Document G5D1JK0awqxn6a77yGankKVnx

St 3M KSaalttvhiee PEsRieosn, PhD. na ESafnetyrSeorvnesTeiony - BuiBns6A3m5e% [1 HELb SSstentsass bY AR226 - 11S CERTIFIED MAIL 8EHQ - 1202 _ 00373 December 4, 2002 Document Processing Center (7407M) EOfPfAiceEoasftP--olRloutoimon6P4r2e8veAntttino:nSaencdtiToonx8i(cs) U1S200EPPeAnnsylvania Ave, NW. `Washington, DC 20460-0001 epiTZH poyAnnaRY ~B 58 2 TsuSlfCoAnat8e(E()PSFOUSB)S,TpeArNflTuIoAroLheRxIanSeKsuSlUfoPnPatLeE(MPFEHNST),ANL-mNeOthTyIlC-NE-aOcNe:tylP-erfluorooctane ~~ =2 . perfluorooctancsulfonamide (M570) 2 Reference SEHQ -1180-373, 374 Dear Sir: 3M has received the draft report for a repeated dermal contact absorption/toricology Study in rats conducted with four mill-applied and aftermarket carpetfabric/upholsiery protector products that 3M ceased manufacturing 2s part ofits perfluorooctany] cprhoedmuicsttsr.iesThpheasree-soulutts. inTdhiecaatetttahcathmreenpteahteerdetdoaiplryodviedremsalthceonctoamcptosoivteiroan2f8o-rdcaaychpoerfitohdese with these formulations, in the liquid state or afier application and drying on gauze, preesruflltueodroioncitnacnrcesauslefsonaabtoeve(PbFaOcSk)grionulnidvecroanntrdolsseriunmth(ealclobnuctenotnreatpiroondoucf), and of perfluorohexanesulfonate (PFHS) and N-methyl-N-acetyl-perfluoraoctanesulfonarmide (`mMe5t7ab0o)liitne soefraumma(nnuoftamcetaursiunrgedreisnidiuvaelr)(Nf-omrectehrytla-ipneprrfolduucotrso.octMaSn7es0ulisfoannaimnitdeoremtehdainaorly (N-MeFOSE)) present in certain products, which can be further metabolized to PFOS No toxicity atributable to any sample was evident in this study, cither on the skin, or systemically. "The study was conducted by the Fraunhofer Institute of Toxicology, Hanover, Germany. bCeoettnoanppglaiuezdeapnadtcahlelso(w~e1d tsoqudarrye, oinrclhi)qutiodwshaimcphlethse(0l.i1qumidi)teasptpmlaiteedritaolghaaudzeprweivtihoouustly drying, were applied to the shaved dorsal skin of male and female rats in a semi-occluded cfoatsthoinongafourzesixinhvooulrvsedeascahtudraatyinfgorthuepgtaou2z8e dwaiytsh.lTihqueidprperpoadruactti,onworfitnhgiengsatmhpelseastudrraiteeddon gauze through a roller press at 100 pounds pressure and allowing the wrung gauze to air dry at room temperature. As such, the applicationofproduct to gauze did not precisely GLEH - Zo-3 2 ; 000 2 (15a SANE G i. PaOfgfeiceNoofr2P:ollu`rtiigosnP<r0evetnuttionvaerodFoxEiAosR- iEL Deceombner 4,tin2002 wowed tmhiemhiicghneorremnadl aopfpnloircaftailonproondcuacrtpeatp,plfiacbartiicosn.anTdhuephloilqsutidersyabmiptl'ewsawseerxepeacdtjeudstteodrteopresent parpoplviieddetaoppfrreosxhimgaatuezleynt'ahe vsoalmuemaemoofun0.t1.ofFprreosdhuctrtesaotleiddspaatschpersesweenrteinaptphleiderdieeadcshamdapyl.es dPaeitresrmoifnraattiso,n2o/sfcxP,FwOeSrelesvaeclriifnicleidveoranuddayPsFO4S,,14,PF2H8Sa,ndan4d2MfoSr 0patlheovellosgyina'nsderum (selected time points). Rats sacrificed on day 42 were treated for the first 28 days followed by a 14-day period without treatment. sReapmepalteesdrdeesrumlatleicdonctoancstisutnednetlrysqeumain-toicfcilaublseivseecrounmdiatnidonlsivweirtchonacllenbturtatoinoenosf,tofhePFteOstS that . `eexxcceepetdieodn lweaveslsamiinlglo-natprpollicrda.tscaerxppeotsperdotteoctgora.uzeWpiatthchtehastmporiosdtuectn,edonolnyl.yonweitmhalsaeligngx..poTshede to the liquid proditct for 28 days, and one female exposed to previously treatedanddried (`gLaOuzQe)opaftc1h0esppfbo.r2A8ldlaoytshesrhsoawmepdlelsivwererPeFbOeSfolwevtelhse aLtOcQl.oseMt5o7t0hewlaesveldeotfecqtueadntaittation cSoanmspilsetse.ntlTyhiqsuasnaimipfilaeblaelsloevyeilesldinedsetrraucme flervoemlse(xapboosuutre1 tpgpbo)ployfoPnFeHoSf tihnesperroudmuocftras ienxptohesesdedrauimloyffgorni2m8adlasyse.xpPosFeHdS10wtahse aplrsoodduecttetchtaetd aaltshoiygiheelrdeldevtehles h(iugphteostabliovuetr 1(uppptmo)7- 10 ppm) and serim (up to 1 ppm) levelsof PFOS. . . 3M will submit the final report to EPA when available., Becauseofdifferences in the `nature of the treated fabric (cotton gaze v. carpet or upholstery) and conditions of dtoerPmFaOlSc,onPtFacHtS, tahnedseNd-aMtaccFaOnSnEotfbreomusceodntqaucatntwiittahtitvreelaytetdo mdaettereiramlisn.e hThuemsaendeaxtapodsou,res whiotwhevtehre,seinmdaitceartiealtshaitspdoesrsimballe.absAosrpitnidoincaotfedPFabOoSv,e,P3FHMSdiasncdoNnt-iMnueeFdOtSheEmfarnuofmaccotnutraectof these products for commercial sale as part of 3M's phase out of its perfluorooctanyl chemistries. Please contact Dr. John L. Butenhoff(651-733-1962)ifyou have any questions orifwe can provide additional information. Sincerely, Katherine Staff Vice E. Reed President, Environmental Technology and Safety Services Enclosure A