Document G6ErKYzJNaXaok9nXb0wLpwym

y To Fr o m Su b j e c t ETHYL CORPORATION i n t e r -o f f i c e CONFI DENTI AL D r . R . A. . K,, e hi o e R . K . S,, c a,l e s Ad d r e ss Ad d r e ss Da t e Cin cin n ati D etroit O ctob er 7, 1958 D ear Bob: Attach ed a r e som e b r ie f m in u tes on our d iscu ssio n s in vour office on M on day. I h ope I h ave quoted you c o r r e c t ly an d accu r at e ly r efle cte d your opin ion s. If I h ave m isqu oted you in an y w ay, le t m e know an d I w ill se e th at the r e c o r d is straigh ten ed out. Th an ks ever so m uch for all the tim e and effort you put in to our m eetin g. I'm an xiou s to keep th is p r o gr am m ovin g r igh t alon g, so w ill be in tou ch w ith you again m the n ear fu tu re. Best r e gar d s, R KS/d l Att. R. K. Scale s K& 0020525 N21921 CO NFERENCE REPO RT CONFI DENTI AL P eop le in Con fer en ce: D r . R . A . Keh oe M r . H . H. W all M r. W. G. Lovell R. K. Scales D ate of C o n fe r e n ce : O ctober 6, 1958 P lace: D r . Keh oe's office in Cin cin n ati O ctober 7, 1958 M r . Sc a le s r e p o r t e d on a teleph on e c o n v e r sa t io n h e h ad w ith M r. M acG r ego r of Stan d ar d O il of C alifo r n ia on O ctober 3. In h is t e le phone call M r. M acG regor stated th at: 1. Stan d ard O il of C a lifo r n ia 's fu n d am en tal in t e r e st con tin ues to be in tetram eth y l lead . 2 . DuPon t h ad m ade a b etter offer than Eth yl both a s to tim e of d eliv er y an d p r ice fo r tetr am eth y l lead . Stan d ar d O il of C alifo r n ia, t h e r e fo r e , h ad d ecid ed to w ork w ith D u P on t e xclu siv e ly on tetram eth y l le ad . Th ey look ed upon the m ixed le ad alk y ls w h ich we h ad d isc u sse d w ith th em on t h e ir v isit to D e t r o it on Se p t e m b e r 9 a s E t h y l's exclu siv e d evelopm en t. Th ey did n ot plan to d isc u ss the m ixe d le a d a lk y ls w ith D u P on t. If Et h y l cou ld sh ow b e t t e r e ffe c t iv e n e ss at the sam e co st or th e sam e e ffe ct iv e n e ss at low er co st w ith th e m ixed lead alk y ls a s co n t r ast e d w ith tetr am eth y l lead , Stan d ar d of C alifo r n ia w ould be in t e r e st e d . M r . Sc a le s a lso r e p o r t e d th at oth er co m p an ies, p a r t ic u la r ly E sso , Socon y M ob il an d C a lt e x , h ad lik e w ise sh ow n an in t e r e st in m o r e v o latile le ad com pou n d s. Eth yl h as in the p a st d is co u r aged th is in t e r e st on the p ar t of c u st o m e r s, bu t in view of th ese d evelop m en ts w ith Stan d ar d of C alifo r n ia we h ave an ob ligation to le t th em know of our p r e se n t co n sid e r atio n s of the p o ssib ilit ie s of m an u fac turin g the m ore volatile lead alk yls com m ercially . D r. Keh oe stated th at: 1. DuP on t h ad n ot a s yet con tacted h im fo r an opin ion on tetram eth y l le ad . He h ad exp ected th at th ey w ould do so b efo r e actu ally plan n in g on offerin g it a s a co m m e r cial product. 2- - 2. In h is opin ion DuPon t w ould d isc u ss an y p lan s th ey m igh t h ave fo r c o m m e r c ia l p r od u ction of t e t r am e t h y l le ad w ith the P u blic H ealth Ser v ice b efo r e th ey m ade it av ailab le c o m m e r cially . T h is w ould be in acco r d an ce w ith the ge n t lem an 's agr e e m e n t w h ich both DuPon t an d Eth yl h ave w ith the Su rgeon G e n e r a l's o ffice to d isc u ss w ith th em an y con tem p lated d evelop m en ts w h ich m igh t be c o m m e r cialized . 3. In h is opin ion th e Su r geon G e n e r a l's o ffice w ould look w ith d istin ct d isfav o r on the su b stitu tion of te tr am e th y l le ad for tetraeth y l le ad . A lso , the m ixed le ad alk y ls (M A-500 h avin g a v ap o r p r e ssu r e 10% th at of t e t r a m e t h y l le a d a t low t e m p e r a tu r es) m igh t be accep tab le if we h ad m or e back grou n d on the toxicity of th ese m a t e r ia ls. M r. W all r ep o r ted th at: 1. M an u fact u r in g cou ld m ak e M A -500 m ix (50% Eth y l r a d ic a ls) in existin g equ ipm en t at eith er Baton Rouge or P ittsb u r gh . M od ification s of equ ipm en t w ould, of co u r se , be in volved. 