Document G67DX1Kn45nyLBOrOyKa58Nex

FOR DU FONT PSR nwrv AR226-2772 Copies to H askell L a b o r a t o r y M e d i c i n e Elkton Road, P. 0 . Box 50, " Newark, Delaware 19711 HASKELL LABORATORY REPORT NO. 828-81 r i l Tested --------- 5-- ;------------- " ammonium saac ll dt *' P i n t .d e c .f l .o r o - , lJT T r M r ^ 2) 14,249 S t u d y I n i t i a ted/rfin.r i^,rT.rf 10/28/81 - 11/24/81 ~rtl E F F E C T S OF' CR&D Department ' H askell Laboratory Pr_ d o s i "*R or p o s t-d o s in g w it hi 1000 mg/kg changes the t#xic e f f e c t s o f at A l l r a t s dosed w ith t h e M M ^ i e i t h e r h Jm,oniura p e r f l u o r o o c t a n o a t ^ S S S . p e r flu o r o o c ta n o a te had r e d u ^ R o r t a l i t i e ^ 6 r aI t e r the aran,onl` i ammonium p e r flu o r o o c ta n o a te a lo n e . compared to the r a ts dosed w ith Smed" " ' as - m ale r a t s , 6 p er group a t . 050^ 0 0 ^ 0 1 ^ O o 'm r/ k r p" r a ts were in tu b a te d ^ e ith e r b efore or a ft e r th* g/ w t h 1000 mg/kg . TM M5 rl:C D " "g adult g r UpS f th e se P e rflu o ro o c ta n o a te The r . t s were d iv id e d lu t e the fo llo w in g g r ,, ,, p s ; Group I : dosed with C-8 o n ly . " I I =g d j j ^ j , C-8 and Im m ed iately fo llo w e d by a doae o f Group I I I : dosed w i t h l S f l M i B H M M i l , . _ Gr UP IV : d" " d C-8 and 2 h o u r r u t e r d ^ d ^ t " * ^ - " 1^ ^ not contain T S C ft CB1 Company SanM 0" All rats were weighed and observed over a 14-day recovery period and thensacr i f i c ^ . A range-finding study to find the tolerated dose level of conducted prior to the start of the test. The surviving rats were weighed and observed during a 14-day recovery period and then sacrificed.*** Results : Dose (mg/kg) 500 500 Compound C-8 C-8 500 C-8 500 C-8 j^MHH^H^^HMirreatment None ^ Immediate post-dose 2-hour pre-dose 2-hour post-dose Dose Mortality 0 mg/kg 5/6 1000 mg/kg 0/6 1000 mg/kg 1000 mg/kg 1/6 0/6 Purity: Contaminants : Synomyns:_o Ammonium perfluorooctanoate CAS Registry No.: ** Composition : Synonyms : CAS Registry No.: *** In a Range Finding Study, rats dosed from 200-1000 mg/kg, 1 rat per dose level and 6 rats dosed at 1,000 mg/kg, showed no clinical signs of toxicity. - 2- - ^ tscacs ..j :/^ 'L Jf.Report by: Lon Hinckle Technician Reviewed by: 0. Louis Dashiell Study Director Approved by: LH :jrg :WP: 3.8 Date Issued: Deceml Report No. 828-81 31, 1981 ,flJ -3*. iC.--- V, Gerald L. Kennedy, jjr. Section Supervisor Acute Investigations -3- n0t con'1TSCA S awllzed.00^