PFOS) cnE3-0m%uapR--s5 TNaomu KGAaTiIE) aASnGOn wMeIlTd. | mGeOlLdESI mTOeGl.d|CwAmaSO Geeers F&aER ookm iamet 113 @8& ovoeek rixees. 332 B BoE koh aaamae 333 58% ooosEsm 3iz%Ea. 233 s0 caoe ianmc i3 vs18os oooHen 0oBR ais3a imdamoooonsa a33 i5n3 2a5 ooewmh xoxx sei5ns GFIeesI ea om om Xo xpseot oosm 0odd 03B e3h -_-- amamu oon T 7. AanBO| SGARRE WG Mo C ALP TorG d os scot 8 8a somos HWmila 8s8 HB#TS1 3Rm3is &8@ BHoseFe wEBEniI 8 s $0 & ky 3B3 BBwsyi B 0 B #E BBD mRmsEs i1idf BmEysi I11n3d dBBuiiso 1aIddn #B#330318iiG B EI DIoq e gsma is3ae aa1a08d4 gi3aE0 daamsm aMdasEd TTTaieo iNamRm daaeewddn isg&E 3a3me3 dadaaesn e7n3 dEes aaEn eGekn 8a685s a77133 875a51 7f5x9d a5 vPomdasTn 54oh%x u3ismn 6G4Gp3 oa4nE% Sm Mnmaem. meelTt $ &a 38 F2om &8so rFoxEEE B & HFEks 5F$N0 xs ak B so EoEE mGeE i adomnm aaams aadnwn ad5n 227 NOTOX Project 242933 ACLFITNEIRC4ALWEBEIKOSCHEMISTRY GFERMOAULPES1 (VEHICLE CONTROL) cn3-3z4uk -937 -_-- Nm_ea--mn GAaNtGI GAaSrCdOT-- wBeAlTd. mGeRlLdSv TT mMO ieGlLd, |TCeRV eEAnROEGeoelrsf mSonn R . $B70 oooeswe riamsm 3 8 oe is 3 af2ed0o ooooRmn 03oxB fre psi 5s w8ea31 ey i wo FER r0oR8d Fams |8 im os Emo 3 o iimmo nooookm 5o8d Pao ood pe63d napeiid a3 se iies oooues I3xmkk 23 isos ik. iifsse ooohlm o35u% iE ow 8 a7pe%d 8a5:388 6 73 mio ooomm iIFm 33 WiMg o0o8m 0 $a5 ooiF -_-- TN_oa--um RanOTI 7. AomAaGN |CoGFEABASN AG ROeE LeF e`nv lg 08mseor s o 7 a ai n1 a EBmYze od mEmiEa BI Iiwifo in soImcmo ii2Esm aaweed mE Wn imo ai wais GBaeeEe #omm31y ii13 we 03 3s Eee a$domo iEdsmE MedeEln S00 3m uy wiwe oawdEs30 es RWaEes Ri m3BiSs wi ii1nn adamw iEaEse ihm daaamnne a @#0mo&ers 13 w B37 inii aaE iayE ddaly mvFomyn ssrn 43oss G4Uahf oo{ff6 3i{d6 oiuw -------------------------------------------------------- Tnmaemmw emieeeire mSmeee 3 52 S2ima ioamma iimno ai3se8 35 55% 52 iios id i3a8 FH53 F iin r.iiEy 553 mo aE 5 eee 228 woes respons 203973 oWpms- 9 cSFuErmTnvEteReasr4,`WsErEoRcSmmarsTRY CROUE 3 (TELOMER ALCOHOL) r---------------------------- yNmEOENe OmRIe EHD TSS TORREe aamreedns we HWH#oom &O8gM8se Wooig 2miO impoo:331 i7 iom ErmmE GoEfcE oom H no83# mr sR #0 Ioam oRmm oogaon2en fk on : #Bw#FAoo88Os885ggA Boo i1mgmoo::Eo1Ap amo: @fiEommfos:tsReeI oo8B4oAg 0omiifmkk jE cE 0 ix oaonu Booous do%oo7 migoos8e BB F di oo on nMmEew peeea Ee EAE en HnWHoowOgge& BHooooggfr mM omoHm1 omomou nme on1o@mu ED omom oimoEHgmoEmEIooriEws gp Em mmo3mmlrouoiinm Hn on BBBooooggOgesg FA BA oBomm oompporgoomopI ig iBepEI riIreeo mmdan nidRn @B#oo8Oo88:%F mBmo ooBopmr o3 O ppER E mogey MEntomigw ornare----remer---- S nmono SGoG = se onB2B ioosgg1I3 EW3o=odg gBBB BE ooozo EiioF n8o2u wBBBo ooormie 3ao3x 229 000230 NOTOX Project 242933 ACFLTIENIRC4ALWEBEIKOSCHEMISTRY GFREOMUALPES3 (TELOMER ACRYLATE) cHEE -rvpH- 3 _-- NWooum _-- NuAaTeGE AGaeton wBeLlTd.F Gmeoldlv emm,e |TCeRef AnTHDRma eecon mgBso enoenm 1zIsmh 233 moos iy 3 wifenmoooleosem om x im os YH spaead $5 BBmes em oooem FEiEEm 333 Be oom zE 3 iiimso 0oooXmm oF3wH a5sE8a fe om % 3 mB8s ooeosaad Moos iIzmsm}33 ng 3 iiimsd 0osh8a 8& ae on 8 &3380 sa @@ E oR] mo 8 33 amsouosw 80% 5a538 _-- wEoanEn 387s00 a55d0 a33:d85 a70d3 7560 _maF a--su oanme7. AaBDI | Goe ARIN NGRFD ACLaD n wmmn eoensl7smmsoeoerony|wRolmeaisdtal mmo eeaonadd 3ma3e ##om37a Itfe mmoo @eos uuds mfin iiid 1ddaee se 2ids8mm am a80s28d SaImRE dan 35 Lm mee se@@r8 mo &3 oHoumsse aE aaWniE ilciiof nd i ss3om0 FidaEm I a ES dE dGeasen udidmf aaasdd Godd Lmwse ooe3sl won 5 3m6s2 aoBoDw 111313 Es as 1 Iesmno aFauasd $m Es dedaanns SdiEaE EY 3 wo ks ed XE id we 3% en GS -_-- nmow -_-- GvoeriGvuo w gmooaore3s0 a3w m nme i on a3d FEI5] oom se Eaaad a356 Fosr iose a55 ig oaIa a533 230 wotox Project 242033 ACFLTIENRIC4ALWEBEIKOSCHEMISTRY FGERMOAULPES4 ( chE-3t3vapR-- 3159 _-- _Nemmo--u wAaorrd ) aAerdon wBAeIlTd.7 Gmeol iTmmiV cAh |wCmEef r mwaehEos mmmlenmn wwios soouaml os ziimhm Ih 33a 3 Fr HE iimm ooossw o88w i os 8 5a5.98 6hbe1ed 53 73 ; m B FEO e os aSE=zIgmFE 3 us is mi2me3e ooohem #85 ZZee ooms 88 F&5r 35 (x 0 wi i mmo oloosw TiEsah. 33 #i0B oe iy 3 iE im omf0m8 9 4 ie 08 8 a25%6 u58s55 3H5E9 3825 ew an 3 ms we 8 en ad _-- R m-- am e oh por_ aSy A yp-- twrayrn vmToelnlgnes-- mmseeclond mmRomean seron uwwes oooessi ws ay omBwoon ome ms woahn 8aiaf 4 wooar Ss #1 1see2os or 23am38o ae wddaaasn Gs{Eea aan i i mmBooowesad3 wWwise 3a#0dE IiIfnf m0 ony nS #1 i ydyoeeo ye iR ids68da5aen io{Ennh 33 aad iE Imo mm FeE el=ws moa omSwiEso de om+weeBE 1i1 1 93 assnno awaimEo smo 3% dddaadsss iOUEnh aedd odfd mo 83 we Wi 1 ae ih Wn in _-- mow -_-- Sv ucri e Gv ene w FiRv m 18 a0 5 miioss di8Ea 225 mF#0oooiiee a55 m mE yIE.i5g FO 0 i8 EH 231 NOTOX Project 242533 ACLFITNEIRCA4LWEBEIKOSCHEMISTRY GFREOMUAPLES5 (FHS) cuE3-5x-paR--5151 RNmAaEu AGeTeGn ) AGeKeO BwLeYldT. ig wgm esoomm ai1nmm 3a3 iwsooooomsm IFrmea 333 iFeO oegyA i+ IEm 3 mmeoooooseoe%s EI1mnao. 333 wmo ooase IEmmo 32 GmeOlLdD. TmeGl.d| CmRmEMECwoceons | soReExn ir1eas 0 o1sBmow Bn am o0oo sh n33 H rreEr ohos xn ou HIo0 oofnwm o@ouw tveg 0oBm 8i igesan 7237 SaE. 1788 nseosa 8a83f Tialmes a9es3 wh3 s5k3 WMmoaL waForen 7. aABRGN| oGLAORREN | AG MATEO ASLdE n m`oerenos msoery ifwegm dswnrs i ie &ose3ss w ig o:8831 mm#oooooatmsfs mimosoo&@sr EWmEss aB 3w0l 30Ioos oB suyd IEmWfain1ada Bommne:ss dBmsIy 1ai00a Hwoss3 awma3 uoidno wWns m ms 3ia 88380 Fd21Em6 adwasae o E ds a dn a33 ddaaddds o mFeoaokFsE deWesss BF$eam r3a%Ee adEessy I foe REan Edasn mFoemnssin 3da%em tiiena GIiile u33dmh %GE Mnmaomy mSuecire mGemiene wm is 1I 2am yaa5m5 iie aiasa8 a35m M FgO I iR s om an mmfeooooin1ss% aa5s mmooo i% aImm 232 AcFuFEnTuvREiLReEaS4t,WEsErKoScamISTRY Grove (F0S) - EoeeRsisRMaTTAreMenme MREDeE atSSE eE eSOTmetE E ScS aameeTe aT ms owln doin im 3 oofE moo} ge gw Fg ore 8 mm Od Faas) - ; nnn N mmmEa emotrnream om NAr S BL, BBees eSme mE m e E mes Bog BOB OB inom osm nMomn mGoiw gen 'B BwoooooImEmma2ogm Bo om 233 000234 noTox Project 242033 AFCLTIENRIC2AWL EBEIKOSCHREEMCIOSVTERRYY GMRAOLUEPS 1 (VEHICLE CONTROL) cnz3omnn-5313 _-- Mm_aae--wm wAarGd EMwaanuilon MwieG i -- e meim n v m mmaemvl,a |OeG f eEmdee einoene mmSm aBn , e 28sowimem 3Fas8Em 333 hM2s3oooog8w R8aB a s5m3 i77da RE _mmeo--mw oonrmAoS t R7 |GG oIAsN wa 22 008ms1mse mommiee B R ma Ei I10 --_-- eres. W-_e--m man aA B82 on3 2em amwom m sw to Waarn eeelsm m mmoerf slmesmseeeelrin eRmomn eer 3amm dauSus.s Gamf 0 234 HOTOX Project 242933 CALFITNEIRCA2LWBEIEOKCSHREEMCIOSVTERRYY MGARLOEUSP 2 (TELOMER ALCOHOL) chE-3I0-v1D0a-8-1505 _-- Ae_DOm--. AweTrGd 3x IeR mem -_-- Mwoalthen SwLeIlTd. 2damEE 333 Gmeeldev r mmiO edd, Tecf aememweehmene m w5m2n, 2es t a onoe 3 3 a2s3 ea7e _Nwoa--.s aERnOTEDNT.AoBtGAN |GSLAosN |MGMea WAeA vTmeeoeldlmesmmeerl mormaen n : #3x0 m#L3so Bmmyoe immEe 1i1dda TE70Xe80 E2as dadasA a4s3 _-- J _w--m mR SE 3# n3 M2m am aa 235 noTOX Project 242033 ACFLTIENIRC2ALWBEIEOKCSHREEMCIOSVTERRYY MGARLOEUSP 3 (TELOMER ACRYLATE) one-3z0u-pmaR--313s _-- MmF _me--em MaStGlR) AGSa(tGhon wBAeTl. mGeeldim s mmiedl, O |c eTrr = aoe al a wmEeamnm a@donsoam 23Ism% 333 f n 1 ox o1m ow 2asms 37ea -_-- Nm--ma_o--mu a@a RE _-- a&8 aOnTE 7.AoBrRGN| GoAown Aemao AVean sWEmees Bmh1Ea EmmCee iain E8eIm stsevremsmrsr t SER SE 32F8Ea a95m mwmoelndnmesmsmceeolrnreoRemn ian T 23m v aisESI e4+m4; 236 Horo sesgecs 202833 AfcFurTniEmeRcan3,`WsErEoRScuRmECiOsVTERRYY GROUP 4 ( ) fPr23 a EBEER OM RIP EID LBCTC RE ommeemmn oa nB8 OeosmfE& 3i38m 133 1ii3gx coEsmmpeoe aiam mooouo -- ee-- e -- mt -------------- eer wmmoopTsee aa Re ENB E BnBo OOEo83ERmm1om3mo4 oimr1m 3oimn B im OEwomma oenx [E-- oa =F s3EB im1i5x 2= 237 0 Norox project 202933 ACFLTIENRICA2LWEBEIKOSCRHEECMOIVSTERRY-Y MGALRES5O(UPFHPS) cur3on0n -- 317 -_-- Mm_mao--wm MAOSECTE d nnoeoe emm -_-- ASREiPoTon TBSIIFTT.WSREe iTeCnn OTEaD, zEImER 32 o 1mom oom wcSepf neeSwemenlEn me mlmnm 28 i1E 3k uensf _ m7 nmaOmL AOT NTABGGN | GOoEin Ae arevASepenn DmweeemsnmossSwrEelwRd wmEaeSmnEes n a#o0oo0Ee8D 0 mB#3eIORa#Sms1011O1W f siEe g1zge ii way: a4opo; -_-- I h_a--m mT ET n idoiaoddes owmm 238 000239 NOTOX Project 242933 AFCLTIENRICA2LWEBEIKOSCHREEMCIOSVTERRYY GMRAOLUEPS 6 (PFOS) cHE-3tnwp--5819 -_-- _F NNeOe--Lm aAGnE) AwaSrOd T BwIeLlETd. |GmOeLlEdTs A.TmIeLl,d|TCwap Memo= EeGrs mmBaeannn s$sooomosa 1iz8ge 323 mi2Eooeosomh o83w 2B5m 067a -_-- i _F ama--mn oonmen7A or SM |GoASNI WG MTN eASeat|s mwmweea mosesmoeeoltn =mmemn ees : $ $8m 3ss RmomYpe E F2s3 oni1an 63% ex Ia2EEm daadsss um 0% DE Soa m_--R me me 8 18I28m aiamm 239 NOTOX Project 242033 AFCLTIENRIC2AWL EBEIKOSCHREEMCIOSVTREYRY GFERMOAULPES1 (VEHICLE CONTROL) 3n-R3T3] _-- -- Nmeaewm aAAnG AwDaR_ rGdoT weldBIT. GmRelRd-- . mT eld |G Tcwan e, mom -- aeah emm E weaen n wmwes oooooomm IzExs 233 wi1m9oeoossns o3oum Gee3m TaeEr -_-- _mNa--mm gFnoren T.Aors7 e|Ga oeA BAnDY Aomeio aNarrn wi1eooeeedda mlmEye WmdEEe 1oise me1oo8 Tmmeoaedlmosmsmeeinln =omman este 3Z2ss a8wd3ad ouaHlm _-- ar m n-------------- _a--m Se man wF8oE ae wm BB 240 NOTOX Project 242933 ACFLTIENRIC2AWL EBEIKOSCHREEMCIOSVTERRYY FGREOMUAPLE2S (TELOMER ALCOHOL) CuSzoztan--3230 _-- _AE m--u E MATEAi on= BILET T.v |Gv REv EmiEv, o | mv l msy a welv CI wme emns wm wm ooomosem zi Ium d32 2mta8o 8 ooea %o8w s1e2hf6 68&a7 -_-- _NaDOm--L oOn TN 7. aBitOON |GSAORINGo M0 AWO laprn TDmoeW minmos Smmoeenilnm = smoemets wmmooooomd&ass damess mBEEes 1n1d0d egaor 2mh so E daEe sU8sE% -_-- em _We--m mn SA m ma os sas a25% 241 ooo: .t HOTOX Project 242933 ACFLTIENIRC2ALWEBEIKOSCHREEMCIOSVTERYRY GFREOMUAPLE3S (TELOMER ACRYLATE) cnz-3zu3o 0- i3335 _---- _Nmmeo--wm| OwaCtR AGSaaotonBwLelTd. & GmoewienrsFmmieCdl.d Oemoearnnw ea een rvmw5e m2n ,s 8wHm ooeonsH ai8mE 2i3 mmo msm um B8op eTmna ad73a - -_-- _NmDaO--mL EaRnOTIONT AoRnRON GoheenAe Waoa ASpats TBmoel ml ee wsmeeeelrm dd omamebtnen mmwoeo oo%@e3sr #mB3ss cwmosmia oiisf $ave3 ZI2nhm 1dA0nEa aidgEEe -_-- _MR--E melt mei m B os a ie d 18 a55m 242 worox project 201833 enzSunni-233 AcFFuTemEaiRtcsa2nWEBErKoScRmEmCaOsVTREYRY GROUP 4 ( ) _-- aRO meEe NEEGOcRIriPOen eEIiDTE T meOE m cmRaSoGpaC eSe aE ns Eom,E ol mBBooosoMss o1oxmmo33od im mmoooigom s8ok 1womo onoeBs -_-- mer amee aa Sem New AE E E Be mesR | mBoooa aorghopmm lBo oa Epo r m no1n moawmomii:Em oBwmrr oaioEm --- -- = m- e m=.ee PBFEoEEmC 243 000244 NoTox Project 242923 ACFLTIENIRC2ALWEBEIKOSCHREEMCIOSVTERYRY. GFREOMUAPLES5 (PFHS) enzE orn E - 33 -_-- _Wwe--amn aNAnTIdGPT AUSNaNeoOT BmIeLlE7d. |= GmLelEdE.TmMeO Gld|G e menE mieN eem rs e T w2en ,E mgwoo ooue0s8 Iu1skm 333 I Liae o0 0s3%@a Se1h2o 17181g -_-- _F mwaa--nn aon I7 AoBr AGLoasADi Aemw moAwparn mmmoA nesmes msmeeeerln =rmoen mbAs wmwoooea@s@bs #Mow337 WouwEse 61ods aIeee8 ii2mnp ddwaaadn 8 daEe -_-- A _ oem mR -- SE ,---- mFoI as ie a55w% 244 HOTOX Project 22933 ACFLTIENIRCA2LWEBEIKOSCHREEMCIOSVTREYRY G FEMRAL6EOS(U PFOPS) oE-3z5wapn-- 3254 _--_-- _WnEm--Re GAaEcGh m iws soowm AUo sen= BwIeTll. -- Gmoewin mmiO emi, | s mcee oaev oehnsa e wam amn a e IaaEEm 232 fi 2a0 mo0oBw a&8g w 6EmT a5 _--m---- -- aNmomu anTED 7.A5Be |GoGAOLND NG W-- --O--ASpan Hmoewlemoes msoearlrotmemsestieoene wimom5 5sossg WdoneEs HmBSi1 111d0 166 wa ii2E0h Eawarsd 8ainm ---- rT -- Rm----D--ERee EE eee m mwos isNaeSs a55m 245 000246 HOTOX Project 22933 ACFLTINEIRCA4WLBEIEOKCSHREEMCIOSVTERRYY G MALERS1O(VEUHICPLE CONTROL) cHE-3zowkpaz--325s _--_-- _ mHam-- wm dAaNGtASGGatihGowneldBAIT. | mGeolin. mmme.i BLBoooeooemkm 3a is%ms33 f2ma0 enaomm Gemmeahnnmeceeeeens = wemn 3ooFw T8 ssa &161 _-- Nw_a--D_z-- gPnOTENT,NaBN| GoLA ORY AG RAS NWpA TmweeAslmosmsmorenl = rmeemsleArat B LBa eai i: mmmL33 HN nee 88808s s eam8 oo3ahm WdweRes isaEs ------S--i--m--m--e--r------------------------------------ _oe--m mR SEE F BBoooE Eams. aomm1 246 HOTOX Project 242533 ACFLTIENRICA4WL EBEIKOSCHREEMCIOSVTERRYY MGARLOEUSP 2 (TELOMER ALCOHOL) cuEz3z0nTpaR--3256 _-- _ARme--omu AGaTiGl R#3 o0coeemn, -_-- AUSaeOT= BwIeTld.v GmEeLldSv Tmiel.d T |Gmelnbesna eea a m wSeBn n aziEye 233 1Fhtooodm oa 3% seeonf e6as3 _E me--= gE n an 7 TonrRV ert Sal mmmf r emeeld p mm--etn --h---- 3Romumeze mB73F0 omBaaSn 9oi3sn Seo1n5 ne2aE8 waEnse um 8 _---- ere W-_e--m man F RoE nogns ST 247 000248 NoTox Project 242933 ACLFITNEIRCA4LWEBEIKOSCHREEMCIOSVTREYRY GMRAOLEUSP 3 (TELOMER ACRYLATE) _--_-- cuz3o5r-nMA2R37-0 . _mWoe--wm AaAthG AGSGa(tGon weldBIT = Gmoeiln.F mmiemO i.GV mueemceos eaons w waannm ssasuas ii2mmE 323 im 1 oaeose A3oBn a 0To S62ar -_-- mD--OaL_--TmoOnTEDN 7.AoBn M | oGASI NG RAI ID AWarn Tmmoeh lndmsesmoen rla ereomn besr i @somHe%e: Bmms3i 2wrDOQo0ls m aemn isE2e8 deaanel ooiGmE -_-- _We--m mn men a@samn Ela mom ' 248 worn pregect 241033 cnmSzzi~a3a9 AFAcTuLnEEvRSear4W,EsErKoScRaEmeCzOsVTERRYY GROUP 4 ( ) ---------------- T EeIOeN OEP WD Ta IR ETTRRooyaong Boom,n a 8s8g85 1i: 733 m iim ooiommroz ami8m oaom -------------------------------- e E mn T Ee eEmme wORm we B EBERSR 8a EEmB3 OEBms OBBB3 onO1B3 O8m18ono igsm mMwms: ieEm r--[EE-------------------------- r ma 8aE 1ioean Bo=mw e m e---- 8 oom 248 000250 Wotan seogce 242933 AcfuFmrTveEriRea4n,WEsErRoScRaEmCaOsVTEeRyY GR5O(U PFEP S) S3--_ 0 mRer ENMGAOE MTT RNIDMrT eSR TEmNE oepmeS ns E om BB7oo omew o 1mm o f m m1booexom g0 mismm ou -_-- mE ew E oTEae Nemes BRaT FBemremm my nBBoooOmEoeEDOBomDEe DOBmB310 G 38 sIiDm iiiEmE mMme3s oeuuwe JE-- Ey sem B7Zooodise omooum 250 000251 NoTox project 242033 ACFLTIENRIC4ALWEBEIKOSCHREEMCIOSVTERRYY MGARLOEUSP 6 (PFOS) cnEz3z0H-Dma--3350 _-- AF_me--o.m AwaGeH AwDadtehon BwIeTl.l 5#someosms iIummm 332 _-- Gmoeiim n i meO i|T eCere= eeemrm e mSaBn oifsea 0oo3hmsm om 3% ss nu uu esae : wA--m_a--o on INT.AorGH| oGF ee NGRSAS7 Ea mHmof eFee s mseel erl mreoemhnan 8as 0 H%m7o7 mmBo33o oBEaTnr 1iiad aea8e dI2hms ei8sE3 aiGefR _-- ---- W_e--m man ST 000 8s8or82e8 aianns 251 000252 HoTox project 242933 ACFLTIENIRCA4LWEBEIKOSCHREEMCIOSVTERRYY GFREOMAULPES1 (VEHICLE CONTROL) che3z5i-pMaz--3351 _-- -- mNemoesm -- GAaTrOd-- R AGKe-- IdO Bw-- LeLlTd. -- |GmReOldU-- T.mmaea-- i, | Gew-- EneMldeDGeE-- eGeoeonne-- eGeEeA-- npe m Hwoe eom as I2iEmk 333 B2a2w8oooomomm us 6aP 5 E35 : mNOaLm _-- onTED3 AaRGH |GoALOWNLGRIINO NWaErn 7 TmeRVslpim csSmoerf l mroemls men m H1o eseeds Rmwd3a HBomdIa 681380 mI1ee4 E2M4 Eawesos Uoa8fa --P _ ec --m--,---- fo via mFwEC ooies ow 5% 252 000253 NoTox Project 242933 ACFLTIENRIC4ALWEBEIKOSCHREEMCIOSVTERRYY. GFERMOAULPES2 (TELOMER ALCOHOL) cHE-atnwp--3332 _--_--m ND--eO_eL--s wNAaTIdGR)AGaNe(dGOT wBIeLIlT. H ewos x oooe 3m 2a6 322 -_-- |GmRelDd.Tame,l | mCReramEemweeeenr= oeeern s i2g6 omo1wm o8w eenn5 5ae8r _mNOe--Lm oP h OAoT LrDGGE N- | GN oLAOBIT N M. G RFIo AUsper wmBoes 8oo@%oa E3m%i2 awu3ss i00d3g a1msmo -_-- SfEEEpeeeerzrran W_e--m men mA moBesooI32E6s aa53w mDmoinoglmsmsmoernl ermeamalr stter 323% Wdeaden iGaERx 253 000254 HOTOX Project 242933 ACFLTIENRIC4ALWEBEIKOSCHREEMCIOSTVREYRY GFREOMUAPLES3 (TELOMER ACRYLATE) cuE-3z5uapa--3333 -_-- _MMm--ea: WMaartlhen Abmeien SweIl LT | TmoeV ul.sd.Ommmiedl, w iWgw osoosoek 1nIknm 332 2m18oooosomm _-- cemaeenme= ceonee m a2m2n , ow88 m o en sa a e -- emems oOnTI_ N.MaBARGNG | o-- r o AGRn m SATWraRr mDmee een isnmsEsmevnlt -- msmoemE els fmoeoas8ss Mwmsrs ENxYm0 Nio?ge e 38o6e amI21s9 ddbaaEnr 3s8a -_-- STi W_e--m men SAT Fwro aeIsA 56 18 254 HoTox Project 24203 CALFITNEIRCA4LWEBEIKOSCHREEMCIOSVTERRYY FGERMOAULPES4 ( -_-- _Nmmeo--wm AGDeTt w mmooeooess -_ Ado atn= BweLlTd.v GmOeO iLn ATmmeVLi 2EmR 323 i2ws8m ooaohm _NwDaO--eL onTENT.AoMnINF | GoLAL OBIN AGMo Atweeal mBm0 0 eG@syF wBwoae Hw3Ess 0o03s3 m2n8e J e-_m-- mR SP 1iBm oo21m89 a5w a ex30e%0aR--3354 TmGoeh wnmm= e ea er m mBe eRn , 8a gsee 65e3a vmmieenn.dmosmsmoeerdeemoemn len i2Ih:m E0 GdE 3uogfm A 255 NoTox Project 242933 CALFITNEIRCA4LWEBEIKOSCHREEMCIOSVTERRYY FGERMOAULPES5 (pFES) cHE-Szavon-3353 --_-- _MmOe--Lm aAtNlGE NGaatin wBeIlTl.7 Gmoeiwnev r mmeO Gi. ocmei a ro mewaleeeee o mmlEnT mwmoo ooeooonm IaiRmm 323 1iE6Em8C oooen 33 a eERn. osse _-- _ 1 MF mmaem manore T.Momraow|Goonosny |AGmC rASsat emmeenA glmesmsmeeeaenlm mrRoemeeleid m mwoo es 3ed 3aHsE nsBsoS ne 0 JCLReBE z3aa 5 mdeessA a{w34 -_-- PT h_--m 2 . m wmo oaom 1d8 aa5 * 256 000257 NOTOX Project 202933 CALFITNEIRCA4LWEBEIKOSCHREEMCIOSVTERRYY FGERMOAULPES6 (PFS) cnE-3t5w-pmaz-3356 _-- _mwm--mm NaAcTdIGR AbTiaoconB-- mLeTld. |Gmoeilmd iTsmeV .l|TcmreN eniameeeean ee mwEimmn wmmoo osooms im 1snd}2 m i 238 o sn mom 36a TaoH5n a75.56 -_-- ma_o--mn oonrn 7. AAmeen mwomoowwwisd So#wH3s RE J W_e--m man SRT m w oi a ne e g oiWRw GCoChONE B6omDse A/GSmSaeNAwsal I1d1 iS3e5o memoenlslmom ssmeeel lrt ermoen mlan dE2mEm: BI0esEDo6Rn 257 NTEOLTOOVXERPrAoLeCcOtHOL2/42T9E3L3OMER ACRYLATE! IPFHSI-PFO.S MA2C5--TFNEDB.-991 MMAALCERSOSCOPIC FINDINGS. `GROUP 1 (VEHICLE CONTROL) an 1 No FIOM WTED wo 2 Ho FROIN WED ws Ho Fone rep oo i Mo FIOTIGS NOTED [ 0 FONG MTED wa 6 40 Fons NorED 7 0 FIROTIGS NOTED oa 8 #0 FOB NITED as SKN, GREST REGION: ALOPECIA. a 10 0 FIIOINGS NOTED rn 0 FODGS NOTED (SCHEDULED NECROPSY, 03-40V-98) (SCHEDULED NECROPSY, 03-40-98) (SCHEDULED NECROPSY, 03-01-98) (SCHEDULED NECROPSY, 03-M0V-98) (SCHEDULED NECROPSY, 04-h0V-98) (SHEDULED NECROPSY, 04-40V-98) (SCHEDULED NECROPSY, 04-MOV-98) (SCHEDULED NECRIPSY, 04-NOV-98) (SCHEDULED NECROPSY, 18.M0V-98) (SCHEDULED NECROPSY, 18-M0V-98) (SCHEDULED NECROPSY, 18-M0V-98) 258 000259 NTEOLTOOMXERProAjLeCcOtHO2L4/2T9E3LO3MER ACRYLATE/ MMAACLREOSSCOPIC FINDINGS `GROU1P (VEHICLE CONTROL) ou 13 No F1IaINGS Kore oa 16 No FIIOINGS NOTED a 15 Mo FOGS MoTED [PFHSI=PFoOS MAC2-5I-NFDEB-- 992 (SCHEDULED NECROPSY, 02.06.98) (SCHEDULED NECROPSY, 02-06C-98) (SCHEDULED NECROPSY, 02.06C-98) 259 000260 TNEOLTOOVXERPrAoLjeCcOtHOL2/4T2E9L3O3MER ACRYLATE! /PFHSI-PFOSo. MAC2-5I.NFEDB.-993 MMAACLREOSSCOPIC FINDINGS `GR2(OTELUOMPER ALCOHOL) a 17 Ho FINDINGS NOTED a 18 No FINDINGS NOTED aa 19 } No FIDINGS NOTED wa 20 NO FINDS NOTED ina 21 No FIIDIGS NOTED a 22 Ho FrIONGS NoTED a 23 Ho F1vomGS MTeD ; aa 24 No FINDS NoTED oa 25 . 0 FIO WTED a 26 Ho FONE Nore aa 27 TESTES.............. RENCED IN SIZE, FLAGCID. (SCHEDULED NECROPSY, 03-401-58) (SCHEDULED NECROPSY, 03.10V-98) (SCHEDULED NECROPSY, 03K0V-98) (SCHEDULED NECROPSY, 03-K0V-98) (SHEED NECROPSY, 04-MOV-98) (SCHEDULED NECROPSY, 04-4e-98) (SCHEDULED NECROPSY, 04-40N-98) (SCHEDILED NECROPSY, 4-4eV-98) (SCHEDULED NECROPSY, 18-M0V-98) (SCHEDILED NECROPSY, 10.M0V-98) (SCHEDULED NECROPSY, 18-M0V-98) 260 000261 NTEOLTOOMXERPAroLjCeOcHtOL2/4T2E9L3O3MER ACRYLATE/ MACROSCOPIC FINDINGS . MALES GR2O(TEULOMPER ALCOHOL) aL 28 No FINDINGS NOTED aL 30 No FLIDINGS NOTED aa 31 No FINDINGS NOTED /PFHS/pPFOsS MAC2-5I-NFDEB-- 994 (SCHEDULED NECROPSY, 02-DEC-98) (SCHEDULED NECROPSY, 02-DEC-98) (SCHEDULED NECROPSY, 02-0C-98) 261 0 00262 TNEOLTcOHXeRPrAoLjGeocrtol24/2T9E5L9OVER ACRYLATE! IPFHSIF. FOS Waer.es -ss5 MMGAALCRERSOS3OC(OTPEUILCOFMPIENRDAINCGRSYLATE) net 3 [ryT------ ow 30 to roenes tore a 35 To romes ware : ANIWAL 36 10 riones wre a 37 To riones ore ey Py------ ao 3 [Py---- wan a To ruonas wre ani To riones re wai 12 To ruones re a 0 To Fons ores (sane ers, 020-99) (sce ezorsy, arse) (sae vewrst, carov-38) (SCHEDULED NECROPSY, 03-NOV-98) (see ecwrst, oarov-s8) (scr wecorsy, oa-v-99) (see crs, 04-9) (sans eckest, ok-ov-) (sae ces, 10-04.) (seme recrsy, 100.90) (soe ecxesy, 1010758) 262 000263 TNEOLTOONXERP,roAjLeCcOtHOL2/4T29E3L3OVER ACRYLATE! /PFHSILPFOLS . WAC25T-NFOEB.-996 WMAACLREOSSCOPIC FINDINGS `GROUP 3 (TELOMER ACRYLATE) Me oIRseror----------t------ (SCHE-- DULED--NecRo-- psY,cr 0e2-0r65r-e98) 0 Fuomes ore nw 46 (SCHED NeckopsY, 02-06C-58) 10 Fos WE | Jos 47 (scrEuLED NecRoSY, 02.06.98) 0 roms Korea 263 00026: 4 NOTOX Project 242933 TELOMER ALCOHOL/TELOMER ACRYLATE. MMAACLREOSSCOPIC FINDINGS GROUPA( ) ai 0 F1I00GS TED a 50 0 Frames Kore aa st 0 Frames jor oo 52 0 rianes ore an 53 0 Fivoncs vor a 54 0 Frioncs Nore a 55 0 Fnionas ore na 36 a FriomGs wre a 57 w Frames ore 58 #0 FN00GS HoTED no 59 0 Frones tore FT IPFHS/PFOS we-1o - 7 25-FEB-99 (SCHEOLED ECROPSY, 03-0V-98) (sCEO0ED eROPSY, 03-0V-98) (scEuten recaps, css) (SHELED KECRPSY, 03-10-98) (SHEL NECROPSY, 04-01-50) (SHEED NECROPSY, 04-40-98) (SCHEDULED NECROPSY, 04-40%-98) (SEED NecRPSY, 04-40%-98) (SCHEDULED NECROPSY, 18-M0V-98) (SCHEDULED NECROPSY, 18.40%:98) (scree NECROPSY, 10-401-98) 264 000265 TNEOLTOOMXERPrAoLjCeOctHOL2/42T9E3L3OMER ACRYLATE /PFHS/-PFOS MACROSCOPIC FINDINGS GMARLOEUSPA( ) 61 EYES..........o..... RIGHT SIDE, LENS: REDUCEDINSIZE. ou 62 Ho FINDINGS NOTED oa 63 Ho FINDINGS NOTED. MAC2-5T-NFDEB-- 998 (SCHEDULED NECROPSY, 02-0C-98) (SCHEDULED NECROPSY, 02-0EC-58) (SCHEDULED NECROPSY, 02.0C.98) 000266 265 TNOETLOOXMERProAjLeCcOtHO2L4/2T9E3L3OMER ACRYLATE! /PFHS/= PFOS MAC2-5T-NFDEB-- 999 MACROSCOPIC FINDINGS GMARLOEUSP 5 (PFHS) -an. a 6s No FINDINGS NOTED (SCHEDULED NECROPSY, 03-N0V-98) oa 66 (SCHEDULED NECROPSY, 03-40V-98) LUNGS. cove HEORRHAGE STOMAGH............. GLAOULARMUCOSA: HOMRRHAGE. TESTES.............. REDUCED IN SIZE. EPIOIOMIOES. ... REDUCED IN SIZE. aa 67 (SCHEDULED NECROPSY, 03-40V-98) Ho FINDS NOTED. a 68 (SCHEDULED NECROPSY, 03-40V-98) 40 FIIOINGS NOTED pa 69 (SCHEDULED NECROPSY, 04-h0V-98) Yo FiOS ATED wn 70 (SCHEDULED NECROPSY, 04-40V-98) M0 FINDINGS NOTED J 71 (SCHEDULED NECROPSY, 04-M0V-98) 0 FINDINGS NOTED aa 72 (SCHEDULED NECROPSY, 04-N0Y-98) LIVER nn, BUARGED | aL 73 (SCHEDULED NECROPSY, 18M0V-98) N0 FIDINGS NOTED A 74 (SCHEDULED NECROPSY, 18-10-98) TESTES............. REDKED IN SIZE. 000267 266 TNEOLTOOMXERPrAojLeCcOtHOL2/42T9E3L3OMER ACRYLATE/ MACROSCOPIC FINDINGS MGARLOEUSP 5 (PFHS) oa 75 0 FINDINGS HoTED a 77 No FRIDINGS NoTED anc 78 No FINDINGS NOTED a 79 0 F1NODGS TED [PFHS/Lo PFOS MAC2-5I-NFDEB--9190 (SCHEDULED NECROPSY, 18-M0V-98) (SCHEDULED NECROPSY, 02-06C-58) (SCHEDULED NECROPSY, 02-06C-98) (SCHEDULED NECROPSY, 02-DEC-98) 000268 267 erAeon Teter AcovATe) [priors ween as I. `GROUP 6 (PFOS) o rroves wo om we ---- ro | ANIMAL 83 ow NO FINDINGS NOTED J oro owe 1s wr ness oro ` on ome ww mes on FO-------- oma rr, soon) (SCHEDULED NECROPSY, 03-NOV-98) oD, son ; rams an, won ons en, seven) (som rcs, o41009) eo vy, ern) Sons wy, soon FO ---------- ANIMAL 91 ro : (SCHEDULED NECROPSY, 18-NOV-98) -- 268 000269 TNEOLTOOMXERPrAojLeCcOtHOL2/42T9E3L3OMER ACRYLATE! MMAALCERSOSCOPIC FINDINGS `GROUP (FOS) wo 53 40 FivoDS wore Ja 5 Wo F1O1IGS NOTED wo 35 40 F1ioDGS NOTED /PFHS/-PFOSoo Wac2-51-NFDE_8--1929 (scHERLED NECROPSY, 02.08.90) (SCHEDULED NECROPSY, 02.06.98) (SEED tEcRPsY, 02.05.98) 269 000270 NTEOLTOOMXERProAjLeCcOtHOL2/4T2E93L3OVER ACRYLATE! /PFHS/.PFOS MFGAReCORUnOPSsCWOePHIiCoFLIENDCIoNnGTSROL) oe [Py---- ww 38 J ------ one [ry-- wo 0 wo -- wo Jop---- wow. 12 +o rioes vores : MAC2-5I-FNEDB.-9193 (soon ers, 050058) [EA -------- PI -------- FR -------- (sone vey, 0640098) (scene eon, 062019) i. ANIMAL 103 = ron vores wo. 14 ro J--_-- FN ------ an 106 fry-- won 17 ro (SCHEDULED NECROPSY, 06-NOV-98) PO---- J--_---- [I---- FT -------- 270 000271 TNEOLTOOMXERPrAoLdeCcOtHOL2/4T29E3L3OMER ACRYLATE/ /PFHSSIPoFOoS MAC2-5I-NFED8.-9194 FMEAMCARLOESSCOPIC FINDINGS `GROUP 1 (VEHICLE CONTROL) aL 109 No FINDINGS NOTED a 10 No FINDINGS NOTED a 111 : Ho FINDINGS NOTED (SCHEOULED NECROPSY, 04.0E5-98) (SCHEDULED NECROPSY, 04-0EC:98) (SCHEDULED NECROPSY, 04-DEC-98) 000272 271 TNRoOrioeRproAfLeCcOtHOL24T2E98L9OVER ACRYLATE! MFAECMRALOESSCOPIC FINDINGS wo 113 GROUP 2 (TELOMER ALCOHOL) [rp---- wo 114 o Foes ores 115 /PFiSIpFosoo W5e..18 5195 (see wees, 5.09) neu wecursr, c0r9) (sce ers, os.0.98) : NO FINDINGS NOTED a s16 1 rons tors 117 sec veces, 5-0) (scene crs, o60v8) } KIDNEYS............. RIGHT SIDE: PELVIC DILATION. 