Document G5x5EXeEoYxxZpww2KK6eMr37

AR226-1389 rn !r=> E. i. P.; \ ' d e N e v .o l t -.s E C o m p a d / W i l m i n g t o n . D e l a w a r e 1933S PO LYM C f? P R O O U C T S OCF /FsTMCNY >. PtlKI v.t.NT * L S T A T I O N PERSONAL AND CONFIDENTIAL M <8&<S \M c c : A . J . P.) : 1 B. w. 71_.:r :j L. J . ? "i ; r. Pr a 1 P ile -j --',1.d p ) - D'm July 16, 1981 TO: DR. Y . L. POKER - PPD, Parkersburg FROM: S. S. STAFFORD ANALYSIS OF BLOOD SAMPLES FOR FERFLUOROOCTANOATE (Job No. 810-578; PRAL Nos. 81-2218-2232,81-2600-2604,81-2758; _________________ Notebook Nos. E22514,E26238)__________________ As requested in your letters of 5/18 and 6/12/G1 to L. J. Papa, che 21 blood samples submitted then have been analyzed for perfluorooctanoate (Cg). Results and sample identification are given in the attached table. As noted there, the analyses were done using a gas chromatographic method specific for Cg (Lab Method Number ES-567) but results have been reported as ppm F. for comparison with total organic fluorine analyses. Precision is + 10% relative standard deviation over most of the concentration range, somewhat less at the lowest values. The lower limit for quantitation is 0.007 ppm F (0.01 pptn perfluorooctanoic acid), with a detection limit of 'v 0.004 ppm which can be distinguished from the reagent background but not well quantitated. Please contact me (772-4440) or "L. J. Papa (772-2745) if you have any questions regarding the analyses. General questions on blood sampling can be directed to J. W. Raines or L. F. Percival. Attachment jah Key Words: Perfluorooctanoic Acid Perfluorooctanoate Blood Analysis GC 000169 EID713276 TABLE I CONCENTRATION OF PERFLUOROOCTAKOATE IN BLOOD (a) Sattnle PRAL No. Date Sampled 31-2218 81-2219 31-22*0 81-2221 81-2222 81-2223 81-2224 81-2225 81-2226 81-2227 81-2228 81-2229 81-2230 4/29/81 4/29/81 4/30/81 4/30/81 5/1/31 5/1/81 5/1/81 5/4/81 5/7/81 5/8/81 5/11/81 5/14/81 5/14/81 PF..R.No. Name REDACTED C\V <\ 81-2231 81-2232 81-2600 81-2601 81-2602 81-2603 81-2604 81-2758 5/14/81 4/30/81 5/19/81 5/19/81 5/26/81 5/28/81 6/1/81 6/19/81 REDACTED GC Analysis Dace Analyzed [Cg], ug F/g bln. 6/12/81 6/12/81 6/12/81 6/12/81 6/12/81 6/12/81 6/11/81 6/11/81 6/11/81 6/11/81 6/8/81 6/8/81 6/8/81 t 6/9/81 & 6/8/81 6/8/81 6/17/81 6/17/81 6/15/81 0.034 0.009 0.76 0.093 0.64 0.031 0.17 3.9 4.8 0.045 0.042 0.095 0.25 0.31 1.3 2.1 0.019 0.012 6/17/81 6/17/81 6/26/81 0.057 0.75 0.095 (a) Analysis is described Acid in Blood, Gas Ch packed column GC anal (b) Although the analysis concentrations are given In ppm fluorine for comparison with the results of total organic fluorine analyses. (ppm F 0.688 x ppm perfluorooctanoic acid) Estimated uncertainty is + lOt relative standard deviation. The lower limit for quantitation is 0.007 pgF/g. The detection limit is 0.004 ugF/g, but concentrations in that range cannot be well quantitated and are reported as < 0.007. None detected (n.d.) is reported for samples with [Cg] < 0.004 ppm, which cannot be distinguished from reagent background. 000170 EID713277