Document G5DY92q69wrNG8pXjq0x4G6Gx

UQXC//J Interoffice Communication To ' W. V. Henry , VCM PB 8491, Lake Charles received SEP 91980 From W. D. Broddlie, Environmental Conser., Ponca City Data Subject September 5 1980 TOXIC LIMIT S IN HUMANS EXPOSED TO BENZENE 1^= 0 <n The following infornatlon concerning the above subject was obtained from a literature r eview of benzene toxicology: Exposure (Conc./t ime' 50-150ppm/Several h ourii SOOppm/Short interval l,500ppm/l hour 3,000ppm 7,500ppm/ 1/2 -It our 20,000ppm (65mg/l) to 25,OOOppm/5 to 10 n in. or 15ml oral dose Effects in Humans Headache, weariness, decreased appetite, red blood cells, monocytes, and eosinophils Dizziness, drowsiness, headache, and nausea Severe toxic effects Only tolerated for 1/2 to 1 hour Dangerous to life May be fatal Reference (see attachment) ,1 2 1 ! 3, 7 1 4, 5, 6, 7, and 8 I hope the above it fomation is useful, and please call if any questions arise. W. D. Broddle, Ph. D. Senior Toxicologist Environmental Conservation mt cc: -Tom Grumbles, Houston We 000012926 REFERENCES 1. American Petroleum Institute Toxicological Review of Benzene, 2nd edition, 1960. 2. Hygienic Guide Seri es. American Industrial Hygiene Association, vol. 1, 1978. 3. Criteria for a Reconmetided Standard: Occupational Exposure to Benzene, U.S.D.H.E.W./ NIOSH, p. 24, 1974. 4. Toxicology of Drugs anc Chemicals, W. 2. Deichmann and H. W. Gerarde, ?. 642, 1969. 5. Industrial Hygiene and Toxicology, 2nd revised edition, vol. II, F. A. Patty, Pg. 1221, 1963. 3. American Industrial Hygiene Association Journal, vol. 41, No. 9, p. fii6 1980. 7. Chemical Hazards of the| Workplace, N. H. Proctor and J. P. Hughes, pp. 118 - 119, 1978. 3. Registry of Toxic Ecfects of Chemical Substances, vol. II, 1977. yvc ooooiz927