110 to renes tor os 119 [Py---- -- To Foams ores (soem wees os0n9) (scene curs, son) (sete crs, as0-58) ANDUAL 121 [Py---- (SCHEDULED NECROPSY, 20-NOV- 5 - ANAL 122 -- a 133 Jo Fioncs oreo (SCHEDULED NECROPSY, 20-NOV-98) (scenes secure, 2.0099) 000273 272 NTEOLTOOMXERPrAoLjCeOctHOL2/4T2E9L8O3MER ACRYLATE/ MFAECMRAOLSESCOPIC FINDINGS `GR2(OTELUOMPER ALCOHOL) a 128 No FINDINGS NOTED a 126 No FINDINGS NOTED wa 127 No FINDS NOTED [PFHS/SPFoOS. MAC2-5T.NFDEB.-9196 (SCHEDULED NECROPSY, 04-0EC-98) (SCHEDULED NECROPSY, 04-02-98) (SCHEDULED NECROPSY, 04-0EC-98) 000274 273 NTEOLTOOMXERPrAoLjCeOctHOL2/4T2E9L8O3MER ACRYLATE /PFHSILoPFOS w2e5.p78.1979 MFAECMRALOESSCOPIC FINDINGS `GROUP 3 (TELOMER ACRYLATE) ow 129 0 rans wore ow 130 0 noms wre ow ss 0 FROGS wore i ow 132 0 rIvomEs ore A 133 Yo Fon NOTED ow 134 0 Frans wore : a 135 0 Fane wre 1 oa 126 0 Fons wre ow 137 40 Fons tore oo 138 0 FoBIGS NOTED aL 135 Ya Fics ore (ones, o5.M0v-8) (SCHEDAED NECROPSY, 05-N0V-98) (SCHEDULED NECROPSY, 05-M0V-98) (SHEED NECROPSY, 05-40V-98) (SCHEDULED NECROPSY, 0610-98) (SCHEDULED NECROPSY, 06.40V-58) (SCHEDULED NECROPSY, 06-40V-98) (SCHEOULED NECROPSY, 05-MOV-98) (SHDIED HecRoPSY, 20-400-98) (SCHEDULED NECROPSY, 20-N0V-98) (SHED HeCROPSY, 20-40%:98) 274 000275 NOTOX Project 242933 TELOMER ALCOHOL/TELOMER ACRYLATE/ /PFHS/SoPFOS MA2C5-T-NFDEB--9198 MFAECMRALOESSCOPIC FINDINGS. GROUP 3 (TELOMER ACRYLATE) OAL 141 (SCHEDULED NECROPSY, 04-06C-98) No FINDINGS NOTED aL 142 (SCHEDULED NECROPSY, 04.DEC-98) NO FINOTNGS NOTED -- ANAL 143 _-- _ _ _(SC-- HEDULED NECROPSY, m 04-0EC-98) 0 FINDINGS NOTED. 000276 275 NTEOLTOOMXERPArLojCeOcHtOL2/4T2E9L3O3MER ACRYLATE/ /PFHNSr/PFOS MFEAMCARLOESSCOPIC FINDINGS GROUPS|) a 14s 0 Frcs ore on 14 0 Froncs ores a 147 0 Frans ore Loe 0 Fnionics Kore a1 0 Fae wore a 150 0 Frames wore J a 151 UTGRUS..........0. LEFT SIDE:CYST(S). a 152 0 Frans ore wo 159 0 Fons wre a 156 0 Frionas wre a 135 0 Frames wore 276 : WA5C--I7N8D.9-199 . (SCHEDLED NECROPSY, 05.10v-98) (SCEDAED NECROPSY, 05-10v-98) (SCHEDRED NECROPSY, 05.100-98) (SCHEDRED NecROPSY, 05.00v-98) (SCIEO0ED NECROPSY, 06-10Y-98) (SCEDUED NECROPSY, 06-01-98) (sciEoED NecRPSY, 06-01-98) (SCHEDULED NECROPSY, 06-40Y-98) (SOHEDLED NECROPSY, 20-M0Y-98) (saEonED Hecrosy, 20-40v-98) (SEED HecrorsY, 20-40%-58) 000277 NTEOLTOOMXERPrAoLjCeOcHtOL2/4T2E9L33OMER ACRYLATE/ MFGEARMCoARrLOEaSSC(OPIC FINDINGS von 137 10 Froues ores on 138 0 FivonKs rare ou 139 Jo runes ore /PFHS/PLFaOSn'g MA2C5-I-NFDEB--9290 (una cars, ob3EC-9) (sceDuLED ecRPSY, 04.0658) (sane crs, 04.0598) a7 000278 NOTOX Project 242933 TELOMER ALCOHOL/TELOMER ACRYLATE! /PFHSrIPeFOrS MAC2-5-IFNDEB.-9291 MFEAMCARLOESSCOPIC FINDINGS GROUP 5 (PFHS) ao 161 40 FINDINGS NOTED a 162 0 FINDINGS NOTED a 163 40 FINDINGS NOTED a 164 : 0 FINDINGS NOTED a 165 0 FINGINGS NOTED A 166 0 FHIGINGS NOTED AL 167 40 FRIOINGS NOTED ao 168 0 FHOINGS NOTED ona 165 Ho Fri0miGs NOTED aL 170 0 FINDINGS NOTED aa 171 0 FINOINGS NOTED (SCHEDULED NECROPSY, 05-40-98) (SCHEDULED NECROPSY, 05-4V-98) (SCHEDULED NECROPSY, 05-M0V-58) (SCHEDULED NECROPSY, 05-M0V-58) (SCHEDULED NECROPSY, 06-N0V-98) (SCHEDULED NECROPSY, 06-N0V-58) (SHEDULED IECROPSY, 06-40-98) (SCHEDULED ECROPSY, 06-10V-98) (SCHEDULED NECROPSY, 20-K0V-98) (SCHEOULED NECROPSY, 20-M0Y-98) (SCHEOULED NECROPSY, 20-M0Y-58) 000279 278 NTEOLTOOMXERProAjLeCcOtHO2L4/2T9E3L3OMER ACRYLATE! MFEAMCARLOESSCOPIC FINDINGS GROUP 5 (PFHS) AL 173 No FINDINGS NOTED mow 174 _ No FIOnGS NTE moa 175 Ho FINOINGS NOTED /PFHS-/PFOS MAC-TND 22 25-FEB-99 (SCHEDULED NECROPSY, 04-0EC-58) (SCHEDULED NECROPSY, 04-0EC-98) (SCHEDULED NECROPSY, 04.0EC-98) 000280 279 NOTOX Project 242933 TELOMER ALCOHOL/TELOMER ACRYLATE! MFEAMCARLOESSCOPIC FINDINGS `GROUP 6 (PFOS) wu 177 Ho F1RoDIGS NOTED ou 178 0 ones wre oa 179 Mo FHiones ore naa 180 0 Fones ore a sa 0 ones ore a 182 0 FonGs TED a 189 0 Fes oreo a 134 ; NO FINDINGS NOTED AL 185 10 FIvGS oreo aa 186 2 Fhiomgs ore oa 167 Fiones wore coPFHS/PFOS MAC-IND -23 25-FEB-99 (SCHEDULED NECROPSY, 05-Nov-58) (SCHED NeckopsY, 05-0v-98) (SHEED NECROPSY, 05-10-98) (SOULED HecROPSY, 05-40v-53) (SOEULED NECROPSY, o6-hov-98) (SCHEDULED NECROPSY, 06-MOV-58) (SEED NECROPSY, 06-Nov-98) (SCHEDULED NECROPSY, 06-MOV-98) (SCHEULED NECROPSY, 20-N0V-98) (SCHEDULED NECROPSY, 20-01-98) (scree Necropsy, 20-hov-58) 280 000281 TNEOLTOOMXERPrAoLjeCcOtHOL2/4T2E9L3O3MER ACRYLATE/ FMEAMCARLOESSCOPIC FINDINGS `GROUP 6 (PROS) D_--L 19 Yo FRonGs red a _-- 150 0 Fons red a --_ 191 0 FhomGs red /PFHSM /PFCOS MAC2-5I-NFEDB.-9294 (SCHEOED NecRorsY, 04-0e6-s58) C(rSCHEDeULED NeECROnPSY,so4-06e C.58) f(SeCHEeOLEDeNECRe OPSY,e0s406e-58) 281 000282 NOTOX Project 242933 AOFRTGEARN W4EWIEGEHKTSS (GRAM) MALES GROUP 1 (VEHICLE CONTROL) | ow3s0z5Mup -554 : . aEmD mow WAN me ve mms mews sme moms i F1I am i sm m Z1To3o ze nLaOewM oe awmome r21aa SE Dn oogoalmn 00m oopstas SE 23aBm 1m 7 aaom ZLTemo imo uavemee res wDwm3e oZ3rR%e SE IS go03en8 NG iMehaEee Su i iImY 12 i GROUP 2 (TELOMER ALCOHOL) NaDosr morW. mA maT uve mes mos sew ems FnI omom FB Z I a a #x388 ZZ1ao8 rLeee aa1sm3e8s anems a1y0m9m6 132HS3 weilee am G0fe0od8w doougis oom od 3s3a%s 3a efsosoo doamoname wn us y a3Eh WE dm ogooelnm oipEli Gos ods 3338 3% G_R--OUP 3 (TELOMER ACRYLATE) aADsOL OCW. EAD _-- EE LVR xmews aemwss sme ges 3 33ammom #E0I om m2rEa fe aonsmme osm deemmm a3al% gm 3M ooooRem Eocdenen a13mp7 gon ose am . 3 @BadmWw orZnemeo ta nireemmm aaa aSSdEE IaINE 38 Ih S0SoN0m oe Sfomany of w3dr%a If G_R--OUP 4 ( E-_--E ew mw me amo mes mss sew we aER am de F FI t a1Z9o6 Lmaesas Loom weedemd emo aI1ERs RE g0oo0osk goomwoes oes da s31apap 1d 3 # 80a 3a nHveeg rIammEmsDo Tso owes 3d8Eh5 TE dIRnHR Ia 0g000os8d 038 ioaEf SE 13i3aE IR 282 000283 Notox project 242933 AOFRTGEARN W4EWIEGEHKTSS (GRAM) MALES o3g0zukoan-e}3 G-- ROUP 5 -- (FES) ee-------- ADL wmorw. man mer LVR moms amas sme moms --_-- &g & moamm a 3% 2LZe0oo Leo l1o3snmm lie 6BG8EEs 2ID7ns BE 3H ooodofsn oooisdes s3UBRa Of fi n8[i ou nk ZIImoso Ze nraemmes vee imWawse aaInhh Be IE ScooeHm oo8aan aI3eB og ons 1% G_R--OUP 6 (PFOS) OO NaOmN KOC. EAN WW LVR moms was sme mmoms _-- aF8I am 3% &a IZLsoPoe ae Mlosmee ain mmmlmemoe i2i3amsl BE za Sooodows ooolasykm 2RaEam of fi 1B 8 FI a3ma & af nrLsEooooualm8ms Zo wees mBBiwiG IiahNR ans 15 fo0oe0gs% oiosEmt IiiERa Soe oR E 283 HOTOX Project 22933 AOFRTGEARN/B4OWDEYEKWSEIGHT RATIOS (%) MALES owS-ozTuiapnl-sd3 _GR--OUP 1 (VENICLE CONTROL) AwDaLs _-- m(oatwud. ma eer LVR coms demas sme rem P:PF owon im 0ooas6 on o0oadsms d2ammm oe 338 oo0eR%s ols oOoooEnn 0Mo1Rnm ooosans ook om of . H75 E maE 8 oooeea ok ooeddmn 03% d33GE. 3m Co0o8sa qa ooooeon 0ood3di%n ooonaa oar oa 0% _GR--OUP 2 (TELOMER ALCOHOL) Mo ark wa me mm mes wows mew mms _-- nBp o omm3 Bom 0eofe8 oe 0oo3sdmme 3adumEs 03s 3h ooomnm 0% ogcfdoths ooolmay o0bs%as ooh eam bg 3 BFI oa de ER oeoefs oooseI I3dBmE oe ome 350 oo0nha 08 oogoaank oooudln oobmnE IE MR 0B G-_R--OUP 3 (TELOMER ACRYLATE) ea-_Tm-- (Ga I -- 3FE).om yFoI 8ooef oofa 0aod3de0ms oa% 3daeams dm 0oofs om ooOnoMsm Gow ooodIaa oiomng ods og ows 3 BFFI Io.m ooekeao aoodndeda 332%am ToonEm of oagooyhl oofddisel ooomdd Sow ods a -G_ROUP 4 ( Fa-_--Te S (Gn E Ep --, 822 aaam gm oc08le7 [ES ooouses 2d3eHs RE oo0:mm ooofomfhe oSoEsbB St 5c J 1bexYa04 $ 8 Boa am 0 ooofea om oosmmde ode 333smB am o0o0%am% SsOheXin oofdunsn eboeen eas fa hE 284 Noro project 242933 ofpmH- 4 A'MOFARTLGEEASRN/4BOWDEYEWKESIGHT RATIOS (%) G--R_O--UR 5 (FES) EE _--oER wore me mw um &a & Bmgmmo soewkn ge sswagem aLEFmB ow of B 28 0fHdm 40 p8ehe sa hwemmm d$fd8h me ih i wes oews maw mem ddomRm on p otommm pm oummeo eoomnm ro OIGFRn MR umfeemy sooanaw SN ug noomme om i _GR--OUP 6 (PFOS) : Momaaeexfoor rw at n me ar tn mes wows mem mms ------------ 8a a0u8m om dx0og8e aoooddmls yaIoeeSe oootamnmouoopommpn osdiiggEs oaoomamn B #80 d3B O%B SEesrRsE ModEdu nh 3wd MBRm f2OdRE tSSaeepnn mo oa olme nm oooeww om 285 000286 NOTOX Project 242933 AOFRTGEARN W4EIWGEHETKSS (GRAM) FEMALES _GR--OUP 1 (VEHICLE CONTROL) AaDOmC ow. EAN WNT --_--_-- n5$aami ILnassos oo0m8me6 F FA d2a ILLssee ooomsseo FwE aa Iiems oosses ou3-0z-uMApR"-s35 LVR KD oemoos sme om eeess3d3d 134 TegamEe 1U134E% s7aams 1iA 0eo.oo00ms0 08od%as o00.09m6 00000%ms oooddmse oooiuddi o0a% uodme iogmo ii G_R--OUP 2 (TELOMER ALCOHOL) [--_--S_--E mm uo sa aome fFnero oBaE f FE am Er ---- L2Lo0st3 Zee ooosmmme aaenms omy 7s l11s%g @ Oo0b0oa%m oooasstn ooodaaa oom oa od rLnesEs Te ooomnse seesmm oes Am Llisdsm Im 0oo0oommk oooadwans ooodouadn 006 oun oa G-R_--OUP 3 (TELOMER ACRYLATE) NmDeOmL mOYW. BAN MN LVR -_-- m F mo a rw .1% --LLese oo-mws sogowa B B nos i m ImIsmmsooo ooemmses @e3sf n ne swi r1e%s oosmwe velees KIONNS AMBOUS SEEM ONES ee ll--es =o0o0ms --ceaxew o--oaun 1IUSSs 0ood8dek ooowudss ooeammm lLlGa oooakm oou4se aaueg GROUP 4 (1) NoDOaL OYW. EAN Fuir sG 1a:m 1TFC8eS ie moe adfse 2LL0se0ee m#o0 aooe LTeess NC LVI ooS ombeelTE seam goommemsr aSe0mn oommse eemm KDW ANDO SHO OVARIES SnLEs&SN oosf L0As3ym oCond ULLs@a 00o49o%m8 oocsaaenm ooouumlse 1IH8 o98o0 oomm oomdes 286 000287 NoToX Project 242933 AOFRTGEARN W4EWIEGEHKTSS (GRAM) . FEMALES ow3-m0up5T-mo 6 G_R--OUP 5 (FES) wNDaOzL OCW. EAN EDR UVR Gms Amos smem om --_-- ww im omaImn imam 7 Inlp oeommIe essnem om gm i1iGe% dE 0co0aoasm oooswsms oooaasn 008 oun oa 6iw e i2is0 we LLTeme Tes gooesmmoe gTSleeae om aes 1li4dose ia go0o0na6 o0o3usa ooouannn oes oan od _GR--OUP 6 (FOS) ae ET _-- m mmo oims1s8 wo i 1ra8m6 Te opomeeee aemoam een aie iileal Ld ooolooogmwy cha m wi ia min wo dw r LLaeoeomoessms evTaee Teo orm ene LL1gG% im 00o00hs% Gey -- o0oaddm ooouuann ooodmda oooaamtn ooiii oodHs 287 000288 NOTOX Project 242923 AOFRTGEARN/B4OWDEYEWKESIGHT RATIOS (%) FEMALES oHu-mnEp H- 3 G-_ROUP 1 (VEHICLE CONTROL) Nm-D_a--OmL (xGoraw. aN MMW LVR EFIH ao FI oE oms E oordEEYdma ose ode 3M oii fn Waam no ooomms om oooddeee Hades os 3 KmOYS Ames Sma ozs 00 ooomda oa ooofogls 0ooaadk oo0a0an8 ofS oh oem 0o0%Hd ooOooEn ooMamBn ooSeeEmm GROUP 2 (TELOMER ALCOHOL) } -- maomr m(oarw_ . mm -- maT -- uvR ko-- ms mw-- sme -- ome _-- m Fiersoonas He om 0oesm% oss o0odde%ss y3ImaW om 3 ooommm 0 oeomno eRoaRam o0b0es8n oom ean ben Fff r e o oom o[gRsCoeI oe ooC oddmeesRE E 33 mooA 0m% Goooffd 3RopR= ME boss 0508 G-R_--OUP 3 (TELOMER ACRYLATE) N_fDa--om amowrw. mm maT Lv Koes mms sem owes HB2ooonaie0 nr one Iw-meo eo So--hmee ohn ITImLm Pooema Ia OE oo--mfep Goh oo--iSs oR--nR oan bon mB Bosm ams om ooeasem os ooolmes YI3aEH om 3 ooommm OB GoGoebll ooodRde ooSooR Gai oan sed G-R_--OUP 4 ( : T_e--am I owe i-- oiv smw8m i 0oosss 03 ooolanansy our 3aIra3 Yor ooommS om cSoooownn ooodmme: pooeoewn oon oan oe m iw niam wo eoosmoi os ooosee l3Ie%H ohs IE 0 oome GE oooooonnn ooodmmne: oooooemnm aon oan ook 288 NOTOX Profect 242933 OARFGTAENR/B4OWDEYEWKESIGHT RATIOS (%) FRaALES o3u65n s+ 88 G-R_O-- UP 5 (PFES) Nm_Daomu (mGoraw. EAN mw LVR Koew aeows sme oes w ig moIm Wm oLSeome oe oeowasnmo de3E3n 9oomh6 od 3E 0 oF OoeoaGrs oooddmes ooosooem on oI oe iiiesg aise FE. ooTonsl om doohldese d3EE0 ol 3b ooonnm on oo0oo% Sem ooeamns oi oogeoom 588 GROUP 6 (FOS) E MeDmL oGcanx wn mw uvS coms meas sm o--mems _-- m iFm a Es .18 0oeo8o o0oen3s 3 3aHm oomm OO eoofs pomm ooeums mmmooooss1 moo LLoome ocolddaees GgaaEE o0Gm:E om ooooodnke eoomdmae goSeesBst oR ond oon Leo oko Wm od gow om ole fa. Teo ole EE oa ah oR 0 285 NoTox Project 242933 AOFRGTAENRW2EWIEGEHKTSS RE(GCROAVME) RY MALES G _-- R1O(VEUHICPLE CONTROL) No-m_--aau worw. mA mewT FB ICm T a2D0a3 1oT3im8ee G_RO--UP 2(TELOMERALCOHOL) Noa morw. mM me _-- 3BEI oaass L Lees em dIemw GR_O--UP 3 (TELOMERACRYLATE) eMDsL worw. EAN mmr -_-- aa8 umomnm F oneeo ElamaIsm _G--RO4UP( Ao-_D--mL ow. 53 83%as EAN wer za 2e3 os aammes -G_-- R5O(U PFEPS) -A a_--m O orW.L EAN mer nnBoomHde Z2Fe0Ce0I 1s am on3eazkuaonT-s39 LVR mms aes sme eres a8rssa miaEmm oNoEof MoiEue I1zEe LVR xmevs amws seme eres aesEme AIanno o9oodin NoE sEm Ez1e8 LR cows meas sew mms eoemm IEG of bSEE biiE Lm mes aes sme mms LnNiaes I32R%s 0ca8os8ne oMNmRE 33aBBm LVR goes amma sme LsB aise w228sJ oc5oecsSENoJaEn mss i3+aa 290 NOTOX Profect 242933 AOFRTGEARN W2EWIEGEHTKSS R(EGCROAVM)ERY LES G_-- R6O(U PFOPS) ND mor. mm ENT _-- a % mam 22D00o9 1av3ba8en N3E5 MTaz-]35 LVR noms amsme n s memes d1c3a0 2o6S OOO 0c3o6u oomE s1aB WEIR GR UE EE 000292 291 NOTOX Project 242933 AOFRTGEARN/B2OWDEYEKWSEIRGEHCTOVREARTYIOS (%) MALES G-_R--OUP 1 (VEHICLE CONTROL) _ NaDeBs-- olrwy. man mar LVR #s00om8o o80Em poodeN R2aaGE owSosman--3431 Kms aoows sem mews o8SwBR fMoaiEn fMouEm ooomps G-_R--OUP 2 (TELOMER ALCOHOL) ma_m--om: wxogcy. mam mmr ive coms ews mew mms 3@50mB om eyeagm a SoeEm ap2n8s ofofde hoMEmm of omuesomoomm G-- ROUP 3ee(TELOMER -- ACRYLATE) ---- E foeelr-------- ---- -- 4@8 oB amm ERedmm eooalSxs 3aam odempR odNeEMs 0tE amm eoamm GROUeP 4e( c E amc Eec wEE msBoo0em3 eeem@m 0 eoolmR aiImEE ooomfa eee| -- -- oSSoEEo MMouREn o88s%%s Ge mROeUP 5 (pEES) e . AaDmL m(owrwd. mM ENT Lv cos ows eum ems X Amoamom ewemed esemsmsl aaasE oodisE odGomin cuSaEemU oo8sms 292 oTOX Project 242933 AFORTGEARN/2BWODEYEKWSEIRGEHCTOVREARTYIOS (%) MALES ow=6aNwapn-- 5133 G--_--R6O(U PFOPS) . Nwoaoz: --_-- E(oGrwNe. mT LVR mov aemws smn mem 32 a maamm ooos@s eoommmee 33 a%s eooRsm Soshoasw o0fafim 8 o0m% . 293 000294 HoTox Project 242933 AOFRTGEARN W2EWIEGEHTKSS R(EGCROAVM)ERY FEMALES umS5ntas--5133 GR-_O--UP 1 (VEHICLECONTROL) NaDm EOC. BAN NC LVR Ko Aeews mew oes _ wes amaw -- Laoos oo-- see essos -- 1ImA 0o-- 0fm oouul -- ooues wm Tes ols es 1B oon om ons GR-_O--UP 2(TELOMERALCOHOL) a -- : _-- m #ooamoa LrReessoomoosssus Tegmmd lLuaeso ooolewym ogEwmm ooouHas: G-R_--OUP 3(TELOMERACRYLATE) amomr morwmA. mM LVR komen omnis smem onus _---- + w HB s ow wi LrTseae ocoehbme 7iso0ee A1rwWm oo0ot0meg ooosddsa oooiaRsn G-_R-- O4UP(. ) Da_omu worw. mM mw LVR Koes manos sme oma BEm eR mon IT1ss8es ooosdsme 71reds CNIolGe boombess oeodudsm oo0dd3es GR5O.(UFHPS) raarn E ---- w fBe oawsam LrLoms ooosmbee gedmmm LnLsEs Go0oe8md% 2S03w38ea 0ocaa4e 294 HOTOX Project 242933 AOFRTGEARN W2EWIEGEHKTSS (RGERCAOMV)ERY FEMALES ou3s0zpA--3154 G_-- R6O(U PFOPS) NDOL OYW. EAN mar LVR onavs amos sme ones _-- wiFmse C.aim Z2Fae0 0eommmas Taewamos iuTdEe 0oo0oemkm 30f3a89m oo0nae 295 000296 HoTOX Project 242933 AOFRGTAENR/B2OWDEYEWKESIRGEHCTORVAETRIYOS (%) FEMALES _G--R1O(VU EHIP CLE CONTROL) Na_D--Am. B(OoCwW. EAN HAT LVI io[eo IEam e1 ose 0oedd4en0 a 33:a ow=3z0w-pwan--3155 KDNYS AREWIS SHE ommss 8 GosE ooobomsm og0adaoasr oo0.oo0nk6 G_RO--UP 2 (TELOMERALCOHOL) Nm--Dao_mL --m(moGwtem. --EAN MENT LV Kmavs Amos smmm ommss m wm o aE ma ooOmsB oopud8se6t 33al3Ms6e oo0ws% ooooowmn oooauddss oo0l.le0enm G_RO--UP 3(TELOMERACRYLATE) Nw_Do--Im m(OGYaWn. EAN NER LV w nBes omis o0T8es7n 0oe4wamsm 3Ydomao KDGYS anmwis smem omnis oo0mTm ooalofamnks o0aa3ia0n 0oble0esss G_--RO4UP( fa--ee_-- E (awm R ET -- i im m E B mde ooo8ms8 o0oud3se 3s33s%9 Oo07oa0 oG0o0slm oooaaunns o0o.l0dems G -_-- R5O(U PFEPS) Nw-D_mO--L m(oGar). EAN MAT LVR KD Aeews SEEN oss w mmoo miImm 8 oosm gooadmme a33sam oooeRl Gooooknm oooasaaes 0bdo.os5ss . 296 000297 Notox Project 242033 AOFRTGAENR/B2OWDEYEWKESIRGEHCTOVRAETRIYOS (%) FEMALES ou3s5taz-- 3156 - GR6O(UP-- FOPS) _-------- mMaDmL d(oacwx man mW LVR men ueas see ons _ F i 1m C.19 Ta1o0o oo03ans E ygams ao0R3 aOoooEnm i90aaBmm o0o8om%m 297 000298 worox protect 24293) AOFRGTAENR W4EWIEGEHKTSS RE(GCROAVME)RY MALES ouSszonan--137 G -- R1O(V-- EUHICPLE CrOeN-- tTeRe OL)ee es---- Mow mow EAN NT UR Goes cows sme mms e BHooom@ norw ee nme aEmee wBaF 2Ie R8 ooe e sg oowas zzaaeee #08 mm ns 8% Mg Ep G-R_O--UP 2 (TELOMERALCOHOL) i Ma-m_--omn mow. mor mae ve mes cmws sum mms ! i BB BooWwE 2iImma HpbaEEw se WE 23R38Q csNoeEw otwas a2imm G--R_O--UP 3(TELOMERACRYLATE) Mma: more. EAN ewe uvR mmo amees smem mms r $ @a mm ow mm e ziom lmMmyE m waBwsm 2R#sE8 e sMceoEemmee SosseRetm ad3eewBse _G--RO4UE () Emon mow. man mw wvm mmes moos mew mes cog8a &0aeEe 2Iamnm 1bngme aewdem 1ai3mE doMomMm eoMem8m nsiax s GeR-- e5Oe-- (UPFEP-- S) s-- t ------------------------, e Ma oan woe rw. mas me ----u--v--m ----c--om--es----m--e--ws----sm--e----m--m--s---- mnBooOmmE aIIEm RR EaEs soImdR I1a8nB oa ioEm ooiemms a1m3 298 NoTOX Project 242933 AOFRTGEARN W4EWIEGEHKTSS R(EGCROAMV)ERY MALES ow=3z0u-pwan--315a G_-- R6O(U PFOPS) Ni_Da--Am motu. BN WNC LVR Kms ows sm ess n s5i mom 2i1s9%o6 L0l9amms nasleae 2I2Ea3 ooSsoGsm oodsamsy 33L6ae 000300 299 NoTox Project 242933 OARFGTAENR/B4OWDEYEWKESIRGEHCTORVAETRIYOS (%) MALES GR_O--UP 1 (VEHICLE CONTROL) Am_Na--DOmU m(oGwn. AN WT UVR BnB oo oaas oLosGso oa0ma3e 2dx3ee6 GR_O--UP 2(TELOMERALCOHOL) _Nao--mu m(oowwe. man mr Lv 3B BoBEam eeoems oo03da%sm aEXsSes ous3z5u5pan--5139 . . Des Amos sem mms ooofgs ooaoofms osoammm oo0sg% coew ammacs sem meme GooE&m cgcoahss eoaaumnsr eLoawm GR_O--UP 3 (TELOMERACRYLATE) N_Boe--oan mooar mA ewe UVR s & moam oeomHs 0oemd3en aIammEo ooew aesos swe ems 00 oooeeh oOaGomRnE oigaanns 0oo%fm GR_O--UP 4 ( Nm--ma_osu-- (mGoraw. mA wer uv cbevs amoous sem mmm i Laa I.aa o9os%es oeodasu zaImmao ooonss oGMmfE Ho0Ea o0omBn GR5O(pUFEHPS) . i amomr Rm(oAaw. DmoA we uveaoeseatomem cs ememStmoims -_-- 7n nam mm co0sa% ea0a3wm0 iczdgge o0osBfm ooaaoHdn oiswdEsk ooosns 300 NoTox project 242933 AORFGTAENR/B4OWDEYEWKESIRGEHCTOVREARTYIOS (%) MALES G_--R6O(UPFOPS) mraoeum --_-- O(GCaHn. AN ENT LVR s5is am3om e ooss890o3d3es 3a2Mhm ow3-0z-pan--5250 Kmors anews Sum ooomxm oooosfm. i8osm3s ems 00 o1 3m% 000302 301 NoTOX Project 202933 OAFRTGEARNW4EWIEGHETKSSR(EGCROAVM)ERY FEMALES omSzmuapaR2-315 G_-- R1O(VEUHICPLE CONTROL) Amol morw. mm ww vm Koen cows sem ome _-- mm0oo9o aam a1r8oe6 oolselem Tgsohs 1I13a6% oooooemns . ooowufs oooaden G_RO--UP 2 (TELOMERALCOHOL) Na-_Da mor. mA WR Lv Kmavs aeows smn owes w Eworo ow 2LT0ee0 oConnodmm T1gRmm 1Ibs@R oe oosme88o03aim oooaaann G-R_O--UP 3 (TELOMERACRYLATE) -NTa_Dam morw. mM ww LVR i8 wam mamlm ILssosoooossms gTemee G_RO--UP 4 ( E am E -_-- m [m A oB a 2 nves 0eammsss geSomws _G--R5O(U pFEPS) oa mmEHooms3 t8noaso EE oooosmms feEmsm Kms emws sme om L3lae ooGooenem ooodwdisn osSuEifE -- r11gSa oeologam ooosafs iosBs -- EN ---- ID1EHs o0of8sE 8003a3hm io0a3Bn% 302 NoTOX Project 242923 AOFRTGEARN W4EWIEGEHKTSS RE(GCROAVM)ERY FEMALES o3p0-ua--3253 G_--R6O(U PFOPS) OO JaTsLe morw. mA _-- MER UVR Kom aeeois sme ves ww1mm fa3em mL Lem os ooemse oT1nems iU1@Rs 08o80o i0ouEds Sooinal 303 000304 NOTOX Project 202933 AOFRTGEARN/4BOWDEYEKWSEIRGEHCTOVREARTIYOS (%) FEMALES GROUP 1 (VEHICLE CONTROL) aMDmD mfoaw mM mM LVR HH w e Om E3 oo0mn8 w0elsMm aa2m3mo5 GROUP 2 (TELOMER ALCOHOL) aAmm m(Gyn WN mw om m FuEW m) oo0ms% oCow0ne3 3Iam%m ous3z0u5p0ak--5333 coms esas mmm ome 30oF%8 oo00Rim Mpznam oocoowme come wees sem ons GooEmm gI0o0Ens SMoAmuR ovoeeomsm GROUP 3 (TELOMER ACRYLATE) mA am M(GNa Em mw ov omens cmos mm omens 6 w ia om m#3 oo0srme ooSddeMes N2aaGss GooEmg ooopoerm opSmah oooooumn GROUP 4 ( . ) hNapm o(rewa EN me uvR omew amows mem oma . m m im oomma SoersZ ooommae 2NyEm%B oeommw. o0oo8fm Mp0aEmm sLoooomm GROUP 5 (PES) : NmaRe s(Gwa mm uve ones mes sew ome mm m s oo a3 sSomB oo0lmse adame1 oo0Eme o0 oofm pS0aaEmm goouoos 304 woven seasest 242933 oEnida ROFERrGTaAENgR/e4s0WDYEwEESTGSEeTRcAoTnIOS (3) GRour (pros) = E omy E EE -- BBmOooBEm emOwW ouOsMmE iomm osinm i oemm osau mm ssomm 305 ob 0306 RECENTER CPT ei RIEAY 16 ZV: 1S ProPath Gmbh APPENDI1X > Notox StyEnosucnh . =) Pathology Report Exploratory 28-Day Oral Toxicity Study with ~ Telomer Alcohol, Telomer Acrylate, PFOS (positive control) . PFHS and by Daily Gavage in the Rat followedby a 14126-Day Recovery Period NOTOX Project 242933 NOT3OMXTSesutbsntoa,nTc-e7s0E2334,874-,062344,53T,-78032520,21,78043425,6aTn6d28545141 `This report contains 146 pages FrmSamnwaisas h Son wAatE etemE ouo 000307 PATHOLOGY REPORT Page 2/148 TTSeepssottnsAoSrrytsitcelme::+ 3TEEMxLpOTlEooRxrAiactLooClroyOgHy26SO-eLDr/avyiTAcHGReaLYsvIOaAgGTeER/Study/PRiinS/eRraosts NPOrToOpKathno.no.: Date. : 29452091303 21.apr.1sss _-- TaofbCol ntee nts Table OfGOMLEBES .veeutteennestterteeeetneensateansteteaeiestantesteartest2 AUERERELCAELON111 u theateer aesuses eees3 MaterialsandBEEhOdS ....eeviiueutte tiettaeatteisseuaesetaeisatiateest4 Tnctiabdle-emAnCKOcSCOePLC ARALAGS +.rrstinsiuesreseenteenneeeieeeraee4s Tacidence table - selected microscopic findings With grades ..........eerseress. 4 Inctiabdle-eBLnCIOcSCOePLC ELRALAGS +vvrrvrssiisrrsennrernneesseeneeees4. Indianvimial dMLCuroasOPlLe HURANGS weviirriiusiiusiiteeeisieneneeeaeearaee4s Individual animaldate TEGORdS ......tiieiiiiiiiiiiiiiiitieneeenneeeiaeeniieee4s 000308 smorac sazons re aes ZTSeepssttonAScystsiotcerime":+ sDSeeWipaTleeonrsrnitcooortwyaa2yi9n-saoeanrynicGseasveagae Studmyairnehsats o[ecteapcnaxthmo.so!+ 2S4a2t0o3 e--rr------------------------------------tr Authentication . eTCZehoepemospciuenl,deedccbsoiynqsnhiiesmdt,ihnegasnedohfyth1da4et6cltaphraeegyesr,,retfhwlaeetscttchraeecsEhtuiesIdtAoebpLyaythtcohheleogcayermdpiaeattaaseianmtetheissnesroeeopoobrrit,woTeirrteee Rs aa we TJoexfieczoelyogThi.c WFialtshoent,agiDar.tmed.vet, BUSe, He, CVS PGirnotpia3t3h apruantteln, switzerland 000309 PATHOLOGY REPORT rage 4/145 TTeesstt ASrytsitcelme:: Sponsor + ETxEpLlGoAraAtLCoCrHyOL/2T0E-LDOMaIyR GAaCRvIaAgTeE/Stud/yBRiSn/PROaSts 3M Toxicology Services PNrOoTpOaXthno.ho.: Date 24925001303 2Lapr.1993 -_-- Summary : . P8S4aotxhifocemimotarylpehsso)tluodgwyihciwcihetxhahmatidhneabteiteoennstwsaausrbtjpieeccrltfeeosdrmTetodolomanenr1e6ax8lpclSoophrroaaltg)oureyTeDla2ew0ml-eedryaysrcaoetrysaila(t8e4(sgmaavlaegsoe,y Prus/ ros. Toffhoeur3tr0eaetns(tfewelemorameleersa.sasliTcgeonshetodl,arttoitcesllieoxsmedrwoesraeecrgayrdlomauitpnesistaeenadrcehd coonncteaidnaiinlgy fboyusgtaeveangemaaltesdosaensd J, 10 (PFUS) and 3 marky Ac(toEnOttSh)oel(degonrsdoeuopgfro1tuhpresect2er,ieva3et,dmet4n,hte5pveearhniidocdl6e,erieg1sh8ptecaatqniuivemeoalulyss) carofbfoorxeya2mc8ehtdhasyyelsx.ceTflhrleoumlorsaaetl,sl oatfonteh.e grewss Wt2he6rz-eedeaykfitelmrlaeeladetsmaennfdtr-osfmurbeejeaecchpteerddioostdeos gr(oCruoepmcpolwveeetrreey snuebcjreocptseidesto(aneicnrosptsuydyf)o.llTohweieneg allocation I and 2). m1a-ldeasyanodr Agllalndrsa,ts pancreas, kwiedrneeysn,ecrloipvseire,d. spleen, testes, lHyimspthopantohdoelsogi-c thymus and all meaxnadmiibnualtairon organs or awnads mpeesrefnotremreidc,onovaadrrieensa,l tissues with Sacrescemit Findings. ALL animals survived their allocated treatment periods. H0ateupatpthoec5eeln(ld1u0lomafgr/tkhhgye/pdemaraytirnPoFpsHhtSyu)dwyma.aslIepnsretsahenendtpianinncbrogetrahosupsaex2sels(i3go0hftmgg/irnkocugrp/edaasye(t3iemnlgot/mhkeeg/adilancycoihdPoRelOnS)c),e poFaforltlieoaxwloicnrgoirntechoemapplroeeptcteoovsreierssy/oslipunetgrilioeondsic,nelgltrhoeunpehc2erpoasanitdsoc5ewlmalasulleasrrecahonyrdpdeeirdntrgiornpohuypgr6ohuafpdemau2lnedsem.arlgeoTsnh.ee iFnectiudrennecdetoofthpeanlcerveeals oafpotphteosviesh/iscilneglceontcreolll gnreocurpo.sis in group 2 males had als 000310 samoLo6T REPORT rage s/us TTeesstt SArytsitcelne:+ Sponsor + TIExrMpaTleooaxriacctooowlrLoygiy2t8i-SaDeaaryvnicGAeaRsvAaTgEe.Stud/yeRisn/tR0asts DraNotOpTeOaKthno.fo.:i+ 21.ape2l65125900321930 --_--m Matesials and Methods . study Destgn EwpE| Ame EaETfee = Femier man "50 man "| main seed res mua rec rec voenaketta oss ws [ies sm mas ser oer som Lo |mec 0 [0 . as 0 an | we mm aw usm aman san rmesl 0 [0 ws 0 ws [me ae wo amas wn wwe Cle |e ms ws em ses ae wes sas sas deo | 0 ms ws em mas mas eee san ines wo | 3 | 0 m0 wn | me een sess mem asm sees adatnistzation of the Test Asticle pTEeharetisotdew.setreafraattlislcolweoefdwas&`tah1ed4m-idcnaoiynsttr(eorrleecdovgderaroiyulpy1)by1ograrve2ac5ge-ediavyfe.odr (2rt8ehcedoavyevsre.yhiT2ch)lee,irxeeca1ot8vmeernaytqugerfcoreuespe Casboxymethyl cellulose, alone. Necropsy and Histopathology Aztoaltlt.ohueiRneagphrdeasonefenstttahhteeisviaeasstbiiygsnseeudtehsestraumdvpyalpeposeurroi.fodCsto,hmeptlhfeeotlelroanwteiscnigwoeporsreigeasknislwlewerederebpyeprrefexossreamrnevgdeudionniantaiio4l8n . Phosphate buffered neutral formaldehyde solution (10% formaitn) aAsdntrdeernnaaHlla,rdge`lrbarinaadinsn,, gcslolarinttdaos,r;albohngeelaarnt-d,s,stKesirpdnniuedsyisda,ynmdidlefasec,mruirmeasliopnhcaglgluuadsni,dnsg eyjeoisnetWx;iotrhbboinotepetl,imcarrlnoaewrrgveePmiaannntcderisebtauisln,aerp-iatnudcietcamuremysengtcleoarnlido,cn, parnfedepmuatrlieeacltmuasGm;lmaanrldyasr,ygn`xlp,arnodsltiaavtreeera,g,lalnhudan,sgse,spahlaiiryviiaeprshy goolvdaanerdisses,mcsakoinrndd,ib-uslcmaearrlvliacinandlt,essmtuiibdnlteihnog-ruaadclui)ocdea"nsnucmdi,aLtuijscebjaunrne)ruvmsep,alnedesne,Lmliesnutasolmawcivhte,hsicPtlaeeyssat,re'ss,skpteahltyecmthiasel,s; mCuhsypsziconliaedl ugltaenrdisne wcietrhvixp,aravtahgyirnoaidandglawlnldsG,rgatonnsguoef, titsrsaucehsesW,ituhrimnaacrryoscbolpaidcdesrb,nomumweAeLrLutsiesw.i,th 000311 samoror mezoms we ens STToeersnttsoASrrytsitcelmes:| mSDxToparloonrriacctoosrtoyoaLy26as-edbraavyicCreasvEag)e StudJytiinehnasts FBWurOsTcpOaXthno.ao.