Document G6GzydKY4xMOqQm98a6EDjpeY

ILefttcffl! fc#Mss!tapiss Jlmmmmkmtfmm ANDREW FLETCHER,PRESIDENT K.C. BROWNELL,VICE PRESIDENT U. A. MARTINO, VICE PRESIDENT M. M. ZO LLE R , VICE PRESIDENT ROBERT LtNDLEY ZIEGFELO, SECRETARV-TREASURER 60 EAST 42n d STREET NEW YORK 17,N.Y. MANFRED BOWDITCH DIRECTOR OF HEALTH AND SAFETY September 13, 1937 Robert A. Kehoe, Il.D., Director Kettering Laboratory University of Cincinnati Eden Avenue Cincinnati 19, Ohio Dear Bob: As you may well know, there have been indications of late that the ghost of the alleged lead hazard from automotive exhaust gases had not been as deeply and finally laid as we had hoped. Mow, as you will note from my enclosure, comes a chemist lady from the University of Chicago vdth a statement which, while less eortrene than some, is certainly disquieting. You will recall, I think, that when that crazy Los Angeles crew came out with their wild contentions, I secured figures on lead in street air from official agencies in a number of our larger cities and found none re motely indicative ox a hazardous level. Before going after Miss Tufts with a hot poker, I would welcome word from you as to whether you know of any recent evidence from any sources which would be at all supportive of her contention h' Sinceaely, MB ;GF Enclosure cc; Mr. Costello P. S. Since dictating the above, I have received a notice of the Semi-Annual Technical Conference of the Air Pollution Control Association to be held at San Francisco, November 18th and 19th, and note that Dr. Herbert C. McKee of the Southwest Research Institute is to give a paper on the afternoon of the second day with the title "Particulates in Automobile Sh-iausts.1* I would think that we should find a way to secure a copy of this caper . ' f ! / \ \ \ NEW YORK WORLD-TELEGR&Bfl AND SUN. WEDNESDAY, SEPTEMBER 11.1957 -Science and Medicine- 2 New Chemical Agents Attack Only Cancer Cells INew hope in the fight curring compounds called sity of Chicago chemist to the against cancer has been of midines only in the substitui n American Chemical Society fered by two research groups of a fluorine atom a hydrogen atom. in placet meeting here today. reporting at the American He said earlier resea With the small concentrations Chemical Society's 132nd an- showed that uracil, a pyr of lead particles in the atmos -ual meeting. dine, was taken into the phere, no health hazard exists Chemists from the Univer sity of Wisconsin and from Hoffmann-La Roche, Inc., Nut- ley, N. J., announced that two new agents have been devel oped and used successfully against cancer in mice eleic acid of tumor tissues a higher rate than into nori tissues. This led to a ``chem hunch" that the replacing c hydrogen atom with a fluoi atom would combat the car cells, he said, and experime rats. it for most of the population, said Barbara J. Tufts, Depart ment of Meteorology chemical le er ts h. analyst, "except possibly to those whose occupations re quire a constant exposure to highway atmospheres." Miss Tufts reported she drew Dr. Charles Heidelberger the University of Wisco Gasoline Additive air samples through fine mem brane filters that captured all told the society's division biological chemistry yesteri Dangers Cited lead particles, then chemically analyzed the filters for lead that the agents, called a; By DAVID PURSGLOVE, content. She found the greatest metabolites, were accepted Science Service Staff Writer. number of particles to be of a cancer cells. They prom; Anti-knock gasoline additives size that could most easily upset the metabolic procesi containing lead may threaten reach the lung, one to three of these cells, he said, altho the health of persons whose microns. A micron is about; they had little.effect on nor) Occupations keep them in heavy four one-hundred-thousands of cells. automobile traffic, although an inch. Laboratory tests, he s there is no health hazard to the demonstrated "a high order majority of the population. tumor-inhibitory activ against transplanted turn A study of tiny lead particles formed from the combustion of plete PHOTOGRAPHY COVKRAGK Miy daily in America! Today and in rats and mice." Further experiments needed to determine the age gasoline containing tetraethyl lead was reported by a Univer p day there's a special feature for ; fcra fans only in the World-Tele- and Sun. effect on humans, he said, predicted, however, that c rent studies would provide val uable information on tumor metabolism and might lead to development of even more po tent anticancer compounds. Dr. Robert Duschinsky, a IIoffman-La Roche scientist, identified the two new agents as 5-fluorouraciI riboside and 5-fluorouraciI deoxyriboside. They differ from naturally oc- Ht 0014342 N18574.01