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To: 'Bruce Jarnot' <jarnotb@api.org> From: Cagen, Stuart Z SHLOIL-SHOIL-SHS </O=SHE LUOU=MSXSCC/CN=RE CI PI ENTS/CN=SC724012> Cc: Bcc: Received Date: 2007-06-0720:07:28 GMT Subject: RE: BPSC... *Correction* Conf Call toll-free phone: 1-866-443-0059 (not 1-800) Notes from today's Regulatory Support Team call: A) Current advocacy: TCEQ ESL support B) Potential ideas for consideration, depending on value and feasibility 1) Fine tune potency estimates based on Pliofilm cohort. Consideration of better exposure estimates and alternative dose response models. E.g, a) Chemrisk (including dry side exposure estimates) b) Summit 2) Biomonitoring - No action right now considering ILSI consideration of Dow Chemical perspectives on background levels of metabolites. 3) early cell effects as per report by Lan, et al regarding an association reported between benzene exposure and effects on progenitor cells. Perhaps this is in need of an expert opinion 4) Consideration of options concerning report by Lan, et al of blood count effects at benzene levels of 1 ppm. Options might include further evaluation of the basis of the conclusion, such as review of the exposure assessment. 5) VCCEP publication 6) VCCEP recommendations by the EPA and subsequent industry response 7) longer term data analysis and implications of work anticipated in the next few years; Shanghai and the metaanalysis 8) expert opinion of functional threshold for benzene effects C) Need for timetable of ideas mentioned above (idea, options, when possible) Short term, long term .... Analysis, advocacy, research Stuart Cagen, Ph.D. Senior Toxicologist Shell Health Services One Shell Plaza 910 Louisiana Street Houston, Texas 77002 Telephone: 1-713-241-1407 Fax: 1-713-241-1596 Mobile: 1-832-646-3987 email: stuart.cagen@shell.com -----Original Message----From: Bruce Jarnot [mailto:jarnotb@api.org] Sent: Thursday, June 07, 2007 8:41 AM To: bberger@spriggs.com; benztf@listserve.api.org; carol.a.fairbrother@exxonmobil.com; carol.komin@fhr.com; ClaudeWhite@Lyondell.com; dghunt@dow.com; JSBus@dow.com; karen.jones@total.com; lawrence.k.low@exxonmobil.com; marcy.banton@lyondell.com; Mark.Swanson@fhr.com; Clegg, Patsy M SCC-DCS/22; rjbreglia@sunocoinc.com; rossmacdonald@houston.rr.com; sapersm1 @bp.com; JIASZ@cpchem.com; Cagen, Stuart Z SHLOIL-SHOILSHS; ToxWorks@aol.com Cc: Russell White; Bruce Jarnot Subject: BPSC... *Correction* Conf Call toll-free phone: 1-866-443-0059 (not 1-800) SH ELL-MCCLU RG-065007 Importance: High Mea Culpa... the correct toll-free phone number is 1-866-443-0059 (not 1-800) for BPSC conference calls. Sorry for the confusion! Benzene Product Stewardship Committee (BPSC) - Here is the BPSC Subteam conference call schedule, as developed last week. To avoid confusion, we plan to use Bruce's PIN Code for all BPSC and Subteam conference calls ... CONFERENCE BRIDGE Phone No: 1-866-443-0059 (U.S. toll free) 1-770-765-9147 (International) PIN Code: 202-682-8473-# Noise control: *6 to mute / #6 to un-mute your line 1. REGULATORY SUPPORT Subteam Issue Leads: Stuart Cagen, Michael Bird, Bruce Jarnot Example: Texas TCEQ / Bz ESL Next Call: Thursday June 07, 2:00PM EDT /1 :OOPM COT /11 :OOAM PDT 2. ADVOCACY / RESEARCH RESPONSE Subteam Issue Leads: Jim Bus, Stuart Cagen, Rob Schnatter, Michael Bird, Bruce Jarnot Example: Lan et ai., Kim et al. publications Next Call: Monday June 18, 10:00AM EDT / 9:00AM COT / 7:00AM PDT 3. COMMUNICATION PLAN Subteam Issue Leads: David Hunt, Craig Parker, Tracy Hammon, Russ White Example: Website content SH ELL-MCCLU RG-065008 Next Call: Tuesday June 12 at 1:30PM EDT I 12:30PM COT 11 0:30AM PDT 4. EXPOSURE DETERMINATION Subteam Issue Leads: Sophie Jia, Patsy Clegg, Russ White Example: Walker I Houston Ship Channel exposure critique Next Call: Thursday June 07 at 9:00AM EDT I 8:00AM COT I 6:00AM PDT 5. GLOBAL HARMONIZED SYSTEM Subteam Issue Leads: Patsy Clegg, Bruce Jarnot Example: GHS analysis, looking at Japan or Track implementation by country Next Call: N/A Best Regards - Bruce. Attachments: Cagen, Stuart Z SHLOIL-SHOIL-SHS.vcf image001.gif SH ELL-MCCLU RG-065009