+ P2N S42051303 ere er---------------------------------------------- Materials and Methods BSDFlrovolCecelneoormwasiitannedgrpsaarfnaiedxnnaststhsisebotesnade,idsneedtdhIewnitpfhAorlPalefosiwaiitnnognwyainoi.rngaS1nenscdtisofonrvsoimnweraMelel cmuratneiamnSatls,setihowioenremeas sotrfoimmee2d-,4 EAidesseenniatolauctsgslao(nF0d)s,tio(o2v)au,csiekswiidtn(h3e)y,msacpra(2on)cs,eceonpltiicve(Fr1)a,a(t2sn)pg,lee:einyep(h1),novdeesces- mandimbumimer, ((22)) tannt alI(neontindehesiiacllSmeleiymcCsmosiaeneccsrtaoidproyayn,dsovf2oeofsl(yltvohovaeliionismgobacroahvtieaisio.eonorshgsaaxi1nassssoinfd5arcoim(oFnaiv,leslr)esmewaceaitxdniion6snttsnu(eds5ty.epofeSaotvassenintwooennrsTeeoenmengyxammCTiiionaoneeteddPseb,y1BY Erm houp an 3 malin of vecovary ailecations 1 nt 5 wore sho mene" he sections were in Februacy/Mazch, 1999. Data compilation HhRThoreeceeoaMipnimetcynelaorlnacvdoaptidacatsafnidnfdimilanecgsrsooswfceorRpeiOcOrKefcioinrnddtieendgsthBeyv.erccheoemtepliwevmcectrerroasnfiiooceaelnnlyvbEattzhSsomosaimfaeerrsnzseadCnfrloomhutnbheeer RMDMacaactcrrarooossssRcceooocpppoiiireccdaFrFif.inindndiWdinhingsng:rgssa"veaarzneaposipsnriebsAlueeln,ltemddaecsricenrsicpsotpuiivmcearfyfaersmiienngsitnhewcehreteabimlaoedsievIeinrscseinedssenvAcmeiirneo:sf VoSMaifibtclAhreLo.LsGcr"Moaiipdnctdercisov.sficidoTnuphdaieilneygMsaFixicenardoefisuncpgLotsip:hsieteraendFgdiifnv"oderIinnncegiiasndc"ehnFcuaaelnnldiTmaadsbleulsmecaerlaio=rpnitgSvieevwldeietcichtneodsmhemMveieirctnirotobtychieoegrnnrtaMedSieensnFmciiiinnnidieiirntnnghtsse AAnlisztrailbutDuitoan', Rseecvoerrdiatry., anHdismtoolrompeileopciheangcehsa.tscweerees.. Sescribed acessing te their 000312 PATioLoGY Ravers Page us TTSeepssottnsAoScrytsitcelne:1+ m3TxopmTloosxriaNcteoowlrooyrq/y2i8S-ne0aradvynicGAeaRsvAaTgEe)StudfyomianrerRoasts NDPOarTtoOepKatmho.ho.:i+ 2Lapr24si2ss00s31s30 Rosita . Hozeality ASacfreimfaliecegrRoTw o3thexrat,Fatnso.su1r2v9i,veddietdheait abslsoiogdnesdamspcluidnygpeerniotdhse. day of scheduled Haceossopic Findings RTohte dfiosutimnagcuriosshcopcirceatfeidndirnagtss rfercoomrtdheed avtehiaclllesaccernitfriescesgrovuepr.s unremckable and did Microscopic Findings mtThirene.iamteamnledntoorfresltlahitegehdtmamiidncergorssetceuodpyii,nc msfiiidxnzdoignnarglos/wcween3rtsri(nltooetbleuodmlearirn ahtlyhipeoehreltlir)voeprhmyialnewdasspamnsicenreienmaasls. oAtts pmSaoezdxetesir.saltleByydeotgrhreeceosmenpdlinetoaef1l1ythgrereosuo2pl0v-e5dday(nPFrAeg)croovmueaprtye2spaeanrndido5dslml(arlgeercsoouvapesrdy6 i9(n)PeRgnOSrt)osuprfaivnedfioenfmgslBeonsce,hd Rowever enained in svidence in group & males. 2oIfn2"et0hxFeoctrphiaennecmraesispnsopstatousadilyai./gshTithnegilniecnrcceieadlselencneiencorftohsteihsiisnvcafisidnedrniecncegorodrfeedtmuirinnniemdgarltoovoerth3eslmiTogelhvetesl doseefg. eethehese Vehicle control grow following the recovery periods. WTtihhteihsirnaegmetahienadnredarnsgotefraoiftnhebaacnmkdigcrrooocuscncudorpripeacdthafotilnodgSiyinmgieslnacrroeucniotnrecdrieedddenicanets SbpaorntadhguesmeevcDesarovipitaeyisesir,naswbeoortfeh control and treated rata. 000313 PATHOLOGY REPGRT rage 8/146 Test Test ASrytsitcelme:: TExepilonraAtLCoOrHyOL2/0T-ELDOaWyR GACaRvYaLgATeE)Stud/yemiisn/erRoasts PNrOoTpOaXtnho.no.: 2452001303 Sponsor + 3M Toxicology Services Date. t 21.apr.1999 conclustons . Maocrcpyhloaltoeg/ic al/tPeFrEaSt/iFoFnOSs bfyolloonwciengdatihley agadvmaigneisttroatSipornagoufe TDealloemeys raaltcsohfoolr/Ttewleonmteyr iFagthstanddaysi,n twheerepapnrcerseeanst oifn ttehleomlerivealrcoohfoltetlroemaetredalrcaothso.l, PFHS and PFOS treated GHreopuaptocSel(l1u0lmarg/khgy/pderatyroPpFHhSy)wmaaslepsresaenndtininbogtrohupse2xes(3o0fmgg/rkougp/da6y (t3emlgo/mkerg/adlacyohPoFlO)S,) o2f tehxeocernidneOf atphoeptmoasiins/sstiundgyl.e Icneltlhe npeacnrcorseiass awassligrhetcoridnecdreaisne ignrotuhpe i2ncmiadleensc.e Following paztisl or tchoemplreetceovfeersyolpuetriioondsi,n gtrhoeup h2epaantdoc5elmlaulleasr ahnydpeirntrgorpohuyp 6hafdemaulnedse.rgoTnhee Irnectiudmeendcetoofthpeanlcerveeals osfpotphteosviesh/iscilneglceontcreolll gnreocurpo:sis in group 2 males had also 000314 PATHOLOGY RERORT nage 9/146 TTSeepssottnsAoSrrytsitcelme:;+ TE3ExLTpOolGxoRriacAtoCoolHrooygL/y2TH-SLDOeaWrEyvRicGAeeRYsvIaAgTeE/Stud/yemiisn/eRroasts PNrOoTpOaXthmo.ho:. Date b 24525903130 21npr.ises Inctdance Table = Macroscopic Findings Mata study nose sGaodxus mbesofantasis aPman 0s 6 er 8s 8 8 tangs Remochage Stomsch ---- Laver Satarged eo 0 a 10 00010 00010 pee Pelvicdtlation Tastes Radicod10size os 6 0 0 0 0 oo 0 010 Epuataymides Radicedtnsize oe 0 0 0 10 raster atacy cyst | ome . mTaHz s ase 005 000 000 0 10 10 0 oc 5 0 0s os ew 000 000 000 000 00 0 100 000315 `PATHOLOGY REPORT Page 10/246 TTeessttASrytsitcelme:: TEoxipoleonrAatCorOy O26L-DTaCy LAGCaOKvLaNNgTeRE/Studfyemiisn/eFroasts PNrOoTpOaXthno.no.:: 20925003130 Sponsor: 3M Toxicology Services Date 21.2pr.1999 Incidence Table -MacroscFoinpdiincgs RecoveryAllocation 1 Dose Grsaeex: umberofantasls Liver Acbceetnttourssted lobules rT az 3z 00s6 33 0 33 03 3 60501 Reduced dnsize sun `MGBoepneaetrcattlaagton Seahddonfionramlatrieognion o 1 0 os 10 1 0 00 0 0 0 00 00 00500 mT ass 034 z s 6 3 3 3 aaa 0000o0 o 0 1 0 o 0 00 o 00 00 1.0 0 a 0 0 000316 PATHOLOGY REPORT Page 11/146 TTeesstt ASrytsitcelme:: TEoxpLlEoRraAtLoCrOyHOL2E8T-LDOaGyR AGCaUvIaNgTeE/Study/emiins/eRracsts PNrOoTpOaKtnho.no.: 24529903130 Sponsor i 3M Toxicology Services Date. 212pr.1999 Incidence Table - Macroscopic Tindings Recovesy Allecation 2 Dose Grsaevxe:: nusbesof sntaals Bes RaTodnusc.ed 1n size sTaUz: os 0s 6 303 3 3 3 a 0o 100 mTaza 0s aa 433g 0500o0 000317 `PATHOLOGY RERORT Page 12/146 TTeessttArStysitcelme:: TExEplRorAatLocryoR2o-DLa/yFAeGCaiRvIaaLgAdeTRE/Study/omiins/eRroasts NOPrToOpKathno.no.:+ 24923003130 Sponsor: 3M Toxicology Services Date t 21.aps.1999 Incidence Table -SelectedMicroscopic Tindings withGrades Mainstudy DoseGsacxe: nusber ofantaals Liver usher axaatned Mi`hdcyaspnoecrnrtairylo/opbhuyl,erdiffuse (GTraelkaa=inatl))) om1 sWaxes 0s 6 se 8 8 5 8 se sos 3 8 o3 sc1 oo9 500 9&2 692 6 o 5 8s 8 rTa0z2z 03 8 os 8 8 os 8 o0 o0o o00 oo 0 Pancras [R-- ApR(oaapcntrioomssattlsa),/at`asgxloerinceoll (aight) Tomar CI EE EE i1z4 02 10 02 11 262122 2 900 00 200 4s 6 8 aa 880 00 00o 1 3 0o 00 10 00 010 000318 PATHOLOGYREPORT Page 13/146 TTeesatt ASrytsitcelme:: TEExLpOlMEoNraAtCoOrWOyL/2E8H-LDGaGyR GACaRvYaLgATeE,Stud/yeriisn/eRroasts PNrOoTpOaXthno.ho.: 24523003130 Sponsor + 3M Toxicology Services Date. 21.apr.19s Incidence Table - Selectsd Recovery Allocation 1 Dose Gsreavxe:s ousbesof antaals Liver [-- Mi"Edcyospnoecnsratirolo/osbhuyl,erditfuse {o(naroidineigcaa)at;e) omar Microscopic Findings with Grades rTazz2345 6 3 03 3 3.3 03 mTazz 03 333 3s sss 0F[aI 1 o 1 so:1o 0 1 23 oo 4s 6 aaa a 53 1 Recovery Allocation 2 ost rsoevexs Bumbo of antsals Liver p-- Mi"dceznotnrairl/obular B(ympioasitzralo)phy, diffuse (m(oaduegrhatt)e) Tom1 Pancress number exaatned A`paocproossttaa/,atenxgalcerinceall aintaai) sTaxz os 4s 6 3 03 3 03 33 m1a2z 03 4 os 6 3333 3a FE sss 3 0[oI o1 11 00 51 1o 1 3 0 1 ss ie 000319 PATHOLOGYREPORT Page 14/146 TTeesattASrytsitcelme::TEExLpOlEoRrAaCtOoHrOyL/2T0E-LDOaEyRAGRavIaAgLe.Stud/yemiisn/eRroasts PNrOoTpOaKthno.mo.: 24525903130 Sponsor +3K Toxicology Services Date. 21.apr.1909 Incidence Table -MicroscFoinpdiingcs Mainstudy Doss asnoouxp umberof satmls Lanes p-- IRntercaa-paivaerstiearfabcltood, VaaTslecnauellr,aaietantion, Stonsen rusbor exastned Liver usber examined InTfoclkammatory coll Staglecollnecrosis Mi`hdcyzopneocrnetnirl/oopbhuyl,erdiffuse Hiepcautoolcsetliloulnar Hefmoattopotetic cell Conotgaula'tiveneceosts, Paneress [Sp-- ApoRpetcocosstlas/,sisnxgelceticneell Egoefocctaloe stn, sTasos 0s 6 s 8 8 s ss 1 1 1 1 56s888 eo 8 5 8 8 8 ss 6 3 6 6 6 o 0 8 8s 10 0 0 3 4 3 0 000 9 1 60010 5 5 5 8 5s 8 262122 1 1000 mTa0z203 4s 6 8 so 8 8s a 588886 885888 765354 000008 10 10 1 0 000100 0 ao 0 0 o 8 5s 8 8 1 20001 0 001000 000320 `PATHOLOGYREPORT Page 15/146 TTeesstt ASrytsitcelme:: TExEplRorAaCtOoRroyL2/0F-EDLaEyRAGCaNvLaAgTeE/Study[eimsn/eRraosts PNrOoTpOaXthno.no.:i 20923003130 Sponsor: 3M Toxicology Services Date. + 20apr.1599 IncidenceTable ~Microscopic Findings DoseGsaepx:i saeu s umberof sataals 5 8s Pancress Tgfnrfralneacmsiaoetciiyoenni,e/atxed Kidsoys number exaatned TuCbourltaircalateophy, Initnefrlsatmmiattiiaoln, Lymphocytic Hyaline cost(s) Tu`bmuilnaerra.lization Peylmvpihcoitndflammation, 00 CE 30s 5 3 01 2 11 0 10 01 Pelvic dilation Cystictubules Pelvic mineralization Tuhbyupleartrroepphteyh,elifaocal Testes nusber exsatned 00 00 10 00 585 SpSeorlmiatoi)ate glast 10 0 Senattnrotpfhayons tubular 10 0 0s 6 888 010 03 4 6 132 202 000 000 00o 011 000 0 oo 880 001 010 . aTz0z232 888 oo 0 4 12 00z 0 05 0 1.0 0 0 0 0 10 000 1.0 0 00o 4s 6 88a 00 o 1 0s 10 3 00 0 000 00 0 000 110 000 01 000321 PATHOLOGYREPORT Page 16/146 TTeesstt ASrytsitcelme::TEExLpGlEoRrAaLtCoOrHyOL2/T6E-LDOaEyRAGCaRIvLaNgTeE/Stud/yPSi/nerRoasts PNrOoTpOaXthno.mo.: 24923003130 Sponsor + 3MToxicology Services Date. 21.pr.1999 Incidence Table -MicroscToinpdiincgs Dose Gsoovex: sae u s 0s 6 mbes of antaale s 88 8 8 3 mTas2 z 545 6 sos os os 8 ow Eplataymicas usb exaatned 1 Asrophy 1 Aopormta 3 oumsies usher exantned 5 8 ss 8 8 uterus usber examined x ee) 3 Adcanal Glands [p-- Extracapular nodule VacSuiatiattiiotne,tcna2l. Fasicuiata . Attrohpohyn, cortical Solean ousber exeataed HompCsropihoaeatocepisaltytse,sts Homosidorta pigment ss s 8 85 8s 00110 00002 oo 0 0 0 1 s8 8888 es 8 8 8 8 1 0s 7 4 4 88888 011011 0 0 0 0 0 a00000 888888 788583 888888 Tous susber exsatned Lvysopthuottdioantrophy = 586588 0 11 0 2 883888 11 3 111 000322 PATHOLOGY REPORT nage 17/14 TTeesstt ASrytsitcelme:+ TErxpiloonrAatOorLy 2T8H-DOaUy GAaCvaNgeEStud/yemiisn/eRroasts Sponsor + 3 Toxicology Services PNrOoTpOaXtnho.no. Date i 20523903130 2l.pr.1s88 Incidence Table - Microscopic Findings Dost scrxame: sass eos 0s 6 mxmbesof animale sss 8 8 8 Thymus Lyrmephaorcyetdetysts, Mesenteric Lymph Node ausbor exaatned Lo cronogpemsatgiooncytosts 01100 se es os 10100 Handibuler brash Vode [-- Plasmacytosts Lyphold hyperplasia Con"rgyutshtroipohnagocytosts ss 5 8 8 8 se 03 2 2 200100 0 1 12 0 mUa7ns 3 4s 8 8 8 3 8 oo 0 11 11 0 8s os sos 000 0 a 0 888 003 2 112 000 308 112 3 10 0o 000323 PATHOLOGYREPORT rage 18/146 TTeeasttASrytsitcelme:: TExrpilonrAaLtCoOrHOyL/2T0E-LDOHaIyRMGRaYvIaAgTeE/Stud/eyriisn/erRoasts *NPOrToOpXantho.no.: 24923903130 Sponsor + 3M Toxicology Services Date i 21.2pr.1999 Incidence Table - Microscopic Findings Recovery Allocation 1 DossGsreaxm:s ausber ofantnals rTaz0z203 0s 6 5 03 30333 mT az 34 z s 6 33333a pres ousbor exaatned ss 3s os 3 InTfolokammatory coll 3s 3s 3 5 Stagecoll necrosts 2a s2 2 1 Mi`dczooncnrniyl/obular o 1 23 1 hypertrophy, diffuse Hveapcautoolcaetlilounlar oo os a o HoTmoaottopoteticcall 01 ooo o panecess umber exaatned FE Exfoocornilne atrophy, 01 Testes usbes exaatned 1 1 Setmrtonsihfoyrons tubslar 1 1 su [R--, 1a I`nefxluadmamtaitvieon, 10 000324 `PATHOLOGY REPORT rage 13/146 TTeessttASrytsitcelme::TEELxpolEoRrAatCoOryHO20L-D/aIyASGCLaLvOMagGTeEA/Stud/yPSi/nerROaSts PNrOoTpOaXthno.no.: 24529903130 Sponsor i3M Toxicology Services Date : 21.2pz.1599 Incidence Table - Microscopic Findings RecoveryAllccation 2 oose Gsraovxes usbesof sntaals Liver usber exastned Infolcatmmatory coll Staglecell necrosis Mid`hcyzoponencrartilrlo/opbhuyl,erdiffuse sTaom.s 4s 6 3 03 3 3 03 3 mTaOss a 4s 3 3 3 3 aa ss ssa 3 3s sss 3 22 22 a 2 1 so 1 HVeepcaitoociealtliuolnar FR 11 oo o Cofaogcuatlativeneccosts, 1 oo 0 o Pancress ousber examined ss ApRoepctroossttas/,ateaxgolcericnaell 1 Es musbor exeatned 1 FboTlrtnoooerdabimscaaamalpltiidnogien to 3 000325 PATHOLOGY REPORT age 20/146 TTeesstt ASrytsitcelme:: ETxrpolmoaraAtLoCrOyHL/2F0E-LDOaNyA GACaRvYaLgATeE,Stud/yeSi/nerRoasts PNrOoTpOaXthno.no.:+ 24529003130 Sponsor: 3M Toxicology Services Date + 21.apr.1989 Individsal Animal Microscopic Tindings Codes and symbols in cable heading: a ales remles Codes and symbols in antmal lines: 3 Planned sacrifice (main study) = Recovery 1 (plamed sacrifice) 5 Recovery 2 (plamed sacrifice) o other Grading system used in finding nes: finding not present 1 mate 2 sug 3 moderate 4 severe 5 very severs x present only organs/groups with findtags are listed in the table `000326 samoroc sescas re 21s TTSeepssottnsAoSrrytaitcelme:++ TD3xhpoTlmoosxriaactooolrvoyog2yL8T.s0eaurdvyicGAeaTsveEge)Studfy imn sRats NPBOaeTtoeOpaKthno.no.+ ape 2l4829i9031n30 Zadividul aatesl Meroscopie Tindiogs . : Males, Dose group 1 EE secsopay seats EE tives Tnctamatory call Fock doz zz oa 122 singe colt necrosis oe 111112 oe Repacocetiutas vacuotacion oo 5 0 0 1 0 Bemstopotatic call fost ie 1 0 0 0 10 -- Moopots/siogie cil memsts, 0 0 1 0 2 0 0 0 waors nites avs, corstest f Tomemoereie p [ER zostes spasmaciat giant calle) seminicorous nde aszty spleen Reemroptonteesmtesi, epsrisactty Hamostaortn pigmane Hanatiuies Tyeeh ode Flasmacytosts Symphotd hiperplasta ooo 1 0 1 o 1 oo 0 0 11 a 1 oo 0 0 0 o 1 0 e.1 0 0 oo 0 0 01000000 222 111 oz oa eo 1112 oz o1 0 2 oz zz 0 3 0 0 zz 5 0 oo 0 000327 `PATHOLOGY REFORT rage 22/146 TTeesstt ASrytsitcelme:: TEExLpOlRoRraAtLoCrOyOL2T0E-LDOaGyA GAaCRvYaLgAeTEStud/yemiisn/pRroasts PNrOoTpOaKthno.no.:i 25452091303 Sponsor + 3M Toxicology Services Date. t 21.apz.1999 Individual Animal Microscopic Findings ales, Dose group 1 51 necropsy status Liver Inflammatory cell foct Single cell necrosis Hopatocellulas vacuolatien Pancreas Aoeoxpotcorsiinse/atngle cell neczosts, sox 23 oz OO m1 oz os 22 11 11 00 . ou ous ss 2a 1o 0 01 000328 samuosoar Rezoss rage 23/16 TZSeepasectnsAeSrrytsitcelme:1+ TD3meupaTluoonwriauctcaootrwoyosuy2/9fS-neDoradvyhicGseasvoagwe Seudjyemien/eFnass DNParOtoOepKathne.ne.|b 24S2290313 2Lapr.asss Individunl Atal Merosceplo Findings Winer Boss oot 2 necropsy status tive Inelamasory call foot single cont mecrosts KaSdyspoenratlz/ocmonnyc,etdiiofhfuutsaer sumcress ooeprtesat/stngle coll necrosis, Exocrtne atzophy, focal Kidneys Tuer acsephy, coreical InTtieertshteiccrieaire taftemmaticn, altne caseia) nes atneratzation revi stnezatzacion spew Hermeogpolaesiins,tpsrinastly Hemostdarin pigeent Nesentestc Lymph Node Congustion/ecyheophagocyiosts Handtiitas Lymph ode Flasmscytosts n Bd Prop tora Te 0 or 1 02 vo 22 a1 a1 2 23 ou po 2 2a aaa 2 0 oa 21010211 0000001 dr 01 1 ae oo 0 0 1 0 0 oo oo 0 o 1 0 0 0 1000a00 1000a00 Po a1 2 a a e112 1 aaa 0 1 0 oo 0 0 2s oz 0 2 o 2 oz 000329 mammoo0r sasoRT rage 20/146 TTeesstt ASrytsitcelme:: TEmxipaleonrnaetoory 2f6r-iDaeyn GAavAagSe Studjyesin/eRasts PNrOoRpOKatnho.mo.:+ 24s2s903130 Sponsor + 3 Toxicology Services Dace + 2napriaess Individual Animal Microscoplo Tindiogs : Wes, os gop 3 necropsy status sever Tatlamatory cold foct Stagle call necronts Hiydpzaoznzaolp/hcye,ntdriiflfoumsaer Hemstopotatic cell foot Goaputative necrosis, focal Sancrens Excceine atzoph, focal Testes Semtntorous tule atrophy = x 2 3 an sox os as a : 3 sz o2 2 111 0 aa 10100 10 oo oo 0001 01000 ` : 000330 samozoar nazons ase 25/146 TTSeepssottnsASorrytsitcelme::i BT3xMrpihTcooerxaiAtccoesrlysosu2y8i-SmDeRaryvnicGKeaosvaRgNeYStudy/iinmaFeasts DPWarOtoRepCaKthno.so.ht 2ape2i43s2500s01s30 Individual Matas Mesoscopic Findings Ries, mis gop 3 u = 3 a 3B 3 40 nessopsy states Live Intlamatory coll gost stagle cont meczosts suncress Pv vo po 3 doa 123 22 a Tao a1 aa oe | rine Apoptosis/single cell necrosis, 1 o o 1 Exocrine tzophy, focal oo 0 0 0 0 1 0 xidneys Tubular atrophy, cortical Be 0 a1 0 1a T Tnecyep ie ---- or 0 10 0 0 0 Pelvic inflamcion, ymhetd 0 0 0 0 0 i speen Heemroypiontzeasptosi,ssipsrimactly : 1a 12 22 oa Hesosidert pigment Te 0 0 11 aa Thyme ymphetd aveephy - dvelstion 0 0 0 0 0 1 0 Iumphocytolysts, dnceeased os 0 0 0 0 0 2 Mandizular Tymgh Node Flasmscyeosts oe 2 0 0 2 2 0 0 Congestion/aryiheophageariosts 0 0 0 oo 0 3 000331 FaTHoLoG REsoRE rage 26/146 TTeesstt ASrytsitcelme:: Sponsor + TEEXLpGiEoNraMteoOrWyLT2H8L-DOaGyR GAaRvVaIgNe,Stud/yomiian/eRroasts 3 Toxicology Services PNrOoTpOaKthmo.ho.: Dace i 20s2s5a3t30 21pr29%9 Individual animal Microscopie Tindings : 0, Dose grorp 4 neceopey status Laver Inflammatory coll tock single cell necrasts R4O9 so 51 52 53 54 55 S56 ov Pp pp : a 112 zz a 11 0 0 0 10 0 romptopta/stogle ctt seczots, re--. bar atsophy, cortical InTtremseseecirttiialc inflemation, Hraltnecast (s) Adzenal Glands Exeracapsular nodule spleen He"mvctpaorteepsetise,sipsrimarily Hemostdertn pigment hrm Lymphotd scsophy - Smeets Lymhocyiolyats, incensed Hesentazic yugh ode Congestion/eryehzepagocytasts Mandibular Lyegh Node Plasmacyronts Lymhotd hyperplasia Congustion/erythecpragocytasts 0000020 10 0 0 1 0 0 1 oe oo 0 1 0 oo 9 oo 0 1 0 1 oo 0 0 0 0 0 x Tz 11 oa 2 a2 a 111 aa 00000001 oo 0 0 oo a 2 0010000 oo 0 2.0 0 2 0 oo 0 2 0 0 a 0 0 9 0 2 0 oo 0 000332 enmmotoc sazoss ese 7/16 TTSorsEetnaAeLsttiecle:| ToSFeurronrAicyootboFy75a-sedoruavyiAcGeRasvNegEe,Stud/yomin/iasts| NBOFarTroGepKatnho.Ao:ang2eS42o0st3o3 Sadtvidual ntaal Microscopic Findings sates, Dosegrocp 4 a osm ow oa a a JE-- sr ox os os a aes Psartoispincas gtnciamasion due to 2 000333 sammoroce saRoRr Page 20/146 TTSeepssottnsAoScrytsitcelme:++ 3TEeMxopwTlenooc xraitcoarlyony2T0s-eObrL aGvyiAcGeaCsvaRgeEStudeynitnreRaets NSPOreToeOpaKthne.no.:+h 24325903130 21aprasss Individual Animal Microscopie Findings Yaes,Dosegrow 3 Receopsy status ung Sntraaivatar biost, mecroey Vascular minasalisation, focal Live Inflammatorycold tock single callnecrosis Mipcezroenza/ocmennyt,etdiiothfuulsaer Hepatocellularvacuelation Coapilative necrosis, fol Pancress aRpcoripnte osisc/elslinencrgoslise, Inflammation, mixed granulocytic/lymphocytic Kicnays andaratrophy, cortical InTtrenrsotristiiacl inflammation, Cystic tutes Testes Setnttorons males atzomy Eptataraides Aczopny Aspermia s & go & & 7 M2 pp 5 5 x : 21 oz FO sss de 1 001 oz oz 2 oz 2 ss 22s 0 0 oo 1 0 oo oo 1010 0 0 0 0 1 oo 0 1111 0 oo 0 11 0000 04000 a x oo ao 1a0 oz 0 000 000334 `PATHOLOGY REPORT rage 29/145 TTeesstt ASrytsitcelme:: TExopwloaraAtLoCOrHyOL2/-TEDLaOGyR AGCaYvIaAgTeE/Stud/yPRNiSn/ERr0asts Sponsor + 3M Toxicology Services PNrOoTpOaKthno.no.:: Date t+ 24523903130 21pe1999 Individual Animal Microscopic Findings ales, Dose group 3 6 se @ 1 on om neczopsy status Pp Pp Adzenal Glands Extracapsular nodule 0 o oo x oo o 0 spleen HeEmyoiphoztoepsotlse,sipsrimarily 2 1 oz 1 1 2 1 2 Hemosddortn pigment o 1 0 2 oo o 1 z Mandibular Lymph Node Plasmacytosts o 3 2 o o oo 2 2 congestion/erythrophagocytosts 1 0 0 0 0 0 2 000335 samoLo REvoRs Page 30/146 TSTpeeesnnttsAoSrtytsitcelme:+ rE3xMepelToorrxaiatceoaorltyoogL2y/3T-S0eaarGvyRicGAeaRsvaTgeEStud/yemisn/imRoasts EDNarOroRepCaKthno.no.:1t 2tapr2i4Si20s9e30s3 Individual Animal Microscepto Findings . sates, Dose geop 5 now om om om om neczopay status Liver Satlamatory colt tot single call mecrosts Mipdezrosnraolp/hcya,ntdriitituosies Hepasoceltata vacuolation Testes Semtnttazous tunlar atrophy sor ox sa a soz oz oz 2 2 : 1111 2 0 1 0 0 oo 0 0 oo 1 a 000336 PATHOLOGY REPORT Page 31/146 TTeesstt ASrytsitcelme:: TEExLpOlMEoRraAtLoCrOyNL/2T6H-LDHaEyR GACaRvYaLgITeE/Study/bmiins/eRraosts Sponsor + 3M Toxicology Services PNrOoTpOXatnho.no.: Date. t+ 20929003130 212pr.1ss Individual Animal Microscopic Findings . ales, Dose group 6 a om ow ou os ow owow necropsy status Pp PP iver Inflammatory coll foot Single cell necrosis Wdhzyopenratlr/ocpheyn,tridliofbfuuasre. Hepatocellular vacuolation Hematopotatic cell foct 22221222 10 11 0 111 23333233 1 1 0 oo 1 2 oo 10 0 0 0 0 o Pancreas Mp`oexpotcorsiinse/single cell mecrosts, 0 2 0 0 0 0 0 1 ianeys Tubular atrophy, cortical InItyemrpshtoictyitailc influmation, Eyaline cast(s) cystic cules 11 0 1 1 1 1 0 6 0 2 1 0 o o 0 00oo110 02oooo Tastes Spermatidic glant cell(s) 0 1 0 o 0 o Adrenal Glands Vaacsuioclualtaiecna, miltifeesl nz. Atrophy, cortical diffuse 0000101 0 oo 2 o o o oo 000337 PATHOLOGY REPORT Page 32/145 TTeesstt ASrytsitcelme:: TEExLpMlEoNraAtLCoOrHyOL/2F0E-LDOWaGyR GACaRvYaLgITeE/Study[emiins/eRraosts PNrOoTpOaXthno.no.:+ 24923903130 Sponsor + 3M Toxicology Services Date. 21.2pr.1999 Tadividaal Animal Microscopic Findings - ales, Dose grow 6 mm es ss ss 8 6 necropsy status Spleen Heemroyptohtreosptost,esipsrimarily Hemosidertn pigeant Thymus Lymphotd atrophy - fwelutin Mandibular Lysph Node Plasmacytosts PP 3 111 1121 a 11 1 0 0 0 0 1 0000o201 3 0 0 z o 0 0 oo 000338 `PATHOLOGY REzoRT Page 33/145 TTeeastt ASrytsitcelme:: TErxpiloonraAtLCoOrHyOL/2T6E-LDCHaEyR GAaCRvIaAgTeE/StudmyiSi/nprRoasts PNrOoTpOXatnho.no.: 24323503130 Sponsor i 3M Toxicology Services Date. : 21.2pr.1999 Individual Animal Microscopic Findings . ales, Dose group 6 8 0 ss se ss necropsy status Liver Inflammatory call foct Single cell necrosis Mdzhoynpaelrt/rcoopnhtyr,tidiofbfuutsaer Hepatocellular vacuolation oxox 222 11 0 233 12 oz sss 122 10a 13 2 0 10 000339 sammoLoot FazoRs rage 34/146 TTeesstt AScytsitcelme:: TExipalonrnaetoory 2R0-ADGayR GAeRvAaTgeE)Stud/yeRiisn/iRtoasts PNrOoTpOaKthno.no.:3 20529903130 Sponsor i 3 Tomicoloqy Services Date 21ap1999 Individual Animal Microscopie Findings . Fecaioa, Boce grep # neceopay status saver snflamatory colt foct stagie cond necrosts Hepatocellular vacuolation sancress ApRoeptionsteo/single call mecrests, Kidneys lar atzophy, cortical lar stnesalizaion Pelvic tzeratzation spieen Hermyoiphootepsotise,sipsrimarily Hemostderin pigment hms Lymphoid sezophy - dmveluten Handler Lymph ods Smphotd hyperplasta F 97 E98 E99 S100 STE 101 102 103 104 2p 2 5 op > : a 2 12 22 oa FO eo 0 0 0 0 oo 1 1100000 10 0 1 0 10 a oo 0 1 0 0 0 1000000 1a oa 1 0 11a s 2 zz 3 3 2 2 0000010 oo 0 2 o 0 000340 PATHOLOGY REPORT rage 35/148 TTeesstt ASrytsitcelme:: TEHxLpOlGoRraAtGoOrWyL/2S8I-DOaEyR GAaRvIagAeTStud/yoRiisn/eRroasts PNrOoTpOaXtnho.ho.: 24525003130 Sponsor + 3M Toxicology Services Date 21.apz.1993 Individual Animal Microscopic Tamales, Dose group 1 necropsy status Liver Inflammatory coll foct stagle cell necrosts Hepatocellular vacuolation sen Inflammation, exudative Findings 10s .1f05 =r 22 11 2 2 . 