2. P itt sb u r gh w ould be p r e fe r ab le b e c au se of the la r g e r au t o clav e s at th is location . In th e case of p o ssib le u se by Stan d ar d of C alifo r n ia, th e ge o gr ap h ical lo cation h as an added advan tage. 3. O p tim istically we could be in produ ction of M A-500 at P ittsb u r gh in ap p r oxim ately a y e ar ; th is e stim ate d tim in g w as b ase d on six m on th s stu dy an d p ilot plan t w ork an d an ad d ition al six m on th s for m ak e - r e ad y in the p lan t. 4. T etr am et h y l le ad w ould take m uch lo n ge r - - c o n sid e r a b ly over two y e ar s at b e st - - sin c e existin g fa c ilit ie s could not be u sed . A fter addition al d iscu ssio n , two gen er al assu m p tio n s w ere m ade and a p rogram w as agreed upon. The gen eral assu m p tion s w ere: 1. Th at D u P on t m igh t give up on tetram eth ,yl le ad a s a c o m m e r c ia l p r od u ct a ft e r d isc u ssin g the m at t e r w ith th e Su r geon G e n e r al's office. 2. Th at it m igh t be p o ssib le to con vin ce Stan d ard of C alifo r n ia th at it w ould be h azar d o u s fr o m a t o xicit y stan dpoin t to u se tetr am eth y l le ad co m m e r cially an d th at in view of th is th ey m igh t be fav o r ab ly d isp osed tow ard M A-500 as a co m p r o m ise. 3- - The p rogram that w as agreed upon is as follow s: 1. D r . Keh oe w ill c a ll h is grou p at the Ketter in g Lab o r at o r y togeth er to outlin e a p r o gr am for fu rth er w ork on toxicity of the m o r e v olatile le ad alk y ls. T h is p r o gr am w ould be aim ed at: a. Rech eck in g sk in ab so r p tio n s of t etr am eth y l le ad an d the m ixed lead alk y ls. b . D evisin g e xp e r im e n t s fo r sk in ab so r p tio n t e st s when th ese m a t e r ials ar e d isso lv e d in gaso lin e . c . Set up a stu dy of th e d istr ib u tio n of the e ffe ct s of th ese m at e r ials on exp erim en tal an im als. d. D eter m in e w h eth er th ere a r e an y ch an ges in the e ffe ct s on m etab o lism in the su bstitu tion of the lead alk y ls for tetram eth yl lead. D r. Keh oe w ill set up the above p r o gr am and its accom pan yin g budget and sen d th is on to D r . Kir b y . He e st im a t e s th at a total of two y e a r s' w ork w ould be r e q u ir e d but th at the d e c isiv e an sw er w h ich w ould be n eed ed by th e P u b lic H ealth Se r v ic e cou ld be obtain ed in fr o m six m on th s to a y e a r 's tim e. Th is w ould fit in to ou r con tem plated on e-year p rogram for com m ercialization . 2. Th e D etroit Lab o r at o r ie s w ill set up a p r o gr am to gath er togeth er all the existin g data and se t up fu rth er exp erim en ts to determ in e w h eth er M A-500 or an y oth er of the m ixtu res w ould be a sa t isfa c t o r y su b stitu te for t etr am eth y l le ad in p r e se n t- d ay fu els an d en gin es. 3. M r . W all w ill h ave Baton Rou ge go r igh t ah ead w ith th eir p ap er stu d ies aim ed at m an u factu rin g M A-500 m ix at P itt sb u r gh in a y e a r 's tim e. A s soon a s p o ssib le Baton Rou ge w ill r e fin e th e ir e st im a t e s on the co st of M A-500 so th at th is can b e r e p o r t e d to p r o sp e ctiv e cu st o m e r s aft e r th e p r o p er cle ar an ce w ith in the C o r p o r at io n . Baton Rouge w ill also im m ed iately set up stu d ies of the con cen tr ation s of the m or e v olatile lead alk y ls in the v ap o r s of gaso lin e un der v ar io u s con d ition s. A co n sid er ab le am oun t of d at a on th is su b je c t a lr e a d y e x ist s in the D e t r o it file s. T h is w ill be sen t to M r . W all. In addition , M r . T . W. W arren of the D etr oit La b o r a t o r ie s w ill recom m en d to M r. W all the gasolin e or gaso lin es to be u sed for th ese t e st s.