Document G61M6O30yEB2XkkQDN785obwY

Oc t o b e r 5 , 19 I4- Mr* Hugh P o a s e t t Ih A s s o c i a t e d E t h y l The Ad e lp h i Lo n d o n , W, C. 2 En gla n d Co m p a n y Ltd . De ar Mr, P o a s e t t ; Yo u r l e t t e r o f Au g u s t 2 1 3 t ra is e s a s e rie s o f que stio n s Miich i t is ve ry d i ffic u lt t o a n s w e r . We h a v e c o n s i d e r e d d i f f i c u l t i e s o f t h i s k i n d under e m erge ncie s and have tr ie d to fin d what co u ld be done tow ard the d is p o s itio n o f F lu id . I fe e l th a t in ge n e ra l your approach to the problem has been q u ite s a t is fa c t o r y , and I th in k you are q u ite r ig h t in be l i e v i n g th a t under the co n d itio n s o f f i r e , the Eth y l Flu id w ould be Ig n it e d and in la rg e p a rt co m p le te ly dispose d o f. The g r e a t e s t d a n ge r fo r th e men i s t h a t o f e xp o s u re to v a p o r s , and I b e li e v e you w ill r e a liz e th at o n ly b r ie f exposures to co n - . ce n tra te d vapo rs w i ll produce acu te i l l n e s s and pe rhaps f a t a l i l l n e s s . The p r o t e c t i o n w h ic h y o u h a v e s u g g e s t e d a ga in s t sk in co n tact sho uld be ade quate , but a gre a t d e a l o f care w i l l be re q u ire d to se e th a t any such equipm ent i s ke pt in t a c t and in good c o n d itio n . Oth e r w ise any le a k or bre ak in th e m a te ria l w i l l be d is a s t r o u s . The m o at d e t a i l e d c a r e s h o u l d be t a k e n i n t h e s e m a t t e r s i f and when i t i s p o s s i b le ,, and th e men th e m s e lv e s s h o u ld know how to p r o t e c t th e m s e lv e s . In t h i s c o n n e c tio n i t s h o u ld be remembered t h a t w ashin g t e t r a e t h y l o f f 1the s k in w ith ke ro se ne i s ve ry e ffe c t iv e i f i t i s done p ro m p tly, b u t i t sho uld be done w ith in fi ft e e n m inute s o f the tim e o f s k in c o n t a c t o r i t i s l i k e l y to be in a d e q u a te . As to th e vap o rs , v a rio u s th in g s s u gge s t th e m s e lve s , fo r e xam ple , the use o f m asks, p re fe ra b ly a ir lin e m asks, or the use o f masks c o n t a i n i n g c h a r c o a l i f n e c e s s a r y . The c a n i s t e r s o n c h a r c o a l masks w i l l have to be changed fre q u e n tly and no tro u b le or e xpense sho uld be spare d in d o in g t h i s . So f a r a s p r o p h y la x i s i s co n ce rn e d , I th in k i t w i l l be fo un d t h a t any ty p e o f p r o p h y la x is w i l l be l a r g e l y u s e le s s u n le s s in d e e d th e re may be some b e n e f i c i a l p s y c h i c e f f e c t . The m e th o d o f KF 0015797 2 tre atm e n t w hich I s u gge s te d in 1925 and w hich has be e n c ite d by Dr, Ro be rtso n , is pro bably v a lu e le s s , or a t l e a s t i t i s c e r t a i n t h a t i t do e s n o t work in. the way I o r i g i n a l l y t h o u g h t t h a t i t w o u ld . The l e a d co m po unds absorbe d are re le a s e d fa i r l y prom ptly and are e xcre te d i n c o n s i d e r a b l e a m o u n t. The e x c r e t i o n i s n o t b e n e f i c i a l l y i n f l u e n c e d b;/ th e a d m i n i s t r a t i o n o f s a l t s w h ic h I a d v i s e d , and the c h ie f b e n e fit o f such s a lt s i s th at the y te nd to have a m ild ly c a t h a r t ic e ffe c t and to m a in ta in the s a l t b a la n c e o f th e b o d y . I t may be b e n e fi c i a l and i t i s n o t l i k e l y to be ve ry u s e fu l. In g e n e ra l, ho w e ve r, the p ro gra m o u t l i n e d i s a d v a n t a g e o u s . So f a r as men who have h ad s e r io u s e xp o s u re i s co n ce rn e d , th e y m ust be k e p t under m e d ical s u p e rv is io n a t a l l c o s t s . In a d d itio n I s u g ge s t th a t Dr. Ro be rtso n examine the a r t i c le p u b lis h e d b y D r . Machl e on t e t r a e t h y l l e a d s i n c e he w i l l f i n d t h e r e a . r a t h e r .co m p le te : d e s c r i p t i o n o f th e m e th o d s o f t r e a t m e n t w h ich we a re u s i n g a t t h e p r e s e n t t i m e , an d w it h f a i r l y good r e s u lt s . I vfish t h a t I co u ld be o f a g r e a t d e a l more a s s i s t a n c e th an t h l g l e t t e r In d i c a t e s . I am a f r a i d , h o w e v e r , t h a t we w i l l h a v e t o r e c o g n i z e th e g e n e r a l p r i n c i p l e s o f safety m e as u re s and a p p ly the m i n a c c o r d a n c e w i t h o u r b `>s t ju d gm e n t In an y s i t u a t i o n w h ich may a r i s e . Sin ce re ly yo urs, RAKs i s R o b e r t A. Ke h o e , M.D . P .S . A "s a fe t y m an u al" r e c e n t l y co m p le te d w i l l be a v a i l a b l e s h o r t ly and a co p y w i l l be s e n t to y o u . A s e c t io n on mergendie may be u s e f u l i n t h i s c o n n e c t i o n . RAK. Ke 0 0 1 5 7 9 8