107 109 fm0 fam x sss 2221 0100 oo00 000341 `PATHOLOGY RERORT rage 36/146 TTeesstt ASrytsitcelme:: TEHxLpOlEoRraAtCoOrWyL/2S0L-DOaGyR GARaTvIaAgTeS/Stud/yERiisn/eRtaosts PNrOoTpOaKthmo.mo.: 2432081303 Sponsor t 3M Toxicology Services pate. t 21.apr.isss Individual Animal Microscopic Findings Esta st ams necropsy status ver Inflammatory cell foct Single cell necrosis Kidneys Tubular atrophy, cortical Pelvic dilation dcenal Glands Extracapsular nodule spleen Heemroyptohtreosptosi,esipsrinarily Hemosiderin pigeent hyms Lymphotd stzophy - fvelusten Lymhocytolyats, increased Mandibular Lymph Node Plasmacyosts Lymphotd hyperplasia meofm Po :2 11 oo 0 0 11 22 00 0 22 20 - fousofus ofw fme vo? ufs f120 @ 11 1 11 2 0 1 0 11a oo o 0 0 1 0 0oxooo 0 oo x oo o 0 1 1111 222232 0010 0 oo oo 1 0 o o 3 0 oo o0oo0 000342 emaouoor sasoRs rage 37108 TTSeeossntteeAStcytsitcelme:r| TESrxTpirleeosrrianctaetrotyay2o6-sDenvryvicGAeasrveTgs)StudpyoinmFsavs NPBOrRoaOpKarthnoe.ho": avape2i4Si20e9t31s3 Individual Animal Meroscople Teams, Dose grep 3 necsopay stavus sie Intiamatory coll fost singe ceit reczosts [E---- Sancrens Exocrine sexes, focal wanes [TR ------ ITntiemrpsreoirceiialc inflamaticn, Arena Glance Erssacapsuia node spleen Rermcpaotesrts,eprisacily Hesostdertn pigaent me Lymshoid acrophy - weistion Limphocytoiysts, inceessed randiuiar yeh ode [E---- Lymphotd hyperpissta Findings P womEmP om P ows E we R ms 16 x vo op ob po: ox a2 o1 a 2 tr: 0 oz o o oa i 0 0 oo 0 601000 1 0 ooo 1 0 0 000010a oo 0 dio veo: 10 oo 0 oc 0 0 00 0 0 oo x oa 2 aaa a2 2 2s 0 1 oo 1 00100 00022 0 oo 2 2 000343 PATHOLOGY REPORT Page 38/146 TTeesstt ASrytsitcelme:: TExepilonraMtcoOrWyL2/8S-LDOayR GAaRvAaTgEe,Study/eiRin/pRroasts NPrOoOpKathno.no. 24529003130 Sponsor & 3M Toxicology Services Date. + 21apr.1999 Individual Animal Microscopic Findings Females, Dose grow 4 fHs fME fWT f8 us 10 f151 f1s2 neczopsy status iver Po Pp Pp bP Inflammatory cell foct 12 1 oz 2 2 2 a Single cell necrosts 1 1 0 o oo 0 1 , Hematopoietic cell foci 0 oo o 0 1 0 oo Kidneys Tubular atzophy, cortical oo oo o o o oo 1 TaLtyemrpshtoictyitailc inflammation, 0 1 0 o oo 0 cystic tues 0 z o oo oo o oo terus cysts) x Spleen Heemroyptohtreospiosi,esipsrimarily 11 0 1 1 0 0 1 Hemosidertn pigment. 2 222 2 32 2 Thyme Lymphold atrophy - fovelutlen 0 0 0 0 0 0 0 1 Lymphocytolysts, increased Mandibular Lymph Node oo 1 0 o 0 0 Plasmacytosts 9 0 o o 2 0 oo Tymphotd hyperplasia 2 oz o o 2 o oo 000344 samoroot FazoRs TTeesstt AScytsitcelme:: TEoxspolneonraatiocrOyRL2T0E-IDAaNyR GAacvTaAgTeE/Stud/yeRWiSn/iRToasts Sponsor MM Towlcology Services perme rere Zndividual Animal Microscopic Findings rage 33/146 PNrOoTpOaXthno.ho.: 2s0s2a3t30 Date i 21apr.19%s etemrrrr Foskies, Doss soo Deceopsy status saver Inflamatory cell foct single cell necrosis Hopatocelludar vacuslation Pancreas romptopa/atngle ct meczots, 1S61 E162E163 1E64 E165E166 LE EE 1E67 y168 : 2 3 oz oa 1a a eo 1 1 0 1 0 1a oo 0 oo 0 1 0 0 0.1 0 0 0 Kidneys Cystic mmies oo 0 0 0 oo 1 Tfuocealr epithelial ypestzophy, 1 0 0 0 0 0 0 adzenal Glands Bxcracapsutas nodule 0000x spleen Heemrovpiohtseesptosi,espirsimarily T1211 aa | emostderin picumane zz oz oz oz 2 2 3 | Thymus. Lymphotd atrophy - fmolution 0 0 0 2 0 0 0 Lymphocyeolysta, increased 0 1 0 ao oo Handiiias Lymph ode Flasmscytosts oz 0 0 o 0 0 Symphotd yperplasta so 0 0 oz a 000345 samoroor seroRs tase dois BTFEeoasoAlrticle:abl maCe srcionuitngsBoSreiuvnereesStutdsoonsmsous NoB OsTpOeKthR no.ne:+ papet24Ei2c9eh9s1 Individual Anton Wieroscople Tindiogs ; Tamales, Dose grow seesspy von river [------ single cult necrosis Mardersoneasecpmntyetailatmetrses raners inter atzsty, cortical InLtaraseivnias fnflumation, Adrenal ands rere 177 178 179 180 RR 181 182 ey 183 184 Pop or vo ps dro o2 oa aaa Dea 01 eae rs a zs sa Dae 01 ao a I spieen pr Hemsricartn pigment ThLyymmupshotd sssephy - dmvolutten Vandibutar yeh Node Pamacysts das 2 a 22 a 1 0 0 0 0 oo 0 oe 0 0 0 2 2 0 000346 pre rage 41/145 TTeesstt ASrytsitcelme:: TExepilonraAtCoOrHOyL/2F0E-LDOaEyA GACaRvYaLgIeTE/Study/NiSn/erRoasts PNrOoTpOaXthno.no.: 24929903130 Sponsor + 3M Toxicology Services Date. + 212pr.1999 Individual Animal Microscopic Teaales, Dose grow 6 neczopay status Liver Inflamatory cell foot Single cell necrosts MidBzypoenrat)r/ocpohnyt,ridliofbfuulsear Findings 15 e16 e107 sor or - 19of5 1r30 E191 sas 11 oz oz a1 a 0 11 1 oe 1 0 0 0 1 000347 PATHOLOGYREPORT Page 42/146 TTeessttArStysitcelme::ToELxpolmoRrAaCtOoHrOyL/2T8E-LDOaEyRAGCaWvIaAgTeE/Study/emiins/eRraosts PNrOoTpOaKthno.ho.:i 24929903130 Sponsor: 3M Toxicology Services Date 21.apr.1983 Animal Data List sales nmou sero. TEST mst mer NMGER M/FSTATE DAYS DAY oar DoseGrove 1 12 ma opp 282 34m3 p op m28 S7 ama ppp 292299 85 aa p 2299 o10mm oorr 22 1Lommom ooosss 222900 DoseGrove 21 om op 20 om p28 2109m= pp2288 2212 =mpp2929 2203ma pp2299 225 amrx 2299 2201mmsx 2299 DoseGroup 303 mmooss 2299 33mmoppa28 336 m=m opp2828 33 mmopp 2299 3"9 mmopp 2239 44 ommo:or 2239 GG5 mmosoz 2299 69 mmoss 229 e05o/s0 ooseos OO0eg0a/ol//o8s/ 0050/1/0/898 0os6/00/8sse 0066/00/5s8 os/lo/ss o0uu/sse ooisee 0 0 01s %S 0033/a8 0033ayss 00331a%m 03AVSE 006n60//se0/020a1u 00/61100//588 0022/111//598 0085/01/0/5588 6033/111//558 0086//100//5588 0033/1111//538 00600//5588 o033//a1i1//s3e8 0068/00//3588 o03y/i1u1//s5s6 0066//00//5588 0033/1iuy//ssss o06s10s/5 0 om z 0066//00/8/00211 008//1100//5588 0033/11//5588 008/610//508 /003311/988 o0s6n0o//5s8e 0 03/11s/se o0s6n100//s5 ooyyi1iu//s%ee 0oe6s1io0//s5s 0o3y1u% mmeucrrorsy o03y/u11s/s5e8 o63/y11/e58 o0044u///1i11///ss5ee8 018i//1i11//3s8e 1188/11//0588 o 021z 2/9 02/32/s8 o03/u1/s%8 0G33//111//%% 0044//111L//%% 0044//1111//3%8 119//1111//9988 1082//1112//9988 0022//1122//9988 0033//1111//5588 00331111//99 0044//1111//5988 0044//111//9980 1188//111//9s8 021//1121//58% 0o2z/i1z2s/e5e8 000348 `PATHOLOGYREPORT Page 43/146 TTeessttArStysitcelme::TEExpLloMrAatLoCryOH2O0-LD/ayTAEGRaLvAGaTgEeEA)Stud/yRiiSn/eRicasts PNrOoTpOaXthno.no.: 24325903130 Sponsor +3MToxicology Services Date t+ 21pr.198s AnimalData List : sales amu sm rnow Test Fst sr ome - WMGER WP STATE DAYS DAY DAY MecRopsY ose Grove DoseGroup Dose Grove 44s mp 28 S$1oma pp2828 $$23 omm pp2829 S$5im2 pp2293 $S5 mmrp 2299 S$e5 mmrr 2299 @ == 53 229 5& = a 2 66s m= opp2820 && ==pp 2280 0 == pp2209 T7732 Aoam rpp229929 47T5 amar:3 222999 775 ma aa 2299 6om p20 882 ma pp2828 o9 m2 pp2298 8#7 2= pp2929 88 m= pr 2299 5s0i mmor: 2299 5Si mmss 2299 9 ms 29 o0/s1m0o/s3e8 00/5100//5988 00/51100//998 ooosssaao00///s95e8 00//1100//5588 oogog/som o6/o/se zwzeiyess Gozizu/sss 0G3y1es ooyyee oyyiiysmm 00oy33iua1/smie 03/i/se 006600/5s8 0022ss 006600//3388 0 Qym sm 0066/010//3588 0o3ymu 000446//111000///55588 0G033y//i11u11//s35e88 0006/4/110/0//515880/0O533//011113//5%188 006//1100//5388 0033//1111//3988 006//1100//5%8 00/010//558 00/010//55% 00/010//558 006/010//558 000600/0/0/35%8 00/38 0oz2/15/s8m O Giz ls O 03Y 1% 0033111/%3 Oyyi1/m% oo0yyy/i11Ly//m%% o3/1y/s8 o03y/m1Ls/e% 00y3//1111//%%e8 0044//1iL//sEe 0o4a//1n//s%ee 1ue//1/sse 00l2e2//11u22///s99e8 o2/12/se 0o33//n1/1s/e% 0033//1111//3388 0o4//11/s38 014o6//411/11u///59m88 101826///111121///399888 0022//1122//5388 0033//1L1//%%E 0033//11L//3%8 OO44//L1//%%EE 0044//11/L5/8% 11e8//11L1//s%e 1002ez///1m12/2/s/9e%8 02/12/98 000349 PATHOLOGY REPORT Page 44/146 TTeesstt ASrytsitcelme:: TExrpilcoaraAtLCoOrHyOL2/8TE-LDOaEyR GACaRvYaLgATeE,Study/eriins/eRraosts PNrOoTpOaXthmo.no.: 24929903130 Sponsor +3MToxicology Services Date. : 21.2pr.1999 Antmal Data List Females amon sex roo TEST WGN W/E STAIE DAYS Dose Grove 17 p28 %5 pp 2238 1I00 ffpp 220 llz3 ffpp 220 lllosed fffpxr co229 l1075 ffosr 2200 1191 ffF 33 22 Dose Group 2Is of p28 1BHmes o ppp222888 1m7e oo pp2293 1120 pp2293 m1 fof Bx 2929 112235 ffosr 2233 1w6 f55 2299 DosE GRoue 31130 ffpo 22m L1I2 oof pp2280 1L3iffpp2929 D1s fpp292 1Ie7 fforx 2299 mTS froros 2290 LMz3 or sa 220 FDIARYST. mDAYT o0s8//1100//9588 oo04u/11s/se 0G0888///11000///59s88 0044/111//3388 054% 0098//00//9s8 0 05/1s 1/38 0o08s//8100///9s80/005s81a1y0s/s3 o08/s0/s%8 0 0sAaUs 0oss//00//%s8 0o5/s11s/% o00//s5 o0//0/s58 o0e/iio/sse 00/00//558 0055//1100//5588 00y//1o0//s9e8 0o88//i0o//3s8e o04u//sse 00u4//ili//ssee oos;sa/sse 00s8///s8e 0085//1111//8388 O08/S11/s88 00s5/a11/%se 008//01/0/9588 008/01/0/558 0o8s/s0o//ss8e i08o0es o09e/o0s/m% o0a8//o0//s9m8 0oBb//lioo//ssne 0O40/41/11/n5/8m 00441sm 00s/5au/ssm o0s5s% o05s1/s% o05s1/s58 O0SS/A1L//sSe amcmRopsy o08s//1s1/s3e8 0083//1111//3388 0Oi/s1e 008s//1111//338 2200/1111//388 2040//112//9s8 0o4d//1i22//9e8s o0s/s1/sse 0088//1111//9988 006s//a11//ssee 0065//111//8888 2200//1111//8988 2004//1112//3388 0044//1122//9388 0055//1111//9988 00s5//11L//3%8 0o/m1e 006//1111//3388 2200/1111/9s8 2040/1112//598 0044//22//5s8e 000350 `PATHOLOGY BzRoRE Page 45/146 TTeessttArSytsitcelme:: TEExLpOlWEoRrAaLtOoIrOyL/2T8E-LDGaGyRAGCaRvIaAgTeY/Stud/yemiisn/eRroasts NOPrToOpKathno.no.: 242933 59010 Sponsor t 3K Toxicology Services Date. : 21.apr.199 AnimalData dst . Females nWMmGoIwR WseEx SrTmAoTuE DTASYTS DPASY T mDAsYt wmewcrorsy DoseGroup 4Ls Wg pp2288 00/81100//558 oouaasi/isse o0ss;/i1//sse8 7We fo pop Ms fp 228 0o8//10/s58 o04s1es o0s/s1/s%8 29 08/10/58 OSs 06/11/88 . B1o3 f pp2929 o0//o0//s5m8 oossms 006/61/s88 L11243::fo:bc 222999 0oon/ns10so/9 0o5s1ss oss 0260/71//8988 z0//s I1Bo7s fo23: 222999 ooon/wjliolo//sses oOssiss osm 20041/1a//8e8e oua/se DoseGrove 15 3 fa o a 29 p20 o/o/se oso os/use oases oua/se os/use i1 ffpp 2238 o00n//1o0//s9e8 ooaa/isie/sse oos/su/sse 11664s o pp292 0080/1100//558 o0S4//1i1//sse8 00s//1i1i//9se8 116 pp2299 0068//1100//9588 00S8//1111//5588 0066//1111//5588 198 pr 2929 0088//1100//5588 0055//1111//5586 0260//1111//5588 Wm0 fx2929 0088//100//9988 o0S;su/sse 2200//1111//s588 mfo aa 2299 0088//100//5588 oo0ss;;al//ssee oou4f/iiaa//ssse Das Grove1s 2 23 08/0/58 08/1/58 04/12/38 mIeoeo pp2288 0s8/o10/s38 o0i/u1i/sse o08s//11u/s5e8 1Wo pp 2828 0008//1100//3588 0044//111//sse8 008s//111//s5e8 W12 f pp 2929 0008//1100//9588 o08s//1i//5s8e 0066//1111//5388 1103 pp2299 0088//1100//5988 o08s//1u1//s56e 0066//1111//5s88 1156 rx 2299 0080//00//3588 008s//1a1//s5e8 2200//1111//3588 719 f ox5 2299 O08e//10l/09/8 008/11A/58 2004//1112//5588 11900 33 2239 Oona//iioo//ssee 0ss//i/sse 0044//aa//ssee 000351 PATHOLOGY REPORT Page 46/146 mTeeastt ASrytsitcelme:: TExepilonraAtLocroHyoL2/0A-RDOaEyR AGCaRvYaLgAeTEStud/yeriisn/eRroasts PNrOoTpOaXthmo.no.:+ 24925003130 Sponsor: 3M Toxicology Services Date 2Lapr.199 Individual Animal Data Records AsDeOtxS:mEaGaoNuorp: aV1etheicle Control ACROSCOPTC FINDINGS acaoscopre FromIGs ver spleen MaTndibular Lymgh Node/ Ma2ndliales Lymph Node/ Atma vor 2 acroscopze Fromics dPSaaaycdstroipfosfiyctesrtgearatoutwsment:i: 2tp8leamninneadltseamcirniaflice dGaattee ooff esncdaroefoftrteartemaetnmte:nt:020/61/11/09/098 date of necropsy |: 03/11/58 No findings noted HIenmfaltaompmoaiteotriyccecollllfofocott (s(laiignhtta)al) Hemopolests, primarily erythropoiesis (slight) Plassacytosis (slight) Plasmacytosis (sight) NoKidanbenyo/r2m,alTietsiteess/f1o,unTdesitn:es/P2a,ncrAedarse,nalKiGdlneayn/dl/,i, Mrenal Gland/2, Thymis, Mesenteric Lymph Node. dSaaycsrifoifcetrgeraommuepnt :: 2t8eminal sacrifice nGeatceroposfystsatrtaotfutsre:atmpelnatn:ne0d6/t1e0m/i9n8al cdaattee ooff enencdroopfstyreatm:en0t3:/110/25/811/98 No findings noted 000352 PATHOLOGY REPORT rage 47/146 TTeosstt ASrytsitcelme:: Sponsor: TExepulonraAtLoCOrHyOL2/8T-ELDOaGyR GACaRvYaLgATeE,StudIyPRiSn/prRoasts 3M Toxicology Services PNrOoTpOaKthRo.no.: Date 24929903130 21.2pr.1999 - Individual Animal Data Records . aSnetx;mal wor DOSE Group: Va2elhedele Control MrcRoscoprc FIINGS ver Tastes/1 Testessz spleen Ma1ndibular Tyeph Nede/ rtm wor 3 YACROSCOPIC PTIDINGS. MrcRoscoprc FomINGS Liver Pancreas Spleen Ma1ndibular Lysph Node/ SInifnlgalmemacteolrlyneccelrlosifsock(ai(nstlaisglh)t) Seminforos tubular atzophy (aintasl) Spemmacidic glant cell(s) (minimal) HHaemmoopsoitdeesrtisn,ppirgimmeanrtil(ysienrizyatlh)ropolests (slight) LPylrapshmoatcdythoystpserp(lsalsigihat)(slight) NMo`Keisadebnnenotoyer/rm2,ailcAidLteyiemenspahlfoNGoudlnead,ndi/nM1:a,nPdaAindbcrureleanarasl,LyGKlniagdnhnde/Ny2o/,dle,/T2h.ymis, dEayrs iofstreatmfelnt: Facropay status + 2o0 v he planned terminal Gaattee ooff setnadrotfotfretartemaetnmte:nt:020/61/1/1308/98 Gate of meczopsy| 03/11/38 No findings noted ISHanimfnalgcalomepmoactateloltriynceccecrloollslifsofcotc(isi(ns(ilaziiagnlhi)ts)al) Apoptosts/single cell necrosis, exocrine (minimal) HHeezzmoopsoitdeesrtisn,pipgrmiemnatril(ysienrizyatlh)ropoiesis (slight) LyPlmapshmoaicdythoyspiesrp(lsalsigihat)(slight) 000353 `PATHOLOGY RzpoR Page 48/146 TTeesstt ASrytsitcelme:: TExepilonraAtLoCrOyWL/2T0E-LDOaGyR GNaRYvLaNgIeE/Studyleirsn/pRroasts Sponsor t 3M Toxicology Services PNrOoTpOaXthmo.no. Date : 21.2pr2.45125900931930 --_-- Individual Animal Dats Records . seraxt:aal No: a3te Dose Grove: Vehicle Control MTaeceanotsincuoepdr)c FmmmGS Ma2ndibular Lymph Node/ Antal wer 4 MACROSCOPIC FDIDTNGS `MrcRoscoprc FIGS Liver. Kdney/1 Spleen Ma1ndibular Tysh Node/ Plasmacytosis (slight) NoT2.osac"beTnhsoy/rm1mi,as,lTieMtseitseesesn/ft2oe,urniAdcdrLieyntnmapKlhidNGnoledayen/.dl/,i, KAiddnreeyn/a2l, Gland/ dSaaycsrifofictergeraowtpment: 2t8erminal sacrifice DGaatceioposfystsatrtatofutsre:atmpelnacn:ne0d6/t1e0r/m3i8nal a"attee ooff emencdroofpstyreatmen0t3:/110/29/811/98 Yo findings noted SIinfnlgalmemacetlolryneccerlolsifsoe(si(nsiizgahlt)) Tubular atrophy, cortical (minimal) RHeezzoopsoitdeasrtisn,'ppirgiameanrtil(ymienrizyatlh)ropotests (ninimal) Plasmacytosis (sMsht) NoT2,esatbTehmsyo/mrlua,ss,lTiMetesisteeessn/tf2eo,ruinAcddriLeny:nmaplPhanGNcolrdaeen,ads/,lM,anKidMdienbneuyla/a'2r, GLlyamnpdh/ Nodal. 000354 `PATHOLOGY REFORE nage 43/146 TTeesstt ASrytsitcelme:: ETixipaleonraAtCoorHyOL/2T-TDLOaGyR GAaCKvLaAgTeE/Study/emiins/eRraosts PNrOoTpOaXthno.ho.: 24s2s003130 Sponsor i 3M Toxicology Services Date. : 21.2pr.1999 Individual Animal Data Records rsuaxt:es wo: vSale Dose Gaoup: Vehicle Centel cRoscoPC FwIIGS Macroscoprc PuINGS Liver Pancreas Kidnoy/1 Spleen ratmal Nor 6 MACROSCOPIC PIIDINGS. nsdeaacycrsroipfosifycetrsgetraocamueptnit s:1: t29eminal sscrifics plamad taminal Gdaattee Goff esntdarotfoftretartemaatnmce:nt:030/61/11/03/558 date of neczopsy 04/11/98 No findings noted SIinnfgllaemmcaetlolryneccerllosifsoct(st(nmiimnatls)al) Apoptosis/single cell mectosts, exocrine (slight) Interstitial inflamation, lymphocytic (stntmal) HHeemsooipiodteersitns',plpormiemnatril(y31e4rgyht)hropoiesis (ainimal) NMToeessatebennsto/er2rm,iaclAidtLziyeemnspahlfoNGoudlnead,ndi/Mn:la,ndKAiiddbncueelyna/ar2l,LyGmlTapenshdt/eN2so/,dle,/T1h,ymss, Mandibular Lyzph Node/2. sdaaycsrifoifcetrgeraowtpment:: t29eminal sactifice ndeacteroposfystsatrtaotfutsre:atmpelnatn:ne0d6/t1e0r/m5i8nal ddaattee ooff nenedcroofpsytreatm|:en0t4:/110/39/811/50 Yo findings noted 000355 PamoLosY Repo Page 50/148 TTeesstt ASrytsitcelme:: TExepilonraAtLoCrHyOL2/T0E-LDOaGyR GAaCRvYaLgAeTEStud/yemiisn/eRraosts PNrOoTpOaXthno.no.: 24525003130 Sponsor i 3M Toxicology Services Date. 212pr.1999 Individual Animal Data Records - Asetx:ma No: a6te DOSE GRovP: Venicle Control Mcaoscopre rwnics ver Kidney/1 Kidney/2 Spleen MaTndlialar Lymph Node/ Ma2ndibular Typh Node/ Atma Nor 7 MACROSCOPIC FROGS Mrcroscoptc FrxoNGs iver Kianey/1 SIinnfgllaemmcaetlolryneccerllosifsool(si(nmiiznails)al) ITnutbeurlsatritaitarolphiyn,flcaomrattiicoanl, (lmyimnpimhaolc)ytic (minimal) Tabular atrophy, cortical (intmal) HHeemmoopsoitdeesrtisn,pipgrmiemnatril(ysleigrhytt)hropoiesis (ainimal) Plasmacytosis (moderate) Plasmacytosis (moderate) NMToeessatebennsot/re2mr,ailcAidtLriyeemnshalfNooGudlnead.ndt/n:1, PAadncrreenaasl, GTleansdt/ezs,/1,Thymus, sdaaycsrifoifcetrgersomwepnt 1: necropsy status: 2t9eminal sacrifice planned terminal ddaattee ooff esntdarotfotfretartemaetnmte:nt:03/0161//1500/90 date of necropsy + 04/11/98 Wo findings noted HSIeinpnfagltlaoemcmacaletlloulrlyanerccarvloalsciusfo.olta(tsil(oisgnlhitg()hati)niral) Hematopoietic cell foi (minimal) Hyaline cast(s) (stnimal) 000356 PATHOLOGY REPORT Page 51/146 TTeesstt ASrytsitcelme:: TEExLpOlEoRraAtLoOrIyOL/2I0E-LDOaGyR GACaRvYaLgATeE/Study/eiins/eRraosts PNrOoTpOaKthno.mo.:+ 24923903130 Sponsor 3M Toxicology Services Date : 212pr.1999 Individual Animal Data Records . sAenxi:mal wor a7 te DosE Group: Vehicle Cantzol H(ccoRnotsincioepd)c FmIIGS Spleen Animal wo: 8 McRoscoprc FwmiGs MrcRoscoprc Fmmics river Kidney/1 Kidnay/2 spleen . HHeemmoopsoiideesrtisn, pipgraiemnatril(yaienrimyatlh)ropoiesis (slight) N2To,esatTbhenyaom/rulms,a,liTteMsietesasesn/tf2eo,ruinAcddriLeny:nmaplhPaGNnolcdarsne,das/,iW,anKAdiddinrbeeuynl/aazlr, GLlyamnpdh/ Nodo/1, Mandibular Lymh Node/2. dsasycsrifoficetrgeraotmuepnt :: t29erminal sacrifice dnaetceroposfyssttarattusof treaitmpelnatn:ne0d6/t1e0r/m9i8nal ddaattee ooff nenedcroofpstyreatmen0t4:/110/39/811/98 No findings noted Inflammatory cell foot (slight) Tubular atrophy, cortical (minimal) Interstitial {nflamation, Lymphocytic (inimal) Hesopotesis, prisarily erythropolesis (sinimal) NM`oeTesssehtnmetoser/r2m,iaclAidtLryiemenpsahlfNooGudlnead,ndi/Mnl:a,ndPAiadbnrucerlenaaarsl,LyGTlueapsnhdt/eN2so,/dle,/T1h,ymis, Mandibular Lymph Node/2. 000357 PATHOLOGY REPORT TTeesstt ASrytsitcelme:: TEexipsleonrAaLtCoOrHyOL2/T0T-LDOaNyRAGCaYvIaAgTeE/Study/eriins/Rerasts Sponsor + 3M Toxicology Services Page 52/146 PNrOoTpOaXthmo.no. 24929003130 Date. : 21.2pr.1955 Individual Animal Data Records - sAnxt:mal ve: a9te : DOSE Gaoup: Vendele Control MacRoscorte FnmINGS Sdaaycsrifoifcetregartomwenc naccopsy status +: r2e9covery group i planed recovery ddaattee ooff astnadrtofoftretartemaetnmte:nt:03/0161//1500/30 date of neczopsy 16/11/38 sun chest region: Alopecta Moisasbuneosrmsaxlaitniiensedwere found in any of the other MrcRoscopre FnmINGs Liver Influmatory cell fol (slight) No abnormalities found in: Pancreas. ) MACROSCOPIC FnwINGS : MrcRoscoprc FnmINGS sdaaycsrifoficetrgeratomuenpt:: r2e9covery grou dnaetceroposfystsatrtaotfutsre:atmpelnatn:ned06r/e1c0/o3v9ery ddaattee ooff neencdroopfstyreatm|:en1t8:/110/39/811/90 No findings noted Liver sIinnfgllaemmcaetlolryneccerlolsifsoot(sl(imgohdte)zate) No abnormalities found in: Pancreas. 000358 PATHOLOGY REPORT Page 53/146 TTeesstt ASrytsitcelme:: TEExLpHlEoRraAtLCoOrHyOL/2T8E-LDCWaEyR GACaRvYaLgATeE)Stud/yeRiisn/eRraosts PNrOoTpOaXthmo.no.:+ 25452091303 Sponsor: 3 Toxicology Services Date + 212.1999 Individual Animal Data Records sAenxi:mal ve: H1alo DOSE GROUP: Vehicle Cantrol MACROSCOPIC FINDINGS sdaaycszifoifcstrGeraotmwepnt : : meczopay status: 29 rpleacnonveedryregcroovwery ddaattee ooff setnadrtofoftretartemaetnmte:nt:03/0161//1900/9 date of necropsy 28/11/38 No findings noted MICROSCOPIC FINDINGS iver sIimnfgllaemacteolrlyneccerllosifsoel(mi(nsilmiaglh)t) Hepatocellular vacuolation (minizal) No amormalities found in: Pancreas. Aotmal vo: 13 MACROSCOPIC FTIDINGS dsaaycsrifoifcetrgeraowtpment:: r29ecovery group 2 dnaetceroopfsystsatrtaotfutsre:atmpelnatn:ne0d6/r1e0c/o9v8ery 2 ddaattee ooff neencdroopfstyreatmen0t2:/120/39/811/98 No findings noted - McRoscopTC PIOINGS Liver sIinnfgllaemmcaetlolryneccerlolsifsoc(si(nsiimgahl)t) Hepatocellular vacuolation (minimal) No amomalities found in: Pancreas. 000359 PATHOLOGY REPORT Page 54/146 TTeesstt ASrytsitcelne:: TExepilonraAtLCoCrHyOL/2T6E-LDCaHEyR GAaKvLaAgTeE/Study/erisn/eRroasts PNrOoTpOaKthno.no.: 24923503130 Sponsor i 3 Toxicology Services Date. 21.2pz.1999 Tndividual Animal Data Records Asetx:ma bo: r1a4te DOSE GRovP: Vehicle Control Macroscopic FnwmIGS dsaaycsrifoifcstregartmoenut p: neceopsy status i r29ecovery group 2 plumed recovers 2 dddaaattteee ooff of nesetncadrreoopfsotfyrteraetam+tsmn0ec2n:/t1:26/39/08161//1300/58 - No findings noted MrcRoscoprc FnmINGS Liver ISinnfgllaemmcaetlolryneccerllosifsoct(ai(nsilmiaglh)t) No abnormalities found tn: Pancreas. ratmal No: 15 Mcroscopre FnomIGs sdaaycsrifoifcetrgeratomuenpt:: r29ecovery grow 2 dnaecceropofsy cate of setnsadtrotafotfturetsaret:amtemnpetln:atn:n0e30d/61/1r1/e09c/8o9v8ery 2 cate of necropsy |: 02/12/58 i Mrcroscopre FomiGs No findings noted ver Pancreas Inflammatory cell foci (slight) Mpoptosts/single cell necrosis, exocrine (ninimal) 000360 `PATHOLOGY REPORT Page 5/146 TTeesstt ASrytsitcelme:: TErxpileorraAtCoCrHyOL/2T8E-LDOaWyR GAaCRvUaAgTeE/Study/eriins/eFraosts PKrOoTpOaKthno.no.: 2s4s2001303 Sponsor i 3M Toxicology Services Date. : 21.2pr.1s99 Individual Animal Data Records : seAxt:ma wor F97easle DOSE Group: Vanicle Control MACROSCOPIC PIOTNGS `Macroscopre PrmmIGS ver. Kidney/1 Spleen Aatmal vo: 98 croscoptc FrwmiGs onstes dsaaycsrifoifcetregarcmoenutp:: 2t9eminal sacrifice dnaetcacoposfystsatrattusof treaitmpelnatn:ned00/t1a0m/m9i8nal ddaattee ooff neencdroopfstyreatmen0t5:/110/49/011/30 Yo findings noted ISinnfgllaemmcaetlolryneccerllosiFsock(ai(nstlaiaglh)t) Tubular atrophy, cortical (atntmal) HHeemmoopsoitdaesrtisn,ppircimmeantril(ysoedrezyatther)opoiesis (ainimal) NTOohvyaamrbiyna/o,ir,mNaelOvisatezinyet/se2x,fiocAudnlrdyeznpianh:lNGoPdlaean,ncdr/eMlaa,sn,dAidKbriuedlnnaearyl/L2Gy,imapnhd/2, Node/1; Mandibular Lymph Wode/2. Sdaaycsrifofictergeraatpment:: t20aminal sacrifice dnaetcecoposfystsatrtaotfutsre:atmpelnatn:ned06t/1e0r/m9i8nal ddaattea ooff neencdroopfsytreatmen0t5:/110/49/811/93 Lett side Wacery cyst Niosasbuneosrmaelxiatmiiensedwere found in sny of the other 000361 `PATHOLOGY REPORT Page 36/146 TTeesatt ASrytsitcelme:: TEHxLpOlGoRraAtLoCrOyIL/2T8E-LDOaWyR AGaRvLaAgTeL/Study/emiins/Rioasts PNrOoTpOaXthmo.no.: 24923003130 Sponsor: 3M Toxicology Services Date. + 21.pr.1995 Individual Animal Data Records seaxt:m vor F0easle DOSE GRoup: Vehicle Control McRoscoprc FrmGS ver Pancreas Kidney/1 onzyn Spleen Mnteal or 99 MACROSCOPIC FTIDINGS MrcRoscopre FrmINGS Liver. Pancreas Spleen Inflammatory cell foct (ntninal) Apoptosis/stngle cell necrosis, exocrine (sintsal) Pelvic ntneralization (ainial) No miczo correlate HHeemmoopsoitdeasrtisn,pipgrmiesnatril(ysleirghytt)hropoiesis (nintaal) NAModecsaeebnnnatolerrmiaGcllaintLdiy/erlsp,hfANoodudrneed,naiMnl:anGdlKaiinmddnu/elZya,/k2,TLhyysomvpiahss,yN/o2d,e/1, Mandibular Lymph Node/2. sdaiycsrifoifcetrgeartmoenutp:12t0erminal sacrifice dnaetceropofsystsatrtaotfutsre;atmpelnatn:ne0d8/t1e0r/m9i8nal ddaattee ooff neencdroofpstyreatm|:en0t5:/110/43/811/30 No findings noted ISinnfgllaemmcaetiolryneccerlolsifsoct(mi(nsilsiagdh)t) Apoptosis/stogle cell necrosis, exocrine (mintaal) HBeemmoopseitdeesriisn,ppirgiaemnatcil(y11e6ry%t)hropoiesis (ainimal) NhOovyaamzbysn/o,Lr,maMleOivstaezinyet/se2r,ifcoAudnLrdyemnpisnh:lNoGKdliead,snde/yMl/a,1n,dAibrKuieldnnaaerly/L2Gy,imapnhd/z, Node/1, Mandibular Lymph Node/2. 