Document G692x9dYVEGO5XakpxzgOE1pq

RULES AND REGULATIONS 2-,20' To bo a valid aw.:v, (lie percent column recovery should ... 100*2 percent. id! Identity. Proceed as directed in 5 141.521 of this elm;iter, using a 0.5 percent potassium bromide disc prepared as described :n paragraph (b> (1) of that requisite to providing for its certification have been complied with and since not delaying in so providing is in the public interest, notice and public procedure anl delayed effective date are not prerequi sites to this promulgation. Signed at Washington, D.C., this 2d day of December 1971. G. C. Guenther, Assistant Secretary ol Labor. I FR Doc.71-17835 Filed 12-6-71:6:47 am ] section. (7) Crysic.il::::.-;. Proceed as directed in 5 141.504(a) of -his chapter. 5 130g.ll . yoli<* liydrocliloride Effective date. This order shall be ef fective upon publication in the Federal Register (12-7-71). (See. 607, 69 Stat. 463, as amended: 21 U.S.C. Chapter XVII--Occupational Safety and Health Administration, De partment of Labor ulo. 367) PART 1910--OCCUPATIONAL SAFETY (a) -lee.uire::... ..s for certification-- (1) StcnCzr-j of identity, strength, quality, and purity. Minocycline hydro chloride capsules -..re composed of mino Dated: November 21, 1971. H. E. Simmons, Director, Bureau ol Drugs. AND HEALTH STANDARDS Emergency Standard for Exposure to Asbestos Dust cycline liydrocliloride and one or more [FR Doc.71-17773 Filed 12-6-71:8:46 am] suitable and harmless lubricants and dil uents enclosed in a gelatin capsule. Each capsule contains minocycline hydro chloride equivalent to 100 milligrams of Title 29--LABOR minocycline. Its potency is satisfactory if It is not less th..n 90 percent and not Chapter XIII--Bureau of Labor more than 115 percent of the number of Standards, Department of Labor milligrams of minocycline that it is rep resented to contain. Its moisture content PART 1518--SAFETY AND HEALTH is not more than 12 percent. The mino- . REGULATIONS FOR CONSTRUCTION cycline hydrochloride used conforms to the standards prescribed by loOg.l(a) (1). Standard for Exposure to Asbestos Dust (2) Labeling. It shall be labeled in ac Pursuant to section 4(b) (2) of the cordance with the requirements of 148.3 Williams-Stciger Occupational Safety Pursuant to section 6(c) ol the Wii- liams-Steiger Occupational Safety ar.d Health Act of 1970 (84 Stat. 1596, 29 U.S.C. 655), Part 1910 of Title 79, Code of Federal Regulations (36 F.P.. 10463, May 29, 1971) is hereby amended Li the manner indicated below in order to pro vide an emergency standard dc-al.n ; with the exposure of employees to asbestos dust. In light of increasing information or. the results of exposure of employees to airborne asbestos dust, induce/, g recent studies by the National Ir.otituto for Oc cupational Safety and He:.lth ar.c ct.-.ers. and recommendations by the T.-.-nca:. of tills chapter. (3) Requests lor certification; sam ples. In addition to complying with the requirements of 5 14C.2 of this chapter, each such request shall contain; (1) Results of tests and assays on; <c) The minocycline hydrochloride used in making the batch for potency, safety, moisture, pH. minocycline con tent, Identity, and crystallinity. Cb> The batch for potency and and Health Act of 1970 (84 Stat. 1592, 29 U.S.C. 653), 5 1518.55 of Title 29. Code of Federal Regulations, is hereby amended in the manner indicated be low in order to prescribe a new stand ard limiting the exposure of workers to asbestos dust. The new standard limit ing the exposure of employees to asbes tos dust is that adopted under section 6(c) of the Williams-Stelger Occupa tional Safety and Health Act of 1970 Conference of Governmental I; .u.-tri.i. Hygienists (ACGIH), it L, hero'. dcT..-, - mined that (1) exposure unde.-1 t prev ent standard for asbestos dust Table G-3, 5 1910.93, of 12 fibers pc-r . .fiilitcr greater than 5 microns in lea. i or 2 million particles per cubic foe: si a. . which is derived from an estabk.) . eral standard promulgated tav r Walsh-Healey Public Contract; .o; May 20, 1969, constitutes a gr.v. c anger moisture. and published in the Federal Register to employees exposed to th^.- -:o-- (ii) Samples required: on this date. The standard is hereby de time-weighted average cancer.. va-v.. Co) The minocycline hydrochloride termined to be more effective than that and that (2) an emergency sz. ,rc used in making the batch; 10 packages, presently provided under 11518.55 to necessary to protect employees ti-.i.-, each containing approximately 300 the extent that it prescribes minimum excessive exposure. The Nation^. .'r.s,,- milligrams. levels of exposure to asbestos dust. tute for Occupational Safety and .-.c-alti. Cb) The batch: A minimum of 30 capsules. Cb) Tests and methods' of assay--(1) Potency. Proceed as directed in 5 141.111 of this chapter, preparing the sample for assay as follows: Place a representa tive number of capsules into a high-speed glass blender jar with sufficient 0.1If hydrochloric acid to give a stock solution of convenient concentration containing not less than 150 mlcrcgrams of mino cycline per milliliter (estimated). Blend for 3 to 5 minutes. Remove an aliquot ar.d further dilute with 0.1M potassium phosphate buffer, pH 4.5 (solution 4), to the reference concentration of 0.100 microgram, of minocycline per milliliter (estimated). (2) Moisture. Proceed as directed in 5 141.502 of this chapter. Therefore, by operation .of section 4(b) (2) of the Act the new standard issued under section 6(c) supersedes the con struction safety standard relating to ex posure to asbestos dust. Section 1518.55 is hereby amended by adding a new paragraph (c) thereto. As amended $ 1518.55 reads as follows: 1518.55 Gases, vapors, fumes, dusts, and mists. (c) Paragraphs (a) and (b) of this sec tion do not apply to the exposure of em ployees to airborne asbestos dust. When ever any employee Is exposed to airborne asbestos dust, the requirements" of S 1910.93a of this title shall apply. Effective date. This amendment shall become effective upon publication In the concurs that the proposed change :n the asbestos dust standard recommenced by the American Conference of Got cmn.(ra tal Industrial Hygienists should be t.-.c substantial base for the cme gor.cy standard. Action concerning the standarc. will .e commenced under section 6(b) in the immediate future. Any notice of pro posed rulemaking under section 6(b) will give notice of the emergency standard as a proposed rule and also of any ap propriate subsidiary proposals which may be required under subparagraphs (5) and (7) of section 6(b) relating to the ex posure of employees to toxic substances. Fart 1910 Is amended as follows: 1. Table 0-3 following 5 1910.93 (36 PR. 15104, Aug.' 13, 1971) is hereby amended by deleting the following: Asbestos--12 fibers per milliliter greater than Bata supplied by the manufacturer' Federal Register (12-7-71). q, 6 micron* in length or2 Mppcl. concerning the subject antibiotic have (See. 4(b)(2), 84 Stat. 1692. 29 U-8.0. 663; TremoUte__ .......... 6 Uppcf. 20mg./M* been evaluated. Since the conditions pre Secretary's Order No. 12-71,86 FJL 8764) ~%SIOl . 235 13 PLAINTIFF'S EXHIBIT FEDERAL REGISTER, VOL. 36, NO. 234--TUESDAY, DECEMBER 7, 1971 ASA-611 ASARCO ELP 0000336