Document G5KBaJq57QpDL2YE7LdnOJZkY

Ja n u a ry 6* 1938 Mr, K, B. Bagchi O ffice o f Chemical Examiner to the Government, Bengal M edical C ollege . C alcutta, India Bear Mr. B ag ch ij- P le a s e a c c e p t my th a n k s f o r your two i n t e r e s t i n g a r t i c l e s on le a d in th u r in e and f e c e s , and on a r s e n i c in human t i s s u e s and e x c r e t a . These d a ta a re v e ry I n t e r e s t i n g to me and I hope you w i l l send me any f u r t h e r a r t i c l e s w hich come o u t on the continuation of these s tu d ie s. ' I t o c c u rs t o me t h a t you w i l l be i n t e r e s t e d in some o f th e work which we have been d o in g and t h a t you may f i n d p a r t i c u l a r l y u s e f u l th e d a ta w hich we have o b ta in e d on th e stu d y o f la r g e u m b e rs o f u r in a r y sam ples b o th on s in g l e in d iv id u a ls and' on la r g e numbers o f s u b je c ts ta k e n a t random. There seems no doubt th a t the le ad in ta k e and o u tp u t o f the people stu d ied by you is low er than th a t of persons in the American p o p u la tio n . On th e o th e r hand I may sa y in a l l f ra n k n e s s t h a t I am ju s t a l i t t l e sk e p tic a l as to the degree of v a ria b ility of r e s u l t s o b ta in e d on th e u r in e sam p les. In our e x p e rie n c e the la rg e s t s in g le fa c to r which produces gro ss v a ria tio n in the u rin ary lead ex cretio n of a sin g le in d iv id u al is the w ater o u tp u t from day to day* ( I r e f e r h e re , of c o u rs e , to sta n d a rd c o n d itio n s of le a d ex p o su re . Thus i f th e le a d I n ta k e i s s u b s t a n t i a l l y th e same from day to day, lead output in the u rin e w ill vary c h ie fly w ith the w ater o u tp u t.) In o th e r words the amount of w ater con sumed i s a f a c t o r and the amount l o s t in p e r s p ir a tio n is a ls o an im p o rta n t f a c t o r . The d if f e r e n c e s due to th is f a c t o r w i l l be se e n c l e a r l y i n s tu d ie s made on s u b je c ts under la b o ra to ry c o n d itio n s , as d e sc rib e d in one o f the a r t i c l e s whbh I am se n d in g you. T his b r in g s me to sa y t h a t b ecau se of y o u r i n t e r e s t in t h i s s u b j e c t , I am s e n d in g you, u n d er se p a ra te co v e r, a number of r e p r in ts which d escrib e th e , r e s u l t s o f some o f o u r s tu d ie s in t h i s la b o r a t o r y , B nfortu n afeely some of them were p u b lis h e d in jo u r n a ls K 0019869 II, Bagchi 2 th a t do n o t have any aide in te rn a tio n a l dissem ination and they a r e * th e re fo r e , n o t e a s ily a v a ila b le to workers o u tsid e of th U nited S tates* In atiy case I hope you. w ill f in d th e s e o f some i n t e r e s t and seme v a lu e , and I b e lie v e t h a t th e .tw o m ost r e c e n t a r t i c l e s on m ethods of a n a ly s is w i l l be of some p r a c t i c a l u se to you* Sincerely yours, E Alijis H o b ert A#" Ke'hoe, l i . I) KF 0019870