000362 `PATHOLOGY REPORT nage 57/146 TTeesstt ASrytsitcelme:: ETxepilonraAtCoOrHOyL/2T0E-IDOaGyR GAaCRvYaAgTeE/Stud/yeRiisn/eRrcasts PNrOoTpOaKthRo.ho.: 2432091303 Sponsor + 3M Toxicology Services Date. 21.apr.1999 Individual Animal Data Records N seAxnt:al No: F1e0m0ale DOSE GROUP: Vehicle Control McROSCOPIC PIIDINGS acaoscorte FDIS Liver Kidney/1 Spleen Animal Nor 101 sacaoscorre FIGS . ndSeaacycrsroipofsfiycetsrtgearatitosmuenpt::i t20erminal sacrifice planed terminal ddaatcee ooff esntdartofoftretartemaetnmte:nt:040/011//1300/98 date of neczopsy : 05/11/98 No findings noted ISinnfgllaemmcaetiolryneccezlolsifsool(mi(nmiimnailm)al) Tubular atzophy, cortical (aintmal) HHeammoospiodtaarsitns',pipgrimmeanctil(ys1e4grhytt)hzopodesis (ainimal) NOovaarbyn/oLr,maloviatziye/s2,foAudnrdenian:l PGlaanncdr/ela,s,AKriednnaely/2G,land/2, NTohydmei/s1,; `WMaensdeinbtuelraizc LLyyempphh NNooddee,/2.Mandibular Lymph Saaycsrifoifcetrgeraoutpment: t20eminal sacrifice dnaetceroposfystsatrtaotfutsre:atmpelnatn:ed00t/e10r/m9i0nal caattee ooff neencdroopfsytreatm+en0t/:110/53/811/90 Yo findings noted 000363 PATHOLOGY REPORT Page 58/146 TTeesstt ASrytsitcelme::TrExipalmonrNaCtOoKrHyOL2/T6E-LDGaGyA GAaYvIaAgTeL/Study/PRiinS/PRRa0sts PNrOoTpOaXthno.no.: 20929003130 Sponsor + 3M Toxicology Services Date + 2lapr.198s Individual Animal Data Records tExm:l ver r1e0n1sle DOSE GROUP: Vehicle Control MacRoscorte FIIDINGS Liver Kidney/1 Spleen MaTndibular Lymph Nods/ Atma wo: 102 MacRoscoPTe FINDINGS MrcRoscopre FIGS ver Kdney/1 Spleen . ISinnfgllaemmcateolryneccerlolsifsool(mi(nsilmiaglh)t) Tubular mineralization (minimal) Homosiderin pigment (acderate) Iysphoid hyperplasia (slight) NoOvaarbyn/oir,maloivtaziye/s2,foMuned ainl: GPlaanncdr/ela,s,AdKriednneayl/2G,iand/2, TNhoydmei/s2,. Nesenteric Lymph Node, Mandibular Lysph dSaaycsriofficetrgeraocumpent : 2t9erminal sacrifice ndaetceropofsystsatztaotfutsre:atzpalnatn:ne0d8/t1e0r/m9i8nal ddaaccee ooff ennedcorfotprseyst:asn0t6:/1015//9181/99 No findings noted ISinnfgllaemmcaetlolryneccerlolsifsoci(ai(nstlmiaglh)t) Tubular atrophy, cortical (intmal) HHeemmoospiodteersiins',pipgrmiemnatril(yaoedreyratther)opolests (aintmal) YOovaacbyn/o1r,malOviatriye/s2,foAudnrdenian:l PGlaanncdr/e1a,s,AdKriednneayl/2G,land/z, hNoydmei/s1,, MMeasnednitbeurliacr LLyymmpphh NNooddee,/2.Nandtbulas Lysgh 000364 `PATHOLOGY REPORT rage 59/145 TTeesstt ASrytsitcelme:: TErxpiloonraAtLoCOrHyOL2/8T-ILDOaGyA GACaRvYaLgKTeE/Study/emiins/eRracsts PNrOoTpOaXthno.no.: 24925003130 Sponsor + 3M Toxicology Services Date. + 21.apr.199 Individual Animal Data Records oSxt:al vor 1F0e3msle DOSE GROUP: Vehicle Control cRoscopc FomIIGs dsaagcsrifofictergeraotpment:: 2t9eminal sacrifice ndaetceropOsfystsatrtatofutsre:atmpelnatn:ned08/t1e0r/m3i8nal . ddaattee ooff ennedcroofpeytreatm|:en0t6:/101/59/011/50 Yo findings noted Mrcroscorze FIGs Liver ISinnfgllaemmacetlolryneccerlolsifsoc(st(nsilziaglh)t) spleen HHeemmoopsoitdeesriisn,pipgrmiemnatril(ysliegrhytt)hropoiesis (atatmal) Thymus Lymphotd atrophy - involution (minimal) Animal wor 104 MKoidanbenyo/r2m,alOivtaizeys/lf,ouOnvdaziyn/:2,PaAncdrreeansa,l GKliadnnde/y1/,l, ALdycmepnhalNodGel/a1n,d/2M,andMiebsuelnaterrLiycmLpyhmNpohdeN/o2d.e, Mandibular MACROSCOPIC PIDINGS dsaaycsriofficatrgeraoutpment:: t2e9rminal sacrifice dnaecceroopfsystsatrtaotfutsre:atmpelnatn:ed00/t1e0r/m9i8nal "daattee ooff neencdxoopfsytreatm|:en0t6s/110/59/811/98 Wo findings noted 000365 PATHOLOGY REPORT TTeesatt ASrytsitcelme::TeEixpolmoarAaLtOoHrOyL/2T6E-LDOaMyR GAaCRvIaAgTeE/Study/oRiinS/eRiaosts Sponsor + 3M Toxicology Services nage 60/145 PNrOoTpOaKthno.ne.:i 24925903130 Date : 21.apr.1s99 Individual Animal Data Records Asetx:ma wor F1e0m0ale DOSE GROUP: Vehicle Control MacRoscorte FIINGS Liver aney/1 Spleen retmal Wor 105 MACROSCOPIC FIDINGS skin MrcRoscopre FromIGS ver skin . ISHoinpnfagltlaoemcmeacltelloulrlyancreecvlralocsuifssolcal(vsit(onainimnat(las)ailn)tsal) Tubular atrophy, cortical (atntmal) HHeemmoopsoitdeesrtisn,piporinmeanrtil(y31eigrhyet)hropoiesis (aintmal) NOovaazbyn/o1m,malOdvatriye/s2,foAudnrdenian:l GPlaanncdr/ela,s,AdKriednnaely/2G,land/2, TNhoydmei/s1,, MMaensdeinituelrairc LLyymmpphh NNooddee,/2.Mandibular Lymph dSaaycsrifoficteregartowmpent : necropsy status: r29ecovery group planned recovery ddaattee ooff setnadrotfotfretartemaetnmte:nt:05/0181//1903/98 dace of neczopsy : 20/11/98 abdominal regicn: Scab formation Niosasbuneosrmaelxiatmiiensedwere found in any of the other ISinnfgllaemmacatlolryneccerlolsifsoci(si(nstlaiaglh)t) I`nGfRloasmsmattiinoani,ng)exudative (slight) (correlates to 000366 samHoLoGY Favor nage 61/146 TTeesstt ASrytsitcelme:i iExopleoraatcoorwyoL2i6t-iDoanys GAacvtaagTee/Stud/yemian/erRoasts PNrOoTpOaKthmo.mo. 2905903130 Sponsor + 4 Toxicology Services Date i 21aprises Individual Animal Data Records asDnomisemtalGrovvere: V1Pa0em6nineilee Control wcrosconc moms acRoscorte prmmiGs saver angel wor 107 Macrosconte pics ) rcrosconc roms Liver animal wor 109 xacroscorte romiGs dSSaeiyccsrioropifscysczsgetraatotimusepns |: rl29eacomveeryregcroovwery GGtiatteae SOCEFF nsaetncaterooefpeoyfCrearteod+acnh2ea0:n/c1:10//901801//3900/58 wo findings noted HISiennpfgalltaeomcaceclaollrulylanreccervlolascifusooclta(tsii(onsnt1m4ag(lhs)el)ight) RaSeayccsreoifpoisfcyecsrgteartsouwcsent:|1 r2e9covery grow planned recovery aGGaattSaae Soofft anstxeadcr"torrooCfprsetynrte:maucnb2te0sn/t1:10/55/08181//1000/00 Wo findings noted Inflammatory cell foct (s1ighe) asaycsriofficecgrreoaump:: r2e9covery group 2 GdDaeetcaecoCopEfaySansAdtEoafotfCureessxto:msacnhptalsnatn:0e5d/0181r//3e50c0/o3v8ery 2 ace of necropsy + 04/12/58 000367 `PATHOLOGY REPORT rage 62/146 TTeesstt ASrytsitcelme:: TExEpLloEraAtLoOWrOyL/2T8E-IODHaIyA GACaRvYaLgATeE)Stud/yoriisn/eRroasts PNrOoTpOaKthmo.no.:+ 24529903130 Sponsor + 3M Toxicology Services Date : 21.2pr.1999 Individual Antmal Data Records tSuae:al wor F1e09male DosE Grove: Vehicle Control c(RcoonStCiOmPiIedC FTIDINGS acroscorze FrmmGs ver atm wo: 120 acRoscorze FnmmGs MrcRoscorte FmmINGS ver Aatmal we: 11 McaoscoRre FIDDGS sacaoscorre FrmmGs ver . No findings noted SIinnfgllaemacteolrlyneccarlolsifsoct(ai(nstimgahlt)) dsaaycseifoifcetrgearmoenutp:: 2r9ecovery growp 2 ndaetcecoposfystsatrtaotfutsre:atmpelnatn:ne0d8/r1e0c/o9v8ery 2 ddaattee ooff neencdroofpsytreatm+en0t4:/120/53/811/98 No findings noted aflamatory cell foot (slight) dnsaeiyccsrroipfosfiyctersegtartamoetnuutps::: 2r9ecovery group 2 planned recovery 2 ddaattee ooff estnadrtofotfretartemaetnmte:nt:050/81/11/09/898 date of necropsy + 04/12/98 No findings noted Inflammatory cell foot (minteal) 000368 PATHOLOGY REPORT Page 63/146 TTeesatt ASrytsitcelme:: TEexipclwEonzaAtLoCrOyL/2F6L-ODNaEyR GAaRYvIaAgTeE/Study[PriHnS/eRraosts NPrOoOpKathno.no.:+ 24523003130 Sponsor + 34 Toxicology Services Date : 21.apz.1999 Individual Animal Data Records asDneOtxS:mEalGrovvore: sT1ae7lleomer Aleshol cRoscopre FrDIIGS MacRoscoPre FIDINGS Liver Pancreas Kidney/1 Kidney/2 spleen Ma1ndibular Lymph Nods/ rtm No: 20 McRoscopre FrwmIGS . ndSaeayccsrroipfosfiycetsrgetraaotptmeunst::: pt2l8eamninneadltsearcmriinfailce ddaattee ooff esntdarotfotfrecartemaetnmte:nc:02/0161//1308/98 Gate of necropsy 03/11/50 No findings noted ISinnfgllaemmcaetlolryneccorllosifsool(ai(nmtienatls)al) Apoptosis/single cell necrosis, exocrine (slight) Tubular atrophy, cortical (slight) Tubular atzophy, cortical (minimal) Hemopotests, primarily erythropoiesis (atnizal) Plasmacytosis (slight) N`oMAedsarebennntoarelmraiGlcliantLdiy/em1sp,hfAoNdourdneed,nainMl:aGnlTdaeinsbdtu/elZsa/,r1,TLhyTymempishst,eHso/dze,/2. dSaaycsrifoifcetrgeraomuepnt t20erminal sacrifice Ganaetcceerooopffsysetnsadtrtoafotfturtesraet:amtemnpetln:atn:n0e20/d61/1t1/e03r/8m9i8nal aace of necropsy| 03/11/98 No findings noted 000369 PATHOLOGY REPORT Page 64/146 TTeesstt ASrytsitcelme:: ETxepilonraAtLCoOrHyOL/2T8E-LDOaWEyR GACaRvMaLgATeE/Stud(yRiISn/eRRaost's PNrOoTpOaXthmo.mo.:+ 24929903130 Sponsor + 3M Toxicology Services Date + 2Lapr.1sss Tadividual Animal Data Records 8 ADsnOeixSm:EalGROwUo:P: NT1ae8tleemer Alcohol MrcRoscoPIC FRING sive Pancreas Kdney/1 Kieney/2 Speen Ma1ndibular Tymgh Node/ antaal wo: 19 cRoscoRre FDIS MrcRoscoprc FnwmIGS Liver Spleen MIindfzloanmamlatcoernytrciellolbufloacrt h(yspiegrhttr)ophy, diffuse (minimal) Rooptosts/stogle cell necrosis, exocrine (minimal) TPeulbvuilcarmiatnreorpahlyi,zactoirotnic(amlini(maatln)tmal) Tubular atneralization (ainisal) HHeemzoospiodteersitns',ppirgiemnatril(ysienrimyatlh)ropolests (mintmal) Plasmacytosis (sederate) MoAdraebnnaolraaGlliantdi/els, fAodurnednailn: GTleasntde/s2/,1,ThyTmeisst,es/2, Mesenteric Lysph Node, Mandibular Lycph Node/2. dSaaycsriofficstrgearmeonutp:20terminal sacrifice ndaetceroopfsysstattaotfutsre:atmpelnatn:ne0d6/c1a0m/m9i8nal ddaattee ooff neencdroopfsytreatm+en0t3:/110/29/811/90 No findings noted MIindfzloanmamla/tcoernytrciollldbufloacri h(yipneiratarlo)phy, diffuse (intel) HHeemmoapsoitdeasriisn,pipgrmiemnatril(yaienriyastlh)ropoiesis (minimal) 000370 PATHOLOGY REPORT Page 63/146 TTeesstt ASrytsitcelme::TEHxpLlEorAaCtoCrHyOL2/0I-SDLaOyA GACaRvYaLgATeE,Stud/yerisn/erRoasts PNrOoTpOaKthmo.no.: 24929903130 Sponsor + 3H Toxicology Services Date 20.Apr.1999 Individual Animal Data Records : rSDOtESm:EalGRnUePr: a1T9elleomer Alcohol s(ccRonotsicmoiresd)e FINDINGS Mesenteric Lyaph Node MaTndibular Lyssh Node/ animal wo: 20 MacRoscoprc FTDINGS MrcRoscopIC FmDINGS Liver Pancreas Kidney/1 Spleen Congestion/erythrophagocytosts (atntal) Plassacytosts (slight) No`Airdaenbnonayo/lr2m,aGlliTatnaids/et2as,s/f1To,huynmTdiessi,tn:esM/aP2an,ndciArbeduarlsea,nralKLiyGdmlnpeahyn/dN1/o,id,e/2. dSaadyrsifoifcetrgeraotwment: 2t0aminal sacrifice nGaecceropofsystsatrtaotfutsr:eampalnacn:ne0d6t/e10r/m9i8nal dGaattee ooff neencdroopfsytreatm+en0t3:/101/23/811/98 No findtngs noted MISiindnfzglolanemamlactecolerlnytnrecicelrlolobsuiflsoacrk(shi(ynspilesiarglth)tr)ophy, diffuse (minipal) Apoptosts/single cell necrosis, exocrine (minimal) Tubular atrophy, cortical (minimal) HHeemmoopsoitceasriisn,ppirgimmeanrtil(ysleigrhytt)hropoiesis (minimal) NoTesatbenso/r2m,aliAtdireensalfoGulnadndi/n1:, KAiddnreeyn/a2l,GlTaensdt/e2s,/1,Thymis, HMaasnednitbeucliacr LLyymmpphh NNooddee,/2.Mandibular Lymph Node/1, . 000371 PATHOLOGY REPORT Page 66/148 Test Test Article: System : TEExLpolMEoRraAtLoCrOyHOL2/0T-EDLaGyR AGCaRvYaLgAeTEStud/yeTiiSn/eRroasts| NOPrToOpXatmho.no.:+ 20325003130 Sponsor 1 3M Toxicology Services Date. + 212x199 Individual Animal Data Pecords rsuox:ts yor a21le D0sk Group: Telemer Alcohol MACROSCOPIC PIIDTNGS croscopre FrDIGS ver Kidneys Kidnoy/2 Spleen MaTndibular ymph Node/ rote vor 22 MACROSCOPIC PDDINGS . dSaaycsriofficetrgeratomuenpt:: 2t9erminal sacrifice ndaatceropoafytsacttaotfutsre:acpmelnatn:ned06t/e1r0/m9i8nal Gdaattee ooff snencdzoofpstyreatmen0t4:/110/39/811/98 No finatngs noted MSIiinndfgzlloaenmamlac/tecloelrnytnzecicollrloobsuiflsoacr(mhi(ynspilemiraghtlt)r)ophy, diffuse (minimal) BIynatleirnsetitciaastl(si)nfl(uatmnaitniaoln), lymphocytic (Rintmal) TIunbtuerlsatritaitarlophiyn,flacmomrattiicoanl, (layimnptnhaolc)ytic (atntsal) HHeemnoospiodteersitns',pipgrmiemnatril(ynienriymatlh)ropoiesis (aintnal) Plasmacytosts (slicht) NM`oTeesasebtnretosre/mr2,ailcdAtdLiryeemsnpahlfNooGudlnead,ndi/nMl:a,nPdAaidnbcrurelenaaarsl,LGylsTaegnshdt/eN2so,/dle,/n2y. m, dsaaycsrifoifcetrgeraowtpment:: 2t9eminal sacrifice dndaaettceerooopffsyestnsadtrtoafotfturetsarte:maetnmptel:natn:0n3e/0d161/t/1e30m/8i9n8al date of neczopsy : 04/11/58 000372 `PATHOLOGY REPORT TTeesstt ASrytsitcelme:: TExrpilonraAtCoOrIyOL2T-ELDOaEyA GAaRvAagTeEStud/yPRiISn/PRroasts Sponsor + 3M Toxicology Services - Page 67/146 PNrOoTpOaXthno.no.: 24523903130 Date + 21.Apr.2099 Individual Animal Data Records . osetxa: l No DOSE Group: 2aT2elleomer Alcohol M(accoanotsicnuoepdr)c nimTNGS No findings noted `Mcaoscoprc FDINGS { iver Pancreas Kdney/1 Kidnoy/2 Spleen SMIiinndfgilloaenmamlac/teclolraynntecrceilrlloasbiafsolcais(mhi(ynspilzeiasgleh)tr)ophy, diffuse (slight) Nooptosta/single call necrosis, exocrine (sight) Tubular atrophy, cortical (minimal) Tubular atrophy, cortical (atninal) HHeemmoopioiideesrtisn,ppirgimmeantril(yzienirsyatlh)ropoiesis (slight) N`oMAedsacebennnotarelmraGillciantLdiy/em1sp,hfAoNduornded,nainMl:anGdlTaiensbdtu/el2sa,/rl,TLhyyTsmepishst,eNso/dze,/1, Mandibular Lymph Node/2. antaal wer 23 MACROSCOPIC PDDINGS . dSaaycsrifoifcetrgeraoutpment:: Decropay stacis p2t9leamninneadl tsearcmriniaflice GGaattea ooff ssntdartofoftrteartemaetnmte:nt:03/0161//1900/98 Gate of necropsy |: 04/11/58 No findings noted 000373 PATHOLOGY REPORT Page 68/146 TTeesstt ASrytsitcelme:: ETxepolmoaraAtLoOrHyOL2/0E-IDOaEyR GACaKvIaAgTeE/Stud/eymiisn/erRoasts Sponsor t 3M Toxicology Services PNrOoTpOaXtmho.no.i Date t 21.ape2.49129990931930 - Individual Animal Data Records . rsDeOtxSm:EalRoNou:: a23le Telemer Alcohol MicRoscopIc FIGS Liver Pancreas Spleen Ma1ndibular Lymph Yode/ Jatmal Nor 24 MACROSCOPIC FIDIIGS Macroscoptc FIIDINGS Liver Pancreas Spleen . ISinnfgllaemmcaetlolryneccerllosifsoot(mi(nsilmiaglht)) Apoptosta/single cell necrosis, exocrine (minimal) HHeemsoc3piodtaersitns',pipgrniemnatril(yaienrizyatlh)ropoiesis (sintmal) Plasmacytosts (slight) No`2T,aasb"tTnehosys/mlai,xs,liTNtaesitesasesn/tf2ao,ruinAeddciLeny:nsapKlhidGNnoledayen/,d1/,iM,anKAiddirnbeeunyla/azlr, GLlyamnpdh/ Nodes. dn faaycseoy opfsytsraetiaaotntmeunst::2pp9liaanmneeddttemoimnialna GGaattee ooff satnadrtofoftrecartemaetnmte:nt:03/0161//1308/98 Gate of necropsy 04/11/38 No findings noted MSIiindnfzglolanemamlactefolclreynntececeirllolosmifusolcat(mhi(ynspiiemgarhlet)r)ophy, diffuse (ainda) NEpxoocproisnies/astixnogplhye,cefloclanlec(raonsiimsa,l)exocrine (minimal) HHeemnocpsoitdeesrtisn,pipgrimmeanrtil(yaienirnyatlh)ropoiesis (Ligh) 000374 `PATHOLOGY REPORT Page 63/146 TTeesstt ASrytsitcelme:: TEexLpolwoaraAtGoOrHyOL/2T0E-LDOaGyR GACaRvVaLgATeE/Study/emiins/eRroasts PNrOoTpOaXtmho.no.: 24325003130 Sponsor i 3M Toxicology Services Date. + 21.pr.1598 Individual Animal Data Records - ASDaeOtxSm:EalGRNUoP:: a2T0etleomer Alcshol ; (accoRnotsicnuoepdz)e FIIDNGS Ma1ndibular Tysph Node/ Plasmacytosis (slight) NoResatbensosrsm,aliTtesiteess/f3o,unAddrien:nalKiGdlneayn/dl/,l,KAidrneenya/2l, Gland/ 2N,odeT/hZy.m3, Mesenteric Lymph Node, Mandibular Lymph atm Nor 25 acroscoprc FwmiGs dSaaycsrifoficetrgeraatpment:i 2f9ecovery group eGcatieopoafyssttaarttusof treatmpelnatn:ed06/r1e0c/o3v8ery adatcee ooff neencdzoafpsytreatm|:en1t8:/110/33/811/98 No findings noted MacRoscoprc FmmINGS ver ISnifnlgalmemacteollryneccerlolsifsool(si(nstlaiaglh)t) Hematopoietic cell foci (minimal) No abnormalities found in: Pancreas. : atau wor 26 MACROSCOPIC FIIDINGS dSaaycsrifoifcetrgeraomuepnt :+ 2r9ecovery group nGaetceroopfsystsatrtaotfutsre:atmpelnatn:ned06/r1e0c/o9v8ery ddaattee ooff nenedcorfoptrseyat:men1t6:/101/35/811/98 No findings noted 000375 `PATHOLOGY REPORT rage 70/148 TTeesstt ASrytsitcelme:: ETxepilonraAtCoOrHOyL/2T8E-LDOaEyR GMaRvaAge)Stud/yoRiisn/eRioasts PNrOoTpOaXthmo.no.: 24529903130 Sponsor + 3W Toxicology Services Date + 20Ape.1999 Individual Animal Data Records Saanxt:aal wo: s2a6le DoS Gove: Telamer Alcohol MicRoscoPze FINDINGS Laver rntmal wer 27 caoscorre FnmnGs Testes Macaoscopre FINDINGS ver : Pancreas - Testea1 Testess2 MISiindnfzglolanemaalct/eoclrelyntneecicorllolasbiufsloacsi(mhi(ynspioezdareltr)raotep)hy, diffuse (animal) No abnormalities found fn: Pancreas. dSaaycsrifoifcetrgeraoutpment:i Daccopsy status: r29ecovery grow planned recovery ddaattee ooff sentdatofotfretartemaetnmte:nt:030/61/1/1900/38 cate of necropsy |: 16/11/38 Reduced tn size PLACID Niosasbuneosrmaelxiatmiiensedvere found in any of the other SIinnfgllaemmacteollryneccerllostfsoct(si(nstomdaelr)ate) 2xocrine atrophy, focal (animal) SeGmat0nsisterionudsingt)ubular atrophy (severe) (correlates to S`eGmRionsisferinoduisngt)usilar atrophy (severe) (correlates to 000376 `PATHOLOGY REPORT nage 71/146 TTeesstt ASrytsitcelme:: TExepilonraAtCoOrHyOL/2T8E-LDOaEyR GAaRYvIaAgTeE/Study/eriins/eRracsts PNrOoTpOaXthno.no.: 24923003130 Sponsor 3M Toxicology Services Date. 212pr.1999 Todividual Animal Data Records - rseax:ta we: a29le DOSE Grove: Telomer Alcohol MacRoscoste FrmmNGs Macaoscorte FrmmNGs Liver Rtas wor 30 McRoscoprc FnwINGS Mxcroscopc Frwmics Liver sdaacyrsifoifcetrgeratomuenpt:: Racropsy status: rp2e9lcuomveedrysegcroovuer2y 2 ddaattee ooff estnadrtofoftretartemaetnmte:nt:03/0161//150815 date of neczopsy : 02/12/98 No findings noted MIindfzloanmamlatcoernytrciellolbufloaotr h(yspleirgthrto)phy, diffuse (minimal) No abnormalities found in: Pancress. saaycsrifoifcetrgeratomuenpt:: r29ecovery grow 2 dRaetceropofsystsatrtaotfutsre:atmpelnatm:ne0d6/r1e0c/o9v8ery 2 ddaattee ooff neencdzoopfsytreatm+en0t2:/120/39/811/90 No findtngs noted ICSionnafgglluaelmamctaeitlvolerynneecccerzlolossiifsso,ot(fmoi(cnsaillmiaglh()tm)inimal) No abnormalities found in: Pancreas. 000377 PATHOLOGY REPORT Page 72/148 TTeesstt ASrytsitcelme:: TExEpLloEraAtLoCOrHyOL2/0I-TIDOaEyR GACaRvYaIgATeE/Stud/yRRiiSn/tRroasts PNrOoTpOaKthmo.ho.:i 25452001303 Sponsor i 3M Toxicology Services Date. t 21pr.1598 Individual Animal Data Records Asetx:ma vor a31te DOSE GROUP: Telomer Alcohol McRoscoprC FLIDINGS sdaaycsrifoficetrgesrmeontw:1 r29ecovery grow 2 naGeatcceeropoosffyesnstdatrotafotfturtesraet:smtemnpatln:atn:n0e30/d61/1r1/e03c/0o3v8ery 2 ace of neczopsy| 02/12/98 No findings noted Mcaoscopre Fries ver ISinnfgllaemmcaetlolryneccerllosifsoct(ai(nstlmiaglh)t) No abnormalicies found n: Pancreas. Msuoxt:el wer T1e1m3sle MACROSCOPIC PIDINGS sdaaycsrifoifcetrgeraowtpment:: t20eainal sacrifice dnaetceropofsystsatrtaotfutsre:atmpelnatn:ne0d8/t1e0r/m9i8nal ddaactee ooff neencdroofpstyreatm+en0t5:/110/49/811/98 . No findings noted Mrcaoscoprc FrwmGs Liver Spleen Ma1ndibular Zysph Nods/ SIinnfgllaesmcaetlolryneccerlolsifsoci(i(nstlaiaglh)t) HHeemzoospiodleersitns',pipgrimmeanrtil(ys1e4rGyht)hropoiesis (ainiaal) LPylrapshmoaicdythoyspiesrp(lsalsiigah.t)(slight) 000378 `PATHOLOGY ReRoRT rage 73/146 TTeesstt ASrytsitcelme::TEHxLpHlEoMrAaLtCoOrHyOL2/T8E-LDOaGyR GAaCRvYaLgAeTEStud/yePiisn/eRroasts PNrOoTpOaKtnho.ho.: 20523003130 Sponsor + 3M Toxicology Services Date. : 21.2pr.1sss Individual Animal Data Records saaDnxOtS;mEalGRwOeU:P: T1F1ee3mlaelmeer Alcohol M(rccoanotsicnuoepdr)c FnDMIGS rotmal wor 114 MacRoscopte FrDTIGS . MICROSCOPIC FTIDINGS Liver Spleen Ma1ndibular Iyegh Yode/ - NKoidanbenyo/r2m,aliOtviareys/lf,ouOnvdariyn/:2,PaAncdrceeansa,l KGliadnnde/yL/,1, AMarnedniablulaGrlanLdy/m2p,h TNhoydmei/s2,. Mesenteric Lysph Node, dSaaycsrifoifcetrgeraowtpment: t20eminal sacrifice mdeacceroposfystsatrattusof treaitmpalnatn:ne0d8/c1a0m/i9n8al daaaccee ooff ennedcroofpsytreatmen0t5:/110/49/011/38 Yo findings noted ISinnfgllaemmcaotlolryneccerlolsifsoct(mi(nsilmiaglh)t) H`Heammoopsoitdeasriisn,ppirgiameantril(ysleirghytt)hropoiesis (minimal) Plasmacytosis (slight) NAKoiddranebennyao/lr2a,sGlliOatvniadr/ey2s/,lf,oyumonivdaszi,yn/:2M,ePasAnecdnrrteeeanrsai,lc GKLliyadsnnpdeh/yL/N,1o,de, Mandibular Lymph Node/2. 000379 `PATHOLOGY REsORE Page 74/148 TTeesstt ASrytsitcelme:: ETxepelnoaAtLoCrCHyOL2/8T-ELDHaEyR GACaRvYaLgATeE)Stud/yPSi/nERROaSts PNrOoTpOaXthno.no.: 21929003130 Sponsor: 3M Toxicology Services Date + 21.apri1995 Individual Animal Data Records seanxi:mal ve: 1F1e5male DOSE Group: Telomes Alcshol MAcRoscopIC FrIDINGS `McRoscoprc FING Liver Spleen Animal No: 116 MacRoscopre FIGS : McRoscopIC FINDINGS. Liver spleen . aSaycsrifoifcetrgeraowtpment:: 2t8aminal sacrifice ndaetceroposfystsatrtaotfutsre:atmpelnatn:ed08/t1e0r/m5i8nal ddaatcee ooff naencdzoopfsytreatmen0t5:/10/49/811/58 Yo findtngs noted Inflammatory coll foct (inal) HHeenmoopsoitdeesrtisn,pipgraiemnatr.il(ysleirghytt)hropoiesis (minimal) NoKidanberyo/s2m,aliOtviareys/lf,ouOnvdaciny:/2,PaAncdrzeeansa,i GKliadonde/yl/,l, AMdarnedniablulGalranTdy/e2p,h NThoydmei/s1,, MMeasnednitbeurliacr LLyysspghh NNooddee,/2. dnSaeayccsrroiofpfiscyetsrgetraatotmueunpst::: p2tl0eamninneadltsearcmriinfailce ddaattee'ooff setnadztofoftrteartemaetnmte:nt:040/181//1908/38 date of necropsy |: 05/11/38 Yo findings noted ISinnfgllaemmacetlolryneccerlolsifsoot(ai(naitanatla)al) HHeemmoopsoitdeesstisn,pipgraiemnatril(ysleirghytt)hropotesis (minimal) 000380 `PATHOLOGY RERORT rage 75/146 TTeesatt ASrytsitcelme:: ETxepalmosraAtLoCOrHyOL2/8T-ELDOaGyR GACaRvYaLgITeE/Study/EEiSn/eRroasts PNrOoTpOaKthno.ho.: 24523003130 Sponsor t 3M Toxicology Services Date. + 20apr.199s Individual Animal Data Records eDsOutxS:EmGRowuoRr: 1FT1ee6mlaelmeer Alcohol M(iccorntoiszcuoepd)e FrwIGS Atmel Wor 117 croscopze Frcs Kidneys KacRoscopte FDIS ver Kidney/2 Adrenal Gland/1 Spleen . NoKidanbenyo/r2s,sliOtviareys/lf,ounOvdariyn/:2,PanMcrreenaas,l GKliadnnde/yL/,1, MMaznednisblulGalranTdy/m2p,h TNhoydmai/s1,, MMeasnednitbeurliacr LLyymmphh NNeoddse,/2. aSaycsrifoficetrgeartomewnt:: t28aminal sacrifice nGaecceropofsysstattatofutsre:atmpelnatn:ne0d0/t1e0r/m9i0nal ddaattee ooff enencdzoopfstyreatm+en0t6:/110/59/811/38 right side Pelvic dilation Nossaubneosrmaelxiatmiiensedvere found in any of the other Inflammatory call foci (minimal) PeTlivndiicngd)ilation present (correlates to GROSS Extracapsular nodule present Haemmoospiodteerstisn,pipgrmiemnatril(ysleigrhytt)hropoesis (minimal) N`oOvaabsnyo/ir,malGviatziye/s2,foAudnrdenian:l PGalnacnrde/a3s,, TKhiydsnse,y/1, MMeasnednitbeurliacr LLyymmpphh NNooddee,/2.Mandibular Lyzph Node/1, 000381 PATHOLOGY REPORT Page 76/148 TTeesstt ASrytsitcelme:: ETxrpiloaraAtCoOrWyL/2A0T-IDOaGyR GAaRvaIgAeTStud/yeRiiSn/pRroasts PNrOoTpOaKthno.no.:: 20929003130 Sponsor + 3M Toxicology Services Date + 21.ape.1999 Individual Animal Data Records sFeaxtma wo: OSE GROUP: F1e1m8ale Telomer Alcohol MACROSCOPIC FIIDTNGS MrcRoscosic FIDINGS Liver. Spleen Thymus Ma1ndibular yh Nods/ Antal vor. 119 IcRoscorte FDIS > . dSaaycsrifoifcetrgescrmeontw:: 2t9erminal sacrifice nGaaettceeropoosffysstnsadtrtoafotfturetsarte:maetpnmtle:natn:n0e5d/0101/t/1a90m8/m9i8nal dace of mectopsy + 06/13/38 No findings noted SIinnfgllaemmactelolryneccerllosifsoci(ai(nitnatanla)l) HHeosmoopsoitdeesrtisn,pipgrmiemnatril(ysleigrhytt)hropoiesis (sinimal) Lymphoid atzophy - involution (minimal) Plasmacytosis (moderate) NKoidanbenyo/s2m,aldOtviareys/lf,ouOnvdariyn/:2,PaAndcrreenaasl,. KGliadnnde/y1/,l, ALdyrmepnhalNodGel/a2n.d/2, Mesenteric Lymph Node, Mandibular aSaycsrifoifcecregarmomwepnc +: 2t9erinal sacrifice PGeaccecoposfysstatrtaotfutsre:atmpelnatn:ned08t/e1r0m/i5n8al Gdaattee ooff ennedcroofpstyr|eatmen0t/s110/53/811/90 No findings noted 000382 `PATHOLOGY REPORT Page 77/148 TToesstt ASrytsitcelme:: TExepulonraAtLCoOrHyOL/2T0E-LDOaHEyR GAaRvYaLgAeE/Stud/yRiiSn/pREcasts PNrOoTpOaXthmo.no.: 24923803130 Sponsor + 3M Toxicology Services Date t 21pr.a99s Individsal Animal Data Records rsaetx:mal vor 1F1e9aste DOSE Grove: Telomes Alcshel McRoscoptc FwINGS ver xidnoy/2 | Spleen pms Jotmal Nor 120 McRosCOPTC PIDINGS SInifnlgalmemacteollryneccerlolsifsoct(mi(nmiimnailm)al) Tubular atrophy, cortical (minimal) HHaammoopsoitdeasrtisn,pipgrmiemnatril(yaoedreyratther)opotests (aintmal) Lymphocytalysts, increased (aintaal) NoOvaazbyn/o3r,malOviatziye/s2,foMurndenianl: GPlaanncdr/eais,,MKriednnaely/lG,iand/2, MMeasnednitbeurliacr LLyymmpphh NNooddss,/2.Mandibulaz Lymph Node/1, dsaaycsrifofictergeraowtpment:: 2t9erminal sacrifice ndeactzeopofsysstatrtatofutsre:atmpelnatn:ne0d8/t1e0r/m3i8nal Gdaactee ooff nenedcorfoptrseyat:aan0t6:/110/53/811/98 No findings noted ver Spleen SIinnfgllaemacteolrlyneccerlolsifsoct(mi(nsilmiaglh)t) HBaesmoospiodteersitns',pipgrmiemnatril(ysleirghytt)hropoiesis (aininal) NoKidanbenyo/r2m,alOivtaireys/1f,ouOnvdariyn:/2,PaAncdrreeansa,l KGliadnnde/yl/,l, AMdarnedniablulGalranLdy/m2p,h NTohdyem/i1s,, MMaensdeinbtuerliacr LLyymspphh NNooddee,/Z. 000383 `PATHOLOGY RERORE rage 78/146 TTeesstt ASrytsitcelme::TEexopmloaraALtCoOrHyOL2/6T-EdLaGyA GAaRYvLaNgTeE/Study/emiins/Rerasts PNrOoTpOaXthno.no.:+ 24929091303 Sponsor i 3M Toxicology Services Date. : 21.apr.19ss Individual Animal Data Records SJxotml ve: F1e21male DOSE GROUP: Telamer Alcohol MacRoscoprc FIGS rcroscopre FrwmiGs Atma vor 12 MACROSCOPIC FIIDINGS skin MrcRoscopre FrIGS skin Atma Wor 123 MACRoscopTC PTIDINGS . ndsaaayccstroifpoisfcyetrsgetaarttounpsent +: i pr2l9eacnonveedryrgercoouvpery ddaatcee ooff santdarotfoftretarceaastnmte:nt:050/181//1508/90 date of necropsy| + 20/11/38 No findings noted No tissues examined dSaaycsrifoifcetrgeartomwent necropsy status +: r29ecovery grou i planned recovery ddaattee ooff esntdarotfotfretartemaetnmte:nt:05/0181//1908/90 date of necropsy 20/11/98 Alopecia NoCsarbuneosrmaelxiatmiiensedvere found in any of the other Yo micro correlate asaycsrifoficetrgeraowtpment:: necropsy status: r29ecovery grow planned recovery ddaattee ooff esntdarotfoftretartemxetnmtesnt:050/81/11/03/898 date of necropsy |: 20/11/%8 000384 `PAmHOLOGT RERORT Page 73/146 TTeesstt ASrytsitcelme:: ETxipalonraAtCoHrOyL/2T0H-DOaGyR GNaRvLaAgTeY/Stud/yeniisn/eRrcasts PNrOoTpOaXtmho.no.:+ 24929003130 Sponsor + 3 Toxicology Services Date. : 21.apz.1099 Individual Animal Data Records ASDaeOtxS:mEalGROwUoP:: T1Fe2e3lmeamlaer Alcohol Mtacceanctsincuoepdr)c FmmiGs MrcRoscoprc PIGS ratmal wo: 125 acRoscopre FINDINGS MicRoscoPIC FrDIIGS Antmal Wor 126 MacRoscopC FrDIIGS acRoscop1c FrDIIGS No findings noted Wo tissues examined dSaaycsrifoifcecrgoroswman:i 2r9ecovery grow 2 nnecceroopfsystsatstaotfutsre:atmpelnatn:ned00/r1e0c/o3v8ery 2 dGaattee ooff nanedcroofpsytreatm+en0t4:/120/59/811/93 Yo findings noted No tissues examined dSaaycsrifoifcetregartomwent :: 2r9ecovery grow 2 Gnaetceeoposfystsatrtatofutsre:atmpelnatn:ned06r/1e0c/o3v8ery 2 Gdaattee ooff neencdroofpsytreats|:sn0c4:/129/53/811/93 No findtags noted No tissues examined 000385 PATHOLOGY REPORT rage 80/146 TTeesstt ASrytsitcelme:: ETxepolohraAtLoOrIyOL2/0E-LDOaRyR GACaRvYaLgAeTE!Stud/yemiisn/eRroasts PNrOoTpOaKthno.no.: 24929003130 Sponsor i 3M Toxicology Services Date + 20apei199s Individual Animal Data Records - Asetx:ma No: 1F2e7male DOSE GROUP: Telomer Alcohol cRoscopIc FrOIIGS aSaycsrifoifcetrgeartomewnt:: 2r9ecovery grow 2 nGeaccecoposfystsatarttuosf treaitmpelnatn:ned08/r1e0c/o3v0ery 2 ddaactee ooff enencdroofpstyreatm+en0t4:/120/53/811/98 No findings noted MrcRoscoprc FrDINGS No tissues examined FDsoaexst:tmarovro:: aT3e3tleomer Acrylat cRoscoprc PmIGS dsaaycsrifoficetrgeraomwepnc 2: t0eminal sacrifice ndaetceropofsysstattatofutsre:atmpelnatn:ed06/t1e0m/m9i8nal ddaattee ooff enencdroofpsytreatmen0t3:/110/29/811/98 Ho findings noted Microscope FrmmIGS | ver ISnifnlgalmemacetlolryneccerlolsifsoot(ai(nstlaiaglh)t) Pancreas Rpoptosts/single cell nectosts, exocrine (atnisal) Kidney/1 Tubular atrophy, cortical (atnimal) Kidney/2 Tubular atrophy, cortical (minimal) Spleen HHeozsoospiodkeersiins',ppigrmiesnatr.il(yineirnyatlh)iopoiesis (slight) 000386 PATHOLOGY REPORT Page 91/145 TTeesstt ASrytsitcelme:: TExEpLloMraAtOoWrOyL/2S8I-DOaGyR AGaRvYaAgTeE/Study/eRiins/eRraosts PNrOoTpOaXtnho.Ro.: 2502091303 Sponsor + 3M Toxicology Services Date i 21.apz.1999 Individual Animal Data Records SErDaOXtS:eEalGRNOoUrP: vT3ea3lloemer Acsylat M(ccronotsicnouperd)e PrwmIGs Aatmal wor 34 croscopte FrwmiGs MrcRoscopre FIDDNGS Liver Kidney/2 Spleen an1dtiuler Lyegh Node/ Ma2ndibolar Iysph Node/ uLmybmeprh oNofdSee/c1ti(o0n)s less than protocol for Mandibular N`HoAodsarebennntoaorlsmiaGcllaintLdiy/erlsp,hfAoodudznsed,nainMl:anGdlTaienbsdtu/elzsa,/rl,TLhyynTmgeishst,eHso/d2e,/2. dSaayesifoifcetrgeraomepnt :: 2b0eminal sacrifice nGaetceroopfsystsatrtaotfutsre:atpmelnatn:ned06t/e1r0m/i3n8al ddaattee ooff neencdroopfsytr|eatmen0t3:/110/29/811/98 No findings noted SIinnfgllaemacteolrlyneccezlolstfsoot(at(natiznatlz)al) Interstitial influmation, lymphocytic (minteal) Hazopoasts, prisasily erythropotesis (sintmal) Plasmacytosis (slight) Plasmacytosis (slight) NoTesatbenso/rlm,aliTtesiteess/f2o,unAdrtenn:alPanGclraenads/,i,KAiddnreeyn/a2l, Gland/ 2, Thymus, Mesenteric Lymph Node. 000387 PATHOLOGY REPORT Page 82/146 TTeesstt ASrytsitcelme:: TEexipcluoRraAtLCoOrHyOL2/6TE-IDOaGyR AGaRvAagTeEStud/yeniisn/pRicasts PNrOoTpOaXthmo.no.: 24325903130 Sponsor + 3M Toxicology Services Date. + 21.apz.1995 Individual Animal Data Records AsDaeOtxS:mEalGRNOoUrP: aT3e5lleomer Aceylat ocRoscoRIC FINDINGS acroscopre FTIDINGS siver Spleen antmal Nor 36 MACROSCOPIC FINDINGS MrcRoscoPIC FnINGS Liver Kidnoy/1 spleen dSaaycsrifoifcetrgesrcampent :: 2t8eminal sacrifice nGdeaacttreeopoosffysetsnatdrattoufsoftretartemaietnaptel:natn:n0e20/d161/t/1e90m8/i5n8al Gate of necropsy + 03/11/38 Yo findings noted Inflamatory cell foct (intsal) Hesopotests, primarily erythropoiesis (sintmal) NoKidanbenyo/r2m,aliTtositeess/f1o,unTdesitn:es/P2a,ncrAedarse,nalKiGdlneayn/dl/,i, AMdarnedniablulaGrlaLndy/m2p,h TNhoydmei/s1,, MYeasnednitbeurliacz LLyysspphh NNooddee,/2. dSaaycsrifoifcetrgeraotwment:: t28eminal sacrifice nGeactreoposfysstatrtatofuxse:ataplnatn:ne0d6/t1e0r/m5i0nal Gdaatcee ooff ennedcroofpstyrasm+sn0t3:/110/23/811/98 No findings noted ISinnfgllaemmacteolrlyneccerllosifsool(mi(nsi1miaglh)t) TInutbeurlsatritaitarlophiyn,flcaomrattiicoanl, (lmyimnpimhaolc)ytic (iniml) Hemopotests, primarily erythropoiesis (minimal) 000388 `PATHOLOGY RERORT rage 83/146 TTeesstt ASrytsitcelme::THELxGpHlEoRrAaLtCoOrHyOL/2T8E-LDOWaEyR GACaRvYaIgAeTE/Study/PiSn/prRoasts PNrOoTpOaXthno.no.: 24523803130 Sponsor: 3M Toxicology Services Date. : 21.apr.1959 Individual Animal Data Records sDAOnzStEalGRwOUoP:: 3HT6aelleomer Acrylat M(rccoanotsicnuoerdi)c FnDINGS MTuymmbae NoofdeS/a1cti(o0n).s less than protocol for Mandibular 4 MToesatbenso/rlm,alTiatsiteess/f2o,unAddrien:nalPaGnlcarneda/si,, KiAddnreeyn/a2l, Gland/ 2, Thyms, Mesenteric Lymch Node, Manctilar Lymph Nodes. Atma Nor 37 . MacRoscortc FIGS dsaaycsrifoifcetrgearmeontw: t29eminal sacrifice ndeacteroposfystsatrtatofutsre:atmpelnatn:ned06t/e1r0m/i9n8al ddaactee ooff ennedcroofpstyreatm+en0t4:/110/33/811/58 Yo findings noted MrcRoscoste FmDNGS Liver sIinnfgllaemmcaetlolryneccerllosifsoci(si(nstezdaelz)ate) Kidnoy/1 Tubular atrophy, cortical (sinizal) To Spleen HEeemmoospiodteersitns',pipgrmiemnatril(yatenrzyatlh)ropoiesis (slight) Ma7ndibular Lymph Node/ Plassacytosis (slight) NToesatbenso/r1m,alTietsiteess/f2o,unAddcine:nalPanGclraenads/,i, KiAddnreeyn/a2l, Gland/ N2,odeT/hZy.mul, Mesenteric Lysgh Node, Mandibular Lyreh 000389 `PATHOLOGY REPORT TTeesstt ASrytsitcelme:: TEExpOlMoAraAtLoCrCHyOL2/6T-EDLaOyR GMaRYvLaAgTeE/Study[eFinS/eRraosts Sponsor 1 3M Toxicology Services rage 84/148 PNrOoTpOaXthno.mo.: 24523003130 Date : 21.apr.1999 Individual Animal Data Records asnmi:mal vor a30le DOSE GROUP: Telamer Acrylat MacRoscopc FrDmGS dSaaycsriofficetregarcomuepnt :: t29amdnal sacrifice dnaetceroopfsyscsatrattusof trexitapslnatn:ne0d6/t1e0r/m5i6nal Gdaattee ooff nenedcroofpstyreatm|:en0t4:/110/39/811/30 No findings noted Macaoscopte FrmmGs Liver Spleen SIinnfgllaemmcaetlolryneccerlolsifsoci(si(nsilziaglh)t) HHeemmoospiodteersiins',pipgrmiemnatril(yaienxizyatlh)ropodesis (slight) Ma1ndibular Tysph Node/ Plasmacytosis (slight) Ma2ndibular Lyeph Node/ Plassacytosts (slight) MAKodirdaenbennyao/lr2m,GallaTinetdsi/te2as,s/f1To,hunyTdmessi,tne:sM/eP2as,necnrAteersresin,calLKiyGdalnpeahyn/dNl/o,id,e. Animal vor 33 McRoscopIC PROCS : dSaaycsriofficetrgeratomuenpt:: 2t9aminal saccifice dnaetceroposfyssttaattusof treaitmpelnatn:ned06t/e10r/m9i8nal ddaattee ooff maencdzoofpsytreat+ a0n4c/110/33/811/30 o findings noted 000390 PATHOLOGY REPORT Page 85/146 TTeesstt ASrytsitcelme:: TExepilonraAtCoOrHyOL2/8-SDLaOyR GAaRvYaLgTeE/Study/eimn/erRcasts PNrOoTpOaKthno.ho.: 24923503130 Sponsor: 3M Toxicology Services Date. 21.pr.1999 Individual Animal Data Records - Asaext:mal wor a39le DOSE GROUP: Telcmer Accylat Macaoscorze FnmmGs iver Pancreas Kidney/1 spleen rtm vor 40 MACROSCOPIC FIIDIIGS MrcRoscoprc PIGS Liver Kidney/1 Spleen mms Ma7ndibular Lysph Node/ . SIinnfgllaemmcaetiolryneccazlolsifsoci(mi(nsilmiaglht)) AEpxoopctroisntes/astizonpghlye,ceflolcalnec(tmoisniism,al)exocrine (ainimal) TPuebluvliacrinaftlraopmhmya,tiocno,rtliycmaplho(imdini(maailn)isal) HHaemmoopsoitdaasrtisn,ppirgimseanstil(yatenrizyatlh)iopoiesis (slight) NMToeessatebannsto/re2mr,ailcAidtLciyeemnspahdfNooGudlnead,ndt/Mn1:a,nKdAiidbrnueelnyaa/r2l,LyGlmTapenshdt/eN2so,/dle,/F1h,yms, Mandibular Lysph Node/2. Sdaaycsrifoficetrgeraotwment:: t29aminal sacrifice ndeacceroposfystsatrtaotfutsre:atmpelnatn:ned06t/e1r0m/i5n8al adattae ooff nenedcroofpstyreatm+en0t4:/110/39/811/30 No findings noted Inflammatory cell foct (slight) Tubular atrophy, cortical (ainimal) HHeemnoospoitdeesriisa,pipgrmiemnatril(yaienrdayatlh)ropoiesis (nintaal) Lymphocytolysis, increased (sLight) Congestion/esythrophagocytosis (sederate) 000391 PATHOLOGY REPORT Page 86/148 TTeesstt ASrytsitcelme:: ETexLpOlHEoRraAtLoCrOyOL/2T0E-LDOaGyR GAaCRvIaAgTeE/Study/PRiInS/eRroasts PNrOoTpOaXthno.no.:+ 20s2s003130 Sponsor i 3M Toxicology Services Date. 21.apr.1sss Individual Animal Data Records rDSaOxtS:mEalGRONeU:P: aT40ellecmer Aceylat M(ccronotsicnoupezd)e pric retmal wor 41 acRoscoprc FrwmiGs Mrcroscopze FrmiGs rtm vor 42 cRoscoprc FrwmiGs MxcRoscopte FrwmIGS . N2To,esatYbeensso/er1nm,taelirTtiesicteesLsy/fm2op,uhnANdordieenn,:alMPaannGcdlraienbsdus/l,ia,kKiALddynrmeepynh/a2lN,odGel/a2n.a/ sdaaycsrifoifcetrgermoeunps:: neceopsy status: r29ecovery grow planed recovery ddaattee ooff estnadrtofoftretartemaetnmte:nt:03/0161//1908/90 date of necropsy + 16/11/98 No findings noted No tissues examined dsaaycsrifoifctergeraotwment:: necropsy status: z29ecovery group planned recovery ddaattee oOff esntdarotfotfretartemaetnmte:nt:03/0161//1903/98 date of necropsy |: 18/11/38 Yo findings noted No tissues examined 000392 sATHOLOGY REPORT rage 87/146 TTeeastt ASrytsitcelme:: TEoxipaleonraAtLorCyO2H8O-DLaSy GNaRvAaTgEe/Study/eiRVnS/Rerasts PNrOoTpOaXthno.no.: 24525001303 Sponsor: 3M Toxicology Services Date. t 21.apr.1999 Individual Animal Data Records JSDaOEtS:mEalGRoeure: w4Ta3elleemer Acrylat MacRoscoPIC FmINGS MrcRoscopre FDINGS ratmal Nor 45 cRoscopre FDIIGS rcRoscopre FIGS CO amtsver a6 MACROSCOPIC PIDIIGS. dnSaaeyccsrriofpoisfcyetrsgetatarmetnout s:: pr2l9eacnonveedryrgercoouvpery daatcee ooff satnadrtofoftretsrtemaecnatm:nc:03/0161//1300/38 ace of necropsy + 18/11/38 No findings noted Yo tissues examined nasaayccsrroipfofaiycetsrgetartamotenuutps::5 rp29leacnonveedryrgecroovwer2y 2 GGaattea ooff ssntdarotfotfretartemaetnmte:nt:03/0161//1903/58 date of necropsy| 02/12/98 Mo findtngs noted No tissues examined dSaaycsrifofictergeraotwment:+ 2r9ecovery grow 2 ndaecceropofsystsatrtaotfutsre:atpmelnatn:ned06r/1e0c/o5v8ery 2 ddaatcee ooff amnedcoopfsytreatm|:en0t2:/120/39/811/38 No findings noted 000393 PATHOLOGY REPORT rage 88/146 TTeesstt ASrytsitcelme:: TExepilonraAtCoOrHyOL/2T0E-LDOaEyR AGCaRvLaAgTeE/Study/oRiinS/R?oasts PNrOoTpOaXthno.mo.: 24325003130 Sponsor: 3M Toxicology Services Date : 21.apr.1s99 -- eee ---- a---- -------- Individual Animal Data Records srDeOxtS:EmGROvUoPr: aT46elleemer Aczylat MacRoscopTe FIXOMGS Ho tiasues examined Atma Nor 47 1acroscopre Fmics ~ sdaaycsrioffictergersotumpen Reccopsy status i: i rp29leacnonveedrysegcroovwery2 2 ddaattee Gate ooff of nseetncadrrtoopfostfyretartema+etnm0te2:n/t1:20/35/08161//1508/58 No findings noted Mxcroscopre FrOIIGS No tissues examined saeaxt:aal wo: r1e2n9ale MacRoscopre promiGs dSaaycsrifoficetrgeartomwent +: t20eminal sacrifice dnaetceroposfystsatrattusof tresitaostnhte:r 08/10/58 ddaattee ooff ennedcroofpsytreatm+sn0t5:/110/49/811/98 No findings noted McRoscopTc FrDINGS iver SIinnfgllaemmcaetlolryneccerlolsifsocl(ai(nsilziaglh)t) Spleen HHeenmoopsoiideesrtisn,pipgrmieznatril(ysienirzyatlh)ropoasts (slight) 000394 `PATHOLOGY RezORT rage 85/145 TTeosstt ASrytsitcelme:: TEoxipalmonraAtLoCOrHyOL2/0F-TDLOaGyR GAaCRvYaLgAeTEStud/yemiisn/eRroasts PNrOoTpOaXthno.no.: 24929903130 Sponsor i 3M Toxicology Services Date. i 21.pr.1988 Individual Animal Data Records ADmOtxS:mE aGROYUoPr: =T1e29lnomer Acrylat M(rccornotsicnuoepdr)c FmmNGs Aatmal wo: 130 acroscoprc FronGs MrcRoscopte FmINGS Liver Kidnoy/2 Kidnoy/2 Spleen hy NAKodirdanebennyao/lr2m,aGlloainvtdai/re2ys,/lf,TohuyOnmvdiasci,yn/:2M,ePasAnedcnrrteeeanrsai,lc GKliadnndesyl/,1, Lyegh Node, Mandibular Tyeph Node/1, Mandibular Lymph Node/2. dSaaycsrifoifcetrgeraotwment:: 2t8ersinal sacrifice dnaetcezoposfystsatrtatofutsre:atmpelnatn:ned08t/1a0m/m9i8nal ddaattee ooff neencdroofpsytreatm|:en0t5:/110/43/811/38 Yo findings noted SInifnlgalmemacetlolryneccerlolsifsoel(ai(nsilmiaglh)t) Hepatocellular vacuslation (aintaal) Tubular atzophy, cortical (minimal) Tubilar atrophy, cortical (minimal) HHoemmoopioitdeesrtisn,pipgrmiemnatril(ys1eiGrhytt)hropotesis (minimal) Sysphold atrophy - favolution (minimal) No2, aAbdnzoernmaallitGiLeasnd/f1o,unAddzine:nalPanGclraenads/,2,ovMaezsye/nlt,eroivcary/ TLyymmpphh Nooddee/,2.Mandibilar Lysph Node/1, Mandibulaz 000395 PATHOLOGY REPORT Page 50/146 TTeesstt ASrytsitcelme:: ETxrpilooraAtCoOrHyOL2/0F-EDLaHyR GMaRYvIaAgTeE/Stud/yeriisn/eRroasts PNrOoTpOaKthno.no.: 24929903130 Sponsor + 3K Toxicology Services Date. i 21.apr.asss Individual Animal Date Records nBsoetsx:ah aGovveer: T1re3e1lseamleer Acrylat MacRoscopIC FIDINGS dRSaaayccsrroipofsifycetsrgetraatotmueunpst::: tp2l0eamninneadltsearcmriinaflice ddaattee ooff setnadrotfoftrteraetamtemnetn:t:04/0181//109/058 Gace of necropsy| 05/11/98 Yo findings noted acroscopte FrmmIGs Liver SIinnfgllaemmactelolryneccorllosifsoct(si(naitsnatla)al) Spleen HHeessoopsoitdeesrtisn,pipgrmiemnatril(ysleigrhytt)hropoiests (ainimal) NAoKdirdaenbennyao/lr2m,aGllaiOnvtdai/ze2ys,/lf,TohuyOnmvduaszi,yn/:2Y,ePsaAendnczrteeeanrsai,ic GKLliyadsnnpdeh/yl/N,lo,de, Mandibular Lymph Node/1, Mandibular Lymph Node/2. etmal vor 132 MACROSCOPIC FTIDINGS dSaaycsrifoifcetrgeraotwapms : 2t0eminal sacrifice : ndeacteroposfystsatrtaotfutsre:atmpelnatn:ne0d8/t1e0m/i5n8al dGaattee ooff ennedcroofpstyreatm+en0t5:/110/43/811/90 No findings noted 000396 `PATHOLOGY REPORT Page 91/146 TTeesstt ASrytsitcelme:: TErxpiloonraAtLoCrCHyOL2/0A-TDLaGyR GNaRYvLaNgTeE/Stud/yeRiisn/eRrcasts PNrOoTpOaXthmo.no.: 29452091303 Sponsor + 3M Toxicology Services Date. + 21.pr.1sss Individual Animal Data Records rsaetx:mal ve: 1F3e2male DOSE GROUP: Telomer Aceylat MacRoscoPTC FINDINGS Liver Pancreas Spleen Jotmal wo: 133 MacRoscoRze FDIS xcroscope PromGS iver Spleen ym - . Inflamatory cell foct (mintaal) Exocrine atrophy, focal (intsal) HHaammoopsoitdeesrtisn,pipgrmiemnatril(ymienirzyatlh)ropoesis (ainimal) No`Ovsahznyo/ir,aaloviatciye/s2,foAudnrdenian:l GKliadnnde/yl/,1,AdKridenneayl/zG,iand/2, NTohdyem/i1s,, NMeasnednitbeurliac: Llyyempphh NNoeddee,/2.Mandibular Lymph dSaaycsrifoifcetrgeartmoenutp:i 2t9erminal sacrifice dnaetceroopfsystsatrtaotfutsre:atmpelnatn:ne0d8/t1e0r/m9i8nal ddaattee ooff neencdroopfsytreatmen0t6:/110/59/811/98 No findings noted SIinnfgllaemmactelolryneccerlolsifsoct(sl(isglhitg)ht) HHeenmoopsoitdeesrtisn,'pipgrniemnatril(ysleirghytt)hropoiesis (slight) Lymphotd atzophy - involution (aintmal) NKoidanbenyo/r2m,aliOtviareys/1f,ouOnvdaziyn/:2,PaAncrreenaasl, GKliadsnde/y1/,1, AZdyrsepnhalNodGeL/a1n,d/2M,anHdeisbsunltaerriLcymLpyhaNgohdeN/od2e., Mandibular 000397 PATHOLOGY REPORT Page 52/146 TTeesstt ASrytsitcelme:: TExEpLloArAaLtCoOrHyOL2/T0E-LDOaRyR GAaCRvNaAgTeE/Study/eFiins/eRraosts PNrOoTpOaKthno.no.:i 24523803130 Sponsor + 3M Toxicology Services Date t+ 21.apr.1999 Zndividual Animal Data Records rsatx:m vor 1F3e4asle DOSE GROUP: Telomer Acrylat MAcRoscoprc FNDDIGS MacRoscopIc FINDINGS iver Kidney/2 spleen Thyme animal Ne: 138 : dSaaycsrifoifcetrgesrcmoanuep:: t29eminal sacrifice Gnaatcaeoposfystsatrtaotfutsre:atmpelnatn:ned00t/e1m0m/i3n0al Gdaattee ooff ennedcroofpstyr|eatmen0t/:110/53/811/98 No findings noted Inflammatory cell foci (atntsal) I`Tnutbeurlsatritaitarlophiyn,flcaomrattiicoanl, (lnyimnipmhaolc)ytic (minisal) HHeemzoopsoitdeesrtisn,ppirgimmeanrtil(ysleigrhytt)hropoiesis (sintal) Lymphocytalysis, increased (mintaal) NOovaazbyn/oLr,aalodvtaciye/s2,foAurndenianl: PGlaanncdr/ela,s,MrKiednnaely/lG,iand/2, MMeasnednitbeurliacr TIyyeepehh NNooddee,/2.Mandibular Lymph Node/1, dSaaycsriofficatrgeratomuenpt:: 2t9erminal sacrifice ndaetcer'oopfsystsatrtaotfutsre:atpmelnatn:ne0d8/t1e0m/m9i8nal cdaattee ooff neencdroopfsytr|eatmen0t6:/110/59/811/98 Yo findings noted 000398 `PATHOLOGY REPORT Page 33/146 TTeesstt ASrytsitcelme:: TExepulonrAatCorHyA2T0-Day NGAaIvAaTgeS/Study/eriins/Ferasts PKrOoTpOaKthmo.ho.: 24523003130 Sponsor + 3M Toxicology Services Date 2Lapr.19ss Individual Animal Data Records NDEOaxSt:EalGroYvore: 1PT3ee8alrolmeer Acsylat Macaoscortc FIIDNIGS iver spleen Ma1ndibular Iysph Node/ Atma wer 136 caoscortc FmmGS Microscopic FINDINGS iver Kidney/2 Mzenal Gland/1 Spleen ym Ma1ndthlar Lymph Nedo/ Inflamatory call foot (minima) HHeenmoopsoitdeesrtisn,pipgrmiemnatril(ys3edgrhytt)hropoiesis (ninizal) LPylmapshmoatcdythoysptserp(lsaisgihat)(slight) NAoKdirdanebennyoa/rl2m,aGlliaOntndiz/ey2s/,lf,TouhnOyvdmasri,yn/:2W,ePasAnecdarzteeeanrsai,lc GKLilydaannpedhy//1N1,le,ds, Mandibular Lymph Yode/2. csaaycsrifofictergeraotwment:: 2t9eminal sacrifice ndeactreoposfyststaarttusof treaitmpelnatn:ned00/t1e0r/m9i8nal ddaattee ooff ennedcroofpstyreatm+en0t6:/110/59/811/98 No findings noted sIinnfgllaemmcaetlolrynceeclrlosifsoe(at(nstiagahlt)) Interstitial inflamation, lymphocytic (mintmal) Extzacapsulas nodule present HHeesmoospiodteersiins',pipgrmiemnatr.il(yaoedreyratther)opoiesis (aintmal) Lymphotd atzophy - involution (minimal) Plasmacyvosis (slight) 000399 `PATHOLOGY REPORT Page 94/146 TTeesstt ASrytsitcelme:: TEExpLlEoRraAtLoCrOyHOL2T0T-LDOaGyR GAaRYvLaXgTeE/Stud/yPRiiSn/ERIoast|s NPOrToOpKathmo.no.: 24525003130 Sponsor 1 3M Toxicology Services pate t 21.apr.1998 Individual Animal Data Records AsonszttalGrowuopr: T1F3ee6mraelmeer Acrylat + M(rccornotsicmouperdc FrwIIGS Ma2ndibular Lymph Node/ antmal wor 137 Macaoscorrc FmIIGS MrcRoscopze PomIGS rntmal ver 130 McRoscopIc FromIGs MrcRoscopc FING Lymphoid hyperplasia (slight) NoOvaazbyn/oLr,aalOviatziye/s2,foMunedatns: GPlaanncdr/e2a,s,MeKisdennetye/rli,c Lymph Node: dSaaycsrifoifceregsreanpt:: 2r9ecovery group RGaactreoposfysstatrtatofutsre:atmpelnatn:ned08r/e10c/o5v8ery dGaattee ooff enencdroofpsytr|eatmen2t0:/10/59/811/98 Yo findings noted Yo tissues examined dSaaycsriofficetrgeraomewnt i: necropsy status: pr29elcaonveedryrgercoouvpery GGaattee ooff setnadrotfoftrteartemaetnmte:nt:050/61/11/03/098 date of neczopay 20/11/90 Yo finatngs noted No tissues examined 000400 `PATHOLOGY RavoRT rage 95/146 TTeesstt ASrytsitcelme:: iEuxpaleonraMtCoOrHOyL/2T8E-LDOaEyR GAaRvaYgAe,Stud/yORiiSn/eRroasts PNrOoTpOaKtnho.ho.: 25452091303 Sponsor 1 3M Toxicology Services Date. 21.apr.1099 Individual Animal Dats Records Asetx:ma vo: F13e9male DOSE Group: Telemer Acrylat MACROSCOPIC PIDIHGS Macroscopre nmniGs Atma vor 141 MACROSCOPIC FINDDIGS MacRoscopre FnTNGs Animal vor 102 MacRoscopze FImINGS ndsaaayccseroipfosfiyctersetgaartcumosenut p:i: r29ecovery group planned recovery ddaattee ooff estnadrtofoftrteraetamtemnetn:t:05/0101//1900/30 date of necropsy + 20/11/38 No findings noted No tissues examined nsdeaacycrsroipfosifycetsrgtearatutosmuenpt::i pr2l9eacnonveerdyrgecroovwery2 2 ddaattee ooff esntdarotfoftretartemaetnmtesnt:05/0181//1508/98 Gate of necropsy |: 04/12/38 No findings noted No tissues examined doarysioefntrveiatnmJeR nt: i29 onJiro dnaetceroposfystsatrattuosf treaitmpelnatn:ned08r/e10c/o3v0ery 2 ddaattee ooff neencdroopfsyt.reatm+en0t4:/120/59/811/90 No findings noted 000401 PATHOLOGY REPORT nage 36/146 TTeesstt ASrytsitcelme:: TExEplLoraAtLCoOrWyOL2/6TE-LDOaGyN GAaCRvIaAgTeE/Stud/yeniisn/eRrcaets PNrOoTpOaKthno.ho.:i 24929003130 Sponsor: 3M Toxicology Services Date. 202pr.1999 Individual Animal Data Records - seAnxt:al wor F1e0m2ale . DOSE GRovP: Telomer Aceylat MrcRoscorre FmmmGS No tissues examined sotmal wo: 143 WcRoscopte FwmIGs i nSaeayccsrroifpoisfcyetsrgetraatotmueunpst::: 2r9ecovery group 2 planned recovery 2 ddaattee date ooff of nseetncadrrotopfsoyftretartema|:etnm0te4:n/t1:20/59/08181//1908/58 acroscoprc rwmics Yo findings noted No tissues examined Amaxt:mal wo: H4a9le Dose Group: McRoscorTe FImINGS Mrcaoscoprc rics saaycsrifoifcetrgeartampent necropsy status +2t0erminal sacrifice i planned terminal ddaattee date oOff of eStnadrtofoftretartemastnmtesnt:62/0161//1308/90 necropsy |: 03/11/98 Yo findings noted Liver Xudnoy/1 Spleen sIinnfgllaemmcaetlolryneccerlolsifsoct(si(nsilziaglh)t) Tubular atrophy, cortical (atntsal) Hamopolasis, prisarily erythropoiesis (minimal) 000402 PATHOLOGY REPORT Page 98/146 TTeesstt ASrytsitcelme:: TExepilonraMtCoOrWyL/2I0E-DIaOyR GACaRvYaLgATeE,Stud/yRRiMnE/IRCaSts PNrOoTpOaKthRo.ho.:t 24529903130 Sponsor +3M Toxicology Services Date : 21pr195 Individual Animal Data Records Asnxt:al wor 5a1le Dose Grove: (ccaonotsicnoupezd)e FIGS MrcRoscopzc FIDINGS Liver spleen retmal wor 52 MACROSCOPIC FINDINGS Mrcaoscoprc FnwmiGs Liver Spleen Mesenteric Lymph Node Ma1ndibular Lymph Node/ Ma2ndlbular Tyeph Node/ : Yo findings noted Inflammatory cell fool (minimal) HHeemmoopsoitdeesrtisn, ppirginmeanrtil(ystenirzyatlh)ropotesis (slight) NKoidanbanyo/r2m,aliTtesiteess/f1o,usTdesitne:s/P2a,ncArdesrse,nalKidGnleayn/dl/,i, AMdarnedniablulGalranTdy/e2p,h TNohdyem/s1,, MMaensdeinbtuelrairc LLyymmpphh NNooddee,/2. dSaaycsrifoficetrgeraotwment:: 2t8eminal sacrifice ndaetceroposfystsatreaotfutsre:atmpelnatn:ned06/t1a0m/m9i8nal ddaattee ooff enencdroofpsytr|eatmen0t3:/110/23/811/38 Yo findings noted Inflammatory coll foot (atntaal) HHeenzoopsoitdeesrtisn,pipgrmiemnatril(yaienirzyatlh)ropoiesis (minimal) Congestion/erychrophagocytosts (minimal) LyPlmapshmoaicdythoyspiesrp(lsalsigihat)(sight) Congestion/exythrophagocytosis (slight) Congestion/ezythrophagecytosts (slight) 000403 `PATHOLOGY REPORT Page 39/148 TTeesstt ASrytsitcelme:: TExepilonraAtLoCrOHyOL2/6T-EDLaEyR GAaRYvLaAgTeE/Study/eRiWnS/aRRacsts Sponsor: 3M Toxicology Services PNrOoTpOaKtmho.no. Date : 24529003130 21.pr.1999 ---- re-------------------------------------- Individual Animal Data Records rseoxts wo: 5=2 Dost rove: MrcRoscopIC FDIS (contimued) atm Nor 53 MACROSCOPIC FRDIIGS `McRoscoprc FnwINGS Liver Kidney/1 Spleen % Atma No 54 croscopte PromIGs NoKidanbonyo/m2m,alTdetsiteess/f1o,unTdesitn:as/P2a;ncAredacse,naXlidGnleayn/d/1d,, Arenal Gland/2, Thymis. dsDaeayccsrroipfofsiyccersgetraaomeptnut s:2: p9tleamninneadltesramcirniaflice Gaxttee ooff setnadrtofoftrteraetamtemnetn:t:030/61/11/09/898 Gate of neczopsy + 04/11/98 Yo findtags noted Inflammatory cell fock (slight) TIunbcuelrasreicatiraolphiyn,nlcaomrattiicoanl, (lmyimnpimhaolc)ytic (mininal) HHeemmoospiodleersitns',pipgrsiemnatril(yaienriyzatlh)ropotesis (slight) No`2,Taaa"btTnahosyr/m1mu,as,liTMteesitseesesn/ft2oe,urniAdcdrLieny:nmaplPhaGNnolcdraeen,ads/,iM,anKAiddirnbeeunyla/a2lr, GLlyamnpdh/ Node/3, Mandibular Tyeoh Hode/2. dSaaycsrifofictergeraotmwepnt :: 2t9ersinal sacrifice PGaatceeoposfyscsatrtatofutsre:atmpelnatn:ne0d6/t1a0m/m9i0nal GGaattee ooff ennedcorfoptrseyat:men0t4:/110/33/811/38 000404 `PATHOLOGY REPORT Page 100/146 TTeesstt ASrytsitcelme:: TExepilonraAtCoorHOyL/2S0E-LDOaGyR GAaCRvYaLgATEStud/yPai/nmRoasts Sponsor i 3M Toxicology Services PNrOoTpOaXthno.no.: Date 24523003130 21.apr.2859 Individual Animal Data Records Asnxt:al No a54le Dose Grove: M(ccRonOtSiCnOuPedI)C FINDINGS MrcRoscoPrC FINDINGS ver Kidney/1 Spleen nisl Nor 55 MACROSCOPIC FIDDNGS acRoscorre FXDNGS iver Pancreas Spleen Ma1ndibular Tysh Node/ No findings noted ISinnfgllaemmacteoilryneccatlolsifsoct(mi(nsilmiaglh)t) Eyaline cast(s) (atntsal) HHeezmoospiodtaersitns',pipgrmiemnatril(yineirzyatlh)ropoiesis (ainimal) NoTasatbenso/r1m,aliTtesiteess/f2o,unAddcine:nalPaGnlcraenads/,i, KAiddnreeyn/aZl, Gland/ 2N,odTahly,musM,anMdeisbeunltaerriLcymLpyhaHpohdeN/od2e., Mandibular Lymph dSaaycsriofficetrgeraotwment:| 2t9erminal sacrifice ndaetceroopfsystsatrtaotfutsre:atmpelnatn:ne0d6/t1e0r/m9i8nal ddaattee ooff neencdroopfsytr|eatmen0t4:/110/39/811/98 Yo findings noted Inflammatory cell foet (slight) Rocptosts/single cell neczosis, exocrine (slight) HHeemmoospiodteersitns',pipgrmiemnatril(yaienrizyatlh)ropoiesis (sLight) Plasmcyvosis (slight) 000405 `sAmHOLoGY REPORT rage 101/146 TTeesstt ASrytsitcelme:: TEexipolmonraAtCoOrHyL/2T0E-IDOaGyR AGNaIvLaAgTeE/Study/PRiinS/pRRoasts PNrOoTpOaKthno.ho.:+ 24525003130 Sponsor + 3M Toxicology Services Date. t 21.apr.1999 Zndividusl Animal Data Records aSetxm:al Nor a85le Dos cove: M(ccRonotsicmoipeId)c PIIDINGS MaTndtoular Lymph Node/ Aatmal No: 56 Plasmicytosts (slight) HToasatbenso/rlm,aliTcaisetess/f2o,unAddcine:naKliGdlneayn/dl/,1, KAiddrueoyn/a2l, Gland/ 2, Thymis, Mesenteric Lymph Node. McRoscopIC FINDINGS. Ltver Kidney/1 Kidney/2 Arenal Glana/1 Spleen ym dSaaycsrifofictergeramaepnt :: 2t9erminal sacrifice ndaetceropoafystsatrattusof treatpmelnatn:ne0d6/t1e0r/m9i8nal ddaattee ooff enencdzoopfsytreatm+en0t4:/110/39/811/98 Wo findings noted Inflamatory cell foct (xintaal) Tubular atrophy, cortical (minimal) HTyuabliilnaez acatsreo(psh)y, (caoirntiniacla)l (minimal) Extracapsular nodule present HHeemsoopsoitdeesrtisn,'ppirgiaemnatril(yatenrizyatlh)ropotesis (atntsal) LLyymmpphhooctydtoaltyraoipsh,y -inicnrveoalsuetdio(nsli(gahitn)tnal) NTMoeasnatabelnsbo/ur2lm,ailcMidLtzyiemenspahlfoNouGdlnead/n1di,/n2:,MaPnMadenicsrbeeunaltsae,rriTLceyLsstygeshsp/Nhlo,dNeod/eZ,. 000406 `PATHOLOGY RERGRT rage 102/148 TTeesstt ASrytsitcelme:: ETexipolaonraAtCoCrHyOL2/8F-EDLaOyR GAaCRvYaLgAeTEStud/yeNiSn/erRoasts PNrOoTpOaKthno.ne.: 29452081303 Sponsor + 3M Toxicology Services Date. + 21.ape.1999 Individual Animal Data Records nSEtGm:al vo: a87le Dos Grove: McRoscoPIC FIGS acaoscopte PnmNGS antaal Hor So MacRoscoPrC FIIDINGS sacroscoprc FrmmNGs | antmal No: 59 MACROSCOPIC FINDINGS saaycsrifoifcetrgerampens:: r29ecovery group ddnaaectceerooopffsyastnsadtrotafotfturetssrt:eaascnpetln:atn:n0e3/0d161r//1e30c8/o3v8ery "ace of necropsy + 16/11/38 No findings noted No tissues examined dSaaycsrifofictergesrcmoenutp:1 r29ecovery group ddnaaettcaarooopffsyestnsadtrtoafotfturetsarte:maetnmptel:natn:n0e30/d61/1r1/e03c/8o5v8ery date of necropsy| 16/11/38 No findings noted No tissues exantned sdaaycsrifoifcetrgeratomuenpt:: necropsy status: r29ecovery group planned racovary ddaattee oofz estnadrtofoftretartemaetnmte:nt:03/0161//1908/50 date of necropsy + 18/11/98 Yo findings noted 000407 `PATHOLOGY RERORT Page 103/146 TTeesstt ASrytsitcelme:: TEexupalaonraAtCoOrHyOL2/8F-EDLaEyR GAaRvaAgTeEStud/yeRiisn/aRroasts PNrOoTpOaXthno.no.: 25452001303 Sponsor + 3M Toxicology Services Dace. 21.apr.1939 Individual Animal Data Records sAenxi:mal vor N5a9e Dose Grove: MacRoscopze FDIS ratmal ver 61 McRoscoRte FINDINGS Eyes MICROSCOPIC FINDINGS yes Atma vor 62 MACROSCOPIC PRDIIGS 3 rcRoscopte nics . No tissues examined Rsdaaayccsrroipfoeifycetsrgetraoawtptmeunst::: r2e9covery group 2 planed recovery 2 ddaatcee ooff astnadrotfotfretartemaetnmte:nt:03/0161//1508/98 dace of necropsy + 02/12/9% Lens: right side Reduced in size NTosasbuneosrmaslxiatniiensedwere found in any of the other Pa(rmtoodsebraittea)l i(ncofrlzaemlaattiesontdouGsROtSoSbflionoddinsge)mpling dSaaycsriofficetrgeartmoenutp:: e29covery grow 2 dnaetceroopfsystsatrtaotfutsre:atmpelnatn:ne0d6/r1e0c/o5v8ery 2 ddaatcee ooff naencdroopfsytreatm+en0t2:/120/39/811/98 No findings noted No tissues examined 000408 PATHOLOGY REPORT Page 104/146 TTeeastt ASrytsitcelme::TEHxpElRorAaLtCoCrHyOL2/S0E-LDOaGyR GAaCKvIaAgTeE/Study/PPiInS/PRTaosts PNrOoTpOaXthmo.no.: 24923091303 Sponsor + 3M Toxicology Services Date. + 2Lape.sss Individual Animal Data Records aSnect:aad wer s8a2le Dost Group: McRoscorre FIDINGS MrcRoscoprc FnmINGS asunx:te wer F1eSmale MacRoscoPrC FIINGS MacRoscorre FIGS iver Spleen Ma1ndibular Lymph Node/ dsaaycsrifoifcetrgeratomuenpt:: 2r9ecovery grow 2 aDacceroposfystsatrtaotfitsre:atmpelnutm:ed06z/e10c/e5v0ery 2 dGaatcee ooff ennedceoofpstyreatm|:en0t2:/102/39/811/98 No findings noted No tissues exasined : asaycsrifoifcetrgeratomuenpt:: 2C8ominal sacrifice dnaetceroposfystsatrtaotfutsre:atmpelnatn:ned06t/1e0m/i9n8al ddaattee ooff neencdzoofpsytreatmen0t5:/110/49/011/58 No findings noted Inflammatory cell fot (aintsal) HHaezoopsoitdeesrtisn,pipgrmiesnatril(ysleirghytt)hropoiests (minimal) Lymphoid hyperplasia (slight) HoKidanbenyo/r2m,aliotvaizeys/1f,ouOnvdaziyn/:2,PaAndcrreeansa,l Mdrenal Gland/2, Thyms, Mesenteric KGLiyldsangnehdys/N,le,ds, Mandibular Lymph Node/2. 000409 `PATHOLOGYREPORT Page 105/146 TTeesstt ASrytsitcelme:: ETxEplRoraAtCoCrHOyL/2T0E-LDHaEyR GNaRYvLaAgTeE/Study/PRiUnS/PRIa0Sts PNrOoTpOaXthno.no.: 25432091303 Sponsor + 3MToxicology Services Date + 21.apz.198 Individual Animal Data Records asetx:m vor Fe14asste Dost Grove: AcRosCoPIC FIOTNGS Mcoscoprc FnmINGS Liver Spleen antmal wor 147 acaoscopre FDIS : : ndSaeayccsrroipfofsiycetsrgetarcaamptenut s:+2p0tleamninneadl tsaamcirniaflice ddaactee ooff etnadctofoftrteraetamtemnetn:t:040/81/11/03/890 date of necropsy |: 05/11/38 No findings noted ISinnfgllaemmcaetiolryneccezlolsifsoct(si(nstlmiaglh)t) HHeemmoopsoitdeesrtisn, ppirgimmeanrtil(ysliegrhytt)hropotests (atntmal) NAoKdirdaenbennyao/lr2m,aGlliaOntvdai/re2ys,/lf,oMhuyOnmvdiasri,yn/:2M,ePsaAendncrrteeeanrsai,lc GKliadnnde/y1/,l, Lymph Nods, Mandibular Lysph Node/1, Yandibular Lyeph Nods/2. dSaaycsriofficetrgeraotumpent 2: 0terainal sacrifice ndaetcer'ooprsystsatrtaotfutsre:atmpelnatn:ne0d8/t1a0r/m5i8nal dGaattee ooff nnedczoofpstyreatm+en0t5:/110/43/811/38 Mo findings noted 000410 PATHOLOGY REPORT rage 106/146 TTeesstt ASrytsitcelme:: TExepalorraAtLoCrCHyOL2/8T-EDLaOyR GACaRvYaLgATeE,Stud/yPRUiSn/PRRGaSts PNrOoTpOaXthmo.ho.: 2523903130 Sponsor + 3M Toxicology Services Date. 21.apr.198s Individual Animal Data Records aSnext:eal ve: 1r4e7ste Das Grove: Mrcroscoprc Frwmics Liver Kidney/1 spleen Ma1ndibular Lymph Nods/ etmal Nor Me MACROSCOPIC FIIDINGS. MrcRoscopre PrDIIGS ver Kudnoy/1 Spleen gms : SIinnfgllaemmactelolryneccerlolsifsoct(ai(natianatlm)al) Cystic tudes (sight) Hemosiderin pigsent (slight) Lymphoid hyperplasia (slight) NoOvaarbyn/o1r,malOviatriye/s2,foAunrdenianl: PGlaanncdr/e1a,s,ArKiednnaely/2G,land/2, Nhoydmei/s2,. Mesenteric lymph Node, Mandibular Lysph days of traeaEtment:p20 n rn ndeaccreoposfystsatxtaotfutsre:atmpelnatn:ne0d8/t1e0r/m9i8nal ddaactee ooff neencdroopfstyreatm+en0t5:/101/43/811/38 No findtngs noted Inflammatory cell foct (slight) Interstitial inflamation, lymphocytic (mintnal) HHeemmoopsoitdeasrtisn,pipgraiemnatril(ys1e4rgyht)hropoiesis (minimal) Lymphocyeolysis, increased (sintmal) NOovaarbyn/o1r,malOviatziye/s?,fohurndeoianl: GPlaanncdr/ela,s,MrKiednnaely/2G,iand/z, MMaensdeinbtuelrairc LLyymmpphh NNooddee,/2.Mandibular Lysph Node/1, 000411 PATHOLOGY REPORT Page 107/148 Test Test ASrytsitcelne:: TEexipclMoEraAtLoCOrHyGL2/8IE-LDOaMyR AGaUvIaAgTeE/Study/emiins/eRraosts PNrOoTpOaKthno.no.: 24929003130 sponsor : 3M Toxicology Services Date i 21.pr.1998 Individual Animal Data Records asnetxm:al Nor F1e4m9ale Dost. Grove: MACROSCOPIC FTIDINGS : Mrcaoscopzc Frcs Liver Spleen Fetmal Nor 150 MacRoscopre FDIIGS racRoscoprc FrOIIGS iver Spleen MaTndfbular Lymph Nods/ . dSaaycsriofficetrgersocmuepnt :: 2t9eminal sacrifice ndaatceeoopfsystsatrattuosf treaitmpelnatn:ne0d8/t1e0r/m9i8nal Gdaattee ooff naencdroopfsytreatm|:en0t6:/110/83/811/56 Yo findings noted Inflammatory cell foct (slight) HHaammoopsoitdeesrtisn,ppirgiameantril(ysleirghytt)hropolesis (minimal) NKoidsntooyr/a2a,liOtviaerys/if,ouOnvdaciyn/:2,PanAcrreenaas,l KGliadnnde/yl/,l, AMdarnedniablulaGrlanLdy/m2p,h TNoydem/1,, MMeasnednitbeurliacr LLyyssgphh NNeoddse,/2. sdaaycsriofficetrgeraotpment:: 2t9eminal sacrifice nGaatceroposfystsatrtatofutsre:xtapslnatn:ne0d8/t1e0r/m9i0nal daattee ooff annedcroofpstyreatm|:en0t6:/110/53/811/98 No tintags noted HIenmfaltaompmoaiteotriyc cceellll ffooccki (s(laiignhits)al) Hemosiderin pigeant (moterate) LyPslapshmoalcdythoyspiesrp(lsalsigihat)(slight) 000412 PATHOLOGY REPORT rage 108/146 TTeesstt ASrytsitcelme:: Sponsor i TE3exMipcTlwoEonxriaActLooClrOoyHgOLy2/6TS-EeDIraEvyRicAGeaRsvAaTgEe,Stud/yeRiiSn/PRicasts| DNPaOrtTeoO.pKathmo.no.:: 21.apz2.49125880931930 FE -- Zndividual Animal Data Records : seAnxt:al we: 1F5e0nate Dose Grou: M(recoRnocsicnoupedr)c FwmIGs Atma wer 151 MacRoscoPIC FDIC veerus MICROSCOPIC FrOINGS iver veers spleen NoKidanbenyo/r2m,aliOtvaireys/lf,ouOnvdariyn/:2,PanAcdrreeansa,l KGliadnnde/yL/,1, MMdacnedniablulaGrlanLdy/m2p,h TNhoydmei/s2,. Mesenteric Lysph Neds, dSaaycsrifoifcetrgeraotpment:: 2t9eminal sacrifice DGaetceroopfsystsatrtaotfutsre:atmpelnatn:ned08t/1e0r/m9i8nal ddaattee ooff neencdroopfsytreatm+en0t8:/110/53/811/33 ese std cysts) Notisssuhes enxamoinedrverme foaundlinianytofitheeotsher mflamatory call foot (slight) CFyisntdsi)ng)present simple serosal) (correlates to GROSS Hemosiderin pigment (slight) NoAKdiradenbonnyao/rl2m,aGllOaivntadir/ey2s/,lf,fohuyOnmvdiasci,yn/:zM,ePasAnecdnrcteeeanrsai,hc KLGliyadmnnpdeh/yl/N,lo,de, Mandibular Lymph Node/1, Mandibular Lymph Node/2. 000413 PATHOLOGY REPORT rage 103/146 TTeesstt ASrytsitcelme:: ETxepolohraAtLoCrOyRL2/0T-EDLaEyR GMaAYvIaNgTeE/St|ud/yPNiSn/erRoasts PNrOoTpOaXtnho.no.:+ 24525903130 Sponsor i 3M Toxicology Services Date 21.apr.isss Individual Animal Data Records seanxi:mal vor 1T5e2ale Dos Grow: acRoscopc PIGS MIcRoscopIC FRDINGS Liver Kidney/1 spleen ym ntmal No: 153 MACROSCOPIC PIDIGS Microscope FIOIIGS dSaaycsrifoficetrgeraomuepnt :: 2t9eminal sacrifice ndaetceroopfsystsatrtaotfutsr:eatpulenatn:ne0d8/t1e0r/m5i8nal GGaattee ooff neencdroopfstyr|eatmen0t/s110/53/811/38 No findings noted SIinnfgllaemmcaetlolryneccorlolstfsocl(si(nattmnailz)al) Tubular atrophy, cortical (minimal) HHuemmoopsoitdeesxtisn,ppirgimmeanrtil(ysleigrhytt)hropoiesis (minimal) Lymphotd atrophy = drvelution (sinimal) NOoMveasazebynn/to1er,rmiaOclviatLziyyem/sp2h,fNoAouddnerd,enianM:lanGdPliaabnnucdrl/ealar,s,LMyazKpiedhnnaeNlyo/d2eG,/i1a,nd/2, Mandibular Lymph Node/2. dsaaycsriofficetregartampent 1: 2r9ecovery grow dnaetcaroposfystsatztaotfutsre:atmpelnatn:ed08r/1e0c/o9v8ery daattee ooff neencdroopfstyreatm+en2t0:/110/53/811/98 No findings noted Mo tissues examined 000414 `saHoLOGY REPORT rage 110/146 TTeesstt ASrytsitcelme:: TExepulonraAtLCoOrHyOL2/T-TDIaOEyR GAaRvAagTeESt|ud/yPRiSn/ERRasts PNrOoTpOaXthmo.no: Sponsor + 3M Toxicology Services Date t+ 24925903130 21.2pr.1s99 t eee eeeee eee n Individual Animal Data Records : asneix:mal wer 1T5e4ale Dose Grove: MacaoscoPrc FDINGS MacRoscoPIC FINDINGS eteal wo: 155 cRoscorte FromIGs MICROSCOPIC PINDINGS. Jatsal No: 157 MACROSCOPIC PIIDINGS dSaaycsrifofictsrgeraotwment: 2E9acovery group nGeactreoposfysstattatofutsre:atpmelnatn:ed06r/1e0c/o3v8ery GGaattee ooff amnedczoofpsytreatm+en2t0:/110/53/811/98 Yo findings noted No tissues examined dSRaaayccsrroipfofsiyctersgetaramoetnuutps:: 2r9ecovery group planned recovery GGaattee ooff e`sntdarotfoftrtesrtemaetnmte:nt:050/181//1908/58 date of necropsy + 20/11/98 Yo findings noted No tissues examined dSaaycsriofficetrgeraoutpment: r2e9covery grow 2 PGaatcacoopfsy`sstatrtatofutsre:atmpelnatn:ned08s/e1c0/o3v0ery 2 ddaattee ooff neencdroopfstyreatmen0t4:/120/53/811/38 No findtags noted 000415 PATHOLOGY REPORT rage 111/146 TTeesstt ASrytsitcelme:: TExEpLloAraAtCoOrOyLT2E8-LDOaGyR AGaRvNagEe]Stud/yPTiiSn/eRroasts PNrOoOpKathno.no.: 23432091303 Sponsor i 3M Toxicology Services Date : 21.2pr.1999 Individual Animal Data Records asneix:mal vo: T15e7ale Dose Group: MICROSCOPIC PIDINGS Antal vo: 138 croscopte PromIGS MICROSCOPIC PODTNGS animal vo: 159 McRoscopre FrDIIGS MrcRoscoprc FrwmiGs Ho tissues examined dSaaycsriofficetrgearcmoenutp:1 2r9ecovery group 2 ndaetceroposfyscsatreaotfutsre:atmpelnatn:ned08r/1e0c/o9v8ery 2 Gdaattae ooff anencdroofpstyreatm+en0t4s/120/59/811/90 No findings noted Ho tissues examined dsaaycsrifoifcetrgesrmoenutp:: 2r9ecovery grow 2 nGeactreoposfystsatrtaotfutsre:atmpelnatn:ne0d0/r1e0c/o9v8ery 2 Gdaattae ooff naencdroopfstyreatm+en0t4:/120/59/011/98 No findings noted No tissues examined 000416 PATHOLOGY REPORT TTeesstt ASrytsitcelme::THELxOpMlEoRrAaCtOoHrOyL/T2E8L-ODMaIyR GACaRvYaLgATeE,Study/eRiins/eRracsts Spemsor + 3M Toxicology Services Page 112/146 PNrOoTpOaKthno.no.: 24923003130 Date. 21.pr.1999 Individual Animal Data Records Seaxtm:al Nor a65le Dose Grove: pus MacRoscopte FmDINGS MacRoscorze FIDINGS Iver. idney/1 Spleen taal Wo: 66 MACROSCOPIC FIDIIGS sng Stomach Testes sdaaycseifoifcetrgeraotupment:: necropsy status: pt2l0eamninneadltseascmriinaflice ddaattae date ooff of nesetncadrrotopfsoyftretartema+ecna0ta3:n/c1:01/29/08161//190/098 No findings noted MISiindnfzglolanemamlcaetcloelrnytnrecicalrlolobsuiflsoatr(ahi(ynspiieagrahltt)r)ophy, diffuse He(poadtaozcaetlel)ular vacuolation (slight) Tubular atrophy, cortical (minimal) Hamopotesis, primarily erythropoiesis (slight) NToesatbenso/r1m,alTietsiteess/f2o,unAdrienn:alPanGclraenads/,i, KiAddnreeyn/a2l, Gland/ N2,odeT/h1y,musM,anMdeisbeunltaerriLcympLhymNpohdeN/od2e., Mandibular Lymph Sdaaycsrifoifcecrgeraomuepnt : c20aminal sacrifice dneactreoposfystsatrtaotfutsre:atapelnacn:ned06t/e10r/m9i5nal ddaattee ooff nenedcorfotprseayt:men0t3:/110/29/811/93 Hemozzhage Glandular micosa Hemorrhage Reduced in size 000417 `PATHOLOGY REPORT Page 113/146 TTeesstt ASrytsitcelme:: TExepilonraAtLCoCrHyOL/2T8E-LDGHaEyR GNaRYvLaAgTeL/Stud/yRRiiSn/eRiaosts PNrOoTpOaXthno.no.: 24523003130 Sponsor + 3M Toxicology Services Date : 20.pr.19%s Individual Animal Data Records : aSext:m Yor H6a6le Dost Grove: pus M(ccronotsicmoupsrd)c FrmINGS Epidiaymides Reduced tn stze NUosasbuneosrmaelxiatmiiensedvere found in any of the other " wxcnoscorrc roms zngs In(tcroar-raellvateeoslartoblGoRoods,S nEeicndrionpgs)y artefact present Vascular mineralisation, focal (intemal) semen ver Pancreas No micro correlate MIindfzloanmamla/tcoernytrcielllobufloacr h(yapienrtceraolp)hy, diffuse (moderate) poptosis/single cell necrosis, exocrine (minimal) Kidney/1 Tubular atrophy, cortical (minimal) Tostes/1 Testes/2 SGeRmOtSnSifefrinoduisngt)ubular atrophy (severe) (correlates to SGeRmotsnsiferinoduisngt)ubular atrophy (severe) (correlates to Eplataynides AAstpreorpmhiya (pmroedseernatte) (corzelates to GROSS finding) Spleen HHaemmoopgoitdeesrtisn,pipgraiemnatril(yatenirsyatlh)ropoiesis (sinimsl) Ma1ndtoular Lymph Node/ Ma2ndlolar Lymph Nods/ Plasmacytosis (moderate) Congestion/erythrophagocytosts (intzal) N1o, aAbnroemnmaalldtGliaensd/f2o,unTdoyimni:s,KiMdneesye/n2t,erAidcreLnyamlghGNloadned./ 000418 PATHOLOGY REPORT Page 114/146 TTeesatt ASrytsitcelme:: ETexLpclHEoRraAtCoOrWyOL/2T8E-LDOaMyR AGCaRvVaIgATeE/Stud/yePiiSn/eRrcasts PNrOoTpOaKthmo.no.: 24525903130 Sponsor + 3M Toxicology Services Date. + 21apr.1999 Individual Animal Data Records seAxt:al Net H6a7le Dost croup: prs McRoscorte FrwIGS `MrcRoscoptc FrwIGS ver Kdnoy/1 Spleen Ma1ndlblar Iysph Node/ rotmal Nor 60 acroscoptc FromiGs dsaaycsrifoifcetrgeraotpment:: t28aminal sacrifice Bdeactreoposfystsatrtaotfutsre:atmpelnatn:ed06/t1e0r/m5i8nal Gaactee ooff enencdroofpstyreatm+en0t3:/101/25/811/98 No findings noted MISinidfnzlgoalnmeamlcaetcloelrnytnrecicelrloolbsuiflsoaorl(mh(iysnplteiarglth)rt)ophy, diffuse CHoe(apmgaoutdloeacrtaetilevl)uelanrecvroasctuso,latfioocnal (m(imniinsiamla)l) Tubular atrophy, cortical (minimal) Hemopotesis, primarily erythropolesis (slight) Plasmacytosis (slight) NoT2,esatTbehnsyo/mr1um,sa,lTieMtseitseesesn/ft2oe,urniAdcdrLieynn:maplhPaGNnolcdarene,dss/,iM,anKAdidirubeeunyla/a2lr, GLlyamnpdh/ Nodo/2. dSaaycsrifofictergeraotpment:: t20aminal sacrifice dDaetceropofsystsatrtaotfutsre:atmpelnatn:ne0d6t/e1r0/m5i8nal ddaattee ooff ennedcorfotprseyat:men0t3:/110/29/811/98 No findings noted 000419 `PATHOLOGY FZRORT rage 116/146 Test Test ASrytsitcelme:: TEExLpOlEoRrAaLtOoIrGyL/2TE8L-ODMaEyR GACaRvYaIgATeE/StudyPTiInS/eRraosts Sponsor 1 3M Toxicology Services PNrOoTpOXatnho.no.: Date' i 24`325003130 21.2pr.1998 Individual Animal Data Records tsanx:a No: r6a9te Dosk Grove: pus (accornotsincuoerdz)e FIXDIGS rtm wo: 70 McROSCORIC FIRDINGS MrcRoscopre FDIS ver Pancreas Kidnoy/1 Spleen : . No`Taasbtneosr/1m,alTietsiteess/f2o,unAddrien:nalPaGnlcraensds/,?, KiTdonyemiys/,Z, MMeasnednitbeurliacr LLyysmgphh NNoodde,/2.Mandibular Lymph Node/1, dSaaycsrifoficeexegartampenc :: 2t9arsinal sacrifice DGaaccreoposfystsatrtaotfutsre:atmpelnatn:ed06t/e1r0/m3i8nal dGaaccee ooff enencdzoafpstyreatm+en0t4:/130/35/811/58 No findtngs noted MSIiindnfzglolanemamlacte[olclreynnterccierllloosbuiflsoacrt(ahi(ynsptlemiarglth)tr)ophy, diffuse (slight) In(faltanmtmzaatl)ion, mixed granslocytic/lymphocytic Interstitial inflamation, lymphocytic (minimal) Hemopodasts, primarily erythropoiesis (slight) No`Taasbtneosr/2m,alAidtcieensalfoGulnadndi/n1:, KAidrueenya/2l, GlTaensdt/e2s/,l,Thymss, MMeasnednitbeurliacr LTyymmpphh NNooddeo,/2.Mandibular Lymph Node/1, 000420 `PATHOLOGYREPORT Page 117/146 TTeesstt ASrytsitcelme:: TErxpolmoaraAtCoHrOyL/2T8E-LDOaEyR GAaCKvIaNgTeE/St|udPyRAiYn/MROaSts PNrOoTpOaKthno.no.: 20925003130 Sponsor + 3M Toxicology Services Date. 20.Apr.1999 Individual Animal Data Records : Jsaetx:mal Nor aTLle . Dosk Group: FHS MACROSCOPIC FINDINGS dSaaybsrifofictergeraotwment:: 2t9eminal sacrifice ndaetceropofsystsatrtatofutsr:eatmpelnatm:ned06t/e1r0/m5i8nal daactee ooff ennedcroofpstyreatm|:en0t4:/1013//3181/98 No findings noted MrcRoscoprc FING Liver SIinnfgllaemmactololryneccerlolsifsoct(mi(nsilmiaglh)t) Midzonal/centrilobular hypestzophy, diffuse (slight) Kidney/1 Cystic tues (shighe) Spleen HHeenzoopsoitdeesrtisn,'ppirgiazeanrtil(yatenrizyatlh)ropoiesis (aintaal) Ma1ndibular Tysgh Node/ Plasmacytosts (slight) Ma2ndioular Typh Nods/ Plasmacytosis (slight) NToesatbenso/mlm,aliTetsiteess/f2o,unMdrienn:alPanGclraenads/,i, KAidrneenya/2l, Gland/ ` 2, Thymis, Mesenteric Lysph Node. Atma wo: m2 cRoscopre PImINGS dSaaycsrifoifcecrgeartmoenutp:12t9erminal sacrifice ndaetceroposfystsatrtaotfutsre:atmpelnatn:ne0d6/t1e0r/m9i8nal ddaattee ooff neencdzoopfaytreatmen0t4:/110/39/811/38 Liver larged 000421 `PATHOLOGY REPORT Page 119/145 TTeesstt ASrytsitcelme:: ETexLpaluonraMtCoOrHyOL2/0T-EDLaGyR GAaRYvLaAgTeE/Study/ORiInS/ERIa0Sts PNrOoTpOaKthno.no.:+ 20925903130 Sponsor + 3K Toxicology Services Date. + 21.apr.1988 Individual Animal Data Records rSeax:ta vor a7le Dost Grove: pus acRoscopre FIDIIGS Tastes `MICROSCOPIC FIDINGS Liver estes/1 astess2 ratmal vor 78 McRoscopre FnmINGS . `McRoscope FDIIGS Liver sdaaycsrifoifcetrgeraomuepnt :: Decropsy status: pr2l9eacnonveedrysegcroovuery daaccee'oofs setnadroefotfretartemaetnetn:t:03/0161//1908/50 ante of neczopay |: 18/11/% Reduced in size NoUsarbuoessaxelxdatmiiensedwere found in any of the other ISinnfgllaemmcaetlolryneccazlolsifsoci(mi(nsilmiaglh)t) SeSomiGnRiofsesroufsindtiunbgu)lar atrophy (moderate) (correlates Se"0mtnGriofsesroufsindtiunbgu)lar atrophy (moderate) (correlates dsaiycsrifoifcatrgescrmeantp:1 r29ecovery grow ndaatceeoopfsystsatrtaotfutsre:atmpelnatn:ed06/r1e0c/o9v8ery ddaattee ooff neencdroopfsytreatmen1t6:/110/39/811/98 Yo findings noted MISiindnfzglolanemamlcaetcloelrnytnrecicalrloolbsuiflsoacir(ahi(ynspilesiarglth)rt)ophy, diffuse (iniaal) 000422 `sAHOLOGY REPORT Page 120/146 Test Test ASrytsitcelme::TEoxpolnoraAtLoCrOyHL2/0T-SDLaGyR GAaRvIaAgTeE/St_ud[yeRiiSn/eRroasts PNrOoTpOaXthno.Ro. 24925903130 Sponsor i 3M Toxicology Services Date. t 21.Ape.1999 Individual Animal Data Records SJxat:mal No: 7a7le Dost Grou: prs MacRoscopIc FomGS MrcRoscopre FNDINGS ztver atmal ver 78 acRoscopIC PIKDIIGS. MrcRoscopIc FINDINGS. Liver ratmal Ne: 79 MacRoscopze PDIIGS dSaaycsrifoifcetrgeraowtpment:: 2r9ecovery grow 2 nGeacceropoafystsatrattisof treaitmpelnatn:ne0d6/r1e0c/o9v8ers 2 ddaactee ooff neencdzoopfaytreatm+en0t2:/120/39/011/98 . No findings noted SIinnfgllaemmcaetlolryneccerlolsifsoci(si(nsilniaglh)t) dSaaycsrifoifcetregarmomwent :i 2r9ecovery grow 2 ndaetcaroopfsystsatrtaotfutsre:atmpelnatn:ned06r/1e0c/o3v8ery 2 ddaattee ooff ennedcroofpstyr|eatm+en0t2:/120/39/811/98 Mo findings noted SIinnfgllaemacteolrlyneccerlolstfsoct(ai(nstlaiaglh)t) dSaaycsrifoficetrgreomupens:i 2r9ecovery grow 2 RGaetceropoafystsatrattisof treaitupelnatn:ne0d6/r1e0c/o3v8ery 2 ddaaccee ooff neencdroopfstyreatm|:en0t2:/120/39/811/98 000423 `SATHOLOGY REPORT rage 121/146 TTeesstt ASrytsitcelme:: ETxEpLlEoRraAtCoOrHyOL2/0T-EDLaOyR GAaRYvLaAgTeE/Stud/yeRiisn/eRrcasts PNrOoTpOaXthmo.no.: 24925903130 Sponsor:3M Toxicology Services Date t+ 21.Apr.1999 Individual Animal Data Records Asenxtal wor a79le Dost Grove: prs M(accoanotsicnioepdr)c FIGS MrcRoscopte FrmIGS - ver aSonxt:aa we: F1e61male MACROSCOPIC FINDINGS HrcRoscoRze FIDINGS Liver Kidney/1 : spleen No findings noted IHnefplaatmomcaetlolruylacrevllacufsocitati(osnligjhati)ntmal) dsaaycsrifoifcetrgeraoutpment: 2t8erminal sacrifice ndaetceroposfystsatarttusof treaitmpelnatn:ne0d8/t1e0r/m9i8nal ddaattee ooff nenedcorfotprseyat:men0t/:110/49/811/38 No findings noted : Inflammatory cell foot (slight) Tubular epithelial hypertrophy, focal (minimal) HHeemmoospiodteersitns',pipgrimmeanrtil(ysleigrhytt)hropoiesis (atntmal) N`oOvaabznyo/r1,malOivtaiersy,foAudnedenian:l GPlaanncdr/e1a,s,MrKiednnaely/zG,an/2, TNnoydmei/s1,, Maansdeinituelraizc LLyymmpphh NNoodde,/2.Mandibular Lymph 000424 `PATHOLOGY REPORT rage 122/145 TTeesstt ASrytsitcelme:: ETExLpGlEoRxaAtCOoHrOyL/2T0E-LCDWaEyR GACaRvYaIgAeTE/Stud/yPRYiSn/PRRGaSts PNrOoTpOaXthno.no.:+ 24325903130 Sponsor: 3M Toxicology Services Date. 2Lapr.isss Individual Animal Data Racords Asunxt:al we: F1e6m2ale Dost Group: BES. .cRoscoprc FIimONGS MrcRoscoPrc FnmINGS Laver spleen Aotmal No: 163 MacRoscopre FrmmGS dSaaycsrifofictergeracomwen 1: t28eminal sacrifice dneactreoposfystsatarttusof treaitbpelnatn:ne0d8/t1e0r/m9i0nal ddaattee ooff nenedcroofpsytr|eatmen0t8:/110/49/811/98 No findings noted SIinnfgllaemmcaotlolryneccorlolsifsot(si(nsilniaglh)t) HHeemmoopsoitdeesriisn,pipgrmiemnatril(ysliegrhytt)hropoiesis (atninal) YoKidanbenyo/r2m,alOivtaizeys/1f,ouOnvdaciyn/:2,PaAncdrzeesnsa,i KGliadnnde/y1/,l, MAarnedniablulGalranLdy/s2p,h NTohdyem/i1s,, MMaensdeinbtuelrairc LLyymapphh NNooddee,/2. dSaaycsrifofictergeraoutpment:: t20eminal sacrifice dnaetceroposfystsatzattuosf treaitmpelnatn:ned06t/e1r0m/i9n8al ddaattee ooff neencdroopfstyreatm+en0t5:/110/43/811/90 No findings noted 000425 `PATHOLOGY REPORT rage 123/148 TTeesstt ASrytsitcelme:: TEexLpalmoRraAtCoOrHyOL2/0T-EDLaRyR GAaRvAagTeEStud/yeRiiSn/eRioasts PNrOoTpOaKthno.Ro.:+ 29052091303 Sponsor i 3M Toxicology Services Date. 21.2pr.1999 Individual Animal Data Records Asetx:ma vor 1T6e3ale Dose Grove: pms `McRoscoprc FrwmiGs iver Spleen gms MaTndltalar Lymh Node/ Jatmal vor 164 McRoscoste FIDINGS MrcRoscopre FrDIGS Liver Spleen hymn + ISnifnlgalmemacetlolryneccerlolsifsock(ai(nmtemdaalr)ate) HHoenmoapsoitdeesrtisn,pipgrmiemnatril(ys1eigrhyet)hecpotesis (slight) Lympbocytalysis, increased (mintsal) Plasmacytosis (slight) NMoKirdaenbnenayol/r2m,GallOaivntadi/ze2ys,/lf,HoausOnevdnaitrnay:r)i,psaAnLdcyzrmeepanhsa,lNodGKeli,adnndeM/ya1/n,ld,ibular Lysph Node/2. dSaaycsrifoficetrgeramaepnt 2: 0teminal sacrifice dnaetceroposfysstatrtatofutsre:atmpelnatn:ned08/t1e0r/m9i8nal ddaattee ooff ennedcroofpstyreatm|:en0t5:/110/43/811/38 No findings noted Inflammatory coll foc (slight) HHeemmoopsoitdeesxiisn, ppirciaemnatril(ysliegrhytt)hropoiesis (sintmal) Lysphotd atrophy - involution (sight) NAKodirdaenbnenayo/lr2m,aGllOainvtdai/re2ys,/lf,MoeusnOevdanztiyen/:r2i,cpaAnLdcyrraeeganhsa,lNodKGeli,adsndeM/yal/n,ld,imulas Lymph Node/1, Mandibulax Tysph Node/2. 000426 PATHOLOGY REPORT rage 124/145 TTeesstt ASrytsitcelme:: ETxEpEloNraAtCoOHrOyL/2T0E-LODHaEyR GACaRvYaLgATeE,Stud/yeriWn/eFrasts PNrOoTpOaXthmo.fo.: 24525003130 Sponsor: 3M Toxicology Services Date : 21.apz.135 Individual Animal Data Records : REtxm:al vo: F16e5male DOSE Grove: BS. acroscoprc FrwmiGs srcaoscoprc FnmmGs Liver Pancreas Spleen Mntaal No: 165 acRoscoprc FmiGs ndSeaacycrsroipofsfiycetsrgteaartmuoesnutp:i: 2t9eminal sacrifice planned terminal Gdaattee'oofe date of ansentcdaztoofpoaftyr|etartemaetnm0ce6:n/t1:10/59/08101//1906/98 No findings noted IStnofgllaemmcaetlolryneccerllosifsoci(ai(nmiimnailm)al) Apoptosts/single cell necrosis, exocrine (minimal) HHeeszoopsoitdeesrtisn,pipgrimmeanrtil(ysliegrhytt)hzopotesis (stnizal) YOovaarbyn/oir,malOviatriye/s2,foAudnrdenina:l GKliadnnde/yl/,1,NdKridenneayl/2G,iand/z, NTohdyem/i1s,, Measnednitbeurliarc Llyymmpphh NNooddee,/2.Mandibular Lyaph dsaaycsriofifcatrgeartmoenutp:: 2t9erminal sacrifice dnaetceroopfsystsatrattusof trea:tmpelnatn:ned00/t1e0r/m9i8nal ddaattee ooff neencdzoopfsytreatm|:sn0c6:/110/53/811/38 No findings noted 000427 PATHOLOGY REPORT Page 125/148 TTeesstt ASrytsitcelme:: TEExLpclHoRraAtLCoOrIyOL2/8T-ELDOaGyR GAaCRvYaLgAeTEStud/yPPiiSn/eRraosts PNrOoTpOaKthRo.no.:t 2492001303 Sponsor + 3M Toxicology Services Date 202pr.199 Individual Animal Data Records SJeoxtmal No: Z1e6a6xle Dost rove: pHs. MrcRoscopte FIDOGS Liver zens Gland/1 Spleen MaTndtiler Zymeh Nods/ etna vor 167 MacRoscoRze FDIS MacRoscorze FmmINGS Liver Spleen . Inflammatory call foot (sintmal) Extzacapsulas nodule present HHeemmoopsoitdeesrtisn,pipgrmiemnatcil(y31sigrhytt)hropotesis (aintzal) Lymphoid hyperplasia (slight) NoKidanbenyo/r2m,aliOtriye/slf,ouOnvdariyn/:2,PaAncdrceesnsa,i GKliadnnde/yz/,l, NTooydmoi/s2,. Mesenteric Lymph Nods, Mandibular Lymph dSaaycsrifoifcetrgeraoutpment:: t29aminal sacrifice odaccreoposfystsatrtaotfutsre:stzpalnatn:ned00/t1e0r/m5i0nal ddaactee ooff neencdzoopfsytreatm+en0t6:/101/59/811/98 No findings noted SIinnfgllaemacteolrlyneccerllosifsoci(si(nmiinnailm)a) HHoemmoopsoitdeesritsn,ppirgimemnatril(ysleigrhytt)hropolesis (minimal) NoKidanbenyo/r2m,aliOtvaireys/lf,ouOnvdartyn/:2,PaAndccreenaasi,. Mrenal Gland/z, Thymis, Mesenteric GLKlyiasdnnpdeh/y1/Nll,o,de, Mandibular Lymph Node/1, Mandibular Lymph Node/2. 000428 PATHOLOGYRepo rage 126/148 TTeesstt ASrytsitcelme:: TExepilonraAtLoCOrWyOL2/8T-ELDOaGyR GACaRvYaLgATeS/Study/Sin/PRoasts PNrOoTpOaXthmo.no.: 242033 59010 Sponsor + 3M Toxicology Services Date t+ 21.Apr.1999 Individual Animal Data Records Asunxt:al wo: 1F6e9male ost Group: prs MacRoscoPIC FDIS rcRoscopre PomGS Liver. Kidney/1 spleen animal wo: 169 MacRoscopIC FrDIGS Macroscopze price dSaaycsrifoifcetrgeraoutpment:: 2t9eminal sacrifice dnaetceroopfsystsatrtatofutsre:atmpelnatn:ne0d0/t1e0r/m9i0nal ddaattee ooff ennedczoofpstyreatmen0t6:/110/59/811/30 No findings noted . ISHeinpnfagltlaoemcmeacletllolurlynaecrcervloalsciusfo.olcal(tsii(onaniiznat(lms)ailn)imal) Cystic tues (atntnal) HHeezmmoopsoitdeesrtisn,pipgrisaeanrtil(yzoedreryatther)opoiesis (ninizal) NO`ohvyaamzbiyns/o,lr,mMaelOvisaterinyet/se2r,ifcoAudnLrdyemnptanh:lNoGPdlaean,ncdr/eY1aa,sn,dAidbKirudelnanerayl/LZyG,slasnhe/z, Node, Mandibular Lyseh Node/2. dSaiycsrifoficetrgeratomuenpt:: r29ecovery group ndaetceroposfystsatrtaotfutsre:atmpelnatn:ned08r/e10c/o9v8ery ddaattee ooff nenedcorfoptrseyat:men2t0:/110/59/811/98 Wo findings noted Ho tissues exantned 000429 `PATHOLOGY REPORT nage 127/145 Test Teat Article: System : TEExLpMlEoRraAtLoCOrWyOL2/8T-ELDOaMyA GAaCRvLaNgTeL/Study/PiAnS/PROaSts PNrOoTpOaKthno.no.:: 24929003130 Sponsor + 3M Toxicology Services Date i 21.2pr.1999 Individual Animal Data Records asnmt:ead wor 1r7e0ale Dos Gove: ers MacRosCoRIC FIDINGS `acroscopze FrwIGS Fatma vor 17 Macroscorte FIONIGS MacRoscopre FIGS rtm wor 173 MACROSCOPIC FINDINGS dSaaycsriofficeergesrcmoenut p: necropsy status rp29leacnonveedryregrcoouvpe.ry ddaattee ooff satnadrtofotfretartemaetnaten:t:050/181//1908/58 cate of necropsy |: 20/11/38 No findings noted No tissues examined dsaaycsriofficetrgesrmoenutp:1 2r9ecovery group. nddeaacttreeopoosffysesntdattoaftotfuretsarte:maetnmpteln:atn:n0e5/d0181r//e13c08/o9v0ery cata of necropsy |: 20/11/98 No findings noted No tissues examined dSaaycsrifofictergeraotwment: r29ecovery grow 2 nGaetceropofsystsatrtatofutsre:atpmelnatn:ed00r/1e0c/o5v8ery 2 aGattee ooff ennedcroofpstyreatm|:en0t4:/120/55/811/58 No findings noted 000430 PATHOLOGY REPORT rage 128/146 TTeesstt ASrytsitcelme:: TErxpileorraAtLCoOrHyOL2/8TE-LDOaNyR GMaYvaLge)Stud/yemsisn/pRroasts PNrOoTpOaXthno.mo.:+ 24925003130 Sponsor: 3M Toxicology Services Date t 21.apr.1995 Individual Animal Data Records : ASeoxt:na vo: 1e7a3sle Dost row: brs. MacRoscopre FImDGS aatmal wor 174 Mcroscorze FDIS MrcRoscopre FDIS ratmal wor 178 caoscopre FDIS : McRoscope FrwmGs No tissues exaained dSaaycsriofficetrgeratomuenpt:: necropsy status: r2p9elcaonvneerdyxagcroovwer2y 2 ddaattee ooff estnadrtofoftretartemaetnmte:nt:08/0161//1908/99 date of neczopsy 04/12/98 No findings noted No tissues examined dsaaycsrifoficetrgeratomuenpt:: r29ecovery grow 2 dnaecceropofaysstatrtatofutsre:atmpelnatn:ned06r/1e0c/o3v8ery 2 ddaactee ooff enencdroopfsytreatmen0t4:/120/59/811/93 Mo findings noted No tissues examined 000431 `sAmoLoGY RESORT Page 123/146 TTeesstt ASrytsitcelme:: TEexpolmoaraAtCoOrOyL2/0T-EDaOyE Gaavvaigse)Stud[yemiisn/eRroasts PNrOoTpOaXthno.no.:+ 24525003130 Sponsor: 3M Toxicology Services Date : 21.apr.9s Individual Animal Data Records : rseax:ta vor a1te Dose Group: pros MacRoscope PmIGS MrcRoscoprc FrwIIGS iver Kidney/1 Spleen MaTndibular yeh Node/ Animal vo: 62 cRoscoPrC FROIGS : sdaaycsrifoifcetrgesrtmoenutp:: t20erminal sacrifice ndeactreoopfsystsatrtatofutsre:atmpelnatn:ne0d6/t1e0r/m5i0nal ddaactee ooff neencdroopfstyreatmen0t3:/110/29/811/98 No findings noted MSIiindnfzglolaneamlactecolelrnytnrecicelrloolbsuiflsoacrt(shi(ynspilemiragtlht)r)ophy, diffuse (slight) Hematopoiatic cell foot (Binimat) Tubular atrophy, cortical (atntzal) HHeemmoopsoitdeasriisn,plpgroiemnatril(yatenrizyatlh)ropotesis (sintmal) Plasmacytosis (moderate) MToesacberso/r1a,aliTtesiteess/fzo,unAddrien:nalPaGnlcarnedss/,i, KAiddrneenya/2l,Gland/ N2,odTehsy.mus, Mesenteric Lymph Neds, Mandibular Lyrgh sdaaycsrifoifcetregartomwent i: t28erminal sacrifice dnaetceroopfsystsatrtatofutsre:xtmpelnatn:ned06/t1e0r/m9i0nal ddaactee ooff nenedcorfotprseayt:asn0t3:/110/29/811/98 No findings noted 000432 PATHOLOGY REPORT TTeesatt ASrytsitcelme:: TEExLpOlHEoRraAtCoOMrOyL/2T8E-LODNaEyR GACaRvVaLgATeE/Stud/ymiisn/erRoasts Sponsor 1 3M Toxicology Services rage 130/146 PNoOpTOaXthno.ho.: 20925003130 Date. 212pr.1999 Individual Animal Data Records ' rSaEt:mal ve: v8a2le DosE Grove: Bros rcroscoprc Proms Liver Pancreas Kdnoy/1 Spleen etm vo: 83 MaCRoscoprC FrDTNGS { Mcoscoptc FrwmiGs Liver Kidney/1 Kidnoy/2 MIindfzleanmaadtcoernytrciollolbufloacrt (moderate) h(yspleirgchtr)ophy, diffuse Hepatocellular vacuolation (aintsal) Apoptosts/single cell necrosis, exocrine (slight) Tubular atrophy, cortical (aintnal) HHaeszmoospiodteersiins',pipgrmiemnatril(ymienrimyatlh)ropoiesis (minimal) NHToeessatebennsot/re2mr,ailciAtdLciyeemnspahlfooGudlnsad,ndi/Mnl:a,nKdiAiddbnrueelyna/ar2l,LGylTmaepnshdt/eN2so,/dle,/F1h,yms, Manaibilar Lymph Node/2. Sdaaycsrifoifcetrgeraotwment:| t28erminal sacrifice dnaatceeoposfystsatrtaotfutsre:atmpelnatn:ned06/t1a0m/m9i8nal ddaattee ooff nenedcorfoptrseyat:men0t3:/101/23/811/38 No findings noted SIinnfgllaemacteolrlyneccerlolsifsot(mi(nsilmiaglh)t) MHie(dpezaootdnoeaczlaetlcele)unltarrilvoabcuuloalratihoypner(tmrionpihmya,l) diffuse CIynstteircstittuibaullesinf(lsalmimgahtt)ion, lymphocytic (slight) Interstitial inflamation, lymphocytic (minisal) 000433 PATHOLOGY REPORT Page 132/146 TTeesstt ASrytsitcelme:: TEoxipaleonraAtLCoOrHyOL2/6T-ELDOaGyR GACaRvYaLgATeE,Study/PRiUnS/RERasts PNrOoTpOaKthno.ho.:+ 24529003130 Sponsor + 3M Toxicology Services Date 210x199 Individual Animal Data Records sADeaoxts:mEalGaowoure: ap84rtoes `(Wccornotsicnuoepdt)e FromiGs ratmal Nor 85 McRoscoste FDIS MrcRoscoprc FwmiGs iver Kidney/1 spleen animal wor 96 MACROSCOPIC FINDINGS NTMoeasnatdbeinsbo/rulml,aalriTteLsiytemaspsh/f2No,oudneTd/h2yi.mni:s,PaMnecsreesnst,eriKcidnLeyym/pzh, Node, dSaaycsriofficetrgeraotwment:i 2t9erminal sacrifice dnaetceroopfsystsatrtaotfutsre:atmpelnatn:ne0d6/t1e0r/m5i8nal ddaattee ooff neencdroopfstyr|eatm+en0t4:/110/33/811/98 No findings noted MIindfzloanamlatcoernytrciellolbufloacrt h(ympienritmraol)phy, diffuse (nodozate) Tubular atzophy, cortical (minimal) Hemopotests, primarily erythropoiesis (atnimal) N`oTeasbtneosr/ml,aliTtaisetass/f2o,unAddsine:nslPanGclraenads/,i, KAiddnroeyn/aZl, Gland/ N2,odeT/h1y,musa,ndMiebsuelnatreriLcyspLhyspHhodNee/d2s., Mandibular Lymph dsaaycsrifoifcetrgeraowtpment:: 2t9eminal sacrifice ndaetceroposfystsatraetusof treaitmpelnatn:ned06/t1e0r/m9i8nal dGaattee ooff ennedcorfoptrseyat:men0t4:/110/33/811/30 000434 `PATHOLOGY REPORT Page 133/148 TTeesstt ASrytsitcelme:| ETxEpLlGoNraMtCoOrHyL/2T8E-LDOaGyR GAaCRvYaLgAeTEStud/yRRIiSn/RRRoasts NPrOoOpKathno.no.:t 24525003130 Sponsor i3M Toxicology Services Date. + 21.ape.1999 Individsal Animal Data Records SFexi:m No: a86re Dosk Grove: pros c(rcoonstcionuperde) FroTIGS Mcroscopre PrwmIGS ver Kidnoy/1 uney/2 renal Gland/1 Mens) Gland/2 Spleen pe. Aatmal vo: 87 MACROSCOPIC FTIDINGS Mo findtngs noted MiSIdinnzfglolanemamlcaet/ioclreynntececairllolosbiufsloacrt(shi(ynspilemiragtlhr)t)ophy, diffuse (slight) Hepatocsllular vacuolation (sinisal) HTyuabluilnaer catarsotpsh)y, (cmoirntimiacla)l (minimal) Tubular atrophy, cortical (mintsal) Vacuolation, mitifocal in 2. fasiculata (minimal) Vacuolation, mitifocal in 2. fastculata (minimal) Hasopotasis, primarily erythropoiesis (slight) Lymphoid atxophy - involution (slight) NToesatbenso/r2m,aliNteiseesntefroiucndLyinm:phPNaondcer,easM,andTeisbtuelsa/rl,Lymph Node/1, andibulax Lyseh Noda/3. sdaaycsrifoifcetrgeraowtpment:: t29eminal sacrifice ddnaaectceeropoofsfyasntsdatrtoafotfturetssrte:eascnmpcal:nacn:n0e3/d0161/t/1e50r8/m5i6nal date of necropsy |: 04/11/50 No findings noted 000435 `PATHOLOGY REPORT Page 134/146 TTeesstt ASrytsitcelme:: TEExipcluoEraAtOoIrGyL/2T8E-LDNaEyR GAaCRvYaLgAeTEStud/yoRiiSn/eRToasts PNrOoTpOaKthmo.Ro.:t 24529003130 Sponsor i 3M Toxicology Services Date. + 21.2pr.1999 Individual Animal Data Records Asnxtal wo: a87te DosE Rove: PROS MicRoscopte FIDINGS Liver Kidnoy/1 spleen Fatma wo: 08 MACROSCOPIC FINDINGS KrcRoscorTe PIXDIIGS iver Pancreas Arenal Glana/1 Arenal Glana/2 MISiindnfzglolanemamlactecolerlnytnrecicelrloolbsuiflsoaolr(ahi(ynspileaisaglch)rto)phy, diffuse He(pnaotdoacreatlel)ular vacuolation (slight) HTyuabluilnaer caatsreo(psh)y, (cmoirntimiacla)l (atataal) Heopotests, prisartly erythropoiesis (minimal) NToesatbenso/rLm,aliTtesiteass/f2o,unAddcine:nalPanGclraensds/,1, KAiddnreeyn/aZl, Gland/ N2,odeT/h1y,milM,anMdeisbeunltaerriLcysLpyhmNpohdeN/ed2s., Mandibular Lymph Sdaaycsrifoficecrgeraomwepnt :: t29eminal sacrifice ndaetceroopfsysstattaotfutsre:atmpelnatn:ne0d6/t1e0r/m3i8nal ddaactee ooff neencdroofpsytr|eataan0t4:/110/39/811/98 No findings noted MISiindnfzglolanemamdcaotcloelrnytnrecicelrlolobsuiflsoaolr(mhi(ynspilemiragtlh)rto)phy, diffuse (odazate) poptosts/single cell necrosis, exocrine (minimal) Vacuolation, mitifocal in 2. fastculata (minimal) Vacuclation, mitifocal tn z. fasiculata (minimal) 000436 `sATHOLOGY REPORT age 138/148 TTeesstt ASrytsitcelme:: TEHxipolRoRraAtCoHryOL2/8T-EDaOyA GACaRvYaLgAeTE)Stud/yPRViSn/RRroasts |~ NPOrToOpXathno.mo.: 20525003130 Sponsor: 3M Toxicology Services Date. t+ 21.apr.1999 Zndividual Animal Data Records : AsDneoixs:mealGrovvore: r8pa8rtose M(xccornotsicnuoepdr)e pnwmIGs spieen -- Jatmal wor 89 MACRoscopIC FrDIIGS Mrcroscopze PrwmiGs Liver otal vor 90 cRoscoptc FrDINGS ver HHaozmoospiodteersitns',pipgrmiemnatril(yaienrizyatlh)ropotests (minimal) Lymphoid atrophy - involution (minimal) NToesatbenso/rlm,aliTtesiteess/f2o,unMdesien:nteKirdinceyL/y1m,phKNioddnse,y/2, Manaibulic Lymph Node/1, Mandibular Lysgh Node/2. dsaaycsrifoficetrgeraoutpment:: necropsy status: r29ecovery group planned recovery ddaattee ooff esntdartofotfretartemaetnmte:nt:030/61/11/09/838 ate of necropsy| 18/11/38 No findings noted MsIiindnfzglolanemamlcae/tlcolernytnrecciarllolosbiufsloaort(ahi(ynspileziragtlhr)to)phy, diffuse (slight) Hopatocallula vacuolation (minimal) dSaaycsrifoifcetrgeraomuepnt : necropsy status: r29ecovery group planned recovery ddaattee ooff esntdarotfoftretartemaetnnta:nc:030/61/11/05/898 cate of necropsy: 18/11/38 Accentuated lobular pattem 000437 `PATHOLOGY REPORT Page 136/146 TTeesstt ASrytsitcelme:: TErxipalmonraAtCoOrHOyL/2T6E-LDOaEyR GAaCvIaNgTeLStudy/eriins/eRraosts PNrOoTpOaXthmo.mo.: 24525903130 Sponsor + 3M Toxicology Services Date. + 21apei1s9s Individual Animal Data Records Asetx:ma vor w9a0le ose Grou: pros (accornotsicnuoerdt)e rims MrcRoscopze FmmnGs Iver Ratmal No: 1 HcRoscoRTc FIDINGS acRoscopre FIDDGS . Liver Atmel vor 33 MacRoscortc FnmINGS . Niosasbuneosrmaelxiatmiiensedvere found in any of the other : MISiindnfzglolanemamlcaetcloelrnytnrecicelrloolbsuiflsoalr(mhi(ynsptleziarglth)rt)ophy, diffuse He(pmaotdoecraetlel)ula(rcovrazceulsaltaetsiotno G(RsOlSigShtF)ind(icnogr)relates to `GRosS ining) ndseaacycrsroipofsfiycecsrgetarameotnuut ps::: r25ecovery grow planned recovery adattee ooff asntdatofotfretartemaetnmte:nt:03/0161//1908/98 date of necropsy + 18/11/98 Wo findings noted MIindfzloanmamla/tcoernycrcielllabuolcatr (sodezate) h(yspleirgthrt)ophy, diffuse Hepatocellular vacuslation (slight) dsaaycsrifoifcetrgeratomuenpt:: r29ecovery group 2 dnaetceroopfsystsatrtaotfutsre:atmpelnatn:ne0d6/z1e0c/o3v8ery 2 Gdaattee ooff neencdzoofpsytrescm+en0t3:/120/35/811/98 000438 PATHOLOGY REPORT rage 137/146 TTeesstt ASrytsitcelme:: ETExLpOlGoAraAtCOoHrOyL/2T0E-LODWaEyR GACaRvYaLgAeTEStud/yPRiIGn/eRroasts PNrOoTpOaKthmo.no. 24525003130 Sponsor + 3M Toxicology Services Date. t+ 21.2pr.1999 Individual Animal Data Records : osatxa: l wer N9a3te Dose Grove: pros. M(ccRonotSiCnOuPeId)C PIIDTIGS acRoscorTc FINDINGS iver : Fatma vo: 94 McRoscorIc FINDINGS Mrcoscoprc FrwIIGS Liver Antal No: 95 MacRoscorte FmIIGS Yo findings noted MSIiindnfZglolanemamlactecloelrnytnrecicolrloolbsuiflsoacrl(ahi(ynmptiemnraitlm)arlo)phy, diffuse (minima) dSaaycsriofficetrgearcmoenutp:: 2r9ecovery grow 2 ndaetceeoopfsystsatrtaotfutsre:atpmelnatm:ed06r/e10c/o9v8ery 2 ddaattee ooff neencdroofpsytreatm+en0t2:/120/39/811/38 Yo findings noted MIindfzloanmamlatcoernytrciellolbufloacrt h(yspiegrhttr)ophy, diffuse He(pmaotdoecreatlel)ular vacuolation (minimal) dSaaycsrifoifcetrgearmoenutp:: 2r9ecovery group 2 dnaetceroOpfsystsatrtaotfutsre:atmpelnatn:ned06r/e10c/o3v8ery 2 ddaattea ooff ennedcroofpstyreatmen0t2:/120/39/011/38 No findings noted 000439 `PATHOLOGY REPORT TTeesstt ASrytsitcelme:: ETxepilonraAtCoOrHyOL/2T0E-LDOaEyR GAaRvaYgeAStud(yPRiWnS/PRRaSts Sponsor + 3M Toxicology Services age 130/146 PNrOoTpOaXthmo.mo.: 24929003130 Date : 21.apr.1s99 Individual Animal Data Records . sAext:ma No: r95ae DosE Grou: pros McRoscorrc FmmINGS Tver rEaxt:mal No: F17e7nnte McRoscoprc FrwmIGS acRoscoPte FIDDGS iver Kidney/2 Mrenal Glana/1 spleen hms MSIiindnfzglolanemamlac/teclolreynntecrceirllolasbiufsloets(shi(ynspileniragtlh)tr)ophy, diffuse (sight) aSaycsrifoifcatrgeratomuenpt:: Dacropsy status: t20aminal sacrifice planned terminal ddaattae ooff setnadrotfoftretarteaamtnmte:nt:04/0161//1908/90 date of necropsy. 05/11/98 Yo findings noted SIinnfgllaemmcaetlolryneccerlolsifsoci(mi(nsilmiaglh)t) Midzonal[centrilobular hypertrophy, diffuse (slight) Tubular atrophy, cortical (atninal) Extracapsulaz nodule present HHeeszoospiodteersitns',ppirgismeantril(ysleirghytt)hropoiesis (minimal) . Lymphold atzophy - involution (ninisal) NNooovdaaerb,yn/o1Mr,amnadloiviabtzuiyle/sa2z,foLAuydnmrdpehnianN:lodeGP/la1an,ncdr/eH2aa,sn,dMiebKisudelnnaetrye/rLliy,cmpLhymph Node/2. 000440 PATHOLOGY REPORT Page 139/145 TTeesstt ASrytsitcelme:: ETxepulonraAtCoOrHyOL/2T8E-LDOaGyR AGCaRvLaAgTeE/Study/eniins/eRracsts PNrOoTpOaKthmo.no.: 24529003130 Spemsor 1 3M Toxicology Services Date. 21.apr.1995 Individual Animal Data Records rsext:m wo: P1e7asle Dose Grove: pros McRoscoPrC FnwINGS acaoscortc FvDDIGs iver Kidnoy/2 Adrenal Gland/1 Spleen ratmal wo: 178 MACROSCOPIC FIIDOINGS Saaycsrifoficetrgeraoutpment:: Recropsy status: pt28elramninneadltesramcirniaflice GGaatcee ooff satnadrtofoftretartemaetnmte:nt:04/0181//31809 ate of necxopsy + 05/11/90 No indtngs noted HIindfzloanmamla/tcoernytrcielllabfuloacr h(yapienrttoralo)phy, diffuse (slight) I`Tnutbeurlsatritaitarloph{yn,flcaomrattiicoanl, (lmyimnpihmaolc)ytic (minteal) Small glands, nomal morphology. Hamosiderin pigment. (minimal) NOovaazbyn/oLr,maloviatciye/s2,foMunednian): PGlaanncdr/e2a,s,TKhiymdisse,y/l, MMaensdeinbtuelraicc LLyymmpphh HNooddee/,2.Mandibular' Lymph Node/1, dSaaycsriofficetrgearemoenutp:: t20erminal sacrifice dnaetceroopfsystsatrtaotfutsre:atmpelnatn:ne0d8/c1a0r/a5i8nal ddaattee ooff neencdroopfsyt|reatmen0t5:/110/43/811/98 No findings noted 000441 `PATHOLOGY REPORT Page 140/146 TTeesstt ASrytsitcelme:: Sponsor: ETxEplLoraAtCoOrLy/T2E8L-DOaGyR AGCaRvYaLgATeE,Stud/yeFiiSn/iRrcaets 3M Toxicology Services PNrOoTpOaXthno.no.:+ Date. 24529003130 21apr.1993 _--_--m Individual Animal Data Records . seAxt:ma wer DOSE Group: Fp1re7om9sa.le rrcRoscopte FnmnGS iver Spleen rtm wer 100 McRoscopze FmmIvGs xcroscoprc FrwmiGs Liver i Kidnoy/1 Spleen MSIiindnfzglolanemamlcae/tlcolernyntercciarllolosoiufsloacrk(shi(ysnplteiarglth)rto)phy, diffuse (eodozate) Hezostderin pigment (noderate) NAoKdiradenbnenayol/r2m,aGlliaOntvdia/zezys,/1f,TohuyOnmvduasri,yn/:2M,ePasAnedcncrteeeanrsai,lc GKliadnnde/yl/,l, Lysgh Ned, Mandibular Lymph Node/1, Mandibular Lymph Node/2. sdaaycsrifoifctergeraotpment:: necropsy status: t20aminal sacrifice planned terminal ddaattee date ooff of nesetncadrrootpfsoyftretartema+etnm0te5:n/t1:10/49/08181//1900/98 Yo findings noted MIin(dfmzlionanimazmlaa/lt)coarnytrciellolbuflocair h(yspleirgthrt)ophy, diffuse Interstitial {nflumation, lymphocytic (minimal) HHaemmoopsoitdeasrtisn,pipgrmiemnatril(y31e4GrAy6t)hropodesis (minimal) N`ooTvhaayzbmynu/so1,r,mMaelOsiveatrniyte/es2r,ifcoAudLnrydeznpianhl:NoPGdlasan,ncdr/eM1aa,sn,dMiKbriuedlnnaaerly/TzGy,inapnhd/2, Wode/1, Nandibula Lymph Node/2. 000442 PATHOLOGY Repo Page 142/145 TTeesstt ASrytsitcelme:: Sponsor i TEexpolmoaraAtLoCrOyL/2T0E-LDOaEyR GAaCKvIaAgTeE/Study/eiTInS/RP0asts 3M Toxicology Services PNrOoTpOaXthno.mo.: Date : 25452091303 21.apr.1999 _---- Individual Animal Data Records Jsnetx:mal Ne: r1e0s2ale oosE Grove: pros. MrcRoscopC FumiGS Liver Kidney/1 Spleen Ma1ndibular Zymgh Node/ rated vor 163 croscopic rmmiGs xcRoscopc FINDINGS Liver Kidney/1 Spleen Ma7ndibular Lymph Node/ MIindfzloanmamla/tcoornytrciellolbufloacrt (modecate) h(ympienrttsraol)phy, diffuse Tubular atzophy, cortical (mintaal) HHeemmoopsoildeesrtisn,ppirginmeantril(ys3e4grhytc)hropodesis (nintmal) Plasmacytests (slight) NOTohvyasmzbuyns/o,1r,mMaelosiveatrniyte/es2r,ifcoAmdLedyeznpianh:lNoPGdlaean,ncdr/Melaa,sn,dAidbKruieldnnaearyl/T2yG,oiagnhd/z, Node/2. ndseaacycrsroifpoisfcyetrsetgaarttmuoesnutp::i 2tp5leamninneadltsearcmeiinaflice ddaattee date ooff of ansentcdarzotopfsoyftrteraetam|:temn0et8:n/t1:10/590/8181//1908/98 Yo indings noted MsIiindnfzglelanemamlcaet[loclernynterccierllloosbuiflsoacrt(shi(ynaipinenartlem)zaol)phy, diffuse (moderate) Interstitial inflamation, lymphocytic (minimal) Henstdarin pigment (slight) Plasmacytosis (slight) 000443 `PATHOLOGY RepoRT Page 143/146 TTeesstt ASrytsitcelme::TEExLpOlGoRrAaLtCoHrOyL/2T8E-IDOaGyR GAaCRvYaLgAeTEStud/yPFiISn/IRRaGSts PNrOoTpOaXthno.ho..: Sponsor i 3M Toxlcology Services Date. t+ 24923903130 21.2pr.1998 -_-- Todividual Animal Data Records asetx:m wo: T1e0a3le Dost Grove: pros. M(rccoRnotsicnioepdr)c FrmmiGs Atma vor 184 cRoscorre FnmmNGs MrcRoscoprc FnwmiGS ver Kidnoy/1 Spleen N NhOoyvamazbiyns/o,Lr,mMaelosvieatzniyte/se2r,fiocAuLnrydemnpianhl:NoPGdlaean,ncdr/eMlsa,sn,dAidbKruiedlnnaearyl/L2yG,hmapnhd/z, Node/2. dsasycsrifoifcetrgosrmeantp: necropsy status: t29eminal sacrifice planned terminal ddaattee date ooff of nseetncadrrotopfsoytfretarteaa+stam0te6:n/t1:10/590/881/11/09/898 No findings noted MIindfzloansaslatcoernytrciellolbufloaorl h(yipnetratarlop)hy, diffuse (siight) Tubular atrophy, cortical (aintnal) HHeommoopsoildeasrtisn,plporsiemnatril(ys1ieGrhytt)hropolests (ainimal) NoOThvyasmzbiyms/o,1r,mMaelOvisatezinyet/se2r,ifcoAudnLrdyeznpianh:lNGoPdlaean,ncdr/eM1aa,sn,daidKbriuedlnnaearyl/L2Gy,imapnhd/z, Node/1, Mandibular Lymph Node/2. 000444 `PATHOLOGY REPORT Page 144/146 TTeesatt ASrytsitcelme:: Sponsor: TEHxipoleonraAtLoCrHyOL/2T8E-LDOaRyR GAaYvIaNgTeE/Study/PiRNnS/RPaOSts 3M Toxicology Services PNrOoTpOaKthno.no.: Date. + 24929903130 20apr.1s9s -_-- Individual Animal Data Records - Fsaxt:ma wo: 1Z8e5aste DosE Group: pros. McRosCoPIC PIDINGS { MrcRoscopre FrwmiGs Liver Patmal No: 186 mcroscopre FrwmiGs McRoscopre rmwmics Liver Atma wo: 187 McRoscoprc FnmINGS ndseaacycrsroipfosfiycstsrgetarattomuewnst::: pr2le9ecsomveedryregcroouvpery ddaattee date ooff of nseetncadzrotopfsoyftretartems:ecna2ta0:n/t1:10/59/081011/09/690 No findings noted Inflamatory coll foc (aintsal) ndseaacycrsroipfosifycetrsgetscrametanueps:: 2r9ecovery group planned facovery ddaattee date ooff of sentenacdcztoopfsoyftretartema+etnm2te0:n/t1:10/53/08181//1300/58 Yo findings noted MiIdnzfolanmamlatfocrayntcreilllobufloalr (minimal) h(ympienritmraol)phy, diffuse dnsaeayccsrroifpoisfcyetsrgetxrtamotenuutps::: 2r9ecovery group planned recovery ddaattee date ooff of setnadrotfotfretartemaetnmtesnt:05/0181//108/858 necropsy + 20/11/88 000445 `PATHOLOGYFERoRT Page 145/146 TTeesstt ASrytsitcelme:: Sponsor: TECxLpOlEoRraAtLCoOrHyOL2/0T-ELDMaEyR GACaRvYaLgNeTE/Stud/yEMiSn/ERRaSts 3M Toxicology Services | NPOrToOpXathno.ho. Date. : 24929002130 212pr.1993 ---------------------------------------------------------- Tadividual Animal Data Records . rsaxt:mal vo: T18e7asle DOSE Grove: pros. c(Rcoonstcinouperd)c romiGs acRoscoprc rwmGs ver Animal No: 169 acaoscopre FomGs MacRoscopC FINDINGS iver Antal Mo: 150 McRoscoPIC FrOmIGS MrcRoscoptc Fnwmics Liver No findings noted sIinnfgllaemmcaetlolryneccerlolsifsoct(mi(nsilmiaglh)t) dsasyesrifoficetrgeraotwmpent 1 neczopay status: 2r9ecovery group 2 planned racovery 2 ddaattee date ooff of nesetncadrrtoopfosftyretartema+stnh0ta4:n/t1:26/59/08181//1909/58 No findings noted SIinnfglluemacteolrlyneccerlolsifsoct(mi(nsilmiaglh)t) nsdeaacycrsroipfosifycetrsgetartaomwetnut s:1: p2rl9eacnonveedryrgercoouvper2y 2 daattaa date ooff of nesnetdcarrootfpsotyfretartema|:etnh0te4:n/t1:20/55/00181//1500/38 No findings noted SIinnfgllaemmacetlolryneccerlolsifsocl(si(nmiiznailm)al) 000446 `PATHOLOGY REPORT age 146/146 TTeeaatt ASrytsitcelme:: Sponsor + T3EexMLpoTlHeEoRxriAacLtoColOroyLg/y2T8ES-LeDOraGvyRicGAeCaRsvYaLgATeE!Stud/yeMiisn/bRraosts PNrOoTpOaXthno.no.. Date 24323003130 21.2pe.1559 Individual Animal Data Records sfexa:ts wo: DOSE Group: F1e9m1ale pros McRoscopre FnmmvGs xcroscopre rnmmics ver Ddsaaeyccsrriofpoiafcyetrsgetrsotamueptnut s::i p2r9elcuomveedryregcroovwers2 2 ddaattee date ooofff nesentcdazrooepfsotyfretxrcemx+ stnh0ta4:n/t1s20/55/08181//1908/95 No findings noted In(fdmlziaonmnimmaalal/t)coernytcrailabufloaort h(yipnetrmtarto)phy, diffuse 000447